BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 2/28/2026
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 6.03% | 5.70% | 60.37% | 10.56% | 62.26% | 19.25% | -0.31% | 8.72% | 16.98% | 04/07/2010 |
| BIB Market Price | 6.05% | 5.51% | 60.28% | 10.49% | 62.05% | 19.26% | -0.28% | 8.72% | 16.98% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Net Assets $76,721,553
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 3/23/2026- NAV $75.96
- NAV Change $+0.82
- Market Price $75.95
- Market Price Change $+0.87
- Trading Volume (M) 19,723
- 30-Day Median Bid Ask Spread 0.24%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Net Assets $76,721,553
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 3/23/2026- NAV $75.96
- NAV Change $+0.82
- Market Price $75.95
- Market Price Change $+0.87
- Trading Volume (M) 19,723
- 30-Day Median Bid Ask Spread 0.24%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 12/31/2025
Holdings
as of 3/23/2026
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.69% | GILD | GILEAD SCIENCES INC | -- | $4,364,253.18 | 31,777 | 2369174 |
| 5.60% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $4,298,915.85 | 9,527 | 2931034 |
| 5.56% | AMGN | AMGEN INC | -- | $4,265,095.38 | 12,194 | 2023607 |
| 4.59% | REGN | REGENERON PHARMACEUTICALS | -- | $3,519,876.87 | 4,779 | 2730190 |
| 2.44% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $1,870,626.00 | 6,100 | B00FWN1 |
| 1.86% | INSM | INSMED INC | -- | $1,427,417.72 | 9,914 | 2614487 |
| 1.62% | BIIB | BIOGEN INC | -- | $1,239,570.00 | 6,750 | 2455965 |
| 1.37% | UTHR | UNITED THERAPEUTICS CORP | -- | $1,050,779.52 | 2,016 | 2430412 |
| 1.21% | MRNA | MODERNA INC | -- | $931,501.20 | 18,165 | BGSXTS3 |
| 1.20% | ROIV | ROIVANT SCIENCES LTD | -- | $919,427.67 | 32,919 | BMW4NZ9 |
| 1.17% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $898,745.05 | 19,705 | BMVP7Y0 |
| 1.16% | ARGX | ARGENX SE - ADR | -- | $889,814.25 | 1,305 | BDVLM39 |
| 1.15% | RVMD | REVOLUTION MEDICINES INC | -- | $880,782.45 | 9,115 | BL71K91 |
| 1.13% | ILMN | ILLUMINA INC | -- | $870,615.07 | 7,033 | 2613990 |
| 1.08% | INCY | INCYTE CORP | -- | $827,979.30 | 9,154 | 2471950 |
| 0.92% | VTRS | VIATRIS INC | -- | $703,825.11 | 52,959 | BMWS3X9 |
| 0.81% | BBIO | BRIDGEBIO PHARMA INC | -- | $620,623.20 | 8,917 | BK1KWG8 |
| 0.80% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $617,545.92 | 2,832 | BV9G6B8 |
| 0.78% | MEDP | MEDPACE HOLDINGS INC | -- | $596,293.65 | 1,305 | BDCBC61 |
| 0.76% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $586,462.80 | 4,616 | 2623911 |
| 0.73% | SMMT | SUMMIT THERAPEUTICS INC | -- | $556,358.40 | 35,664 | BMTVQS7 |
| 0.70% | IONS | IONIS PHARMACEUTICALS INC | -- | $537,862.42 | 7,598 | BDJ0LS6 |
| 0.67% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $516,330.24 | 2,832 | B4Q5ZN4 |
| 0.67% | GH | GUARDANT HEALTH INC | -- | $512,563.68 | 6,033 | BFXC911 |
| 0.66% | SNY | SANOFI-ADR | -- | $503,975.89 | 11,257 | 2964557 |
| 0.64% | EXEL | EXELIXIS INC | -- | $494,642.45 | 11,945 | 2576941 |
| 0.63% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $484,583.88 | 8,846 | 2437071 |
