BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 12/31/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 2/06/2026- NAV $86.62
- NAV Change $+4.87
- Market Price $86.66
- Market Price Change $+4.92
- Trading Volume (M) 15,960
- 30-Day Median Bid Ask Spread 0.28%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 2/06/2026- NAV $86.62
- NAV Change $+4.87
- Market Price $86.66
- Market Price Change $+4.92
- Trading Volume (M) 15,960
- 30-Day Median Bid Ask Spread 0.28%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 12/31/2025
Holdings
as of 2/06/2026
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 6.78% | GILD | GILEAD SCIENCES INC | -- | $6,170,607.50 | 40,463 | 2369174 |
| 6.23% | AMGN | AMGEN INC | -- | $5,664,492.48 | 14,739 | 2023607 |
| 6.17% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,612,214.56 | 11,743 | 2931034 |
| 4.18% | REGN | REGENERON PHARMACEUTICALS | -- | $3,798,726.36 | 4,836 | 2730190 |
| 2.23% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,029,997.76 | 6,186 | B00FWN1 |
| 1.65% | INSM | INSMED INC | -- | $1,496,501.96 | 9,986 | 2614487 |
| 1.52% | BIIB | BIOGEN INC | -- | $1,381,905.42 | 6,869 | 2455965 |
| 1.22% | ARGX | ARGENX SE - ADR | -- | $1,106,006.35 | 1,363 | BDVLM39 |
| 1.10% | INCY | INCYTE CORP | -- | $996,320.88 | 9,192 | 2471950 |
| 1.08% | UTHR | UNITED THERAPEUTICS CORP | -- | $978,485.76 | 2,016 | 2430412 |
| 0.98% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $893,223.25 | 20,005 | BMVP7Y0 |
| 0.97% | RVMD | REVOLUTION MEDICINES INC | -- | $882,479.48 | 9,052 | BL71K91 |
| 0.94% | ILMN | ILLUMINA INC | -- | $856,476.88 | 7,154 | 2613990 |
| 0.92% | ROIV | ROIVANT SCIENCES LTD | -- | $840,802.48 | 32,564 | BMW4NZ9 |
| 0.86% | VTRS | VIATRIS INC | -- | $786,270.24 | 53,928 | BMWS3X9 |
| 0.82% | MRNA | MODERNA INC | -- | $750,154.92 | 18,292 | BGSXTS3 |
| 0.79% | MEDP | MEDPACE HOLDINGS INC | -- | $714,950.76 | 1,319 | BDCBC61 |
| 0.72% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $659,121.60 | 4,668 | 2623911 |
| 0.72% | IONS | IONIS PHARMACEUTICALS INC | -- | $656,016.00 | 7,584 | BDJ0LS6 |
| 0.70% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $638,681.25 | 2,875 | BV9G6B8 |
| 0.68% | GH | GUARDANT HEALTH INC | -- | $617,007.30 | 6,058 | BFXC911 |
| 0.68% | BBIO | BRIDGEBIO PHARMA INC | -- | $613,947.10 | 9,022 | BK1KWG8 |
| 0.65% | SNY | SANOFI-ADR | -- | $592,613.70 | 12,390 | 2964557 |
| 0.61% | EXEL | EXELIXIS INC | -- | $551,120.60 | 12,554 | 2576941 |
| 0.57% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $522,879.35 | 8,995 | 2437071 |
| 0.57% | SMMT | SUMMIT THERAPEUTICS INC | -- | $522,491.44 | 34,856 | BMTVQS7 |
| 0.57% | ONC | BEONE MEDICINES LTD-ADR | -- | $521,678.08 | 1,474 | BYYWPW6 |
| 0.57% | RNA | AVIDITY BIOSCIENCES INC | -- | $514,309.50 | 7,055 | BMWHPY1 |
| 0.56% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $507,688.80 | 1,063 | BD59BS7 |
| 0.55% | BNTX | BIONTECH SE-ADR | -- | $504,739.08 | 4,734 | BK6H543 |
| 0.52% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $470,847.50 | 2,845 | B4Q5ZN4 |
| 0.49% | HALO | HALOZYME THERAPEUTICS INC | -- | $447,252.38 | 5,506 | 2975098 |
