BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 1/31/2026
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 4.27% | 16.53% | 65.39% | 4.27% | 51.38% | 11.58% | -2.47% | 6.91% | 16.64% | 04/07/2010 |
| BIB Market Price | 4.19% | 16.41% | 65.44% | 4.19% | 51.07% | 11.50% | -2.49% | 6.94% | 16.64% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 3/02/2026- NAV $87.31
- NAV Change $-0.87
- Market Price $87.32
- Market Price Change $-0.83
- Trading Volume (M) 5,397
- 30-Day Median Bid Ask Spread 0.26%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 3/02/2026- NAV $87.31
- NAV Change $-0.87
- Market Price $87.32
- Market Price Change $-0.83
- Trading Volume (M) 5,397
- 30-Day Median Bid Ask Spread 0.26%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 12/31/2025
Holdings
as of 3/02/2026
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 6.59% | GILD | GILEAD SCIENCES INC | -- | $5,986,797.12 | 39,904 | 2369174 |
| 6.20% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,628,713.43 | 11,581 | 2931034 |
| 6.17% | AMGN | AMGEN INC | -- | $5,606,535.20 | 14,536 | 2023607 |
| 4.15% | REGN | REGENERON PHARMACEUTICALS | -- | $3,771,372.89 | 4,769 | 2730190 |
| 2.18% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $1,983,252.07 | 6,101 | B00FWN1 |
| 1.59% | INSM | INSMED INC | -- | $1,440,959.36 | 9,848 | 2614487 |
| 1.40% | BIIB | BIOGEN INC | -- | $1,273,850.70 | 6,774 | 2455965 |
| 1.12% | UTHR | UNITED THERAPEUTICS CORP | -- | $1,021,474.16 | 1,988 | 2430412 |
| 1.12% | ARGX | ARGENX SE - ADR | -- | $1,017,085.44 | 1,344 | BDVLM39 |
| 1.05% | MRNA | MODERNA INC | -- | $953,270.96 | 18,039 | BGSXTS3 |
| 1.03% | ILMN | ILLUMINA INC | -- | $937,538.95 | 7,055 | 2613990 |
| 1.03% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $936,535.63 | 19,729 | BMVP7Y0 |
| 1.00% | RVMD | REVOLUTION MEDICINES INC | -- | $907,161.74 | 8,927 | BL71K91 |
| 1.00% | INCY | INCYTE CORP | -- | $906,862.60 | 9,065 | 2471950 |
| 0.99% | ROIV | ROIVANT SCIENCES LTD | -- | $902,403.40 | 32,114 | BMW4NZ9 |
| 0.92% | VTRS | VIATRIS INC | -- | $834,973.10 | 53,183 | BMWS3X9 |
| 0.76% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $686,325.15 | 2,835 | BV9G6B8 |
| 0.68% | IONS | IONIS PHARMACEUTICALS INC | -- | $612,978.84 | 7,479 | BDJ0LS6 |
| 0.67% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $609,477.52 | 4,604 | 2623911 |
| 0.66% | MEDP | MEDPACE HOLDINGS INC | -- | $595,168.47 | 1,301 | BDCBC61 |
| 0.64% | BBIO | BRIDGEBIO PHARMA INC | -- | $582,753.50 | 8,897 | BK1KWG8 |
| 0.64% | SNY | SANOFI-ADR | -- | $582,357.54 | 12,219 | 2964557 |
| 0.61% | SMMT | SUMMIT THERAPEUTICS INC | -- | $556,531.25 | 34,375 | BMTVQS7 |
| 0.61% | GH | GUARDANT HEALTH INC | -- | $550,982.02 | 5,974 | BFXC911 |
| 0.59% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $534,430.76 | 2,806 | B4Q5ZN4 |
| 0.58% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $529,953.54 | 8,871 | 2437071 |
| 0.56% | EXEL | EXELIXIS INC | -- | $507,992.43 | 12,381 | 2576941 |
| 0.55% | BNTX | BIONTECH SE-ADR | -- | $501,824.12 | 4,669 | BK6H543 |
| 0.52% | IBRX | IMMUNITYBIO INC | -- | $474,821.64 | 45,481 | BNSP0B8 |
