BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 9/30/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 10/30/2025- NAV $69.84
- NAV Change $+0.98
- Market Price $69.84
- Market Price Change $+0.98
- Trading Volume (M) 9,992
- 30-Day Median Bid Ask Spread 0.28%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 10/30/2025- NAV $69.84
- NAV Change $+0.98
- Market Price $69.84
- Market Price Change $+0.98
- Trading Volume (M) 9,992
- 30-Day Median Bid Ask Spread 0.28%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 10/30/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 4.94% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $3,345,683.52 | 7,968 | 2931034 |
| 4.82% | GILD | GILEAD SCIENCES INC | -- | $3,266,575.20 | 27,580 | 2369174 |
| 4.67% | AMGN | AMGEN INC | -- | $3,162,068.00 | 10,829 | 2023607 |
| 3.76% | REGN | REGENERON PHARMACEUTICALS | -- | $2,544,215.60 | 3,890 | 2730190 |
| 3.25% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,200,596.20 | 4,895 | B00FWN1 |
| 2.37% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $1,605,465.32 | 19,498 | 2989044 |
| 2.28% | INSM | INSMED INC | -- | $1,545,796.98 | 7,959 | 2614487 |
| 1.40% | ARGX | ARGENX SE - ADR | -- | $945,875.08 | 1,153 | BDVLM39 |
| 1.22% | BIIB | BIOGEN INC | -- | $825,847.20 | 5,520 | 2455965 |
| 1.14% | UTHR | UNITED THERAPEUTICS CORP | -- | $772,361.59 | 1,703 | 2430412 |
| 1.00% | INCY | INCYTE CORP | -- | $680,814.27 | 7,353 | 2471950 |
| 0.91% | MEDP | MEDPACE HOLDINGS INC | -- | $613,451.09 | 1,057 | BDCBC61 |
| 0.89% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $601,272.38 | 16,277 | BMVP7Y0 |
| 0.85% | ILMN | ILLUMINA INC | -- | $572,970.87 | 5,787 | 2613990 |
| 0.81% | TEM | TEMPUS AI INC | -- | $547,987.04 | 6,352 | BSLSJJ0 |
| 0.77% | SMMT | SUMMIT THERAPEUTICS INC | -- | $521,342.16 | 27,969 | BMTVQS7 |
| 0.76% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $515,441.36 | 3,734 | 2623911 |
| 0.76% | SNY | SANOFI-ADR | -- | $514,595.88 | 10,102 | 2964557 |
| 0.74% | ROIV | ROIVANT SCIENCES LTD | -- | $503,440.96 | 25,712 | BMW4NZ9 |
| 0.69% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $466,699.61 | 2,291 | BV9G6B8 |
| 0.67% | BBIO | BRIDGEBIO PHARMA INC | -- | $456,137.26 | 7,198 | BK1KWG8 |
| 0.67% | VTRS | VIATRIS INC | -- | $454,772.92 | 43,897 | BMWS3X9 |
| 0.66% | IONS | IONIS PHARMACEUTICALS INC | -- | $445,168.34 | 6,002 | BDJ0LS6 |
| 0.64% | GH | GUARDANT HEALTH INC | -- | $433,864.95 | 4,695 | BFXC911 |
| 0.61% | RVMD | REVOLUTION MEDICINES INC | -- | $414,385.93 | 7,039 | BL71K91 |
| 0.61% | MRNA | MODERNA INC | -- | $412,222.86 | 14,649 | BGSXTS3 |
| 0.59% | BNTX | BIONTECH SE-ADR | -- | $396,385.29 | 3,787 | BK6H543 |
| 0.58% | EXEL | EXELIXIS INC | -- | $394,695.84 | 10,136 | 2576941 |
| 0.58% | ONC | BEONE MEDICINES LTD-ADR | -- | $389,898.30 | 1,265 | BYYWPW6 |
| 0.55% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $375,309.30 | 7,230 | 2437071 |
| 0.53% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $358,689.28 | 839 | BD59BS7 |