| 0.49% | TEM | TEMPUS AI INC | -- | $444,441.54 | 8,094 | BSLSJJ0 |
| 0.47% | AXSM | AXSOME THERAPEUTICS INC | -- | $430,818.00 | 2,360 | BYZR4X4 |
| 0.45% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $410,282.68 | 6,359 | BYQBFJ8 |
| 0.41% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $374,216.47 | 1,171 | BQ721R4 |
| 0.41% | KRYS | KRYSTAL BIOTECH INC | -- | $370,380.92 | 1,358 | BD6JX35 |
| 0.39% | CYTK | CYTOKINETICS INC | -- | $356,896.50 | 5,725 | BBBSBJ5 |
| 0.39% | NUVL | NUVALENT INC-A | -- | $350,341.38 | 3,382 | BMVBZD3 |
| 0.38% | PCVX | VAXCYTE INC | -- | $344,143.35 | 6,129 | BKPVGH6 |
| 0.36% | ABVX | ABIVAX SA-ADR | -- | $325,239.88 | 2,764 | BLC89B2 |
| 0.36% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $323,781.25 | 3,125 | BF2YWG4 |
| 0.32% | CAI | CARIS LIFE SCIENCES INC | -- | $290,642.00 | 13,211 | BT18HP9 |
| 0.31% | PTCT | PTC THERAPEUTICS INC | -- | $280,722.12 | 3,759 | B17VCN9 |
| 0.31% | IBRX | IMMUNITYBIO INC | -- | $279,013.90 | 46,118 | BNSP0B8 |
| 0.30% | ALKS | ALKERMES PLC | -- | $269,889.21 | 7,731 | B3P6D26 |
| 0.29% | KYMR | KYMERA THERAPEUTICS INC | -- | $268,138.71 | 3,369 | BMPRZV5 |
| 0.29% | COGT | COGENT BIOSCIENCES INC | -- | $266,493.96 | 7,187 | BLR6XK8 |
| 0.27% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $247,302.23 | 2,927 | BDCBCD8 |
| 0.27% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $241,730.82 | 2,406 | BJDX8Y8 |
| 0.26% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $234,424.68 | 3,129 | BQS9486 |
| 0.25% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $227,433.12 | 4,776 | BFZQ0L8 |
| 0.24% | IMVT | IMMUNOVANT INC | -- | $221,999.35 | 8,207 | BJRFSB7 |
| 0.24% | CRSP | CRISPR THERAPEUTICS AG | -- | $217,477.88 | 4,462 | BDHF4K6 |
| 0.23% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $213,719.88 | 14,719 | BFNF1D6 |
| 0.23% | FOLD | AMICUS THERAPEUTICS INC | -- | $206,577.80 | 14,446 | B19FQ48 |
| 0.22% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $201,179.04 | 4,443 | BDD19F8 |
| 0.22% | INDV | INDIVIOR PHARMACEUTICALS INC | -- | $200,799.84 | 5,844 | BTZRLN8 |
| 0.21% | CGON | CG ONCOLOGY INC | -- | $190,209.72 | 3,777 | BRBCSP4 |
| 0.21% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $186,618.76 | 7,921 | 2713317 |
| 0.20% | ACLX | ARCELLX INC | -- | $184,157.21 | 2,707 | BPCJ1Q2 |
| 0.20% | ADMA | ADMA BIOLOGICS INC | -- | $183,095.92 | 11,144 | B9NSBM2 |
| 0.20% | GRAL | GRAIL INC | -- | $182,627.75 | 1,825 | BSLSSX7 |
| 0.20% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $182,098.70 | 5,309 | BP8JSP4 |
| 0.19% | LGND | LIGAND PHARMACEUTICALS | -- | $175,585.68 | 922 | 2501578 |
| 0.18% | ERAS | ERASCA INC | -- | $163,260.36 | 13,284 | BNLYBF3 |
| 0.18% | APGE | APOGEE THERAPEUTICS INC | -- | $159,770.08 | 2,567 | BM9HHL5 |
| 0.18% | TERN | TERNS PHARMACEUTICALS INC | -- | $159,313.86 | 4,218 | BMDJ0C9 |
| 0.17% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $156,680.20 | 5,735 | BKX9VD3 |
| 0.16% | XENE | XENON PHARMACEUTICALS INC | -- | $149,712.84 | 3,618 | BRJ3GY4 |
| 0.16% | DNLI | DENALI THERAPEUTICS INC | -- | $144,756.36 | 6,867 | BD2B4V0 |
| 0.16% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $144,248.70 | 4,957 | BKY5JZ8 |
