BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 2/28/2026
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 6.03% | 5.70% | 60.37% | 10.56% | 62.26% | 19.25% | -0.31% | 8.72% | 16.98% | 04/07/2010 |
| BIB Market Price | 6.05% | 5.51% | 60.28% | 10.49% | 62.05% | 19.26% | -0.28% | 8.72% | 16.98% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Net Assets $73,961,348
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time
- Distributions Quarterly
- Options Available Yes
Price
as of 3/30/2026- NAV
- NAV Change
- Market Price $74.69
- Market Price Change $+0.89
- Trading Volume (M) 6,680
- 30-Day Median Bid Ask Spread 0.25%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Net Assets $73,961,348
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time
- Distributions Quarterly
- Options Available Yes
Price
as of 3/30/2026- NAV
- NAV Change
- Market Price $74.69
- Market Price Change $+0.89
- Trading Volume (M) 6,680
- 30-Day Median Bid Ask Spread 0.25%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 12/31/2025
Holdings
as of 3/30/2026
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.70% | GILD | GILEAD SCIENCES INC | -- | $4,213,587.70 | 30,905 | 2369174 |
| 5.60% | AMGN | AMGEN INC | -- | $4,139,140.00 | 11,860 | 2023607 |
| 5.55% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $4,105,877.40 | 9,265 | 2931034 |
| 4.71% | REGN | REGENERON PHARMACEUTICALS | -- | $3,481,950.63 | 4,647 | 2730190 |
| 2.54% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $1,875,045.88 | 5,932 | B00FWN1 |
| 2.00% | INSM | INSMED INC | -- | $1,478,311.44 | 9,642 | 2614487 |
| 1.66% | BIIB | BIOGEN INC | -- | $1,231,209.48 | 6,564 | 2455965 |
| 1.56% | UTHR | UNITED THERAPEUTICS CORP | -- | $1,153,185.60 | 1,960 | 2430412 |
| 1.21% | ARGX | ARGENX SE - ADR | -- | $893,769.39 | 1,269 | BDVLM39 |
| 1.20% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $888,681.05 | 19,165 | BMVP7Y0 |
| 1.15% | MRNA | MODERNA INC | -- | $852,079.41 | 17,667 | BGSXTS3 |
| 1.14% | ROIV | ROIVANT SCIENCES LTD | -- | $845,568.97 | 32,017 | BMW4NZ9 |
| 1.12% | ILMN | ILLUMINA INC | -- | $826,461.21 | 6,841 | 2613990 |
| 1.11% | RVMD | REVOLUTION MEDICINES INC | -- | $821,874.15 | 8,865 | BL71K91 |
| 1.09% | INCY | INCYTE CORP | -- | $804,117.66 | 8,902 | 2471950 |
| 0.90% | VTRS | VIATRIS INC | -- | $667,530.72 | 51,507 | BMWS3X9 |
| 0.81% | BBIO | BRIDGEBIO PHARMA INC | -- | $601,559.28 | 8,673 | BK1KWG8 |
| 0.81% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $601,335.90 | 2,754 | BV9G6B8 |
| 0.80% | SMMT | SUMMIT THERAPEUTICS INC | -- | $588,968.28 | 34,686 | BMTVQS7 |
| 0.79% | MEDP | MEDPACE HOLDINGS INC | -- | $584,120.70 | 1,269 | BDCBC61 |
| 0.78% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $577,952.80 | 4,490 | 2623911 |
| 0.72% | IONS | IONIS PHARMACEUTICALS INC | -- | $535,922.80 | 7,390 | BDJ0LS6 |
| 0.70% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $518,984.18 | 1,027 | BD59BS7 |
| 0.69% | SNY | SANOFI-ADR | -- | $511,537.28 | 10,949 | 2964557 |
| 0.68% | GH | GUARDANT HEALTH INC | -- | $505,735.40 | 5,867 | BFXC911 |
| 0.68% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $504,395.10 | 2,754 | B4Q5ZN4 |