| 0.50% | RNA | AVIDITY BIOSCIENCES INC | -- | $337,578.36 | 4,844 | BMWHPY1 |
| 0.46% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $311,309.20 | 2,284 | B4Q5ZN4 |
| 0.42% | HALO | HALOZYME THERAPEUTICS INC | -- | $284,630.52 | 4,404 | 2975098 |
| 0.41% | CYTK | CYTOKINETICS INC | -- | $280,436.25 | 4,505 | BBBSBJ5 |
| 0.41% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $279,636.81 | 2,501 | BF2YWG4 |
| 0.40% | MRUS | MERUS NV | -- | $270,730.88 | 2,848 | BZBY005 |
| 0.37% | AXSM | AXSOME THERAPEUTICS INC | -- | $250,055.70 | 1,878 | BYZR4X4 |
| 0.36% | NUVL | NUVALENT INC-A | -- | $246,406.70 | 2,510 | BMVBZD3 |
| 0.33% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $220,223.55 | 5,205 | BYQBFJ8 |
| 0.32% | PCVX | VAXCYTE INC | -- | $218,738.00 | 4,888 | BKPVGH6 |
| 0.31% | CRSP | CRISPR THERAPEUTICS AG | -- | $209,206.40 | 3,424 | BDHF4K6 |
| 0.30% | KRYS | KRYSTAL BIOTECH INC | -- | $206,097.20 | 1,090 | BD6JX35 |
| 0.30% | PTCT | PTC THERAPEUTICS INC | -- | $203,717.01 | 2,991 | B17VCN9 |
| 0.28% | ALKS | ALKERMES PLC | -- | $191,577.12 | 6,216 | B3P6D26 |
| 0.27% | ACLX | ARCELLX INC | -- | $182,700.00 | 2,088 | BPCJ1Q2 |
| 0.27% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $182,324.70 | 2,342 | BDCBCD8 |
| 0.24% | KYMR | KYMERA THERAPEUTICS INC | -- | $165,396.48 | 2,692 | BMPRZV5 |
| 0.24% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $164,211.52 | 4,241 | BP8JSP4 |
| 0.24% | AKRO | AKERO THERAPEUTICS INC | -- | $163,431.12 | 3,012 | BK7Y2V9 |
| 0.24% | IMVT | IMMUNOVANT INC | -- | $162,918.48 | 6,564 | BJRFSB7 |
| 0.23% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $159,192.00 | 792 | BQ721R4 |
| 0.23% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $153,644.00 | 3,550 | BDD19F8 |
| 0.21% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $144,467.22 | 6,353 | 2713317 |
| 0.21% | QURE | UNIQURE NV | -- | $140,198.76 | 2,066 | BJFSR88 |
| 0.20% | LGND | LIGAND PHARMACEUTICALS | -- | $138,050.28 | 738 | 2501578 |
| 0.20% | ADMA | ADMA BIOLOGICS INC | -- | $137,185.68 | 8,984 | B9NSBM2 |
| 0.20% | INDV | INDIVIOR PLC | -- | $136,823.61 | 4,697 | BP0BQQ5 |
| 0.20% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $136,602.40 | 1,892 | BJDX8Y8 |
| 0.19% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $127,631.93 | 3,629 | BJ62Z18 |
| 0.19% | DYN | DYNE THERAPEUTICS INC | -- | $126,157.35 | 5,357 | BN15WD1 |
| 0.18% | XENE | XENON PHARMACEUTICALS INC | -- | $123,871.01 | 2,903 | BRJ3GY4 |
| 0.18% | GRAL | GRAIL INC | -- | $123,690.55 | 1,357 | BSLSSX7 |
| 0.18% | CGON | CG ONCOLOGY INC | -- | $121,931.37 | 2,871 | BRBCSP4 |
| 0.18% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $119,271.50 | 2,111 | B72ZBG4 |
| 0.17% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $118,250.00 | 11,825 | BFNF1D6 |
| 0.17% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $112,488.88 | 4,514 | BKX9VD3 |
| 0.17% | IRON | DISC MEDICINE INC | -- | $112,246.75 | 1,309 | BMGJZJ8 |