| 0.50% | ONC | BEONE MEDICINES LTD-ADR | -- | $457,079.44 | 1,454 | BYYWPW6 |
| 0.50% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $456,529.76 | 1,048 | BD59BS7 |
| 0.47% | TEM | TEMPUS AI INC-CL A | -- | $425,520.42 | 7,982 | BSLSJJ0 |
| 0.44% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $403,413.43 | 6,271 | BYQBFJ8 |
| 0.43% | AXSM | AXSOME THERAPEUTICS INC | -- | $387,166.26 | 2,327 | BYZR4X4 |
| 0.42% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $381,831.45 | 1,155 | BQ721R4 |
| 0.42% | HALO | HALOZYME THERAPEUTICS INC | -- | $379,285.50 | 5,430 | 2975098 |
| 0.41% | PCVX | VAXCYTE INC | -- | $374,607.12 | 6,044 | BKPVGH6 |
| 0.38% | CYTK | CYTOKINETICS INC | -- | $346,833.78 | 5,646 | BBBSBJ5 |
| 0.38% | KRYS | KRYSTAL BIOTECH INC | -- | $346,546.59 | 1,339 | BD6JX35 |
| 0.37% | NUVL | NUVALENT INC-A | -- | $337,802.15 | 3,335 | BMVBZD3 |
| 0.34% | ABVX | ABIVAX SA-ADR | -- | $308,337.86 | 2,726 | BLC89B2 |
| 0.34% | ACLX | ARCELLX INC | -- | $304,513.50 | 2,670 | BPCJ1Q2 |
| 0.33% | KYMR | KYMERA THERAPEUTICS INC | -- | $299,312.20 | 3,322 | BMPRZV5 |
| 0.32% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $292,605.08 | 3,082 | BF2YWG4 |
| 0.30% | COGT | COGENT BIOSCIENCES INC | -- | $275,652.32 | 7,088 | BLR6XK8 |
| 0.30% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $272,070.88 | 2,887 | BDCBCD8 |
| 0.30% | CAI | CARIS LIFE SCIENCES INC | -- | $269,179.14 | 13,029 | BT18HP9 |
| 0.29% | CRSP | CRISPR THERAPEUTICS AG | -- | $267,388.00 | 4,400 | BDHF4K6 |
| 0.27% | PTCT | PTC THERAPEUTICS INC | -- | $246,033.59 | 3,707 | B17VCN9 |
| 0.25% | ALKS | ALKERMES PLC | -- | $230,626.00 | 7,624 | B3P6D26 |
| 0.25% | IMVT | IMMUNOVANT INC | -- | $224,608.50 | 8,094 | BJRFSB7 |
| 0.24% | CGON | CG ONCOLOGY INC | -- | $215,156.00 | 3,725 | BRBCSP4 |
| 0.24% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $213,783.57 | 2,373 | BJDX8Y8 |
| 0.23% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $204,790.80 | 4,710 | BFZQ0L8 |
| 0.23% | FOLD | AMICUS THERAPEUTICS INC | -- | $204,586.92 | 14,247 | B19FQ48 |
| 0.22% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $199,885.32 | 14,516 | BFNF1D6 |
| 0.21% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $194,109.40 | 3,086 | BQS9486 |
| 0.21% | ERAS | ERASCA INC | -- | $190,357.53 | 13,101 | BNLYBF3 |
| 0.20% | INDV | INDIVIOR PHARMACEUTICALS INC | -- | $184,300.74 | 5,763 | BTZRLN8 |
| 0.20% | LGND | LIGAND PHARMACEUTICALS | -- | $184,117.95 | 909 | 2501578 |
| 0.20% | ADMA | ADMA BIOLOGICS INC | -- | $182,214.20 | 10,990 | B9NSBM2 |
| 0.20% | APGE | APOGEE THERAPEUTICS INC | -- | $179,556.78 | 2,532 | BM9HHL5 |
| 0.20% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $178,259.76 | 4,382 | BDD19F8 |
| 0.20% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $178,191.72 | 7,812 | 2713317 |
| 0.19% | TERN | TERNS PHARMACEUTICALS INC | -- | $174,844.80 | 4,160 | BMDJ0C9 |
| 0.19% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $171,897.88 | 5,236 | BP8JSP4 |
| 0.17% | SYRE | SPYRE THERAPEUTICS INC | -- | $152,241.67 | 3,583 | BQBBDY8 |
| 0.17% | TARS | TARSUS PHARMACEUTICALS INC | -- | $151,840.23 | 1,961 | BMH5RL1 |
| 0.17% | XENE | XENON PHARMACEUTICALS INC | -- | $151,818.40 | 3,568 | BRJ3GY4 |
