BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 10/31/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 20.05% | 41.93% | 51.59% | 42.58% | 20.67% | 9.55% | 2.60% | 0.91% | 15.79% | 04/07/2010 |
| BIB Market Price | 20.06% | 42.12% | 51.73% | 42.51% | 20.92% | 9.51% | 2.55% | 0.91% | 15.79% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 11/13/2025- NAV $74.49
- NAV Change $-1.31
- Market Price $74.47
- Market Price Change $-1.60
- Trading Volume (M) 17,946
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 11/13/2025- NAV $74.49
- NAV Change $-1.31
- Market Price $74.47
- Market Price Change $-1.60
- Trading Volume (M) 17,946
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 11/13/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.28% | AMGN | AMGEN INC | -- | $4,010,496.00 | 11,936 | 2023607 |
| 5.02% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $3,816,823.68 | 8,784 | 2931034 |
| 5.01% | GILD | GILEAD SCIENCES INC | -- | $3,806,455.60 | 30,403 | 2369174 |
| 3.92% | REGN | REGENERON PHARMACEUTICALS | -- | $2,980,117.12 | 4,288 | 2730190 |
| 3.22% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,449,622.12 | 5,396 | B00FWN1 |
| 2.51% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $1,904,494.73 | 21,493 | 2989044 |
| 2.21% | INSM | INSMED INC | -- | $1,675,483.04 | 8,774 | 2614487 |
| 1.49% | ARGX | ARGENX SE - ADR | -- | $1,131,605.37 | 1,269 | BDVLM39 |
| 1.32% | BIIB | BIOGEN INC | -- | $1,002,546.78 | 6,086 | 2455965 |
| 1.14% | UTHR | UNITED THERAPEUTICS CORP | -- | $867,737.10 | 1,877 | 2430412 |
| 1.12% | INCY | INCYTE CORP | -- | $854,348.05 | 8,105 | 2471950 |
| 1.01% | ILMN | ILLUMINA INC | -- | $765,033.47 | 6,379 | 2613990 |
| 0.93% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $708,888.42 | 17,942 | BMVP7Y0 |
| 0.91% | MEDP | MEDPACE HOLDINGS INC | -- | $690,070.44 | 1,167 | BDCBC61 |
| 0.78% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $593,238.98 | 4,115 | 2623911 |
| 0.77% | SNY | SANOFI-ADR | -- | $582,910.58 | 11,137 | 2964557 |
| 0.77% | ROIV | ROIVANT SCIENCES LTD | -- | $582,711.52 | 28,342 | BMW4NZ9 |
| 0.74% | SMMT | SUMMIT THERAPEUTICS INC | -- | $562,974.06 | 30,831 | BMTVQS7 |
| 0.69% | VTRS | VIATRIS INC | -- | $527,891.26 | 48,386 | BMWS3X9 |
| 0.69% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $521,079.80 | 2,524 | BV9G6B8 |
| 0.68% | BBIO | BRIDGEBIO PHARMA INC | -- | $516,055.92 | 7,932 | BK1KWG8 |
| 0.68% | ONC | BEONE MEDICINES LTD-ADR | -- | $513,862.20 | 1,395 | BYYWPW6 |
| 0.66% | RVMD | REVOLUTION MEDICINES INC | -- | $499,460.04 | 7,758 | BL71K91 |
| 0.64% | GH | GUARDANT HEALTH INC | -- | $487,311.01 | 5,177 | BFXC911 |
| 0.63% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $475,795.32 | 924 | BD59BS7 |
| 0.63% | TEM | TEMPUS AI INC | -- | $475,647.94 | 7,001 | BSLSJJ0 |
| 0.62% | EXEL | EXELIXIS INC | -- | $473,134.20 | 11,172 | 2576941 |
| 0.61% | IONS | IONIS PHARMACEUTICALS INC | -- | $461,851.92 | 6,613 | BDJ0LS6 |
