BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
View fund details
Documents & Downloads
You may order paper copies by contacting ProShares Client Services at 866-PRO-5125 (866-776-5125)
Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 10/31/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 20.05% | 41.93% | 51.59% | 42.58% | 20.67% | 9.55% | 2.60% | 0.91% | 15.79% | 04/07/2010 |
| BIB Market Price | 20.06% | 42.12% | 51.73% | 42.51% | 20.92% | 9.51% | 2.55% | 0.91% | 15.79% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/02/2025- NAV $78.85
- NAV Change $-1.08
- Market Price $78.87
- Market Price Change $-1.03
- Trading Volume (M) 21,317
- 30-Day Median Bid Ask Spread 0.27%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/02/2025- NAV $78.85
- NAV Change $-1.08
- Market Price $78.87
- Market Price Change $-1.03
- Trading Volume (M) 21,317
- 30-Day Median Bid Ask Spread 0.27%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 12/02/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.51% | AMGN | AMGEN INC | -- | $4,603,049.44 | 13,604 | 2023607 |
| 5.19% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $4,335,831.50 | 10,010 | 2931034 |
| 5.14% | GILD | GILEAD SCIENCES INC | -- | $4,293,481.50 | 34,650 | 2369174 |
| 4.34% | REGN | REGENERON PHARMACEUTICALS | -- | $3,626,154.00 | 4,887 | 2730190 |
| 3.42% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,858,854.57 | 6,149 | B00FWN1 |
| 2.64% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $2,208,533.81 | 24,493 | 2989044 |
| 2.47% | INSM | INSMED INC | -- | $2,065,793.40 | 9,999 | 2614487 |
| 1.58% | ARGX | ARGENX SE - ADR | -- | $1,324,525.92 | 1,447 | BDVLM39 |
| 1.50% | BIIB | BIOGEN INC | -- | $1,249,548.30 | 6,935 | 2455965 |
| 1.21% | UTHR | UNITED THERAPEUTICS CORP | -- | $1,014,185.46 | 2,139 | 2430412 |
| 1.12% | INCY | INCYTE CORP | -- | $936,899.84 | 9,236 | 2471950 |
| 1.11% | ILMN | ILLUMINA INC | -- | $927,288.50 | 7,270 | 2613990 |
| 0.97% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $808,269.91 | 20,447 | BMVP7Y0 |
| 0.93% | MEDP | MEDPACE HOLDINGS INC | -- | $775,737.30 | 1,329 | BDCBC61 |
| 0.86% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $715,131.20 | 4,690 | 2623911 |
| 0.80% | RVMD | REVOLUTION MEDICINES INC | -- | $665,891.02 | 8,842 | BL71K91 |
| 0.78% | ROIV | ROIVANT SCIENCES LTD | -- | $649,230.00 | 32,300 | BMW4NZ9 |
| 0.77% | BBIO | BRIDGEBIO PHARMA INC | -- | $646,069.86 | 9,041 | BK1KWG8 |
| 0.76% | SNY | SANOFI-ADR | -- | $632,746.05 | 12,693 | 2964557 |
| 0.73% | IONS | IONIS PHARMACEUTICALS INC | -- | $612,914.78 | 7,538 | BDJ0LS6 |
| 0.73% | GH | GUARDANT HEALTH INC | -- | $612,729.13 | 5,899 | BFXC911 |
| 0.73% | SMMT | SUMMIT THERAPEUTICS INC | -- | $606,096.00 | 35,136 | BMTVQS7 |
| 0.72% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $605,819.55 | 1,057 | BD59BS7 |
| 0.71% | VTRS | VIATRIS INC | -- | $590,592.24 | 55,144 | BMWS3X9 |
| 0.71% | TEM | TEMPUS AI INC | -- | $590,132.66 | 7,978 | BSLSJJ0 |
