BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 12/31/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 1/13/2026- NAV $81.37
- NAV Change $+0.01
- Market Price $81.35
- Market Price Change $-0.01
- Trading Volume (M) 6,097
- 30-Day Median Bid Ask Spread 0.26%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 1/13/2026- NAV $81.37
- NAV Change $+0.01
- Market Price $81.35
- Market Price Change $-0.01
- Trading Volume (M) 6,097
- 30-Day Median Bid Ask Spread 0.26%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 12/31/2025
Holdings
as of 1/13/2026
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.92% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,107,308.11 | 11,233 | 2931034 |
| 5.46% | GILD | GILEAD SCIENCES INC | -- | $4,711,137.92 | 38,692 | 2369174 |
| 5.30% | AMGN | AMGEN INC | -- | $4,571,332.80 | 14,096 | 2023607 |
| 4.07% | REGN | REGENERON PHARMACEUTICALS | -- | $3,509,199.84 | 4,624 | 2730190 |
| 2.86% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $2,470,585.91 | 26,141 | 2989044 |
| 2.54% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,188,313.40 | 5,915 | B00FWN1 |
| 1.81% | INSM | INSMED INC | -- | $1,563,362.28 | 9,549 | 2614487 |
| 1.36% | BIIB | BIOGEN INC | -- | $1,171,252.70 | 6,569 | 2455965 |
| 1.23% | ARGX | ARGENX SE - ADR | -- | $1,056,905.04 | 1,304 | BDVLM39 |
| 1.20% | RVMD | REVOLUTION MEDICINES INC | -- | $1,038,287.20 | 8,656 | BL71K91 |
| 1.17% | ILMN | ILLUMINA INC | -- | $1,005,558.59 | 6,841 | 2613990 |
| 1.07% | UTHR | UNITED THERAPEUTICS CORP | -- | $919,386.08 | 1,928 | 2430412 |
| 1.05% | INCY | INCYTE CORP | -- | $909,149.70 | 8,790 | 2471950 |
| 0.90% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $772,046.44 | 19,129 | BMVP7Y0 |
| 0.89% | MEDP | MEDPACE HOLDINGS INC | -- | $767,230.23 | 1,261 | BDCBC61 |
| 0.85% | ROIV | ROIVANT SCIENCES LTD | -- | $729,898.16 | 31,139 | BMW4NZ9 |
| 0.80% | MRNA | MODERNA INC | -- | $692,485.20 | 17,487 | BGSXTS3 |
| 0.80% | VTRS | VIATRIS INC | -- | $689,196.76 | 51,548 | BMWS3X9 |
| 0.79% | BBIO | BRIDGEBIO PHARMA INC | -- | $682,561.08 | 8,628 | BK1KWG8 |
| 0.72% | GH | GUARDANT HEALTH INC | -- | $619,106.88 | 5,792 | BFXC911 |
| 0.69% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $591,172.45 | 2,749 | BV9G6B8 |
| 0.68% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $590,408.64 | 4,464 | 2623911 |
| 0.67% | IONS | IONIS PHARMACEUTICALS INC | -- | $576,388.96 | 7,252 | BDJ0LS6 |
| 0.65% | SMMT | SUMMIT THERAPEUTICS INC | -- | $560,294.11 | 33,331 | BMTVQS7 |
| 0.65% | SNY | SANOFI-ADR | -- | $559,225.60 | 11,848 | 2964557 |
| 0.61% | EXEL | EXELIXIS INC | -- | $529,136.32 | 12,004 | 2576941 |
| 0.60% | TEM | TEMPUS AI INC | -- | $519,673.85 | 7,739 | BSLSJJ0 |
| 0.58% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $502,296.30 | 1,017 | BD59BS7 |
| 0.57% | ONC | BEONE MEDICINES LTD-ADR | -- | $494,643.54 | 1,409 | BYYWPW6 |
| 0.57% | RNA | AVIDITY BIOSCIENCES INC | -- | $488,612.78 | 6,746 | BMWHPY1 |
| 0.56% | BNTX | BIONTECH SE-ADR | -- | $485,034.75 | 4,525 | BK6H543 |
| 0.55% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $474,333.60 | 8,593 | 2437071 |
