BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 2/28/2026
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 6.03% | 5.70% | 60.37% | 10.56% | 62.26% | 19.25% | -0.31% | 8.72% | 16.98% | 04/07/2010 |
| BIB Market Price | 6.05% | 5.51% | 60.28% | 10.49% | 62.05% | 19.26% | -0.28% | 8.72% | 16.98% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Net Assets $78,549,135
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 3/19/2026- NAV $77.77
- NAV Change $+0.72
- Market Price $77.75
- Market Price Change $+0.73
- Trading Volume (M) 9,500
- 30-Day Median Bid Ask Spread 0.24%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Net Assets $78,549,135
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 3/19/2026- NAV $77.77
- NAV Change $+0.72
- Market Price $77.75
- Market Price Change $+0.73
- Trading Volume (M) 9,500
- 30-Day Median Bid Ask Spread 0.24%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 12/31/2025
Holdings
as of 3/19/2026
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 6.87% | GILD | GILEAD SCIENCES INC | -- | $5,396,751.95 | 38,245 | 2369174 |
| 6.47% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,083,438.90 | 11,098 | 2931034 |
| 6.21% | AMGN | AMGEN INC | -- | $4,875,435.36 | 13,933 | 2023607 |
| 4.29% | REGN | REGENERON PHARMACEUTICALS | -- | $3,370,883.95 | 4,571 | 2730190 |
| 2.32% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $1,818,690.60 | 5,846 | B00FWN1 |
| 1.73% | INSM | INSMED INC | -- | $1,358,928.00 | 9,437 | 2614487 |
| 1.52% | BIIB | BIOGEN INC | -- | $1,190,697.72 | 6,492 | 2455965 |
| 1.28% | UTHR | UNITED THERAPEUTICS CORP | -- | $1,003,408.00 | 1,904 | 2430412 |
| 1.15% | MRNA | MODERNA INC | -- | $905,424.93 | 17,289 | BGSXTS3 |
| 1.12% | ARGX | ARGENX SE - ADR | -- | $880,951.50 | 1,287 | BDVLM39 |
| 1.10% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $860,972.30 | 18,910 | BMVP7Y0 |
| 1.09% | ILMN | ILLUMINA INC | -- | $855,874.99 | 6,761 | 2613990 |
| 1.09% | ROIV | ROIVANT SCIENCES LTD | -- | $855,656.20 | 30,779 | BMW4NZ9 |
| 1.08% | RVMD | REVOLUTION MEDICINES INC | -- | $849,425.95 | 8,555 | BL71K91 |
| 1.03% | INCY | INCYTE CORP | -- | $807,456.65 | 8,687 | 2471950 |
| 0.88% | VTRS | VIATRIS INC | -- | $688,122.00 | 50,972 | BMWS3X9 |
| 0.77% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $608,342.76 | 2,718 | BV9G6B8 |
| 0.76% | BBIO | BRIDGEBIO PHARMA INC | -- | $597,556.96 | 8,528 | BK1KWG8 |
| 0.73% | MEDP | MEDPACE HOLDINGS INC | -- | $574,767.24 | 1,247 | BDCBC61 |
| 0.73% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $572,236.40 | 4,412 | 2623911 |
| 0.68% | SNY | SANOFI-ADR | -- | $531,022.08 | 11,712 | 2964557 |
| 0.66% | SMMT | SUMMIT THERAPEUTICS INC | -- | $517,926.84 | 32,947 | BMTVQS7 |
| 0.65% | IONS | IONIS PHARMACEUTICALS INC | -- | $511,150.44 | 7,167 | BDJ0LS6 |
| 0.65% | GH | GUARDANT HEALTH INC | -- | $509,983.00 | 5,725 | BFXC911 |
| 0.62% | EXEL | EXELIXIS INC | -- | $489,549.90 | 11,865 | 2576941 |
| 0.62% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $488,860.20 | 2,689 | B4Q5ZN4 |
| 0.60% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $467,865.06 | 8,502 | 2437071 |
