BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 12/31/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 1/16/2026- NAV $80.82
- NAV Change $-0.05
- Market Price $80.83
- Market Price Change $+0.02
- Trading Volume (M) 8,130
- 30-Day Median Bid Ask Spread 0.26%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 1/16/2026- NAV $80.82
- NAV Change $-0.05
- Market Price $80.83
- Market Price Change $+0.02
- Trading Volume (M) 8,130
- 30-Day Median Bid Ask Spread 0.26%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 12/31/2025
Holdings
as of 1/16/2026
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 6.03% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,169,208.32 | 11,712 | 2931034 |
| 5.88% | GILD | GILEAD SCIENCES INC | -- | $5,040,867.96 | 40,356 | 2369174 |
| 5.67% | AMGN | AMGEN INC | -- | $4,857,027.00 | 14,700 | 2023607 |
| 4.13% | REGN | REGENERON PHARMACEUTICALS | -- | $3,535,451.92 | 4,823 | 2730190 |
| 2.59% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,218,492.25 | 6,175 | B00FWN1 |
| 1.88% | INSM | INSMED INC | -- | $1,607,743.20 | 9,960 | 2614487 |
| 1.31% | BIIB | BIOGEN INC | -- | $1,126,441.42 | 6,851 | 2455965 |
| 1.27% | ARGX | ARGENX SE - ADR | -- | $1,087,213.59 | 1,359 | BDVLM39 |
| 1.27% | RVMD | REVOLUTION MEDICINES INC | -- | $1,085,887.84 | 9,028 | BL71K91 |
| 1.18% | ILMN | ILLUMINA INC | -- | $1,010,814.40 | 7,136 | 2613990 |
| 1.14% | INCY | INCYTE CORP | -- | $973,733.28 | 9,168 | 2471950 |
| 1.09% | UTHR | UNITED THERAPEUTICS CORP | -- | $934,974.23 | 2,011 | 2430412 |
| 0.94% | MEDP | MEDPACE HOLDINGS INC | -- | $804,555.30 | 1,317 | BDCBC61 |
| 0.92% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $788,982.95 | 19,949 | BMVP7Y0 |
| 0.89% | MRNA | MODERNA INC | -- | $763,146.52 | 18,244 | BGSXTS3 |
| 0.88% | ROIV | ROIVANT SCIENCES LTD | -- | $751,401.18 | 32,486 | BMW4NZ9 |
| 0.81% | VTRS | VIATRIS INC | -- | $691,687.96 | 53,786 | BMWS3X9 |
| 0.80% | BBIO | BRIDGEBIO PHARMA INC | -- | $686,263.74 | 8,999 | BK1KWG8 |
| 0.79% | GH | GUARDANT HEALTH INC | -- | $677,549.88 | 6,042 | BFXC911 |
| 0.72% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $616,407.84 | 4,656 | 2623911 |
| 0.69% | SMMT | SUMMIT THERAPEUTICS INC | -- | $592,395.60 | 34,765 | BMTVQS7 |
| 0.69% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $590,114.61 | 2,867 | BV9G6B8 |
| 0.67% | IONS | IONIS PHARMACEUTICALS INC | -- | $577,360.12 | 7,564 | BDJ0LS6 |
| 0.67% | SNY | SANOFI-ADR | -- | $575,759.22 | 12,358 | 2964557 |
| 0.66% | TEM | TEMPUS AI INC | -- | $567,774.09 | 8,073 | BSLSJJ0 |
| 0.64% | EXEL | EXELIXIS INC | -- | $550,511.08 | 12,523 | 2576941 |
| 0.62% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $532,784.16 | 1,062 | BD59BS7 |
| 0.60% | BNTX | BIONTECH SE-ADR | -- | $514,589.00 | 4,721 | BK6H543 |
| 0.60% | RNA | AVIDITY BIOSCIENCES INC | -- | $510,180.36 | 7,036 | BMWHPY1 |
| 0.58% | ONC | BEONE MEDICINES LTD-ADR | -- | $497,139.30 | 1,470 | BYYWPW6 |
| 0.57% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $489,781.48 | 8,972 | 2437071 |
| 0.56% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $480,785.58 | 2,838 | B4Q5ZN4 |