| 0.51% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $441,972.03 | 2,721 | B4Q5ZN4 |
| 0.46% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $398,579.15 | 6,081 | BYQBFJ8 |
| 0.46% | AXSM | AXSOME THERAPEUTICS INC | -- | $393,462.81 | 2,257 | BYZR4X4 |
| 0.44% | KRYS | KRYSTAL BIOTECH INC | -- | $379,217.07 | 1,299 | BD6JX35 |
| 0.44% | HALO | HALOZYME THERAPEUTICS INC | -- | $377,342.55 | 5,265 | 2975098 |
| 0.42% | CYTK | CYTOKINETICS INC | -- | $366,490.71 | 5,787 | BBBSBJ5 |
| 0.39% | CAI | CARIS LIFE SCIENCES INC | -- | $333,484.80 | 12,632 | BT18HP9 |
| 0.38% | NUVL | NUVALENT INC-A | -- | $327,183.78 | 3,234 | BMVBZD3 |
| 0.37% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $322,106.40 | 2,988 | BF2YWG4 |
| 0.37% | ABVX | ABIVAX SA-ADR | -- | $316,208.52 | 2,643 | BLC89B2 |
| 0.36% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $314,529.60 | 1,120 | BQ721R4 |
| 0.31% | PTCT | PTC THERAPEUTICS INC | -- | $270,987.60 | 3,594 | B17VCN9 |
| 0.31% | PCVX | VAXCYTE INC | -- | $269,907.30 | 5,865 | BKPVGH6 |
| 0.28% | COGT | COGENT BIOSCIENCES INC | -- | $242,373.60 | 6,870 | BLR6XK8 |
| 0.28% | CRSP | CRISPR THERAPEUTICS AG | -- | $239,270.62 | 4,259 | BDHF4K6 |
| 0.28% | KYMR | KYMERA THERAPEUTICS INC | -- | $238,772.73 | 3,221 | BMPRZV5 |
| 0.27% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $233,526.24 | 2,997 | BQS9486 |
| 0.27% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $230,708.88 | 4,248 | BDD19F8 |
| 0.26% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $227,726.64 | 2,799 | BDCBCD8 |
| 0.25% | ALKS | ALKERMES PLC | -- | $215,593.40 | 7,396 | B3P6D26 |
| 0.24% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $208,102.44 | 2,301 | BJDX8Y8 |
| 0.24% | IMVT | IMMUNOVANT INC | -- | $205,408.28 | 7,846 | BJRFSB7 |
| 0.23% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $200,434.50 | 7,575 | 2713317 |
| 0.23% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $199,850.00 | 4,568 | BFZQ0L8 |
| 0.23% | FOLD | AMICUS THERAPEUTICS INC | -- | $197,816.48 | 13,814 | B19FQ48 |
| 0.22% | APGE | APOGEE THERAPEUTICS INC | -- | $193,945.00 | 2,455 | BM9HHL5 |
| 0.22% | INDV | INDIVIOR PLC | -- | $190,060.00 | 5,590 | BP0BQQ5 |
| 0.22% | CGON | CG ONCOLOGY INC | -- | $189,708.64 | 3,608 | BRBCSP4 |
| 0.22% | ADMA | ADMA BIOLOGICS INC | -- | $188,611.20 | 10,656 | B9NSBM2 |
| 0.21% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $182,487.90 | 14,070 | BFNF1D6 |
| 0.21% | GRAL | GRAIL INC | -- | $178,039.62 | 1,746 | BSLSSX7 |
| 0.20% | ACLX | ARCELLX INC | -- | $172,815.75 | 2,589 | BPCJ1Q2 |
| 0.19% | LGND | LIGAND PHARMACEUTICALS | -- | $166,315.18 | 881 | 2501578 |
| 0.19% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $161,721.36 | 5,076 | BP8JSP4 |
| 0.18% | BEAM | BEAM THERAPEUTICS INC | -- | $156,960.65 | 4,543 | BK6L288 |
| 0.18% | VCYT | VERACYTE INC | -- | $152,612.25 | 3,545 | BFTWZY0 |
| 0.17% | TARS | TARSUS PHARMACEUTICALS INC | -- | $143,962.73 | 1,901 | BMH5RL1 |
| 0.17% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $142,858.20 | 5,484 | BKX9VD3 |
| 0.16% | VERA | VERA THERAPEUTICS INC | -- | $140,573.30 | 2,863 | BL55460 |
| 0.16% | XENE | XENON PHARMACEUTICALS INC | -- | $139,645.60 | 3,460 | BRJ3GY4 |