| 0.69% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $580,401.36 | 2,871 | BV9G6B8 |
| 0.66% | EXEL | EXELIXIS INC | -- | $553,078.08 | 12,732 | 2576941 |
| 0.63% | ONC | BEONE MEDICINES LTD-ADR | -- | $524,994.15 | 1,590 | BYYWPW6 |
| 0.59% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $489,321.20 | 9,080 | 2437071 |
| 0.57% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $478,124.28 | 2,868 | B4Q5ZN4 |
| 0.55% | BNTX | BIONTECH SE-ADR | -- | $457,291.38 | 4,758 | BK6H543 |
| 0.53% | MRNA | MODERNA INC | -- | $442,776.18 | 18,403 | BGSXTS3 |
| 0.52% | RNA | AVIDITY BIOSCIENCES INC | -- | $435,320.90 | 6,085 | BMWHPY1 |
| 0.45% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $378,993.00 | 6,540 | BYQBFJ8 |
| 0.44% | HALO | HALOZYME THERAPEUTICS INC | -- | $368,099.28 | 5,532 | 2975098 |
| 0.43% | CYTK | CYTOKINETICS INC | -- | $359,466.60 | 5,660 | BBBSBJ5 |
| 0.41% | MRUS | MERUS NV | -- | $343,356.23 | 3,577 | BZBY005 |
| 0.40% | AXSM | AXSOME THERAPEUTICS INC | -- | $335,474.49 | 2,361 | BYZR4X4 |
| 0.40% | NUVL | NUVALENT INC-A | -- | $331,043.84 | 3,154 | BMVBZD3 |
| 0.38% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $318,567.38 | 3,142 | BF2YWG4 |
| 0.35% | PTCT | PTC THERAPEUTICS INC | -- | $294,984.21 | 3,758 | B17VCN9 |
| 0.35% | KRYS | KRYSTAL BIOTECH INC | -- | $294,202.08 | 1,368 | BD6JX35 |
| 0.33% | PCVX | VAXCYTE INC | -- | $274,502.70 | 6,141 | BKPVGH6 |
| 0.31% | COGT | COGENT BIOSCIENCES INC | -- | $257,579.84 | 6,608 | BLR6XK8 |
| 0.30% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $249,040.30 | 2,942 | BDCBCD8 |
| 0.27% | ALKS | ALKERMES PLC | -- | $226,197.76 | 7,808 | B3P6D26 |
| 0.27% | CRSP | CRISPR THERAPEUTICS AG | -- | $221,484.52 | 4,294 | BDHF4K6 |
| 0.26% | KYMR | KYMERA THERAPEUTICS INC | -- | $217,361.14 | 3,382 | BMPRZV5 |
| 0.26% | ADMA | ADMA BIOLOGICS INC | -- | $217,274.75 | 11,287 | B9NSBM2 |
| 0.25% | AKRO | AKERO THERAPEUTICS INC | -- | $206,190.16 | 3,784 | BK7Y2V9 |
| 0.24% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $204,145.58 | 5,326 | BP8JSP4 |
| 0.24% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $202,931.40 | 7,980 | 2713317 |
| 0.24% | INDV | INDIVIOR PLC | -- | $200,668.00 | 5,902 | BP0BQQ5 |
| 0.24% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $200,474.54 | 4,454 | BDD19F8 |
| 0.22% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $186,831.84 | 4,548 | BFZQ0L8 |
| 0.22% | IMVT | IMMUNOVANT INC | -- | $181,532.88 | 8,244 | BJRFSB7 |
| 0.22% | LGND | LIGAND PHARMACEUTICALS | -- | $180,857.70 | 927 | 2501578 |
| 0.22% | ACLX | ARCELLX INC | -- | $180,488.63 | 2,623 | BPCJ1Q2 |
| 0.21% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $178,398.54 | 996 | BQ721R4 |
| 0.21% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $178,260.00 | 14,855 | BFNF1D6 |
| 0.21% | VCYT | VERACYTE INC | -- | $171,761.36 | 3,721 | BFTWZY0 |
| 0.20% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $166,809.24 | 5,668 | BKX9VD3 |
| 0.20% | GRAL | GRAIL INC | -- | $166,130.28 | 1,706 | BSLSSX7 |