| 0.66% | EXEL | EXELIXIS INC | -- | $487,333.15 | 11,617 | 2576941 |
| 0.64% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $471,413.16 | 8,604 | 2437071 |
| 0.59% | BNTX | BIONTECH SE-ADR | -- | $434,434.00 | 5,096 | BK6H543 |
| 0.55% | ONC | BEONE MEDICINES LTD-ADR | -- | $406,234.40 | 1,430 | BYYWPW6 |
| 0.50% | AXSM | AXSOME THERAPEUTICS INC | -- | $367,384.50 | 2,289 | BYZR4X4 |
| 0.49% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $361,177.25 | 6,265 | BYQBFJ8 |
| 0.48% | PCVX | VAXCYTE INC | -- | $353,832.48 | 6,438 | BKPVGH6 |
| 0.47% | CYTK | CYTOKINETICS INC | -- | $346,901.73 | 5,509 | BBBSBJ5 |
| 0.47% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $344,167.80 | 1,245 | BQ721R4 |
| 0.45% | TEM | TEMPUS AI INC-CL A | -- | $329,257.27 | 7,771 | BSLSJJ0 |
| 0.44% | HALO | HALOZYME THERAPEUTICS INC | -- | $328,046.40 | 5,280 | 2975098 |
| 0.44% | KRYS | KRYSTAL BIOTECH INC | -- | $323,244.46 | 1,309 | BD6JX35 |
| 0.43% | NUVL | NUVALENT INC-A | -- | $316,661.28 | 3,274 | BMVBZD3 |
| 0.41% | IBRX | IMMUNITYBIO INC | -- | $306,300.06 | 45,991 | BNSP0B8 |
| 0.41% | ACLX | ARCELLX INC | -- | $300,238.32 | 2,616 | BPCJ1Q2 |
| 0.39% | KYMR | KYMERA THERAPEUTICS INC | -- | $290,181.48 | 3,651 | BMPRZV5 |
| 0.39% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $285,128.85 | 2,855 | BDCBCD8 |
| 0.38% | ABVX | ABIVAX SA-ADR | -- | $278,922.00 | 2,748 | BLC89B2 |
| 0.35% | COGT | COGENT BIOSCIENCES INC | -- | $256,966.79 | 7,261 | BLR6XK8 |
| 0.34% | TERN | TERNS PHARMACEUTICALS INC | -- | $251,550.16 | 4,757 | BMDJ0C9 |
| 0.33% | PTCT | PTC THERAPEUTICS INC | -- | $243,064.92 | 3,703 | B17VCN9 |
| 0.33% | CGON | CG ONCOLOGY INC | -- | $241,640.88 | 3,778 | BRBCSP4 |
| 0.32% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $237,242.10 | 2,699 | BJDX8Y8 |
| 0.32% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $235,998.75 | 3,055 | BF2YWG4 |
| 0.30% | ALKS | ALKERMES PLC | -- | $224,768.25 | 7,455 | B3P6D26 |
| 0.29% | IMVT | IMMUNOVANT INC | -- | $214,446.30 | 9,106 | BJRFSB7 |
| 0.29% | CAI | CARIS LIFE SCIENCES INC | -- | $212,680.70 | 12,622 | BT18HP9 |
| 0.28% | ERAS | ERASCA INC | -- | $206,919.00 | 13,850 | BNLYBF3 |
| 0.28% | XENE | XENON PHARMACEUTICALS INC | -- | $206,757.10 | 3,722 | BRJ3GY4 |
| 0.27% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $196,617.12 | 4,564 | BFZQ0L8 |
| 0.26% | APGE | APOGEE THERAPEUTICS INC | -- | $193,021.44 | 2,452 | BM9HHL5 |
| 0.26% | CRSP | CRISPR THERAPEUTICS AG | -- | $190,351.62 | 4,293 | BDHF4K6 |
| 0.23% | LGND | LIGAND PHARMACEUTICALS | -- | $171,642.24 | 891 | 2501578 |
| 0.23% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $168,208.20 | 14,076 | BFNF1D6 |
| 0.22% | INDV | INDIVIOR PHARMACEUTICALS INC | -- | $160,995.32 | 5,594 | BTZRLN8 |
| 0.22% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $160,679.82 | 7,626 | 2713317 |
| 0.22% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $160,520.68 | 4,684 | BDD19F8 |
| 0.22% | SYRE | SPYRE THERAPEUTICS INC | -- | $159,560.46 | 3,513 | BQBBDY8 |
| 0.21% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $153,130.90 | 3,485 | BQS9486 |
| 0.20% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $150,814.86 | 5,142 | BP8JSP4 |