| 0.16% | TERN | TERNS PHARMACEUTICALS INC | -- | $138,936.85 | 4,033 | BMDJ0C9 |
| 0.16% | IDYA | IDEAYA BIOSCIENCES INC | -- | $137,728.25 | 3,925 | BK0VHF6 |
| 0.15% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $132,123.60 | 2,568 | B72ZBG4 |
| 0.15% | IRON | DISC MEDICINE INC | -- | $127,493.60 | 1,690 | BMGJZJ8 |
| 0.14% | IBRX | IMMUNITYBIO INC | -- | $124,362.00 | 44,100 | BNSP0B8 |
| 0.14% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $123,508.45 | 6,835 | BJ5FZ74 |
| 0.14% | APLS | APELLIS PHARMACEUTICALS INC | -- | $120,813.12 | 5,664 | BYTQ6X1 |
| 0.14% | DNLI | DENALI THERAPEUTICS INC | -- | $118,928.37 | 6,567 | BD2B4V0 |
| 0.14% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $118,263.00 | 4,740 | BKY5JZ8 |
| 0.14% | MLYS | MINERALYS THERAPEUTICS INC | -- | $116,739.36 | 3,544 | BP9N0G0 |
| 0.14% | TVTX | TRAVERE THERAPEUTICS INC | -- | $116,614.66 | 4,006 | BLFGJD5 |
| 0.13% | TWST | TWIST BIOSCIENCE CORP | -- | $110,041.92 | 2,736 | BGKG6G7 |
| 0.13% | SYRE | SPYRE THERAPEUTICS INC | -- | $109,535.22 | 3,474 | BQBBDY8 |
| 0.13% | DYN | DYNE THERAPEUTICS INC | -- | $108,953.76 | 6,394 | BN15WD1 |
| 0.13% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $107,973.18 | 23,022 | BM9FJ13 |
| 0.12% | TXG | 10X GENOMICS INC-CLASS A | -- | $107,032.32 | 5,216 | BKS3RS7 |
| 0.12% | WVE | WAVE LIFE SCIENCES LTD | -- | $106,436.70 | 7,485 | BYZG9R0 |
| 0.12% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $104,131.09 | 4,319 | BJ62Z18 |
| 0.12% | SRPT | SAREPTA THERAPEUTICS INC | -- | $100,432.80 | 4,680 | B8DPDT7 |
| 0.12% | OCUL | OCULAR THERAPEUTIX INC | -- | $99,450.05 | 9,535 | BNZB1X8 |
| 0.11% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $98,228.58 | 3,522 | BMZ4LN0 |
| 0.11% | ALMS | ALUMIS INC | -- | $96,244.83 | 4,353 | BPLQG36 |
| 0.11% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $95,968.18 | 4,319 | BLB0YQ9 |
| 0.11% | ERAS | ERASCA INC | -- | $95,328.51 | 12,702 | BNLYBF3 |
| 0.11% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $92,225.04 | 2,579 | BKSGZN7 |
| 0.10% | MAZE | MAZE THERAPEUTICS INC | -- | $89,154.06 | 2,154 | BSRK699 |
| 0.10% | GMAB | GENMAB A/S -SP ADR | -- | $88,637.79 | 2,617 | BBC9WC7 |
| 0.10% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $88,485.97 | 5,903 | BFWLC09 |
| 0.10% | NRIX | NURIX THERAPEUTICS INC | -- | $85,904.34 | 4,538 | BMVLGP2 |
| 0.10% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $85,088.90 | 3,770 | BMX9K07 |
| 0.10% | VCEL | VERICEL CORP | -- | $83,918.25 | 2,265 | BSBMN89 |
| 0.10% | ANIP | ANI PHARMACEUTICALS INC | -- | $82,773.68 | 1,006 | BCDWBX6 |
| 0.10% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $82,655.76 | 5,258 | BRJZSK0 |
| 0.09% | ZYME | ZYMEWORKS INC | -- | $80,132.00 | 3,350 | BPCQZY9 |
| 0.09% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $79,648.77 | 3,891 | BN7Q7R7 |
| 0.09% | UPB | UPSTREAM BIO INC | -- | $78,892.00 | 2,420 | BRCFFK6 |
| 0.09% | HROW | HARROW INC | -- | $78,241.02 | 1,658 | BHNDW86 |
| 0.09% | STOK | STOKE THERAPEUTICS INC | -- | $78,193.06 | 2,557 | BJQ05Z6 |
| 0.09% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $78,049.20 | 2,022 | BRXB0C0 |
| 0.09% | MNKD | MANNKIND CORP | -- | $77,538.72 | 13,748 | BF081J4 |
