BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 12/31/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 2/02/2026- NAV $84.99
- NAV Change $+1.82
- Market Price $84.97
- Market Price Change $+1.84
- Trading Volume (M) 8,614
- 30-Day Median Bid Ask Spread 0.28%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 2/02/2026- NAV $84.99
- NAV Change $+1.82
- Market Price $84.97
- Market Price Change $+1.84
- Trading Volume (M) 8,614
- 30-Day Median Bid Ask Spread 0.28%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 12/31/2025
Holdings
as of 2/02/2026
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 6.48% | GILD | GILEAD SCIENCES INC | -- | $5,781,758.07 | 40,463 | 2369174 |
| 6.21% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,542,813.43 | 11,743 | 2931034 |
| 5.69% | AMGN | AMGEN INC | -- | $5,080,238.52 | 14,739 | 2023607 |
| 4.09% | REGN | REGENERON PHARMACEUTICALS | -- | $3,651,276.72 | 4,836 | 2730190 |
| 2.35% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,097,734.46 | 6,186 | B00FWN1 |
| 1.72% | INSM | INSMED INC | -- | $1,537,644.28 | 9,986 | 2614487 |
| 1.38% | BIIB | BIOGEN INC | -- | $1,230,169.21 | 6,869 | 2455965 |
| 1.28% | ARGX | ARGENX SE - ADR | -- | $1,139,031.84 | 1,363 | BDVLM39 |
| 1.13% | ILMN | ILLUMINA INC | -- | $1,009,644.02 | 7,154 | 2613990 |
| 1.07% | UTHR | UNITED THERAPEUTICS CORP | -- | $957,600.00 | 2,016 | 2430412 |
| 1.06% | INCY | INCYTE CORP | -- | $943,742.64 | 9,192 | 2471950 |
| 0.99% | RVMD | REVOLUTION MEDICINES INC | -- | $879,492.32 | 9,052 | BL71K91 |
| 0.95% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $847,411.80 | 20,005 | BMVP7Y0 |
| 0.87% | MRNA | MODERNA INC | -- | $778,324.60 | 18,292 | BGSXTS3 |
| 0.87% | MEDP | MEDPACE HOLDINGS INC | -- | $775,796.23 | 1,319 | BDCBC61 |
| 0.83% | VTRS | VIATRIS INC | -- | $737,735.04 | 53,928 | BMWS3X9 |
| 0.80% | ROIV | ROIVANT SCIENCES LTD | -- | $714,454.16 | 32,564 | BMW4NZ9 |
| 0.79% | BBIO | BRIDGEBIO PHARMA INC | -- | $705,881.28 | 9,022 | BK1KWG8 |
| 0.78% | GH | GUARDANT HEALTH INC | -- | $696,064.20 | 6,058 | BFXC911 |
| 0.72% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $642,821.25 | 2,875 | BV9G6B8 |
| 0.72% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $642,456.84 | 4,668 | 2623911 |
| 0.71% | IONS | IONIS PHARMACEUTICALS INC | -- | $630,002.88 | 7,584 | BDJ0LS6 |
| 0.66% | SNY | SANOFI-ADR | -- | $585,675.30 | 12,390 | 2964557 |
| 0.60% | EXEL | EXELIXIS INC | -- | $537,436.74 | 12,554 | 2576941 |
| 0.58% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $521,260.25 | 8,995 | 2437071 |
| 0.58% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $520,582.99 | 1,063 | BD59BS7 |
| 0.58% | BNTX | BIONTECH SE-ADR | -- | $515,437.92 | 4,734 | BK6H543 |
| 0.58% | RNA | AVIDITY BIOSCIENCES INC | -- | $513,180.70 | 7,055 | BMWHPY1 |
| 0.57% | ONC | BEONE MEDICINES LTD-ADR | -- | $508,530.00 | 1,474 | BYYWPW6 |
| 0.55% | SMMT | SUMMIT THERAPEUTICS INC | -- | $490,075.36 | 34,856 | BMTVQS7 |
| 0.53% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $475,940.05 | 2,845 | B4Q5ZN4 |
| 0.53% | TEM | TEMPUS AI INC | -- | $473,903.70 | 8,094 | BSLSJJ0 |