| 0.16% | TWST | TWIST BIOSCIENCE CORP | -- | $140,974.12 | 2,863 | BGKG6G7 |
| 0.15% | IRON | DISC MEDICINE INC | -- | $140,944.96 | 1,768 | BMGJZJ8 |
| 0.15% | APLS | APELLIS PHARMACEUTICALS INC | -- | $139,084.29 | 5,921 | BYTQ6X1 |
| 0.15% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $138,680.25 | 2,685 | B72ZBG4 |
| 0.15% | VCYT | VERACYTE INC | -- | $133,939.19 | 3,701 | BFTWZY0 |
| 0.15% | IDYA | IDEAYA BIOSCIENCES INC | -- | $132,057.85 | 4,105 | BK0VHF6 |
| 0.14% | VERA | VERA THERAPEUTICS INC | -- | $130,108.50 | 2,991 | BL55460 |
| 0.14% | TARS | TARSUS PHARMACEUTICALS INC | -- | $128,464.56 | 1,988 | BMH5RL1 |
| 0.14% | SYRE | SPYRE THERAPEUTICS INC | -- | $127,590.96 | 3,633 | BQBBDY8 |
| 0.14% | BEAM | BEAM THERAPEUTICS INC | -- | $125,996.52 | 4,751 | BK6L288 |
| 0.14% | TVTX | TRAVERE THERAPEUTICS INC | -- | $124,455.19 | 4,189 | BLFGJD5 |
| 0.13% | ALMS | ALUMIS INC | -- | $119,216.88 | 4,552 | BPLQG36 |
| 0.12% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $112,723.96 | 7,148 | BJ5FZ74 |
| 0.12% | DYN | DYNE THERAPEUTICS INC | -- | $112,341.60 | 6,687 | BN15WD1 |
| 0.12% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $111,569.90 | 4,517 | BJ62Z18 |
| 0.12% | MLYS | MINERALYS THERAPEUTICS INC | -- | $110,297.85 | 3,705 | BP9N0G0 |
| 0.12% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $106,104.33 | 4,517 | BLB0YQ9 |
| 0.12% | WVE | WAVE LIFE SCIENCES LTD | -- | $105,326.95 | 7,831 | BYZG9R0 |
| 0.11% | TXG | 10X GENOMICS INC-CLASS A | -- | $101,498.94 | 5,454 | BKS3RS7 |
| 0.11% | MAZE | MAZE THERAPEUTICS INC | -- | $101,452.59 | 2,253 | BSRK699 |
| 0.11% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $100,517.19 | 2,697 | BKSGZN7 |
| 0.11% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $95,818.50 | 24,075 | BM9FJ13 |
| 0.10% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $93,400.88 | 3,683 | BMZ4LN0 |
| 0.10% | OCUL | OCULAR THERAPEUTIX INC | -- | $91,371.00 | 9,975 | BNZB1X8 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $91,135.35 | 2,115 | BRXB0C0 |
| 0.10% | SRPT | SAREPTA THERAPEUTICS INC | -- | $90,761.00 | 4,906 | B8DPDT7 |
| 0.10% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $89,138.12 | 6,173 | BFWLC09 |
| 0.10% | STOK | STOKE THERAPEUTICS INC | -- | $86,670.00 | 2,675 | BJQ05Z6 |
| 0.09% | ANIP | ANI PHARMACEUTICALS INC | -- | $86,095.68 | 1,052 | BCDWBX6 |
| 0.09% | VCEL | VERICEL CORP | -- | $85,697.92 | 2,368 | BSBMN89 |
| 0.09% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $85,510.70 | 4,070 | BN7Q7R7 |
| 0.09% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $85,219.00 | 5,498 | BRJZSK0 |
| 0.09% | GMAB | GENMAB A/S -SP ADR | -- | $84,573.30 | 2,737 | BBC9WC7 |
| 0.09% | ARDX | ARDELYX INC | -- | $83,279.64 | 11,377 | BN89V40 |
| 0.09% | MNKD | MANNKIND CORP | -- | $83,104.84 | 14,378 | BF081J4 |
| 0.09% | HROW | HARROW INC | -- | $82,052.88 | 1,734 | BHNDW86 |
| 0.09% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $81,758.18 | 2,779 | BMFD115 |
| 0.09% | NRIX | NURIX THERAPEUTICS INC | -- | $79,970.10 | 4,746 | BMVLGP2 |
| 0.09% | ZYME | ZYMEWORKS INC | -- | $79,610.88 | 3,504 | BPCQZY9 |