| 0.58% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $455,582.66 | 1,003 | BD59BS7 |
| 0.51% | BNTX | BIONTECH SE-ADR | -- | $399,572.94 | 4,474 | BK6H543 |
| 0.50% | ONC | BEONE MEDICINES LTD-ADR | -- | $394,111.68 | 1,394 | BYYWPW6 |
| 0.49% | IBRX | IMMUNITYBIO INC | -- | $384,472.62 | 43,591 | BNSP0B8 |
| 0.47% | TEM | TEMPUS AI INC-CL A | -- | $372,812.26 | 7,649 | BSLSJJ0 |
| 0.45% | AXSM | AXSOME THERAPEUTICS INC | -- | $354,461.28 | 2,231 | BYZR4X4 |
| 0.44% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $342,329.60 | 6,010 | BYQBFJ8 |
| 0.43% | CYTK | CYTOKINETICS INC | -- | $340,685.40 | 5,412 | BBBSBJ5 |
| 0.42% | KRYS | KRYSTAL BIOTECH INC | -- | $330,756.00 | 1,282 | BD6JX35 |
| 0.42% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $329,332.50 | 1,107 | BQ721R4 |
| 0.42% | HALO | HALOZYME THERAPEUTICS INC | -- | $329,320.35 | 5,205 | 2975098 |
| 0.41% | ABVX | ABIVAX SA-ADR | -- | $321,341.30 | 2,612 | BLC89B2 |
| 0.40% | PCVX | VAXCYTE INC | -- | $312,652.16 | 5,792 | BKPVGH6 |
| 0.40% | NUVL | NUVALENT INC-A | -- | $310,300.82 | 3,197 | BMVBZD3 |
| 0.37% | ACLX | ARCELLX INC | -- | $292,570.47 | 2,559 | BPCJ1Q2 |
| 0.36% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $281,348.56 | 2,767 | BDCBCD8 |
| 0.34% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $266,685.43 | 2,953 | BF2YWG4 |
| 0.32% | KYMR | KYMERA THERAPEUTICS INC | -- | $253,350.88 | 3,184 | BMPRZV5 |
| 0.30% | PTCT | PTC THERAPEUTICS INC | -- | $238,384.55 | 3,554 | B17VCN9 |
| 0.30% | COGT | COGENT BIOSCIENCES INC | -- | $235,140.34 | 6,794 | BLR6XK8 |
| 0.30% | CGON | CG ONCOLOGY INC | -- | $235,054.34 | 3,569 | BRBCSP4 |
| 0.30% | CAI | CARIS LIFE SCIENCES INC | -- | $234,861.66 | 12,486 | BT18HP9 |
| 0.26% | ALKS | ALKERMES PLC | -- | $207,490.40 | 7,306 | B3P6D26 |
| 0.26% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $206,297.28 | 2,274 | BJDX8Y8 |
| 0.26% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $205,432.50 | 4,515 | BFZQ0L8 |
| 0.25% | CRSP | CRISPR THERAPEUTICS AG | -- | $197,988.15 | 4,217 | BDHF4K6 |
| 0.25% | FOLD | AMICUS THERAPEUTICS INC | -- | $196,373.28 | 13,656 | B19FQ48 |
| 0.25% | TERN | TERNS PHARMACEUTICALS INC | -- | $195,553.16 | 3,986 | BMDJ0C9 |
| 0.24% | ERAS | ERASCA INC | -- | $191,589.30 | 12,555 | BNLYBF3 |
| 0.24% | XENE | XENON PHARMACEUTICALS INC | -- | $188,736.57 | 3,421 | BRJ3GY4 |
| 0.23% | IMVT | IMMUNOVANT INC | -- | $183,476.70 | 7,758 | BJRFSB7 |
| 0.23% | LGND | LIGAND PHARMACEUTICALS | -- | $183,126.30 | 870 | 2501578 |
| 0.22% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $171,686.42 | 13,913 | BFNF1D6 |
| 0.21% | INDV | INDIVIOR PHARMACEUTICALS INC | -- | $168,451.50 | 5,523 | BTZRLN8 |
| 0.21% | APGE | APOGEE THERAPEUTICS INC | -- | $166,249.50 | 2,427 | BM9HHL5 |
| 0.20% | ADMA | ADMA BIOLOGICS INC | -- | $158,220.68 | 10,534 | B9NSBM2 |
| 0.20% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $155,151.36 | 7,488 | 2713317 |
| 0.19% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $152,817.82 | 5,017 | BP8JSP4 |
| 0.19% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $150,408.18 | 4,199 | BDD19F8 |
| 0.19% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $149,210.22 | 2,957 | BQS9486 |
