BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 12/31/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 1/13/2026- NAV $81.37
- NAV Change $+0.01
- Market Price $81.35
- Market Price Change $-0.01
- Trading Volume (M) 6,087
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 1/13/2026- NAV $81.37
- NAV Change $+0.01
- Market Price $81.35
- Market Price Change $-0.01
- Trading Volume (M) 6,087
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 12/31/2025
Holdings
as of 1/12/2026
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 6.00% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,173,807.47 | 11,233 | 2931034 |
| 5.50% | GILD | GILEAD SCIENCES INC | -- | $4,743,639.20 | 38,692 | 2369174 |
| 5.32% | AMGN | AMGEN INC | -- | $4,588,811.84 | 14,096 | 2023607 |
| 4.12% | REGN | REGENERON PHARMACEUTICALS | -- | $3,551,232.00 | 4,624 | 2730190 |
| 2.84% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $2,447,581.83 | 26,141 | 2989044 |
| 2.54% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,193,932.65 | 5,915 | B00FWN1 |
| 1.86% | INSM | INSMED INC | -- | $1,601,558.28 | 9,549 | 2614487 |
| 1.41% | BIIB | BIOGEN INC | -- | $1,219,403.47 | 6,569 | 2455965 |
| 1.20% | ARGX | ARGENX SE - ADR | -- | $1,037,984.00 | 1,304 | BDVLM39 |
| 1.18% | RVMD | REVOLUTION MEDICINES INC | -- | $1,014,223.52 | 8,656 | BL71K91 |
| 1.15% | ILMN | ILLUMINA INC | -- | $995,707.55 | 6,841 | 2613990 |
| 1.08% | INCY | INCYTE CORP | -- | $934,640.70 | 8,790 | 2471950 |
| 1.08% | UTHR | UNITED THERAPEUTICS CORP | -- | $930,047.92 | 1,928 | 2430412 |
| 0.89% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $770,133.54 | 19,129 | BMVP7Y0 |
| 0.88% | MEDP | MEDPACE HOLDINGS INC | -- | $755,603.81 | 1,261 | BDCBC61 |
| 0.80% | ROIV | ROIVANT SCIENCES LTD | -- | $690,040.24 | 31,139 | BMW4NZ9 |
| 0.77% | BBIO | BRIDGEBIO PHARMA INC | -- | $662,975.52 | 8,628 | BK1KWG8 |
| 0.76% | VTRS | VIATRIS INC | -- | $653,628.64 | 51,548 | BMWS3X9 |
| 0.72% | GH | GUARDANT HEALTH INC | -- | $623,045.44 | 5,792 | BFXC911 |
| 0.69% | IONS | IONIS PHARMACEUTICALS INC | -- | $592,198.32 | 7,252 | BDJ0LS6 |
| 0.69% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $592,194.24 | 4,464 | 2623911 |
| 0.69% | MRNA | MODERNA INC | -- | $591,760.08 | 17,487 | BGSXTS3 |
| 0.67% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $573,881.24 | 2,749 | BV9G6B8 |
| 0.66% | SMMT | SUMMIT THERAPEUTICS INC | -- | $567,960.24 | 33,331 | BMTVQS7 |
| 0.65% | SNY | SANOFI-ADR | -- | $563,964.80 | 11,848 | 2964557 |
| 0.62% | TEM | TEMPUS AI INC | -- | $536,003.14 | 7,739 | BSLSJJ0 |
| 0.61% | EXEL | EXELIXIS INC | -- | $528,896.24 | 12,004 | 2576941 |
| 0.60% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $519,209.01 | 1,017 | BD59BS7 |
| 0.58% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $495,902.03 | 8,593 | 2437071 |
| 0.57% | RNA | AVIDITY BIOSCIENCES INC | -- | $488,073.10 | 6,746 | BMWHPY1 |
| 0.55% | ONC | BEONE MEDICINES LTD-ADR | -- | $470,591.91 | 1,409 | BYYWPW6 |
| 0.54% | BNTX | BIONTECH SE-ADR | -- | $462,364.50 | 4,525 | BK6H543 |
| 0.52% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $445,373.28 | 2,721 | B4Q5ZN4 |