| 0.09% | ARDX | ARDELYX INC | -- | $76,588.16 | 10,879 | BN89V40 |
| 0.09% | PHVS | PHARVARIS NV | -- | $74,568.00 | 2,868 | BMZ2X38 |
| 0.09% | SION | SIONNA THERAPEUTICS INC | -- | $73,546.38 | 1,998 | BQKXDX4 |
| 0.08% | MBX | MBX BIOSCIENCES INC | -- | $72,983.10 | 2,010 | BQXJKH2 |
| 0.08% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $72,585.80 | 2,611 | BCBVTX1 |
| 0.08% | FTRE | FORTREA HOLDINGS INC | -- | $71,859.69 | 4,137 | BRXYZ57 |
| 0.08% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $69,930.85 | 2,915 | BP7KZP7 |
| 0.08% | TYRA | TYRA BIOSCIENCES INC | -- | $68,827.09 | 2,389 | BMVNDH9 |
| 0.08% | NVCR | NOVOCURE LTD | -- | $68,441.10 | 5,014 | BYSS4X4 |
| 0.08% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $68,417.75 | 2,657 | BMFD115 |
| 0.08% | ORKA | ORUKA THERAPEUTICS INC | -- | $67,913.78 | 2,167 | BKVF0J2 |
| 0.08% | ALVO | ALVOTECH SA | -- | $67,692.45 | 14,015 | BPNTJ34 |
| 0.08% | KOD | KODIAK SCIENCES INC | -- | $67,260.00 | 2,375 | BFXC933 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $66,901.20 | 1,415 | BX7RSN3 |
| 0.08% | PGEN | PRECIGEN INC | -- | $65,915.19 | 15,807 | BKM5C84 |
| 0.08% | MNMD | MIND MEDICINE MINDMED INC | -- | $65,576.70 | 4,410 | BPQYY97 |
| 0.08% | INVA | INNOVIVA INC | -- | $65,319.48 | 3,348 | BDDXF67 |
| 0.08% | TRVI | TREVI THERAPEUTICS INC | -- | $64,815.89 | 5,741 | BJH9ZN0 |
| 0.07% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $63,625.50 | 9,426 | 2100362 |
| 0.07% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $63,081.90 | 1,953 | BLCD809 |
| 0.07% | NVAX | NOVAVAX INC | -- | $63,074.25 | 7,275 | BJDQXG4 |
| 0.07% | TNGX | TANGO THERAPEUTICS INC | -- | $62,953.20 | 6,030 | BP2P6L0 |
| 0.07% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $61,954.20 | 4,917 | BPCK358 |
| 0.07% | RLAY | RELAY THERAPEUTICS INC | -- | $61,614.40 | 7,760 | BN2R582 |
| 0.07% | NTLA | INTELLIA THERAPEUTICS INC | -- | $60,824.94 | 5,181 | BYZM6C2 |
| 0.07% | TSHA | TAYSHA GENE THERAPIES INC | -- | $60,093.60 | 12,264 | BNC1BX1 |
| 0.07% | QURE | UNIQURE NV | -- | $59,963.50 | 2,789 | BJFSR88 |
| 0.07% | ATAI | ATAIBECKLEY INC | -- | $59,677.87 | 16,261 | BWJDYK1 |
| 0.07% | ANAB | ANAPTYSBIO INC | -- | $59,675.00 | 1,240 | BDRW1L7 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $59,496.78 | 2,058 | BNFWZS4 |
| 0.07% | EYPT | EYEPOINT INC | -- | $59,052.51 | 3,707 | BMGS7L1 |
| 0.07% | RAPP | RAPPORT THERAPEUTICS INC | -- | $57,885.60 | 2,136 | BR3T9B6 |
| 0.07% | ABCL | ABCELLERA BIOLOGICS INC | -- | $57,307.67 | 13,421 | BL53SR3 |
| 0.07% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $57,277.59 | 7,429 | BLR7H87 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $56,052.20 | 11,926 | BMFJJ97 |
| 0.06% | SVRA | SAVARA INC | -- | $53,931.20 | 9,110 | BYXGN81 |
| 0.06% | SEPN | SEPTERNA INC | -- | $52,891.90 | 2,005 | BQNKXX2 |
| 0.06% | ZBIO | ZENAS BIOPHARMA INC | -- | $51,832.71 | 2,403 | BQB42H3 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $51,809.48 | 1,307 | BKLCWZ3 |
| 0.06% | SPRY | ARS PHARMACEUTICALS INC | -- | $50,058.06 | 4,426 | BMCR7V2 |
| 0.06% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $49,781.55 | 3,185 | BJLKVS6 |