| 0.20% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $147,580.58 | 5,351 | BLB0YQ9 |
| 0.20% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $145,283.44 | 4,798 | BKY5JZ8 |
| 0.17% | DNLI | DENALI THERAPEUTICS INC | -- | $128,277.60 | 7,095 | BD2B4V0 |
| 0.17% | TARS | TARSUS PHARMACEUTICALS INC | -- | $127,348.76 | 1,903 | BMH5RL1 |
| 0.17% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $126,582.75 | 2,565 | B72ZBG4 |
| 0.17% | DYN | DYNE THERAPEUTICS INC | -- | $125,867.85 | 7,365 | BN15WD1 |
| 0.17% | IDYA | IDEAYA BIOSCIENCES INC | -- | $123,567.05 | 3,929 | BK0VHF6 |
| 0.16% | VERA | VERA THERAPEUTICS INC | -- | $121,615.20 | 3,192 | BL55460 |
| 0.16% | TWST | TWIST BIOSCIENCE CORP | -- | $118,618.92 | 2,742 | BGKG6G7 |
| 0.16% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $118,253.52 | 5,544 | BKX9VD3 |
| 0.16% | TNGX | TANGO THERAPEUTICS INC | -- | $115,740.25 | 6,025 | BP2P6L0 |
| 0.15% | ALMS | ALUMIS INC | -- | $114,287.55 | 5,655 | BPLQG36 |
| 0.15% | TVTX | TRAVERE THERAPEUTICS INC | -- | $114,152.82 | 4,127 | BLFGJD5 |
| 0.15% | VCYT | VERACYTE INC | -- | $108,214.20 | 3,555 | BFTWZY0 |
| 0.14% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $106,029.00 | 11,220 | 2100362 |
| 0.14% | TXG | 10X GENOMICS INC-CLASS A | -- | $104,279.84 | 5,264 | BKS3RS7 |
| 0.14% | IRON | DISC MEDICINE INC | -- | $103,751.46 | 1,707 | BMGJZJ8 |
| 0.13% | BEAM | BEAM THERAPEUTICS INC | -- | $99,798.30 | 4,557 | BK6L288 |
| 0.13% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $98,981.82 | 4,621 | BLB0YH0 |
| 0.13% | ORKA | ORUKA THERAPEUTICS INC | -- | $98,550.80 | 2,165 | BKVF0J2 |
| 0.13% | APLS | APELLIS PHARMACEUTICALS INC | -- | $97,720.62 | 5,718 | BYTQ6X1 |
| 0.13% | ADMA | ADMA BIOLOGICS INC | -- | $97,484.10 | 10,654 | B9NSBM2 |
| 0.13% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $97,183.04 | 2,656 | BMFD115 |
| 0.13% | SRPT | SAREPTA THERAPEUTICS INC | -- | $96,010.24 | 4,688 | B8DPDT7 |
| 0.13% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $93,822.10 | 2,053 | BRXB0C0 |
| 0.12% | KOD | KODIAK SCIENCES INC | -- | $91,891.80 | 2,730 | BFXC933 |
| 0.12% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $88,683.60 | 3,945 | BN7Q7R7 |
| 0.12% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $88,510.80 | 6,888 | BJ5FZ74 |
| 0.11% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $83,433.90 | 4,323 | BJ62Z18 |
| 0.11% | MLYS | MINERALYS THERAPEUTICS INC | -- | $83,225.40 | 3,540 | BP9N0G0 |
| 0.11% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $83,153.04 | 5,948 | BFWLC09 |
| 0.11% | TYRA | TYRA BIOSCIENCES INC | -- | $82,590.20 | 2,387 | BMVNDH9 |
| 0.11% | GRAL | GRAIL INC | -- | $81,746.70 | 1,743 | BSLSSX7 |
| 0.11% | STOK | STOKE THERAPEUTICS INC | -- | $81,172.35 | 2,555 | BJQ05Z6 |
| 0.11% | ZYME | ZYMEWORKS INC | -- | $81,055.08 | 3,348 | BPCQZY9 |
| 0.11% | PHVS | PHARVARIS NV | -- | $78,213.14 | 2,866 | BMZ2X38 |
| 0.11% | DFTX | DEFINIUM THERAPEUTICS INC | -- | $78,050.00 | 4,460 | BV2DHY6 |
| 0.10% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $77,607.81 | 2,621 | BCBVTX1 |
| 0.10% | INVA | INNOVIVA INC | -- | $75,900.83 | 3,313 | BDDXF67 |
