BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 2/28/2026
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 6.03% | 5.70% | 60.37% | 10.56% | 62.26% | 19.25% | -0.31% | 8.72% | 16.98% | 04/07/2010 |
| BIB Market Price | 6.05% | 5.51% | 60.28% | 10.49% | 62.05% | 19.26% | -0.28% | 8.72% | 16.98% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 3/16/2026- NAV $80.24
- NAV Change $+1.60
- Market Price $80.20
- Market Price Change $+1.57
- Trading Volume (M) 5,839
- 30-Day Median Bid Ask Spread 0.24%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 3/16/2026- NAV $80.24
- NAV Change $+1.60
- Market Price $80.20
- Market Price Change $+1.57
- Trading Volume (M) 5,839
- 30-Day Median Bid Ask Spread 0.24%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 12/31/2025
Holdings
as of 3/16/2026
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 6.85% | GILD | GILEAD SCIENCES INC | -- | $5,553,556.45 | 38,245 | 2369174 |
| 6.38% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,172,777.80 | 11,098 | 2931034 |
| 6.30% | AMGN | AMGEN INC | -- | $5,102,961.25 | 13,933 | 2023607 |
| 4.27% | REGN | REGENERON PHARMACEUTICALS | -- | $3,459,835.61 | 4,571 | 2730190 |
| 2.30% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $1,864,347.86 | 5,846 | B00FWN1 |
| 1.68% | INSM | INSMED INC | -- | $1,364,590.20 | 9,437 | 2614487 |
| 1.47% | BIIB | BIOGEN INC | -- | $1,189,723.92 | 6,492 | 2455965 |
| 1.26% | UTHR | UNITED THERAPEUTICS CORP | -- | $1,017,307.20 | 1,904 | 2430412 |
| 1.14% | MRNA | MODERNA INC | -- | $921,676.59 | 17,289 | BGSXTS3 |
| 1.12% | ARGX | ARGENX SE - ADR | -- | $905,147.10 | 1,287 | BDVLM39 |
| 1.08% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $871,751.00 | 18,910 | BMVP7Y0 |
| 1.07% | ROIV | ROIVANT SCIENCES LTD | -- | $870,430.12 | 30,779 | BMW4NZ9 |
| 1.05% | RVMD | REVOLUTION MEDICINES INC | -- | $846,945.00 | 8,555 | BL71K91 |
| 1.00% | INCY | INCYTE CORP | -- | $807,891.00 | 8,687 | 2471950 |
| 1.00% | ILMN | ILLUMINA INC | -- | $806,452.08 | 6,761 | 2613990 |
| 0.85% | VTRS | VIATRIS INC | -- | $688,631.72 | 50,972 | BMWS3X9 |
| 0.77% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $627,925.95 | 2,718 | BV9G6B8 |
| 0.75% | BBIO | BRIDGEBIO PHARMA INC | -- | $605,743.84 | 8,528 | BK1KWG8 |
| 0.71% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $572,898.20 | 4,412 | 2623911 |
| 0.70% | MEDP | MEDPACE HOLDINGS INC | -- | $565,689.08 | 1,247 | BDCBC61 |
| 0.66% | SMMT | SUMMIT THERAPEUTICS INC | -- | $532,917.73 | 32,947 | BMTVQS7 |
| 0.64% | IONS | IONIS PHARMACEUTICALS INC | -- | $518,460.78 | 7,167 | BDJ0LS6 |
| 0.64% | SNY | SANOFI-ADR | -- | $515,093.76 | 11,712 | 2964557 |
| 0.62% | GH | GUARDANT HEALTH INC | -- | $499,105.50 | 5,725 | BFXC911 |
| 0.60% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $489,451.78 | 2,689 | B4Q5ZN4 |
| 0.60% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $488,269.86 | 8,502 | 2437071 |
| 0.60% | EXEL | EXELIXIS INC | -- | $487,295.55 | 11,865 | 2576941 |
| 0.55% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $442,152.49 | 1,003 | BD59BS7 |
| 0.50% | BNTX | BIONTECH SE-ADR | -- | $405,075.96 | 4,474 | BK6H543 |
