BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 1/31/2026
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 4.27% | 16.53% | 65.39% | 4.27% | 51.38% | 11.58% | -2.47% | 6.91% | 16.64% | 04/07/2010 |
| BIB Market Price | 4.19% | 16.41% | 65.44% | 4.19% | 51.07% | 11.50% | -2.49% | 6.94% | 16.64% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 2/26/2026- NAV $86.67
- NAV Change $-1.26
- Market Price $86.65
- Market Price Change $-1.28
- Trading Volume (M) 7,607
- 30-Day Median Bid Ask Spread 0.27%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 2/26/2026- NAV $86.67
- NAV Change $-1.26
- Market Price $86.65
- Market Price Change $-1.28
- Trading Volume (M) 7,607
- 30-Day Median Bid Ask Spread 0.27%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 12/31/2025
Holdings
as of 2/26/2026
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 6.36% | GILD | GILEAD SCIENCES INC | -- | $5,736,998.08 | 39,904 | 2369174 |
| 6.17% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,560,385.53 | 11,581 | 2931034 |
| 6.12% | AMGN | AMGEN INC | -- | $5,513,940.88 | 14,536 | 2023607 |
| 4.08% | REGN | REGENERON PHARMACEUTICALS | -- | $3,675,897.51 | 4,769 | 2730190 |
| 2.24% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,020,895.24 | 6,101 | B00FWN1 |
| 1.64% | INSM | INSMED INC | -- | $1,477,200.00 | 9,848 | 2614487 |
| 1.41% | BIIB | BIOGEN INC | -- | $1,273,647.48 | 6,774 | 2455965 |
| 1.15% | ARGX | ARGENX SE - ADR | -- | $1,036,936.32 | 1,344 | BDVLM39 |
| 1.11% | UTHR | UNITED THERAPEUTICS CORP | -- | $1,001,156.80 | 1,988 | 2430412 |
| 1.03% | MRNA | MODERNA INC | -- | $932,796.69 | 18,039 | BGSXTS3 |
| 1.02% | ROIV | ROIVANT SCIENCES LTD | -- | $914,927.86 | 32,114 | BMW4NZ9 |
| 1.01% | RVMD | REVOLUTION MEDICINES INC | -- | $911,893.05 | 8,927 | BL71K91 |
| 1.01% | INCY | INCYTE CORP | -- | $907,315.85 | 9,065 | 2471950 |
| 1.00% | ILMN | ILLUMINA INC | -- | $898,807.00 | 7,055 | 2613990 |
| 0.99% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $894,907.44 | 19,729 | BMVP7Y0 |
| 0.90% | VTRS | VIATRIS INC | -- | $811,040.75 | 53,183 | BMWS3X9 |
| 0.72% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $649,186.65 | 2,835 | BV9G6B8 |
| 0.67% | IONS | IONIS PHARMACEUTICALS INC | -- | $602,807.40 | 7,479 | BDJ0LS6 |
| 0.67% | BBIO | BRIDGEBIO PHARMA INC | -- | $601,526.17 | 8,897 | BK1KWG8 |
| 0.67% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $601,466.56 | 4,604 | 2623911 |
| 0.66% | SNY | SANOFI-ADR | -- | $590,788.65 | 12,219 | 2964557 |
| 0.65% | GH | GUARDANT HEALTH INC | -- | $585,272.78 | 5,974 | BFXC911 |
| 0.65% | MEDP | MEDPACE HOLDINGS INC | -- | $581,664.09 | 1,301 | BDCBC61 |
| 0.61% | EXEL | EXELIXIS INC | -- | $548,230.68 | 12,381 | 2576941 |
| 0.60% | SMMT | SUMMIT THERAPEUTICS INC | -- | $543,125.00 | 34,375 | BMTVQS7 |
| 0.60% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $542,106.81 | 8,871 | 2437071 |
| 0.59% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $530,249.82 | 2,806 | B4Q5ZN4 |
| 0.56% | BNTX | BIONTECH SE-ADR | -- | $507,987.20 | 4,669 | BK6H543 |
| 0.52% | ONC | BEONE MEDICINES LTD-ADR | -- | $468,725.98 | 1,454 | BYYWPW6 |