| 0.62% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $472,344.60 | 1,055 | BD59BS7 |
| 0.60% | BNTX | BIONTECH SE-ADR | -- | $463,268.40 | 5,240 | BK6H543 |
| 0.58% | IBRX | IMMUNITYBIO INC | -- | $444,516.60 | 47,289 | BNSP0B8 |
| 0.53% | ONC | BEONE MEDICINES LTD-ADR | -- | $403,853.10 | 1,470 | BYYWPW6 |
| 0.51% | TEM | TEMPUS AI INC-CL A | -- | $392,677.74 | 7,991 | BSLSJJ0 |
| 0.49% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $376,754.91 | 1,281 | BQ721R4 |
| 0.48% | PCVX | VAXCYTE INC | -- | $370,322.80 | 6,620 | BKPVGH6 |
| 0.48% | AXSM | AXSOME THERAPEUTICS INC | -- | $369,044.52 | 2,353 | BYZR4X4 |
| 0.48% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $365,011.47 | 6,441 | BYQBFJ8 |
| 0.45% | CYTK | CYTOKINETICS INC | -- | $345,281.75 | 5,665 | BBBSBJ5 |
| 0.44% | HALO | HALOZYME THERAPEUTICS INC | -- | $341,204.08 | 5,428 | 2975098 |
| 0.44% | KRYS | KRYSTAL BIOTECH INC | -- | $336,357.60 | 1,345 | BD6JX35 |
| 0.43% | ABVX | ABIVAX SA-ADR | -- | $326,176.92 | 2,826 | BLC89B2 |
| 0.42% | NUVL | NUVALENT INC-A | -- | $324,583.38 | 3,366 | BMVBZD3 |
| 0.40% | ACLX | ARCELLX INC | -- | $308,274.00 | 2,690 | BPCJ1Q2 |
| 0.38% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $289,214.90 | 2,935 | BDCBCD8 |
| 0.38% | KYMR | KYMERA THERAPEUTICS INC | -- | $288,984.80 | 3,755 | BMPRZV5 |
| 0.35% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $265,885.65 | 3,141 | BF2YWG4 |
| 0.34% | COGT | COGENT BIOSCIENCES INC | -- | $264,335.65 | 7,465 | BLR6XK8 |
| 0.33% | PTCT | PTC THERAPEUTICS INC | -- | $252,860.94 | 3,807 | B17VCN9 |
| 0.33% | CGON | CG ONCOLOGY INC | -- | $252,304.64 | 3,884 | BRBCSP4 |
| 0.33% | CAI | CARIS LIFE SCIENCES INC | -- | $249,956.28 | 12,978 | BT18HP9 |
| 0.32% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $248,168.25 | 2,775 | BJDX8Y8 |
| 0.32% | TERN | TERNS PHARMACEUTICALS INC | -- | $242,642.51 | 4,891 | BMDJ0C9 |
| 0.30% | IMVT | IMMUNOVANT INC | -- | $228,245.56 | 9,362 | BJRFSB7 |
| 0.28% | ALKS | ALKERMES PLC | -- | $212,397.15 | 7,665 | B3P6D26 |
| 0.27% | XENE | XENON PHARMACEUTICALS INC | -- | $208,210.92 | 3,826 | BRJ3GY4 |
| 0.27% | CRSP | CRISPR THERAPEUTICS AG | -- | $206,975.20 | 4,415 | BDHF4K6 |
| 0.27% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $204,852.72 | 4,692 | BFZQ0L8 |
| 0.27% | ERAS | ERASCA INC | -- | $203,916.80 | 14,240 | BNLYBF3 |
| 0.26% | APGE | APOGEE THERAPEUTICS INC | -- | $199,843.28 | 2,522 | BM9HHL5 |
| 0.24% | LGND | LIGAND PHARMACEUTICALS | -- | $183,730.12 | 917 | 2501578 |
| 0.23% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $175,781.98 | 3,583 | BQS9486 |
| 0.22% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $172,506.24 | 14,472 | BFNF1D6 |
| 0.22% | INDV | INDIVIOR PHARMACEUTICALS INC | -- | $169,051.28 | 5,752 | BTZRLN8 |
| 0.22% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $167,163.36 | 4,816 | BDD19F8 |
| 0.21% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $164,603.58 | 7,842 | 2713317 |
| 0.21% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $158,692.88 | 5,288 | BP8JSP4 |
| 0.20% | SYRE | SPYRE THERAPEUTICS INC | -- | $154,491.88 | 3,613 | BQBBDY8 |
| 0.20% | DNLI | DENALI THERAPEUTICS INC | -- | $153,851.55 | 7,295 | BD2B4V0 |