| 0.46% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $400,920.33 | 6,081 | BYQBFJ8 |
| 0.46% | AXSM | AXSOME THERAPEUTICS INC | -- | $399,082.74 | 2,257 | BYZR4X4 |
| 0.44% | HALO | HALOZYME THERAPEUTICS INC | -- | $381,291.30 | 5,265 | 2975098 |
| 0.43% | CYTK | CYTOKINETICS INC | -- | $374,071.68 | 5,787 | BBBSBJ5 |
| 0.41% | KRYS | KRYSTAL BIOTECH INC | -- | $353,496.87 | 1,299 | BD6JX35 |
| 0.38% | CAI | CARIS LIFE SCIENCES INC | -- | $323,379.20 | 12,632 | BT18HP9 |
| 0.37% | NUVL | NUVALENT INC-A | -- | $320,683.44 | 3,234 | BMVBZD3 |
| 0.36% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $313,411.32 | 2,988 | BF2YWG4 |
| 0.36% | ABVX | ABIVAX SA-ADR | -- | $311,874.00 | 2,643 | BLC89B2 |
| 0.36% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $308,828.80 | 1,120 | BQ721R4 |
| 0.32% | PTCT | PTC THERAPEUTICS INC | -- | $278,858.46 | 3,594 | B17VCN9 |
| 0.31% | PCVX | VAXCYTE INC | -- | $268,851.60 | 5,865 | BKPVGH6 |
| 0.28% | COGT | COGENT BIOSCIENCES INC | -- | $238,801.20 | 6,870 | BLR6XK8 |
| 0.27% | CRSP | CRISPR THERAPEUTICS AG | -- | $235,522.70 | 4,259 | BDHF4K6 |
| 0.27% | KYMR | KYMERA THERAPEUTICS INC | -- | $235,422.89 | 3,221 | BMPRZV5 |
| 0.27% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $235,126.80 | 4,248 | BDD19F8 |
| 0.26% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $224,619.75 | 2,799 | BDCBCD8 |
| 0.25% | ALKS | ALKERMES PLC | -- | $219,069.52 | 7,396 | B3P6D26 |
| 0.24% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $207,871.92 | 2,997 | BQS9486 |
| 0.24% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $205,939.50 | 2,301 | BJDX8Y8 |
| 0.23% | IMVT | IMMUNOVANT INC | -- | $202,505.26 | 7,846 | BJRFSB7 |
| 0.23% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $201,419.25 | 7,575 | 2713317 |
| 0.23% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $198,982.08 | 4,568 | BFZQ0L8 |
| 0.23% | FOLD | AMICUS THERAPEUTICS INC | -- | $197,263.92 | 13,814 | B19FQ48 |
| 0.22% | CGON | CG ONCOLOGY INC | -- | $193,821.76 | 3,608 | BRBCSP4 |
| 0.22% | INDV | INDIVIOR PLC | -- | $193,190.40 | 5,590 | BP0BQQ5 |
| 0.22% | ADMA | ADMA BIOLOGICS INC | -- | $191,062.08 | 10,656 | B9NSBM2 |
| 0.22% | APGE | APOGEE THERAPEUTICS INC | -- | $190,630.75 | 2,455 | BM9HHL5 |
| 0.21% | GRAL | GRAIL INC | -- | $184,953.78 | 1,746 | BSLSSX7 |
| 0.21% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $182,628.60 | 14,070 | BFNF1D6 |
| 0.21% | LGND | LIGAND PHARMACEUTICALS | -- | $182,199.61 | 881 | 2501578 |
| 0.19% | ACLX | ARCELLX INC | -- | $167,948.43 | 2,589 | BPCJ1Q2 |
| 0.19% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $165,934.44 | 5,076 | BP8JSP4 |
| 0.18% | VCYT | VERACYTE INC | -- | $154,030.25 | 3,545 | BFTWZY0 |
| 0.18% | BEAM | BEAM THERAPEUTICS INC | -- | $153,053.67 | 4,543 | BK6L288 |
| 0.17% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $146,861.52 | 5,484 | BKX9VD3 |
| 0.17% | IDYA | IDEAYA BIOSCIENCES INC | -- | $144,597.00 | 3,925 | BK0VHF6 |
| 0.17% | TARS | TARSUS PHARMACEUTICALS INC | -- | $143,582.53 | 1,901 | BMH5RL1 |
| 0.17% | XENE | XENON PHARMACEUTICALS INC | -- | $142,655.80 | 3,460 | BRJ3GY4 |
| 0.16% | TERN | TERNS PHARMACEUTICALS INC | -- | $137,565.63 | 4,033 | BMDJ0C9 |
