BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 2/28/2026
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 6.03% | 5.70% | 60.37% | 10.56% | 62.26% | 19.25% | -0.31% | 8.72% | 16.98% | 04/07/2010 |
| BIB Market Price | 6.05% | 5.51% | 60.28% | 10.49% | 62.05% | 19.26% | -0.28% | 8.72% | 16.98% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 3/10/2026- NAV $85.11
- NAV Change $+1.23
- Market Price $85.03
- Market Price Change $+1.12
- Trading Volume (M) 12,071
- 30-Day Median Bid Ask Spread 0.25%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 3/10/2026- NAV $85.11
- NAV Change $+1.23
- Market Price $85.03
- Market Price Change $+1.12
- Trading Volume (M) 12,071
- 30-Day Median Bid Ask Spread 0.25%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 12/31/2025
Holdings
as of 3/10/2026
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 6.64% | GILD | GILEAD SCIENCES INC | -- | $5,763,830.88 | 38,798 | 2369174 |
| 6.47% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,620,155.03 | 11,259 | 2931034 |
| 6.11% | AMGN | AMGEN INC | -- | $5,306,327.62 | 14,134 | 2023607 |
| 4.12% | REGN | REGENERON PHARMACEUTICALS | -- | $3,579,903.11 | 4,637 | 2730190 |
| 2.20% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $1,912,035.78 | 5,931 | B00FWN1 |
| 1.59% | INSM | INSMED INC | -- | $1,377,219.90 | 9,574 | 2614487 |
| 1.43% | BIIB | BIOGEN INC | -- | $1,240,868.26 | 6,586 | 2455965 |
| 1.19% | UTHR | UNITED THERAPEUTICS CORP | -- | $1,035,184.92 | 1,932 | 2430412 |
| 1.12% | ARGX | ARGENX SE - ADR | -- | $970,083.74 | 1,306 | BDVLM39 |
| 1.11% | MRNA | MODERNA INC | -- | $964,294.22 | 17,539 | BGSXTS3 |
| 1.07% | ROIV | ROIVANT SCIENCES LTD | -- | $927,352.80 | 31,224 | BMW4NZ9 |
| 1.02% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $881,842.51 | 19,183 | BMVP7Y0 |
| 0.99% | RVMD | REVOLUTION MEDICINES INC | -- | $858,005.94 | 8,679 | BL71K91 |
| 0.97% | INCY | INCYTE CORP | -- | $846,224.26 | 8,813 | 2471950 |
| 0.97% | ILMN | ILLUMINA INC | -- | $839,198.65 | 6,859 | 2613990 |
| 0.84% | VTRS | VIATRIS INC | -- | $728,062.72 | 51,709 | BMWS3X9 |
| 0.76% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $663,113.64 | 2,757 | BV9G6B8 |
| 0.74% | BBIO | BRIDGEBIO PHARMA INC | -- | $642,942.32 | 8,651 | BK1KWG8 |
| 0.68% | MEDP | MEDPACE HOLDINGS INC | -- | $590,489.35 | 1,265 | BDCBC61 |
| 0.67% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $581,253.36 | 4,476 | 2623911 |
| 0.63% | IONS | IONIS PHARMACEUTICALS INC | -- | $550,123.86 | 7,271 | BDJ0LS6 |
| 0.63% | SMMT | SUMMIT THERAPEUTICS INC | -- | $545,797.59 | 33,423 | BMTVQS7 |
| 0.61% | GH | GUARDANT HEALTH INC | -- | $525,565.92 | 5,808 | BFXC911 |
| 0.60% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $525,176.25 | 8,625 | 2437071 |
| 0.60% | SNY | SANOFI-ADR | -- | $522,407.57 | 11,881 | 2964557 |
| 0.58% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $507,217.04 | 2,728 | B4Q5ZN4 |
| 0.57% | EXEL | EXELIXIS INC | -- | $497,007.73 | 12,037 | 2576941 |
| 0.51% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $440,570.04 | 1,018 | BD59BS7 |
| 0.50% | ONC | BEONE MEDICINES LTD-ADR | -- | $431,821.46 | 1,414 | BYYWPW6 |