| 0.19% | ADMA | ADMA BIOLOGICS INC | -- | $148,864.86 | 10,954 | B9NSBM2 |
| 0.19% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $147,033.20 | 4,934 | BKY5JZ8 |
| 0.19% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $142,695.94 | 5,501 | BLB0YQ9 |
| 0.18% | ALMS | ALUMIS INC | -- | $135,838.40 | 5,815 | BPLQG36 |
| 0.18% | DYN | DYNE THERAPEUTICS INC | -- | $135,329.51 | 7,573 | BN15WD1 |
| 0.17% | VERA | VERA THERAPEUTICS INC | -- | $133,675.86 | 3,282 | BL55460 |
| 0.17% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $129,872.25 | 2,637 | B72ZBG4 |
| 0.17% | IDYA | IDEAYA BIOSCIENCES INC | -- | $127,793.96 | 4,039 | BK0VHF6 |
| 0.17% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $127,053.00 | 5,700 | BKX9VD3 |
| 0.16% | TARS | TARSUS PHARMACEUTICALS INC | -- | $125,502.41 | 1,957 | BMH5RL1 |
| 0.16% | TWST | TWIST BIOSCIENCE CORP | -- | $125,490.00 | 2,820 | BGKG6G7 |
| 0.16% | VCYT | VERACYTE INC | -- | $122,588.70 | 3,655 | BFTWZY0 |
| 0.15% | BEAM | BEAM THERAPEUTICS INC | -- | $117,921.45 | 4,685 | BK6L288 |
| 0.15% | TVTX | TRAVERE THERAPEUTICS INC | -- | $117,743.25 | 4,243 | BLFGJD5 |
| 0.15% | TNGX | TANGO THERAPEUTICS INC | -- | $117,457.20 | 6,195 | BP2P6L0 |
| 0.15% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $113,052.80 | 11,536 | 2100362 |
| 0.14% | MAZE | MAZE THERAPEUTICS INC | -- | $108,437.00 | 2,213 | BSRK699 |
| 0.14% | IRON | DISC MEDICINE INC | -- | $103,738.05 | 1,755 | BMGJZJ8 |
| 0.14% | TXG | 10X GENOMICS INC-CLASS A | -- | $103,585.68 | 5,412 | BKS3RS7 |
| 0.13% | APLS | APELLIS PHARMACEUTICALS INC | -- | $103,311.60 | 5,880 | BYTQ6X1 |
| 0.13% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $101,481.36 | 4,751 | BLB0YH0 |
| 0.13% | WVE | WAVE LIFE SCIENCES LTD | -- | $100,617.58 | 8,659 | BYZG9R0 |
| 0.13% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $97,733.13 | 4,057 | BN7Q7R7 |
| 0.13% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $97,190.44 | 2,111 | BRXB0C0 |
| 0.13% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $96,740.12 | 7,082 | BJ5FZ74 |
| 0.12% | ORKA | ORUKA THERAPEUTICS INC | -- | $92,554.12 | 2,227 | BKVF0J2 |
| 0.12% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $90,100.15 | 4,445 | BJ62Z18 |
| 0.12% | TYRA | TYRA BIOSCIENCES INC | -- | $89,656.60 | 2,455 | BMVNDH9 |
| 0.12% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $89,048.96 | 6,116 | BFWLC09 |
| 0.11% | GRAL | GRAIL INC | -- | $88,090.09 | 1,793 | BSLSSX7 |
| 0.11% | STOK | STOKE THERAPEUTICS INC | -- | $87,741.80 | 2,627 | BJQ05Z6 |
| 0.11% | MLYS | MINERALYS THERAPEUTICS INC | -- | $86,086.00 | 3,640 | BP9N0G0 |
| 0.11% | SRPT | SAREPTA THERAPEUTICS INC | -- | $85,362.20 | 4,820 | B8DPDT7 |
| 0.11% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $84,111.30 | 2,730 | BMFD115 |
| 0.11% | DFTX | DEFINIUM THERAPEUTICS INC | -- | $83,006.60 | 4,586 | BV2DHY6 |
| 0.11% | ZYME | ZYMEWORKS INC | -- | $82,676.84 | 3,442 | BPCQZY9 |
| 0.11% | OCUL | OCULAR THERAPEUTIX INC | -- | $81,105.30 | 10,013 | BNZB1X8 |
| 0.11% | RLAY | RELAY THERAPEUTICS INC | -- | $80,730.22 | 8,221 | BN2R582 |
| 0.10% | ANAB | ANAPTYSBIO INC | -- | $79,905.28 | 1,274 | BDRW1L7 |
