BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 1/31/2026
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 4.27% | 16.53% | 65.39% | 4.27% | 51.38% | 11.58% | -2.47% | 6.91% | 16.64% | 04/07/2010 |
| BIB Market Price | 4.19% | 16.41% | 65.44% | 4.19% | 51.07% | 11.50% | -2.49% | 6.94% | 16.64% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 3/03/2026- NAV $83.30
- NAV Change $-4.01
- Market Price $83.33
- Market Price Change $-3.99
- Trading Volume (M) 19,822
- 30-Day Median Bid Ask Spread 0.26%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 3/03/2026- NAV $83.30
- NAV Change $-4.01
- Market Price $83.33
- Market Price Change $-3.99
- Trading Volume (M) 19,822
- 30-Day Median Bid Ask Spread 0.26%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 12/31/2025
Holdings
as of 3/03/2026
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 6.81% | GILD | GILEAD SCIENCES INC | -- | $5,899,008.32 | 39,904 | 2369174 |
| 6.34% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,492,520.87 | 11,581 | 2931034 |
| 6.33% | AMGN | AMGEN INC | -- | $5,480,072.00 | 14,536 | 2023607 |
| 4.22% | REGN | REGENERON PHARMACEUTICALS | -- | $3,656,201.54 | 4,769 | 2730190 |
| 2.24% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $1,944,083.65 | 6,101 | B00FWN1 |
| 1.67% | INSM | INSMED INC | -- | $1,447,656.00 | 9,848 | 2614487 |
| 1.44% | BIIB | BIOGEN INC | -- | $1,246,551.48 | 6,774 | 2455965 |
| 1.16% | ARGX | ARGENX SE - ADR | -- | $1,006,279.68 | 1,344 | BDVLM39 |
| 1.14% | UTHR | UNITED THERAPEUTICS CORP | -- | $991,316.20 | 1,988 | 2430412 |
| 1.08% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $936,732.92 | 19,729 | BMVP7Y0 |
| 1.06% | ILMN | ILLUMINA INC | -- | $914,045.80 | 7,055 | 2613990 |
| 1.04% | MRNA | MODERNA INC | -- | $898,883.37 | 18,039 | BGSXTS3 |
| 1.04% | RVMD | REVOLUTION MEDICINES INC | -- | $897,074.23 | 8,927 | BL71K91 |
| 1.03% | ROIV | ROIVANT SCIENCES LTD | -- | $894,374.90 | 32,114 | BMW4NZ9 |
| 1.03% | INCY | INCYTE CORP | -- | $889,004.55 | 9,065 | 2471950 |
| 0.91% | VTRS | VIATRIS INC | -- | $791,894.87 | 53,183 | BMWS3X9 |
| 0.78% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $678,188.70 | 2,835 | BV9G6B8 |
| 0.70% | MEDP | MEDPACE HOLDINGS INC | -- | $605,459.38 | 1,301 | BDCBC61 |
| 0.70% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $603,768.56 | 4,604 | 2623911 |
| 0.68% | IONS | IONIS PHARMACEUTICALS INC | -- | $588,298.14 | 7,479 | BDJ0LS6 |
| 0.66% | BBIO | BRIDGEBIO PHARMA INC | -- | $574,123.41 | 8,897 | BK1KWG8 |
| 0.66% | SNY | SANOFI-ADR | -- | $567,816.93 | 12,219 | 2964557 |
| 0.64% | GH | GUARDANT HEALTH INC | -- | $557,374.20 | 5,974 | BFXC911 |
| 0.60% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $523,796.02 | 2,806 | B4Q5ZN4 |
| 0.60% | SMMT | SUMMIT THERAPEUTICS INC | -- | $519,406.25 | 34,375 | BMTVQS7 |
| 0.60% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $519,219.63 | 8,871 | 2437071 |
| 0.58% | EXEL | EXELIXIS INC | -- | $504,401.94 | 12,381 | 2576941 |
| 0.54% | BNTX | BIONTECH SE-ADR | -- | $470,448.44 | 4,669 | BK6H543 |
| 0.52% | IBRX | IMMUNITYBIO INC | -- | $454,810.00 | 45,481 | BNSP0B8 |