| 0.16% | TARS | TARSUS PHARMACEUTICALS INC | -- | $109,646.40 | 1,590 | BMH5RL1 |
| 0.16% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $106,319.40 | 3,620 | BFZQ0L8 |
| 0.15% | VCYT | VERACYTE INC | -- | $104,647.46 | 2,962 | BFTWZY0 |
| 0.15% | IDYA | IDEAYA BIOSCIENCES INC | -- | $104,280.00 | 3,300 | BK0VHF6 |
| 0.15% | FOLD | AMICUS THERAPEUTICS INC | -- | $103,293.40 | 11,606 | B19FQ48 |
| 0.15% | MLYS | MINERALYS THERAPEUTICS INC | -- | $102,635.52 | 2,496 | BP9N0G0 |
| 0.15% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $102,232.50 | 3,170 | BMX9K07 |
| 0.15% | TVTX | TRAVERE THERAPEUTICS INC | -- | $99,535.05 | 3,357 | BLFGJD5 |
| 0.15% | APLS | APELLIS PHARMACEUTICALS INC | -- | $98,571.15 | 4,755 | BYTQ6X1 |
| 0.14% | APGE | APOGEE THERAPEUTICS INC | -- | $97,285.44 | 1,736 | BM9HHL5 |
| 0.14% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $96,945.03 | 5,733 | BJ5FZ74 |
| 0.14% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $94,477.84 | 2,188 | BCBVTX1 |
| 0.14% | ALVO | ALVOTECH SA | -- | $92,394.40 | 11,785 | BPNTJ34 |
| 0.13% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $90,902.85 | 16,089 | BM9FJ13 |
| 0.13% | BEAM | BEAM THERAPEUTICS INC | -- | $90,654.20 | 3,809 | BK6L288 |
| 0.13% | DNLI | DENALI THERAPEUTICS INC | -- | $90,171.90 | 5,505 | BD2B4V0 |
| 0.13% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $87,879.96 | 3,612 | BLB0YQ9 |
| 0.13% | SRPT | SAREPTA THERAPEUTICS INC | -- | $85,536.75 | 3,679 | B8DPDT7 |
| 0.13% | COGT | COGENT BIOSCIENCES INC | -- | $85,248.39 | 5,259 | BLR6XK8 |
| 0.12% | IBRX | IMMUNITYBIO INC | -- | $83,994.76 | 35,591 | BNSP0B8 |
| 0.11% | OCUL | OCULAR THERAPEUTIX INC | -- | $77,432.82 | 6,551 | BNZB1X8 |
| 0.11% | ANIP | ANI PHARMACEUTICALS INC | -- | $75,106.81 | 817 | BCDWBX6 |
| 0.11% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $74,231.92 | 3,976 | BKY5JZ8 |
| 0.11% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $72,301.68 | 2,244 | BQS9486 |
| 0.11% | VERA | VERA THERAPEUTICS INC | -- | $71,326.68 | 2,404 | BL55460 |
| 0.10% | TWST | TWIST BIOSCIENCE CORP | -- | $70,818.24 | 2,272 | BGKG6G7 |
| 0.10% | AVDL | AVADEL PHARMACEUTICALS | -- | $68,823.65 | 3,655 | BDGMC59 |
| 0.10% | VCEL | VERICEL CORP | -- | $65,607.00 | 1,900 | BSBMN89 |
| 0.10% | STOK | STOKE THERAPEUTICS INC | -- | $65,428.80 | 2,064 | BJQ05Z6 |
| 0.10% | JANX | JANUX THERAPEUTICS INC | -- | $64,489.62 | 2,262 | BMFX8Y7 |
| 0.09% | MNKD | MANNKIND CORP | -- | $64,124.70 | 11,554 | BF081J4 |
| 0.09% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $62,597.40 | 2,166 | BKSGZN7 |
| 0.09% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $61,043.73 | 1,637 | BRXB0C0 |
| 0.09% | ABCL | ABCELLERA BIOLOGICS INC | -- | $60,316.08 | 11,253 | BL53SR3 |
| 0.09% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $60,078.84 | 4,957 | BFWLC09 |
| 0.09% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $59,046.51 | 6,081 | BLR7H87 |