| 0.50% | ONC | BEONE MEDICINES LTD-ADR | -- | $403,772.10 | 1,394 | BYYWPW6 |
| 0.48% | TEM | TEMPUS AI INC-CL A | -- | $389,181.12 | 7,649 | BSLSJJ0 |
| 0.44% | IBRX | IMMUNITYBIO INC | -- | $357,882.11 | 43,591 | BNSP0B8 |
| 0.44% | AXSM | AXSOME THERAPEUTICS INC | -- | $353,011.13 | 2,231 | BYZR4X4 |
| 0.43% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $344,793.70 | 6,010 | BYQBFJ8 |
| 0.42% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $337,635.00 | 1,107 | BQ721R4 |
| 0.41% | HALO | HALOZYME THERAPEUTICS INC | -- | $334,629.45 | 5,205 | 2975098 |
| 0.41% | CYTK | CYTOKINETICS INC | -- | $329,211.96 | 5,412 | BBBSBJ5 |
| 0.40% | PCVX | VAXCYTE INC | -- | $322,151.04 | 5,792 | BKPVGH6 |
| 0.40% | KRYS | KRYSTAL BIOTECH INC | -- | $320,705.12 | 1,282 | BD6JX35 |
| 0.40% | ABVX | ABIVAX SA-ADR | -- | $320,623.00 | 2,612 | BLC89B2 |
| 0.39% | NUVL | NUVALENT INC-A | -- | $318,181.43 | 3,197 | BMVBZD3 |
| 0.36% | ACLX | ARCELLX INC | -- | $293,031.09 | 2,559 | BPCJ1Q2 |
| 0.33% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $267,707.25 | 2,767 | BDCBCD8 |
| 0.33% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $267,276.03 | 2,953 | BF2YWG4 |
| 0.31% | KYMR | KYMERA THERAPEUTICS INC | -- | $253,446.40 | 3,184 | BMPRZV5 |
| 0.30% | COGT | COGENT BIOSCIENCES INC | -- | $242,409.92 | 6,794 | BLR6XK8 |
| 0.29% | CAI | CARIS LIFE SCIENCES INC | -- | $237,858.30 | 12,486 | BT18HP9 |
| 0.29% | PTCT | PTC THERAPEUTICS INC | -- | $237,087.34 | 3,554 | B17VCN9 |
| 0.29% | CGON | CG ONCOLOGY INC | -- | $235,197.10 | 3,569 | BRBCSP4 |
| 0.26% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $210,663.36 | 2,274 | BJDX8Y8 |
| 0.25% | ALKS | ALKERMES PLC | -- | $204,568.00 | 7,306 | B3P6D26 |
| 0.25% | CRSP | CRISPR THERAPEUTICS AG | -- | $204,187.14 | 4,217 | BDHF4K6 |
| 0.24% | FOLD | AMICUS THERAPEUTICS INC | -- | $196,236.72 | 13,656 | B19FQ48 |
| 0.24% | IMVT | IMMUNOVANT INC | -- | $193,950.00 | 7,758 | BJRFSB7 |
| 0.23% | XENE | XENON PHARMACEUTICALS INC | -- | $186,991.86 | 3,421 | BRJ3GY4 |
| 0.23% | TERN | TERNS PHARMACEUTICALS INC | -- | $183,635.02 | 3,986 | BMDJ0C9 |
| 0.22% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $181,773.90 | 4,515 | BFZQ0L8 |
| 0.22% | LGND | LIGAND PHARMACEUTICALS | -- | $180,786.00 | 870 | 2501578 |
| 0.21% | APGE | APOGEE THERAPEUTICS INC | -- | $172,535.43 | 2,427 | BM9HHL5 |
| 0.21% | INDV | INDIVIOR PHARMACEUTICALS INC | -- | $171,047.31 | 5,523 | BTZRLN8 |
| 0.21% | ERAS | ERASCA INC | -- | $169,618.05 | 12,555 | BNLYBF3 |
| 0.21% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $167,514.05 | 2,957 | BQS9486 |
| 0.21% | ADMA | ADMA BIOLOGICS INC | -- | $166,858.56 | 10,534 | B9NSBM2 |
| 0.20% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $166,121.22 | 13,913 | BFNF1D6 |
| 0.20% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $160,168.32 | 7,488 | 2713317 |
| 0.19% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $156,538.72 | 4,199 | BDD19F8 |
| 0.19% | SYRE | SPYRE THERAPEUTICS INC | -- | $151,292.31 | 3,433 | BQBBDY8 |
| 0.18% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $149,456.43 | 5,017 | BP8JSP4 |