| 0.16% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $145,878.32 | 2,648 | B72ZBG4 |
| 0.16% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $145,203.30 | 4,889 | BKY5JZ8 |
| 0.16% | DNLI | DENALI THERAPEUTICS INC | -- | $142,212.00 | 6,772 | BD2B4V0 |
| 0.15% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $140,042.56 | 5,656 | BKX9VD3 |
| 0.15% | BEAM | BEAM THERAPEUTICS INC | -- | $134,412.65 | 4,685 | BK6L288 |
| 0.15% | IDYA | IDEAYA BIOSCIENCES INC | -- | $133,745.92 | 4,048 | BK0VHF6 |
| 0.15% | ALMS | ALUMIS INC | -- | $133,413.08 | 4,489 | BPLQG36 |
| 0.14% | VCYT | VERACYTE INC | -- | $131,436.50 | 3,650 | BFTWZY0 |
| 0.14% | TWST | TWIST BIOSCIENCE CORP | -- | $129,547.47 | 2,823 | BGKG6G7 |
| 0.14% | TXG | 10X GENOMICS INC-CLASS A | -- | $124,470.06 | 5,379 | BKS3RS7 |
| 0.13% | TVTX | TRAVERE THERAPEUTICS INC | -- | $121,988.43 | 4,131 | BLFGJD5 |
| 0.13% | APLS | APELLIS PHARMACEUTICALS INC | -- | $120,867.30 | 5,839 | BYTQ6X1 |
| 0.13% | VERA | VERA THERAPEUTICS INC | -- | $119,239.00 | 2,950 | BL55460 |
| 0.13% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $118,102.05 | 4,455 | BLB0YQ9 |
| 0.13% | IRON | DISC MEDICINE INC | -- | $116,045.76 | 1,744 | BMGJZJ8 |
| 0.13% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $113,629.88 | 7,049 | BJ5FZ74 |
| 0.12% | OCUL | OCULAR THERAPEUTIX INC | -- | $108,010.26 | 9,837 | BNZB1X8 |
| 0.12% | MLYS | MINERALYS THERAPEUTICS INC | -- | $107,135.28 | 3,654 | BP9N0G0 |
| 0.12% | WVE | WAVE LIFE SCIENCES LTD | -- | $106,963.55 | 7,723 | BYZG9R0 |
| 0.12% | DYN | DYNE THERAPEUTICS INC | -- | $106,509.25 | 6,595 | BN15WD1 |
| 0.11% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $102,554.10 | 4,455 | BJ62Z18 |
| 0.11% | MAZE | MAZE THERAPEUTICS INC | -- | $101,345.42 | 2,222 | BSRK699 |
| 0.11% | STOK | STOKE THERAPEUTICS INC | -- | $96,788.22 | 2,638 | BJQ05Z6 |
| 0.11% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $95,956.00 | 2,086 | BRXB0C0 |
| 0.10% | GRAL | GRAIL INC | -- | $94,734.00 | 1,800 | BSLSSX7 |
| 0.10% | HROW | HARROW INC | -- | $91,638.90 | 1,710 | BHNDW86 |
| 0.10% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $88,869.96 | 4,014 | BN7Q7R7 |
| 0.10% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $87,240.64 | 3,632 | BMZ4LN0 |
| 0.10% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $86,510.48 | 6,088 | BFWLC09 |
| 0.09% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $86,187.09 | 23,743 | BM9FJ13 |
| 0.09% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $83,900.86 | 9,722 | 2100362 |
| 0.09% | PHVS | PHARVARIS NV | -- | $82,824.00 | 2,958 | BMZ2X38 |
| 0.09% | NTLA | INTELLIA THERAPEUTICS INC | -- | $82,573.12 | 5,348 | BYZM6C2 |
| 0.09% | VCEL | VERICEL CORP | -- | $82,565.60 | 2,335 | BSBMN89 |
| 0.09% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $80,859.50 | 2,741 | BMFD115 |
| 0.09% | ZYME | ZYMEWORKS INC | -- | $80,559.36 | 3,456 | BPCQZY9 |
| 0.09% | TYRA | TYRA BIOSCIENCES INC | -- | $80,129.28 | 2,464 | BMVNDH9 |
| 0.09% | GMAB | GENMAB A/S -SP ADR | -- | $80,025.35 | 2,699 | BBC9WC7 |
| 0.09% | SRPT | SAREPTA THERAPEUTICS INC | -- | $78,956.16 | 4,838 | B8DPDT7 |
