BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 11/30/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 16.90% | 51.72% | 95.62% | 66.67% | 42.59% | 11.36% | 1.61% | 2.01% | 16.86% | 04/07/2010 |
| BIB Market Price | 17.00% | 51.90% | 95.85% | 66.74% | 42.98% | 11.47% | 1.66% | 2.03% | 16.87% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/17/2025- NAV $78.41
- NAV Change $-0.90
- Market Price $78.37
- Market Price Change $-0.95
- Trading Volume (M) 6,322
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/17/2025- NAV $78.41
- NAV Change $-0.90
- Market Price $78.37
- Market Price Change $-0.95
- Trading Volume (M) 6,322
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 12/17/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.52% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $4,542,399.60 | 10,105 | 2931034 |
| 5.44% | AMGN | AMGEN INC | -- | $4,477,095.33 | 13,733 | 2023607 |
| 5.16% | GILD | GILEAD SCIENCES INC | -- | $4,244,566.00 | 34,975 | 2369174 |
| 4.49% | REGN | REGENERON PHARMACEUTICALS | -- | $3,698,714.07 | 4,933 | 2730190 |
| 2.96% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,433,764.70 | 6,207 | B00FWN1 |
| 2.70% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $2,221,878.36 | 24,726 | 2989044 |
| 2.43% | INSM | INSMED INC | -- | $2,002,659.86 | 10,091 | 2614487 |
| 1.53% | ARGX | ARGENX SE - ADR | -- | $1,260,317.10 | 1,462 | BDVLM39 |
| 1.46% | BIIB | BIOGEN INC | -- | $1,204,700.00 | 7,000 | 2455965 |
| 1.34% | UTHR | UNITED THERAPEUTICS CORP | -- | $1,103,119.46 | 2,159 | 2430412 |
| 1.15% | ILMN | ILLUMINA INC | -- | $950,840.84 | 7,339 | 2613990 |
| 1.11% | INCY | INCYTE CORP | -- | $910,302.12 | 9,324 | 2471950 |
| 0.96% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $790,756.71 | 20,641 | BMVP7Y0 |
| 0.91% | MEDP | MEDPACE HOLDINGS INC | -- | $747,030.87 | 1,341 | BDCBC61 |
| 0.90% | ROIV | ROIVANT SCIENCES LTD | -- | $740,133.50 | 32,605 | BMW4NZ9 |
| 0.83% | RVMD | REVOLUTION MEDICINES INC | -- | $684,904.50 | 8,925 | BL71K91 |
| 0.82% | BBIO | BRIDGEBIO PHARMA INC | -- | $675,654.56 | 9,128 | BK1KWG8 |
| 0.82% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $671,091.20 | 4,736 | 2623911 |
| 0.79% | VTRS | VIATRIS INC | -- | $651,292.20 | 55,666 | BMWS3X9 |
| 0.75% | SNY | SANOFI-ADR | -- | $616,721.54 | 12,811 | 2964557 |
| 0.73% | SMMT | SUMMIT THERAPEUTICS INC | -- | $603,310.68 | 35,468 | BMTVQS7 |
| 0.72% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $589,192.10 | 2,905 | BV9G6B8 |
| 0.71% | IONS | IONIS PHARMACEUTICALS INC | -- | $586,578.80 | 7,610 | BDJ0LS6 |
| 0.71% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $581,146.16 | 1,064 | BD59BS7 |
| 0.70% | GH | GUARDANT HEALTH INC | -- | $580,336.38 | 5,954 | BFXC911 |
| 0.69% | MRNA | MODERNA INC | -- | $566,784.27 | 18,577 | BGSXTS3 |
| 0.66% | EXEL | EXELIXIS INC | -- | $539,826.00 | 12,853 | 2576941 |
| 0.63% | TEM | TEMPUS AI INC | -- | $520,473.83 | 8,055 | BSLSJJ0 |