| 0.46% | TEM | ADD | -- | $394,984.00 | 7,760 | BSLSJJ0 |
| 0.44% | BNTX | BIONTECH SE-ADR | -- | $380,776.71 | 4,539 | BK6H543 |
| 0.43% | AXSM | AXSOME THERAPEUTICS INC | -- | $376,427.42 | 2,263 | BYZR4X4 |
| 0.42% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $360,942.40 | 6,097 | BYQBFJ8 |
| 0.41% | HALO | HALOZYME THERAPEUTICS INC | -- | $358,036.80 | 5,280 | 2975098 |
| 0.41% | IBRX | IMMUNITYBIO INC | -- | $354,210.21 | 44,221 | BNSP0B8 |
| 0.41% | CYTK | CYTOKINETICS INC | -- | $352,458.00 | 5,490 | BBBSBJ5 |
| 0.40% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $348,028.93 | 1,123 | BQ721R4 |
| 0.39% | PCVX | VAXCYTE INC | -- | $342,218.24 | 5,876 | BKPVGH6 |
| 0.39% | KRYS | KRYSTAL BIOTECH INC | -- | $339,665.08 | 1,301 | BD6JX35 |
| 0.38% | NUVL | NUVALENT INC-A | -- | $331,629.18 | 3,243 | BMVBZD3 |
| 0.35% | ABVX | ABIVAX SA-ADR | -- | $305,492.00 | 2,650 | BLC89B2 |
| 0.34% | ACLX | ARCELLX INC | -- | $296,956.44 | 2,596 | BPCJ1Q2 |
| 0.32% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $278,657.96 | 2,996 | BF2YWG4 |
| 0.31% | KYMR | KYMERA THERAPEUTICS INC | -- | $273,193.40 | 3,230 | BMPRZV5 |
| 0.31% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $272,419.35 | 2,807 | BDCBCD8 |
| 0.29% | COGT | COGENT BIOSCIENCES INC | -- | $252,798.56 | 6,892 | BLR6XK8 |
| 0.28% | PTCT | PTC THERAPEUTICS INC | -- | $247,158.80 | 3,605 | B17VCN9 |
| 0.27% | CAI | CARIS LIFE SCIENCES INC | -- | $234,846.18 | 12,667 | BT18HP9 |
| 0.26% | CGON | CG ONCOLOGY INC | -- | $227,398.80 | 3,621 | BRBCSP4 |
| 0.26% | CRSP | CRISPR THERAPEUTICS AG | -- | $225,878.40 | 4,278 | BDHF4K6 |
| 0.24% | XENE | XENON PHARMACEUTICALS INC | -- | $210,316.70 | 3,470 | BRJ3GY4 |
| 0.24% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $209,775.51 | 2,307 | BJDX8Y8 |
| 0.24% | ALKS | ALKERMES PLC | -- | $205,608.88 | 7,412 | B3P6D26 |
| 0.24% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $205,092.40 | 4,580 | BFZQ0L8 |
| 0.23% | IMVT | IMMUNOVANT INC | -- | $202,416.40 | 7,870 | BJRFSB7 |
| 0.23% | FOLD | AMICUS THERAPEUTICS INC | -- | $198,929.08 | 13,853 | B19FQ48 |
| 0.23% | ERAS | ERASCA INC | -- | $198,442.46 | 12,737 | BNLYBF3 |
| 0.22% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $188,421.90 | 14,114 | BFNF1D6 |
| 0.22% | LGND | LIGAND PHARMACEUTICALS | -- | $187,452.07 | 883 | 2501578 |
| 0.22% | INDV | INDIVIOR PHARMACEUTICALS INC | -- | $186,804.02 | 5,603 | BTZRLN8 |
| 0.21% | APGE | APOGEE THERAPEUTICS INC | -- | $185,560.94 | 2,462 | BM9HHL5 |
| 0.21% | TERN | TERNS PHARMACEUTICALS INC | -- | $183,152.76 | 4,044 | BMDJ0C9 |
| 0.20% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $174,660.00 | 3,000 | BQS9486 |
| 0.20% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $171,213.84 | 7,596 | 2713317 |
| 0.19% | ADMA | ADMA BIOLOGICS INC | -- | $169,159.38 | 10,686 | B9NSBM2 |
| 0.18% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $159,164.30 | 5,090 | BP8JSP4 |
| 0.18% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $159,111.00 | 4,260 | BDD19F8 |
| 0.17% | SYRE | SPYRE THERAPEUTICS INC | -- | $144,788.31 | 3,483 | BQBBDY8 |
| 0.16% | DNLI | DENALI THERAPEUTICS INC | -- | $141,095.12 | 6,584 | BD2B4V0 |