| 0.57% | BNTX | BIONTECH SE-ADR | -- | $433,595.12 | 4,174 | BK6H543 |
| 0.57% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $432,079.18 | 7,969 | 2437071 |
| 0.53% | MRNA | MODERNA INC | -- | $403,054.08 | 16,148 | BGSXTS3 |
| 0.50% | RNA | AVIDITY BIOSCIENCES INC | -- | $378,214.76 | 5,339 | BMWHPY1 |
| 0.47% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $356,542.36 | 2,516 | B4Q5ZN4 |
| 0.45% | HALO | HALOZYME THERAPEUTICS INC | -- | $345,556.26 | 4,854 | 2975098 |
| 0.43% | CYTK | CYTOKINETICS INC | -- | $325,437.84 | 4,967 | BBBSBJ5 |
| 0.40% | MRUS | MERUS NV | -- | $301,499.04 | 3,138 | BZBY005 |
| 0.37% | AXSM | AXSOME THERAPEUTICS INC | -- | $284,692.80 | 2,072 | BYZR4X4 |
| 0.35% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $264,464.62 | 2,758 | BF2YWG4 |
| 0.34% | NUVL | NUVALENT INC-A | -- | $261,979.56 | 2,767 | BMVBZD3 |
| 0.33% | PTCT | PTC THERAPEUTICS INC | -- | $247,260.05 | 3,299 | B17VCN9 |
| 0.32% | PCVX | VAXCYTE INC | -- | $245,423.40 | 5,388 | BKPVGH6 |
| 0.32% | KRYS | KRYSTAL BIOTECH INC | -- | $241,452.00 | 1,200 | BD6JX35 |
| 0.31% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $236,102.46 | 5,739 | BYQBFJ8 |
| 0.28% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $214,842.44 | 2,581 | BDCBCD8 |
| 0.28% | ALKS | ALKERMES PLC | -- | $212,480.52 | 6,852 | B3P6D26 |
| 0.26% | ACLX | ARCELLX INC | -- | $201,153.42 | 2,301 | BPCJ1Q2 |
| 0.26% | COGT | COGENT BIOSCIENCES INC | -- | $196,180.17 | 5,799 | BLR6XK8 |
| 0.25% | CRSP | CRISPR THERAPEUTICS AG | -- | $192,838.03 | 3,773 | BDHF4K6 |
| 0.25% | KYMR | KYMERA THERAPEUTICS INC | -- | $188,853.84 | 2,968 | BMPRZV5 |
| 0.24% | AKRO | AKERO THERAPEUTICS INC | -- | $179,944.00 | 3,320 | BK7Y2V9 |
| 0.22% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $170,190.66 | 4,673 | BP8JSP4 |
| 0.22% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $165,527.28 | 7,002 | 2713317 |
| 0.22% | IMVT | IMMUNOVANT INC | -- | $165,057.06 | 7,233 | BJRFSB7 |
| 0.22% | LGND | LIGAND PHARMACEUTICALS | -- | $163,833.78 | 814 | 2501578 |
| 0.21% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $161,867.01 | 3,907 | BDD19F8 |
| 0.21% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $155,820.00 | 875 | BQ721R4 |
| 0.20% | ADMA | ADMA BIOLOGICS INC | -- | $155,492.80 | 9,904 | B9NSBM2 |
| 0.20% | INDV | INDIVIOR PLC | -- | $154,489.57 | 5,179 | BP0BQQ5 |
| 0.20% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $150,163.20 | 13,035 | BFNF1D6 |
| 0.19% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $144,386.25 | 2,085 | BJDX8Y8 |
| 0.17% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $131,632.90 | 4,001 | BJ62Z18 |
| 0.17% | VCYT | VERACYTE INC | -- | $130,175.55 | 3,265 | BFTWZY0 |
| 0.17% | XENE | XENON PHARMACEUTICALS INC | -- | $128,087.96 | 3,199 | BRJ3GY4 |
| 0.17% | TARS | TARSUS PHARMACEUTICALS INC | -- | $127,000.03 | 1,751 | BMH5RL1 |
| 0.17% | IRON | DISC MEDICINE INC | -- | $125,685.76 | 1,444 | BMGJZJ8 |
| 0.16% | TVTX | TRAVERE THERAPEUTICS INC | -- | $125,325.22 | 3,698 | BLFGJD5 |