| 0.60% | ONC | BEONE MEDICINES LTD-ADR | -- | $491,210.25 | 1,605 | BYYWPW6 |
| 0.58% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $477,593.84 | 2,896 | B4Q5ZN4 |
| 0.58% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $475,161.40 | 9,173 | 2437071 |
| 0.54% | RNA | AVIDITY BIOSCIENCES INC | -- | $441,497.41 | 6,143 | BMWHPY1 |
| 0.53% | BNTX | BIONTECH SE-ADR | -- | $439,954.80 | 4,803 | BK6H543 |
| 0.52% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $427,744.80 | 6,601 | BYQBFJ8 |
| 0.45% | HALO | HALOZYME THERAPEUTICS INC | -- | $367,325.45 | 5,585 | 2975098 |
| 0.43% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $354,931.78 | 3,173 | BF2YWG4 |
| 0.43% | AXSM | AXSOME THERAPEUTICS INC | -- | $352,684.00 | 2,383 | BYZR4X4 |
| 0.42% | CYTK | CYTOKINETICS INC | -- | $341,751.66 | 5,713 | BBBSBJ5 |
| 0.40% | KRYS | KRYSTAL BIOTECH INC | -- | $325,875.60 | 1,382 | BD6JX35 |
| 0.39% | NUVL | NUVALENT INC-A | -- | $322,278.75 | 3,183 | BMVBZD3 |
| 0.35% | PTCT | PTC THERAPEUTICS INC | -- | $284,247.42 | 3,793 | B17VCN9 |
| 0.34% | KYMR | KYMERA THERAPEUTICS INC | -- | $280,186.98 | 3,414 | BMPRZV5 |
| 0.32% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $267,189.30 | 1,005 | BQ721R4 |
| 0.32% | PCVX | VAXCYTE INC | -- | $266,928.94 | 6,199 | BKPVGH6 |
| 0.32% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $265,339.80 | 2,970 | BDCBCD8 |
| 0.32% | COGT | COGENT BIOSCIENCES INC | -- | $263,131.50 | 6,670 | BLR6XK8 |
| 0.29% | CRSP | CRISPR THERAPEUTICS AG | -- | $237,735.82 | 4,343 | BDHF4K6 |
| 0.27% | IMVT | IMMUNOVANT INC | -- | $224,554.54 | 8,323 | BJRFSB7 |
| 0.27% | ALKS | ALKERMES PLC | -- | $221,011.28 | 7,882 | B3P6D26 |
| 0.26% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $216,921.15 | 8,055 | 2713317 |
| 0.26% | ADMA | ADMA BIOLOGICS INC | -- | $214,549.02 | 11,394 | B9NSBM2 |
| 0.26% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $214,461.93 | 4,497 | BDD19F8 |
| 0.26% | INDV | INDIVIOR PLC | -- | $214,154.15 | 5,957 | BP0BQQ5 |
| 0.25% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $202,005.90 | 4,590 | BFZQ0L8 |
| 0.22% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $184,900.68 | 14,996 | BFNF1D6 |
| 0.22% | LGND | LIGAND PHARMACEUTICALS | -- | $182,136.24 | 936 | 2501578 |
| 0.22% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $181,131.04 | 5,378 | BP8JSP4 |
| 0.21% | TERN | TERNS PHARMACEUTICALS INC | -- | $175,392.44 | 4,178 | BMDJ0C9 |
| 0.21% | ACLX | ARCELLX INC | -- | $171,378.56 | 2,648 | BPCJ1Q2 |
| 0.21% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $170,194.86 | 2,838 | BQS9486 |
| 0.20% | APGE | APOGEE THERAPEUTICS INC | -- | $166,251.00 | 2,202 | BM9HHL5 |
| 0.20% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $165,531.00 | 2,399 | BJDX8Y8 |
| 0.20% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $162,246.50 | 5,725 | BKX9VD3 |
| 0.20% | FOLD | AMICUS THERAPEUTICS INC | -- | $161,887.00 | 14,717 | B19FQ48 |