| 0.17% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $139,519.30 | 4,685 | BKY5JZ8 |
| 0.17% | IDYA | IDEAYA BIOSCIENCES INC | -- | $134,985.20 | 3,880 | BK0VHF6 |
| 0.16% | DNLI | DENALI THERAPEUTICS INC | -- | $133,499.30 | 6,490 | BD2B4V0 |
| 0.16% | TARS | TARSUS PHARMACEUTICALS INC | -- | $129,532.00 | 1,880 | BMH5RL1 |
| 0.16% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $127,382.77 | 2,537 | B72ZBG4 |
| 0.15% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $123,404.72 | 5,422 | BKX9VD3 |
| 0.15% | TWST | TWIST BIOSCIENCE CORP | -- | $121,797.06 | 2,706 | BGKG6G7 |
| 0.15% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $120,770.01 | 4,269 | BLB0YQ9 |
| 0.14% | VCYT | VERACYTE INC | -- | $115,121.24 | 3,497 | BFTWZY0 |
| 0.14% | DYN | DYNE THERAPEUTICS INC | -- | $114,617.86 | 6,322 | BN15WD1 |
| 0.14% | BEAM | BEAM THERAPEUTICS INC | -- | $114,450.10 | 4,490 | BK6L288 |
| 0.14% | VERA | VERA THERAPEUTICS INC | -- | $113,221.35 | 2,827 | BL55460 |
| 0.14% | ALMS | ALUMIS INC | -- | $112,738.60 | 4,303 | BPLQG36 |
| 0.14% | TVTX | TRAVERE THERAPEUTICS INC | -- | $110,998.80 | 3,960 | BLFGJD5 |
| 0.13% | MAZE | MAZE THERAPEUTICS INC | -- | $109,132.54 | 2,129 | BSRK699 |
| 0.13% | TNGX | TANGO THERAPEUTICS INC | -- | $106,582.68 | 5,961 | BP2P6L0 |
| 0.13% | APLS | APELLIS PHARMACEUTICALS INC | -- | $105,596.52 | 5,596 | BYTQ6X1 |
| 0.13% | IRON | DISC MEDICINE INC | -- | $101,808.08 | 1,672 | BMGJZJ8 |
| 0.12% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $97,038.48 | 4,543 | BLB0YH0 |
| 0.11% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $93,149.58 | 4,269 | BJ62Z18 |
| 0.11% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $92,953.50 | 1,999 | BRXB0C0 |
| 0.11% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $92,457.84 | 3,846 | BN7Q7R7 |
| 0.11% | WVE | WAVE LIFE SCIENCES LTD | -- | $91,858.82 | 7,402 | BYZG9R0 |
| 0.11% | MLYS | MINERALYS THERAPEUTICS INC | -- | $90,080.73 | 3,501 | BP9N0G0 |
| 0.11% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $89,976.60 | 6,755 | BJ5FZ74 |
| 0.11% | ORKA | ORUKA THERAPEUTICS INC | -- | $89,470.25 | 2,143 | BKVF0J2 |
| 0.11% | TYRA | TYRA BIOSCIENCES INC | -- | $87,417.62 | 2,362 | BMVNDH9 |
| 0.11% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $86,648.10 | 9,317 | 2100362 |
| 0.11% | TXG | 10X GENOMICS INC-CLASS A | -- | $86,020.26 | 5,154 | BKS3RS7 |
| 0.11% | STOK | STOKE THERAPEUTICS INC | -- | $85,816.92 | 2,527 | BJQ05Z6 |
| 0.10% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $83,513.16 | 5,836 | BFWLC09 |
| 0.10% | OCUL | OCULAR THERAPEUTIX INC | -- | $81,372.27 | 9,429 | BNZB1X8 |
| 0.10% | DFTX | DEFINIUM THERAPEUTICS INC | -- | $79,856.88 | 4,359 | BV2DHY6 |
| 0.10% | ANAB | ANAPTYSBIO INC | -- | $79,290.72 | 1,224 | BDRW1L7 |
| 0.10% | GRAL | GRAIL INC | -- | $78,918.75 | 1,725 | BSLSSX7 |
| 0.10% | ZYME | ZYMEWORKS INC | -- | $78,229.44 | 3,312 | BPCQZY9 |
| 0.10% | RLAY | RELAY THERAPEUTICS INC | -- | $77,697.10 | 7,670 | BN2R582 |
| 0.10% | SRPT | SAREPTA THERAPEUTICS INC | -- | $77,252.42 | 4,637 | B8DPDT7 |
| 0.10% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $77,142.84 | 22,756 | BM9FJ13 |
| 0.09% | PHVS | PHARVARIS NV | -- | $76,346.55 | 2,835 | BMZ2X38 |