| 0.16% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $139,262.90 | 4,753 | BKY5JZ8 |
| 0.16% | TARS | TARSUS PHARMACEUTICALS INC | -- | $139,249.14 | 1,907 | BMH5RL1 |
| 0.16% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $138,146.58 | 2,574 | B72ZBG4 |
| 0.16% | IDYA | IDEAYA BIOSCIENCES INC | -- | $136,736.64 | 3,936 | BK0VHF6 |
| 0.16% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $135,245.00 | 5,500 | BKX9VD3 |
| 0.15% | DYN | DYNE THERAPEUTICS INC | -- | $126,849.14 | 6,413 | BN15WD1 |
| 0.14% | TWST | TWIST BIOSCIENCE CORP | -- | $124,609.28 | 2,745 | BGKG6G7 |
| 0.14% | ALMS | ALUMIS INC | -- | $122,656.50 | 4,365 | BPLQG36 |
| 0.14% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $119,492.29 | 4,331 | BLB0YQ9 |
| 0.14% | BEAM | BEAM THERAPEUTICS INC | -- | $118,794.40 | 4,555 | BK6L288 |
| 0.13% | VCYT | VERACYTE INC | -- | $116,303.44 | 3,548 | BFTWZY0 |
| 0.13% | VERA | VERA THERAPEUTICS INC | -- | $115,437.00 | 2,868 | BL55460 |
| 0.13% | TVTX | TRAVERE THERAPEUTICS INC | -- | $115,006.71 | 4,017 | BLFGJD5 |
| 0.13% | IRON | DISC MEDICINE INC | -- | $112,241.28 | 1,696 | BMGJZJ8 |
| 0.13% | APLS | APELLIS PHARMACEUTICALS INC | -- | $111,496.28 | 5,677 | BYTQ6X1 |
| 0.13% | MAZE | MAZE THERAPEUTICS INC | -- | $110,278.80 | 2,160 | BSRK699 |
| 0.12% | TXG | 10X GENOMICS INC-CLASS A | -- | $106,985.34 | 5,229 | BKS3RS7 |
| 0.12% | WVE | WAVE LIFE SCIENCES LTD | -- | $103,248.75 | 7,509 | BYZG9R0 |
| 0.12% | MLYS | MINERALYS THERAPEUTICS INC | -- | $100,983.36 | 3,552 | BP9N0G0 |
| 0.11% | TNGX | TANGO THERAPEUTICS INC | -- | $99,775.50 | 6,047 | BP2P6L0 |
| 0.11% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $99,505.56 | 6,853 | BJ5FZ74 |
| 0.11% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $98,920.04 | 4,331 | BJ62Z18 |
| 0.11% | STOK | STOKE THERAPEUTICS INC | -- | $98,329.40 | 2,564 | BJQ05Z6 |
| 0.11% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $98,079.52 | 4,609 | BLB0YH0 |
| 0.11% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $95,356.56 | 2,028 | BRXB0C0 |
| 0.11% | OCUL | OCULAR THERAPEUTIX INC | -- | $94,406.55 | 9,565 | BNZB1X8 |
| 0.11% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $94,272.32 | 3,902 | BN7Q7R7 |
| 0.11% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $92,674.40 | 17,822 | BF0DMK7 |
| 0.10% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $87,616.00 | 5,920 | BFWLC09 |
| 0.10% | ZYME | ZYMEWORKS INC | -- | $85,545.60 | 3,360 | BPCQZY9 |
| 0.10% | GRAL | GRAIL INC | -- | $85,172.50 | 1,750 | BSLSSX7 |
| 0.10% | DFTX | DEFINIUM THERAPEUTICS INC | -- | $84,239.10 | 4,422 | BV2DHY6 |
| 0.10% | TYRA | TYRA BIOSCIENCES INC | -- | $83,237.04 | 2,396 | BMVNDH9 |
| 0.10% | RLAY | RELAY THERAPEUTICS INC | -- | $83,178.89 | 7,781 | BN2R582 |
| 0.10% | SRPT | SAREPTA THERAPEUTICS INC | -- | $83,072.64 | 4,704 | B8DPDT7 |
| 0.10% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $82,705.00 | 9,452 | 2100362 |
| 0.09% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $80,589.60 | 2,665 | BMFD115 |
| 0.09% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $79,412.40 | 23,085 | BM9FJ13 |