| 0.52% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $467,250.80 | 1,048 | BD59BS7 |
| 0.49% | TEM | TEMPUS AI INC-CL A | -- | $442,282.62 | 7,982 | BSLSJJ0 |
| 0.48% | IBRX | IMMUNITYBIO INC | -- | $434,343.55 | 45,481 | BNSP0B8 |
| 0.44% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $397,518.69 | 6,271 | BYQBFJ8 |
| 0.44% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $393,242.85 | 1,155 | BQ721R4 |
| 0.42% | AXSM | AXSOME THERAPEUTICS INC | -- | $379,743.13 | 2,327 | BYZR4X4 |
| 0.42% | HALO | HALOZYME THERAPEUTICS INC | -- | $375,864.60 | 5,430 | 2975098 |
| 0.41% | KRYS | KRYSTAL BIOTECH INC | -- | $370,046.04 | 1,339 | BD6JX35 |
| 0.40% | PCVX | VAXCYTE INC | -- | $362,640.00 | 6,044 | BKPVGH6 |
| 0.39% | CYTK | CYTOKINETICS INC | -- | $353,608.98 | 5,646 | BBBSBJ5 |
| 0.38% | NUVL | NUVALENT INC-A | -- | $346,606.55 | 3,335 | BMVBZD3 |
| 0.36% | ABVX | ABIVAX SA-ADR | -- | $325,675.22 | 2,726 | BLC89B2 |
| 0.35% | KYMR | KYMERA THERAPEUTICS INC | -- | $315,689.66 | 3,322 | BMPRZV5 |
| 0.34% | ACLX | ARCELLX INC | -- | $304,059.60 | 2,670 | BPCJ1Q2 |
| 0.34% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $302,251.74 | 3,082 | BF2YWG4 |
| 0.31% | COGT | COGENT BIOSCIENCES INC | -- | $279,692.48 | 7,088 | BLR6XK8 |
| 0.30% | CRSP | CRISPR THERAPEUTICS AG | -- | $271,656.00 | 4,400 | BDHF4K6 |
| 0.28% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $255,181.93 | 2,887 | BDCBCD8 |
| 0.28% | PTCT | PTC THERAPEUTICS INC | -- | $252,446.70 | 3,707 | B17VCN9 |
| 0.28% | CAI | CARIS LIFE SCIENCES INC | -- | $250,677.96 | 13,029 | BT18HP9 |
| 0.26% | ALKS | ALKERMES PLC | -- | $234,285.52 | 7,624 | B3P6D26 |
| 0.25% | IMVT | IMMUNOVANT INC | -- | $221,856.54 | 8,094 | BJRFSB7 |
| 0.24% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $218,766.87 | 2,373 | BJDX8Y8 |
| 0.23% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $211,196.40 | 4,710 | BFZQ0L8 |
| 0.23% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $210,336.84 | 14,516 | BFNF1D6 |
| 0.23% | CGON | CG ONCOLOGY INC | -- | $209,009.75 | 3,725 | BRBCSP4 |
| 0.23% | FOLD | AMICUS THERAPEUTICS INC | -- | $204,159.51 | 14,247 | B19FQ48 |
| 0.22% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $199,818.50 | 3,086 | BQS9486 |
| 0.22% | INDV | INDIVIOR PHARMACEUTICALS INC | -- | $194,270.73 | 5,763 | BTZRLN8 |
| 0.21% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $192,487.68 | 7,812 | 2713317 |
| 0.21% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $191,668.68 | 4,382 | BDD19F8 |
| -- | -- | NEWAMSTERDAM PHARMA CO NV | -- | $179,490.08 | 5,236 | BP8JSP4 |
| 0.20% | LGND | LIGAND PHARMACEUTICALS | -- | $178,318.53 | 909 | 2501578 |
| 0.20% | ERAS | ERASCA INC | -- | $177,780.57 | 13,101 | BNLYBF3 |
| 0.19% | APGE | APOGEE THERAPEUTICS INC | -- | $174,935.88 | 2,532 | BM9HHL5 |
| 0.19% | TERN | TERNS PHARMACEUTICALS INC | -- | $170,227.20 | 4,160 | BMDJ0C9 |
| 0.19% | ADMA | ADMA BIOLOGICS INC | -- | $166,828.20 | 10,990 | B9NSBM2 |
| 0.18% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $161,591.92 | 5,656 | BKX9VD3 |
| 0.18% | XENE | XENON PHARMACEUTICALS INC | -- | $160,274.56 | 3,568 | BRJ3GY4 |
| 0.17% | SYRE | SPYRE THERAPEUTICS INC | -- | $154,606.45 | 3,583 | BQBBDY8 |