| 0.10% | RLAY | RELAY THERAPEUTICS INC | -- | $74,753.25 | 7,995 | BN2R582 |
| 0.10% | GMAB | GENMAB A/S -SP ADR | -- | $74,364.57 | 2,879 | BBC9WC7 |
| 0.10% | ANIP | ANI PHARMACEUTICALS INC | -- | $73,931.13 | 1,003 | BCDWBX6 |
| 0.10% | SION | SIONNA THERAPEUTICS INC | -- | $73,210.02 | 1,997 | BQKXDX4 |
| 0.10% | OCUL | OCULAR THERAPEUTIX INC | -- | $72,068.60 | 9,739 | BNZB1X8 |
| 0.09% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $69,617.20 | 2,588 | BKSGZN7 |
| 0.09% | VCEL | VERICEL CORP | -- | $69,379.05 | 2,271 | BSBMN89 |
| 0.09% | ANAB | ANAPTYSBIO INC | -- | $68,683.60 | 1,240 | BDRW1L7 |
| 0.09% | NRIX | NURIX THERAPEUTICS INC | -- | $67,482.00 | 4,600 | BMVLGP2 |
| 0.09% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $66,311.16 | 23,349 | BM9FJ13 |
| 0.09% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $65,362.56 | 3,776 | BMX9K07 |
| 0.09% | TRVI | TREVI THERAPEUTICS INC | -- | $64,185.84 | 5,736 | BJH9ZN0 |
| 0.08% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $62,689.88 | 4,913 | BPCK358 |
| 0.08% | MAZE | MAZE THERAPEUTICS INC | -- | $62,458.53 | 2,153 | BSRK699 |
| 0.08% | NTLA | INTELLIA THERAPEUTICS INC | -- | $61,558.60 | 5,284 | BYZM6C2 |
| 0.08% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $61,180.96 | 18,428 | BF0DMK7 |
| 0.08% | ARDX | ARDELYX INC | -- | $60,883.50 | 10,970 | BN89V40 |
| 0.08% | VIR | VIR BIOTECHNOLOGY INC | -- | $59,482.26 | 7,031 | BK4PZ38 |
| 0.08% | RAPP | RAPPORT THERAPEUTICS INC | -- | $59,035.08 | 2,132 | BR3T9B6 |
| 0.08% | NVAX | NOVAVAX INC | -- | $58,959.92 | 7,288 | BJDQXG4 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $57,437.69 | 1,961 | BLCD809 |
| 0.08% | WVE | WAVE LIFE SCIENCES LTD | -- | $55,747.02 | 8,421 | BYZG9R0 |
| 0.07% | ATAI | ATAIBECKLEY INC | -- | $55,243.20 | 16,248 | BWJDYK1 |
| 0.07% | HROW | HARROW INC | -- | $55,211.40 | 1,658 | BHNDW86 |
| 0.07% | ORIC | ORIC PHARMACEUTICALS INC | -- | $54,733.10 | 4,490 | BKVDFF7 |
| 0.07% | MBX | MBX BIOSCIENCES INC | -- | $54,082.28 | 2,009 | BQXJKH2 |
| 0.07% | BCAX | BICARA THERAPEUTICS INC | -- | $53,959.36 | 2,834 | BQB42F1 |
| 0.07% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $52,972.83 | 3,411 | BP7KZP7 |
| 0.07% | NVCR | NOVOCURE LTD | -- | $52,732.40 | 5,090 | BYSS4X4 |
| 0.07% | PGEN | PRECIGEN INC | -- | $51,441.00 | 15,828 | BKM5C84 |
| 0.07% | TSHA | TAYSHA GENE THERAPIES INC | -- | $49,869.71 | 12,253 | BNC1BX1 |
| 0.07% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $49,499.60 | 3,694 | BYP80F1 |
| 0.07% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $49,242.05 | 923 | BL95N25 |
| 0.07% | ALVO | ALVOTECH SA | -- | $48,613.04 | 14,776 | BPNTJ34 |
| 0.07% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $48,110.70 | 3,585 | BMZ4LN0 |
| 0.06% | SEPN | SEPTERNA INC | -- | $46,669.90 | 2,003 | BQNKXX2 |
| 0.06% | SVRA | SAVARA INC | -- | $45,970.15 | 9,103 | BYXGN81 |
| 0.06% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $45,457.79 | 1,421 | BX7RSN3 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $44,483.36 | 13,562 | BL53SR3 |
| 0.06% | ZBIO | ZENAS BIOPHARMA INC | -- | $44,377.88 | 2,435 | BQB42H3 |
| 0.06% | EYPT | EYEPOINT INC | -- | $43,892.40 | 3,704 | BMGS7L1 |