| 0.16% | TVTX | TRAVERE THERAPEUTICS INC | -- | $136,604.60 | 4,006 | BLFGJD5 |
| 0.15% | IRON | DISC MEDICINE INC | -- | $133,543.80 | 1,690 | BMGJZJ8 |
| 0.15% | VERA | VERA THERAPEUTICS INC | -- | $133,014.98 | 2,863 | BL55460 |
| 0.15% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $131,892.48 | 2,568 | B72ZBG4 |
| 0.15% | APLS | APELLIS PHARMACEUTICALS INC | -- | $131,404.80 | 5,664 | BYTQ6X1 |
| 0.14% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $124,807.10 | 6,835 | BJ5FZ74 |
| 0.14% | DNLI | DENALI THERAPEUTICS INC | -- | $117,877.65 | 6,567 | BD2B4V0 |
| 0.14% | MLYS | MINERALYS THERAPEUTICS INC | -- | $116,881.12 | 3,544 | BP9N0G0 |
| 0.13% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $114,376.20 | 4,740 | BKY5JZ8 |
| 0.13% | IBRX | IMMUNITYBIO INC | -- | $114,219.00 | 44,100 | BNSP0B8 |
| 0.13% | SYRE | SPYRE THERAPEUTICS INC | -- | $113,947.20 | 3,474 | BQBBDY8 |
| 0.13% | DYN | DYNE THERAPEUTICS INC | -- | $111,639.24 | 6,394 | BN15WD1 |
| 0.13% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $110,735.82 | 23,022 | BM9FJ13 |
| 0.12% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $105,254.03 | 4,319 | BJ62Z18 |
| 0.12% | WVE | WAVE LIFE SCIENCES LTD | -- | $104,116.35 | 7,485 | BYZG9R0 |
| 0.12% | TWST | TWIST BIOSCIENCE CORP | -- | $104,077.44 | 2,736 | BGKG6G7 |
| 0.12% | TXG | 10X GENOMICS INC-CLASS A | -- | $103,276.80 | 5,216 | BKS3RS7 |
| 0.12% | OCUL | OCULAR THERAPEUTIX INC | -- | $101,929.15 | 9,535 | BNZB1X8 |
| 0.12% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $101,398.38 | 3,522 | BMZ4LN0 |
| 0.11% | SRPT | SAREPTA THERAPEUTICS INC | -- | $98,935.20 | 4,680 | B8DPDT7 |
| 0.11% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $98,698.33 | 2,579 | BKSGZN7 |
| 0.11% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $95,104.38 | 4,319 | BLB0YQ9 |
| 0.11% | ALMS | ALUMIS INC | -- | $91,804.77 | 4,353 | BPLQG36 |
| 0.10% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $90,197.84 | 5,903 | BFWLC09 |
| 0.10% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $89,349.00 | 3,770 | BMX9K07 |
| 0.10% | GMAB | GENMAB A/S -SP ADR | -- | $88,847.15 | 2,617 | BBC9WC7 |
| 0.10% | MAZE | MAZE THERAPEUTICS INC | -- | $86,569.26 | 2,154 | BSRK699 |
| 0.10% | ANIP | ANI PHARMACEUTICALS INC | -- | $84,856.10 | 1,006 | BCDWBX6 |
| 0.10% | NRIX | NURIX THERAPEUTICS INC | -- | $83,408.44 | 4,538 | BMVLGP2 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $83,144.64 | 2,022 | BRXB0C0 |
| 0.10% | VCEL | VERICEL CORP | -- | $82,876.35 | 2,265 | BSBMN89 |
| 0.10% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $82,445.44 | 5,258 | BRJZSK0 |
| 0.09% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $80,621.52 | 3,891 | BN7Q7R7 |
| 0.09% | ARDX | ARDELYX INC | -- | $80,069.44 | 10,879 | BN89V40 |
| 0.09% | MNKD | MANNKIND CORP | -- | $79,325.96 | 13,748 | BF081J4 |
| 0.09% | HROW | HARROW INC | -- | $79,318.72 | 1,658 | BHNDW86 |
| 0.09% | ERAS | ERASCA INC | -- | $79,133.46 | 12,702 | BNLYBF3 |
| 0.09% | ZYME | ZYMEWORKS INC | -- | $77,586.00 | 3,350 | BPCQZY9 |
| 0.09% | UPB | UPSTREAM BIO INC | -- | $76,617.20 | 2,420 | BRCFFK6 |
