BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 10/31/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 20.05% | 41.93% | 51.59% | 42.58% | 20.67% | 9.55% | 2.60% | 0.91% | 15.79% | 04/07/2010 |
| BIB Market Price | 20.06% | 42.12% | 51.73% | 42.51% | 20.92% | 9.51% | 2.55% | 0.91% | 15.79% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/05/2025- NAV $81.15
- NAV Change $-0.77
- Market Price $81.16
- Market Price Change $-0.71
- Trading Volume (M) 11,124
- 30-Day Median Bid Ask Spread 0.27%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/05/2025- NAV $81.15
- NAV Change $-0.77
- Market Price $81.16
- Market Price Change $-0.71
- Trading Volume (M) 11,124
- 30-Day Median Bid Ask Spread 0.27%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 12/05/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.30% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $4,559,354.80 | 10,010 | 2931034 |
| 5.22% | AMGN | AMGEN INC | -- | $4,487,823.56 | 13,604 | 2023607 |
| 4.88% | GILD | GILEAD SCIENCES INC | -- | $4,200,273.00 | 34,650 | 2369174 |
| 4.08% | REGN | REGENERON PHARMACEUTICALS | -- | $3,510,625.32 | 4,887 | 2730190 |
| 3.28% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,816,979.88 | 6,149 | B00FWN1 |
| 2.57% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $2,208,778.74 | 24,493 | 2989044 |
| 2.37% | INSM | INSMED INC | -- | $2,039,796.00 | 9,999 | 2614487 |
| 1.52% | ARGX | ARGENX SE - ADR | -- | $1,303,992.99 | 1,447 | BDVLM39 |
| 1.46% | BIIB | BIOGEN INC | -- | $1,257,315.50 | 6,935 | 2455965 |
| 1.22% | UTHR | UNITED THERAPEUTICS CORP | -- | $1,046,634.09 | 2,139 | 2430412 |
| 1.10% | INCY | INCYTE CORP | -- | $946,874.72 | 9,236 | 2471950 |
| 1.09% | ILMN | ILLUMINA INC | -- | $937,539.20 | 7,270 | 2613990 |
| 0.94% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $812,359.31 | 20,447 | BMVP7Y0 |
| 0.85% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $729,341.90 | 4,690 | 2623911 |
| 0.85% | MEDP | MEDPACE HOLDINGS INC | -- | $728,451.48 | 1,329 | BDCBC61 |
| 0.82% | RVMD | REVOLUTION MEDICINES INC | -- | $704,176.88 | 8,842 | BL71K91 |
| 0.79% | ROIV | ROIVANT SCIENCES LTD | -- | $677,331.00 | 32,300 | BMW4NZ9 |
| 0.77% | BBIO | BRIDGEBIO PHARMA INC | -- | $665,779.24 | 9,041 | BK1KWG8 |
| 0.75% | SMMT | SUMMIT THERAPEUTICS INC | -- | $643,340.16 | 35,136 | BMTVQS7 |
| 0.73% | SNY | SANOFI-ADR | -- | $628,684.29 | 12,693 | 2964557 |
| 0.72% | IONS | IONIS PHARMACEUTICALS INC | -- | $615,703.84 | 7,538 | BDJ0LS6 |
| 0.71% | TEM | TEMPUS AI INC | -- | $611,593.48 | 7,978 | BSLSJJ0 |
| 0.71% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $610,206.10 | 1,057 | BD59BS7 |
| 0.70% | VTRS | VIATRIS INC | -- | $602,723.92 | 55,144 | BMWS3X9 |
| 0.70% | GH | GUARDANT HEALTH INC | -- | $601,815.98 | 5,899 | BFXC911 |
| 0.69% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $589,818.24 | 2,871 | BV9G6B8 |
| 0.66% | EXEL | EXELIXIS INC | -- | $564,791.52 | 12,732 | 2576941 |