| 0.19% | VCYT | VERACYTE INC | -- | $158,540.76 | 3,756 | BFTWZY0 |
| 0.19% | XENE | XENON PHARMACEUTICALS INC | -- | $158,362.82 | 3,682 | BRJ3GY4 |
| 0.19% | TARS | TARSUS PHARMACEUTICALS INC | -- | $156,784.32 | 2,016 | BMH5RL1 |
| 0.19% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $152,799.21 | 4,601 | BJ62Z18 |
| 0.18% | APLS | APELLIS PHARMACEUTICALS INC | -- | $151,956.00 | 6,030 | BYTQ6X1 |
| 0.18% | VERA | VERA THERAPEUTICS INC | -- | $147,870.91 | 3,047 | BL55460 |
| 0.18% | GRAL | GRAIL INC | -- | $147,782.27 | 1,721 | BSLSSX7 |
| 0.18% | IRON | DISC MEDICINE INC | -- | $145,233.40 | 1,660 | BMGJZJ8 |
| 0.18% | TVTX | TRAVERE THERAPEUTICS INC | -- | $144,235.84 | 4,256 | BLFGJD5 |
| 0.17% | IDYA | IDEAYA BIOSCIENCES INC | -- | $141,160.05 | 4,185 | BK0VHF6 |
| 0.17% | CGON | CG ONCOLOGY INC | -- | $136,064.17 | 3,641 | BRBCSP4 |
| 0.16% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $130,503.75 | 2,677 | B72ZBG4 |
| 0.16% | DYN | DYNE THERAPEUTICS INC | -- | $128,387.70 | 6,793 | BN15WD1 |
| 0.15% | WVE | WAVE LIFE SCIENCES LTD | -- | $124,151.32 | 7,598 | BYZG9R0 |
| 0.15% | BEAM | BEAM THERAPEUTICS INC | -- | $123,648.00 | 4,830 | BK6L288 |
| 0.14% | DNLI | DENALI THERAPEUTICS INC | -- | $117,350.61 | 6,981 | BD2B4V0 |
| 0.14% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $117,208.52 | 7,271 | BJ5FZ74 |
| 0.14% | MLYS | MINERALYS THERAPEUTICS INC | -- | $117,168.30 | 3,165 | BP9N0G0 |
| 0.14% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $114,433.38 | 4,581 | BLB0YQ9 |
| 0.14% | OCUL | OCULAR THERAPEUTIX INC | -- | $113,985.76 | 8,308 | BNZB1X8 |
| 0.14% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $112,219.30 | 5,030 | BKY5JZ8 |
| 0.13% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $106,830.20 | 3,277 | BMZ4LN0 |
| 0.13% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $106,528.66 | 2,747 | BKSGZN7 |
| 0.12% | AVDL | AVADEL PHARMACEUTICALS | -- | $99,210.40 | 4,636 | BDGMC59 |
| 0.12% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $99,113.83 | 6,277 | BFWLC09 |
| 0.12% | SRPT | SAREPTA THERAPEUTICS INC | -- | $98,618.10 | 4,665 | B8DPDT7 |
| 0.12% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $95,486.04 | 20,403 | BM9FJ13 |
| 0.12% | SYRE | SPYRE THERAPEUTICS INC | -- | $95,345.04 | 2,884 | BQBBDY8 |
| 0.12% | IBRX | IMMUNITYBIO INC | -- | $95,230.63 | 45,133 | BNSP0B8 |
| 0.11% | TWST | TWIST BIOSCIENCE CORP | -- | $92,630.79 | 2,883 | BGKG6G7 |
| 0.11% | ZYME | ZYMEWORKS INC | -- | $91,842.51 | 3,589 | BPCQZY9 |
| 0.11% | VCEL | VERICEL CORP | -- | $87,687.60 | 2,409 | BSBMN89 |
| 0.11% | MNKD | MANNKIND CORP | -- | $87,460.50 | 14,650 | BF081J4 |
| 0.10% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $86,108.40 | 4,020 | BMX9K07 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $86,091.72 | 2,076 | BRXB0C0 |
| 0.10% | TXG | 10X GENOMICS INC-CLASS A | -- | $86,042.25 | 5,463 | BKS3RS7 |
| 0.10% | STOK | STOKE THERAPEUTICS INC | -- | $85,961.76 | 2,616 | BJQ05Z6 |