| 0.09% | INVA | INNOVIVA INC | -- | $78,831.99 | 3,453 | BDDXF67 |
| 0.09% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $78,606.40 | 2,692 | BCBVTX1 |
| 0.09% | RLAY | RELAY THERAPEUTICS INC | -- | $78,349.37 | 8,003 | BN2R582 |
| 0.09% | DFTX | DEFINIUM THERAPEUTICS INC | -- | $78,134.64 | 4,548 | BV2DHY6 |
| 0.09% | ANIP | ANI PHARMACEUTICALS INC | -- | $78,003.14 | 1,037 | BCDWBX6 |
| 0.09% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $77,586.30 | 5,071 | BPCK358 |
| 0.08% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $76,874.00 | 2,660 | BKSGZN7 |
| 0.08% | NVAX | NOVAVAX INC | -- | $75,865.44 | 7,504 | BJDQXG4 |
| 0.08% | ORKA | ORUKA THERAPEUTICS INC | -- | $75,330.84 | 2,236 | BKVF0J2 |
| 0.08% | TRVI | TREVI THERAPEUTICS INC | -- | $74,426.97 | 5,921 | BJH9ZN0 |
| 0.08% | NRIX | NURIX THERAPEUTICS INC | -- | $73,990.80 | 4,680 | BMVLGP2 |
| 0.08% | ARDX | ARDELYX INC | -- | $72,593.40 | 11,220 | BN89V40 |
| 0.08% | TNGX | TANGO THERAPEUTICS INC | -- | $71,705.07 | 6,219 | BP2P6L0 |
| 0.08% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $71,694.72 | 3,888 | BMX9K07 |
| 0.08% | ANAB | ANAPTYSBIO INC | -- | $70,174.98 | 1,278 | BDRW1L7 |
| 0.08% | EYPT | EYEPOINT INC | -- | $70,095.48 | 3,822 | BMGS7L1 |
| 0.08% | NVCR | NOVOCURE LTD | -- | $69,911.92 | 5,171 | BYSS4X4 |
| 0.08% | SION | SIONNA THERAPEUTICS INC | -- | $69,909.12 | 2,061 | BQKXDX4 |
| 0.08% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $69,470.70 | 18,330 | BF0DMK7 |
| 0.08% | MBX | MBX BIOSCIENCES INC | -- | $68,346.81 | 2,073 | BQXJKH2 |
| 0.07% | KOD | KODIAK SCIENCES INC | -- | $67,032.00 | 2,450 | BFXC933 |
| 0.07% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $65,830.05 | 2,015 | BLCD809 |
| 0.07% | ZBIO | ZENAS BIOPHARMA INC | -- | $63,337.68 | 2,478 | BQB42H3 |
| 0.07% | RAPP | RAPPORT THERAPEUTICS INC | -- | $62,442.37 | 2,201 | BR3T9B6 |
| 0.07% | ORIC | ORIC PHARMACEUTICALS INC | -- | $62,418.36 | 4,497 | BKVDFF7 |
| 0.07% | ATAI | ATAIBECKLEY INC | -- | $61,713.60 | 16,770 | BWJDYK1 |
| 0.07% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $61,702.61 | 3,449 | BYP80F1 |
| 0.07% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $60,736.00 | 1,460 | BX7RSN3 |
| 0.07% | VIR | VIR BIOTECHNOLOGY INC | -- | $60,000.16 | 6,424 | BK4PZ38 |
| 0.07% | SEPN | SEPTERNA INC | -- | $59,198.88 | 2,067 | BQNKXX2 |
| 0.07% | PGEN | PRECIGEN INC | -- | $59,143.56 | 16,338 | BKM5C84 |
| 0.06% | TSHA | TAYSHA GENE THERAPIES INC | -- | $57,295.44 | 12,648 | BNC1BX1 |
| 0.06% | ALVO | ALVOTECH SA | -- | $57,237.84 | 14,454 | BPNTJ34 |
| 0.06% | SVRA | SAVARA INC | -- | $56,463.95 | 9,395 | BYXGN81 |
| 0.06% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $55,629.50 | 3,007 | BP7KZP7 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $52,800.04 | 13,822 | BL53SR3 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $52,073.28 | 672 | BNSP8K3 |
| 0.06% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $51,594.84 | 946 | BL95N25 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $51,203.97 | 5,633 | B8K7T65 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $51,045.00 | 12,300 | BMFJJ97 |