| 0.60% | ONC | BEONE MEDICINES LTD-ADR | -- | $513,411.00 | 1,590 | BYYWPW6 |
| 0.59% | MRNA | MODERNA INC | -- | $509,763.10 | 18,403 | BGSXTS3 |
| 0.57% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $486,699.60 | 2,868 | B4Q5ZN4 |
| 0.56% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $484,872.00 | 9,080 | 2437071 |
| 0.53% | BNTX | BIONTECH SE-ADR | -- | $457,957.50 | 4,758 | BK6H543 |
| 0.51% | RNA | AVIDITY BIOSCIENCES INC | -- | $435,868.55 | 6,085 | BMWHPY1 |
| 0.47% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $401,817.60 | 6,540 | BYQBFJ8 |
| 0.43% | CYTK | CYTOKINETICS INC | -- | $371,692.20 | 5,660 | BBBSBJ5 |
| 0.41% | AXSM | AXSOME THERAPEUTICS INC | -- | $352,308.42 | 2,361 | BYZR4X4 |
| 0.41% | HALO | HALOZYME THERAPEUTICS INC | -- | $350,341.56 | 5,532 | 2975098 |
| 0.40% | NUVL | NUVALENT INC-A | -- | $345,678.40 | 3,154 | BMVBZD3 |
| 0.40% | MRUS | MERUS NV | -- | $343,892.78 | 3,577 | BZBY005 |
| 0.38% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $328,653.20 | 3,142 | BF2YWG4 |
| 0.37% | KRYS | KRYSTAL BIOTECH INC | -- | $320,289.84 | 1,368 | BD6JX35 |
| 0.34% | PTCT | PTC THERAPEUTICS INC | -- | $290,324.29 | 3,758 | B17VCN9 |
| 0.33% | PCVX | VAXCYTE INC | -- | $285,433.68 | 6,141 | BKPVGH6 |
| 0.31% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $263,750.30 | 2,942 | BDCBCD8 |
| 0.30% | COGT | COGENT BIOSCIENCES INC | -- | $256,192.16 | 6,608 | BLR6XK8 |
| 0.29% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $246,998.04 | 996 | BQ721R4 |
| 0.28% | CRSP | CRISPR THERAPEUTICS AG | -- | $244,242.72 | 4,294 | BDHF4K6 |
| 0.27% | ALKS | ALKERMES PLC | -- | $230,492.16 | 7,808 | B3P6D26 |
| 0.26% | KYMR | KYMERA THERAPEUTICS INC | -- | $225,308.84 | 3,382 | BMPRZV5 |
| 0.26% | ADMA | ADMA BIOLOGICS INC | -- | $224,046.95 | 11,287 | B9NSBM2 |
| 0.25% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $218,971.20 | 7,980 | 2713317 |
| 0.24% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $207,868.18 | 4,454 | BDD19F8 |
| 0.24% | INDV | INDIVIOR PLC | -- | $207,278.24 | 5,902 | BP0BQQ5 |
| 0.24% | AKRO | AKERO THERAPEUTICS INC | -- | $206,417.20 | 3,784 | BK7Y2V9 |
| 0.24% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $204,750.96 | 4,548 | BFZQ0L8 |
| 0.22% | IMVT | IMMUNOVANT INC | -- | $188,292.96 | 8,244 | BJRFSB7 |
| 0.22% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $187,794.76 | 5,326 | BP8JSP4 |
| 0.21% | ACLX | ARCELLX INC | -- | $182,455.88 | 2,623 | BPCJ1Q2 |
| 0.21% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $180,933.90 | 14,855 | BFNF1D6 |
| 0.21% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $176,841.60 | 5,668 | BKX9VD3 |
| 0.20% | GRAL | GRAIL INC | -- | $172,271.88 | 1,706 | BSLSSX7 |
| 0.20% | LGND | LIGAND PHARMACEUTICALS | -- | $171,374.49 | 927 | 2501578 |
| 0.19% | APGE | APOGEE THERAPEUTICS INC | -- | $167,468.50 | 2,182 | BM9HHL5 |
| 0.19% | VCYT | VERACYTE INC | -- | $165,993.81 | 3,721 | BFTWZY0 |
| 0.19% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $165,856.42 | 4,559 | BJ62Z18 |