| 0.49% | AXSM | AXSOME THERAPEUTICS INC | -- | $417,293.58 | 2,354 | BYZR4X4 |
| 0.47% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $404,490.24 | 6,336 | BYQBFJ8 |
| 0.46% | HALO | HALOZYME THERAPEUTICS INC | -- | $391,085.32 | 5,492 | 2975098 |
| 0.45% | KRYS | KRYSTAL BIOTECH INC | -- | $385,944.16 | 1,354 | BD6JX35 |
| 0.43% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $370,548.00 | 1,168 | BQ721R4 |
| 0.42% | CYTK | CYTOKINETICS INC | -- | $357,331.80 | 5,710 | BBBSBJ5 |
| 0.41% | CAI | CARIS LIFE SCIENCES INC | -- | $352,853.28 | 13,176 | BT18HP9 |
| 0.41% | NUVL | NUVALENT INC-A | -- | $351,773.24 | 3,374 | BMVBZD3 |
| 0.38% | ABVX | ABIVAX SA-ADR | -- | $322,727.60 | 2,756 | BLC89B2 |
| 0.37% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $316,679.08 | 3,116 | BF2YWG4 |
| 0.33% | PCVX | VAXCYTE INC | -- | $284,804.67 | 6,113 | BKPVGH6 |
| 0.33% | COGT | COGENT BIOSCIENCES INC | -- | $279,238.74 | 7,171 | BLR6XK8 |
| 0.32% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $276,556.80 | 3,120 | BQS9486 |
| 0.32% | PTCT | PTC THERAPEUTICS INC | -- | $271,727.52 | 3,749 | B17VCN9 |
| 0.30% | IBRX | IMMUNITYBIO INC | -- | $253,903.44 | 45,997 | BNSP0B8 |
| 0.29% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $248,203.67 | 4,433 | BDD19F8 |
| 0.28% | ALKS | ALKERMES PLC | -- | $243,898.93 | 7,711 | B3P6D26 |
| 0.28% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $239,328.81 | 2,919 | BDCBCD8 |
| 0.28% | CRSP | CRISPR THERAPEUTICS AG | -- | $238,387.05 | 4,455 | BDHF4K6 |
| 0.27% | KYMR | KYMERA THERAPEUTICS INC | -- | $233,654.40 | 3,360 | BMPRZV5 |
| 0.26% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $218,520.00 | 2,400 | BJDX8Y8 |
| 0.25% | IMVT | IMMUNOVANT INC | -- | $215,098.76 | 8,188 | BJRFSB7 |
| 0.25% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $214,327.02 | 4,766 | BFZQ0L8 |
| 0.24% | APGE | APOGEE THERAPEUTICS INC | -- | $206,851.97 | 2,561 | BM9HHL5 |
| 0.24% | FOLD | AMICUS THERAPEUTICS INC | -- | $206,466.64 | 14,408 | B19FQ48 |
| 0.24% | CGON | CG ONCOLOGY INC | -- | $206,167.91 | 3,767 | BRBCSP4 |
| 0.24% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $205,346.99 | 7,901 | 2713317 |
| 0.23% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $196,858.80 | 14,680 | BFNF1D6 |
| 0.22% | ADMA | ADMA BIOLOGICS INC | -- | $192,383.34 | 11,114 | B9NSBM2 |
| 0.22% | INDV | INDIVIOR PLC | -- | $189,773.28 | 5,832 | BP0BQQ5 |
| 0.22% | ACLX | ARCELLX INC | -- | $186,138.00 | 2,700 | BPCJ1Q2 |
| 0.21% | LGND | LIGAND PHARMACEUTICALS | -- | $177,339.43 | 919 | 2501578 |
| 0.21% | GRAL | GRAIL INC | -- | $175,994.00 | 1,820 | BSLSSX7 |
| 0.20% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $167,586.75 | 5,295 | BP8JSP4 |
| 0.18% | TERN | TERNS PHARMACEUTICALS INC | -- | $153,976.20 | 4,207 | BMDJ0C9 |
| 0.18% | VCYT | VERACYTE INC | -- | $153,476.44 | 3,692 | BFTWZY0 |
| 0.17% | BEAM | BEAM THERAPEUTICS INC | -- | $147,951.58 | 4,739 | BK6L288 |
| 0.17% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $147,862.00 | 5,720 | BKX9VD3 |
| 0.17% | IDYA | IDEAYA BIOSCIENCES INC | -- | $146,728.96 | 4,094 | BK0VHF6 |
| 0.17% | XENE | XENON PHARMACEUTICALS INC | -- | $144,327.80 | 3,610 | BRJ3GY4 |