| 0.17% | TARS | TARSUS PHARMACEUTICALS INC | -- | $148,781.07 | 1,961 | BMH5RL1 |
| 0.16% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $147,626.00 | 2,648 | B72ZBG4 |
| 0.16% | DNLI | DENALI THERAPEUTICS INC | -- | $145,056.24 | 6,772 | BD2B4V0 |
| 0.16% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $145,007.74 | 4,889 | BKY5JZ8 |
| 0.16% | VCYT | VERACYTE INC | -- | $141,437.50 | 3,650 | BFTWZY0 |
| 0.15% | TWST | TWIST BIOSCIENCE CORP | -- | $137,508.33 | 2,823 | BGKG6G7 |
| 0.15% | BEAM | BEAM THERAPEUTICS INC | -- | $135,490.20 | 4,685 | BK6L288 |
| 0.15% | ALMS | ALUMIS INC | -- | $134,580.22 | 4,489 | BPLQG36 |
| 0.14% | IDYA | IDEAYA BIOSCIENCES INC | -- | $129,131.20 | 4,048 | BK0VHF6 |
| 0.14% | APLS | APELLIS PHARMACEUTICALS INC | -- | $126,355.96 | 5,839 | BYTQ6X1 |
| 0.14% | VERA | VERA THERAPEUTICS INC | -- | $124,932.50 | 2,950 | BL55460 |
| 0.14% | TVTX | TRAVERE THERAPEUTICS INC | -- | $122,773.32 | 4,131 | BLFGJD5 |
| 0.13% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $119,260.35 | 4,455 | BLB0YQ9 |
| 0.13% | TXG | 10X GENOMICS INC-CLASS A | -- | $119,037.27 | 5,379 | BKS3RS7 |
| 0.13% | WVE | WAVE LIFE SCIENCES LTD | -- | $118,625.28 | 7,723 | BYZG9R0 |
| 0.13% | IRON | DISC MEDICINE INC | -- | $118,435.04 | 1,744 | BMGJZJ8 |
| 0.13% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $116,026.54 | 7,049 | BJ5FZ74 |
| 0.12% | DYN | DYNE THERAPEUTICS INC | -- | $106,773.05 | 6,595 | BN15WD1 |
| 0.12% | MLYS | MINERALYS THERAPEUTICS INC | -- | $106,075.62 | 3,654 | BP9N0G0 |
| 0.12% | GRAL | GRAIL INC | -- | $104,580.00 | 1,800 | BSLSSX7 |
| 0.11% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $102,643.20 | 4,455 | BJ62Z18 |
| 0.11% | MAZE | MAZE THERAPEUTICS INC | -- | $101,856.48 | 2,222 | BSRK699 |
| 0.10% | OCUL | OCULAR THERAPEUTIX INC | -- | $94,336.83 | 9,837 | BNZB1X8 |
| 0.10% | STOK | STOKE THERAPEUTICS INC | -- | $93,780.90 | 2,638 | BJQ05Z6 |
| 0.10% | HROW | HARROW INC | -- | $92,322.90 | 1,710 | BHNDW86 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $90,720.14 | 2,086 | BRXB0C0 |
| 0.10% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $89,511.11 | 23,743 | BM9FJ13 |
| 0.10% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $88,584.48 | 3,632 | BMZ4LN0 |
| 0.10% | VCEL | VERICEL CORP | -- | $87,982.80 | 2,335 | BSBMN89 |
| 0.09% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $85,049.36 | 6,088 | BFWLC09 |
| 0.09% | SRPT | SAREPTA THERAPEUTICS INC | -- | $84,423.10 | 4,838 | B8DPDT7 |
| 0.09% | NVAX | NOVAVAX INC | -- | $83,969.76 | 7,504 | BJDQXG4 |
| 0.09% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $82,969.38 | 4,014 | BN7Q7R7 |
| 0.09% | PHVS | PHARVARIS NV | -- | $82,824.00 | 2,958 | BMZ2X38 |
| 0.09% | ZYME | ZYMEWORKS INC | -- | $82,287.36 | 3,456 | BPCQZY9 |
| 0.09% | TYRA | TYRA BIOSCIENCES INC | -- | $81,755.52 | 2,464 | BMVNDH9 |
| 0.09% | INVA | INNOVIVA INC | -- | $81,283.62 | 3,453 | BDDXF67 |
| 0.09% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $81,188.42 | 2,741 | BMFD115 |
| 0.09% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $80,706.16 | 2,692 | BCBVTX1 |
| 0.09% | ANIP | ANI PHARMACEUTICALS INC | -- | $80,004.55 | 1,037 | BCDWBX6 |