| 0.19% | XENE | XENON PHARMACEUTICALS INC | -- | $164,151.47 | 3,647 | BRJ3GY4 |
| 0.19% | TARS | TARSUS PHARMACEUTICALS INC | -- | $163,212.92 | 1,996 | BMH5RL1 |
| 0.19% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $162,708.48 | 2,376 | BJDX8Y8 |
| 0.18% | CGON | CG ONCOLOGY INC | -- | $156,183.10 | 3,607 | BRBCSP4 |
| 0.18% | IRON | DISC MEDICINE INC | -- | $153,226.18 | 1,643 | BMGJZJ8 |
| 0.17% | IDYA | IDEAYA BIOSCIENCES INC | -- | $148,645.28 | 4,144 | BK0VHF6 |
| 0.17% | TVTX | TRAVERE THERAPEUTICS INC | -- | $147,525.00 | 4,215 | BLFGJD5 |
| 0.17% | FOLD | AMICUS THERAPEUTICS INC | -- | $144,342.00 | 14,580 | B19FQ48 |
| 0.16% | APLS | APELLIS PHARMACEUTICALS INC | -- | $141,165.62 | 5,974 | BYTQ6X1 |
| 0.16% | DNLI | DENALI THERAPEUTICS INC | -- | $138,063.32 | 6,917 | BD2B4V0 |
| 0.16% | DYN | DYNE THERAPEUTICS INC | -- | $136,443.84 | 6,728 | BN15WD1 |
| 0.16% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $135,641.85 | 4,535 | BLB0YQ9 |
| 0.16% | VERA | VERA THERAPEUTICS INC | -- | $135,508.20 | 3,018 | BL55460 |
| 0.15% | BEAM | BEAM THERAPEUTICS INC | -- | $129,652.74 | 4,786 | BK6L288 |
| 0.14% | TERN | TERNS PHARMACEUTICALS INC | -- | $121,344.88 | 4,133 | BMDJ0C9 |
| 0.14% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $121,189.04 | 2,653 | B72ZBG4 |
| 0.14% | MLYS | MINERALYS THERAPEUTICS INC | -- | $120,736.00 | 3,136 | BP9N0G0 |
| 0.14% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $117,548.97 | 4,983 | BKY5JZ8 |
| 0.13% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $112,013.66 | 3,982 | BMX9K07 |
| 0.13% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $108,337.60 | 2,720 | BKSGZN7 |
| 0.12% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $106,229.50 | 7,202 | BJ5FZ74 |
| 0.12% | OCUL | OCULAR THERAPEUTIX INC | -- | $103,520.82 | 8,229 | BNZB1X8 |
| 0.12% | SRPT | SAREPTA THERAPEUTICS INC | -- | $102,907.98 | 4,623 | B8DPDT7 |
| 0.12% | IBRX | IMMUNITYBIO INC | -- | $102,383.61 | 44,709 | BNSP0B8 |
| 0.11% | AVDL | AVADEL PHARMACEUTICALS | -- | $97,993.28 | 4,592 | BDGMC59 |
| 0.11% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $97,424.64 | 2,819 | BQS9486 |
| 0.11% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $97,250.12 | 6,226 | BFWLC09 |
| 0.11% | TXG | 10X GENOMICS INC-CLASS A | -- | $96,171.24 | 5,412 | BKS3RS7 |
| 0.11% | SYRE | SPYRE THERAPEUTICS INC | -- | $95,566.65 | 2,857 | BQBBDY8 |
| 0.11% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $95,198.52 | 20,212 | BM9FJ13 |
| 0.11% | ZYME | ZYMEWORKS INC | -- | $94,882.95 | 3,555 | BPCQZY9 |
| 0.11% | TWST | TWIST BIOSCIENCE CORP | -- | $92,216.50 | 2,855 | BGKG6G7 |
| 0.10% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $88,323.66 | 3,246 | BMZ4LN0 |
| 0.10% | VCEL | VERICEL CORP | -- | $86,444.78 | 2,386 | BSBMN89 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $85,673.52 | 2,056 | BRXB0C0 |
| 0.10% | ANIP | ANI PHARMACEUTICALS INC | -- | $83,896.02 | 1,026 | BCDWBX6 |