| 0.05% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $49,164.17 | 4,741 | BLB0YH0 |
| 0.05% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $46,125.24 | 7,662 | BLR7H87 |
| 0.05% | VTYX | VENTYX BIOSCIENCES INC | -- | $46,064.10 | 3,295 | BMG99Y1 |
| 0.05% | GHRS | GH RESEARCH PLC | -- | $45,852.64 | 2,864 | BP6C0S2 |
| 0.05% | GERN | GERON CORP | -- | $45,687.80 | 29,476 | 2370381 |
| 0.05% | FTRE | FORTREA HOLDINGS INC | -- | $45,048.96 | 4,266 | BRXYZ57 |
| 0.05% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $44,583.22 | 2,122 | BNFWZS4 |
| 0.05% | BCAX | BICARA THERAPEUTICS INC | -- | $44,502.70 | 2,530 | BQB42F1 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $44,343.00 | 2,340 | BMNDK09 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $44,181.08 | 1,906 | BMGTLY5 |
| 0.05% | CGEM | CULLINAN THERAPEUTICS INC | -- | $43,620.72 | 2,728 | BM90J52 |
| 0.05% | MNKD | MANNKIND CORP | -- | $43,036.30 | 14,180 | BF081J4 |
| 0.05% | PCRX | PACIRA BIOSCIENCES INC | -- | $42,262.08 | 1,986 | B3X26D8 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $41,851.88 | 4,564 | BMCR7V2 |
| 0.05% | CTMX | CYTOMX THERAPEUTICS INC | -- | $41,774.82 | 7,823 | BYWVTY5 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $41,474.27 | 8,881 | BZ0QMB7 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $41,121.24 | 2,162 | BZ7PJQ1 |
| 0.04% | XNCR | XENCOR INC | -- | $40,565.40 | 3,298 | BGCYWN8 |
| 0.04% | ARVN | ARVINAS INC | -- | $39,701.35 | 2,965 | BDZ30Q0 |
| 0.04% | OMER | OMEROS CORP | -- | $39,222.52 | 3,274 | B4NB858 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $38,841.10 | 8,335 | BPBJFM7 |
| 0.04% | CSTL | CASTLE BIOSCIENCES INC | -- | $37,730.52 | 1,348 | BKLCWZ3 |
| 0.04% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $37,646.10 | 3,285 | BJLKVS6 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $37,484.04 | 2,334 | BD06CS0 |
| 0.04% | JANX | JANUX THERAPEUTICS INC | -- | $37,267.34 | 2,777 | BMFX8Y7 |
| 0.04% | PSNL | PERSONALIS INC | -- | $37,155.06 | 4,101 | BJQ0608 |
| 0.04% | ANNX | ANNEXON INC | -- | $36,890.16 | 6,683 | BMVV9R5 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $36,094.26 | 11,038 | BBNBTD2 |
| 0.04% | BIOA | BIOAGE LABS INC | -- | $35,951.76 | 1,656 | BT9K6D8 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $34,876.24 | 4,018 | BYZD465 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $33,303.36 | 1,808 | BD9GVY0 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $32,850.64 | 2,264 | BQS7491 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $30,544.02 | 4,351 | BMC3HS7 |
| 0.03% | QURE | UNIQURE NV | -- | $30,208.50 | 2,877 | BJFSR88 |
| 0.03% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $29,011.56 | 838 | BQD3J33 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $28,174.86 | 3,717 | BFYQFJ2 |
| 0.03% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $27,499.05 | 10,377 | BFZNYB7 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $26,904.90 | 2,630 | BMFK3H6 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $26,817.84 | 7,512 | B3MZ6K5 |
| 0.03% | CRMD | CORMEDIX INC | -- | $26,229.98 | 3,638 | BJ0LT31 |
| 0.03% | REPL | REPLIMUNE GROUP INC | -- | $25,933.52 | 3,622 | BDDVW37 |