| 0.16% | GRAL | GRAIL INC | -- | $124,633.60 | 1,498 | BSLSSX7 |
| 0.16% | MLYS | MINERALYS THERAPEUTICS INC | -- | $121,930.37 | 2,753 | BP9N0G0 |
| 0.16% | APGE | APOGEE THERAPEUTICS INC | -- | $120,587.55 | 1,915 | BM9HHL5 |
| 0.16% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $120,009.37 | 3,991 | BFZQ0L8 |
| 0.16% | FOLD | AMICUS THERAPEUTICS INC | -- | $120,007.72 | 12,794 | B19FQ48 |
| 0.16% | CGON | CG ONCOLOGY INC | -- | $119,548.16 | 3,166 | BRBCSP4 |
| 0.15% | IDYA | IDEAYA BIOSCIENCES INC | -- | $115,697.52 | 3,636 | BK0VHF6 |
| 0.15% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $113,774.22 | 4,977 | BKX9VD3 |
| 0.15% | DYN | DYNE THERAPEUTICS INC | -- | $111,172.32 | 5,904 | BN15WD1 |
| 0.14% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $108,317.93 | 3,493 | BMX9K07 |
| 0.14% | DNLI | DENALI THERAPEUTICS INC | -- | $104,100.50 | 6,070 | BD2B4V0 |
| 0.14% | APLS | APELLIS PHARMACEUTICALS INC | -- | $103,863.83 | 5,243 | BYTQ6X1 |
| 0.14% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $103,500.76 | 2,329 | B72ZBG4 |
| 0.14% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $103,360.60 | 3,980 | BLB0YQ9 |
| 0.14% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $102,606.48 | 2,412 | BCBVTX1 |
| 0.12% | BEAM | BEAM THERAPEUTICS INC | -- | $90,972.00 | 4,200 | BK6L288 |
| 0.12% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $89,350.66 | 6,319 | BJ5FZ74 |
| 0.12% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $89,276.24 | 4,372 | BKY5JZ8 |
| 0.11% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $86,590.00 | 2,474 | BQS9486 |
| 0.11% | VCEL | VERICEL CORP | -- | $83,385.12 | 2,093 | BSBMN89 |
| 0.11% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $83,162.08 | 5,464 | BFWLC09 |
| 0.11% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $81,815.94 | 2,386 | BKSGZN7 |
| 0.11% | OCUL | OCULAR THERAPEUTIX INC | -- | $80,802.99 | 7,221 | BNZB1X8 |
| 0.10% | IBRX | IMMUNITYBIO INC | -- | $78,462.00 | 39,231 | BNSP0B8 |
| 0.10% | TXG | 10X GENOMICS INC-CLASS A | -- | $77,662.50 | 4,750 | BKS3RS7 |
| 0.10% | AVDL | AVADEL PHARMACEUTICALS | -- | $77,517.96 | 4,029 | BDGMC59 |
| 0.10% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $76,792.55 | 17,735 | BM9FJ13 |
| 0.10% | ANIP | ANI PHARMACEUTICALS INC | -- | $76,095.00 | 900 | BCDWBX6 |
| 0.10% | TERN | TERNS PHARMACEUTICALS INC | -- | $75,249.90 | 3,630 | BMDJ0C9 |
| 0.10% | VERA | VERA THERAPEUTICS INC | -- | $75,123.76 | 2,648 | BL55460 |
| 0.10% | TWST | TWIST BIOSCIENCE CORP | -- | $74,899.50 | 2,505 | BGKG6G7 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $72,683.16 | 1,804 | BRXB0C0 |
| 0.10% | SRPT | SAREPTA THERAPEUTICS INC | -- | $72,295.74 | 4,057 | B8DPDT7 |
| 0.09% | ALVO | ALVOTECH SA | -- | $71,699.28 | 12,989 | BPNTJ34 |
| 0.09% | QURE | UNIQURE NV | -- | $69,266.22 | 2,283 | BJFSR88 |
| 0.09% | JANX | JANUX THERAPEUTICS INC | -- | $68,485.24 | 2,494 | BMFX8Y7 |