| 0.20% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $166,034.88 | 2,376 | BJDX8Y8 |
| 0.19% | TARS | TARSUS PHARMACEUTICALS INC | -- | $158,562.24 | 1,996 | BMH5RL1 |
| 0.19% | XENE | XENON PHARMACEUTICALS INC | -- | $156,383.36 | 3,647 | BRJ3GY4 |
| 0.18% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $152,589.73 | 4,559 | BJ62Z18 |
| 0.18% | APGE | APOGEE THERAPEUTICS INC | -- | $150,841.66 | 2,182 | BM9HHL5 |
| 0.18% | CGON | CG ONCOLOGY INC | -- | $149,221.59 | 3,607 | BRBCSP4 |
| 0.18% | IRON | DISC MEDICINE INC | -- | $147,409.96 | 1,643 | BMGJZJ8 |
| 0.17% | TVTX | TRAVERE THERAPEUTICS INC | -- | $143,267.85 | 4,215 | BLFGJD5 |
| 0.17% | FOLD | AMICUS THERAPEUTICS INC | -- | $141,863.40 | 14,580 | B19FQ48 |
| 0.17% | IDYA | IDEAYA BIOSCIENCES INC | -- | $139,611.36 | 4,144 | BK0VHF6 |
| 0.16% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $134,605.38 | 7,202 | BJ5FZ74 |
| 0.16% | DYN | DYNE THERAPEUTICS INC | -- | $134,492.72 | 6,728 | BN15WD1 |
| 0.15% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $129,292.85 | 4,535 | BLB0YQ9 |
| 0.15% | APLS | APELLIS PHARMACEUTICALS INC | -- | $123,422.84 | 5,974 | BYTQ6X1 |
| 0.15% | DNLI | DENALI THERAPEUTICS INC | -- | $123,399.28 | 6,917 | BD2B4V0 |
| 0.15% | MLYS | MINERALYS THERAPEUTICS INC | -- | $122,774.40 | 3,136 | BP9N0G0 |
| 0.14% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $117,050.36 | 2,653 | B72ZBG4 |
| 0.14% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $114,509.34 | 4,983 | BKY5JZ8 |
| 0.13% | VERA | VERA THERAPEUTICS INC | -- | $112,420.50 | 3,018 | BL55460 |
| 0.13% | BEAM | BEAM THERAPEUTICS INC | -- | $111,848.82 | 4,786 | BK6L288 |
| 0.13% | TERN | TERNS PHARMACEUTICALS INC | -- | $106,590.07 | 4,133 | BMDJ0C9 |
| 0.13% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $106,279.58 | 3,982 | BMX9K07 |
| 0.12% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $99,055.66 | 6,226 | BFWLC09 |
| 0.12% | AVDL | AVADEL PHARMACEUTICALS | -- | $98,039.20 | 4,592 | BDGMC59 |
| 0.12% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $97,947.20 | 2,720 | BKSGZN7 |
| 0.12% | TXG | 10X GENOMICS INC-CLASS A | -- | $97,091.28 | 5,412 | BKS3RS7 |
| 0.11% | SRPT | SAREPTA THERAPEUTICS INC | -- | $94,632.81 | 4,623 | B8DPDT7 |
| 0.11% | IBRX | IMMUNITYBIO INC | -- | $93,441.81 | 44,709 | BNSP0B8 |
| 0.11% | OCUL | OCULAR THERAPEUTIX INC | -- | $92,576.25 | 8,229 | BNZB1X8 |
| 0.11% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $90,546.28 | 2,819 | BQS9486 |
| 0.11% | VCEL | VERICEL CORP | -- | $89,832.90 | 2,386 | BSBMN89 |
| 0.11% | ZYME | ZYMEWORKS INC | -- | $89,230.50 | 3,555 | BPCQZY9 |
| 0.11% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $88,128.90 | 3,246 | BMZ4LN0 |
| 0.10% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $87,315.84 | 20,212 | BM9FJ13 |
| 0.10% | TWST | TWIST BIOSCIENCE CORP | -- | $84,793.50 | 2,855 | BGKG6G7 |
| 0.10% | ANIP | ANI PHARMACEUTICALS INC | -- | $84,255.12 | 1,026 | BCDWBX6 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $82,383.92 | 2,056 | BRXB0C0 |