| 0.52% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $446,290.80 | 1,048 | BD59BS7 |
| 0.50% | ONC | BEONE MEDICINES LTD-ADR | -- | $431,896.16 | 1,454 | BYYWPW6 |
| 0.47% | TEM | TEMPUS AI INC-CL A | -- | $410,274.80 | 7,982 | BSLSJJ0 |
| 0.46% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $401,971.10 | 6,271 | BYQBFJ8 |
| 0.44% | AXSM | AXSOME THERAPEUTICS INC | -- | $381,744.35 | 2,327 | BYZR4X4 |
| 0.43% | HALO | HALOZYME THERAPEUTICS INC | -- | $376,842.00 | 5,430 | 2975098 |
| 0.42% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $367,544.10 | 1,155 | BQ721R4 |
| 0.42% | PCVX | VAXCYTE INC | -- | $361,552.08 | 6,044 | BKPVGH6 |
| 0.41% | KRYS | KRYSTAL BIOTECH INC | -- | $353,228.20 | 1,339 | BD6JX35 |
| 0.40% | CYTK | CYTOKINETICS INC | -- | $342,825.12 | 5,646 | BBBSBJ5 |
| 0.39% | NUVL | NUVALENT INC-A | -- | $334,233.70 | 3,335 | BMVBZD3 |
| 0.35% | ACLX | ARCELLX INC | -- | $304,513.50 | 2,670 | BPCJ1Q2 |
| 0.35% | ABVX | ABIVAX SA-ADR | -- | $302,858.60 | 2,726 | BLC89B2 |
| 0.33% | KYMR | KYMERA THERAPEUTICS INC | -- | $286,854.70 | 3,322 | BMPRZV5 |
| 0.32% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $276,023.92 | 3,082 | BF2YWG4 |
| 0.30% | COGT | COGENT BIOSCIENCES INC | -- | $263,957.12 | 7,088 | BLR6XK8 |
| 0.30% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $263,583.10 | 2,887 | BDCBCD8 |
| 0.29% | CRSP | CRISPR THERAPEUTICS AG | -- | $255,464.00 | 4,400 | BDHF4K6 |
| 0.29% | CAI | CARIS LIFE SCIENCES INC | -- | $252,502.02 | 13,029 | BT18HP9 |
| 0.28% | PTCT | PTC THERAPEUTICS INC | -- | $238,693.73 | 3,707 | B17VCN9 |
| 0.26% | CGON | CG ONCOLOGY INC | -- | $225,548.75 | 3,725 | BRBCSP4 |
| 0.26% | ALKS | ALKERMES PLC | -- | $222,620.80 | 7,624 | B3P6D26 |
| 0.25% | IMVT | IMMUNOVANT INC | -- | $216,190.74 | 8,094 | BJRFSB7 |
| 0.24% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $208,700.10 | 4,710 | BFZQ0L8 |
| 0.24% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $208,349.40 | 2,373 | BJDX8Y8 |
| 0.24% | FOLD | AMICUS THERAPEUTICS INC | -- | $204,301.98 | 14,247 | B19FQ48 |
| 0.22% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $194,526.01 | 3,086 | BQS9486 |
| 0.22% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $193,207.96 | 14,516 | BFNF1D6 |
| 0.21% | LGND | LIGAND PHARMACEUTICALS | -- | $185,654.16 | 909 | 2501578 |
| 0.21% | ERAS | ERASCA INC | -- | $184,724.10 | 13,101 | BNLYBF3 |
| 0.21% | ADMA | ADMA BIOLOGICS INC | -- | $180,016.20 | 10,990 | B9NSBM2 |
| 0.21% | INDV | INDIVIOR PHARMACEUTICALS INC | -- | $177,903.81 | 5,763 | BTZRLN8 |
| 0.20% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $175,805.84 | 4,382 | BDD19F8 |
| 0.20% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $175,770.00 | 7,812 | 2713317 |
| 0.20% | APGE | APOGEE THERAPEUTICS INC | -- | $173,442.00 | 2,532 | BM9HHL5 |
| 0.20% | TERN | TERNS PHARMACEUTICALS INC | -- | $172,681.60 | 4,160 | BMDJ0C9 |
| 0.18% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $159,200.58 | 5,236 | BP8JSP4 |
| 0.18% | XENE | XENON PHARMACEUTICALS INC | -- | $156,242.72 | 3,568 | BRJ3GY4 |
| 0.17% | TARS | TARSUS PHARMACEUTICALS INC | -- | $150,114.55 | 1,961 | BMH5RL1 |
| 0.17% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $144,474.88 | 2,648 | B72ZBG4 |