| 0.09% | FTRE | FORTREA HOLDINGS INC | -- | $76,120.80 | 4,137 | BRXYZ57 |
| 0.09% | STOK | STOKE THERAPEUTICS INC | -- | $75,226.94 | 2,557 | BJQ05Z6 |
| 0.09% | PHVS | PHARVARIS NV | -- | $74,854.80 | 2,868 | BMZ2X38 |
| 0.09% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $73,943.52 | 2,611 | BCBVTX1 |
| 0.09% | MBX | MBX BIOSCIENCES INC | -- | $73,304.70 | 2,010 | BQXJKH2 |
| 0.08% | SION | SIONNA THERAPEUTICS INC | -- | $72,607.32 | 1,998 | BQKXDX4 |
| 0.08% | NVCR | NOVOCURE LTD | -- | $71,098.52 | 5,014 | BYSS4X4 |
| 0.08% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $69,143.80 | 2,915 | BP7KZP7 |
| 0.08% | ALVO | ALVOTECH SA | -- | $69,093.95 | 14,015 | BPNTJ34 |
| 0.08% | TYRA | TYRA BIOSCIENCES INC | -- | $68,731.53 | 2,389 | BMVNDH9 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $68,132.25 | 1,415 | BX7RSN3 |
| 0.08% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $66,830.34 | 9,426 | 2100362 |
| 0.08% | KOD | KODIAK SCIENCES INC | -- | $66,642.50 | 2,375 | BFXC933 |
| 0.08% | ORKA | ORUKA THERAPEUTICS INC | -- | $66,505.23 | 2,167 | BKVF0J2 |
| 0.08% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $66,504.71 | 2,657 | BMFD115 |
| 0.08% | PGEN | PRECIGEN INC | -- | $65,361.95 | 15,807 | BKM5C84 |
| 0.08% | INVA | INNOVIVA INC | -- | $65,085.12 | 3,348 | BDDXF67 |
| 0.08% | TRVI | TREVI THERAPEUTICS INC | -- | $64,815.89 | 5,741 | BJH9ZN0 |
| 0.07% | TNGX | TANGO THERAPEUTICS INC | -- | $64,279.80 | 6,030 | BP2P6L0 |
| 0.07% | QURE | UNIQURE NV | -- | $64,258.56 | 2,789 | BJFSR88 |
| 0.07% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $63,745.92 | 1,953 | BLCD809 |
| 0.07% | MNMD | MIND MEDICINE MINDMED INC | -- | $61,210.80 | 4,410 | BPQYY97 |
| 0.07% | ATAI | ATAIBECKLEY INC | -- | $61,141.36 | 16,261 | BWJDYK1 |
| 0.07% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $60,921.63 | 4,917 | BPCK358 |
| 0.07% | ANAB | ANAPTYSBIO INC | -- | $60,797.20 | 1,240 | BDRW1L7 |
| 0.07% | ABCL | ABCELLERA BIOLOGICS INC | -- | $60,662.92 | 13,421 | BL53SR3 |
| 0.07% | RLAY | RELAY THERAPEUTICS INC | -- | $60,528.00 | 7,760 | BN2R582 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $60,505.20 | 2,058 | BNFWZS4 |
| 0.07% | TSHA | TAYSHA GENE THERAPIES INC | -- | $59,603.04 | 12,264 | BNC1BX1 |
| 0.07% | NTLA | INTELLIA THERAPEUTICS INC | -- | $59,218.83 | 5,181 | BYZM6C2 |
| 0.07% | EYPT | EYEPOINT INC | -- | $59,089.58 | 3,707 | BMGS7L1 |
| 0.07% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $58,466.23 | 7,429 | BLR7H87 |
| 0.07% | RAPP | RAPPORT THERAPEUTICS INC | -- | $57,672.00 | 2,136 | BR3T9B6 |
| 0.07% | NVAX | NOVAVAX INC | -- | $56,381.25 | 7,275 | BJDQXG4 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $54,621.08 | 11,926 | BMFJJ97 |
| 0.06% | SVRA | SAVARA INC | -- | $52,564.70 | 9,110 | BYXGN81 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $51,835.62 | 1,307 | BKLCWZ3 |
| 0.06% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $51,789.43 | 4,571 | BLB0YH0 |
| 0.06% | SPRY | ARS PHARMACEUTICALS INC | -- | $50,367.88 | 4,426 | BMCR7V2 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $49,922.68 | 5,462 | B8K7T65 |
