BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 2/28/2026
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 6.03% | 5.70% | 60.37% | 10.56% | 62.26% | 19.25% | -0.31% | 8.72% | 16.98% | 04/07/2010 |
| BIB Market Price | 6.05% | 5.51% | 60.28% | 10.49% | 62.05% | 19.26% | -0.28% | 8.72% | 16.98% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Net Assets $81,654,969
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time
- Distributions Quarterly
- Options Available Yes
Price
as of 4/01/2026- NAV
- NAV Change
- Market Price $82.57
- Market Price Change $+1.07
- Trading Volume (M) 12,730
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Net Assets $81,654,969
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time
- Distributions Quarterly
- Options Available Yes
Price
as of 4/01/2026- NAV
- NAV Change
- Market Price $82.57
- Market Price Change $+1.07
- Trading Volume (M) 12,730
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 12/31/2025
Holdings
as of 3/31/2026
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.34% | GILD | GILEAD SCIENCES INC | -- | $4,307,229.85 | 30,905 | 2369174 |
| 5.17% | AMGN | AMGEN INC | -- | $4,172,941.00 | 11,860 | 2023607 |
| 5.13% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $4,137,193.10 | 9,265 | 2931034 |
| 4.45% | REGN | REGENERON PHARMACEUTICALS | -- | $3,590,458.08 | 4,647 | 2730190 |
| 2.43% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $1,962,720.84 | 5,932 | B00FWN1 |
| 1.95% | INSM | INSMED INC | -- | $1,576,659.84 | 9,642 | 2614487 |
| 1.49% | BIIB | BIOGEN INC | -- | $1,203,378.12 | 6,564 | 2455965 |
| 1.44% | UTHR | UNITED THERAPEUTICS CORP | -- | $1,162,240.80 | 1,960 | 2430412 |
| 1.15% | ARGX | ARGENX SE - ADR | -- | $926,687.25 | 1,269 | BDVLM39 |
| 1.14% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $919,345.05 | 19,165 | BMVP7Y0 |
| 1.11% | MRNA | MODERNA INC | -- | $897,483.60 | 17,667 | BGSXTS3 |
| 1.10% | ROIV | ROIVANT SCIENCES LTD | -- | $886,870.90 | 32,017 | BMW4NZ9 |
| 1.07% | RVMD | REVOLUTION MEDICINES INC | -- | $862,121.25 | 8,865 | BL71K91 |
| 1.04% | ILMN | ILLUMINA INC | -- | $843,221.66 | 6,841 | 2613990 |
| 1.04% | INCY | INCYTE CORP | -- | $837,856.24 | 8,902 | 2471950 |
| 0.86% | VTRS | VIATRIS INC | -- | $695,859.57 | 51,507 | BMWS3X9 |
| 0.81% | SMMT | SUMMIT THERAPEUTICS INC | -- | $657,646.56 | 34,686 | BMTVQS7 |
| 0.80% | BBIO | BRIDGEBIO PHARMA INC | -- | $644,056.98 | 8,673 | BK1KWG8 |
| 0.78% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $629,922.42 | 2,754 | BV9G6B8 |
| 0.76% | MEDP | MEDPACE HOLDINGS INC | -- | $609,361.11 | 1,269 | BDCBC61 |
| 0.73% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $591,512.60 | 4,490 | 2623911 |
| 0.69% | IONS | IONIS PHARMACEUTICALS INC | -- | $554,915.10 | 7,390 | BDJ0LS6 |
| 0.67% | GH | GUARDANT HEALTH INC | -- | $541,934.79 | 5,867 | BFXC911 |
| 0.67% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $537,603.69 | 1,027 | BD59BS7 |
| 0.65% | SNY | SANOFI-ADR | -- | $527,522.82 | 10,949 | 2964557 |
| 0.65% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $520,643.70 | 2,754 | B4Q5ZN4 |
| 0.62% | EXEL | EXELIXIS INC | -- | $498,253.13 | 11,617 | 2576941 |