| 0.16% | TARS | TARSUS PHARMACEUTICALS INC | -- | $140,999.48 | 1,982 | BMH5RL1 |
| 0.16% | VERA | VERA THERAPEUTICS INC | -- | $138,832.35 | 2,985 | BL55460 |
| 0.16% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $135,416.16 | 4,944 | BKY5JZ8 |
| 0.16% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $133,900.00 | 2,678 | B72ZBG4 |
| 0.15% | ERAS | ERASCA INC | -- | $127,455.38 | 13,249 | BNLYBF3 |
| 0.15% | IRON | DISC MEDICINE INC | -- | $125,120.52 | 1,764 | BMGJZJ8 |
| 0.15% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $124,830.00 | 7,125 | BJ5FZ74 |
| 0.14% | DNLI | DENALI THERAPEUTICS INC | -- | $123,213.51 | 6,849 | BD2B4V0 |
| 0.14% | MLYS | MINERALYS THERAPEUTICS INC | -- | $121,007.04 | 3,696 | BP9N0G0 |
| 0.14% | SYRE | SPYRE THERAPEUTICS INC | -- | $120,428.52 | 3,623 | BQBBDY8 |
| 0.14% | TWST | TWIST BIOSCIENCE CORP | -- | $118,266.96 | 2,856 | BGKG6G7 |
| 0.14% | APLS | APELLIS PHARMACEUTICALS INC | -- | $117,825.46 | 5,909 | BYTQ6X1 |
| 0.14% | TVTX | TRAVERE THERAPEUTICS INC | -- | $116,440.86 | 4,178 | BLFGJD5 |
| 0.13% | OCUL | OCULAR THERAPEUTIX INC | -- | $112,181.58 | 9,954 | BNZB1X8 |
| 0.13% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $112,136.04 | 24,012 | BM9FJ13 |
| 0.13% | TXG | 10X GENOMICS INC-CLASS A | -- | $111,669.84 | 5,442 | BKS3RS7 |
| 0.13% | DYN | DYNE THERAPEUTICS INC | -- | $111,422.35 | 6,670 | BN15WD1 |
| 0.13% | ALMS | ALUMIS INC | -- | $108,324.40 | 4,540 | BPLQG36 |
| 0.12% | WVE | WAVE LIFE SCIENCES LTD | -- | $106,565.55 | 7,807 | BYZG9R0 |
| 0.12% | SRPT | SAREPTA THERAPEUTICS INC | -- | $103,389.09 | 4,893 | B8DPDT7 |
| 0.12% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $101,317.45 | 4,505 | BJ62Z18 |
| 0.12% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $100,011.00 | 4,505 | BLB0YQ9 |
| 0.12% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $99,630.94 | 3,671 | BMZ4LN0 |
| 0.11% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $97,431.80 | 2,690 | BKSGZN7 |
| 0.11% | MAZE | MAZE THERAPEUTICS INC | -- | $91,610.19 | 2,247 | BSRK699 |
| 0.11% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $91,609.65 | 6,169 | BFWLC09 |
| 0.11% | NRIX | NURIX THERAPEUTICS INC | -- | $90,940.14 | 4,734 | BMVLGP2 |
| 0.10% | ANIP | ANI PHARMACEUTICALS INC | -- | $88,986.67 | 1,049 | BCDWBX6 |
| 0.10% | VCEL | VERICEL CORP | -- | $88,338.80 | 2,362 | BSBMN89 |
| 0.10% | GMAB | GENMAB A/S -SP ADR | -- | $88,042.50 | 2,730 | BBC9WC7 |
| 0.10% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $87,054.48 | 3,932 | BMX9K07 |
| 0.10% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $85,714.92 | 5,484 | BRJZSK0 |
| 0.10% | MBX | MBX BIOSCIENCES INC | -- | $84,991.41 | 2,097 | BQXJKH2 |
| 0.10% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $83,290.68 | 4,059 | BN7Q7R7 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $83,115.69 | 2,109 | BRXB0C0 |
| 0.10% | HROW | HARROW INC | -- | $82,867.00 | 1,730 | BHNDW86 |
| 0.10% | ZYME | ZYMEWORKS INC | -- | $82,027.65 | 3,495 | BPCQZY9 |
| 0.10% | TNGX | TANGO THERAPEUTICS INC | -- | $81,819.89 | 6,289 | BP2P6L0 |
| 0.10% | SION | SIONNA THERAPEUTICS INC | -- | $81,505.24 | 2,084 | BQKXDX4 |