| 0.52% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $464,207.00 | 6,359 | BYQBFJ8 |
| 0.49% | AXSM | AXSOME THERAPEUTICS INC | -- | $438,676.80 | 2,360 | BYZR4X4 |
| 0.46% | HALO | HALOZYME THERAPEUTICS INC | -- | $409,921.70 | 5,506 | 2975098 |
| 0.43% | KRYS | KRYSTAL BIOTECH INC | -- | $383,322.66 | 1,358 | BD6JX35 |
| 0.42% | CYTK | CYTOKINETICS INC | -- | $373,041.00 | 5,725 | BBBSBJ5 |
| 0.41% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $361,967.81 | 1,171 | BQ721R4 |
| 0.40% | NUVL | NUVALENT INC-A | -- | $354,940.90 | 3,382 | BMVBZD3 |
| 0.39% | PCVX | VAXCYTE INC | -- | $351,804.60 | 6,129 | BKPVGH6 |
| 0.38% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $340,593.75 | 3,125 | BF2YWG4 |
| 0.35% | CAI | CARIS LIFE SCIENCES INC | -- | $308,080.52 | 13,211 | BT18HP9 |
| 0.35% | ABVX | ABIVAX SA-ADR | -- | $308,075.44 | 2,764 | BLC89B2 |
| 0.32% | IBRX | IMMUNITYBIO INC | -- | $282,703.34 | 46,118 | BNSP0B8 |
| 0.32% | PTCT | PTC THERAPEUTICS INC | -- | $281,473.92 | 3,759 | B17VCN9 |
| 0.32% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $281,109.36 | 3,129 | BQS9486 |
| 0.31% | COGT | COGENT BIOSCIENCES INC | -- | $272,818.52 | 7,187 | BLR6XK8 |
| 0.30% | ALKS | ALKERMES PLC | -- | $270,275.76 | 7,731 | B3P6D26 |
| 0.29% | KYMR | KYMERA THERAPEUTICS INC | -- | $254,763.78 | 3,369 | BMPRZV5 |
| 0.28% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $249,742.80 | 2,406 | BJDX8Y8 |
| 0.27% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $243,087.35 | 2,927 | BDCBCD8 |
| 0.26% | CRSP | CRISPR THERAPEUTICS AG | -- | $228,945.22 | 4,462 | BDHF4K6 |
| 0.25% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $222,609.36 | 4,776 | BFZQ0L8 |
| 0.25% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $219,262.05 | 4,443 | BDD19F8 |
| 0.24% | IMVT | IMMUNOVANT INC | -- | $214,038.56 | 8,207 | BJRFSB7 |
| 0.23% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $208,862.61 | 14,719 | BFNF1D6 |
| 0.23% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $206,975.73 | 7,921 | 2713317 |
| 0.23% | FOLD | AMICUS THERAPEUTICS INC | -- | $206,433.34 | 14,446 | B19FQ48 |
| 0.23% | CGON | CG ONCOLOGY INC | -- | $205,242.18 | 3,777 | BRBCSP4 |
| 0.23% | -- | INDIVIOR PHARMACEUTICALS INC COMMON STOCK USD 0.001 | -- | $204,540.00 | 5,844 | -- |
| 0.22% | ADMA | ADMA BIOLOGICS INC | -- | $195,020.00 | 11,144 | B9NSBM2 |
| 0.21% | GRAL | GRAIL INC | -- | $189,197.75 | 1,825 | BSLSSX7 |
| 0.21% | ACLX | ARCELLX INC | -- | $188,055.29 | 2,707 | BPCJ1Q2 |
| 0.20% | LGND | LIGAND PHARMACEUTICALS | -- | $182,491.46 | 922 | 2501578 |
| 0.19% | APGE | APOGEE THERAPEUTICS INC | -- | $168,472.21 | 2,567 | BM9HHL5 |
| 0.19% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $167,605.13 | 5,309 | BP8JSP4 |
| 0.17% | DNLI | DENALI THERAPEUTICS INC | -- | $156,155.58 | 6,867 | BD2B4V0 |
| 0.17% | TERN | TERNS PHARMACEUTICALS INC | -- | $155,306.76 | 4,218 | BMDJ0C9 |
| 0.17% | XENE | XENON PHARMACEUTICALS INC | -- | $149,966.10 | 3,618 | BRJ3GY4 |
| 0.16% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $146,643.95 | 5,735 | BKX9VD3 |
| 0.16% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $143,207.73 | 4,957 | BKY5JZ8 |