| 0.60% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $486,039.96 | 8,604 | 2437071 |
| 0.56% | BNTX | BIONTECH SE-ADR | -- | $452,932.48 | 5,096 | BK6H543 |
| 0.53% | ONC | BEONE MEDICINES LTD-ADR | -- | $424,667.10 | 1,430 | BYYWPW6 |
| 0.50% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $401,126.55 | 1,245 | BQ721R4 |
| 0.49% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $392,815.50 | 6,265 | BYQBFJ8 |
| 0.48% | AXSM | AXSOME THERAPEUTICS INC | -- | $386,886.78 | 2,289 | BYZR4X4 |
| 0.46% | PCVX | VAXCYTE INC | -- | $374,112.18 | 6,438 | BKPVGH6 |
| 0.45% | CYTK | CYTOKINETICS INC | -- | $363,098.19 | 5,509 | BBBSBJ5 |
| 0.44% | IBRX | IMMUNITYBIO INC | -- | $352,750.97 | 45,991 | BNSP0B8 |
| 0.44% | TEM | TEMPUS AI INC-CL A | -- | $351,404.62 | 7,771 | BSLSJJ0 |
| 0.42% | HALO | HALOZYME THERAPEUTICS INC | -- | $341,246.40 | 5,280 | 2975098 |
| 0.42% | KRYS | KRYSTAL BIOTECH INC | -- | $338,140.88 | 1,309 | BD6JX35 |
| 0.42% | NUVL | NUVALENT INC-A | -- | $335,421.30 | 3,274 | BMVBZD3 |
| 0.38% | ABVX | ABIVAX SA-ADR | -- | $305,989.80 | 2,748 | BLC89B2 |
| 0.38% | KYMR | KYMERA THERAPEUTICS INC | -- | $304,091.79 | 3,651 | BMPRZV5 |
| 0.37% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $300,917.00 | 2,855 | BDCBCD8 |
| 0.37% | ACLX | ARCELLX INC | -- | $300,369.12 | 2,616 | BPCJ1Q2 |
| 0.35% | COGT | COGENT BIOSCIENCES INC | -- | $279,475.89 | 7,261 | BLR6XK8 |
| 0.33% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $265,693.35 | 3,055 | BF2YWG4 |
| 0.33% | ALKS | ALKERMES PLC | -- | $263,608.80 | 7,455 | B3P6D26 |
| 0.32% | CGON | CG ONCOLOGY INC | -- | $255,695.04 | 3,778 | BRBCSP4 |
| 0.31% | PTCT | PTC THERAPEUTICS INC | -- | $252,285.39 | 3,703 | B17VCN9 |
| 0.31% | TERN | TERNS PHARMACEUTICALS INC | -- | $250,789.04 | 4,757 | BMDJ0C9 |
| 0.31% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $249,333.62 | 2,699 | BJDX8Y8 |
| 0.29% | APLS | APELLIS PHARMACEUTICALS INC | -- | $230,035.14 | 5,718 | BYTQ6X1 |
| 0.28% | IMVT | IMMUNOVANT INC | -- | $226,193.04 | 9,106 | BJRFSB7 |
| 0.28% | CAI | CARIS LIFE SCIENCES INC | -- | $225,681.36 | 12,622 | BT18HP9 |
| 0.28% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $224,366.24 | 4,564 | BFZQ0L8 |
| 0.28% | ERAS | ERASCA INC | -- | $224,093.00 | 13,850 | BNLYBF3 |
| 0.27% | XENE | XENON PHARMACEUTICALS INC | -- | $216,434.30 | 3,722 | BRJ3GY4 |
| 0.26% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $212,541.72 | 5,351 | BLB0YQ9 |
| 0.26% | APGE | APOGEE THERAPEUTICS INC | -- | $206,384.84 | 2,452 | BM9HHL5 |
| 0.25% | CRSP | CRISPR THERAPEUTICS AG | -- | $204,218.01 | 4,293 | BDHF4K6 |
| 0.22% | LGND | LIGAND PHARMACEUTICALS | -- | $177,888.15 | 891 | 2501578 |
| 0.22% | SYRE | SPYRE THERAPEUTICS INC | -- | $177,195.72 | 3,513 | BQBBDY8 |
| 0.22% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $174,964.68 | 14,076 | BFNF1D6 |
| 0.21% | INDV | INDIVIOR PHARMACEUTICALS INC | -- | $170,505.12 | 5,594 | BTZRLN8 |
| 0.21% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $170,122.88 | 4,684 | BDD19F8 |
| 0.21% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $169,754.76 | 7,626 | 2713317 |
| 0.21% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $167,977.00 | 3,485 | BQS9486 |