| 0.10% | ANIP | ANI PHARMACEUTICALS INC | -- | $85,314.60 | 1,036 | BCDWBX6 |
| 0.10% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $83,781.81 | 4,113 | BN7Q7R7 |
| 0.10% | HROW | HARROW INC | -- | $78,437.13 | 1,767 | BHNDW86 |
| 0.09% | ALVO | ALVOTECH SA | -- | $74,730.00 | 14,946 | BPNTJ34 |
| 0.09% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $73,545.60 | 1,504 | BX7RSN3 |
| 0.09% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $71,463.99 | 10,023 | 2100362 |
| 0.09% | TSHA | TAYSHA GENE THERAPIES INC | -- | $70,856.00 | 13,025 | BNC1BX1 |
| 0.09% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $70,598.30 | 2,774 | BCBVTX1 |
| 0.09% | TRVI | TREVI THERAPEUTICS INC | -- | $70,407.54 | 5,814 | BJH9ZN0 |
| 0.09% | FTRE | FORTREA HOLDINGS INC | -- | $70,183.65 | 4,335 | BRXYZ57 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $68,487.84 | 1,912 | BLCD809 |
| 0.08% | ARDX | ARDELYX INC | -- | $66,619.74 | 11,506 | BN89V40 |
| 0.08% | NRIX | NURIX THERAPEUTICS INC | -- | $66,466.50 | 3,650 | BMVLGP2 |
| 0.08% | RLAY | RELAY THERAPEUTICS INC | -- | $66,102.96 | 8,232 | BN2R582 |
| 0.08% | NVCR | NOVOCURE LTD | -- | $65,817.54 | 5,338 | BYSS4X4 |
| 0.08% | GMAB | GENMAB A/S -SP ADR | -- | $63,483.42 | 2,002 | BBC9WC7 |
| 0.07% | ANAB | ANAPTYSBIO INC | -- | $61,087.53 | 1,337 | BDRW1L7 |
| 0.07% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $60,413.21 | 5,599 | BRJZSK0 |
| 0.07% | QURE | UNIQURE NV | -- | $60,338.60 | 2,620 | BJFSR88 |
| 0.07% | INVA | INNOVIVA INC | -- | $60,330.45 | 3,009 | BDDXF67 |
| 0.07% | SANA | SANA BIOTECHNOLOGY INC | -- | $59,042.56 | 12,352 | BMFJJ97 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $57,875.40 | 2,220 | BNFWZS4 |
| 0.07% | TYRA | TYRA BIOSCIENCES INC | -- | $57,517.00 | 2,545 | BMVNDH9 |
| 0.07% | INBX | INHIBRX BIOSCIENCES INC | -- | $57,498.28 | 692 | BNSP8K3 |
| 0.07% | PCRX | PACIRA BIOSCIENCES INC | -- | $56,949.75 | 2,145 | B3X26D8 |
| 0.07% | PGEN | PRECIGEN INC | -- | $56,623.46 | 14,227 | BKM5C84 |
| 0.07% | CSTL | CASTLE BIOSCIENCES INC | -- | $54,929.10 | 1,385 | BKLCWZ3 |
| 0.07% | EYPT | EYEPOINT PHARMACEUTICALS INC | -- | $54,828.06 | 3,291 | BMGS7L1 |
| 0.07% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $53,892.90 | 7,710 | BLR7H87 |
| 0.07% | XNCR | XENCOR INC | -- | $53,799.00 | 3,405 | BGCYWN8 |
| 0.06% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $52,024.32 | 3,387 | BJLKVS6 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $51,900.75 | 5,825 | B8K7T65 |
| 0.06% | ORKA | ORUKA THERAPEUTICS INC | -- | $50,743.44 | 1,788 | BKVF0J2 |
| 0.06% | NVAX | NOVAVAX INC | -- | $50,640.15 | 7,755 | BJDQXG4 |
| 0.06% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $50,530.59 | 4,257 | BPCK358 |
| 0.06% | SVRA | SAVARA INC | -- | $50,419.72 | 8,252 | BYXGN81 |
| 0.06% | RAPP | RAPPORT THERAPEUTICS INC | -- | $49,989.24 | 1,743 | BR3T9B6 |
| 0.06% | URGN | UROGEN PHARMA LTD | -- | $49,967.58 | 2,209 | BZ7PJQ1 |