| 0.16% | IRON | DISC MEDICINE INC | -- | $142,589.20 | 1,768 | BMGJZJ8 |
| 0.16% | VCYT | VERACYTE INC | -- | $141,230.16 | 3,701 | BFTWZY0 |
| 0.16% | ERAS | ERASCA INC | -- | $140,943.24 | 13,284 | BNLYBF3 |
| 0.16% | IDYA | IDEAYA BIOSCIENCES INC | -- | $139,816.30 | 4,105 | BK0VHF6 |
| 0.16% | TVTX | TRAVERE THERAPEUTICS INC | -- | $138,634.96 | 4,189 | BLFGJD5 |
| 0.15% | VERA | VERA THERAPEUTICS INC | -- | $135,432.48 | 2,991 | BL55460 |
| 0.15% | APLS | APELLIS PHARMACEUTICALS INC | -- | $135,176.43 | 5,921 | BYTQ6X1 |
| 0.15% | TWST | TWIST BIOSCIENCE CORP | -- | $134,017.03 | 2,863 | BGKG6G7 |
| 0.15% | BEAM | BEAM THERAPEUTICS INC | -- | $132,647.92 | 4,751 | BK6L288 |
| 0.15% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $131,451.72 | 7,148 | BJ5FZ74 |
| 0.15% | TARS | TARSUS PHARMACEUTICALS INC | -- | $131,068.84 | 1,988 | BMH5RL1 |
| 0.15% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $130,974.30 | 2,685 | B72ZBG4 |
| 0.14% | DYN | DYNE THERAPEUTICS INC | -- | $125,448.12 | 6,687 | BN15WD1 |
| 0.13% | ALMS | ALUMIS INC | -- | $120,263.84 | 4,552 | BPLQG36 |
| 0.13% | SYRE | SPYRE THERAPEUTICS INC | -- | $118,980.75 | 3,633 | BQBBDY8 |
| 0.13% | MLYS | MINERALYS THERAPEUTICS INC | -- | $114,373.35 | 3,705 | BP9N0G0 |
| 0.13% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $113,783.23 | 4,517 | BLB0YQ9 |
| 0.13% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $111,840.92 | 4,517 | BJ62Z18 |
| 0.12% | TXG | 10X GENOMICS INC-CLASS A | -- | $108,807.30 | 5,454 | BKS3RS7 |
| 0.12% | WVE | WAVE LIFE SCIENCES LTD | -- | $105,170.33 | 7,831 | BYZG9R0 |
| 0.12% | MAZE | MAZE THERAPEUTICS INC | -- | $104,832.09 | 2,253 | BSRK699 |
| 0.11% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $102,054.48 | 2,697 | BKSGZN7 |
| 0.11% | SRPT | SAREPTA THERAPEUTICS INC | -- | $101,652.32 | 4,906 | B8DPDT7 |
| 0.11% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $100,633.50 | 24,075 | BM9FJ13 |
| 0.11% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $94,477.05 | 2,115 | BRXB0C0 |
| 0.11% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $94,468.95 | 3,683 | BMZ4LN0 |
| 0.11% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $93,953.06 | 6,173 | BFWLC09 |
| 0.10% | OCUL | OCULAR THERAPEUTIX INC | -- | $91,271.25 | 9,975 | BNZB1X8 |
| 0.10% | SION | SIONNA THERAPEUTICS INC | -- | $91,228.50 | 2,090 | BQKXDX4 |
| 0.10% | GMAB | GENMAB A/S -SP ADR | -- | $91,059.99 | 2,737 | BBC9WC7 |
| 0.10% | ARDX | ARDELYX INC | -- | $88,626.83 | 11,377 | BN89V40 |
| 0.10% | VCEL | VERICEL CORP | -- | $87,473.92 | 2,368 | BSBMN89 |
| 0.10% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $86,894.50 | 4,070 | BN7Q7R7 |
| 0.10% | MNKD | MANNKIND CORP | -- | $86,411.78 | 14,378 | BF081J4 |
| 0.10% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $85,164.02 | 5,498 | BRJZSK0 |
| 0.09% | ANIP | ANI PHARMACEUTICALS INC | -- | $84,160.00 | 1,052 | BCDWBX6 |
| 0.09% | -- | DEFINIUM THERAPEUTICS INC COMMON STOCK USD 0 | -- | $84,076.76 | 4,612 | -- |
| 0.09% | STOK | STOKE THERAPEUTICS INC | -- | $82,309.75 | 2,675 | BJQ05Z6 |
| 0.09% | PHVS | PHARVARIS NV | -- | $82,262.57 | 2,999 | BMZ2X38 |
| 0.09% | MBX | MBX BIOSCIENCES INC | -- | $82,125.14 | 2,102 | BQXJKH2 |