| 0.09% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $74,436.04 | 2,581 | BCBVTX1 |
| 0.09% | SION | SIONNA THERAPEUTICS INC | -- | $73,373.58 | 1,974 | BQKXDX4 |
| 0.09% | INVA | INNOVIVA INC | -- | $73,294.35 | 3,309 | BDDXF67 |
| 0.09% | NVAX | NOVAVAX INC | -- | $72,495.36 | 7,192 | BJDQXG4 |
| 0.09% | VCEL | VERICEL CORP | -- | $72,297.31 | 2,239 | BSBMN89 |
| 0.09% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $71,953.53 | 2,627 | BMFD115 |
| 0.09% | ANIP | ANI PHARMACEUTICALS INC | -- | $71,809.15 | 995 | BCDWBX6 |
| 0.09% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $71,166.60 | 3,726 | BMX9K07 |
| 0.09% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $71,015.14 | 2,549 | BKSGZN7 |
| 0.09% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $70,974.72 | 17,568 | BF0DMK7 |
| 0.09% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $69,901.18 | 4,861 | BPCK358 |
| 0.09% | NRIX | NURIX THERAPEUTICS INC | -- | $68,979.30 | 4,485 | BMVLGP2 |
| 0.08% | GMAB | GENMAB A/S -SP ADR | -- | $68,737.28 | 2,588 | BBC9WC7 |
| 0.08% | NTLA | INTELLIA THERAPEUTICS INC | -- | $68,585.88 | 5,126 | BYZM6C2 |
| 0.08% | TRVI | TREVI THERAPEUTICS INC | -- | $63,333.00 | 5,675 | BJH9ZN0 |
| 0.08% | ARDX | ARDELYX INC | -- | $62,791.68 | 10,752 | BN89V40 |
| 0.08% | NVCR | NOVOCURE LTD | -- | $61,342.90 | 4,955 | BYSS4X4 |
| 0.07% | VIR | VIR BIOTECHNOLOGY INC | -- | $59,568.98 | 6,157 | BK4PZ38 |
| 0.07% | MBX | MBX BIOSCIENCES INC | -- | $59,182.80 | 1,986 | BQXJKH2 |
| 0.07% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $59,030.67 | 1,931 | BLCD809 |
| 0.07% | ATAI | ATAIBECKLEY INC | -- | $58,670.10 | 16,074 | BWJDYK1 |
| 0.07% | RAPP | RAPPORT THERAPEUTICS INC | -- | $58,222.96 | 2,108 | BR3T9B6 |
| 0.07% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $57,801.20 | 3,482 | BMZ4LN0 |
| 0.07% | HROW | HARROW INC | -- | $57,182.58 | 1,638 | BHNDW86 |
| 0.07% | ZBIO | ZENAS BIOPHARMA INC | -- | $55,194.48 | 2,376 | BQB42H3 |
| 0.07% | PGEN | PRECIGEN INC | -- | $54,966.60 | 15,660 | BKM5C84 |
| 0.07% | TSHA | TAYSHA GENE THERAPIES INC | -- | $54,917.19 | 12,123 | BNC1BX1 |
| 0.07% | KOD | KODIAK SCIENCES INC | -- | $54,731.88 | 2,348 | BFXC933 |
| 0.07% | ORIC | ORIC PHARMACEUTICALS INC | -- | $52,680.42 | 4,311 | BKVDFF7 |
| 0.06% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $51,954.60 | 3,305 | BYP80F1 |
| 0.06% | CTMX | CYTOMX THERAPEUTICS INC | -- | $50,618.25 | 7,499 | BYWVTY5 |
| 0.06% | ALVO | ALVOTECH SA | -- | $50,012.94 | 13,854 | BPNTJ34 |
| 0.06% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $49,868.00 | 1,400 | BX7RSN3 |
| 0.06% | SEPN | SEPTERNA INC | -- | $49,777.20 | 1,980 | BQNKXX2 |
| 0.06% | EYPT | EYEPOINT INC | -- | $49,267.35 | 3,663 | BMGS7L1 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $47,155.76 | 13,246 | BL53SR3 |
| 0.06% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $47,104.35 | 2,881 | BP7KZP7 |
| 0.06% | SVRA | SAVARA INC | -- | $47,096.15 | 9,005 | BYXGN81 |
| 0.06% | BCAX | BICARA THERAPEUTICS INC | -- | $47,045.00 | 2,425 | BQB42F1 |
| 0.06% | GERN | GERON CORP | -- | $46,610.85 | 28,249 | 2370381 |