| 0.10% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $82,804.00 | 4,075 | BN7Q7R7 |
| 0.10% | MNKD | MANNKIND CORP | -- | $82,433.84 | 14,513 | BF081J4 |
| 0.09% | ALVO | ALVOTECH SA | -- | $80,977.88 | 14,804 | BPNTJ34 |
| 0.09% | HROW | HARROW INC | -- | $80,062.50 | 1,750 | BHNDW86 |
| 0.09% | STOK | STOKE THERAPEUTICS INC | -- | $80,015.04 | 2,592 | BJQ05Z6 |
| 0.09% | TRVI | TREVI THERAPEUTICS INC | -- | $77,587.20 | 5,760 | BJH9ZN0 |
| 0.09% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $76,368.42 | 2,754 | BCBVTX1 |
| 0.09% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $75,368.70 | 9,930 | 2100362 |
| 0.09% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $73,449.32 | 1,894 | BLCD809 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $71,385.90 | 1,490 | BX7RSN3 |
| 0.08% | ARDX | ARDELYX INC | -- | $68,160.04 | 11,398 | BN89V40 |
| 0.08% | NRIX | NURIX THERAPEUTICS INC | -- | $65,377.26 | 3,614 | BMVLGP2 |
| 0.08% | TSHA | TAYSHA GENE THERAPIES INC | -- | $65,155.10 | 12,902 | BNC1BX1 |
| 0.07% | NVCR | NOVOCURE LTD | -- | $64,037.68 | 5,288 | BYSS4X4 |
| 0.07% | GMAB | GENMAB A/S -SP ADR | -- | $62,940.42 | 1,983 | BBC9WC7 |
| 0.07% | SANA | SANA BIOTECHNOLOGY INC | -- | $62,770.68 | 12,236 | BMFJJ97 |
| 0.07% | RLAY | RELAY THERAPEUTICS INC | -- | $62,622.72 | 8,154 | BN2R582 |
| 0.07% | INVA | INNOVIVA INC | -- | $61,825.94 | 2,981 | BDDXF67 |
| 0.07% | INBX | INHIBRX BIOSCIENCES INC | -- | $61,376.42 | 686 | BNSP8K3 |
| 0.07% | FTRE | FORTREA HOLDINGS INC | -- | $61,146.56 | 4,294 | BRXYZ57 |
| 0.07% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $61,089.81 | 2,801 | BMFD115 |
| 0.07% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $60,395.94 | 5,546 | BRJZSK0 |
| 0.07% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $59,838.80 | 4,214 | BPCK358 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $58,867.23 | 2,199 | BNFWZS4 |
| 0.07% | ANAB | ANAPTYSBIO INC | -- | $58,763.75 | 1,325 | BDRW1L7 |
| 0.07% | XNCR | XENCOR INC | -- | $58,370.20 | 3,374 | BGCYWN8 |
| 0.07% | EYPT | EYEPOINT PHARMACEUTICALS INC | -- | $57,832.40 | 3,260 | BMGS7L1 |
| 0.07% | WVE | WAVE LIFE SCIENCES LTD | -- | $56,377.23 | 7,527 | BYZG9R0 |
| 0.06% | QURE | UNIQURE NV | -- | $55,351.35 | 2,595 | BJFSR88 |
| 0.06% | ORKA | ORUKA THERAPEUTICS INC | -- | $54,617.64 | 1,771 | BKVF0J2 |
| 0.06% | TYRA | TYRA BIOSCIENCES INC | -- | $54,201.50 | 2,521 | BMVNDH9 |
| 0.06% | SVRA | SAVARA INC | -- | $53,144.00 | 8,176 | BYXGN81 |
| 0.06% | NVAX | NOVAVAX INC | -- | $53,082.62 | 7,682 | BJDQXG4 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $52,975.44 | 1,371 | BKLCWZ3 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $51,064.50 | 5,770 | B8K7T65 |
| 0.06% | PCRX | PACIRA BIOSCIENCES INC | -- | $50,978.75 | 2,125 | B3X26D8 |
| 0.06% | ALMS | ALUMIS INC | -- | $50,951.84 | 4,582 | BPLQG36 |
| 0.06% | RAPP | RAPPORT THERAPEUTICS INC | -- | $50,946.50 | 1,727 | BR3T9B6 |
| 0.06% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $50,854.61 | 2,921 | BP7KZP7 |