| 0.09% | ZYME | ZYMEWORKS INC | -- | $81,187.68 | 3,504 | BPCQZY9 |
| 0.09% | NRIX | NURIX THERAPEUTICS INC | -- | $81,109.14 | 4,746 | BMVLGP2 |
| 0.09% | PGEN | PRECIGEN INC | -- | $80,018.61 | 16,567 | BKM5C84 |
| 0.09% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $78,284.43 | 2,779 | BMFD115 |
| 0.09% | ALVO | ALVOTECH SA | -- | $77,969.92 | 14,656 | BPNTJ34 |
| 0.09% | HROW | HARROW INC | -- | $77,856.60 | 1,734 | BHNDW86 |
| 0.09% | ORKA | ORUKA THERAPEUTICS INC | -- | $77,758.10 | 2,267 | BKVF0J2 |
| 0.09% | TYRA | TYRA BIOSCIENCES INC | -- | $77,518.98 | 2,499 | BMVNDH9 |
| 0.09% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $76,876.80 | 2,730 | BCBVTX1 |
| 0.08% | UPB | UPSTREAM BIO INC | -- | $75,748.20 | 2,530 | BRCFFK6 |
| 0.08% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $75,433.14 | 5,142 | BPCK358 |
| 0.08% | TNGX | TANGO THERAPEUTICS INC | -- | $75,293.64 | 6,306 | BP2P6L0 |
| 0.08% | RAPT | RAPT THERAPEUTICS INC | -- | $74,810.96 | 1,297 | BTJZB49 |
| 0.08% | INVA | INNOVIVA INC | -- | $73,450.98 | 3,501 | BDDXF67 |
| 0.08% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $73,367.06 | 3,497 | BYP80F1 |
| 0.08% | FTRE | FORTREA HOLDINGS INC | -- | $72,936.36 | 4,326 | BRXYZ57 |
| 0.08% | QURE | UNIQURE NV | -- | $72,049.90 | 2,917 | BJFSR88 |
| 0.08% | NTLA | INTELLIA THERAPEUTICS INC | -- | $70,824.38 | 5,423 | BYZM6C2 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $69,722.80 | 1,480 | BX7RSN3 |
| 0.08% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $67,605.30 | 3,942 | BMX9K07 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $67,500.72 | 2,043 | BLCD809 |
| 0.07% | RLAY | RELAY THERAPEUTICS INC | -- | $66,137.25 | 8,115 | BN2R582 |
| 0.07% | NVAX | NOVAVAX INC | -- | $66,122.21 | 7,609 | BJDQXG4 |
| 0.07% | TRVI | TREVI THERAPEUTICS INC | -- | $65,803.84 | 6,004 | BJH9ZN0 |
| 0.07% | ANAB | ANAPTYSBIO INC | -- | $65,499.84 | 1,296 | BDRW1L7 |
| 0.07% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $65,358.54 | 9,858 | 2100362 |
| 0.07% | ATAI | ATAIBECKLEY INC | -- | $65,299.20 | 17,005 | BWJDYK1 |
| 0.07% | NVCR | NOVOCURE LTD | -- | $63,912.17 | 5,243 | BYSS4X4 |
| 0.07% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $63,663.12 | 3,049 | BP7KZP7 |
| 0.07% | RAPP | RAPPORT THERAPEUTICS INC | -- | $61,938.00 | 2,232 | BR3T9B6 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $60,083.84 | 2,152 | BNFWZS4 |
| 0.07% | KOD | KODIAK SCIENCES INC | -- | $59,889.24 | 2,484 | BFXC933 |
| 0.07% | TSHA | TAYSHA GENE THERAPIES INC | -- | $59,764.50 | 12,825 | BNC1BX1 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $57,246.48 | 12,472 | BMFJJ97 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $57,179.84 | 7,769 | BLR7H87 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $55,998.63 | 681 | BNSP8K3 |
| 0.06% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $55,280.50 | 4,807 | BLB0YH0 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $53,955.49 | 1,367 | BKLCWZ3 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $53,692.80 | 5,712 | B8K7T65 |
| 0.06% | SVRA | SAVARA INC | -- | $52,589.04 | 9,527 | BYXGN81 |