| 0.09% | UPB | UPSTREAM BIO INC | -- | $78,244.00 | 2,524 | BRCFFK6 |
| 0.09% | ARDX | ARDELYX INC | -- | $76,592.25 | 11,347 | BN89V40 |
| 0.09% | STOK | STOKE THERAPEUTICS INC | -- | $76,542.90 | 2,667 | BJQ05Z6 |
| 0.09% | ORKA | ORUKA THERAPEUTICS INC | -- | $75,517.40 | 2,261 | BKVF0J2 |
| 0.09% | PHVS | PHARVARIS NV | -- | $75,044.19 | 2,991 | BMZ2X38 |
| 0.09% | MNKD | MANNKIND CORP | -- | $74,784.34 | 14,354 | BF081J4 |
| 0.09% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $74,038.37 | 2,723 | BCBVTX1 |
| 0.09% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $74,013.41 | 2,771 | BMFD115 |
| 0.09% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $73,330.40 | 5,128 | BPCK358 |
| 0.09% | PGEN | PRECIGEN INC | -- | $73,034.01 | 16,561 | BKM5C84 |
| 0.08% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $72,102.11 | 3,041 | BP7KZP7 |
| 0.08% | ALVO | ALVOTECH SA | -- | $71,920.56 | 14,618 | BPNTJ34 |
| 0.08% | TYRA | TYRA BIOSCIENCES INC | -- | $71,694.84 | 2,492 | BMVNDH9 |
| 0.08% | NVCR | NOVOCURE LTD | -- | $71,323.56 | 5,229 | BYSS4X4 |
| 0.08% | FTRE | FORTREA HOLDINGS INC | -- | $71,197.50 | 4,315 | BRXYZ57 |
| 0.08% | -- | DEFINIUM THERAPEUTICS INC COMMON STOCK USD 0 | -- | $69,230.00 | 4,600 | -- |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $67,933.95 | 2,037 | BLCD809 |
| 0.08% | INVA | INNOVIVA INC | -- | $67,884.48 | 3,492 | BDDXF67 |
| 0.08% | NTLA | INTELLIA THERAPEUTICS INC | -- | $67,662.50 | 5,413 | BYZM6C2 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $67,305.60 | 1,476 | BX7RSN3 |
| 0.08% | KOD | KODIAK SCIENCES INC | -- | $67,250.55 | 2,477 | BFXC933 |
| 0.08% | QURE | UNIQURE NV | -- | $66,441.56 | 2,909 | BJFSR88 |
| 0.08% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $65,481.12 | 9,832 | 2100362 |
| 0.07% | TRVI | TREVI THERAPEUTICS INC | -- | $62,754.24 | 5,988 | BJH9ZN0 |
| 0.07% | ATAI | ATAIBECKLEY INC | -- | $61,738.04 | 16,961 | BWJDYK1 |
| 0.07% | NVAX | NOVAVAX INC | -- | $60,787.89 | 7,589 | BJDQXG4 |
| 0.07% | RAPP | RAPPORT THERAPEUTICS INC | -- | $59,598.63 | 2,223 | BR3T9B6 |
| 0.07% | RLAY | RELAY THERAPEUTICS INC | -- | $59,527.65 | 8,099 | BN2R582 |
| 0.07% | ANAB | ANAPTYSBIO INC | -- | $59,064.24 | 1,293 | BDRW1L7 |
| 0.07% | EYPT | EYEPOINT INC | -- | $58,374.68 | 3,871 | BMGS7L1 |
| 0.07% | TSHA | TAYSHA GENE THERAPIES INC | -- | $58,331.52 | 12,792 | BNC1BX1 |
| 0.07% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $58,264.96 | 7,748 | BLR7H87 |
| 0.07% | ABCL | ABCELLERA BIOLOGICS INC | -- | $57,593.48 | 13,979 | BL53SR3 |
| 0.07% | SANA | SANA BIOTECHNOLOGY INC | -- | $56,970.62 | 12,439 | BMFJJ97 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $55,946.22 | 2,146 | BNFWZS4 |
| 0.06% | SVRA | SAVARA INC | -- | $55,301.64 | 9,502 | BYXGN81 |
| 0.06% | ORIC | ORIC PHARMACEUTICALS INC | -- | $55,121.76 | 4,548 | BKVDFF7 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $54,533.63 | 1,363 | BKLCWZ3 |
| 0.06% | SEPN | SEPTERNA INC | -- | $54,512.37 | 2,091 | BQNKXX2 |
| 0.06% | ZBIO | ZENAS BIOPHARMA INC | -- | $50,662.08 | 2,513 | BQB42H3 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $50,646.33 | 5,697 | B8K7T65 |