| 0.20% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $164,595.42 | 5,142 | BP8JSP4 |
| 0.19% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $151,137.00 | 4,798 | BKY5JZ8 |
| 0.17% | DNLI | DENALI THERAPEUTICS INC | -- | $136,224.00 | 7,095 | BD2B4V0 |
| 0.17% | DYN | DYNE THERAPEUTICS INC | -- | $133,527.45 | 7,365 | BN15WD1 |
| 0.17% | TARS | TARSUS PHARMACEUTICALS INC | -- | $133,495.45 | 1,903 | BMH5RL1 |
| 0.16% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $132,584.85 | 2,565 | B72ZBG4 |
| 0.16% | IDYA | IDEAYA BIOSCIENCES INC | -- | $130,914.28 | 3,929 | BK0VHF6 |
| 0.16% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $130,616.64 | 5,544 | BKX9VD3 |
| 0.16% | TWST | TWIST BIOSCIENCE CORP | -- | $130,299.84 | 2,742 | BGKG6G7 |
| 0.16% | VERA | VERA THERAPEUTICS INC | -- | $128,414.16 | 3,192 | BL55460 |
| 0.16% | TNGX | TANGO THERAPEUTICS INC | -- | $126,043.00 | 6,025 | BP2P6L0 |
| 0.15% | ALMS | ALUMIS INC | -- | $124,579.65 | 5,655 | BPLQG36 |
| 0.15% | TVTX | TRAVERE THERAPEUTICS INC | -- | $122,613.17 | 4,127 | BLFGJD5 |
| 0.14% | VCYT | VERACYTE INC | -- | $114,506.55 | 3,555 | BFTWZY0 |
| 0.14% | TXG | 10X GENOMICS INC-CLASS A | -- | $111,754.72 | 5,264 | BKS3RS7 |
| 0.14% | IRON | DISC MEDICINE INC | -- | $109,145.58 | 1,707 | BMGJZJ8 |
| 0.13% | BEAM | BEAM THERAPEUTICS INC | -- | $108,593.31 | 4,557 | BK6L288 |
| 0.13% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $106,814.40 | 11,220 | 2100362 |
| 0.13% | ORKA | ORUKA THERAPEUTICS INC | -- | $106,193.25 | 2,165 | BKVF0J2 |
| 0.13% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $104,115.20 | 2,656 | BMFD115 |
| 0.13% | KOD | KODIAK SCIENCES INC | -- | $104,067.60 | 2,730 | BFXC933 |
| 0.13% | SRPT | SAREPTA THERAPEUTICS INC | -- | $102,010.88 | 4,688 | B8DPDT7 |
| 0.12% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $99,074.24 | 4,621 | BLB0YH0 |
| 0.12% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $98,851.95 | 2,053 | BRXB0C0 |
| 0.12% | ADMA | ADMA BIOLOGICS INC | -- | $95,992.54 | 10,654 | B9NSBM2 |
| 0.12% | MLYS | MINERALYS THERAPEUTICS INC | -- | $95,898.60 | 3,540 | BP9N0G0 |
| 0.12% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $95,605.44 | 6,888 | BJ5FZ74 |
| 0.11% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $92,155.20 | 3,945 | BN7Q7R7 |
| 0.11% | TYRA | TYRA BIOSCIENCES INC | -- | $91,422.10 | 2,387 | BMVNDH9 |
| 0.11% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $90,566.85 | 4,323 | BJ62Z18 |
| 0.11% | GRAL | GRAIL INC | -- | $90,078.24 | 1,743 | BSLSSX7 |
| 0.11% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $88,668.43 | 2,621 | BCBVTX1 |
| 0.11% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $88,149.36 | 5,948 | BFWLC09 |
| 0.10% | DFTX | DEFINIUM THERAPEUTICS INC | -- | $84,294.00 | 4,460 | BV2DHY6 |
| 0.10% | ZYME | ZYMEWORKS INC | -- | $83,833.92 | 3,348 | BPCQZY9 |
| 0.10% | STOK | STOKE THERAPEUTICS INC | -- | $83,190.80 | 2,555 | BJQ05Z6 |
| 0.10% | OCUL | OCULAR THERAPEUTIX INC | -- | $82,489.33 | 9,739 | BNZB1X8 |
| 0.10% | PHVS | PHARVARIS NV | -- | $80,964.50 | 2,866 | BMZ2X38 |
| 0.10% | SION | SIONNA THERAPEUTICS INC | -- | $80,059.73 | 1,997 | BQKXDX4 |