| 0.06% | PGEN | PRECIGEN INC | -- | $50,734.80 | 14,093 | BKM5C84 |
| 0.06% | TNGX | TANGO THERAPEUTICS INC | -- | $50,682.69 | 5,263 | BP2P6L0 |
| 0.06% | ORIC | ORIC PHARMACEUTICALS INC | -- | $50,523.00 | 4,593 | BKVDFF7 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $50,317.04 | 14,134 | BL53SR3 |
| 0.06% | URGN | UROGEN PHARMA LTD | -- | $50,303.22 | 2,189 | BZ7PJQ1 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $49,723.38 | 7,638 | BLR7H87 |
| 0.06% | KURA | KURA ONCOLOGY INC | -- | $49,054.75 | 4,105 | BYZD465 |
| 0.06% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $48,915.90 | 3,355 | BJLKVS6 |
| 0.06% | NTLA | INTELLIA THERAPEUTICS INC | -- | $48,789.97 | 5,077 | BYZM6C2 |
| 0.06% | AVBP | ARRIVENT BIOPHARMA INC | -- | $47,355.42 | 1,918 | BMGTLY5 |
| 0.05% | JANX | JANUX THERAPEUTICS INC | -- | $46,921.42 | 2,842 | BMFX8Y7 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $46,412.82 | 4,674 | BMCR7V2 |
| 0.05% | MNMD | MIND MEDICINE MINDMED INC | -- | $44,534.10 | 3,606 | BPQYY97 |
| 0.05% | ARVN | ARVINAS INC | -- | $44,419.67 | 3,473 | BDZ30Q0 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $44,186.10 | 2,382 | BMNDK09 |
| 0.05% | ZLAB | ZAI LAB LTD-ADR | -- | $44,109.00 | 2,262 | BD9GVY0 |
| 0.05% | ERAS | ERASCA INC | -- | $43,873.59 | 13,417 | BNLYBF3 |
| 0.05% | VIR | VIR BIOTECHNOLOGY INC | -- | $42,705.00 | 6,570 | BK4PZ38 |
| 0.05% | KROS | KEROS THERAPEUTICS INC | -- | $41,644.80 | 1,920 | BM7V485 |
| 0.05% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $41,533.08 | 849 | BQD3J33 |
| 0.05% | PSNL | PERSONALIS INC | -- | $40,094.64 | 4,194 | BJQ0608 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $40,076.14 | 9,067 | BZ0QMB7 |
| 0.05% | MESO | MESOBLAST LTD- SPON ADR | -- | $39,903.71 | 2,233 | BQS7491 |
| 0.05% | GERN | GERON CORP | -- | $39,531.87 | 30,177 | 2370381 |
| 0.05% | REPL | REPLIMUNE GROUP INC | -- | $39,172.12 | 3,692 | BDDVW37 |
| 0.05% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $39,119.83 | 2,381 | BD06CS0 |
| 0.04% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $38,364.48 | 4,844 | BLB0YH0 |
| 0.04% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $37,711.08 | 963 | BL95N25 |
| 0.04% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $37,655.20 | 17,116 | BF0DMK7 |
| 0.04% | CRMD | CORMEDIX INC | -- | $37,287.36 | 3,531 | BJ0LT31 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $36,499.98 | 5,721 | BYVQJ96 |
| 0.04% | LENZ | LENZ THERAPEUTICS INC | -- | $36,045.28 | 1,349 | BQV0J03 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $35,573.01 | 9,537 | BBNBTD2 |
| 0.04% | OMER | OMEROS CORP | -- | $34,926.15 | 3,219 | B4NB858 |
| 0.04% | ATXS | ASTRIA THERAPEUTICS INC | -- | $34,523.10 | 2,670 | BMYRFN8 |
| 0.04% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $33,954.73 | 14,207 | B4N8MH9 |
| 0.04% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $32,913.25 | 3,805 | BFYQFJ2 |
| 0.04% | RGNX | REGENXBIO INC | -- | $31,557.68 | 2,398 | BZ0G875 |