| 0.10% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $77,542.61 | 24,007 | BM9FJ13 |
| 0.10% | ANIP | ANI PHARMACEUTICALS INC | -- | $76,211.52 | 1,031 | BCDWBX6 |
| 0.10% | GMAB | GENMAB A/S -SP ADR | -- | $76,038.48 | 2,961 | BBC9WC7 |
| 0.10% | VCEL | VERICEL CORP | -- | $75,770.75 | 2,335 | BSBMN89 |
| 0.10% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $75,756.45 | 2,695 | BCBVTX1 |
| 0.10% | PHVS | PHARVARIS NV | -- | $75,712.20 | 2,946 | BMZ2X38 |
| 0.10% | SION | SIONNA THERAPEUTICS INC | -- | $74,790.79 | 2,053 | BQKXDX4 |
| 0.10% | INVA | INNOVIVA INC | -- | $74,647.37 | 3,407 | BDDXF67 |
| 0.10% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $73,416.00 | 2,660 | BKSGZN7 |
| 0.09% | NVAX | NOVAVAX INC | -- | $72,841.68 | 7,494 | BJDQXG4 |
| 0.09% | NTLA | INTELLIA THERAPEUTICS INC | -- | $71,239.74 | 5,434 | BYZM6C2 |
| 0.09% | NRIX | NURIX THERAPEUTICS INC | -- | $69,483.70 | 4,730 | BMVLGP2 |
| 0.09% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $68,781.24 | 18,948 | BF0DMK7 |
| 0.09% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $68,340.03 | 5,051 | BPCK358 |
| 0.09% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $66,886.86 | 3,882 | BMX9K07 |
| 0.08% | VIR | VIR BIOTECHNOLOGY INC | -- | $63,904.36 | 7,229 | BK4PZ38 |
| 0.08% | TRVI | TREVI THERAPEUTICS INC | -- | $63,462.48 | 5,898 | BJH9ZN0 |
| 0.08% | KOD | KODIAK SCIENCES INC | -- | $62,449.92 | 2,808 | BFXC933 |
| 0.08% | NVCR | NOVOCURE LTD | -- | $61,865.88 | 5,234 | BYSS4X4 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $61,215.95 | 2,017 | BLCD809 |
| 0.08% | RAPP | RAPPORT THERAPEUTICS INC | -- | $61,178.72 | 2,192 | BR3T9B6 |
| 0.08% | ARDX | ARDELYX INC | -- | $59,896.80 | 11,280 | BN89V40 |
| 0.08% | MBX | MBX BIOSCIENCES INC | -- | $58,109.10 | 2,065 | BQXJKH2 |
| 0.08% | HROW | HARROW INC | -- | $57,936.00 | 1,704 | BHNDW86 |
| 0.07% | TSHA | TAYSHA GENE THERAPIES INC | -- | $57,199.46 | 12,599 | BNC1BX1 |
| 0.07% | ATAI | ATAIBECKLEY INC | -- | $56,633.34 | 16,706 | BWJDYK1 |
| 0.07% | BCAX | BICARA THERAPEUTICS INC | -- | $53,588.46 | 2,914 | BQB42F1 |
| 0.07% | PGEN | PRECIGEN INC | -- | $52,727.76 | 16,274 | BKM5C84 |
| 0.07% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $52,710.21 | 3,507 | BP7KZP7 |
| 0.07% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $52,222.50 | 3,798 | BYP80F1 |
| 0.07% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $51,507.39 | 3,687 | BMZ4LN0 |
| 0.07% | ORIC | ORIC PHARMACEUTICALS INC | -- | $51,376.08 | 4,616 | BKVDFF7 |
| 0.07% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $51,056.20 | 949 | BL95N25 |
| 0.07% | ZBIO | ZENAS BIOPHARMA INC | -- | $50,935.47 | 2,469 | BQB42H3 |
| 0.07% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $50,747.84 | 1,461 | BX7RSN3 |
| 0.07% | ALVO | ALVOTECH SA | -- | $50,589.36 | 15,192 | BPNTJ34 |
| 0.06% | SEPN | SEPTERNA INC | -- | $48,963.02 | 2,059 | BQNKXX2 |
| 0.06% | EYPT | EYEPOINT INC | -- | $48,856.64 | 3,808 | BMGS7L1 |
| 0.06% | SVRA | SAVARA INC | -- | $47,543.72 | 9,359 | BYXGN81 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $46,991.28 | 13,944 | BL53SR3 |
| 0.06% | QURE | UNIQURE NV | -- | $45,610.80 | 2,865 | BJFSR88 |