| 0.18% | SYRE | SPYRE THERAPEUTICS INC | -- | $145,250.23 | 3,433 | BQBBDY8 |
| 0.18% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $140,784.25 | 4,685 | BKY5JZ8 |
| 0.16% | DNLI | DENALI THERAPEUTICS INC | -- | $128,177.50 | 6,490 | BD2B4V0 |
| 0.16% | IDYA | IDEAYA BIOSCIENCES INC | -- | $126,488.00 | 3,880 | BK0VHF6 |
| 0.16% | TARS | TARSUS PHARMACEUTICALS INC | -- | $125,490.00 | 1,880 | BMH5RL1 |
| 0.16% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $124,218.02 | 5,422 | BKX9VD3 |
| 0.16% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $123,907.08 | 2,537 | B72ZBG4 |
| 0.15% | TWST | TWIST BIOSCIENCE CORP | -- | $121,228.80 | 2,706 | BGKG6G7 |
| 0.15% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $120,983.46 | 4,269 | BLB0YQ9 |
| 0.15% | VERA | VERA THERAPEUTICS INC | -- | $116,952.99 | 2,827 | BL55460 |
| 0.15% | TNGX | TANGO THERAPEUTICS INC | -- | $115,166.52 | 5,961 | BP2P6L0 |
| 0.15% | VCYT | VERACYTE INC | -- | $114,631.66 | 3,497 | BFTWZY0 |
| 0.14% | BEAM | BEAM THERAPEUTICS INC | -- | $113,013.30 | 4,490 | BK6L288 |
| 0.14% | DYN | DYNE THERAPEUTICS INC | -- | $112,531.60 | 6,322 | BN15WD1 |
| 0.14% | TVTX | TRAVERE THERAPEUTICS INC | -- | $109,771.20 | 3,960 | BLFGJD5 |
| 0.14% | ALMS | ALUMIS INC | -- | $109,210.14 | 4,303 | BPLQG36 |
| 0.13% | MAZE | MAZE THERAPEUTICS INC | -- | $105,236.47 | 2,129 | BSRK699 |
| 0.13% | APLS | APELLIS PHARMACEUTICALS INC | -- | $100,560.12 | 5,596 | BYTQ6X1 |
| 0.13% | IRON | DISC MEDICINE INC | -- | $98,932.24 | 1,672 | BMGJZJ8 |
| 0.12% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $97,174.77 | 4,543 | BLB0YH0 |
| 0.12% | TXG | 10X GENOMICS INC-CLASS A | -- | $94,730.52 | 5,154 | BKS3RS7 |
| 0.12% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $92,304.00 | 3,846 | BN7Q7R7 |
| 0.12% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $91,399.77 | 9,317 | 2100362 |
| 0.12% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $91,214.37 | 1,999 | BRXB0C0 |
| 0.12% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $91,192.50 | 6,755 | BJ5FZ74 |
| 0.11% | TYRA | TYRA BIOSCIENCES INC | -- | $90,181.16 | 2,362 | BMVNDH9 |
| 0.11% | WVE | WAVE LIFE SCIENCES LTD | -- | $89,712.24 | 7,402 | BYZG9R0 |
| 0.11% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $87,172.98 | 4,269 | BJ62Z18 |
| 0.11% | STOK | STOKE THERAPEUTICS INC | -- | $83,871.13 | 2,527 | BJQ05Z6 |
| 0.11% | GRAL | GRAIL INC | -- | $83,610.75 | 1,725 | BSLSSX7 |
| 0.11% | ORKA | ORUKA THERAPEUTICS INC | -- | $83,191.26 | 2,143 | BKVF0J2 |
| 0.10% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $82,112.52 | 5,836 | BFWLC09 |
| 0.10% | MLYS | MINERALYS THERAPEUTICS INC | -- | $81,503.28 | 3,501 | BP9N0G0 |
| 0.10% | DFTX | DEFINIUM THERAPEUTICS INC | -- | $81,338.94 | 4,359 | BV2DHY6 |
| 0.10% | ANAB | ANAPTYSBIO INC | -- | $79,217.28 | 1,224 | BDRW1L7 |
| 0.10% | ZYME | ZYMEWORKS INC | -- | $79,140.24 | 3,312 | BPCQZY9 |
| 0.10% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $78,941.35 | 2,627 | BMFD115 |
| 0.10% | OCUL | OCULAR THERAPEUTIX INC | -- | $77,977.83 | 9,429 | BNZB1X8 |
| 0.10% | SRPT | SAREPTA THERAPEUTICS INC | -- | $77,206.05 | 4,637 | B8DPDT7 |