| 0.08% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $57,304.00 | 7,904 | 2100362 |
| 0.08% | SYRE | SPYRE THERAPEUTICS INC | -- | $55,191.50 | 2,275 | BQBBDY8 |
| 0.08% | ZYME | ZYMEWORKS INC | -- | $54,109.60 | 2,830 | BPCQZY9 |
| 0.08% | NVCR | NOVOCURE LTD | -- | $53,959.38 | 4,209 | BYSS4X4 |
| 0.08% | TXG | 10X GENOMICS INC-CLASS A | -- | $53,591.52 | 4,308 | BKS3RS7 |
| 0.08% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $53,477.07 | 2,231 | BMFD115 |
| 0.08% | HROW | HARROW INC | -- | $52,321.08 | 1,393 | BHNDW86 |
| 0.08% | NVAX | NOVAVAX INC | -- | $51,557.88 | 6,116 | BJDQXG4 |
| 0.08% | TRVI | TREVI THERAPEUTICS INC | -- | $51,214.45 | 4,585 | BJH9ZN0 |
| 0.07% | TSHA | TAYSHA GENE THERAPIES INC | -- | $50,435.52 | 10,272 | BNC1BX1 |
| 0.07% | WVE | WAVE LIFE SCIENCES LTD | -- | $49,733.60 | 5,992 | BYZG9R0 |
| 0.07% | NTLA | INTELLIA THERAPEUTICS INC | -- | $49,562.87 | 4,041 | BYZM6C2 |
| 0.07% | ORIC | ORIC PHARMACEUTICALS INC | -- | $48,771.04 | 3,656 | BKVDFF7 |
| 0.07% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $48,542.52 | 1,508 | BLCD809 |
| 0.07% | SANA | SANA BIOTECHNOLOGY INC | -- | $47,735.80 | 9,742 | BMFJJ97 |
| 0.07% | RLAY | RELAY THERAPEUTICS INC | -- | $47,651.28 | 6,492 | BN2R582 |
| 0.07% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $47,179.90 | 3,358 | BPCK358 |
| 0.07% | ZLAB | ZAI LAB LTD-ADR | -- | $45,961.52 | 1,801 | BD9GVY0 |
| 0.07% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $45,916.00 | 4,415 | BRJZSK0 |
| 0.07% | ARDX | ARDELYX INC | -- | $45,460.74 | 9,074 | BN89V40 |
| 0.07% | CVAC | CUREVAC NV | -- | $45,447.44 | 8,479 | BN4RD42 |
| 0.07% | PGEN | PRECIGEN INC | -- | $45,441.00 | 11,220 | BKM5C84 |
| 0.07% | GMAB | GENMAB A/S -SP ADR | -- | $45,241.26 | 1,578 | BBC9WC7 |
| 0.06% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $43,423.77 | 3,243 | BN7Q7R7 |
| 0.06% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $43,155.00 | 1,750 | BNFWZS4 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $42,866.46 | 546 | BNSP8K3 |
| 0.06% | INVA | INNOVIVA INC | -- | $42,595.35 | 2,373 | BDDXF67 |
| 0.06% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $42,280.90 | 1,186 | BX7RSN3 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $42,071.88 | 4,593 | B8K7T65 |
| 0.06% | ORKA | ORUKA THERAPEUTICS INC | -- | $39,663.21 | 1,411 | BKVF0J2 |
| 0.06% | ANAB | ANAPTYSBIO INC | -- | $38,439.38 | 1,054 | BDRW1L7 |
| 0.06% | MNMD | MIND MEDICINE MINDMED INC | -- | $38,362.35 | 2,865 | BPQYY97 |
| 0.06% | XNCR | XENCOR INC | -- | $37,939.05 | 2,685 | BGCYWN8 |
| 0.05% | RAPP | RAPPORT THERAPEUTICS INC | -- | $36,933.12 | 1,374 | BR3T9B6 |
| 0.05% | NRIX | NURIX THERAPEUTICS INC | -- | $36,793.62 | 2,879 | BMVLGP2 |
| 0.05% | PCRX | PACIRA BIOSCIENCES INC | -- | $35,988.84 | 1,692 | B3X26D8 |
| 0.05% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $35,551.01 | 2,671 | BJLKVS6 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $34,939.96 | 7,219 | BZ0QMB7 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $34,578.70 | 1,742 | BZ7PJQ1 |