| 0.09% | NVAX | NOVAVAX INC | -- | $77,994.24 | 7,296 | BJDQXG4 |
| 0.09% | ANAB | ANAPTYSBIO INC | -- | $77,016.42 | 1,242 | BDRW1L7 |
| 0.09% | ANIP | ANI PHARMACEUTICALS INC | -- | $76,643.64 | 1,009 | BCDWBX6 |
| 0.09% | SION | SIONNA THERAPEUTICS INC | -- | $76,274.24 | 2,003 | BQKXDX4 |
| 0.09% | VCEL | VERICEL CORP | -- | $75,851.40 | 2,271 | BSBMN89 |
| 0.09% | INVA | INNOVIVA INC | -- | $75,230.37 | 3,357 | BDDXF67 |
| 0.09% | PHVS | PHARVARIS NV | -- | $74,459.64 | 2,876 | BMZ2X38 |
| 0.09% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $74,321.64 | 2,586 | BKSGZN7 |
| 0.09% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $73,984.68 | 2,618 | BCBVTX1 |
| 0.09% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $73,936.80 | 3,780 | BMX9K07 |
| 0.09% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $73,866.38 | 4,931 | BPCK358 |
| 0.08% | GMAB | GENMAB A/S -SP ADR | -- | $73,395.00 | 2,625 | BBC9WC7 |
| 0.08% | ORKA | ORUKA THERAPEUTICS INC | -- | $73,242.06 | 2,174 | BKVF0J2 |
| 0.08% | NRIX | NURIX THERAPEUTICS INC | -- | $72,345.00 | 4,550 | BMVLGP2 |
| 0.08% | NTLA | INTELLIA THERAPEUTICS INC | -- | $70,044.00 | 5,200 | BYZM6C2 |
| 0.08% | TRVI | TREVI THERAPEUTICS INC | -- | $67,702.32 | 5,757 | BJH9ZN0 |
| 0.08% | ATAI | ATAIBECKLEY INC | -- | $67,506.84 | 16,306 | BWJDYK1 |
| 0.08% | ARDX | ARDELYX INC | -- | $66,756.96 | 10,908 | BN89V40 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $65,313.06 | 1,959 | BLCD809 |
| 0.07% | NVCR | NOVOCURE LTD | -- | $64,094.25 | 5,027 | BYSS4X4 |
| 0.07% | RAPP | RAPPORT THERAPEUTICS INC | -- | $63,378.57 | 2,139 | BR3T9B6 |
| 0.07% | ZBIO | ZENAS BIOPHARMA INC | -- | $62,467.20 | 2,410 | BQB42H3 |
| 0.07% | VIR | VIR BIOTECHNOLOGY INC | -- | $61,710.48 | 6,246 | BK4PZ38 |
| 0.07% | HROW | HARROW INC | -- | $59,964.96 | 1,662 | BHNDW86 |
| 0.07% | KOD | KODIAK SCIENCES INC | -- | $59,812.02 | 2,382 | BFXC933 |
| 0.07% | MBX | MBX BIOSCIENCES INC | -- | $58,455.15 | 2,015 | BQXJKH2 |
| 0.07% | EYPT | EYEPOINT INC | -- | $57,375.04 | 3,716 | BMGS7L1 |
| 0.06% | SEPN | SEPTERNA INC | -- | $56,292.18 | 2,009 | BQNKXX2 |
| 0.06% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $56,263.34 | 3,353 | BYP80F1 |
| 0.06% | TSHA | TAYSHA GENE THERAPIES INC | -- | $56,201.86 | 12,298 | BNC1BX1 |
| 0.06% | PGEN | PRECIGEN INC | -- | $55,759.86 | 15,886 | BKM5C84 |
| 0.06% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $55,664.32 | 3,532 | BMZ4LN0 |
| 0.06% | ORIC | ORIC PHARMACEUTICALS INC | -- | $55,056.07 | 4,373 | BKVDFF7 |
| 0.06% | ALVO | ALVOTECH SA | -- | $54,529.52 | 14,054 | BPNTJ34 |
| 0.06% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $51,986.20 | 1,420 | BX7RSN3 |
| 0.06% | SVRA | SAVARA INC | -- | $51,247.35 | 9,135 | BYXGN81 |
| 0.06% | QURE | UNIQURE NV | -- | $51,073.22 | 2,797 | BJFSR88 |
| 0.06% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $50,509.44 | 2,923 | BP7KZP7 |
| 0.06% | BCAX | BICARA THERAPEUTICS INC | -- | $49,347.60 | 2,460 | BQB42F1 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $47,973.66 | 13,438 | BL53SR3 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $46,961.82 | 1,854 | BMGTLY5 |