| 0.06% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $48,406.89 | 4,571 | BLB0YH0 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $48,284.08 | 5,462 | B8K7T65 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $47,705.28 | 651 | BNSP8K3 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $46,149.10 | 2,270 | BMNDK09 |
| 0.05% | XNCR | XENCOR INC | -- | $44,566.18 | 3,197 | BGCYWN8 |
| 0.05% | VTYX | VENTYX BIOSCIENCES INC | -- | $44,282.70 | 3,195 | BMG99Y1 |
| 0.05% | ORIC | ORIC PHARMACEUTICALS INC | -- | $44,220.54 | 4,361 | BKVDFF7 |
| 0.05% | GHRS | GH RESEARCH PLC | -- | $43,987.68 | 2,777 | BP6C0S2 |
| 0.05% | BCAX | BICARA THERAPEUTICS INC | -- | $43,001.09 | 2,453 | BQB42F1 |
| 0.05% | RAPT | RAPT THERAPEUTICS INC | -- | $42,268.46 | 1,241 | BTJZB49 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $41,768.90 | 17,774 | BF0DMK7 |
| 0.05% | PCRX | PACIRA BIOSCIENCES INC | -- | $41,601.60 | 1,926 | B3X26D8 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $41,563.68 | 2,096 | BZ7PJQ1 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $40,816.14 | 8,611 | BZ0QMB7 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $40,600.56 | 1,848 | BMGTLY5 |
| 0.05% | ANNX | ANNEXON INC | -- | $40,111.20 | 6,480 | BMVV9R5 |
| 0.05% | OMER | OMEROS CORP | -- | $40,068.50 | 3,175 | B4NB858 |
| 0.05% | VIR | VIR BIOTECHNOLOGY INC | -- | $39,304.99 | 6,229 | BK4PZ38 |
| 0.05% | MESO | MESOBLAST LTD- SPON ADR | -- | $39,000.96 | 2,196 | BQS7491 |
| 0.04% | GERN | GERON CORP | -- | $37,442.42 | 28,582 | 2370381 |
| 0.04% | JANX | JANUX THERAPEUTICS INC | -- | $37,136.47 | 2,693 | BMFX8Y7 |
| 0.04% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $37,020.90 | 915 | BL95N25 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $35,817.69 | 3,889 | BYZD465 |
| 0.04% | ARVN | ARVINAS INC | -- | $35,346.04 | 2,876 | BDZ30Q0 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $35,319.90 | 10,703 | BBNBTD2 |
| 0.04% | PSNL | PERSONALIS INC | -- | $34,874.16 | 3,972 | BJQ0608 |
| 0.04% | RGNX | REGENXBIO INC | -- | $34,118.35 | 2,267 | BZ0G875 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $33,824.16 | 2,264 | BD06CS0 |
| 0.04% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $33,793.12 | 7,283 | B3MZ6K5 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $33,621.12 | 8,082 | BPBJFM7 |
| 0.04% | BIOA | BIOAGE LABS INC | -- | $33,228.14 | 1,606 | BT9K6D8 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $32,816.16 | 1,753 | BD9GVY0 |
| 0.04% | CMPS | COMPASS PATHWAYS PLC | -- | $31,094.03 | 4,219 | BMC3HS7 |
| 0.04% | CTMX | CYTOMX THERAPEUTICS INC | -- | $31,026.74 | 7,586 | BYWVTY5 |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $30,861.48 | 813 | BQD3J33 |
| 0.03% | IVVD | INVIVYD INC | -- | $29,032.38 | 12,407 | BM8NHS1 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $28,791.21 | 13,517 | B4N8MH9 |
| 0.03% | CGEM | CULLINAN THERAPEUTICS INC | -- | $28,380.85 | 2,645 | BM90J52 |
| 0.03% | REPL | REPLIMUNE GROUP INC | -- | $28,236.48 | 3,512 | BDDVW37 |
| 0.03% | GOSS | GOSSAMER BIO INC | -- | $27,565.58 | 10,363 | BJ0CK86 |