| 0.17% | SYRE | SPYRE THERAPEUTICS INC | -- | $143,570.81 | 3,583 | BQBBDY8 |
| 0.16% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $140,852.09 | 4,889 | BKY5JZ8 |
| 0.16% | IDYA | IDEAYA BIOSCIENCES INC | -- | $138,886.88 | 4,048 | BK0VHF6 |
| 0.16% | DNLI | DENALI THERAPEUTICS INC | -- | $135,575.44 | 6,772 | BD2B4V0 |
| 0.15% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $133,481.60 | 5,656 | BKX9VD3 |
| 0.15% | TWST | TWIST BIOSCIENCE CORP | -- | $131,692.95 | 2,823 | BGKG6G7 |
| 0.15% | VCYT | VERACYTE INC | -- | $128,042.00 | 3,650 | BFTWZY0 |
| 0.15% | BEAM | BEAM THERAPEUTICS INC | -- | $127,525.70 | 4,685 | BK6L288 |
| 0.15% | ALMS | ALUMIS INC | -- | $126,365.35 | 4,489 | BPLQG36 |
| 0.14% | TXG | 10X GENOMICS INC-CLASS A | -- | $121,672.98 | 5,379 | BKS3RS7 |
| 0.14% | APLS | APELLIS PHARMACEUTICALS INC | -- | $117,714.24 | 5,839 | BYTQ6X1 |
| 0.13% | TVTX | TRAVERE THERAPEUTICS INC | -- | $116,783.37 | 4,131 | BLFGJD5 |
| 0.13% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $116,721.00 | 4,455 | BLB0YQ9 |
| 0.13% | VERA | VERA THERAPEUTICS INC | -- | $115,935.00 | 2,950 | BL55460 |
| 0.13% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $113,347.92 | 7,049 | BJ5FZ74 |
| 0.13% | IRON | DISC MEDICINE INC | -- | $112,243.84 | 1,744 | BMGJZJ8 |
| 0.12% | OCUL | OCULAR THERAPEUTIX INC | -- | $105,846.12 | 9,837 | BNZB1X8 |
| 0.12% | MLYS | MINERALYS THERAPEUTICS INC | -- | $104,175.54 | 3,654 | BP9N0G0 |
| 0.12% | WVE | WAVE LIFE SCIENCES LTD | -- | $103,797.12 | 7,723 | BYZG9R0 |
| 0.11% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $98,321.85 | 4,455 | BJ62Z18 |
| 0.11% | MAZE | MAZE THERAPEUTICS INC | -- | $98,167.96 | 2,222 | BSRK699 |
| 0.11% | DYN | DYNE THERAPEUTICS INC | -- | $96,287.00 | 6,595 | BN15WD1 |
| 0.11% | GRAL | GRAIL INC | -- | $94,968.00 | 1,800 | BSLSSX7 |
| 0.11% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $94,641.82 | 2,086 | BRXB0C0 |
| 0.10% | STOK | STOKE THERAPEUTICS INC | -- | $89,111.64 | 2,638 | BJQ05Z6 |
| 0.10% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $86,145.20 | 6,088 | BFWLC09 |
| 0.10% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $85,899.60 | 4,014 | BN7Q7R7 |
| 0.10% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $85,097.76 | 3,632 | BMZ4LN0 |
| 0.10% | ZYME | ZYMEWORKS INC | -- | $84,499.20 | 3,456 | BPCQZY9 |
| 0.10% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $84,484.18 | 9,722 | 2100362 |
| 0.10% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $84,050.22 | 23,743 | BM9FJ13 |
| 0.09% | TYRA | TYRA BIOSCIENCES INC | -- | $81,336.64 | 2,464 | BMVNDH9 |
| 0.09% | DFTX | DEFINIUM THERAPEUTICS INC | -- | $80,454.12 | 4,548 | BV2DHY6 |
| 0.09% | VCEL | VERICEL CORP | -- | $80,300.65 | 2,335 | BSBMN89 |
| 0.09% | PHVS | PHARVARIS NV | -- | $79,200.45 | 2,958 | BMZ2X38 |
| 0.09% | ANIP | ANI PHARMACEUTICALS INC | -- | $78,915.70 | 1,037 | BCDWBX6 |
| 0.09% | RLAY | RELAY THERAPEUTICS INC | -- | $78,829.55 | 8,003 | BN2R582 |
| 0.09% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $78,803.75 | 2,741 | BMFD115 |
| 0.09% | INVA | INNOVIVA INC | -- | $77,001.90 | 3,453 | BDDXF67 |