| 0.06% | PCRX | PACIRA BIOSCIENCES INC | -- | $42,118.70 | 1,810 | B3X26D8 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $41,563.20 | 7,422 | BLR7H87 |
| 0.06% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $41,511.96 | 2,261 | BD06CS0 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $41,254.92 | 5,457 | B8K7T65 |
| 0.06% | QURE | UNIQURE NV | -- | $41,052.51 | 2,787 | BJFSR88 |
| 0.05% | GERN | GERON CORP | -- | $40,263.96 | 28,556 | 2370381 |
| 0.05% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $38,997.38 | 2,029 | BNFWZS4 |
| 0.05% | INBX | INHIBRX BIOSCIENCES INC | -- | $38,981.88 | 651 | BNSP8K3 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $38,805.47 | 1,847 | BMGTLY5 |
| 0.05% | XNCR | XENCOR INC | -- | $37,239.35 | 3,281 | BGCYWN8 |
| 0.05% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $37,107.72 | 3,524 | BJLKVS6 |
| 0.05% | FTRE | FORTREA HOLDINGS INC | -- | $37,103.21 | 4,183 | BRXYZ57 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $36,997.20 | 8,604 | BZ0QMB7 |
| 0.05% | GHRS | GH RESEARCH PLC | -- | $36,158.25 | 2,775 | BP6C0S2 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $35,581.00 | 2,093 | BZ7PJQ1 |
| 0.05% | CGEM | CULLINAN THERAPEUTICS INC | -- | $35,469.06 | 2,643 | BM90J52 |
| 0.05% | JANX | JANUX THERAPEUTICS INC | -- | $35,467.66 | 2,722 | BMFX8Y7 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $34,594.42 | 2,267 | BMNDK09 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $34,565.75 | 4,423 | BMCR7V2 |
| 0.05% | MESO | MESOBLAST LTD- SPON ADR | -- | $33,654.54 | 2,342 | BQS7491 |
| 0.05% | CTMX | CYTOMX THERAPEUTICS INC | -- | $33,423.39 | 7,579 | BYWVTY5 |
| 0.04% | MNKD | MANNKIND CORP | -- | $32,665.71 | 13,783 | BF081J4 |
| 0.04% | ANNX | ANNEXON INC | -- | $32,116.00 | 6,475 | BMVV9R5 |
| 0.04% | SANA | SANA BIOTECHNOLOGY INC | -- | $31,934.88 | 11,916 | BMFJJ97 |
| 0.04% | CSTL | CASTLE BIOSCIENCES INC | -- | $31,321.50 | 1,330 | BKLCWZ3 |
| 0.04% | OMER | OMEROS CORP | -- | $31,107.51 | 3,171 | B4NB858 |
| 0.04% | BIOA | BIOAGE LABS INC | -- | $30,773.52 | 1,944 | BT9K6D8 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $30,085.16 | 3,892 | BYZD465 |
| 0.04% | PSNL | PERSONALIS INC | -- | $29,209.44 | 4,681 | BJQ0608 |
| 0.04% | ARVN | ARVINAS INC | -- | $29,135.16 | 2,862 | BDZ30Q0 |
| 0.04% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $29,124.00 | 3,600 | BFYQFJ2 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $28,125.22 | 10,694 | BBNBTD2 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $27,364.05 | 1,533 | BD9GVY0 |
| 0.04% | VOR | VOR BIOPHARMA INC | -- | $27,312.60 | 1,858 | BRJJYT3 |
| 0.04% | ETON | ETON PHARMACEUTICALS INC | -- | $27,073.42 | 1,199 | BGL0JK3 |
| 0.04% | REPL | REPLIMUNE GROUP INC | -- | $26,596.80 | 3,694 | BDDVW37 |
| 0.04% | DSGN | DESIGN THERAPEUTICS INC | -- | $26,422.76 | 2,548 | BMFK3H6 |
| 0.03% | PRME | PRIME MEDICINE INC | -- | $25,436.25 | 8,075 | BPBJFM7 |
| 0.03% | TECX | TECTONIC THERAPEUTIC INC | -- | $24,250.80 | 840 | BPBPCG8 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $23,520.86 | 7,282 | B3MZ6K5 |
| 0.03% | CRMD | CORMEDIX INC | -- | $23,152.68 | 3,524 | BJ0LT31 |