| 0.05% | INBX | INHIBRX BIOSCIENCES INC | -- | $46,846.02 | 654 | BNSP8K3 |
| 0.05% | GERN | GERON CORP | -- | $46,712.54 | 28,658 | 2370381 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $46,395.60 | 920 | BL95N25 |
| 0.05% | GRFS | GRIFOLS SA-ADR | -- | $44,911.40 | 5,477 | B8K7T65 |
| 0.05% | GHRS | GH RESEARCH PLC | -- | $43,875.84 | 2,784 | BP6C0S2 |
| 0.05% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $43,359.00 | 7,450 | BLR7H87 |
| 0.05% | PCRX | PACIRA BIOSCIENCES INC | -- | $43,309.20 | 1,930 | B3X26D8 |
| 0.05% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $41,858.80 | 2,270 | BD06CS0 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $40,883.90 | 2,102 | BZ7PJQ1 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $40,670.85 | 8,635 | BZ0QMB7 |
| 0.05% | ARVN | ARVINAS INC | -- | $39,871.89 | 2,883 | BDZ30Q0 |
| 0.05% | CGEM | CULLINAN THERAPEUTICS INC | -- | $39,541.32 | 2,652 | BM90J52 |
| 0.05% | ANNX | ANNEXON INC | -- | $39,501.76 | 6,497 | BMVV9R5 |
| 0.05% | SANA | SANA BIOTECHNOLOGY INC | -- | $39,348.40 | 11,960 | BMFJJ97 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $39,320.68 | 4,438 | BMCR7V2 |
| 0.04% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $39,030.24 | 2,064 | BNFWZS4 |
| 0.04% | XNCR | XENCOR INC | -- | $38,407.88 | 3,206 | BGCYWN8 |
| 0.04% | JANX | JANUX THERAPEUTICS INC | -- | $38,003.07 | 2,701 | BMFX8Y7 |
| 0.04% | OMER | OMEROS CORP | -- | $37,284.64 | 3,184 | B4NB858 |
| 0.04% | FTRE | FORTREA HOLDINGS INC | -- | $37,124.60 | 4,148 | BRXYZ57 |
| 0.04% | CTMX | CYTOMX THERAPEUTICS INC | -- | $37,122.16 | 7,607 | BYWVTY5 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $36,169.56 | 3,906 | BYZD465 |
| 0.04% | MNKD | MANNKIND CORP | -- | $35,981.46 | 13,786 | BF081J4 |
| 0.04% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $35,474.23 | 3,193 | BJLKVS6 |
| 0.04% | CSTL | CASTLE BIOSCIENCES INC | -- | $34,846.00 | 1,310 | BKLCWZ3 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $34,659.48 | 2,202 | BQS7491 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $34,210.68 | 1,758 | BD9GVY0 |
| 0.04% | BIOA | BIOAGE LABS INC | -- | $33,761.70 | 1,610 | BT9K6D8 |
| 0.04% | PSNL | PERSONALIS INC | -- | $33,131.97 | 3,987 | BJQ0608 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $32,817.15 | 8,103 | BPBJFM7 |
| 0.04% | TBPH | THERAVANCE BIOPHARMA INC | -- | $31,932.28 | 2,276 | BMNDK09 |
| 0.04% | CMPS | COMPASS PATHWAYS PLC | -- | $31,478.64 | 4,231 | BMC3HS7 |
| 0.03% | REPL | REPLIMUNE GROUP INC | -- | $28,986.06 | 3,522 | BDDVW37 |
| 0.03% | ESPR | ESPERION THERAPEUTICS INC | -- | $28,976.40 | 10,732 | BBNBTD2 |
| 0.03% | SLDB | SOLID BIOSCIENCES INC | -- | $28,613.64 | 3,498 | BQHN6C7 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $28,036.88 | 3,613 | BFYQFJ2 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $27,959.68 | 2,528 | BLFBZ32 |
| 0.03% | TECX | TECTONIC THERAPEUTIC INC | -- | $27,921.60 | 840 | BPBPCG8 |
| 0.03% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $27,341.19 | 10,089 | BFZNYB7 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $27,024.80 | 7,304 | B3MZ6K5 |