| 0.06% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $49,395.75 | 2,949 | BP7KZP7 |
| 0.06% | ERAS | ERASCA INC | -- | $49,300.16 | 13,544 | BNLYBF3 |
| 0.06% | ALMS | ALUMIS INC | -- | $48,943.08 | 4,626 | BPLQG36 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $47,797.80 | 14,268 | BL53SR3 |
| 0.06% | SPRY | ARS PHARMACEUTICALS INC | -- | $47,520.33 | 4,719 | BMCR7V2 |
| 0.06% | TNGX | TANGO THERAPEUTICS INC | -- | $46,639.36 | 5,312 | BP2P6L0 |
| 0.06% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $45,304.56 | 2,828 | BMFD115 |
| 0.05% | NTLA | INTELLIA THERAPEUTICS INC | -- | $45,048.75 | 5,125 | BYZM6C2 |
| 0.05% | MNMD | MIND MEDICINE MINDMED INC | -- | $44,068.29 | 3,633 | BPQYY97 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $43,538.04 | 17,277 | BF0DMK7 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $43,078.88 | 1,937 | BMGTLY5 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $43,073.55 | 2,405 | BMNDK09 |
| 0.05% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $42,845.16 | 4,891 | BLB0YH0 |
| 0.05% | GERN | GERON CORP | -- | $42,648.20 | 30,463 | 2370381 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $42,469.92 | 9,153 | BZ0QMB7 |
| 0.05% | KURA | KURA ONCOLOGY INC | -- | $42,185.92 | 4,144 | BYZD465 |
| 0.05% | MESO | MESOBLAST LTD- SPON ADR | -- | $42,149.80 | 2,254 | BQS7491 |
| 0.05% | ARVN | ARVINAS INC | -- | $41,113.76 | 3,508 | BDZ30Q0 |
| 0.05% | CRMD | CORMEDIX INC | -- | $40,807.80 | 3,564 | BJ0LT31 |
| 0.05% | VIR | VIR BIOTECHNOLOGY INC | -- | $40,726.62 | 6,633 | BK4PZ38 |
| 0.05% | JANX | JANUX THERAPEUTICS INC | -- | $40,452.90 | 2,869 | BMFX8Y7 |
| 0.05% | KROS | KEROS THERAPEUTICS INC | -- | $40,389.37 | 1,939 | BM7V485 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $39,463.20 | 972 | BL95N25 |
| 0.05% | ZLAB | ZAI LAB LTD-ADR | -- | $39,313.26 | 2,283 | BD9GVY0 |
| 0.05% | ORIC | ORIC PHARMACEUTICALS INC | -- | $38,116.14 | 4,637 | BKVDFF7 |
| 0.04% | REPL | REPLIMUNE GROUP INC | -- | $36,002.82 | 3,727 | BDDVW37 |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $35,900.64 | 856 | BQD3J33 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $35,729.10 | 2,406 | BD06CS0 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $35,138.55 | 9,627 | BBNBTD2 |
| 0.04% | ATXS | ASTRIA THERAPEUTICS INC | -- | $34,064.80 | 2,695 | BMYRFN8 |
| 0.04% | PSNL | PERSONALIS INC | -- | $32,771.16 | 4,234 | BJQ0608 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $32,518.88 | 5,776 | BYVQJ96 |
| 0.04% | RGNX | REGENXBIO INC | -- | $31,766.04 | 2,412 | BZ0G875 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $31,225.26 | 8,349 | BPBJFM7 |
| 0.04% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $31,150.51 | 3,841 | BFYQFJ2 |
| 0.04% | LYEL | LYELL IMMUNOPHARMA INC | -- | $29,408.19 | 917 | BTNMG41 |
| 0.03% | OMER | OMEROS CORP | -- | $28,688.67 | 3,249 | B4NB858 |