| 0.03% | KROS | KEROS THERAPEUTICS INC | -- | $26,598.00 | 1,364 | BM7V485 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $26,597.52 | 3,604 | BFYQFJ2 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $26,105.88 | 6,494 | BMCWKZ2 |
| 0.03% | CRMD | CORMEDIX INC | -- | $24,907.68 | 3,528 | BJ0LT31 |
| 0.03% | FULC | FULCRUM THERAPEUTICS INC | -- | $24,835.75 | 2,423 | BJDX8Z9 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $24,403.50 | 2,550 | BMFK3H6 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $24,281.24 | 3,268 | BQ6C357 |
| 0.03% | LENZ | LENZ THERAPEUTICS INC | -- | $23,256.60 | 1,401 | BQV0J03 |
| 0.03% | LYEL | LYELL IMMUNOPHARMA INC | -- | $22,524.50 | 950 | BTNMG41 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $22,487.32 | 2,521 | BLFBZ32 |
| 0.03% | ABSI | ABSCI CORP | -- | $22,286.23 | 6,733 | BN94K69 |
| 0.03% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $21,736.00 | 3,344 | BYP80F1 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $21,650.78 | 2,411 | B91XRN2 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $21,546.00 | 648 | B292NQ7 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $21,159.60 | 3,206 | 2107437 |
| 0.02% | KMDA | KAMADA LTD | -- | $20,354.04 | 2,583 | B2Q9833 |
| 0.02% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $20,113.74 | 2,559 | BKLXFX5 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $19,686.24 | 2,646 | B12W3P6 |
| 0.02% | ETON | ETON PHARMACEUTICALS INC | -- | $18,891.73 | 1,201 | BGL0JK3 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $18,734.72 | 4,672 | BFY7DC4 |
| 0.02% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $18,683.46 | 5,463 | BYVQJ96 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $18,560.00 | 4,000 | BYTYP72 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $18,411.00 | 4,845 | BDFKQ07 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $17,998.08 | 3,488 | BQHN6C7 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $17,897.06 | 1,711 | BP81RK8 |
| 0.02% | PEPG | PEPGEN INC | -- | $17,242.40 | 3,079 | BMTX3D7 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $17,016.90 | 1,965 | BSMLR16 |
| 0.02% | NBP | NOVABRIDGE BIOSCIENCES | -- | $16,990.75 | 4,655 | BKRRKY7 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $16,963.96 | 1,292 | B9L5200 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $16,913.76 | 2,532 | BMF7DT9 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $16,635.20 | 4,496 | BZC0D70 |
| 0.02% | EOLS | EVOLUS INC | -- | $16,599.44 | 2,902 | BDRJH21 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $16,550.50 | 838 | BPBPCG8 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $16,501.68 | 10,062 | BFZNYB7 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $16,009.34 | 7,481 | BN4JN37 |
| 0.02% | CADL | CANDEL THERAPEUTICS INC | -- | $15,067.54 | 2,458 | BP0TQC5 |
| 0.02% | AARD | AARDVARK THERAPEUTICS INC | -- | $15,005.25 | 975 | BTXQTX3 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $14,385.58 | 2,843 | BP81R42 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $14,077.44 | 2,256 | B7F2TY6 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $13,447.28 | 2,072 | BKDQKM6 |
| 0.02% | ACRS | ACLARIS THERAPEUTICS INC | -- | $13,146.21 | 4,851 | BYV2W40 |