| 0.08% | MNKD | MANNKIND CORP | -- | $64,566.45 | 12,735 | BF081J4 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $60,665.04 | 1,308 | BX7RSN3 |
| 0.08% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $60,119.70 | 8,713 | 2100362 |
| 0.08% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $59,592.82 | 3,577 | BN7Q7R7 |
| 0.08% | STOK | STOKE THERAPEUTICS INC | -- | $59,309.25 | 2,275 | BJQ05Z6 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $58,784.94 | 1,662 | BLCD809 |
| 0.08% | ARDX | ARDELYX INC | -- | $58,300.00 | 10,000 | BN89V40 |
| 0.08% | HROW | HARROW INC | -- | $58,161.15 | 1,535 | BHNDW86 |
| 0.08% | INVA | INNOVIVA INC | -- | $58,097.40 | 2,617 | BDDXF67 |
| 0.08% | TRVI | TREVI THERAPEUTICS INC | -- | $57,918.84 | 5,054 | BJH9ZN0 |
| 0.08% | ZYME | ZYMEWORKS INC | -- | $57,720.00 | 3,120 | BPCQZY9 |
| 0.07% | SYRE | SPYRE THERAPEUTICS INC | -- | $56,710.78 | 2,506 | BQBBDY8 |
| 0.07% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $54,304.56 | 4,866 | BRJZSK0 |
| 0.07% | NVCR | NOVOCURE LTD | -- | $52,803.20 | 4,640 | BYSS4X4 |
| 0.07% | GMAB | GENMAB A/S -SP ADR | -- | $52,617.60 | 1,740 | BBC9WC7 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $50,867.73 | 1,929 | BNFWZS4 |
| 0.07% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $49,803.39 | 2,457 | BMFD115 |
| 0.07% | CVAC | CUREVAC NV | -- | $49,528.50 | 9,345 | BN4RD42 |
| 0.06% | ORIC | ORIC PHARMACEUTICALS INC | -- | $49,125.70 | 4,030 | BKVDFF7 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $48,663.78 | 6,703 | BLR7H87 |
| 0.06% | PGEN | PRECIGEN INC | -- | $47,728.90 | 12,365 | BKM5C84 |
| 0.06% | NVAX | NOVAVAX INC | -- | $47,584.40 | 6,740 | BJDQXG4 |
| 0.06% | RLAY | RELAY THERAPEUTICS INC | -- | $46,149.75 | 7,155 | BN2R582 |
| 0.06% | URGN | UROGEN PHARMA LTD | -- | $45,950.32 | 1,921 | BZ7PJQ1 |
| 0.06% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $45,941.58 | 3,699 | BPCK358 |
| 0.06% | TSHA | TAYSHA GENE THERAPIES INC | -- | $45,393.20 | 11,320 | BNC1BX1 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $44,921.24 | 602 | BNSP8K3 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $44,898.86 | 12,403 | BL53SR3 |
| 0.06% | PCRX | PACIRA BIOSCIENCES INC | -- | $44,051.30 | 1,865 | B3X26D8 |
| 0.06% | WVE | WAVE LIFE SCIENCES LTD | -- | $44,048.68 | 6,604 | BYZG9R0 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $44,048.10 | 5,063 | B8K7T65 |
| 0.06% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $43,688.70 | 2,942 | BJLKVS6 |
| 0.06% | ZLAB | ZAI LAB LTD-ADR | -- | $43,155.78 | 1,986 | BD9GVY0 |
| 0.05% | XNCR | XENCOR INC | -- | $41,424.39 | 2,961 | BGCYWN8 |
| 0.05% | CSTL | CASTLE BIOSCIENCES INC | -- | $41,012.24 | 1,202 | BKLCWZ3 |
| 0.05% | ORKA | ORUKA THERAPEUTICS INC | -- | $40,941.76 | 1,552 | BKVF0J2 |
| 0.05% | NRIX | NURIX THERAPEUTICS INC | -- | $39,452.82 | 3,174 | BMVLGP2 |
| 0.05% | SANA | SANA BIOTECHNOLOGY INC | -- | $39,297.42 | 10,737 | BMFJJ97 |
| 0.05% | ANAB | ANAPTYSBIO INC | -- | $38,681.38 | 1,163 | BDRW1L7 |