| 0.09% | PHVS | PHARVARIS NV | -- | $79,233.58 | 2,999 | BMZ2X38 |
| 0.09% | MBX | MBX BIOSCIENCES INC | -- | $79,182.34 | 2,102 | BQXJKH2 |
| 0.09% | TNGX | TANGO THERAPEUTICS INC | -- | $78,888.06 | 6,306 | BP2P6L0 |
| 0.09% | DFTX | DEFINIUM THERAPEUTICS INC | -- | $77,942.80 | 4,612 | BV2DHY6 |
| 0.09% | TYRA | TYRA BIOSCIENCES INC | -- | $77,469.00 | 2,499 | BMVNDH9 |
| 0.08% | INVA | INNOVIVA INC | -- | $76,321.80 | 3,501 | BDDXF67 |
| 0.08% | SION | SIONNA THERAPEUTICS INC | -- | $75,469.90 | 2,090 | BQKXDX4 |
| 0.08% | ALVO | ALVOTECH SA | -- | $75,038.72 | 14,656 | BPNTJ34 |
| 0.08% | ORKA | ORUKA THERAPEUTICS INC | -- | $74,924.35 | 2,267 | BKVF0J2 |
| 0.08% | RAPT | RAPT THERAPEUTICS INC | -- | $74,823.93 | 1,297 | BTJZB49 |
| 0.08% | QURE | UNIQURE NV | -- | $74,821.05 | 2,917 | BJFSR88 |
| 0.08% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $72,426.90 | 2,730 | BCBVTX1 |
| 0.08% | RLAY | RELAY THERAPEUTICS INC | -- | $72,385.80 | 8,115 | BN2R582 |
| 0.08% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $71,885.16 | 5,142 | BPCK358 |
| 0.08% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $71,548.62 | 3,497 | BYP80F1 |
| 0.08% | PGEN | PRECIGEN INC | -- | $71,072.43 | 16,567 | BKM5C84 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $70,462.80 | 1,480 | BX7RSN3 |
| 0.08% | TRVI | TREVI THERAPEUTICS INC | -- | $68,805.84 | 6,004 | BJH9ZN0 |
| 0.07% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $67,408.20 | 3,942 | BMX9K07 |
| 0.07% | NTLA | INTELLIA THERAPEUTICS INC | -- | $66,594.44 | 5,423 | BYZM6C2 |
| 0.07% | UPB | UPSTREAM BIO INC | -- | $66,286.00 | 2,530 | BRCFFK6 |
| 0.07% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $65,335.14 | 2,043 | BLCD809 |
| 0.07% | ANAB | ANAPTYSBIO INC | -- | $64,450.08 | 1,296 | BDRW1L7 |
| 0.07% | ATAI | ATAIBECKLEY INC | -- | $64,108.85 | 17,005 | BWJDYK1 |
| 0.07% | FTRE | FORTREA HOLDINGS INC | -- | $63,375.90 | 4,326 | BRXYZ57 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $62,967.52 | 2,152 | BNFWZS4 |
| 0.07% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $62,894.04 | 9,858 | 2100362 |
| 0.07% | NVAX | NOVAVAX INC | -- | $62,774.25 | 7,609 | BJDQXG4 |
| 0.07% | RAPP | RAPPORT THERAPEUTICS INC | -- | $60,464.88 | 2,232 | BR3T9B6 |
| 0.07% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $59,607.95 | 3,049 | BP7KZP7 |
| 0.07% | TSHA | TAYSHA GENE THERAPIES INC | -- | $59,123.25 | 12,825 | BNC1BX1 |
| 0.06% | KOD | KODIAK SCIENCES INC | -- | $57,231.36 | 2,484 | BFXC933 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $57,142.71 | 681 | BNSP8K3 |
| 0.06% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $54,847.87 | 4,807 | BLB0YH0 |
| 0.06% | ZBIO | ZENAS BIOPHARMA INC | -- | $54,783.40 | 2,513 | BQB42H3 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $54,460.69 | 7,769 | BLR7H87 |
| 0.06% | SEPN | SEPTERNA INC | -- | $53,259.36 | 2,096 | BQNKXX2 |
| 0.06% | NVCR | NOVOCURE LTD | -- | $53,164.02 | 5,243 | BYSS4X4 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $53,007.36 | 5,712 | B8K7T65 |
| 0.06% | EYPT | EYEPOINT INC | -- | $51,550.80 | 3,876 | BMGS7L1 |
| 0.06% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $50,894.13 | 959 | BL95N25 |