| 0.06% | SEPN | SEPTERNA INC | -- | $49,884.40 | 2,005 | BQNKXX2 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $49,436.94 | 651 | BNSP8K3 |
| 0.06% | ZBIO | ZENAS BIOPHARMA INC | -- | $47,531.34 | 2,403 | BQB42H3 |
| 0.05% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $46,086.95 | 3,185 | BJLKVS6 |
| 0.05% | XNCR | XENCOR INC | -- | $45,301.49 | 3,197 | BGCYWN8 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $44,959.20 | 2,096 | BZ7PJQ1 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $44,605.50 | 2,270 | BMNDK09 |
| 0.05% | VTYX | VENTYX BIOSCIENCES INC | -- | $44,218.80 | 3,195 | BMG99Y1 |
| 0.05% | PCRX | PACIRA BIOSCIENCES INC | -- | $44,163.18 | 1,926 | B3X26D8 |
| 0.05% | BCAX | BICARA THERAPEUTICS INC | -- | $42,755.79 | 2,453 | BQB42F1 |
| 0.05% | RAPT | RAPT THERAPEUTICS INC | -- | $42,690.40 | 1,241 | BTJZB49 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $42,657.60 | 17,774 | BF0DMK7 |
| 0.05% | GHRS | GH RESEARCH PLC | -- | $42,238.17 | 2,777 | BP6C0S2 |
| 0.05% | MESO | MESOBLAST LTD- SPON ADR | -- | $40,999.32 | 2,196 | BQS7491 |
| 0.05% | GERN | GERON CORP | -- | $40,872.26 | 28,582 | 2370381 |
| 0.05% | OMER | OMEROS CORP | -- | $40,703.50 | 3,175 | B4NB858 |
| 0.05% | ORIC | ORIC PHARMACEUTICALS INC | -- | $39,903.15 | 4,361 | BKVDFF7 |
| 0.04% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $38,749.50 | 8,611 | BZ0QMB7 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $37,995.65 | 10,703 | BBNBTD2 |
| 0.04% | JANX | JANUX THERAPEUTICS INC | -- | $37,782.79 | 2,693 | BMFX8Y7 |
| 0.04% | AVBP | ARRIVENT BIOPHARMA INC | -- | $37,773.12 | 1,848 | BMGTLY5 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $37,106.96 | 2,264 | BD06CS0 |
| 0.04% | VIR | VIR BIOTECHNOLOGY INC | -- | $36,875.68 | 6,229 | BK4PZ38 |
| 0.04% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $36,444.45 | 915 | BL95N25 |
| 0.04% | ANNX | ANNEXON INC | -- | $36,028.80 | 6,480 | BMVV9R5 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $35,662.13 | 3,889 | BYZD465 |
| 0.04% | ARVN | ARVINAS INC | -- | $34,943.40 | 2,876 | BDZ30Q0 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $34,590.96 | 8,082 | BPBJFM7 |
| 0.04% | RGNX | REGENXBIO INC | -- | $34,186.36 | 2,267 | BZ0G875 |
| 0.04% | PSNL | PERSONALIS INC | -- | $34,040.04 | 3,972 | BJQ0608 |
| 0.04% | CTMX | CYTOMX THERAPEUTICS INC | -- | $32,923.24 | 7,586 | BYWVTY5 |
| 0.04% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $32,555.01 | 7,283 | B3MZ6K5 |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $32,487.48 | 813 | BQD3J33 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $32,237.67 | 1,753 | BD9GVY0 |
| 0.04% | IVVD | INVIVYD INC | -- | $30,397.15 | 12,407 | BM8NHS1 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $29,533.00 | 4,219 | BMC3HS7 |
| 0.03% | BIOA | BIOAGE LABS INC | -- | $28,667.10 | 1,606 | BT9K6D8 |
| 0.03% | REPL | REPLIMUNE GROUP INC | -- | $28,464.76 | 3,512 | BDDVW37 |
| 0.03% | CGEM | CULLINAN THERAPEUTICS INC | -- | $28,063.45 | 2,645 | BM90J52 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $27,169.17 | 13,517 | B4N8MH9 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $26,536.16 | 3,268 | BQ6C357 |