| 0.03% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $27,910.40 | 3,560 | BYP80F1 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $27,680.06 | 14,342 | B4N8MH9 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $27,149.80 | 4,379 | BMC3HS7 |
| 0.03% | CGEM | CULLINAN THERAPEUTICS INC | -- | $27,053.39 | 2,821 | BM90J52 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $26,137.72 | 7,756 | B3MZ6K5 |
| 0.03% | ANNX | ANNEXON INC | -- | $25,710.30 | 5,247 | BMVV9R5 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $24,235.10 | 2,570 | B91XRN2 |
| 0.03% | ABSI | ABSCI CORP | -- | $24,201.21 | 7,139 | BN94K69 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $24,090.34 | 2,719 | BMFK3H6 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $23,901.68 | 6,908 | BMCWKZ2 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $23,485.58 | 2,578 | BQ6C357 |
| 0.03% | LENZ | LENZ THERAPEUTICS INC | -- | $22,295.94 | 1,362 | BQV0J03 |
| 0.03% | EOLS | EVOLUS INC | -- | $21,870.12 | 3,089 | BDRJH21 |
| 0.03% | SIGA | SIGA TECHNOLOGIES INC | -- | $21,813.22 | 3,419 | 2107437 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $21,734.80 | 2,680 | BLFBZ32 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $21,566.52 | 684 | B292NQ7 |
| 0.03% | ALT | ALTIMMUNE INC | -- | $21,449.26 | 4,214 | BFY7DC4 |
| 0.02% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $20,538.30 | 2,230 | BKLXFX5 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $20,375.52 | 1,816 | BP81RK8 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $20,002.84 | 3,718 | BQHN6C7 |
| 0.02% | LXRX | LEXICON PHARMACEUTICALS INC | -- | $19,953.65 | 17,351 | BWFZX59 |
| 0.02% | HCM | HUTCHMED CHINA-ADR | -- | $19,638.06 | 1,481 | BYXV9H7 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $19,239.22 | 2,821 | B12W3P6 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $17,351.10 | 2,966 | BP81R42 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $16,847.04 | 5,152 | BDFKQ07 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $16,075.92 | 4,101 | BYTYP72 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $16,011.49 | 893 | BPBPCG8 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $15,338.65 | 2,207 | BKDQKM6 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $15,043.48 | 10,594 | BFZNYB7 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $14,940.12 | 9,577 | BFMLGR4 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $14,549.25 | 1,021 | B9L5200 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $14,269.15 | 2,065 | BSMLR16 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $14,141.02 | 4,087 | BMXNGZ6 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $14,094.36 | 4,794 | BZC0D70 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $14,012.50 | 2,242 | BL5B6Z1 |
| 0.02% | CLYM | CLIMB BIO INC | -- | $13,753.00 | 3,236 | BMW5LX6 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $13,685.64 | 7,732 | BN4JN37 |
| 0.02% | AMRN | AMARIN CORP PLC -ADR | -- | $13,221.99 | 963 | BN72KB0 |