| 0.10% | RLAY | RELAY THERAPEUTICS INC | -- | $76,700.00 | 7,670 | BN2R582 |
| 0.10% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $76,687.72 | 22,756 | BM9FJ13 |
| 0.09% | ANIP | ANI PHARMACEUTICALS INC | -- | $74,445.90 | 995 | BCDWBX6 |
| 0.09% | PHVS | PHARVARIS NV | -- | $74,078.55 | 2,835 | BMZ2X38 |
| 0.09% | VCEL | VERICEL CORP | -- | $73,304.86 | 2,239 | BSBMN89 |
| 0.09% | INVA | INNOVIVA INC | -- | $73,095.81 | 3,309 | BDDXF67 |
| 0.09% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $72,061.52 | 2,581 | BCBVTX1 |
| 0.09% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $70,887.69 | 2,549 | BKSGZN7 |
| 0.09% | SION | SIONNA THERAPEUTICS INC | -- | $70,057.26 | 1,974 | BQKXDX4 |
| 0.09% | NVAX | NOVAVAX INC | -- | $70,050.08 | 7,192 | BJDQXG4 |
| 0.09% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $68,297.05 | 4,861 | BPCK358 |
| 0.09% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $67,988.16 | 17,568 | BF0DMK7 |
| 0.09% | NTLA | INTELLIA THERAPEUTICS INC | -- | $67,406.90 | 5,126 | BYZM6C2 |
| 0.09% | NRIX | NURIX THERAPEUTICS INC | -- | $66,916.20 | 4,485 | BMVLGP2 |
| 0.08% | GMAB | GENMAB A/S -SP ADR | -- | $66,589.24 | 2,588 | BBC9WC7 |
| 0.08% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $66,583.62 | 3,726 | BMX9K07 |
| 0.08% | TRVI | TREVI THERAPEUTICS INC | -- | $60,722.50 | 5,675 | BJH9ZN0 |
| 0.08% | NVCR | NOVOCURE LTD | -- | $60,203.25 | 4,955 | BYSS4X4 |
| 0.08% | ARDX | ARDELYX INC | -- | $59,136.00 | 10,752 | BN89V40 |
| 0.07% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $58,007.24 | 1,931 | BLCD809 |
| 0.07% | RAPP | RAPPORT THERAPEUTICS INC | -- | $57,885.68 | 2,108 | BR3T9B6 |
| 0.07% | VIR | VIR BIOTECHNOLOGY INC | -- | $57,752.66 | 6,157 | BK4PZ38 |
| 0.07% | ATAI | ATAIBECKLEY INC | -- | $57,384.18 | 16,074 | BWJDYK1 |
| 0.07% | MBX | MBX BIOSCIENCES INC | -- | $56,461.98 | 1,986 | BQXJKH2 |
| 0.07% | HROW | HARROW INC | -- | $56,363.58 | 1,638 | BHNDW86 |
| 0.07% | ZBIO | ZENAS BIOPHARMA INC | -- | $55,527.12 | 2,376 | BQB42H3 |
| 0.07% | TSHA | TAYSHA GENE THERAPIES INC | -- | $55,280.88 | 12,123 | BNC1BX1 |
| 0.07% | KOD | KODIAK SCIENCES INC | -- | $53,217.42 | 2,348 | BFXC933 |
| 0.07% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $52,090.72 | 3,482 | BMZ4LN0 |
| 0.07% | PGEN | PRECIGEN INC | -- | $51,991.20 | 15,660 | BKM5C84 |
| 0.06% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $50,820.00 | 1,400 | BX7RSN3 |
| 0.06% | EYPT | EYEPOINT INC | -- | $50,512.77 | 3,663 | BMGS7L1 |
| 0.06% | ALVO | ALVOTECH SA | -- | $49,597.32 | 13,854 | BPNTJ34 |
| 0.06% | SEPN | SEPTERNA INC | -- | $48,074.40 | 1,980 | BQNKXX2 |
| 0.06% | ORIC | ORIC PHARMACEUTICALS INC | -- | $47,852.10 | 4,311 | BKVDFF7 |
| 0.06% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $47,508.66 | 907 | BL95N25 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $46,758.38 | 13,246 | BL53SR3 |
| 0.06% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $46,567.45 | 3,305 | BYP80F1 |
| 0.06% | SVRA | SAVARA INC | -- | $46,465.80 | 9,005 | BYXGN81 |
| 0.06% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $46,268.86 | 2,881 | BP7KZP7 |
| 0.06% | BCAX | BICARA THERAPEUTICS INC | -- | $45,565.75 | 2,425 | BQB42F1 |