| 0.06% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $46,411.19 | 907 | BL95N25 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $44,672.70 | 645 | BNSP8K3 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $44,438.68 | 1,828 | BMGTLY5 |
| 0.05% | QURE | UNIQURE NV | -- | $43,946.58 | 2,757 | BJFSR88 |
| 0.05% | GRFS | GRIFOLS SA-ADR | -- | $43,461.95 | 5,399 | B8K7T65 |
| 0.05% | PCRX | PACIRA BIOSCIENCES INC | -- | $43,156.38 | 1,902 | B3X26D8 |
| 0.05% | GHRS | GH RESEARCH PLC | -- | $41,461.84 | 2,744 | BP6C0S2 |
| 0.05% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $40,318.56 | 7,344 | BLR7H87 |
| 0.05% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $39,499.35 | 2,035 | BNFWZS4 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $38,808.56 | 2,072 | BZ7PJQ1 |
| 0.05% | SANA | SANA BIOTECHNOLOGY INC | -- | $38,553.30 | 11,790 | BMFJJ97 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $38,062.50 | 4,375 | BMCR7V2 |
| 0.05% | XNCR | XENCOR INC | -- | $38,014.80 | 3,160 | BGCYWN8 |
| 0.05% | FTRE | FORTREA HOLDINGS INC | -- | $37,905.03 | 4,089 | BRXYZ57 |
| 0.05% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $37,643.16 | 2,238 | BD06CS0 |
| 0.05% | MNKD | MANNKIND CORP | -- | $37,641.53 | 13,589 | BF081J4 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $37,112.32 | 8,512 | BZ0QMB7 |
| 0.05% | JANX | JANUX THERAPEUTICS INC | -- | $36,962.44 | 2,663 | BMFX8Y7 |
| 0.05% | CGEM | CULLINAN THERAPEUTICS INC | -- | $36,674.42 | 2,614 | BM90J52 |
| 0.05% | ANNX | ANNEXON INC | -- | $36,630.88 | 6,404 | BMVV9R5 |
| 0.04% | OMER | OMEROS CORP | -- | $34,968.46 | 3,139 | B4NB858 |
| 0.04% | ARVN | ARVINAS INC | -- | $34,899.76 | 2,842 | BDZ30Q0 |
| 0.04% | BIOA | BIOAGE LABS INC | -- | $34,199.85 | 1,587 | BT9K6D8 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $33,610.50 | 3,850 | BYZD465 |
| 0.04% | CSTL | CASTLE BIOSCIENCES INC | -- | $33,346.53 | 1,291 | BKLCWZ3 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $33,030.98 | 1,733 | BD9GVY0 |
| 0.04% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $32,854.68 | 3,147 | BJLKVS6 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $31,761.73 | 2,171 | BQS7491 |
| 0.04% | TBPH | THERAVANCE BIOPHARMA INC | -- | $31,258.92 | 2,244 | BMNDK09 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $29,312.29 | 7,987 | BPBJFM7 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $28,457.51 | 10,579 | BBNBTD2 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $27,716.78 | 2,522 | BMFK3H6 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $27,384.09 | 3,561 | BFYQFJ2 |
| 0.03% | TECX | TECTONIC THERAPEUTIC INC | -- | $26,827.20 | 828 | BPBPCG8 |
| 0.03% | PSNL | PERSONALIS INC | -- | $26,684.70 | 3,930 | BJQ0608 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $26,319.01 | 4,171 | BMC3HS7 |
| 0.03% | SLDB | SOLID BIOSCIENCES INC | -- | $25,791.04 | 3,448 | BQHN6C7 |
| 0.03% | REPL | REPLIMUNE GROUP INC | -- | $25,553.92 | 3,472 | BDDVW37 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $24,596.04 | 2,492 | BLFBZ32 |
| 0.03% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $24,265.80 | 9,945 | BFZNYB7 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $24,264.00 | 7,200 | B3MZ6K5 |