| 0.06% | GERN | GERON CORP | -- | $45,217.48 | 29,362 | 2370381 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $43,237.47 | 669 | BNSP8K3 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $43,148.59 | 5,611 | B8K7T65 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $42,815.52 | 7,632 | BLR7H87 |
| 0.05% | PCRX | PACIRA BIOSCIENCES INC | -- | $42,174.30 | 1,862 | B3X26D8 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $42,119.82 | 1,899 | BMGTLY5 |
| 0.05% | FTRE | FORTREA HOLDINGS INC | -- | $41,934.75 | 4,301 | BRXYZ57 |
| 0.05% | XNCR | XENCOR INC | -- | $40,644.65 | 3,373 | BGCYWN8 |
| 0.05% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $40,133.01 | 2,087 | BNFWZS4 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $39,099.32 | 8,846 | BZ0QMB7 |
| 0.05% | JANX | JANUX THERAPEUTICS INC | -- | $38,892.20 | 2,798 | BMFX8Y7 |
| 0.05% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $38,595.00 | 2,325 | BD06CS0 |
| 0.05% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $38,305.68 | 3,624 | BJLKVS6 |
| 0.05% | SANA | SANA BIOTECHNOLOGY INC | -- | $38,226.24 | 12,252 | BMFJJ97 |
| 0.05% | GHRS | GH RESEARCH PLC | -- | $37,688.13 | 2,853 | BP6C0S2 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $37,246.90 | 2,153 | BZ7PJQ1 |
| 0.05% | BIOA | BIOAGE LABS INC | -- | $37,222.74 | 1,998 | BT9K6D8 |
| 0.05% | PSNL | PERSONALIS INC | -- | $36,626.93 | 4,813 | BJQ0608 |
| 0.05% | ANNX | ANNEXON INC | -- | $35,748.09 | 6,657 | BMVV9R5 |
| 0.05% | CSTL | CASTLE BIOSCIENCES INC | -- | $35,226.00 | 1,368 | BKLCWZ3 |
| 0.05% | CGEM | CULLINAN THERAPEUTICS INC | -- | $34,886.28 | 2,717 | BM90J52 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $34,875.49 | 4,547 | BMCR7V2 |
| 0.05% | OMER | OMEROS CORP | -- | $34,762.26 | 3,261 | B4NB858 |
| 0.05% | CTMX | CYTOMX THERAPEUTICS INC | -- | $34,756.78 | 7,793 | BYWVTY5 |
| 0.05% | MNKD | MANNKIND CORP | -- | $34,577.24 | 14,171 | BF081J4 |
| 0.04% | TBPH | THERAVANCE BIOPHARMA INC | -- | $34,382.25 | 2,331 | BMNDK09 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $33,760.16 | 2,408 | BQS7491 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $33,296.64 | 4,002 | BYZD465 |
| 0.04% | ARVN | ARVINAS INC | -- | $30,361.44 | 2,942 | BDZ30Q0 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $29,724.74 | 8,303 | BPBJFM7 |
| 0.04% | ETON | ETON PHARMACEUTICALS INC | -- | $29,357.73 | 1,233 | BGL0JK3 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $28,809.52 | 10,996 | BBNBTD2 |
| 0.04% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $28,320.30 | 3,702 | BFYQFJ2 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $27,770.97 | 1,577 | BD9GVY0 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $26,645.40 | 2,620 | BMFK3H6 |
| 0.03% | REPL | REPLIMUNE GROUP INC | -- | $26,510.04 | 3,798 | BDDVW37 |
| 0.03% | SLDB | SOLID BIOSCIENCES INC | -- | $25,589.76 | 3,584 | BQHN6C7 |
| 0.03% | TECX | TECTONIC THERAPEUTIC INC | -- | $25,436.16 | 864 | BPBPCG8 |
| 0.03% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $25,222.28 | 10,337 | BFZNYB7 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $24,635.52 | 7,488 | B3MZ6K5 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $24,388.38 | 2,589 | BLFBZ32 |