| 0.03% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $24,800.30 | 4,990 | BDFKQ07 |
| 0.03% | NMRA | NEUMORA THERAPEUTICS INC | -- | $24,688.00 | 7,715 | BN4JN37 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $24,612.54 | 2,638 | BKLXFX5 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $24,172.56 | 6,696 | BMCWKZ2 |
| 0.03% | KMDA | KAMADA LTD | -- | $24,162.48 | 2,664 | B2Q9833 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $24,028.10 | 3,370 | BQ6C357 |
| 0.03% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $23,714.93 | 5,633 | BYVQJ96 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $23,634.00 | 2,600 | BLFBZ32 |
| 0.03% | LYEL | LYELL IMMUNOPHARMA INC | -- | $23,593.90 | 979 | BTNMG41 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $23,359.00 | 2,485 | B91XRN2 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $22,772.12 | 668 | B292NQ7 |
| 0.02% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $22,584.42 | 13,941 | B4N8MH9 |
| 0.02% | ETON | ETON PHARMACEUTICALS INC | -- | $22,487.85 | 1,239 | BGL0JK3 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $22,307.60 | 3,598 | BQHN6C7 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $22,295.93 | 2,729 | B12W3P6 |
| 0.02% | IVVD | INVIVYD INC | -- | $22,009.12 | 12,796 | BM8NHS1 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $21,660.85 | 3,307 | 2107437 |
| 0.02% | RGNX | REGENXBIO INC | -- | $21,593.88 | 2,337 | BZ0G875 |
| 0.02% | PEPG | PEPGEN INC | -- | $20,732.75 | 3,175 | BMTX3D7 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $20,674.19 | 3,953 | BMXNGZ6 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $20,615.20 | 1,765 | BP81RK8 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $20,047.04 | 4,819 | BFY7DC4 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $19,872.00 | 864 | BPBPCG8 |
| 0.02% | LENZ | LENZ THERAPEUTICS INC | -- | $19,767.60 | 1,445 | BQV0J03 |
| 0.02% | KROS | KEROS THERAPEUTICS INC | -- | $19,557.46 | 1,406 | BM7V485 |
| 0.02% | FULC | FULCRUM THERAPEUTICS INC | -- | $19,517.19 | 2,499 | BJDX8Z9 |
| 0.02% | ABSI | ABSCI CORP | -- | $19,443.20 | 6,944 | BN94K69 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $19,327.32 | 1,332 | B9L5200 |
| 0.02% | UPB | UPSTREAM BIO INC | -- | $19,211.50 | 2,495 | BRCFFK6 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $18,686.25 | 4,125 | BYTYP72 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $18,002.48 | 2,932 | BP81R42 |
| 0.02% | AVIR | ATEA PHARMACEUTICALS INC | -- | $17,566.09 | 3,607 | BLN9Z50 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $17,215.73 | 2,023 | BSMLR16 |
| 0.02% | NBP | NOVABRIDGE BIOSCIENCES | -- | $16,563.45 | 4,801 | BKRRKY7 |
| 0.02% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $16,367.78 | 1,067 | BPRBTY7 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $15,467.54 | 9,262 | BFMLGR4 |
| 0.02% | ACRS | ACLARIS THERAPEUTICS INC | -- | $15,259.15 | 5,003 | BYV2W40 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $15,039.36 | 2,611 | BMF7DT9 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $14,932.92 | 2,326 | B7F2TY6 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $14,905.00 | 2,981 | BMVBZF5 |