| 0.10% | SYRE | SPYRE THERAPEUTICS INC | -- | $81,138.80 | 2,857 | BQBBDY8 |
| 0.10% | MNKD | MANNKIND CORP | -- | $81,127.67 | 14,513 | BF081J4 |
| 0.09% | STOK | STOKE THERAPEUTICS INC | -- | $77,267.52 | 2,592 | BJQ05Z6 |
| 0.09% | TRVI | TREVI THERAPEUTICS INC | -- | $76,896.00 | 5,760 | BJH9ZN0 |
| 0.09% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $76,569.25 | 4,075 | BN7Q7R7 |
| 0.09% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $74,302.92 | 2,754 | BCBVTX1 |
| 0.09% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $71,098.80 | 9,930 | 2100362 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $70,789.90 | 1,490 | BX7RSN3 |
| 0.08% | HROW | HARROW INC | -- | $70,297.50 | 1,750 | BHNDW86 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $68,505.98 | 1,894 | BLCD809 |
| 0.08% | ALVO | ALVOTECH SA | -- | $68,098.40 | 14,804 | BPNTJ34 |
| 0.08% | QURE | UNIQURE NV | -- | $65,705.40 | 2,595 | BJFSR88 |
| 0.08% | ARDX | ARDELYX INC | -- | $63,144.92 | 11,398 | BN89V40 |
| 0.08% | GMAB | GENMAB A/S -SP ADR | -- | $62,880.93 | 1,983 | BBC9WC7 |
| 0.07% | INVA | INNOVIVA INC | -- | $62,541.38 | 2,981 | BDDXF67 |
| 0.07% | RLAY | RELAY THERAPEUTICS INC | -- | $61,073.46 | 8,154 | BN2R582 |
| 0.07% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $60,340.48 | 5,546 | BRJZSK0 |
| 0.07% | NRIX | NURIX THERAPEUTICS INC | -- | $59,088.90 | 3,614 | BMVLGP2 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $58,647.33 | 2,199 | BNFWZS4 |
| 0.07% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $57,942.50 | 4,214 | BPCK358 |
| 0.07% | NVCR | NOVOCURE LTD | -- | $57,744.96 | 5,288 | BYSS4X4 |
| 0.07% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $57,588.56 | 2,801 | BMFD115 |
| 0.07% | INBX | INHIBRX BIOSCIENCES INC | -- | $56,423.50 | 686 | BNSP8K3 |
| 0.07% | FTRE | FORTREA HOLDINGS INC | -- | $54,748.50 | 4,294 | BRXYZ57 |
| 0.07% | CVAC | CUREVAC NV | -- | $54,421.50 | 10,650 | BN4RD42 |
| 0.06% | ANAB | ANAPTYSBIO INC | -- | $54,192.50 | 1,325 | BDRW1L7 |
| 0.06% | XNCR | XENCOR INC | -- | $53,950.26 | 3,374 | BGCYWN8 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $53,606.10 | 1,371 | BKLCWZ3 |
| 0.06% | URGN | UROGEN PHARMA LTD | -- | $53,367.82 | 2,189 | BZ7PJQ1 |
| 0.06% | TNGX | TANGO THERAPEUTICS INC | -- | $53,051.04 | 5,263 | BP2P6L0 |
| 0.06% | TYRA | TYRA BIOSCIENCES INC | -- | $52,739.32 | 2,521 | BMVNDH9 |
| 0.06% | WVE | WAVE LIFE SCIENCES LTD | -- | $52,613.73 | 7,527 | BYZG9R0 |
| 0.06% | TSHA | TAYSHA GENE THERAPIES INC | -- | $52,382.12 | 12,902 | BNC1BX1 |
| 0.06% | PCRX | PACIRA BIOSCIENCES INC | -- | $51,148.75 | 2,125 | B3X26D8 |
| 0.06% | NVAX | NOVAVAX INC | -- | $50,701.20 | 7,682 | BJDQXG4 |
| 0.06% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $49,452.70 | 3,355 | BJLKVS6 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $49,417.86 | 7,638 | BLR7H87 |
| 0.06% | ORKA | ORUKA THERAPEUTICS INC | -- | $49,286.93 | 1,771 | BKVF0J2 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $49,102.70 | 5,770 | B8K7T65 |