| 0.10% | RLAY | RELAY THERAPEUTICS INC | -- | $79,550.25 | 7,995 | BN2R582 |
| 0.10% | GMAB | GENMAB A/S -SP ADR | -- | $77,243.57 | 2,879 | BBC9WC7 |
| 0.10% | INVA | INNOVIVA INC | -- | $77,192.90 | 3,313 | BDDXF67 |
| 0.10% | ANIP | ANI PHARMACEUTICALS INC | -- | $77,130.70 | 1,003 | BCDWBX6 |
| 0.09% | VCEL | VERICEL CORP | -- | $73,058.07 | 2,271 | BSBMN89 |
| 0.09% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $72,489.88 | 2,588 | BKSGZN7 |
| 0.09% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $71,681.43 | 23,349 | BM9FJ13 |
| 0.09% | NRIX | NURIX THERAPEUTICS INC | -- | $71,300.00 | 4,600 | BMVLGP2 |
| 0.09% | ANAB | ANAPTYSBIO INC | -- | $68,770.40 | 1,240 | BDRW1L7 |
| 0.08% | TRVI | TREVI THERAPEUTICS INC | -- | $68,430.48 | 5,736 | BJH9ZN0 |
| 0.08% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $68,307.84 | 3,776 | BMX9K07 |
| 0.08% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $68,290.70 | 4,913 | BPCK358 |
| 0.08% | NTLA | INTELLIA THERAPEUTICS INC | -- | $67,740.88 | 5,284 | BYZM6C2 |
| 0.08% | RAPP | RAPPORT THERAPEUTICS INC | -- | $66,710.28 | 2,132 | BR3T9B6 |
| 0.08% | ARDX | ARDELYX INC | -- | $65,710.30 | 10,970 | BN89V40 |
| 0.08% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $64,682.28 | 18,428 | BF0DMK7 |
| 0.08% | MAZE | MAZE THERAPEUTICS INC | -- | $64,267.05 | 2,153 | BSRK699 |
| 0.08% | VIR | VIR BIOTECHNOLOGY INC | -- | $62,997.76 | 7,031 | BK4PZ38 |
| 0.08% | PGEN | PRECIGEN INC | -- | $61,254.36 | 15,828 | BKM5C84 |
| 0.08% | WVE | WAVE LIFE SCIENCES LTD | -- | $61,052.25 | 8,421 | BYZG9R0 |
| 0.07% | MBX | MBX BIOSCIENCES INC | -- | $59,968.65 | 2,009 | BQXJKH2 |
| 0.07% | NVAX | NOVAVAX INC | -- | $59,324.32 | 7,288 | BJDQXG4 |
| 0.07% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $59,124.15 | 1,961 | BLCD809 |
| 0.07% | HROW | HARROW INC | -- | $58,461.08 | 1,658 | BHNDW86 |
| 0.07% | ATAI | ATAIBECKLEY INC | -- | $57,517.92 | 16,248 | BWJDYK1 |
| 0.07% | ORIC | ORIC PHARMACEUTICALS INC | -- | $56,888.30 | 4,490 | BKVDFF7 |
| 0.07% | BCAX | BICARA THERAPEUTICS INC | -- | $56,368.26 | 2,834 | BQB42F1 |
| 0.07% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $56,110.95 | 3,411 | BP7KZP7 |
| 0.07% | NVCR | NOVOCURE LTD | -- | $55,481.00 | 5,090 | BYSS4X4 |
| 0.07% | TSHA | TAYSHA GENE THERAPIES INC | -- | $54,770.91 | 12,253 | BNC1BX1 |
| 0.07% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $54,043.22 | 3,694 | BYP80F1 |
| 0.07% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $53,452.35 | 3,585 | BMZ4LN0 |
| 0.06% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $51,051.13 | 923 | BL95N25 |
| 0.06% | ALVO | ALVOTECH SA | -- | $50,681.68 | 14,776 | BPNTJ34 |
| 0.06% | SVRA | SAVARA INC | -- | $49,702.38 | 9,103 | BYXGN81 |
| 0.06% | SEPN | SEPTERNA INC | -- | $48,132.09 | 2,003 | BQNKXX2 |
| 0.06% | EYPT | EYEPOINT INC | -- | $47,744.56 | 3,704 | BMGS7L1 |
| 0.06% | ZBIO | ZENAS BIOPHARMA INC | -- | $47,604.25 | 2,435 | BQB42H3 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $47,331.38 | 13,562 | BL53SR3 |
| 0.06% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $46,992.47 | 1,421 | BX7RSN3 |