| 0.05% | NTLA | INTELLIA THERAPEUTICS INC | -- | $38,616.18 | 4,454 | BYZM6C2 |
| 0.05% | FTRE | FORTREA HOLDINGS INC | -- | $38,498.74 | 3,767 | BRXYZ57 |
| 0.05% | KURA | KURA ONCOLOGY INC | -- | $38,469.36 | 3,602 | BYZD465 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $37,771.50 | 845 | BL95N25 |
| 0.05% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $37,612.50 | 4,250 | BLB0YH0 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $37,515.50 | 2,090 | BMNDK09 |
| 0.05% | RAPP | RAPPORT THERAPEUTICS INC | -- | $37,375.05 | 1,515 | BR3T9B6 |
| 0.05% | MNMD | MIND MEDICINE MINDMED INC | -- | $36,750.80 | 3,160 | BPQYY97 |
| 0.05% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $36,702.16 | 2,563 | BP7KZP7 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $36,283.92 | 7,957 | BZ0QMB7 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $36,195.79 | 15,019 | BF0DMK7 |
| 0.05% | TNGX | TANGO THERAPEUTICS INC | -- | $35,658.68 | 4,619 | BP2P6L0 |
| 0.05% | CRMD | CORMEDIX INC | -- | $34,739.79 | 3,099 | BJ0LT31 |
| 0.05% | TYRA | TYRA BIOSCIENCES INC | -- | $34,531.85 | 2,215 | BMVNDH9 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $34,489.41 | 4,101 | BMCR7V2 |
| 0.04% | AVBP | ARRIVENT BIOPHARMA INC | -- | $33,121.44 | 1,683 | BMGTLY5 |
| 0.04% | EYPT | EYEPOINT PHARMACEUTICALS INC | -- | $32,941.62 | 2,862 | BMGS7L1 |
| 0.04% | VIR | VIR BIOTECHNOLOGY INC | -- | $31,534.55 | 5,765 | BK4PZ38 |
| 0.04% | LENZ | LENZ THERAPEUTICS INC | -- | $31,337.67 | 1,183 | BQV0J03 |
| 0.04% | ARVN | ARVINAS INC | -- | $30,835.64 | 3,047 | BDZ30Q0 |
| 0.04% | SVRA | SAVARA INC | -- | $30,565.50 | 7,175 | BYXGN81 |
| 0.04% | GERN | GERON CORP | -- | $30,450.85 | 26,479 | 2370381 |
| 0.04% | ERAS | ERASCA INC | -- | $29,905.96 | 11,774 | BNLYBF3 |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $29,710.60 | 745 | BQD3J33 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $29,213.36 | 1,958 | BQS7491 |
| 0.04% | ATXS | ASTRIA THERAPEUTICS INC | -- | $29,146.92 | 2,343 | BMYRFN8 |
| 0.04% | KROS | KEROS THERAPEUTICS INC | -- | $29,133.20 | 1,684 | BM7V485 |
| 0.04% | REPL | REPLIMUNE GROUP INC | -- | $29,104.18 | 3,241 | BDDVW37 |
| 0.04% | PSNL | PERSONALIS INC | -- | $27,968.00 | 3,680 | BJQ0608 |
| 0.04% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $27,571.88 | 3,338 | BFYQFJ2 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $27,345.01 | 2,089 | BD06CS0 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $26,600.70 | 5,019 | BYVQJ96 |
| 0.03% | ESPR | ESPERION THERAPEUTICS INC | -- | $24,772.24 | 8,369 | BBNBTD2 |
| 0.03% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $24,752.00 | 3,094 | BYP80F1 |
| 0.03% | RGNX | REGENXBIO INC | -- | $24,385.80 | 2,095 | BZ0G875 |
| 0.03% | PRME | PRIME MEDICINE INC | -- | $24,169.14 | 7,258 | BPBJFM7 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $22,731.94 | 2,233 | B91XRN2 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $22,713.80 | 6,740 | B3MZ6K5 |
| 0.03% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $22,613.12 | 2,848 | BMZ4LN0 |