| 0.06% | GHRS | GH RESEARCH PLC | -- | $49,220.03 | 2,897 | BP6C0S2 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $49,071.33 | 679 | BNSP8K3 |
| 0.06% | SPRY | ARS PHARMACEUTICALS INC | -- | $49,068.08 | 4,616 | BMCR7V2 |
| 0.06% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $48,717.20 | 4,795 | BLB0YH0 |
| 0.06% | TBPH | THERAVANCE BIOPHARMA INC | -- | $47,343.66 | 2,366 | BMNDK09 |
| 0.05% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $46,805.74 | 3,329 | BJLKVS6 |
| 0.05% | VTYX | VENTYX BIOSCIENCES INC | -- | $46,281.48 | 3,332 | BMG99Y1 |
| 0.05% | RAPT | RAPT THERAPEUTICS INC | -- | $45,419.40 | 1,294 | BTJZB49 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $43,938.48 | 18,618 | BF0DMK7 |
| 0.05% | BCAX | BICARA THERAPEUTICS INC | -- | $42,880.00 | 2,560 | BQB42F1 |
| 0.05% | CTMX | CYTOMX THERAPEUTICS INC | -- | $42,726.53 | 7,927 | BYWVTY5 |
| 0.05% | XNCR | XENCOR INC | -- | $42,654.65 | 3,335 | BGCYWN8 |
| 0.05% | ANNX | ANNEXON INC | -- | $41,124.25 | 6,775 | BMVV9R5 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $41,096.80 | 2,186 | BZ7PJQ1 |
| 0.05% | PSNL | PERSONALIS INC | -- | $41,013.83 | 4,147 | BJQ0608 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $40,218.08 | 1,928 | BMGTLY5 |
| 0.05% | MESO | MESOBLAST LTD- SPON ADR | -- | $39,960.50 | 2,290 | BQS7491 |
| 0.05% | OMER | OMEROS CORP | -- | $39,765.11 | 3,311 | B4NB858 |
| 0.05% | VIR | VIR BIOTECHNOLOGY INC | -- | $39,371.82 | 6,497 | BK4PZ38 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $39,221.85 | 955 | BL95N25 |
| 0.05% | GERN | GERON CORP | -- | $39,051.10 | 29,810 | 2370381 |
| 0.05% | JANX | JANUX THERAPEUTICS INC | -- | $38,651.84 | 2,809 | BMFX8Y7 |
| 0.04% | PCRX | PACIRA BIOSCIENCES INC | -- | $38,492.44 | 2,009 | B3X26D8 |
| 0.04% | ARVN | ARVINAS INC | -- | $36,587.80 | 2,999 | BDZ30Q0 |
| 0.04% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $36,552.18 | 9,003 | BZ0QMB7 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $34,485.20 | 2,362 | BD06CS0 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $34,381.44 | 4,064 | BYZD465 |
| 0.04% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $34,110.00 | 7,580 | B3MZ6K5 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $33,964.24 | 1,828 | BD9GVY0 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $33,938.56 | 11,164 | BBNBTD2 |
| 0.04% | BIOA | BIOAGE LABS INC | -- | $33,747.84 | 1,674 | BT9K6D8 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $33,591.20 | 8,440 | BPBJFM7 |
| 0.04% | CMPS | COMPASS PATHWAYS PLC | -- | $32,340.00 | 4,400 | BMC3HS7 |
| 0.04% | RGNX | REGENXBIO INC | -- | $32,197.68 | 2,364 | BZ0G875 |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $31,783.04 | 848 | BQD3J33 |
| 0.04% | IVVD | INVIVYD INC | -- | $31,705.45 | 12,941 | BM8NHS1 |
| 0.04% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $31,158.79 | 14,099 | B4N8MH9 |
| 0.03% | CGEM | CULLINAN THERAPEUTICS INC | -- | $29,576.48 | 2,759 | BM90J52 |
| 0.03% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $28,078.40 | 3,488 | BYP80F1 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $27,891.78 | 3,759 | BFYQFJ2 |
| 0.03% | GOSS | GOSSAMER BIO INC | -- | $27,291.60 | 10,830 | BJ0CK86 |