| 0.06% | QURE | UNIQURE NV | -- | $45,567.45 | 2,787 | BJFSR88 |
| 0.06% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $45,513.93 | 2,261 | BD06CS0 |
| 0.05% | INBX | INHIBRX BIOSCIENCES INC | -- | $43,766.73 | 651 | BNSP8K3 |
| 0.05% | GRFS | GRIFOLS SA-ADR | -- | $43,765.14 | 5,457 | B8K7T65 |
| 0.05% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $43,047.60 | 7,422 | BLR7H87 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $42,610.29 | 1,847 | BMGTLY5 |
| 0.05% | GERN | GERON CORP | -- | $42,548.44 | 28,556 | 2370381 |
| 0.05% | PCRX | PACIRA BIOSCIENCES INC | -- | $40,906.00 | 1,810 | B3X26D8 |
| 0.05% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $39,748.11 | 2,029 | BNFWZS4 |
| 0.05% | XNCR | XENCOR INC | -- | $39,568.86 | 3,281 | BGCYWN8 |
| 0.05% | FTRE | FORTREA HOLDINGS INC | -- | $39,403.86 | 4,183 | BRXYZ57 |
| 0.05% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $39,151.64 | 3,524 | BJLKVS6 |
| 0.05% | GHRS | GH RESEARCH PLC | -- | $39,016.50 | 2,775 | BP6C0S2 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $38,718.00 | 8,604 | BZ0QMB7 |
| 0.05% | JANX | JANUX THERAPEUTICS INC | -- | $37,835.80 | 2,722 | BMFX8Y7 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $37,632.14 | 2,093 | BZ7PJQ1 |
| 0.05% | CGEM | CULLINAN THERAPEUTICS INC | -- | $37,557.03 | 2,643 | BM90J52 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $36,793.41 | 2,267 | BMNDK09 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $36,019.96 | 2,342 | BQS7491 |
| 0.04% | ANNX | ANNEXON INC | -- | $35,871.50 | 6,475 | BMVV9R5 |
| 0.04% | CTMX | CYTOMX THERAPEUTICS INC | -- | $35,621.30 | 7,579 | BYWVTY5 |
| 0.04% | SPRY | ARS PHARMACEUTICALS INC | -- | $35,516.69 | 4,423 | BMCR7V2 |
| 0.04% | SANA | SANA BIOTECHNOLOGY INC | -- | $34,318.08 | 11,916 | BMFJJ97 |
| 0.04% | BIOA | BIOAGE LABS INC | -- | $34,000.56 | 1,944 | BT9K6D8 |
| 0.04% | MNKD | MANNKIND CORP | -- | $33,768.35 | 13,783 | BF081J4 |
| 0.04% | OMER | OMEROS CORP | -- | $33,485.76 | 3,171 | B4NB858 |
| 0.04% | VOR | VOR BIOPHARMA INC | -- | $33,146.72 | 1,858 | BRJJYT3 |
| 0.04% | CSTL | CASTLE BIOSCIENCES INC | -- | $32,651.50 | 1,330 | BKLCWZ3 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $31,641.96 | 3,892 | BYZD465 |
| 0.04% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $31,176.00 | 3,600 | BFYQFJ2 |
| 0.04% | ARVN | ARVINAS INC | -- | $30,337.20 | 2,862 | BDZ30Q0 |
| 0.04% | PSNL | PERSONALIS INC | -- | $29,817.97 | 4,681 | BJQ0608 |
| 0.04% | ETON | ETON PHARMACEUTICALS INC | -- | $29,591.32 | 1,199 | BGL0JK3 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $29,301.56 | 10,694 | BBNBTD2 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $28,835.73 | 1,533 | BD9GVY0 |
| 0.04% | REPL | REPLIMUNE GROUP INC | -- | $28,259.10 | 3,694 | BDDVW37 |
| 0.03% | PRME | PRIME MEDICINE INC | -- | $28,101.00 | 8,075 | BPBJFM7 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $27,110.72 | 2,548 | BMFK3H6 |
| 0.03% | TECX | TECTONIC THERAPEUTIC INC | -- | $25,964.40 | 840 | BPBPCG8 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $25,559.82 | 7,282 | B3MZ6K5 |
| 0.03% | SLDB | SOLID BIOSCIENCES INC | -- | $25,099.20 | 3,486 | BQHN6C7 |