| 0.03% | SLDB | SOLID BIOSCIENCES INC | -- | $22,624.14 | 3,486 | BQHN6C7 |
| 0.03% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $22,317.66 | 10,053 | BFZNYB7 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $22,274.00 | 2,408 | B91XRN2 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $22,112.80 | 4,220 | BMC3HS7 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $22,099.26 | 2,517 | BLFBZ32 |
| 0.03% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $22,050.32 | 5,458 | BYVQJ96 |
| 0.03% | UPB | UPSTREAM BIO INC | -- | $21,230.04 | 2,418 | BRCFFK6 |
| 0.03% | LRMR | LARIMAR THERAPEUTICS INC | -- | $20,933.67 | 4,857 | BMXNGZ6 |
| 0.03% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $20,910.36 | 813 | BQD3J33 |
| 0.03% | KMDA | KAMADA LTD | -- | $20,828.67 | 2,581 | B2Q9833 |
| 0.03% | TRDA | ENTRADA THERAPEUTICS INC | -- | $20,162.01 | 1,713 | BP81RK8 |
| 0.03% | FULC | FULCRUM THERAPEUTICS INC | -- | $19,601.82 | 2,979 | BJDX8Z9 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $19,556.74 | 2,282 | BKLXFX5 |
| 0.03% | KYTX | KYVERNA THERAPEUTICS INC | -- | $19,374.48 | 2,556 | BSMLR16 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $19,149.76 | 664 | B292NQ7 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $18,861.12 | 6,549 | BMCWKZ2 |
| 0.03% | ACRS | ACLARIS THERAPEUTICS INC | -- | $18,828.55 | 5,395 | BYV2W40 |
| 0.03% | ABSI | ABSCI CORP | -- | $18,563.76 | 6,726 | BN94K69 |
| 0.02% | LYEL | LYELL IMMUNOPHARMA INC | -- | $18,344.79 | 951 | BTNMG41 |
| 0.02% | AVIR | ATEA PHARMACEUTICALS INC | -- | $17,754.60 | 3,495 | BLN9Z50 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $17,649.10 | 2,654 | B12W3P6 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $17,614.20 | 2,841 | BP81R42 |
| 0.02% | RGNX | REGENXBIO INC | -- | $17,591.28 | 2,264 | BZ0G875 |
| 0.02% | LXEO | LEXEO THERAPEUTICS INC | -- | $17,206.55 | 3,265 | BQ6C357 |
| 0.02% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $17,021.34 | 13,509 | B4N8MH9 |
| 0.02% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $16,970.52 | 1,362 | BPRBTY7 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $16,853.04 | 3,204 | 2107437 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $16,735.81 | 4,858 | BDFKQ07 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $16,133.76 | 5,602 | BFY7DC4 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $15,821.82 | 1,299 | B9L5200 |
| 0.02% | IVVD | INVIVYD INC | -- | $14,751.24 | 12,396 | BM8NHS1 |
| 0.02% | CADL | CANDEL THERAPEUTICS INC | -- | $14,649.60 | 3,270 | BP0TQC5 |
| 0.02% | KROS | KEROS THERAPEUTICS INC | -- | $14,556.84 | 1,363 | BM7V485 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $14,426.75 | 7,475 | BN4JN37 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $14,005.60 | 2,870 | BMVBZF5 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $13,951.88 | 2,276 | B7F2TY6 |
| 0.02% | NGNE | NEUROGENE INC | -- | $13,355.60 | 692 | BS2F741 |
| 0.02% | PEPG | PEPGEN INC | -- | $13,011.48 | 3,076 | BMTX3D7 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $11,691.72 | 4,146 | BYTYP72 |