| 0.09% | SRPT | SAREPTA THERAPEUTICS INC | -- | $76,779.06 | 4,838 | B8DPDT7 |
| 0.09% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $76,668.16 | 2,692 | BCBVTX1 |
| 0.09% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $75,198.20 | 2,660 | BKSGZN7 |
| 0.09% | GMAB | GENMAB A/S -SP ADR | -- | $74,654.34 | 2,699 | BBC9WC7 |
| 0.09% | NRIX | NURIX THERAPEUTICS INC | -- | $73,990.80 | 4,680 | BMVLGP2 |
| 0.08% | ORKA | ORUKA THERAPEUTICS INC | -- | $73,430.24 | 2,236 | BKVF0J2 |
| 0.08% | NTLA | INTELLIA THERAPEUTICS INC | -- | $72,759.54 | 5,348 | BYZM6C2 |
| 0.08% | TRVI | TREVI THERAPEUTICS INC | -- | $72,591.46 | 5,921 | BJH9ZN0 |
| 0.08% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $71,551.81 | 5,071 | BPCK358 |
| 0.08% | TNGX | TANGO THERAPEUTICS INC | -- | $71,518.50 | 6,219 | BP2P6L0 |
| 0.08% | NVAX | NOVAVAX INC | -- | $71,212.96 | 7,504 | BJDQXG4 |
| 0.08% | SION | SIONNA THERAPEUTICS INC | -- | $70,259.49 | 2,061 | BQKXDX4 |
| 0.08% | EYPT | EYEPOINT INC | -- | $70,019.04 | 3,822 | BMGS7L1 |
| 0.08% | ARDX | ARDELYX INC | -- | $69,788.40 | 11,220 | BN89V40 |
| 0.08% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $69,439.68 | 3,888 | BMX9K07 |
| 0.08% | NVCR | NOVOCURE LTD | -- | $68,774.30 | 5,171 | BYSS4X4 |
| 0.08% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $68,645.85 | 18,330 | BF0DMK7 |
| 0.08% | ANAB | ANAPTYSBIO INC | -- | $67,516.74 | 1,278 | BDRW1L7 |
| 0.08% | HROW | HARROW INC | -- | $66,014.55 | 1,710 | BHNDW86 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $65,205.40 | 2,015 | BLCD809 |
| 0.07% | KOD | KODIAK SCIENCES INC | -- | $64,778.00 | 2,450 | BFXC933 |
| 0.07% | MBX | MBX BIOSCIENCES INC | -- | $63,309.42 | 2,073 | BQXJKH2 |
| 0.07% | ZBIO | ZENAS BIOPHARMA INC | -- | $62,396.04 | 2,478 | BQB42H3 |
| 0.07% | ATAI | ATAIBECKLEY INC | -- | $61,881.30 | 16,770 | BWJDYK1 |
| 0.07% | RAPP | RAPPORT THERAPEUTICS INC | -- | $61,297.85 | 2,201 | BR3T9B6 |
| 0.07% | ORIC | ORIC PHARMACEUTICALS INC | -- | $60,754.47 | 4,497 | BKVDFF7 |
| 0.07% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $60,460.97 | 3,449 | BYP80F1 |
| 0.07% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $58,385.40 | 1,460 | BX7RSN3 |
| 0.07% | SEPN | SEPTERNA INC | -- | $58,144.71 | 2,067 | BQNKXX2 |
| 0.07% | TSHA | TAYSHA GENE THERAPIES INC | -- | $57,295.44 | 12,648 | BNC1BX1 |
| 0.07% | VIR | VIR BIOTECHNOLOGY INC | -- | $57,237.84 | 6,424 | BK4PZ38 |
| 0.06% | PGEN | PRECIGEN INC | -- | $55,140.75 | 16,338 | BKM5C84 |
| 0.06% | ALVO | ALVOTECH SA | -- | $54,925.20 | 14,454 | BPNTJ34 |
| 0.06% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $54,005.72 | 3,007 | BP7KZP7 |
| 0.06% | SVRA | SAVARA INC | -- | $52,424.10 | 9,395 | BYXGN81 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $51,279.62 | 13,822 | BL53SR3 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $49,949.76 | 672 | BNSP8K3 |
| 0.06% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $49,333.90 | 946 | BL95N25 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $48,669.12 | 5,633 | B8K7T65 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $48,339.00 | 12,300 | BMFJJ97 |
| 0.05% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $47,552.23 | 4,741 | BLB0YH0 |