| 0.06% | PGEN | PRECIGEN INC | -- | $49,043.64 | 14,093 | BKM5C84 |
| 0.06% | ORIC | ORIC PHARMACEUTICALS INC | -- | $48,915.45 | 4,593 | BKVDFF7 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $48,903.64 | 14,134 | BL53SR3 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $48,576.92 | 12,236 | BMFJJ97 |
| 0.06% | SVRA | SAVARA INC | -- | $47,502.56 | 8,176 | BYXGN81 |
| 0.06% | RAPP | RAPPORT THERAPEUTICS INC | -- | $46,836.24 | 1,727 | BR3T9B6 |
| 0.05% | KURA | KURA ONCOLOGY INC | -- | $45,688.65 | 4,105 | BYZD465 |
| 0.05% | JANX | JANUX THERAPEUTICS INC | -- | $45,074.12 | 2,842 | BMFX8Y7 |
| 0.05% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $45,012.61 | 2,921 | BP7KZP7 |
| 0.05% | EYPT | EYEPOINT PHARMACEUTICALS INC | -- | $44,629.40 | 3,260 | BMGS7L1 |
| 0.05% | ZLAB | ZAI LAB LTD-ADR | -- | $44,154.24 | 2,262 | BD9GVY0 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $43,900.26 | 2,382 | BMNDK09 |
| 0.05% | MNMD | MIND MEDICINE MINDMED INC | -- | $43,488.36 | 3,606 | BPQYY97 |
| 0.05% | PSNL | PERSONALIS INC | -- | $42,359.40 | 4,194 | BJQ0608 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $42,252.96 | 4,674 | BMCR7V2 |
| 0.05% | NTLA | INTELLIA THERAPEUTICS INC | -- | $41,123.70 | 5,077 | BYZM6C2 |
| 0.05% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $40,834.92 | 4,844 | BLB0YH0 |
| 0.05% | ARVN | ARVINAS INC | -- | $40,495.18 | 3,473 | BDZ30Q0 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $39,798.50 | 1,918 | BMGTLY5 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $39,174.84 | 963 | BL95N25 |
| 0.05% | ERAS | ERASCA INC | -- | $38,775.13 | 13,417 | BNLYBF3 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $37,809.39 | 9,067 | BZ0QMB7 |
| 0.05% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $37,704.09 | 849 | BQD3J33 |
| 0.04% | GERN | GERON CORP | -- | $37,117.71 | 30,177 | 2370381 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $37,000.81 | 2,233 | BQS7491 |
| 0.04% | VIR | VIR BIOTECHNOLOGY INC | -- | $36,989.10 | 6,570 | BK4PZ38 |
| 0.04% | REPL | REPLIMUNE GROUP INC | -- | $36,920.00 | 3,692 | BDDVW37 |
| 0.04% | LENZ | LENZ THERAPEUTICS INC | -- | $36,841.19 | 1,349 | BQV0J03 |
| 0.04% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $36,542.66 | 17,116 | BF0DMK7 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $34,905.42 | 9,537 | BBNBTD2 |
| 0.04% | CRMD | CORMEDIX INC | -- | $34,533.18 | 3,531 | BJ0LT31 |
| 0.04% | ALMS | ALUMIS INC | -- | $33,952.62 | 4,582 | BPLQG36 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $33,925.53 | 5,721 | BYVQJ96 |
| 0.04% | ATXS | ASTRIA THERAPEUTICS INC | -- | $33,642.00 | 2,670 | BMYRFN8 |
| 0.04% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $32,960.24 | 14,207 | B4N8MH9 |
| 0.04% | KROS | KEROS THERAPEUTICS INC | -- | $32,313.60 | 1,920 | BM7V485 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $32,191.12 | 2,381 | BD06CS0 |
| 0.04% | OMER | OMEROS CORP | -- | $30,355.17 | 3,219 | B4NB858 |
| 0.04% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $29,488.75 | 3,805 | BFYQFJ2 |