| 0.03% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $25,715.60 | 4,852 | BDFKQ07 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $25,554.42 | 2,558 | BMFK3H6 |
| 0.03% | VNDA | VANDA PHARMACEUTICALS INC | -- | $25,362.68 | 2,653 | B12W3P6 |
| 0.03% | NMRA | NEUMORA THERAPEUTICS INC | -- | $24,453.26 | 7,501 | BN4JN37 |
| 0.03% | LYEL | LYELL IMMUNOPHARMA INC | -- | $24,374.13 | 951 | BTNMG41 |
| 0.03% | CRMD | CORMEDIX INC | -- | $23,775.36 | 3,538 | BJ0LT31 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $23,614.09 | 2,417 | B91XRN2 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $23,587.20 | 3,276 | BQ6C357 |
| 0.03% | KMDA | KAMADA LTD | -- | $23,206.40 | 2,590 | B2Q9833 |
| 0.03% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $23,150.16 | 814 | BQD3J33 |
| 0.03% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $23,003.40 | 5,477 | BYVQJ96 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $22,785.00 | 6,510 | BMCWKZ2 |
| 0.03% | IVVD | INVIVYD INC | -- | $22,768.86 | 12,442 | BM8NHS1 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $22,742.68 | 2,564 | BKLXFX5 |
| 0.03% | TRDA | ENTRADA THERAPEUTICS INC | -- | $22,664.40 | 1,717 | BP81RK8 |
| 0.03% | RGNX | REGENXBIO INC | -- | $22,502.70 | 2,273 | BZ0G875 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $21,586.50 | 650 | B292NQ7 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $21,559.23 | 3,843 | BMXNGZ6 |
| 0.02% | AVIR | ATEA PHARMACEUTICALS INC | -- | $21,217.35 | 3,507 | BLN9Z50 |
| 0.02% | ETON | ETON PHARMACEUTICALS INC | -- | $20,967.00 | 1,205 | BGL0JK3 |
| 0.02% | UPB | UPSTREAM BIO INC | -- | $19,691.00 | 2,425 | BRCFFK6 |
| 0.02% | FULC | FULCRUM THERAPEUTICS INC | -- | $19,456.29 | 2,429 | BJDX8Z9 |
| 0.02% | PEPG | PEPGEN INC | -- | $19,015.92 | 3,087 | BMTX3D7 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $18,611.04 | 4,011 | BYTYP72 |
| 0.02% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $18,570.35 | 13,555 | B4N8MH9 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $18,164.75 | 3,215 | 2107437 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $18,155.41 | 1,967 | BSMLR16 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $18,084.10 | 4,685 | BFY7DC4 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $18,079.20 | 1,296 | B9L5200 |
| 0.02% | ACRS | ACLARIS THERAPEUTICS INC | -- | $17,854.55 | 4,865 | BYV2W40 |
| 0.02% | ABSI | ABSCI CORP | -- | $17,150.08 | 6,752 | BN94K69 |
| 0.02% | LENZ | LENZ THERAPEUTICS INC | -- | $16,775.70 | 1,405 | BQV0J03 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $16,292.38 | 2,899 | BMVBZF5 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $16,074.00 | 2,850 | BP81R42 |
| 0.02% | NGNE | NEUROGENE INC | -- | $16,033.65 | 695 | BS2F741 |
| 0.02% | KROS | KEROS THERAPEUTICS INC | -- | $15,841.44 | 1,368 | BM7V485 |
| 0.02% | EOLS | EVOLUS INC | -- | $15,370.08 | 2,911 | BDRJH21 |
| 0.02% | NBP | NOVABRIDGE BIOSCIENCES | -- | $15,121.08 | 4,667 | BKRRKY7 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $14,409.60 | 9,006 | BFMLGR4 |
| 0.02% | CABA | CABALETTA BIO INC | -- | $14,345.72 | 4,321 | BK5MWR1 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $13,939.11 | 2,539 | BMF7DT9 |