| 0.05% | VTYX | VENTYX BIOSCIENCES INC | -- | $46,130.00 | 3,295 | BMG99Y1 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $45,629.64 | 1,906 | BMGTLY5 |
| 0.05% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $45,512.28 | 7,662 | BLR7H87 |
| 0.05% | BCAX | BICARA THERAPEUTICS INC | -- | $45,337.60 | 2,530 | BQB42F1 |
| 0.05% | FTRE | FORTREA HOLDINGS INC | -- | $44,707.68 | 4,266 | BRXYZ57 |
| 0.05% | PCRX | PACIRA BIOSCIENCES INC | -- | $43,890.60 | 1,986 | B3X26D8 |
| 0.05% | GHRS | GH RESEARCH PLC | -- | $43,819.20 | 2,864 | BP6C0S2 |
| 0.05% | CGEM | CULLINAN THERAPEUTICS INC | -- | $42,911.44 | 2,728 | BM90J52 |
| 0.05% | GERN | GERON CORP | -- | $42,445.44 | 29,476 | 2370381 |
| 0.05% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $42,079.26 | 2,122 | BNFWZS4 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $41,651.89 | 8,881 | BZ0QMB7 |
| 0.05% | MNKD | MANNKIND CORP | -- | $41,476.50 | 14,180 | BF081J4 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $40,688.84 | 2,162 | BZ7PJQ1 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $40,482.68 | 4,564 | BMCR7V2 |
| 0.05% | XNCR | XENCOR INC | -- | $39,641.96 | 3,298 | BGCYWN8 |
| 0.05% | ARVN | ARVINAS INC | -- | $39,612.40 | 2,965 | BDZ30Q0 |
| 0.04% | OMER | OMEROS CORP | -- | $38,109.36 | 3,274 | B4NB858 |
| 0.04% | CTMX | CYTOMX THERAPEUTICS INC | -- | $37,628.63 | 7,823 | BYWVTY5 |
| 0.04% | JANX | JANUX THERAPEUTICS INC | -- | $37,322.88 | 2,777 | BMFX8Y7 |
| 0.04% | CSTL | CASTLE BIOSCIENCES INC | -- | $37,164.36 | 1,348 | BKLCWZ3 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $36,433.74 | 2,334 | BD06CS0 |
| 0.04% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $36,299.25 | 3,285 | BJLKVS6 |
| 0.04% | ANNX | ANNEXON INC | -- | $36,288.69 | 6,683 | BMVV9R5 |
| 0.04% | PSNL | PERSONALIS INC | -- | $35,555.67 | 4,101 | BJQ0608 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $35,257.05 | 8,335 | BPBJFM7 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $34,153.00 | 4,018 | BYZD465 |
| 0.04% | BIOA | BIOAGE LABS INC | -- | $33,881.76 | 1,656 | BT9K6D8 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $32,941.20 | 2,264 | BQS7491 |
| 0.04% | TBPH | THERAVANCE BIOPHARMA INC | -- | $32,666.40 | 2,340 | BMNDK09 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $32,120.58 | 11,038 | BBNBTD2 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $32,037.76 | 1,808 | BD9GVY0 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $30,239.45 | 4,351 | BMC3HS7 |
| 0.03% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $27,670.76 | 838 | BQD3J33 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $27,617.31 | 3,717 | BFYQFJ2 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $27,343.68 | 7,512 | B3MZ6K5 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $26,300.00 | 2,630 | BMFK3H6 |
| 0.03% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $26,253.81 | 10,377 | BFZNYB7 |
| 0.03% | QURE | UNIQURE NV | -- | $25,979.31 | 2,877 | BJFSR88 |
| 0.03% | REPL | REPLIMUNE GROUP INC | -- | $25,969.74 | 3,622 | BDDVW37 |
| 0.03% | CRMD | CORMEDIX INC | -- | $25,138.58 | 3,638 | BJ0LT31 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $24,708.24 | 6,696 | BMCWKZ2 |