| 0.03% | KROS | KEROS THERAPEUTICS INC | -- | $26,837.78 | 1,423 | BM7V485 |
| 0.03% | LENZ | LENZ THERAPEUTICS INC | -- | $26,721.69 | 1,461 | BQV0J03 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $26,546.24 | 6,772 | BMCWKZ2 |
| 0.03% | REPL | REPLIMUNE GROUP INC | -- | $25,787.52 | 3,663 | BDDVW37 |
| 0.03% | FULC | FULCRUM THERAPEUTICS INC | -- | $25,623.78 | 2,527 | BJDX8Z9 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $25,185.12 | 3,408 | BQ6C357 |
| 0.03% | CRMD | CORMEDIX INC | -- | $24,943.62 | 3,679 | BJ0LT31 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $24,684.80 | 2,660 | BMFK3H6 |
| 0.03% | LYEL | LYELL IMMUNOPHARMA INC | -- | $23,546.16 | 991 | BTNMG41 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $23,505.90 | 2,514 | B91XRN2 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $23,476.97 | 2,629 | BLFBZ32 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $22,626.00 | 675 | B292NQ7 |
| 0.03% | KMDA | KAMADA LTD | -- | $22,009.98 | 2,694 | B2Q9833 |
| 0.03% | SIGA | SIGA TECHNOLOGIES INC | -- | $22,003.52 | 3,344 | 2107437 |
| 0.02% | ABSI | ABSCI CORP | -- | $21,206.44 | 7,022 | BN94K69 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $20,926.77 | 4,177 | BYTYP72 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $20,661.52 | 4,873 | BFY7DC4 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $20,617.20 | 2,760 | B12W3P6 |
| 0.02% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $20,143.40 | 2,668 | BKLXFX5 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $19,899.86 | 3,638 | BQHN6C7 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $19,635.00 | 1,785 | BP81RK8 |
| 0.02% | ETON | ETON PHARMACEUTICALS INC | -- | $18,955.28 | 1,252 | BGL0JK3 |
| 0.02% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $18,857.07 | 5,697 | BYVQJ96 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $18,396.56 | 5,054 | BDFKQ07 |
| 0.02% | NBP | NOVABRIDGE BIOSCIENCES | -- | $18,109.15 | 4,855 | BKRRKY7 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $17,106.85 | 10,495 | BFZNYB7 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $17,096.20 | 2,045 | BSMLR16 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $16,998.28 | 1,348 | B9L5200 |
| 0.02% | PEPG | PEPGEN INC | -- | $16,692.00 | 3,210 | BMTX3D7 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $16,458.39 | 4,689 | BZC0D70 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $16,431.20 | 874 | BPBPCG8 |
| 0.02% | CADL | CANDEL THERAPEUTICS INC | -- | $16,409.60 | 2,564 | BP0TQC5 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $15,898.82 | 2,641 | BMF7DT9 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $15,762.06 | 7,803 | BN4JN37 |
| 0.02% | EOLS | EVOLUS INC | -- | $15,740.40 | 3,027 | BDRJH21 |
| 0.02% | AARD | AARDVARK THERAPEUTICS INC | -- | $15,631.29 | 1,017 | BTXQTX3 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $14,988.61 | 2,353 | B7F2TY6 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $14,889.32 | 2,966 | BP81R42 |
| 0.02% | LFCR | LIFECORE BIOMEDICAL INC | -- | $14,385.00 | 1,750 | 2517058 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $14,068.11 | 2,161 | BKDQKM6 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $13,827.02 | 3,019 | BMVBZF5 |