| 0.03% | GOSS | GOSSAMER BIO INC | -- | $26,114.76 | 10,363 | BJ0CK86 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $26,092.96 | 3,604 | BFYQFJ2 |
| 0.03% | KROS | KEROS THERAPEUTICS INC | -- | $25,752.32 | 1,364 | BM7V485 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $25,586.36 | 6,494 | BMCWKZ2 |
| 0.03% | CRMD | CORMEDIX INC | -- | $25,225.20 | 3,528 | BJ0LT31 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $23,256.00 | 2,550 | BMFK3H6 |
| 0.03% | FULC | FULCRUM THERAPEUTICS INC | -- | $23,042.73 | 2,423 | BJDX8Z9 |
| 0.03% | ABSI | ABSCI CORP | -- | $22,892.20 | 6,733 | BN94K69 |
| 0.03% | LYEL | LYELL IMMUNOPHARMA INC | -- | $22,581.50 | 950 | BTNMG41 |
| 0.03% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $22,572.00 | 3,344 | BYP80F1 |
| 0.03% | LENZ | LENZ THERAPEUTICS INC | -- | $21,813.57 | 1,401 | BQV0J03 |
| 0.02% | PRTA | PROTHENA CORP PLC | -- | $21,482.01 | 2,411 | B91XRN2 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $21,455.28 | 648 | B292NQ7 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $21,127.54 | 3,206 | 2107437 |
| 0.02% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $21,125.98 | 2,521 | BLFBZ32 |
| 0.02% | KMDA | KAMADA LTD | -- | $20,818.98 | 2,583 | B2Q9833 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $19,606.86 | 2,646 | B12W3P6 |
| 0.02% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $19,192.50 | 2,559 | BKLXFX5 |
| 0.02% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $19,175.13 | 5,463 | BYVQJ96 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $18,921.60 | 4,672 | BFY7DC4 |
| 0.02% | ETON | ETON PHARMACEUTICALS INC | -- | $18,579.47 | 1,201 | BGL0JK3 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $18,277.12 | 3,488 | BQHN6C7 |
| 0.02% | PEPG | PEPGEN INC | -- | $17,488.72 | 3,079 | BMTX3D7 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $17,442.00 | 4,845 | BDFKQ07 |
| 0.02% | NBP | NOVABRIDGE BIOSCIENCES | -- | $17,316.60 | 4,655 | BKRRKY7 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $17,160.00 | 4,000 | BYTYP72 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $17,024.45 | 1,711 | BP81RK8 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $16,803.54 | 10,062 | BFZNYB7 |
| 0.02% | EOLS | EVOLUS INC | -- | $16,744.54 | 2,902 | BDRJH21 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $16,679.72 | 1,292 | B9L5200 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $16,607.82 | 7,481 | BN4JN37 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $16,424.80 | 838 | BPBPCG8 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $16,171.95 | 1,965 | BSMLR16 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $16,154.16 | 2,532 | BMF7DT9 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $15,825.92 | 4,496 | BZC0D70 |
| 0.02% | AARD | AARDVARK THERAPEUTICS INC | -- | $14,469.00 | 975 | BTXQTX3 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $14,414.01 | 2,843 | BP81R42 |
| 0.02% | CADL | CANDEL THERAPEUTICS INC | -- | $14,403.88 | 2,458 | BP0TQC5 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $14,167.68 | 2,256 | B7F2TY6 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $13,633.76 | 2,072 | BKDQKM6 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $13,471.50 | 8,981 | BFMLGR4 |