| 0.05% | FTRE | FORTREA HOLDINGS INC | -- | $34,252.45 | 3,415 | BRXYZ57 |
| 0.05% | KURA | KURA ONCOLOGY INC | -- | $34,128.36 | 3,269 | BYZD465 |
| 0.05% | TNGX | TANGO THERAPEUTICS INC | -- | $33,386.33 | 4,189 | BP2P6L0 |
| 0.05% | LENZ | LENZ THERAPEUTICS INC | -- | $32,714.04 | 1,074 | BQV0J03 |
| 0.05% | CRMD | CORMEDIX INC | -- | $32,663.82 | 2,811 | BJ0LT31 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $32,106.62 | 767 | BL95N25 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $32,075.02 | 3,721 | BMCR7V2 |
| 0.05% | PSNL | PERSONALIS INC | -- | $31,753.89 | 3,339 | BJQ0608 |
| 0.05% | EYPT | EYEPOINT PHARMACEUTICALS INC | -- | $31,684.95 | 2,595 | BMGS7L1 |
| 0.05% | TYRA | TYRA BIOSCIENCES INC | -- | $31,454.08 | 2,006 | BMVNDH9 |
| 0.05% | VIR | VIR BIOTECHNOLOGY INC | -- | $31,019.83 | 5,231 | BK4PZ38 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $30,342.96 | 4,556 | BYVQJ96 |
| 0.04% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $30,261.26 | 2,326 | BP7KZP7 |
| 0.04% | REPL | REPLIMUNE GROUP INC | -- | $30,124.75 | 2,939 | BDDVW37 |
| 0.04% | GERN | GERON CORP | -- | $29,788.52 | 24,023 | 2370381 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $29,212.54 | 1,778 | BQS7491 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $28,644.75 | 6,585 | BPBJFM7 |
| 0.04% | AVBP | ARRIVENT BIOPHARMA INC | -- | $28,203.69 | 1,527 | BMGTLY5 |
| 0.04% | SVRA | SAVARA INC | -- | $27,984.40 | 6,508 | BYXGN81 |
| 0.04% | ARVN | ARVINAS INC | -- | $27,446.52 | 2,764 | BDZ30Q0 |
| 0.04% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $27,160.32 | 3,858 | BLB0YH0 |
| 0.04% | TBPH | THERAVANCE BIOPHARMA INC | -- | $27,112.80 | 1,896 | BMNDK09 |
| 0.04% | TERN | TERNS PHARMACEUTICALS INC | -- | $26,887.20 | 3,295 | BMDJ0C9 |
| 0.04% | ATXS | ASTRIA THERAPEUTICS INC | -- | $26,583.75 | 2,125 | BMYRFN8 |
| 0.04% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $26,570.70 | 13,626 | BF0DMK7 |
| 0.04% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $26,443.17 | 3,029 | BFYQFJ2 |
| 0.04% | CSTL | CASTLE BIOSCIENCES INC | -- | $26,437.32 | 1,092 | BKLCWZ3 |
| 0.04% | ERAS | ERASCA INC | -- | $26,277.72 | 10,682 | BNLYBF3 |
| 0.04% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $25,969.02 | 3,234 | BYTYP72 |
| 0.04% | RGNX | REGENXBIO INC | -- | $24,383.64 | 1,902 | BZ0G875 |
| 0.03% | ABSI | ABSCI CORP | -- | $23,030.79 | 5,631 | BN94K69 |
| 0.03% | KROS | KEROS THERAPEUTICS INC | -- | $22,980.87 | 1,529 | BM7V485 |
| 0.03% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $22,687.52 | 2,584 | BMZ4LN0 |
| 0.03% | SIGA | SIGA TECHNOLOGIES INC | -- | $22,420.38 | 2,698 | 2107437 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $21,941.40 | 11,310 | B4N8MH9 |
| 0.03% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $21,774.56 | 2,806 | BYP80F1 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $21,753.90 | 3,453 | BMC3HS7 |