| 0.06% | GERN | GERON CORP | -- | $43,785.95 | 28,249 | 2370381 |
| 0.05% | PCRX | PACIRA BIOSCIENCES INC | -- | $42,928.14 | 1,902 | B3X26D8 |
| 0.05% | QURE | UNIQURE NV | -- | $42,071.82 | 2,757 | BJFSR88 |
| 0.05% | GRFS | GRIFOLS SA-ADR | -- | $41,950.23 | 5,399 | B8K7T65 |
| 0.05% | INBX | INHIBRX BIOSCIENCES INC | -- | $41,841.15 | 645 | BNSP8K3 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $41,788.08 | 1,828 | BMGTLY5 |
| 0.05% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $40,979.52 | 7,344 | BLR7H87 |
| 0.05% | GHRS | GH RESEARCH PLC | -- | $40,638.64 | 2,744 | BP6C0S2 |
| 0.05% | FTRE | FORTREA HOLDINGS INC | -- | $40,031.31 | 4,089 | BRXYZ57 |
| 0.05% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $39,763.90 | 2,035 | BNFWZS4 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $38,518.48 | 2,072 | BZ7PJQ1 |
| 0.05% | XNCR | XENCOR INC | -- | $38,299.20 | 3,160 | BGCYWN8 |
| 0.05% | JANX | JANUX THERAPEUTICS INC | -- | $37,708.08 | 2,663 | BMFX8Y7 |
| 0.05% | SANA | SANA BIOTECHNOLOGY INC | -- | $37,374.30 | 11,790 | BMFJJ97 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $37,197.44 | 8,512 | BZ0QMB7 |
| 0.05% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $36,770.34 | 2,238 | BD06CS0 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $36,093.75 | 4,375 | BMCR7V2 |
| 0.05% | CTMX | CYTOMX THERAPEUTICS INC | -- | $35,845.22 | 7,499 | BYWVTY5 |
| 0.04% | ANNX | ANNEXON INC | -- | $35,157.96 | 6,404 | BMVV9R5 |
| 0.04% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $35,089.05 | 3,147 | BJLKVS6 |
| 0.04% | OMER | OMEROS CORP | -- | $34,905.68 | 3,139 | B4NB858 |
| 0.04% | MNKD | MANNKIND CORP | -- | $34,244.28 | 13,589 | BF081J4 |
| 0.04% | CGEM | CULLINAN THERAPEUTICS INC | -- | $34,191.12 | 2,614 | BM90J52 |
| 0.04% | BIOA | BIOAGE LABS INC | -- | $33,390.48 | 1,587 | BT9K6D8 |
| 0.04% | CSTL | CASTLE BIOSCIENCES INC | -- | $33,178.70 | 1,291 | BKLCWZ3 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $32,455.50 | 3,850 | BYZD465 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $32,251.13 | 1,733 | BD9GVY0 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $32,087.38 | 2,171 | BQS7491 |
| 0.04% | ARVN | ARVINAS INC | -- | $31,745.14 | 2,842 | BDZ30Q0 |
| 0.04% | TBPH | THERAVANCE BIOPHARMA INC | -- | $31,438.44 | 2,244 | BMNDK09 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $29,392.16 | 7,987 | BPBJFM7 |
| 0.04% | PSNL | PERSONALIS INC | -- | $28,256.70 | 3,930 | BJQ0608 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $27,505.40 | 10,579 | BBNBTD2 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $26,173.35 | 3,561 | BFYQFJ2 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $25,875.72 | 2,522 | BMFK3H6 |
| 0.03% | TECX | TECTONIC THERAPEUTIC INC | -- | $25,527.24 | 828 | BPBPCG8 |
| 0.03% | ETON | ETON PHARMACEUTICALS INC | -- | $24,674.76 | 1,188 | BGL0JK3 |
| 0.03% | SLDB | SOLID BIOSCIENCES INC | -- | $24,549.76 | 3,448 | BQHN6C7 |
| 0.03% | REPL | REPLIMUNE GROUP INC | -- | $23,922.08 | 3,472 | BDDVW37 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $23,899.83 | 4,171 | BMC3HS7 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $23,424.80 | 2,492 | BLFBZ32 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $23,256.00 | 7,200 | B3MZ6K5 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $22,692.46 | 2,527 | BKLXFX5 |