| 0.03% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $23,952.00 | 4,990 | BDFKQ07 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $23,825.90 | 3,370 | BQ6C357 |
| 0.03% | KMDA | KAMADA LTD | -- | $23,789.52 | 2,664 | B2Q9833 |
| 0.03% | NMRA | NEUMORA THERAPEUTICS INC | -- | $23,607.90 | 7,715 | BN4JN37 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $23,259.60 | 2,485 | B91XRN2 |
| 0.03% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $23,207.96 | 5,633 | BYVQJ96 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $23,166.00 | 2,600 | BLFBZ32 |
| 0.03% | LYEL | LYELL IMMUNOPHARMA INC | -- | $22,840.07 | 979 | BTNMG41 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $22,317.48 | 2,638 | BKLXFX5 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $22,077.40 | 668 | B292NQ7 |
| 0.03% | LRMR | LARIMAR THERAPEUTICS INC | -- | $21,781.03 | 3,953 | BMXNGZ6 |
| 0.02% | ETON | ETON PHARMACEUTICALS INC | -- | $21,620.55 | 1,239 | BGL0JK3 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $21,444.08 | 3,598 | BQHN6C7 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $21,395.36 | 2,729 | B12W3P6 |
| 0.02% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $21,190.32 | 13,941 | B4N8MH9 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $21,077.28 | 864 | BPBPCG8 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $20,915.25 | 1,765 | BP81RK8 |
| 0.02% | IVVD | INVIVYD INC | -- | $20,729.52 | 12,796 | BM8NHS1 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $20,569.54 | 3,307 | 2107437 |
| 0.02% | PEPG | PEPGEN INC | -- | $20,383.50 | 3,175 | BMTX3D7 |
| 0.02% | RGNX | REGENXBIO INC | -- | $20,308.53 | 2,337 | BZ0G875 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $20,047.04 | 4,819 | BFY7DC4 |
| 0.02% | FULC | FULCRUM THERAPEUTICS INC | -- | $19,667.13 | 2,499 | BJDX8Z9 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $19,607.04 | 1,332 | B9L5200 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $19,346.25 | 4,125 | BYTYP72 |
| 0.02% | LENZ | LENZ THERAPEUTICS INC | -- | $19,001.75 | 1,445 | BQV0J03 |
| 0.02% | KROS | KEROS THERAPEUTICS INC | -- | $18,840.40 | 1,406 | BM7V485 |
| 0.02% | UPB | UPSTREAM BIO INC | -- | $18,363.20 | 2,495 | BRCFFK6 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $18,295.68 | 2,932 | BP81R42 |
| 0.02% | ABSI | ABSCI CORP | -- | $17,846.08 | 6,944 | BN94K69 |
| 0.02% | AVIR | ATEA PHARMACEUTICALS INC | -- | $17,385.74 | 3,607 | BLN9Z50 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $16,224.46 | 2,023 | BSMLR16 |
| 0.02% | NGNE | NEUROGENE INC | -- | $15,722.85 | 715 | BS2F741 |
| 0.02% | NBP | NOVABRIDGE BIOSCIENCES | -- | $15,363.20 | 4,801 | BKRRKY7 |
| 0.02% | ACRS | ACLARIS THERAPEUTICS INC | -- | $15,209.12 | 5,003 | BYV2W40 |
| 0.02% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $15,044.70 | 1,067 | BPRBTY7 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $15,004.44 | 9,262 | BFMLGR4 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $14,755.95 | 2,981 | BMVBZF5 |