| 0.03% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $24,529.32 | 10,053 | BFZNYB7 |
| 0.03% | CRMD | CORMEDIX INC | -- | $23,927.96 | 3,524 | BJ0LT31 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $23,458.44 | 2,517 | BLFBZ32 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $23,405.76 | 2,408 | B91XRN2 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $23,336.60 | 4,220 | BMC3HS7 |
| 0.03% | FULC | FULCRUM THERAPEUTICS INC | -- | $22,848.93 | 2,979 | BJDX8Z9 |
| 0.03% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $22,650.70 | 5,458 | BYVQJ96 |
| 0.03% | KYTX | KYVERNA THERAPEUTICS INC | -- | $22,058.28 | 2,556 | BSMLR16 |
| 0.03% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $21,983.52 | 813 | BQD3J33 |
| 0.03% | LRMR | LARIMAR THERAPEUTICS INC | -- | $21,856.50 | 4,857 | BMXNGZ6 |
| 0.03% | UPB | UPSTREAM BIO INC | -- | $21,762.00 | 2,418 | BRCFFK6 |
| 0.03% | TRDA | ENTRADA THERAPEUTICS INC | -- | $21,618.06 | 1,713 | BP81RK8 |
| 0.03% | KMDA | KAMADA LTD | -- | $21,525.54 | 2,581 | B2Q9833 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $21,245.42 | 2,282 | BKLXFX5 |
| 0.03% | ACRS | ACLARIS THERAPEUTICS INC | -- | $20,231.25 | 5,395 | BYV2W40 |
| 0.03% | ABSI | ABSCI CORP | -- | $20,178.00 | 6,726 | BN94K69 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $19,920.00 | 664 | B292NQ7 |
| 0.02% | LYEL | LYELL IMMUNOPHARMA INC | -- | $19,077.06 | 951 | BTNMG41 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $19,006.29 | 2,841 | BP81R42 |
| 0.02% | RGNX | REGENXBIO INC | -- | $18,972.32 | 2,264 | BZ0G875 |
| 0.02% | AVIR | ATEA PHARMACEUTICALS INC | -- | $18,803.10 | 3,495 | BLN9Z50 |
| 0.02% | LXEO | LEXEO THERAPEUTICS INC | -- | $18,741.10 | 3,265 | BQ6C357 |
| 0.02% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $18,533.67 | 6,549 | BMCWKZ2 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $18,339.14 | 2,654 | B12W3P6 |
| 0.02% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $17,831.88 | 13,509 | B4N8MH9 |
| 0.02% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $17,787.72 | 1,362 | BPRBTY7 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $17,391.64 | 4,858 | BDFKQ07 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $17,254.16 | 5,602 | BFY7DC4 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $17,141.40 | 3,204 | 2107437 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $16,406.37 | 1,299 | B9L5200 |
| 0.02% | IVVD | INVIVYD INC | -- | $16,114.80 | 12,396 | BM8NHS1 |
| 0.02% | CADL | CANDEL THERAPEUTICS INC | -- | $16,023.00 | 3,270 | BP0TQC5 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $15,124.90 | 2,870 | BMVBZF5 |
| 0.02% | KROS | KEROS THERAPEUTICS INC | -- | $15,047.52 | 1,363 | BM7V485 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $14,576.25 | 7,475 | BN4JN37 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $14,543.64 | 2,276 | B7F2TY6 |
| 0.02% | NGNE | NEUROGENE INC | -- | $13,950.72 | 692 | BS2F741 |
| 0.02% | LENZ | LENZ THERAPEUTICS INC | -- | $12,800.85 | 1,399 | BQV0J03 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $12,728.22 | 4,146 | BYTYP72 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $12,523.60 | 2,620 | BMF7DT9 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $12,382.74 | 8,973 | BFMLGR4 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $12,377.75 | 4,501 | BZC0D70 |