| 0.02% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $13,906.17 | 1,037 | BPRBTY7 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $13,707.72 | 2,262 | B7F2TY6 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $13,704.32 | 4,508 | BZC0D70 |
| 0.02% | CCCC | C4 THERAPEUTICS INC | -- | $13,575.12 | 4,351 | BKX9NQ0 |
| 0.02% | VYGR | VOYAGER THERAPEUTICS INC | -- | $13,225.00 | 2,645 | BY7RB53 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $13,223.43 | 2,109 | BL5B6Z1 |
| 0.01% | OABI | OMNIAB INC | -- | $12,861.37 | 6,463 | BN13S71 |
| 0.01% | CADL | CANDEL THERAPEUTICS INC | -- | $12,596.15 | 2,465 | BP0TQC5 |
| 0.01% | VOR | VOR BIOPHARMA INC | -- | $12,096.00 | 756 | BRJJYT3 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $11,762.40 | 2,535 | BPRB2N7 |
| 0.01% | LFCR | LIFECORE BIOMEDICAL INC | -- | $11,605.80 | 1,682 | 2517058 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $11,573.76 | 4,384 | BZ8FPH3 |
| 0.01% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $11,002.80 | 2,076 | BKDQKM6 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $10,582.65 | 5,427 | BRK0149 |
| 0.01% | HUMA | HUMACYTE INC | -- | $10,424.68 | 8,407 | BMYTJP4 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $9,723.12 | 1,276 | BKC9SX3 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $9,131.20 | 8,780 | BNR5QT9 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $8,517.88 | 4,196 | BNYJR68 |
| 0.01% | MENS | JYONG BIOTECH LTD | -- | $8,327.72 | 3,413 | BPTK6Z2 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $7,697.76 | 1,392 | BP2NYN2 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $6,689.23 | 7,474 | BNNXX52 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $6,199.74 | 2,403 | BP7L561 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $5,825.40 | 4,380 | BNNXX18 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $5,808.93 | 2,559 | BKTV702 |
| 0.01% | AARD | AARDVARK THERAPEUTICS INC | -- | $5,656.83 | 977 | BTXQTX3 |
| 0.01% | GOSS | GOSSAMER BIO INC | -- | $5,269.28 | 10,391 | BJ0CK86 |
| 0.01% | CDXS | CODEXIS INC | -- | $5,028.20 | 4,055 | B5LL2C2 |
| -- | PYXS | PYXIS ONCOLOGY INC | -- | $4,332.25 | 2,795 | BLBR8D5 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $25.43 | 01 | BTFHQP5 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 36.96% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 32,082,628 | -- | 5,397 | -- |
| 29.38% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 25,507,978 | -- | 4,291 | -- |
| 26.20% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 22,743,772 | -- | 3,826 | -- |
| 18.07% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 15,687,615 | -- | 2,639 | -- |
| 17.01% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,766,213 | -- | 2,484 | -- |
| 4.33% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,762,887 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $27,729,832.19 | 27,729,832 | -- |
Index
as of 12/31/2025
- Total Number of Companies262
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$7.32 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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