| 0.02% | CABA | CABALETTA BIO INC | -- | $14,446.25 | 4,445 | BK5MWR1 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $14,444.46 | 2,326 | B7F2TY6 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $14,412.72 | 2,611 | BMF7DT9 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $13,490.76 | 4,636 | BZC0D70 |
| 0.02% | CCCC | C4 THERAPEUTICS INC | -- | $13,201.25 | 4,475 | BKX9NQ0 |
| 0.01% | CADL | CANDEL THERAPEUTICS INC | -- | $12,446.85 | 2,535 | BP0TQC5 |
| 0.01% | EOLS | EVOLUS INC | -- | $12,361.09 | 2,993 | BDRJH21 |
| 0.01% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $12,287.39 | 2,169 | BL5B6Z1 |
| 0.01% | LFCR | LIFECORE BIOMEDICAL INC | -- | $12,092.70 | 1,730 | 2517058 |
| 0.01% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $11,748.00 | 2,136 | BKDQKM6 |
| 0.01% | VOR | VOR BIOPHARMA INC | -- | $11,631.10 | 778 | BRJJYT3 |
| 0.01% | OABI | OMNIAB INC | -- | $11,499.31 | 6,647 | BN13S71 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $11,366.52 | 2,607 | BPRB2N7 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $11,074.47 | 2,721 | BY7RB53 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $10,377.92 | 1,312 | BKC9SX3 |
| 0.01% | HUMA | HUMACYTE INC | -- | $9,252.29 | 8,647 | BMYTJP4 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $9,208.65 | 5,581 | BRK0149 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $9,196.32 | 4,508 | BZ8FPH3 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $8,560.44 | 9,030 | BNR5QT9 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $8,047.84 | 1,432 | BP2NYN2 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $7,596.16 | 4,316 | BNYJR68 |
| 0.01% | MENS | JYONG BIOTECH LTD | -- | $7,513.54 | 3,511 | BPTK6Z2 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $6,215.52 | 4,504 | BNNXX18 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $6,051.30 | 2,631 | BKTV702 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $5,782.14 | 2,471 | BP7L561 |
| 0.01% | GOSS | GOSSAMER BIO INC | -- | $5,022.89 | 10,687 | BJ0CK86 |
| 0.01% | AARD | AARDVARK THERAPEUTICS INC | -- | $4,924.50 | 1,005 | BTXQTX3 |
| -- | TNYA | TENAYA THERAPEUTICS INC | -- | $4,228.40 | 7,688 | BNNXX52 |
| -- | PYXS | PYXIS ONCOLOGY INC | -- | $4,111.25 | 2,875 | BLBR8D5 |
| -- | CDXS | CODEXIS INC | -- | $4,087.58 | 4,171 | B5LL2C2 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $19.70 | 01 | BTFHQP5 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 37.19% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 32,216,471 | -- | 5,484 | -- |
| 29.10% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 25,208,037 | -- | 4,291 | -- |
| 25.94% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 22,476,334 | -- | 3,826 | -- |
| 17.90% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 15,503,149 | -- | 2,639 | -- |
| 16.84% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,592,581 | -- | 2,484 | -- |
| 4.29% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,718,641 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $26,535,267.48 | 26,535,267 | -- |
Index
as of 12/31/2025
- Total Number of Companies262
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$7.32 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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