| 0.03% | VNDA | VANDA PHARMACEUTICALS INC | -- | $22,410.55 | 2,615 | B12W3P6 |
| 0.03% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $22,077.90 | 9,945 | BFZNYB7 |
| 0.03% | KMDA | KAMADA LTD | -- | $22,006.86 | 2,553 | B2Q9833 |
| 0.03% | CRMD | CORMEDIX INC | -- | $21,974.40 | 3,488 | BJ0LT31 |
| 0.03% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $21,919.94 | 5,399 | BYVQJ96 |
| 0.03% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $20,997.37 | 4,783 | BDFKQ07 |
| 0.03% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $20,932.20 | 802 | BQD3J33 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $20,851.73 | 641 | B292NQ7 |
| 0.03% | AVIR | ATEA PHARMACEUTICALS INC | -- | $20,742.00 | 3,457 | BLN9Z50 |
| 0.03% | ABSI | ABSCI CORP | -- | $20,500.48 | 6,656 | BN94K69 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $20,350.82 | 2,383 | B91XRN2 |
| 0.03% | TRDA | ENTRADA THERAPEUTICS INC | -- | $20,282.14 | 1,693 | BP81RK8 |
| 0.03% | UPB | UPSTREAM BIO INC | -- | $20,028.20 | 2,390 | BRCFFK6 |
| 0.02% | LYEL | LYELL IMMUNOPHARMA INC | -- | $19,461.49 | 937 | BTNMG41 |
| 0.02% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $19,443.51 | 6,417 | BMCWKZ2 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $19,002.58 | 7,394 | BN4JN37 |
| 0.02% | RGNX | REGENXBIO INC | -- | $18,734.76 | 2,241 | BZ0G875 |
| 0.02% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $18,706.80 | 13,362 | B4N8MH9 |
| 0.02% | LXEO | LEXEO THERAPEUTICS INC | -- | $18,695.91 | 3,229 | BQ6C357 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $18,483.22 | 2,809 | BP81R42 |
| 0.02% | ACRS | ACLARIS THERAPEUTICS INC | -- | $17,937.04 | 4,796 | BYV2W40 |
| 0.02% | IVVD | INVIVYD INC | -- | $17,784.25 | 12,265 | BM8NHS1 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $16,932.36 | 3,788 | BMXNGZ6 |
| 0.02% | FULC | FULCRUM THERAPEUTICS INC | -- | $16,853.76 | 2,394 | BJDX8Z9 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $16,614.00 | 1,278 | B9L5200 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $16,606.80 | 3,954 | BYTYP72 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $16,559.06 | 1,939 | BSMLR16 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $16,098.52 | 3,169 | 2107437 |
| 0.02% | LENZ | LENZ THERAPEUTICS INC | -- | $15,913.65 | 1,385 | BQV0J03 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $15,793.56 | 4,618 | BFY7DC4 |
| 0.02% | KROS | KEROS THERAPEUTICS INC | -- | $15,000.88 | 1,349 | BM7V485 |
| 0.02% | PEPG | PEPGEN INC | -- | $14,515.11 | 3,043 | BMTX3D7 |
| 0.02% | EOLS | EVOLUS INC | -- | $13,948.20 | 2,870 | BDRJH21 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $13,889.88 | 2,858 | BMVBZF5 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $13,714.50 | 2,230 | B7F2TY6 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $13,264.02 | 2,079 | BL5B6Z1 |
| 0.02% | NGNE | NEUROGENE INC | -- | $13,145.15 | 685 | BS2F741 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $13,109.80 | 4,444 | BZC0D70 |