| 0.03% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $23,293.21 | 4,783 | BDFKQ07 |
| 0.03% | VNDA | VANDA PHARMACEUTICALS INC | -- | $23,038.15 | 2,615 | B12W3P6 |
| 0.03% | UPB | UPSTREAM BIO INC | -- | $22,967.90 | 2,390 | BRCFFK6 |
| 0.03% | CRMD | CORMEDIX INC | -- | $22,811.52 | 3,488 | BJ0LT31 |
| 0.03% | KMDA | KAMADA LTD | -- | $22,721.70 | 2,553 | B2Q9833 |
| 0.03% | ETON | ETON PHARMACEUTICALS INC | -- | $22,583.88 | 1,188 | BGL0JK3 |
| 0.03% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $22,567.82 | 5,399 | BYVQJ96 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $21,852.11 | 2,383 | B91XRN2 |
| 0.03% | TRDA | ENTRADA THERAPEUTICS INC | -- | $21,568.82 | 1,693 | BP81RK8 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $21,428.96 | 2,527 | BKLXFX5 |
| 0.03% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $21,293.10 | 802 | BQD3J33 |
| 0.03% | NMRA | NEUMORA THERAPEUTICS INC | -- | $21,220.78 | 7,394 | BN4JN37 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $21,214.53 | 3,229 | BQ6C357 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $20,960.70 | 641 | B292NQ7 |
| 0.03% | AVIR | ATEA PHARMACEUTICALS INC | -- | $20,914.85 | 3,457 | BLN9Z50 |
| 0.03% | IVVD | INVIVYD INC | -- | $20,482.55 | 12,265 | BM8NHS1 |
| 0.02% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $20,213.55 | 6,417 | BMCWKZ2 |
| 0.02% | LYEL | LYELL IMMUNOPHARMA INC | -- | $19,798.81 | 937 | BTNMG41 |
| 0.02% | RGNX | REGENXBIO INC | -- | $19,698.39 | 2,241 | BZ0G875 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $18,932.66 | 2,809 | BP81R42 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $18,623.34 | 3,954 | BYTYP72 |
| 0.02% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $18,172.32 | 13,362 | B4N8MH9 |
| 0.02% | ACRS | ACLARIS THERAPEUTICS INC | -- | $17,937.04 | 4,796 | BYV2W40 |
| 0.02% | FULC | FULCRUM THERAPEUTICS INC | -- | $17,811.36 | 2,394 | BJDX8Z9 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $17,625.51 | 1,939 | BSMLR16 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $17,302.74 | 3,169 | 2107437 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $16,717.16 | 4,618 | BFY7DC4 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $16,667.20 | 3,788 | BMXNGZ6 |
| 0.02% | ABSI | ABSCI CORP | -- | $16,640.00 | 6,656 | BN94K69 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $16,498.98 | 1,278 | B9L5200 |
| 0.02% | PEPG | PEPGEN INC | -- | $16,280.05 | 3,043 | BMTX3D7 |
| 0.02% | LENZ | LENZ THERAPEUTICS INC | -- | $16,259.90 | 1,385 | BQV0J03 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $15,280.65 | 2,079 | BL5B6Z1 |
| 0.02% | KROS | KEROS THERAPEUTICS INC | -- | $14,879.47 | 1,349 | BM7V485 |
| 0.02% | NGNE | NEUROGENE INC | -- | $14,775.45 | 685 | BS2F741 |
| 0.02% | EOLS | EVOLUS INC | -- | $14,464.80 | 2,870 | BDRJH21 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $14,175.68 | 2,858 | BMVBZF5 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $13,909.72 | 4,444 | BZC0D70 |
| 0.02% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $13,664.14 | 1,022 | BPRBTY7 |