| 0.03% | ESPR | ESPERION THERAPEUTICS INC | -- | $21,561.28 | 7,592 | BBNBTD2 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $21,435.96 | 2,114 | BLFBZ32 |
| 0.03% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $21,375.12 | 676 | BQD3J33 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $21,242.96 | 2,027 | B91XRN2 |
| 0.03% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $20,799.12 | 1,896 | BD06CS0 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $19,911.88 | 1,759 | BKLXFX5 |
| 0.03% | OMER | OMEROS CORP | -- | $19,273.76 | 2,563 | B4NB858 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $19,171.19 | 2,033 | BQ6C357 |
| 0.03% | LXRX | LEXICON PHARMACEUTICALS INC | -- | $18,335.22 | 13,683 | BWFZX59 |
| 0.03% | NMRA | NEUMORA THERAPEUTICS INC | -- | $17,870.07 | 6,099 | BN4JN37 |
| 0.03% | NGNE | NEUROGENE INC | -- | $17,796.18 | 537 | BS2F741 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $17,109.86 | 5,449 | BMCWKZ2 |
| 0.03% | ALMS | ALUMIS INC | -- | $16,999.68 | 3,648 | BPLQG36 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $16,892.26 | 539 | B292NQ7 |
| 0.02% | HCM | HUTCHMED CHINA-ADR | -- | $16,854.24 | 1,168 | BYXV9H7 |
| 0.02% | CGEM | CULLINAN THERAPEUTICS INC | -- | $16,821.00 | 2,225 | BM90J52 |
| 0.02% | EOLS | EVOLUS INC | -- | $16,369.92 | 2,436 | BDRJH21 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $15,568.92 | 2,932 | BQHN6C7 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $15,251.16 | 1,741 | BKDQKM6 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $15,036.80 | 4,064 | BDFKQ07 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $14,227.20 | 2,340 | BP81R42 |
| 0.02% | DSGN | DESIGN THERAPEUTICS INC | -- | $14,006.85 | 2,145 | BMFK3H6 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $13,528.68 | 3,324 | BFY7DC4 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $13,020.92 | 3,223 | BMXNGZ6 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $12,924.08 | 1,768 | BL5B6Z1 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $12,779.78 | 3,781 | BZC0D70 |
| 0.02% | AMRN | AMARIN CORP PLC -ADR | -- | $12,447.60 | 759 | BN72KB0 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $12,390.40 | 704 | BPBPCG8 |
| 0.02% | ANNX | ANNEXON INC | -- | $12,127.27 | 4,139 | BMVV9R5 |
| 0.02% | LYEL | LYELL IMMUNOPHARMA INC | -- | $11,967.72 | 724 | BTNMG41 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $11,403.52 | 7,552 | BFMLGR4 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $10,995.75 | 1,629 | BSMLR16 |
| 0.02% | TKNO | ALPHA TEKNOVA INC | -- | $10,195.90 | 2,015 | BP7L561 |
| 0.02% | EDIT | EDITAS MEDICINE INC | -- | $10,191.86 | 3,386 | BZ8FPH3 |
| 0.01% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $10,109.55 | 8,355 | BFZNYB7 |
| 0.01% | TRDA | ENTRADA THERAPEUTICS INC | -- | $9,887.70 | 1,433 | BP81RK8 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $9,851.49 | 1,023 | BKC9SX3 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $9,770.76 | 2,988 | BLN9Z50 |