| 0.03% | LXRX | LEXICON PHARMACEUTICALS INC | -- | $21,720.96 | 15,084 | BWFZX59 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $21,515.13 | 2,331 | BLFBZ32 |
| 0.03% | ALMS | ALUMIS INC | -- | $21,230.88 | 4,021 | BPLQG36 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $20,321.21 | 12,467 | B4N8MH9 |
| 0.03% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $20,273.47 | 3,563 | BYTYP72 |
| 0.03% | CGEM | CULLINAN THERAPEUTICS INC | -- | $20,261.50 | 2,450 | BM90J52 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $20,139.03 | 3,807 | BMC3HS7 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $20,137.60 | 2,240 | BQ6C357 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $19,922.64 | 1,938 | BKLXFX5 |
| 0.03% | EOLS | EVOLUS INC | -- | $19,795.82 | 2,686 | BDRJH21 |
| 0.03% | HCM | HUTCHMED CHINA-ADR | -- | $19,567.02 | 1,289 | BYXV9H7 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $19,519.50 | 6,006 | BMCWKZ2 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $18,768.04 | 596 | B292NQ7 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $18,079.49 | 6,721 | BN4JN37 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $18,069.76 | 2,972 | 2107437 |
| 0.02% | OMER | OMEROS CORP | -- | $17,741.00 | 2,825 | B4NB858 |
| 0.02% | DSGN | DESIGN THERAPEUTICS INC | -- | $16,682.78 | 2,363 | BMFK3H6 |
| 0.02% | ABSI | ABSCI CORP | -- | $16,386.48 | 6,207 | BN94K69 |
| 0.02% | NGNE | NEUROGENE INC | -- | $15,735.06 | 594 | BS2F741 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $14,875.84 | 3,664 | BFY7DC4 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $14,250.81 | 2,577 | BP81R42 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $14,201.60 | 4,480 | BDFKQ07 |
| 0.02% | LYEL | LYELL IMMUNOPHARMA INC | -- | $13,910.59 | 799 | BTNMG41 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $13,901.90 | 3,233 | BQHN6C7 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $13,872.40 | 1,580 | BP81RK8 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $13,642.08 | 776 | BPBPCG8 |
| 0.02% | AMRN | AMARIN CORP PLC -ADR | -- | $13,601.72 | 836 | BN72KB0 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $13,487.08 | 1,949 | BL5B6Z1 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $13,459.41 | 4,167 | BZC0D70 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $12,672.00 | 1,920 | BKDQKM6 |
| 0.02% | ANNX | ANNEXON INC | -- | $12,223.48 | 4,561 | BMVV9R5 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $11,682.79 | 3,551 | BMXNGZ6 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $11,631.60 | 1,795 | BSMLR16 |
| 0.02% | PYXS | PYXIS ONCOLOGY INC | -- | $11,527.04 | 2,573 | BLBR8D5 |
| 0.01% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $11,050.80 | 9,209 | BFZNYB7 |
| 0.01% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $10,654.72 | 8,324 | BFMLGR4 |
| 0.01% | VNDA | VANDA PHARMACEUTICALS INC | -- | $10,637.34 | 2,451 | B12W3P6 |
| 0.01% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $10,407.36 | 888 | B9L5200 |