| 0.04% | RGNX | REGENXBIO INC | -- | $29,279.58 | 2,398 | BZ0G875 |
| 0.03% | CGEM | CULLINAN THERAPEUTICS INC | -- | $28,488.60 | 2,793 | BM90J52 |
| 0.03% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $28,376.25 | 3,525 | BYP80F1 |
| 0.03% | PRME | PRIME MEDICINE INC | -- | $27,294.30 | 8,271 | BPBJFM7 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $26,887.00 | 7,682 | B3MZ6K5 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $26,351.10 | 2,546 | B91XRN2 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $24,075.42 | 2,693 | BMFK3H6 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $23,543.36 | 6,844 | BMCWKZ2 |
| 0.03% | LXRX | LEXICON PHARMACEUTICALS INC | -- | $23,033.26 | 17,189 | BWFZX59 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $22,377.17 | 2,209 | BKLXFX5 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $21,699.52 | 2,656 | BLFBZ32 |
| 0.03% | ABSI | ABSCI CORP | -- | $21,431.19 | 7,073 | BN94K69 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $21,429.72 | 4,338 | BMC3HS7 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $21,255.30 | 678 | B292NQ7 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $21,249.28 | 2,554 | BQ6C357 |
| 0.03% | ANNX | ANNEXON INC | -- | $21,079.52 | 5,192 | BMVV9R5 |
| 0.03% | HCM | HUTCHMED CHINA-ADR | -- | $20,933.68 | 1,468 | BYXV9H7 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $20,084.91 | 3,387 | 2107437 |
| 0.02% | EOLS | EVOLUS INC | -- | $19,951.20 | 3,060 | BDRJH21 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $19,873.00 | 4,175 | BFY7DC4 |
| 0.02% | LYEL | LYELL IMMUNOPHARMA INC | -- | $18,937.10 | 910 | BTNMG41 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $18,788.40 | 3,684 | BQHN6C7 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $17,730.00 | 1,800 | BP81RK8 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $17,686.76 | 2,938 | BP81R42 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $17,081.80 | 7,660 | BN4JN37 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $16,832.70 | 885 | BPBPCG8 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $15,771.36 | 5,104 | BDFKQ07 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $15,004.08 | 2,184 | BKDQKM6 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $14,907.54 | 4,062 | BYTYP72 |
| 0.02% | AMRN | AMARIN CORP PLC -ADR | -- | $14,800.09 | 953 | BN72KB0 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $14,127.52 | 1,012 | B9L5200 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $14,063.30 | 10,495 | BFZNYB7 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $13,968.75 | 2,235 | BL5B6Z1 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $13,746.48 | 2,794 | B12W3P6 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $13,421.76 | 2,046 | BSMLR16 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $13,071.63 | 4,719 | BZC0D70 |
| 0.02% | NGNE | NEUROGENE INC | -- | $13,006.24 | 676 | BS2F741 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $12,711.24 | 9,486 | BFMLGR4 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $12,629.76 | 4,048 | BMXNGZ6 |