| 0.02% | CABA | CABALETTA BIO INC | -- | $13,628.80 | 4,259 | BK5MWR1 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $13,536.10 | 2,230 | B7F2TY6 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $13,405.78 | 8,878 | BFMLGR4 |
| 0.02% | NBP | NOVABRIDGE BIOSCIENCES | -- | $13,340.00 | 4,600 | BKRRKY7 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $12,439.91 | 2,503 | BMF7DT9 |
| 0.01% | CADL | CANDEL THERAPEUTICS INC | -- | $12,125.70 | 2,430 | BP0TQC5 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $11,708.97 | 4,289 | BKX9NQ0 |
| 0.01% | OABI | OMNIAB INC | -- | $11,658.93 | 6,371 | BN13S71 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $11,370.45 | 2,499 | BPRB2N7 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $11,262.24 | 2,607 | BY7RB53 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $10,977.88 | 4,322 | BZ8FPH3 |
| 0.01% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $10,332.30 | 2,046 | BKDQKM6 |
| 0.01% | VOR | VOR BIOPHARMA INC | -- | $10,251.20 | 745 | BRJJYT3 |
| 0.01% | HUMA | HUMACYTE INC | -- | $9,281.44 | 8,287 | BMYTJP4 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $8,881.00 | 5,350 | BRK0149 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $8,340.54 | 1,258 | BKC9SX3 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $8,165.99 | 8,655 | BNR5QT9 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $7,734.32 | 4,136 | BNYJR68 |
| 0.01% | LFCR | LIFECORE BIOMEDICAL INC | -- | $7,237.17 | 1,658 | 2517058 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $7,130.69 | 2,369 | BP7L561 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $7,052.08 | 1,372 | BP2NYN2 |
| 0.01% | MENS | JYONG BIOTECH LTD | -- | $6,660.72 | 3,364 | BPTK6Z2 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $6,314.26 | 7,367 | BNNXX52 |
| 0.01% | CDXS | CODEXIS INC | -- | $5,995.50 | 3,997 | B5LL2C2 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $5,699.76 | 4,318 | BNNXX18 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $5,525.37 | 2,523 | BKTV702 |
| 0.01% | AARD | AARDVARK THERAPEUTICS INC | -- | $5,161.68 | 963 | BTXQTX3 |
| 0.01% | GOSS | GOSSAMER BIO INC | -- | $4,670.81 | 10,243 | BJ0CK86 |
| 0.01% | PYXS | PYXIS ONCOLOGY INC | -- | $4,600.85 | 2,755 | BLBR8D5 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $23.49 | 01 | BTFHQP5 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 31.89% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 25,839,590 | -- | 4,475 | -- |
| 30.52% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 24,730,941 | -- | 4,283 | -- |
| 26.38% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 21,376,125 | -- | 3,702 | -- |
| 18.80% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 15,238,140 | -- | 2,639 | -- |
| 17.70% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,343,138 | -- | 2,484 | -- |
| 4.51% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,655,075 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $24,472,046.28 | 24,472,046 | -- |
Index
as of 12/31/2025
- Total Number of Companies262
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$7.32 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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