| 0.09% | GMAB | GENMAB A/S -SP ADR | -- | $78,918.76 | 2,699 | BBC9WC7 |
| 0.09% | DFTX | DEFINIUM THERAPEUTICS INC | -- | $78,634.92 | 4,548 | BV2DHY6 |
| 0.09% | SION | SIONNA THERAPEUTICS INC | -- | $78,318.00 | 2,061 | BQKXDX4 |
| 0.09% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $77,383.46 | 5,071 | BPCK358 |
| 0.09% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $77,273.00 | 2,660 | BKSGZN7 |
| 0.09% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $76,803.80 | 9,722 | 2100362 |
| 0.09% | ORKA | ORUKA THERAPEUTICS INC | -- | $76,739.52 | 2,236 | BKVF0J2 |
| 0.08% | NTLA | INTELLIA THERAPEUTICS INC | -- | $76,369.44 | 5,348 | BYZM6C2 |
| 0.08% | NRIX | NURIX THERAPEUTICS INC | -- | $75,394.80 | 4,680 | BMVLGP2 |
| 0.08% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $74,960.64 | 3,888 | BMX9K07 |
| 0.08% | ARDX | ARDELYX INC | -- | $74,388.60 | 11,220 | BN89V40 |
| 0.08% | RAPT | RAPT THERAPEUTICS INC | -- | $74,130.84 | 1,279 | BTJZB49 |
| 0.08% | RLAY | RELAY THERAPEUTICS INC | -- | $73,307.48 | 8,003 | BN2R582 |
| 0.08% | MBX | MBX BIOSCIENCES INC | -- | $72,637.92 | 2,073 | BQXJKH2 |
| 0.08% | ANAB | ANAPTYSBIO INC | -- | $71,708.58 | 1,278 | BDRW1L7 |
| 0.08% | NVCR | NOVOCURE LTD | -- | $71,101.25 | 5,171 | BYSS4X4 |
| 0.08% | TNGX | TANGO THERAPEUTICS INC | -- | $70,896.60 | 6,219 | BP2P6L0 |
| 0.08% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $69,470.70 | 18,330 | BF0DMK7 |
| 0.08% | KOD | KODIAK SCIENCES INC | -- | $68,551.00 | 2,450 | BFXC933 |
| 0.08% | EYPT | EYEPOINT INC | -- | $68,260.92 | 3,822 | BMGS7L1 |
| 0.08% | TRVI | TREVI THERAPEUTICS INC | -- | $68,209.92 | 5,921 | BJH9ZN0 |
| 0.07% | ZBIO | ZENAS BIOPHARMA INC | -- | $65,320.08 | 2,478 | BQB42H3 |
| 0.07% | RAPP | RAPPORT THERAPEUTICS INC | -- | $64,929.50 | 2,201 | BR3T9B6 |
| 0.07% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $64,561.20 | 1,460 | BX7RSN3 |
| 0.07% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $64,560.60 | 2,015 | BLCD809 |
| 0.07% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $62,978.74 | 3,449 | BYP80F1 |
| 0.07% | SEPN | SEPTERNA INC | -- | $62,588.76 | 2,067 | BQNKXX2 |
| 0.07% | ATAI | ATAIBECKLEY INC | -- | $62,552.10 | 16,770 | BWJDYK1 |
| 0.07% | PGEN | PRECIGEN INC | -- | $62,247.78 | 16,338 | BKM5C84 |
| 0.07% | ORIC | ORIC PHARMACEUTICALS INC | -- | $60,709.50 | 4,497 | BKVDFF7 |
| 0.07% | ALVO | ALVOTECH SA | -- | $60,128.64 | 14,454 | BPNTJ34 |
| 0.07% | VIR | VIR BIOTECHNOLOGY INC | -- | $59,871.68 | 6,424 | BK4PZ38 |
| 0.06% | TSHA | TAYSHA GENE THERAPIES INC | -- | $57,801.36 | 12,648 | BNC1BX1 |
| 0.06% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $56,211.78 | 2,122 | BNFWZS4 |
| 0.06% | SVRA | SAVARA INC | -- | $56,088.15 | 9,395 | BYXGN81 |
| 0.06% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $55,629.50 | 3,007 | BP7KZP7 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $52,521.00 | 12,300 | BMFJJ97 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $51,898.56 | 672 | BNSP8K3 |
| 0.06% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $51,746.20 | 946 | BL95N25 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $51,641.88 | 7,662 | BLR7H87 |