| 0.06% | SEPN | SEPTERNA INC | -- | $52,462.88 | 2,096 | BQNKXX2 |
| 0.06% | EYPT | EYEPOINT INC | -- | $51,512.04 | 3,876 | BMGS7L1 |
| 0.06% | ORIC | ORIC PHARMACEUTICALS INC | -- | $50,889.60 | 4,560 | BKVDFF7 |
| 0.06% | VIR | VIR BIOTECHNOLOGY INC | -- | $50,222.94 | 6,514 | BK4PZ38 |
| 0.05% | ABCL | ABCELLERA BIOLOGICS INC | -- | $49,052.50 | 14,015 | BL53SR3 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $48,512.07 | 18,587 | BF0DMK7 |
| 0.05% | CTMX | CYTOMX THERAPEUTICS INC | -- | $48,311.97 | 7,933 | BYWVTY5 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $47,668.40 | 4,628 | BMCR7V2 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $47,056.59 | 2,373 | BMNDK09 |
| 0.05% | VTYX | VENTYX BIOSCIENCES INC | -- | $46,640.36 | 3,341 | BMG99Y1 |
| 0.05% | GERN | GERON CORP | -- | $46,029.06 | 29,889 | 2370381 |
| 0.05% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $46,001.11 | 3,331 | BJLKVS6 |
| 0.05% | GHRS | GH RESEARCH PLC | -- | $45,941.28 | 2,904 | BP6C0S2 |
| 0.05% | ZBIO | ZENAS BIOPHARMA INC | -- | $45,610.95 | 2,513 | BQB42H3 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $43,821.11 | 1,933 | BMGTLY5 |
| 0.05% | ANNX | ANNEXON INC | -- | $43,237.26 | 6,777 | BMVV9R5 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $43,182.40 | 2,192 | BZ7PJQ1 |
| 0.05% | BCAX | BICARA THERAPEUTICS INC | -- | $42,989.40 | 2,565 | BQB42F1 |
| 0.05% | PCRX | PACIRA BIOSCIENCES INC | -- | $42,737.08 | 2,014 | B3X26D8 |
| 0.05% | ARVN | ARVINAS INC | -- | $41,586.81 | 3,007 | BDZ30Q0 |
| 0.05% | XNCR | XENCOR INC | -- | $40,495.84 | 3,344 | BGCYWN8 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $40,191.69 | 959 | BL95N25 |
| 0.04% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $39,531.95 | 9,005 | BZ0QMB7 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $39,468.24 | 2,296 | BQS7491 |
| 0.04% | JANX | JANUX THERAPEUTICS INC | -- | $39,395.84 | 2,816 | BMFX8Y7 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $39,175.50 | 11,193 | BBNBTD2 |
| 0.04% | OMER | OMEROS CORP | -- | $38,910.40 | 3,320 | B4NB858 |
| 0.04% | PSNL | PERSONALIS INC | -- | $38,877.30 | 4,158 | BJQ0608 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $38,132.37 | 2,367 | BD06CS0 |
| 0.04% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $37,627.98 | 7,617 | B3MZ6K5 |
| 0.04% | CGEM | CULLINAN THERAPEUTICS INC | -- | $35,155.86 | 2,766 | BM90J52 |
| 0.04% | BIOA | BIOAGE LABS INC | -- | $33,747.90 | 1,679 | BT9K6D8 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $33,691.98 | 4,074 | BYZD465 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $32,117.60 | 8,452 | BPBJFM7 |
| 0.03% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $30,608.50 | 850 | BQD3J33 |
| 0.03% | CRMD | CORMEDIX INC | -- | $30,139.13 | 3,689 | BJ0LT31 |
| 0.03% | ZLAB | ZAI LAB LTD-ADR | -- | $29,877.90 | 1,833 | BD9GVY0 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $29,511.27 | 3,769 | BFYQFJ2 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $29,163.32 | 4,412 | BMC3HS7 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $29,120.16 | 14,136 | B4N8MH9 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $27,763.47 | 2,667 | BMFK3H6 |