| 0.04% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $31,055.25 | 3,525 | BYP80F1 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $30,933.54 | 8,271 | BPBJFM7 |
| 0.03% | CGEM | CULLINAN THERAPEUTICS INC | -- | $29,577.87 | 2,793 | BM90J52 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $28,184.22 | 2,546 | B91XRN2 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $26,733.36 | 7,682 | B3MZ6K5 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $26,310.61 | 2,693 | BMFK3H6 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $25,322.80 | 6,844 | BMCWKZ2 |
| 0.03% | ABSI | ABSCI CORP | -- | $25,321.34 | 7,073 | BN94K69 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $25,247.16 | 4,338 | BMC3HS7 |
| 0.03% | LXRX | LEXICON PHARMACEUTICALS INC | -- | $24,064.60 | 17,189 | BWFZX59 |
| 0.03% | ANNX | ANNEXON INC | -- | $23,935.12 | 5,192 | BMVV9R5 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $23,879.90 | 2,554 | BQ6C357 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $23,636.30 | 2,209 | BKLXFX5 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $23,133.76 | 2,656 | BLFBZ32 |
| 0.03% | LYEL | LYELL IMMUNOPHARMA INC | -- | $22,977.50 | 910 | BTNMG41 |
| 0.03% | ALT | ALTIMMUNE INC | -- | $21,877.00 | 4,175 | BFY7DC4 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $21,418.02 | 678 | B292NQ7 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $21,256.68 | 3,684 | BQHN6C7 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $20,999.40 | 3,387 | 2107437 |
| 0.02% | EOLS | EVOLUS INC | -- | $20,961.00 | 3,060 | BDRJH21 |
| 0.02% | HCM | HUTCHMED CHINA-ADR | -- | $20,874.96 | 1,468 | BYXV9H7 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $18,891.34 | 2,938 | BP81R42 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $18,576.00 | 1,800 | BP81RK8 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $17,872.80 | 4,062 | BYTYP72 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $17,629.20 | 885 | BPBPCG8 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $17,005.20 | 7,660 | BN4JN37 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $16,945.28 | 5,104 | BDFKQ07 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $15,958.80 | 2,046 | BSMLR16 |
| 0.02% | AMRN | AMARIN CORP PLC -ADR | -- | $15,762.62 | 953 | BN72KB0 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $15,555.60 | 2,235 | BL5B6Z1 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $15,440.88 | 2,184 | BKDQKM6 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $15,059.66 | 2,794 | B12W3P6 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $15,007.85 | 10,495 | BFZNYB7 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $14,977.60 | 4,048 | BMXNGZ6 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $14,775.20 | 1,012 | B9L5200 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $14,703.30 | 9,486 | BFMLGR4 |
| 0.02% | NGNE | NEUROGENE INC | -- | $13,709.28 | 676 | BS2F741 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $13,213.20 | 4,719 | BZC0D70 |