| 0.06% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $50,491.65 | 4,741 | BLB0YH0 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $50,471.68 | 5,633 | B8K7T65 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $49,620.98 | 13,822 | BL53SR3 |
| 0.05% | QURE | UNIQURE NV | -- | $49,239.86 | 2,877 | BJFSR88 |
| 0.05% | GERN | GERON CORP | -- | $48,635.40 | 29,476 | 2370381 |
| 0.05% | FTRE | FORTREA HOLDINGS INC | -- | $46,072.80 | 4,266 | BRXYZ57 |
| 0.05% | VTYX | VENTYX BIOSCIENCES INC | -- | $46,031.15 | 3,295 | BMG99Y1 |
| 0.05% | MNKD | MANNKIND CORP | -- | $45,943.20 | 14,180 | BF081J4 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $45,791.16 | 2,162 | BZ7PJQ1 |
| 0.05% | PCRX | PACIRA BIOSCIENCES INC | -- | $44,863.74 | 1,986 | B3X26D8 |
| 0.05% | GHRS | GH RESEARCH PLC | -- | $44,764.32 | 2,864 | BP6C0S2 |
| 0.05% | XNCR | XENCOR INC | -- | $44,687.90 | 3,298 | BGCYWN8 |
| 0.05% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $44,544.60 | 3,285 | BJLKVS6 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $44,276.38 | 1,906 | BMGTLY5 |
| 0.05% | CSTL | CASTLE BIOSCIENCES INC | -- | $42,974.24 | 1,348 | BKLCWZ3 |
| 0.05% | CTMX | CYTOMX THERAPEUTICS INC | -- | $42,870.04 | 7,823 | BYWVTY5 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $42,627.76 | 4,564 | BMCR7V2 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $42,564.60 | 2,340 | BMNDK09 |
| 0.05% | BCAX | BICARA THERAPEUTICS INC | -- | $42,504.00 | 2,530 | BQB42F1 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $41,740.70 | 8,881 | BZ0QMB7 |
| 0.05% | CGEM | CULLINAN THERAPEUTICS INC | -- | $41,492.88 | 2,728 | BM90J52 |
| 0.04% | ARVN | ARVINAS INC | -- | $39,671.70 | 2,965 | BDZ30Q0 |
| 0.04% | JANX | JANUX THERAPEUTICS INC | -- | $38,322.60 | 2,777 | BMFX8Y7 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $38,306.88 | 2,264 | BQS7491 |
| 0.04% | OMER | OMEROS CORP | -- | $37,814.70 | 3,274 | B4NB858 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $37,087.68 | 11,038 | BBNBTD2 |
| 0.04% | PSNL | PERSONALIS INC | -- | $37,032.03 | 4,101 | BJQ0608 |
| 0.04% | BIOA | BIOAGE LABS INC | -- | $36,961.92 | 1,656 | BT9K6D8 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $36,783.84 | 2,334 | BD06CS0 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $36,507.30 | 8,335 | BPBJFM7 |
| 0.04% | ANNX | ANNEXON INC | -- | $35,954.54 | 6,683 | BMVV9R5 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $35,599.52 | 1,808 | BD9GVY0 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $34,755.70 | 4,018 | BYZD465 |
| 0.04% | CMPS | COMPASS PATHWAYS PLC | -- | $31,892.83 | 4,351 | BMC3HS7 |
| 0.03% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $29,924.98 | 838 | BQD3J33 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $28,472.22 | 3,717 | BFYQFJ2 |
| 0.03% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $28,329.21 | 10,377 | BFZNYB7 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $28,088.40 | 2,630 | BMFK3H6 |
| 0.03% | REPL | REPLIMUNE GROUP INC | -- | $27,853.18 | 3,622 | BDDVW37 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $27,493.92 | 7,512 | B3MZ6K5 |
| 0.03% | NMRA | NEUMORA THERAPEUTICS INC | -- | $27,388.25 | 7,715 | BN4JN37 |