| 0.01% | LRMR | LARIMAR THERAPEUTICS INC | -- | $12,760.56 | 3,832 | BMXNGZ6 |
| 0.01% | LFCR | LIFECORE BIOMEDICAL INC | -- | $12,517.88 | 1,678 | 2517058 |
| 0.01% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $12,422.82 | 2,102 | BL5B6Z1 |
| 0.01% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $12,303.97 | 8,981 | BFMLGR4 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $12,277.98 | 3,498 | BLN9Z50 |
| 0.01% | OABI | OMNIAB INC | -- | $12,245.50 | 6,445 | BN13S71 |
| 0.01% | IMRX | IMMUNEERING CORP - CLASS A | -- | $11,954.29 | 2,891 | BMVBZF5 |
| 0.01% | MENS | JYONG BIOTECH LTD | -- | $11,914.00 | 3,404 | BPTK6Z2 |
| 0.01% | NGNE | NEUROGENE INC | -- | $11,746.35 | 693 | BS2F741 |
| 0.01% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $11,270.60 | 1,034 | BPRBTY7 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $11,118.85 | 8,755 | BNR5QT9 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $10,819.84 | 2,528 | BPRB2N7 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $10,620.84 | 2,642 | BY7RB53 |
| 0.01% | VOR | VOR BIOPHARMA INC | -- | $10,171.46 | 754 | BRJJYT3 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $10,025.40 | 4,340 | BKX9NQ0 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $9,871.52 | 2,396 | BP7L561 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $9,629.04 | 1,272 | BKC9SX3 |
| 0.01% | HUMA | HUMACYTE INC | -- | $9,307.35 | 8,385 | BMYTJP4 |
| 0.01% | CABA | CABALETTA BIO INC | -- | $9,266.50 | 4,310 | BK5MWR1 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $9,200.40 | 5,412 | BRK0149 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $9,135.39 | 4,371 | BZ8FPH3 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $8,619.48 | 1,388 | BP2NYN2 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $7,015.25 | 2,551 | BKTV702 |
| 0.01% | CDXS | CODEXIS INC | -- | $6,916.95 | 4,045 | B5LL2C2 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $6,652.56 | 4,184 | BNYJR68 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $6,201.14 | 4,367 | BNNXX18 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $5,658.35 | 7,455 | BNNXX52 |
| 0.01% | PYXS | PYXIS ONCOLOGY INC | -- | $5,241.44 | 2,788 | BLBR8D5 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $10.63 | 01 | BTFHQP5 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 38.81% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 33,468,907 | -- | 5,795 | -- |
| 32.67% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 28,172,791 | -- | 4,878 | -- |
| 22.08% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 19,047,533 | -- | 3,298 | -- |
| 16.63% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,346,292 | -- | 2,484 | -- |
| 15.40% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 13,277,829 | -- | 2,299 | -- |
| 4.24% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,655,879 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $25,841,740.89 | 25,841,741 | -- |
Index
as of 12/31/2025
- Total Number of Companies262
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$7.32 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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