| 0.01% | FHTX | FOGHORN THERAPEUTICS INC | -- | $11,471.46 | 2,674 | BMF7DT9 |
| 0.01% | PYXS | PYXIS ONCOLOGY INC | -- | $11,468.03 | 2,933 | BLBR8D5 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $11,262.00 | 3,754 | BLN9Z50 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $11,187.02 | 2,531 | BP7L561 |
| 0.01% | OABI | OMNIAB INC | -- | $9,923.13 | 5,803 | BN13S71 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $9,888.71 | 2,623 | BY7RB53 |
| 0.01% | HUMA | HUMACYTE INC | -- | $9,438.66 | 7,491 | BMYTJP4 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $8,973.83 | 4,253 | BZ8FPH3 |
| 0.01% | RNAC | CARTESIAN THERAPEUTICS INC | -- | $8,260.01 | 1,231 | BQB9HM8 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $8,181.81 | 3,367 | BKX9NQ0 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $8,025.00 | 1,284 | BKC9SX3 |
| 0.01% | MXCT | MAXCYTE INC | -- | $7,917.51 | 5,043 | BKMQF66 |
| 0.01% | PEPG | PEPGEN INC | -- | $7,915.20 | 1,552 | BMTX3D7 |
| 0.01% | CDXS | CODEXIS INC | -- | $7,043.85 | 4,269 | B5LL2C2 |
| 0.01% | MRSN | MERSANA THERAPEUTICS INC | -- | $6,494.72 | 236 | BVPKH99 |
| 0.01% | NKTX | NKARTA INC | -- | $5,846.40 | 3,360 | BK80YJ8 |
| 0.01% | FATE | FATE THERAPEUTICS INC | -- | $5,482.28 | 5,455 | BCZS820 |
| 0.01% | ALEC | ALECTOR INC | -- | $5,458.32 | 4,788 | BJ4LDC4 |
| 0.01% | CLYM | CLIMB BIO INC | -- | $5,257.84 | 3,206 | BMW5LX6 |
| 0.01% | PLRX | PLIANT THERAPEUTICS INC | -- | $4,326.96 | 2,904 | BMDWW66 |
| 0.01% | MGNX | MACROGENICS INC | -- | $4,245.80 | 2,990 | BFDV8K0 |
| -- | ARTV | ARTIVA BIOTHERAPEUTICS INC | -- | $3,861.04 | 1,156 | BMF1LJ7 |
| -- | TVGN | TEVOGEN BIO HOLDINGS INC | -- | $3,583.90 | 9,304 | BPG5P75 |
| -- | ACRV | ACRIVON THERAPEUTICS INC | -- | $3,273.60 | 1,488 | BP2TPK4 |
| -- | -- | SUTRO BIOPHARMA INC COMMON STOCK USD 0.001 | -- | $2,926.50 | 401 | -- |
| -- | BMEA | BIOMEA FUSION INC | -- | $2,694.80 | 2,815 | BNKF6N0 |
| -- | TCRX | TSCAN THERAPEUTICS INC | -- | $2,362.41 | 2,481 | BNLYBJ7 |
| -- | QTTB | Q32 BIO INC | -- | $1,964.16 | 576 | BS2FKQ4 |
| -- | OKUR | ONKURE THERAPEUTICS INC-A | -- | $1,592.96 | 608 | BT7KGT6 |
| -- | APLT | APPLIED THERAPEUTICS INC | -- | $1,450.06 | 6,811 | BJL38Z1 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 36.95% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 30,880,619 | -- | 5,462 | -- |
| 33.88% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 28,313,830 | -- | 5,008 | -- |
| 22.72% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 18,990,845 | -- | 3,359 | -- |
| 16.80% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,043,840 | -- | 2,484 | -- |
| 15.55% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 12,997,902 | -- | 2,299 | -- |
| 4.28% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,578,805 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $25,181,066.63 | 25,181,067 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
Read More