| 0.01% | HUMA | HUMACYTE INC | -- | $9,661.68 | 5,964 | BMYTJP4 |
| 0.01% | VNDA | VANDA PHARMACEUTICALS INC | -- | $9,612.00 | 2,225 | B12W3P6 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $9,442.28 | 2,089 | BY7RB53 |
| 0.01% | FHTX | FOGHORN THERAPEUTICS INC | -- | $9,175.99 | 2,129 | BMF7DT9 |
| 0.01% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $9,175.50 | 6,117 | B3MZ6K5 |
| 0.01% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $8,742.30 | 805 | B9L5200 |
| 0.01% | CDXS | CODEXIS INC | -- | $8,021.64 | 3,399 | B5LL2C2 |
| 0.01% | PYXS | PYXIS ONCOLOGY INC | -- | $7,989.12 | 2,336 | BLBR8D5 |
| 0.01% | RNAC | CARTESIAN THERAPEUTICS INC | -- | $7,939.69 | 979 | BQB9HM8 |
| 0.01% | OABI | OMNIAB INC | -- | $6,885.29 | 4,621 | BN13S71 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $6,595.26 | 2,681 | BKX9NQ0 |
| 0.01% | APLT | APPLIED THERAPEUTICS INC | -- | $6,127.99 | 5,423 | BJL38Z1 |
| 0.01% | MXCT | MAXCYTE INC | -- | $6,062.65 | 4,015 | BKMQF66 |
| 0.01% | ALEC | ALECTOR INC | -- | $5,794.24 | 3,812 | BJ4LDC4 |
| 0.01% | FATE | FATE THERAPEUTICS INC | -- | $5,602.47 | 4,343 | BCZS820 |
| 0.01% | PEPG | PEPGEN INC | -- | $5,594.55 | 1,235 | BMTX3D7 |
| 0.01% | NKTX | NKARTA INC | -- | $5,564.00 | 2,675 | BK80YJ8 |
| 0.01% | CLYM | CLIMB BIO INC | -- | $5,078.48 | 2,552 | BMW5LX6 |
| 0.01% | TVGN | TEVOGEN BIO HOLDINGS INC | -- | $4,447.90 | 7,407 | BPG5P75 |
| 0.01% | MGNX | MACROGENICS INC | -- | $3,797.70 | 2,381 | BFDV8K0 |
| 0.01% | PLRX | PLIANT THERAPEUTICS INC | -- | $3,791.68 | 2,312 | BMDWW66 |
| 0.01% | STRO | SUTRO BIOPHARMA INC | -- | $3,705.04 | 3,194 | BF12XC2 |
| 0.01% | TCRX | TSCAN THERAPEUTICS INC | -- | $3,677.22 | 1,977 | BNLYBJ7 |
| 0.01% | ARTV | ARTIVA BIOTHERAPEUTICS INC | -- | $3,624.80 | 920 | BMF1LJ7 |
| -- | BMEA | BIOMEA FUSION INC | -- | $2,981.86 | 2,242 | BNKF6N0 |
| -- | ACRV | ACRIVON THERAPEUTICS INC | -- | $2,298.90 | 1,185 | BP2TPK4 |
| -- | MRSN | MERSANA THERAPEUTICS INC | -- | $1,757.70 | 189 | BVPKH99 |
| -- | OKUR | ONKURE THERAPEUTICS INC-A | -- | $1,621.40 | 484 | BT7KGT6 |
| -- | QTTB | Q32 BIO INC | -- | $1,272.36 | 461 | BS2FKQ4 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 39.59% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 26,821,967 | -- | 5,058 | -- |
| 29.86% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 20,225,184 | -- | 3,814 | -- |
| 19.89% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 13,474,618 | -- | 2,541 | -- |
| 19.44% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 13,172,354 | -- | 2,484 | -- |
| 18.00% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 12,191,321 | -- | 2,299 | -- |
| 9.04% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 6,124,826 | -- | 1,155 | -- |
| -- | -- | TREASURY BILL | -- | $4,989,245.85 | 5,000,000 | BMGHP58 |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $19,153,886.36 | 19,153,886 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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