| 0.06% | SVRA | SAVARA INC | -- | $50,493.10 | 9,527 | BYXGN81 |
| 0.05% | SANA | SANA BIOTECHNOLOGY INC | -- | $49,014.96 | 12,472 | BMFJJ97 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $48,599.04 | 2,373 | BMNDK09 |
| 0.05% | ORIC | ORIC PHARMACEUTICALS INC | -- | $47,515.20 | 4,560 | BKVDFF7 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $47,025.11 | 18,587 | BF0DMK7 |
| 0.05% | VIR | VIR BIOTECHNOLOGY INC | -- | $46,835.66 | 6,514 | BK4PZ38 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $46,799.20 | 2,192 | BZ7PJQ1 |
| 0.05% | VTYX | VENTYX BIOSCIENCES INC | -- | $46,640.36 | 3,341 | BMG99Y1 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $46,418.84 | 4,628 | BMCR7V2 |
| 0.05% | GERN | GERON CORP | -- | $45,730.17 | 29,889 | 2370381 |
| 0.05% | CTMX | CYTOMX THERAPEUTICS INC | -- | $44,980.11 | 7,933 | BYWVTY5 |
| 0.05% | CSTL | CASTLE BIOSCIENCES INC | -- | $44,769.25 | 1,367 | BKLCWZ3 |
| 0.05% | ABCL | ABCELLERA BIOLOGICS INC | -- | $44,287.40 | 14,015 | BL53SR3 |
| 0.05% | GHRS | GH RESEARCH PLC | -- | $44,039.16 | 2,904 | BP6C0S2 |
| 0.05% | PCRX | PACIRA BIOSCIENCES INC | -- | $42,294.00 | 2,014 | B3X26D8 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $42,255.38 | 1,933 | BMGTLY5 |
| 0.05% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $41,903.98 | 3,331 | BJLKVS6 |
| 0.04% | ARVN | ARVINAS INC | -- | $40,534.36 | 3,007 | BDZ30Q0 |
| 0.04% | BCAX | BICARA THERAPEUTICS INC | -- | $39,398.40 | 2,565 | BQB42F1 |
| 0.04% | ANNX | ANNEXON INC | -- | $38,832.21 | 6,777 | BMVV9R5 |
| 0.04% | XNCR | XENCOR INC | -- | $38,823.84 | 3,344 | BGCYWN8 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $38,056.20 | 11,193 | BBNBTD2 |
| 0.04% | OMER | OMEROS CORP | -- | $37,283.60 | 3,320 | B4NB858 |
| 0.04% | JANX | JANUX THERAPEUTICS INC | -- | $36,805.12 | 2,816 | BMFX8Y7 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $36,621.20 | 2,296 | BQS7491 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $35,268.30 | 2,367 | BD06CS0 |
| 0.04% | BIOA | BIOAGE LABS INC | -- | $34,805.67 | 1,679 | BT9K6D8 |
| 0.04% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $34,733.52 | 7,617 | B3MZ6K5 |
| 0.04% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $34,579.20 | 9,005 | BZ0QMB7 |
| 0.04% | CGEM | CULLINAN THERAPEUTICS INC | -- | $33,828.18 | 2,766 | BM90J52 |
| 0.04% | PSNL | PERSONALIS INC | -- | $33,492.69 | 4,158 | BJQ0608 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $32,994.00 | 1,833 | BD9GVY0 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $31,899.42 | 4,074 | BYZD465 |
| 0.03% | PRME | PRIME MEDICINE INC | -- | $30,173.64 | 8,452 | BPBJFM7 |
| 0.03% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $29,027.50 | 850 | BQD3J33 |
| 0.03% | REPL | REPLIMUNE GROUP INC | -- | $28,465.75 | 3,673 | BDDVW37 |
| 0.03% | CRMD | CORMEDIX INC | -- | $28,368.41 | 3,689 | BJ0LT31 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $28,003.67 | 3,769 | BFYQFJ2 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $27,390.09 | 2,667 | BMFK3H6 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $27,310.28 | 4,412 | BMC3HS7 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $25,727.52 | 14,136 | B4N8MH9 |