| 0.03% | FULC | FULCRUM THERAPEUTICS INC | -- | $27,164.48 | 2,534 | BJDX8Z9 |
| 0.03% | ALT | ALTIMMUNE INC | -- | $27,117.30 | 4,886 | BFY7DC4 |
| 0.03% | GOSS | GOSSAMER BIO INC | -- | $26,875.76 | 10,837 | BJ0CK86 |
| 0.03% | KROS | KEROS THERAPEUTICS INC | -- | $26,238.40 | 1,426 | BM7V485 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $26,105.88 | 3,417 | BQ6C357 |
| 0.03% | REPL | REPLIMUNE GROUP INC | -- | $25,619.18 | 3,673 | BDDVW37 |
| 0.03% | RGNX | REGENXBIO INC | -- | $25,548.60 | 2,370 | BZ0G875 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $24,672.96 | 2,636 | BLFBZ32 |
| 0.03% | LYEL | LYELL IMMUNOPHARMA INC | -- | $24,596.61 | 993 | BTNMG41 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $24,476.25 | 2,675 | BKLXFX5 |
| 0.03% | LENZ | LENZ THERAPEUTICS INC | -- | $23,879.50 | 1,465 | BQV0J03 |
| 0.03% | SLDB | SOLID BIOSCIENCES INC | -- | $23,456.64 | 3,648 | BQHN6C7 |
| 0.03% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $23,419.20 | 5,712 | BYVQJ96 |
| 0.03% | SIGA | SIGA TECHNOLOGIES INC | -- | $23,303.35 | 3,353 | 2107437 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $23,173.71 | 677 | B292NQ7 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $22,882.30 | 6,790 | BMCWKZ2 |
| 0.03% | IVVD | INVIVYD INC | -- | $22,576.50 | 12,975 | BM8NHS1 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $22,453.20 | 2,520 | B91XRN2 |
| 0.02% | KMDA | KAMADA LTD | -- | $22,256.24 | 2,701 | B2Q9833 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $21,416.58 | 2,767 | B12W3P6 |
| 0.02% | ABSI | ABSCI CORP | -- | $21,263.82 | 7,041 | BN94K69 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $21,211.50 | 1,790 | BP81RK8 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $19,727.52 | 876 | BPBPCG8 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $19,676.14 | 10,522 | BFZNYB7 |
| 0.02% | ETON | ETON PHARMACEUTICALS INC | -- | $19,053.52 | 1,256 | BGL0JK3 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $18,907.16 | 4,183 | BYTYP72 |
| 0.02% | ACRS | ACLARIS THERAPEUTICS INC | -- | $18,313.53 | 5,073 | BYV2W40 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $17,819.69 | 1,351 | B9L5200 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $17,608.80 | 5,060 | BDFKQ07 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $17,481.24 | 2,973 | BP81R42 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $17,084.83 | 2,051 | BSMLR16 |
| 0.02% | NBP | NOVABRIDGE BIOSCIENCES | -- | $16,697.24 | 4,868 | BKRRKY7 |
| 0.02% | PEPG | PEPGEN INC | -- | $16,352.52 | 3,219 | BMTX3D7 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $16,088.38 | 2,359 | B7F2TY6 |
| 0.02% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $15,559.16 | 1,082 | BPRBTY7 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $15,490.80 | 2,648 | BMF7DT9 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $15,489.54 | 7,823 | BN4JN37 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $15,372.27 | 4,701 | BZC0D70 |
| 0.02% | CADL | CANDEL THERAPEUTICS INC | -- | $15,085.90 | 2,570 | BP0TQC5 |
| 0.02% | LFCR | LIFECORE BIOMEDICAL INC | -- | $14,944.08 | 1,754 | 2517058 |
| 0.02% | EOLS | EVOLUS INC | -- | $14,901.85 | 3,035 | BDRJH21 |