| 0.02% | LENZ | LENZ THERAPEUTICS INC | -- | $11,597.71 | 1,399 | BQV0J03 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $11,580.40 | 2,620 | BMF7DT9 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $11,522.56 | 4,501 | BZC0D70 |
| 0.02% | EOLS | EVOLUS INC | -- | $11,422.06 | 2,899 | BDRJH21 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $11,395.71 | 8,973 | BFMLGR4 |
| 0.02% | NBP | NOVABRIDGE BIOSCIENCES | -- | $11,247.04 | 5,021 | BKRRKY7 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $10,699.20 | 6,687 | BRK0149 |
| 0.01% | CABA | CABALETTA BIO INC | -- | $10,635.82 | 4,306 | BK5MWR1 |
| 0.01% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $10,458.00 | 2,100 | BL5B6Z1 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $10,276.75 | 2,525 | BPRB2N7 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $10,255.40 | 4,364 | BKX9NQ0 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $10,205.19 | 2,637 | BY7RB53 |
| 0.01% | OABI | OMNIAB INC | -- | $10,044.84 | 6,439 | BN13S71 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $9,736.18 | 4,366 | BZ8FPH3 |
| 0.01% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $8,996.82 | 2,073 | BKDQKM6 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $8,769.90 | 1,271 | BKC9SX3 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $7,191.32 | 4,181 | BNYJR68 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $6,449.85 | 8,742 | BNR5QT9 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $6,415.92 | 2,394 | BP7L561 |
| 0.01% | LFCR | LIFECORE BIOMEDICAL INC | -- | $6,348.25 | 1,675 | 2517058 |
| 0.01% | MENS | JYONG BIOTECH LTD | -- | $6,308.00 | 3,320 | BPTK6Z2 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $6,306.30 | 1,386 | BP2NYN2 |
| 0.01% | CDXS | CODEXIS INC | -- | $6,142.32 | 4,041 | B5LL2C2 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $6,011.52 | 9,696 | BNNXX52 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $5,174.47 | 2,549 | BKTV702 |
| 0.01% | HUMA | HUMACYTE INC | -- | $4,959.66 | 8,633 | BMYTJP4 |
| -- | AARD | AARDVARK THERAPEUTICS INC | -- | $3,541.72 | 973 | BTXQTX3 |
| -- | PYXS | PYXIS ONCOLOGY INC | -- | $3,538.22 | 2,786 | BLBR8D5 |
| -- | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $3,329.41 | 4,363 | BNNXX18 |
| -- | GOSS | GOSSAMER BIO INC | -- | $3,313.28 | 10,354 | BJ0CK86 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $24.10 | 01 | BTFHQP5 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| 32.34% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 23,918,157 | -- | 4,283 | -- |
| 28.04% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 20,735,026 | -- | 3,713 | -- |
| 27.95% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 20,673,597 | -- | 3,702 | -- |
| 19.93% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 14,737,337 | -- | 2,639 | -- |
| 15.03% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 11,113,036 | -- | 1,990 | -- |
| 4.78% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,534,951 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $20,748,958.71 | 20,748,959 | -- |
Index
as of 12/31/2025
- Total Number of Companies262
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$7.32 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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