| 0.03% | CRMD | CORMEDIX INC | -- | $26,739.30 | 3,638 | BJ0LT31 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $25,483.08 | 2,638 | BKLXFX5 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $24,814.98 | 13,941 | B4N8MH9 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $23,837.76 | 6,696 | BMCWKZ2 |
| 0.03% | KMDA | KAMADA LTD | -- | $23,736.24 | 2,664 | B2Q9833 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $23,634.00 | 2,600 | BLFBZ32 |
| 0.03% | VNDA | VANDA PHARMACEUTICALS INC | -- | $23,469.40 | 2,729 | B12W3P6 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $23,253.00 | 3,370 | BQ6C357 |
| 0.03% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $23,151.63 | 5,633 | BYVQJ96 |
| 0.03% | SLDB | SOLID BIOSCIENCES INC | -- | $22,631.42 | 3,598 | BQHN6C7 |
| 0.03% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $22,604.70 | 4,990 | BDFKQ07 |
| 0.03% | TRDA | ENTRADA THERAPEUTICS INC | -- | $22,574.35 | 1,765 | BP81RK8 |
| 0.02% | LYEL | LYELL IMMUNOPHARMA INC | -- | $22,526.79 | 979 | BTNMG41 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $22,371.32 | 668 | B292NQ7 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $21,958.48 | 3,307 | 2107437 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $21,820.56 | 3,953 | BMXNGZ6 |
| 0.02% | FULC | FULCRUM THERAPEUTICS INC | -- | $21,816.27 | 2,499 | BJDX8Z9 |
| 0.02% | IVVD | INVIVYD INC | -- | $21,753.20 | 12,796 | BM8NHS1 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $21,492.74 | 4,819 | BFY7DC4 |
| 0.02% | PRTA | PROTHENA CORP PLC | -- | $21,470.40 | 2,485 | B91XRN2 |
| 0.02% | ETON | ETON PHARMACEUTICALS INC | -- | $21,372.75 | 1,239 | BGL0JK3 |
| 0.02% | KROS | KEROS THERAPEUTICS INC | -- | $21,132.18 | 1,406 | BM7V485 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $20,675.52 | 864 | BPBPCG8 |
| 0.02% | RGNX | REGENXBIO INC | -- | $20,448.75 | 2,337 | BZ0G875 |
| 0.02% | PEPG | PEPGEN INC | -- | $19,812.00 | 3,175 | BMTX3D7 |
| 0.02% | UPB | UPSTREAM BIO INC | -- | $19,710.50 | 2,495 | BRCFFK6 |
| 0.02% | LENZ | LENZ THERAPEUTICS INC | -- | $19,536.40 | 1,445 | BQV0J03 |
| 0.02% | ABSI | ABSCI CORP | -- | $19,512.64 | 6,944 | BN94K69 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $19,194.12 | 1,332 | B9L5200 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $18,397.50 | 4,125 | BYTYP72 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $17,677.60 | 2,326 | B7F2TY6 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $17,533.36 | 2,932 | BP81R42 |
| 0.02% | AVIR | ATEA PHARMACEUTICALS INC | -- | $16,880.76 | 3,607 | BLN9Z50 |
| 0.02% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $16,837.26 | 1,067 | BPRBTY7 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $16,426.76 | 2,023 | BSMLR16 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $16,393.74 | 9,262 | BFMLGR4 |
| 0.02% | NBP | NOVABRIDGE BIOSCIENCES | -- | $15,747.28 | 4,801 | BKRRKY7 |
| 0.02% | ACRS | ACLARIS THERAPEUTICS INC | -- | $15,659.39 | 5,003 | BYV2W40 |
| 0.02% | CABA | CABALETTA BIO INC | -- | $15,468.60 | 4,445 | BK5MWR1 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $15,039.36 | 2,611 | BMF7DT9 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $14,875.19 | 2,981 | BMVBZF5 |