| 0.02% | AVIR | ATEA PHARMACEUTICALS INC | -- | $14,888.06 | 3,658 | BLN9Z50 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $14,570.86 | 3,023 | BMVBZF5 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $14,068.08 | 4,008 | BMXNGZ6 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $14,057.34 | 2,166 | BKDQKM6 |
| 0.02% | AARD | AARDVARK THERAPEUTICS INC | -- | $13,552.70 | 1,019 | BTXQTX3 |
| 0.01% | NGNE | NEUROGENE INC | -- | $13,289.25 | 725 | BS2F741 |
| 0.01% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $12,960.96 | 9,392 | BFMLGR4 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $12,280.03 | 5,659 | BRK0149 |
| 0.01% | OABI | OMNIAB INC | -- | $12,064.60 | 6,740 | BN13S71 |
| 0.01% | CABA | CABALETTA BIO INC | -- | $11,267.50 | 4,507 | BK5MWR1 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $11,036.00 | 2,759 | BY7RB53 |
| 0.01% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $10,775.10 | 2,199 | BL5B6Z1 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $10,628.88 | 2,644 | BPRB2N7 |
| 0.01% | VOR | VOR BIOPHARMA INC | -- | $10,091.31 | 789 | BRJJYT3 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $10,071.60 | 9,156 | BNR5QT9 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $9,802.10 | 1,330 | BKC9SX3 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $9,187.71 | 4,571 | BZ8FPH3 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $9,045.96 | 1,452 | BP2NYN2 |
| 0.01% | HUMA | HUMACYTE INC | -- | $8,943.36 | 8,768 | BMYTJP4 |
| 0.01% | MENS | JYONG BIOTECH LTD | -- | $8,544.00 | 3,560 | BPTK6Z2 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $8,531.44 | 4,538 | BKX9NQ0 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $7,030.43 | 7,796 | BNNXX52 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $6,776.72 | 2,668 | BKTV702 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $6,388.96 | 4,376 | BNYJR68 |
| 0.01% | CDXS | CODEXIS INC | -- | $6,089.76 | 4,229 | B5LL2C2 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $5,939.22 | 2,506 | BP7L561 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $5,480.40 | 4,567 | BNNXX18 |
| -- | PYXS | PYXIS ONCOLOGY INC | -- | $4,459.95 | 2,915 | BLBR8D5 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $15.10 | 01 | BTFHQP5 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 39.25% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 35,024,972 | -- | 5,919 | -- |
| 29.28% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 26,125,233 | -- | 4,415 | -- |
| 23.49% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 20,965,277 | -- | 3,543 | -- |
| 17.50% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 15,615,966 | -- | 2,639 | -- |
| 16.47% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,698,772 | -- | 2,484 | -- |
| 4.20% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,745,702 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $27,191,704.78 | 27,191,705 | -- |
Index
as of 12/31/2025
- Total Number of Companies262
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$7.32 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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