| 0.02% | ACRS | ACLARIS THERAPEUTICS INC | -- | $13,257.20 | 5,060 | BYV2W40 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $12,927.84 | 9,368 | BFMLGR4 |
| 0.01% | OABI | OMNIAB INC | -- | $12,773.70 | 6,723 | BN13S71 |
| 0.01% | NGNE | NEUROGENE INC | -- | $12,688.65 | 723 | BS2F741 |
| 0.01% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $12,667.46 | 1,079 | BPRBTY7 |
| 0.01% | LRMR | LARIMAR THERAPEUTICS INC | -- | $12,510.61 | 3,997 | BMXNGZ6 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $12,403.20 | 3,648 | BLN9Z50 |
| 0.01% | VOR | VOR BIOPHARMA INC | -- | $12,395.25 | 787 | BRJJYT3 |
| 0.01% | MENS | JYONG BIOTECH LTD | -- | $11,821.50 | 3,550 | BPTK6Z2 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $11,597.64 | 9,132 | BNR5QT9 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $11,128.14 | 2,637 | BPRB2N7 |
| 0.01% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $11,052.72 | 2,193 | BL5B6Z1 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $10,362.56 | 2,756 | BY7RB53 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $10,092.98 | 4,526 | BKX9NQ0 |
| 0.01% | CABA | CABALETTA BIO INC | -- | $9,889.00 | 4,495 | BK5MWR1 |
| 0.01% | HUMA | HUMACYTE INC | -- | $9,706.95 | 8,745 | BMYTJP4 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $9,673.83 | 1,327 | BKC9SX3 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $9,254.77 | 4,559 | BZ8FPH3 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $9,032.00 | 5,645 | BRK0149 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $8,903.00 | 1,450 | BP2NYN2 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $8,300.00 | 2,500 | BP7L561 |
| 0.01% | CDXS | CODEXIS INC | -- | $7,044.06 | 4,218 | B5LL2C2 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $6,812.16 | 2,661 | BKTV702 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $6,372.90 | 4,365 | BNYJR68 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $6,331.45 | 4,555 | BNNXX18 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $5,672.59 | 7,776 | BNNXX52 |
| 0.01% | PYXS | PYXIS ONCOLOGY INC | -- | $5,118.08 | 2,908 | BLBR8D5 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $13.82 | 01 | BTFHQP5 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| 38.96% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 33,375,665 | -- | 5,795 | -- |
| 30.46% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 26,095,796 | -- | 4,531 | -- |
| 24.05% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 20,601,338 | -- | 3,577 | -- |
| 16.70% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,306,325 | -- | 2,484 | -- |
| 15.46% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 13,240,838 | -- | 2,299 | -- |
| 4.26% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,645,694 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $25,425,123.37 | 25,425,123 | -- |
Index
as of 12/31/2025
- Total Number of Companies262
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$7.32 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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