| 0.03% | KROS | KEROS THERAPEUTICS INC | -- | $25,054.82 | 1,426 | BM7V485 |
| 0.03% | FULC | FULCRUM THERAPEUTICS INC | -- | $24,681.16 | 2,534 | BJDX8Z9 |
| 0.03% | GOSS | GOSSAMER BIO INC | -- | $24,491.62 | 10,837 | BJ0CK86 |
| 0.03% | RGNX | REGENXBIO INC | -- | $24,482.10 | 2,370 | BZ0G875 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $24,465.72 | 3,417 | BQ6C357 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $24,048.25 | 2,675 | BKLXFX5 |
| 0.03% | ALT | ALTIMMUNE INC | -- | $23,794.82 | 4,886 | BFY7DC4 |
| 0.03% | SLDB | SOLID BIOSCIENCES INC | -- | $23,784.96 | 3,648 | BQHN6C7 |
| 0.03% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $23,476.32 | 5,712 | BYVQJ96 |
| 0.02% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $22,669.60 | 2,636 | BLFBZ32 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $22,584.72 | 677 | B292NQ7 |
| 0.02% | LYEL | LYELL IMMUNOPHARMA INC | -- | $22,551.03 | 993 | BTNMG41 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $22,465.10 | 3,353 | 2107437 |
| 0.02% | PRTA | PROTHENA CORP PLC | -- | $22,453.20 | 2,520 | B91XRN2 |
| 0.02% | KMDA | KAMADA LTD | -- | $22,175.21 | 2,701 | B2Q9833 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $21,348.12 | 876 | BPBPCG8 |
| 0.02% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $21,320.60 | 6,790 | BMCWKZ2 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $20,946.19 | 2,767 | B12W3P6 |
| 0.02% | LENZ | LENZ THERAPEUTICS INC | -- | $20,832.30 | 1,465 | BQV0J03 |
| 0.02% | IVVD | INVIVYD INC | -- | $20,630.25 | 12,975 | BM8NHS1 |
| 0.02% | ABSI | ABSCI CORP | -- | $18,975.50 | 7,041 | BN94K69 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $18,974.00 | 1,790 | BP81RK8 |
| 0.02% | ETON | ETON PHARMACEUTICALS INC | -- | $18,538.56 | 1,256 | BGL0JK3 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $18,252.01 | 1,351 | B9L5200 |
| 0.02% | ACRS | ACLARIS THERAPEUTICS INC | -- | $18,110.61 | 5,073 | BYV2W40 |
| 0.02% | NBP | NOVABRIDGE BIOSCIENCES | -- | $18,011.60 | 4,868 | BKRRKY7 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $17,782.18 | 10,522 | BFZNYB7 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $17,150.30 | 4,183 | BYTYP72 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $16,648.80 | 2,973 | BP81R42 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $16,584.76 | 7,823 | BN4JN37 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $16,371.46 | 2,359 | B7F2TY6 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $16,264.43 | 2,051 | BSMLR16 |
| 0.02% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $16,230.00 | 1,082 | BPRBTY7 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $15,989.60 | 5,060 | BDFKQ07 |
| 0.02% | AVIR | ATEA PHARMACEUTICALS INC | -- | $15,180.70 | 3,658 | BLN9Z50 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $15,040.64 | 2,648 | BMF7DT9 |
| 0.02% | CADL | CANDEL THERAPEUTICS INC | -- | $14,983.10 | 2,570 | BP0TQC5 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $14,903.39 | 3,023 | BMVBZF5 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $14,761.14 | 4,701 | BZC0D70 |
| 0.02% | PEPG | PEPGEN INC | -- | $14,421.12 | 3,219 | BMTX3D7 |