| 0.02% | NGNE | NEUROGENE INC | -- | $14,829.10 | 715 | BS2F741 |
| 0.02% | CABA | CABALETTA BIO INC | -- | $14,668.50 | 4,445 | BK5MWR1 |
| 0.02% | CCCC | C4 THERAPEUTICS INC | -- | $14,185.75 | 4,475 | BKX9NQ0 |
| 0.01% | ACIU | AC IMMUNE SA | -- | $13,351.68 | 4,636 | BZC0D70 |
| 0.01% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $12,970.62 | 2,169 | BL5B6Z1 |
| 0.01% | CADL | CANDEL THERAPEUTICS INC | -- | $12,953.85 | 2,535 | BP0TQC5 |
| 0.01% | EOLS | EVOLUS INC | -- | $12,839.97 | 2,993 | BDRJH21 |
| 0.01% | LFCR | LIFECORE BIOMEDICAL INC | -- | $12,507.90 | 1,730 | 2517058 |
| 0.01% | VOR | VOR BIOPHARMA INC | -- | $12,370.20 | 778 | BRJJYT3 |
| 0.01% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $12,239.28 | 2,136 | BKDQKM6 |
| 0.01% | OABI | OMNIAB INC | -- | $11,698.72 | 6,647 | BN13S71 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $11,418.66 | 2,607 | BPRB2N7 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $11,292.15 | 2,721 | BY7RB53 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $10,955.20 | 1,312 | BKC9SX3 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $9,692.20 | 4,508 | BZ8FPH3 |
| 0.01% | HUMA | HUMACYTE INC | -- | $9,684.64 | 8,647 | BMYTJP4 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $9,208.65 | 5,581 | BRK0149 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $8,428.60 | 9,030 | BNR5QT9 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $8,191.04 | 1,432 | BP2NYN2 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $7,941.44 | 4,316 | BNYJR68 |
| 0.01% | MENS | JYONG BIOTECH LTD | -- | $7,724.20 | 3,511 | BPTK6Z2 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $6,393.33 | 2,631 | BKTV702 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $6,125.44 | 4,504 | BNNXX18 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $5,880.98 | 2,471 | BP7L561 |
| 0.01% | AARD | AARDVARK THERAPEUTICS INC | -- | $5,497.35 | 1,005 | BTXQTX3 |
| 0.01% | GOSS | GOSSAMER BIO INC | -- | $4,580.45 | 10,687 | BJ0CK86 |
| -- | TNYA | TENAYA THERAPEUTICS INC | -- | $4,382.16 | 7,688 | BNNXX52 |
| -- | CDXS | CODEXIS INC | -- | $4,254.42 | 4,171 | B5LL2C2 |
| -- | PYXS | PYXIS ONCOLOGY INC | -- | $4,226.25 | 2,875 | BLBR8D5 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $20.55 | 01 | BTFHQP5 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| 40.98% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 37,207,463 | -- | 6,189 | -- |
| 28.41% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 25,796,934 | -- | 4,291 | -- |
| 25.33% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 23,001,415 | -- | 3,826 | -- |
| 17.47% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 15,865,325 | -- | 2,639 | -- |
| 16.45% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,933,485 | -- | 2,484 | -- |
| 4.19% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,805,514 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $29,300,448.10 | 29,300,448 | -- |
Index
as of 12/31/2025
- Total Number of Companies262
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$7.32 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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