| 0.01% | PYXS | PYXIS ONCOLOGY INC | -- | $12,377.26 | 2,933 | BLBR8D5 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $12,148.80 | 2,531 | BP7L561 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $11,900.18 | 3,754 | BLN9Z50 |
| 0.01% | FHTX | FOGHORN THERAPEUTICS INC | -- | $11,658.64 | 2,674 | BMF7DT9 |
| 0.01% | OABI | OMNIAB INC | -- | $11,315.85 | 5,803 | BN13S71 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $11,226.44 | 2,623 | BY7RB53 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $10,292.26 | 4,253 | BZ8FPH3 |
| 0.01% | HUMA | HUMACYTE INC | -- | $9,213.93 | 7,491 | BMYTJP4 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $9,154.92 | 1,284 | BKC9SX3 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $8,989.89 | 3,367 | BKX9NQ0 |
| 0.01% | RNAC | CARTESIAN THERAPEUTICS INC | -- | $8,469.28 | 1,231 | BQB9HM8 |
| 0.01% | PEPG | PEPGEN INC | -- | $8,442.88 | 1,552 | BMTX3D7 |
| 0.01% | CDXS | CODEXIS INC | -- | $7,812.27 | 4,269 | B5LL2C2 |
| 0.01% | MXCT | MAXCYTE INC | -- | $7,413.21 | 5,043 | BKMQF66 |
| 0.01% | MRSN | MERSANA THERAPEUTICS INC | -- | $6,554.90 | 236 | BVPKH99 |
| 0.01% | NKTX | NKARTA INC | -- | $6,048.00 | 3,360 | BK80YJ8 |
| 0.01% | FATE | FATE THERAPEUTICS INC | -- | $5,891.40 | 5,455 | BCZS820 |
| 0.01% | ALEC | ALECTOR INC | -- | $5,841.36 | 4,788 | BJ4LDC4 |
| 0.01% | CLYM | CLIMB BIO INC | -- | $5,514.32 | 3,206 | BMW5LX6 |
| -- | MGNX | MACROGENICS INC | -- | $4,096.30 | 2,990 | BFDV8K0 |
| -- | ARTV | ARTIVA BIOTHERAPEUTICS INC | -- | $3,884.16 | 1,156 | BMF1LJ7 |
| -- | TVGN | TEVOGEN BIO HOLDINGS INC | -- | $3,727.18 | 9,304 | BPG5P75 |
| -- | ACRV | ACRIVON THERAPEUTICS INC | -- | $3,526.56 | 1,488 | BP2TPK4 |
| -- | PLRX | PLIANT THERAPEUTICS INC | -- | $3,513.84 | 2,904 | BMDWW66 |
| -- | -- | SUTRO BIOPHARMA INC COMMON STOCK USD 0.001 | -- | $3,464.00 | 400 | -- |
| -- | BMEA | BIOMEA FUSION INC | -- | $3,434.30 | 2,815 | BNKF6N0 |
| -- | TCRX | TSCAN THERAPEUTICS INC | -- | $2,679.48 | 2,481 | BNLYBJ7 |
| -- | QTTB | Q32 BIO INC | -- | $1,912.32 | 576 | BS2FKQ4 |
| -- | OKUR | ONKURE THERAPEUTICS INC-A | -- | $1,860.48 | 608 | BT7KGT6 |
| -- | APLT | APPLIED THERAPEUTICS INC | -- | $1,475.26 | 6,811 | BJL38Z1 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 35.60% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 30,616,871 | -- | 5,335 | -- |
| 33.41% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 28,740,261 | -- | 5,008 | -- |
| 26.00% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 22,364,376 | -- | 3,897 | -- |
| 16.57% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,255,353 | -- | 2,484 | -- |
| 15.34% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 13,193,662 | -- | 2,299 | -- |
| 4.22% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,632,705 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $26,791,384.66 | 26,791,385 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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