| 0.02% | NGNE | NEUROGENE INC | -- | $13,034.34 | 681 | BS2F741 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $12,523.36 | 2,699 | BMF7DT9 |
| 0.01% | OABI | OMNIAB INC | -- | $12,069.54 | 5,859 | BN13S71 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $12,049.02 | 3,789 | BLN9Z50 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $12,008.50 | 2,555 | BP7L561 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $11,280.48 | 2,648 | BY7RB53 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $10,174.41 | 4,293 | BZ8FPH3 |
| 0.01% | PYXS | PYXIS ONCOLOGY INC | -- | $9,978.57 | 2,961 | BLBR8D5 |
| 0.01% | RNAC | CARTESIAN THERAPEUTICS INC | -- | $9,228.06 | 1,242 | BQB9HM8 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $8,456.44 | 1,297 | BKC9SX3 |
| 0.01% | PEPG | PEPGEN INC | -- | $8,252.82 | 1,566 | BMTX3D7 |
| 0.01% | HUMA | HUMACYTE INC | -- | $8,091.34 | 7,562 | BMYTJP4 |
| 0.01% | MXCT | MAXCYTE INC | -- | $7,584.10 | 5,090 | BKMQF66 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $6,965.90 | 3,398 | BKX9NQ0 |
| 0.01% | CDXS | CODEXIS INC | -- | $6,939.10 | 4,310 | B5LL2C2 |
| 0.01% | MRSN | MERSANA THERAPEUTICS INC | -- | $6,916.28 | 238 | BVPKH99 |
| 0.01% | ALEC | ALECTOR INC | -- | $6,524.55 | 4,833 | BJ4LDC4 |
| 0.01% | NKTX | NKARTA INC | -- | $6,002.07 | 3,391 | BK80YJ8 |
| 0.01% | FATE | FATE THERAPEUTICS INC | -- | $5,782.35 | 5,507 | BCZS820 |
| 0.01% | ARTV | ARTIVA BIOTHERAPEUTICS INC | -- | $5,037.12 | 1,166 | BMF1LJ7 |
| 0.01% | MGNX | MACROGENICS INC | -- | $4,858.98 | 3,018 | BFDV8K0 |
| -- | BMEA | BIOMEA FUSION INC | -- | $3,835.35 | 2,841 | BNKF6N0 |
| -- | -- | SUTRO BIOPHARMA INC COMMON STOCK USD 0.001 | -- | $3,697.65 | 405 | -- |
| -- | PLRX | PLIANT THERAPEUTICS INC | -- | $3,575.82 | 2,931 | BMDWW66 |
| -- | ACRV | ACRIVON THERAPEUTICS INC | -- | $3,469.62 | 1,502 | BP2TPK4 |
| -- | TVGN | TEVOGEN BIO HOLDINGS INC | -- | $3,465.65 | 9,392 | BPG5P75 |
| -- | TCRX | TSCAN THERAPEUTICS INC | -- | $2,326.14 | 2,505 | BNLYBJ7 |
| -- | OKUR | ONKURE THERAPEUTICS INC-A | -- | $1,802.22 | 613 | BT7KGT6 |
| -- | QTTB | Q32 BIO INC | -- | $1,676.16 | 582 | BS2FKQ4 |
| -- | APLT | APPLIED THERAPEUTICS INC | -- | $825.12 | 6,876 | BJL38Z1 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| 34.34% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 28,269,809 | -- | 5,008 | -- |
| 32.08% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 26,406,983 | -- | 4,678 | -- |
| 26.10% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 21,484,604 | -- | 3,806 | -- |
| 17.03% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,022,006 | -- | 2,484 | -- |
| 15.76% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 12,977,694 | -- | 2,299 | -- |
| 4.34% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,573,241 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $24,079,284.88 | 24,079,285 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
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