| 0.02% | CABA | CABALETTA BIO INC | -- | $12,947.36 | 4,259 | BK5MWR1 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $12,695.54 | 8,878 | BFMLGR4 |
| 0.02% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $12,376.42 | 1,022 | BPRBTY7 |
| 0.02% | NBP | NOVABRIDGE BIOSCIENCES | -- | $12,374.00 | 4,600 | BKRRKY7 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $12,239.67 | 2,503 | BMF7DT9 |
| 0.02% | CADL | CANDEL THERAPEUTICS INC | -- | $11,931.30 | 2,430 | BP0TQC5 |
| 0.01% | OABI | OMNIAB INC | -- | $11,722.64 | 6,371 | BN13S71 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $11,595.36 | 2,499 | BPRB2N7 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $11,194.29 | 4,289 | BKX9NQ0 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $10,156.70 | 4,322 | BZ8FPH3 |
| 0.01% | VOR | VOR BIOPHARMA INC | -- | $9,811.65 | 745 | BRJJYT3 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $9,750.18 | 2,607 | BY7RB53 |
| 0.01% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $9,309.30 | 2,046 | BKDQKM6 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $8,613.50 | 5,350 | BRK0149 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $8,453.76 | 1,258 | BKC9SX3 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $8,147.92 | 4,136 | BNYJR68 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $7,454.55 | 8,655 | BNR5QT9 |
| 0.01% | HUMA | HUMACYTE INC | -- | $7,077.93 | 8,287 | BMYTJP4 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $6,751.65 | 2,369 | BP7L561 |
| 0.01% | LFCR | LIFECORE BIOMEDICAL INC | -- | $6,731.48 | 1,658 | 2517058 |
| 0.01% | CDXS | CODEXIS INC | -- | $6,674.99 | 3,997 | B5LL2C2 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $6,626.76 | 1,372 | BP2NYN2 |
| 0.01% | MENS | JYONG BIOTECH LTD | -- | $6,021.56 | 3,364 | BPTK6Z2 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $5,920.86 | 7,367 | BNNXX52 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $5,424.45 | 2,523 | BKTV702 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $4,965.70 | 4,318 | BNNXX18 |
| 0.01% | AARD | AARDVARK THERAPEUTICS INC | -- | $4,718.70 | 963 | BTXQTX3 |
| 0.01% | GOSS | GOSSAMER BIO INC | -- | $4,629.84 | 10,243 | BJ0CK86 |
| 0.01% | PYXS | PYXIS ONCOLOGY INC | -- | $4,242.70 | 2,755 | BLBR8D5 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $21.12 | 01 | BTFHQP5 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 33.21% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 26,086,223 | -- | 4,587 | -- |
| 31.01% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 24,357,378 | -- | 4,283 | -- |
| 26.80% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 21,053,237 | -- | 3,702 | -- |
| 19.11% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 15,007,967 | -- | 2,639 | -- |
| 14.41% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 11,317,110 | -- | 1,990 | -- |
| 4.58% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,599,865 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $22,835,227.06 | 22,835,227 | -- |
Index
as of 12/31/2025
- Total Number of Companies262
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$7.32 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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