| 0.03% | VOR | VOR BIOPHARMA INC | -- | $24,237.90 | 1,910 | BRJJYT3 |
| 0.03% | LRMR | LARIMAR THERAPEUTICS INC | -- | $23,376.60 | 4,995 | BMXNGZ6 |
| 0.03% | CRMD | CORMEDIX INC | -- | $23,266.08 | 3,624 | BJ0LT31 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $23,164.92 | 4,338 | BMC3HS7 |
| 0.03% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $22,127.50 | 835 | BQD3J33 |
| 0.03% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $22,055.16 | 5,612 | BYVQJ96 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $21,838.32 | 2,476 | B91XRN2 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $21,755.80 | 682 | B292NQ7 |
| 0.03% | KMDA | KAMADA LTD | -- | $21,754.60 | 2,653 | B2Q9833 |
| 0.03% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $21,673.96 | 4,994 | BDFKQ07 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $21,653.58 | 2,346 | BKLXFX5 |
| 0.03% | FULC | FULCRUM THERAPEUTICS INC | -- | $21,104.07 | 3,063 | BJDX8Z9 |
| 0.03% | UPB | UPSTREAM BIO INC | -- | $21,006.70 | 2,486 | BRCFFK6 |
| 0.03% | KYTX | KYVERNA THERAPEUTICS INC | -- | $20,734.92 | 2,628 | BSMLR16 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $20,670.31 | 6,733 | BMCWKZ2 |
| 0.03% | ABSI | ABSCI CORP | -- | $20,263.88 | 6,916 | BN94K69 |
| 0.03% | TRDA | ENTRADA THERAPEUTICS INC | -- | $20,233.89 | 1,761 | BP81RK8 |
| 0.03% | AVIR | ATEA PHARMACEUTICALS INC | -- | $20,013.01 | 3,593 | BLN9Z50 |
| 0.03% | ACRS | ACLARIS THERAPEUTICS INC | -- | $19,858.26 | 5,547 | BYV2W40 |
| 0.03% | ALT | ALTIMMUNE INC | -- | $19,814.40 | 5,760 | BFY7DC4 |
| 0.03% | RGNX | REGENXBIO INC | -- | $19,415.52 | 2,328 | BZ0G875 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $19,308.49 | 13,891 | B4N8MH9 |
| 0.02% | LYEL | LYELL IMMUNOPHARMA INC | -- | $19,100.35 | 977 | BTNMG41 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $19,096.00 | 2,728 | B12W3P6 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $19,074.13 | 2,921 | BP81R42 |
| 0.02% | IVVD | INVIVYD INC | -- | $18,991.54 | 12,746 | BM8NHS1 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $18,981.95 | 7,685 | BN4JN37 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $18,923.28 | 4,262 | BYTYP72 |
| 0.02% | LXEO | LEXEO THERAPEUTICS INC | -- | $18,597.78 | 3,357 | BQ6C357 |
| 0.02% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $17,388.00 | 1,400 | BPRBTY7 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $16,887.75 | 1,335 | B9L5200 |
| 0.02% | CADL | CANDEL THERAPEUTICS INC | -- | $16,776.38 | 3,362 | BP0TQC5 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $16,437.06 | 3,294 | 2107437 |
| 0.02% | LENZ | LENZ THERAPEUTICS INC | -- | $15,829.00 | 1,439 | BQV0J03 |
| 0.02% | KROS | KEROS THERAPEUTICS INC | -- | $15,747.24 | 1,401 | BM7V485 |
| 0.02% | PEPG | PEPGEN INC | -- | $15,114.36 | 3,162 | BMTX3D7 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $15,114.24 | 2,952 | BMVBZF5 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $14,625.00 | 2,340 | B7F2TY6 |
| 0.02% | EOLS | EVOLUS INC | -- | $13,951.08 | 2,981 | BDRJH21 |