| 0.02% | EOLS | EVOLUS INC | -- | $13,657.50 | 3,035 | BDRJH21 |
| 0.01% | LRMR | LARIMAR THERAPEUTICS INC | -- | $13,506.96 | 4,008 | BMXNGZ6 |
| 0.01% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $13,336.64 | 9,392 | BFMLGR4 |
| 0.01% | LFCR | LIFECORE BIOMEDICAL INC | -- | $13,277.78 | 1,754 | 2517058 |
| 0.01% | AARD | AARDVARK THERAPEUTICS INC | -- | $12,890.35 | 1,019 | BTXQTX3 |
| 0.01% | NGNE | NEUROGENE INC | -- | $12,491.75 | 725 | BS2F741 |
| 0.01% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $12,259.56 | 2,166 | BKDQKM6 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $12,110.26 | 5,659 | BRK0149 |
| 0.01% | OABI | OMNIAB INC | -- | $11,458.00 | 6,740 | BN13S71 |
| 0.01% | CABA | CABALETTA BIO INC | -- | $11,312.57 | 4,507 | BK5MWR1 |
| 0.01% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $10,445.25 | 2,199 | BL5B6Z1 |
| 0.01% | VOR | VOR BIOPHARMA INC | -- | $10,383.24 | 789 | BRJJYT3 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $10,338.04 | 2,644 | BPRB2N7 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $10,153.12 | 2,759 | BY7RB53 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $10,068.10 | 1,330 | BKC9SX3 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $9,751.14 | 9,156 | BNR5QT9 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $8,319.22 | 4,571 | BZ8FPH3 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $8,259.16 | 4,538 | BKX9NQ0 |
| 0.01% | HUMA | HUMACYTE INC | -- | $8,227.01 | 8,768 | BMYTJP4 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $8,058.60 | 1,452 | BP2NYN2 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $6,870.32 | 4,376 | BNYJR68 |
| 0.01% | MENS | JYONG BIOTECH LTD | -- | $6,657.20 | 3,560 | BPTK6Z2 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $6,326.45 | 7,796 | BNNXX52 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $6,016.34 | 2,668 | BKTV702 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $5,638.50 | 2,506 | BP7L561 |
| 0.01% | CDXS | CODEXIS INC | -- | $5,624.57 | 4,229 | B5LL2C2 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $5,571.74 | 4,567 | BNNXX18 |
| -- | PYXS | PYXIS ONCOLOGY INC | -- | $4,401.65 | 2,915 | BLBR8D5 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $15.52 | 01 | BTFHQP5 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 40.83% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 37,138,036 | -- | 6,210 | -- |
| 29.03% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 26,403,289 | -- | 4,415 | -- |
| 23.30% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 21,188,415 | -- | 3,543 | -- |
| 17.35% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 15,782,170 | -- | 2,639 | -- |
| 16.33% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,855,214 | -- | 2,484 | -- |
| 4.16% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,785,568 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $28,240,599.46 | 28,240,599 | -- |
Index
as of 12/31/2025
- Total Number of Companies262
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$7.32 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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