| 0.02% | NGNE | NEUROGENE INC | -- | $14,071.20 | 715 | BS2F741 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $13,722.56 | 4,636 | BZC0D70 |
| 0.01% | EOLS | EVOLUS INC | -- | $13,438.57 | 2,993 | BDRJH21 |
| 0.01% | CADL | CANDEL THERAPEUTICS INC | -- | $13,055.25 | 2,535 | BP0TQC5 |
| 0.01% | LFCR | LIFECORE BIOMEDICAL INC | -- | $12,750.10 | 1,730 | 2517058 |
| 0.01% | AARD | AARDVARK THERAPEUTICS INC | -- | $12,562.50 | 1,005 | BTXQTX3 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $12,440.50 | 4,475 | BKX9NQ0 |
| 0.01% | VOR | VOR BIOPHARMA INC | -- | $12,370.20 | 778 | BRJJYT3 |
| 0.01% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $12,047.04 | 2,136 | BKDQKM6 |
| 0.01% | OABI | OMNIAB INC | -- | $11,964.60 | 6,647 | BN13S71 |
| 0.01% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $11,755.98 | 2,169 | BL5B6Z1 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $11,509.83 | 2,721 | BY7RB53 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $11,288.31 | 2,607 | BPRB2N7 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $10,915.84 | 1,312 | BKC9SX3 |
| 0.01% | HUMA | HUMACYTE INC | -- | $10,635.81 | 8,647 | BMYTJP4 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $9,827.44 | 4,508 | BZ8FPH3 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $9,431.89 | 5,581 | BRK0149 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $9,120.30 | 9,030 | BNR5QT9 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $8,588.84 | 4,316 | BNYJR68 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $8,405.84 | 1,432 | BP2NYN2 |
| 0.01% | MENS | JYONG BIOTECH LTD | -- | $8,075.30 | 3,511 | BPTK6Z2 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $6,577.50 | 2,631 | BKTV702 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $6,215.52 | 4,504 | BNNXX18 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $5,633.88 | 2,471 | BP7L561 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $4,682.76 | 7,688 | BNNXX52 |
| -- | CDXS | CODEXIS INC | -- | $4,462.97 | 4,171 | B5LL2C2 |
| -- | PYXS | PYXIS ONCOLOGY INC | -- | $4,370.00 | 2,875 | BLBR8D5 |
| -- | GOSS | GOSSAMER BIO INC | -- | $4,296.17 | 10,687 | BJ0CK86 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $20.47 | 01 | BTFHQP5 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| -- | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 36,998,245 | -- | 6,179 | -- |
| -- | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 25,693,392 | -- | 4,291 | -- |
| -- | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 21,831,300 | -- | 3,646 | -- |
| -- | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 15,801,646 | -- | 2,639 | -- |
| -- | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,873,546 | -- | 2,484 | -- |
| -- | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,790,239 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $28,807,792.32 | 28,807,792 | -- |
Index
as of 12/31/2025
- Total Number of Companies262
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$7.32 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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