| 0.02% | NGNE | NEUROGENE INC | -- | $13,784.32 | 712 | BS2F741 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $13,712.46 | 2,694 | BMF7DT9 |
| 0.02% | NBP | NOVABRIDGE BIOSCIENCES | -- | $13,578.69 | 5,163 | BKRRKY7 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $13,325.76 | 4,627 | BZC0D70 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $12,917.80 | 9,227 | BFMLGR4 |
| 0.02% | CABA | CABALETTA BIO INC | -- | $12,486.96 | 4,428 | BK5MWR1 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $12,474.00 | 2,160 | BL5B6Z1 |
| 0.02% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $12,361.72 | 2,597 | BPRB2N7 |
| 0.02% | OABI | OMNIAB INC | -- | $11,652.96 | 6,621 | BN13S71 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $11,489.28 | 4,488 | BKX9NQ0 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $11,275.00 | 6,875 | BRK0149 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $10,776.00 | 4,490 | BZ8FPH3 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $10,518.68 | 2,711 | BY7RB53 |
| 0.01% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $9,248.54 | 2,131 | BKDQKM6 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $8,979.09 | 1,307 | BKC9SX3 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $8,071.22 | 8,988 | BNR5QT9 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $7,996.14 | 4,299 | BNYJR68 |
| 0.01% | HUMA | HUMACYTE INC | -- | $7,548.11 | 8,877 | BMYTJP4 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $7,492.46 | 9,970 | BNNXX52 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $7,189.04 | 2,462 | BP7L561 |
| 0.01% | LFCR | LIFECORE BIOMEDICAL INC | -- | $6,978.15 | 1,723 | 2517058 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $6,958.88 | 1,426 | BP2NYN2 |
| 0.01% | CDXS | CODEXIS INC | -- | $6,689.55 | 4,155 | B5LL2C2 |
| 0.01% | MENS | JYONG BIOTECH LTD | -- | $6,657.30 | 3,414 | BPTK6Z2 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $5,635.15 | 2,621 | BKTV702 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $5,115.18 | 4,487 | BNNXX18 |
| 0.01% | AARD | AARDVARK THERAPEUTICS INC | -- | $4,069.07 | 1,001 | BTXQTX3 |
| 0.01% | PYXS | PYXIS ONCOLOGY INC | -- | $4,066.88 | 2,864 | BLBR8D5 |
| 0.01% | GOSS | GOSSAMER BIO INC | -- | $3,973.09 | 10,646 | BJ0CK86 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $21.33 | 01 | BTFHQP5 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| 31.46% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 24,134,689 | -- | 4,292 | -- |
| 31.39% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 24,084,080 | -- | 4,283 | -- |
| 27.13% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 20,817,012 | -- | 3,702 | -- |
| 19.34% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 14,839,572 | -- | 2,639 | -- |
| 14.59% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 11,190,128 | -- | 1,990 | -- |
| 4.64% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,559,473 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $21,628,274.89 | 21,628,275 | -- |
Index
as of 12/31/2025
- Total Number of Companies262
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$7.32 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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