| 0.01% | ACRS | ACLARIS THERAPEUTICS INC | -- | $12,903.66 | 4,851 | BYV2W40 |
| 0.01% | LFCR | LIFECORE BIOMEDICAL INC | -- | $12,736.02 | 1,678 | 2517058 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $12,627.78 | 3,498 | BLN9Z50 |
| 0.01% | LRMR | LARIMAR THERAPEUTICS INC | -- | $12,454.00 | 3,832 | BMXNGZ6 |
| 0.01% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $12,401.80 | 2,102 | BL5B6Z1 |
| 0.01% | OABI | OMNIAB INC | -- | $12,309.95 | 6,445 | BN13S71 |
| 0.01% | IMRX | IMMUNEERING CORP - CLASS A | -- | $12,200.02 | 2,891 | BMVBZF5 |
| 0.01% | MENS | JYONG BIOTECH LTD | -- | $12,118.24 | 3,404 | BPTK6Z2 |
| 0.01% | NGNE | NEUROGENE INC | -- | $11,975.04 | 693 | BS2F741 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $11,780.48 | 2,528 | BPRB2N7 |
| 0.01% | VOR | VOR BIOPHARMA INC | -- | $10,669.10 | 754 | BRJJYT3 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $10,593.55 | 8,755 | BNR5QT9 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $10,303.80 | 2,642 | BY7RB53 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $9,943.40 | 2,396 | BP7L561 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $9,578.16 | 1,272 | BKC9SX3 |
| 0.01% | CABA | CABALETTA BIO INC | -- | $9,525.10 | 4,310 | BK5MWR1 |
| 0.01% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $9,481.78 | 1,034 | BPRBTY7 |
| 0.01% | HUMA | HUMACYTE INC | -- | $9,475.05 | 8,385 | BMYTJP4 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $9,310.23 | 4,371 | BZ8FPH3 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $9,244.20 | 4,340 | BKX9NQ0 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $8,929.80 | 5,412 | BRK0149 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $8,661.12 | 1,388 | BP2NYN2 |
| 0.01% | CDXS | CODEXIS INC | -- | $6,795.60 | 4,045 | B5LL2C2 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $6,734.64 | 2,551 | BKTV702 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $6,610.72 | 4,184 | BNYJR68 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $6,506.83 | 4,367 | BNNXX18 |
| 0.01% | PYXS | PYXIS ONCOLOGY INC | -- | $5,743.28 | 2,788 | BLBR8D5 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $5,495.83 | 7,455 | BNNXX52 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $11.33 | 01 | BTFHQP5 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 38.81% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 33,463,923 | -- | 5,795 | -- |
| 32.67% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 28,168,596 | -- | 4,878 | -- |
| 22.09% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 19,044,697 | -- | 3,298 | -- |
| 16.63% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,344,156 | -- | 2,484 | -- |
| 15.40% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 13,275,851 | -- | 2,299 | -- |
| 4.24% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,655,334 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $25,836,730.24 | 25,836,730 | -- |
Index
as of 12/31/2025
- Total Number of Companies262
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$7.32 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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