| 0.01% | FHTX | FOGHORN THERAPEUTICS INC | -- | $10,232.92 | 2,347 | BMF7DT9 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $10,082.70 | 3,295 | BLN9Z50 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $9,839.03 | 2,221 | BP7L561 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $9,481.82 | 3,733 | BZ8FPH3 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $9,157.98 | 2,301 | BY7RB53 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $8,749.02 | 1,126 | BKC9SX3 |
| 0.01% | HUMA | HUMACYTE INC | -- | $7,823.06 | 6,574 | BMYTJP4 |
| 0.01% | RNAC | CARTESIAN THERAPEUTICS INC | -- | $7,815.63 | 1,081 | BQB9HM8 |
| 0.01% | OABI | OMNIAB INC | -- | $7,738.32 | 5,091 | BN13S71 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $7,239.75 | 2,955 | BKX9NQ0 |
| 0.01% | MXCT | MAXCYTE INC | -- | $6,681.75 | 4,425 | BKMQF66 |
| 0.01% | PEPG | PEPGEN INC | -- | $6,665.07 | 1,363 | BMTX3D7 |
| 0.01% | CDXS | CODEXIS INC | -- | $6,105.98 | 3,746 | B5LL2C2 |
| 0.01% | MRSN | MERSANA THERAPEUTICS INC | -- | $5,678.01 | 207 | BVPKH99 |
| 0.01% | NKTX | NKARTA INC | -- | $5,546.00 | 2,950 | BK80YJ8 |
| 0.01% | CLYM | CLIMB BIO INC | -- | $5,262.18 | 2,814 | BMW5LX6 |
| 0.01% | ALEC | ALECTOR INC | -- | $5,042.40 | 4,202 | BJ4LDC4 |
| 0.01% | FATE | FATE THERAPEUTICS INC | -- | $4,749.15 | 4,786 | BCZS820 |
| 0.01% | PLRX | PLIANT THERAPEUTICS INC | -- | $4,384.28 | 2,549 | BMDWW66 |
| 0.01% | MGNX | MACROGENICS INC | -- | $4,198.40 | 2,624 | BFDV8K0 |
| -- | TVGN | TEVOGEN BIO HOLDINGS INC | -- | $3,627.71 | 8,165 | BPG5P75 |
| -- | ARTV | ARTIVA BIOTHERAPEUTICS INC | -- | $3,440.85 | 1,015 | BMF1LJ7 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $3,269.15 | 3,519 | BF12XC2 |
| -- | BMEA | BIOMEA FUSION INC | -- | $3,187.59 | 2,471 | BNKF6N0 |
| -- | ACRV | ACRIVON THERAPEUTICS INC | -- | $2,703.42 | 1,306 | BP2TPK4 |
| -- | TCRX | TSCAN THERAPEUTICS INC | -- | $2,458.88 | 2,176 | BNLYBJ7 |
| -- | OKUR | ONKURE THERAPEUTICS INC-A | -- | $1,676.76 | 534 | BT7KGT6 |
| -- | APLT | APPLIED THERAPEUTICS INC | -- | $1,609.20 | 5,960 | BJL38Z1 |
| -- | QTTB | Q32 BIO INC | -- | $1,116.05 | 505 | BS2FKQ4 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 35.42% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 26,912,999 | -- | 4,905 | -- |
| 34.21% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 25,991,208 | -- | 4,737 | -- |
| 22.21% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 16,872,064 | -- | 3,075 | -- |
| 17.94% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 13,629,335 | -- | 2,484 | -- |
| 16.60% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 12,614,268 | -- | 2,299 | -- |
| 8.34% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 6,337,312 | -- | 1,155 | -- |
| -- | -- | TREASURY BILL | -- | $4,996,839.85 | 5,000,000 | BMGHP58 |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $21,253,655.65 | 21,253,656 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
Read More