| 0.02% | NBP | NOVABRIDGE BIOSCIENCES | -- | $12,351.66 | 5,021 | BKRRKY7 |
| 0.01% | EOLS | EVOLUS INC | -- | $11,914.89 | 2,899 | BDRJH21 |
| 0.01% | CABA | CABALETTA BIO INC | -- | $11,583.14 | 4,306 | BK5MWR1 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $11,477.32 | 4,364 | BKX9NQ0 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $11,301.03 | 6,687 | BRK0149 |
| 0.01% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $11,067.00 | 2,100 | BL5B6Z1 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $10,784.02 | 4,366 | BZ8FPH3 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $10,731.25 | 2,525 | BPRB2N7 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $10,178.82 | 2,637 | BY7RB53 |
| 0.01% | OABI | OMNIAB INC | -- | $10,109.23 | 6,439 | BN13S71 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $9,812.12 | 1,271 | BKC9SX3 |
| 0.01% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $9,618.72 | 2,073 | BKDQKM6 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $7,943.90 | 4,181 | BNYJR68 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $7,241.85 | 1,386 | BP2NYN2 |
| 0.01% | MENS | JYONG BIOTECH LTD | -- | $7,138.00 | 3,320 | BPTK6Z2 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $6,918.66 | 2,394 | BP7L561 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $6,766.31 | 8,742 | BNR5QT9 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $6,713.51 | 9,696 | BNNXX52 |
| 0.01% | CDXS | CODEXIS INC | -- | $6,586.83 | 4,041 | B5LL2C2 |
| 0.01% | LFCR | LIFECORE BIOMEDICAL INC | -- | $6,231.00 | 1,675 | 2517058 |
| 0.01% | PEPG | PEPGEN INC | -- | $5,444.52 | 3,076 | BMTX3D7 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $5,429.37 | 2,549 | BKTV702 |
| 0.01% | HUMA | HUMACYTE INC | -- | $5,237.64 | 8,633 | BMYTJP4 |
| 0.01% | PYXS | PYXIS ONCOLOGY INC | -- | $4,067.56 | 2,786 | BLBR8D5 |
| -- | AARD | AARDVARK THERAPEUTICS INC | -- | $3,668.21 | 973 | BTXQTX3 |
| -- | GOSS | GOSSAMER BIO INC | -- | $3,401.29 | 10,354 | BJ0CK86 |
| -- | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $3,205.93 | 4,363 | BNNXX18 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $24.91 | 01 | BTFHQP5 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 34.76% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 28,052,478 | -- | 4,804 | -- |
| 30.99% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 25,010,150 | -- | 4,283 | -- |
| 26.79% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 21,617,459 | -- | 3,702 | -- |
| 19.09% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 15,410,177 | -- | 2,639 | -- |
| 14.40% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 11,620,406 | -- | 1,990 | -- |
| 4.58% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,696,340 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $25,062,940.27 | 25,062,940 | -- |
Index
as of 12/31/2025
- Total Number of Companies262
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$7.32 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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