BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 12/31/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 2/05/2026- NAV $81.75
- NAV Change $-3.52
- Market Price $81.74
- Market Price Change $-3.50
- Trading Volume (M) 22,451
- 30-Day Median Bid Ask Spread 0.28%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 2/05/2026- NAV $81.75
- NAV Change $-3.52
- Market Price $81.74
- Market Price Change $-3.50
- Trading Volume (M) 22,451
- 30-Day Median Bid Ask Spread 0.28%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 12/31/2025
Holdings
as of 2/05/2026
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 7.04% | GILD | GILEAD SCIENCES INC | -- | $6,043,958.31 | 40,463 | 2369174 |
| 6.32% | AMGN | AMGEN INC | -- | $5,421,004.20 | 14,739 | 2023607 |
| 6.28% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,387,805.83 | 11,743 | 2931034 |
| 4.32% | REGN | REGENERON PHARMACEUTICALS | -- | $3,707,422.68 | 4,836 | 2730190 |
| 2.39% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,049,050.64 | 6,186 | B00FWN1 |
| 1.76% | INSM | INSMED INC | -- | $1,508,185.58 | 9,986 | 2614487 |
| 1.48% | BIIB | BIOGEN INC | -- | $1,273,237.84 | 6,869 | 2455965 |
| 1.30% | ARGX | ARGENX SE - ADR | -- | $1,118,082.53 | 1,363 | BDVLM39 |
| 1.12% | UTHR | UNITED THERAPEUTICS CORP | -- | $965,522.88 | 2,016 | 2430412 |
| 1.11% | ILMN | ILLUMINA INC | -- | $955,845.94 | 7,154 | 2613990 |
| 1.10% | INCY | INCYTE CORP | -- | $944,569.92 | 9,192 | 2471950 |
| 1.03% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $882,220.50 | 20,005 | BMVP7Y0 |
| 1.01% | RVMD | REVOLUTION MEDICINES INC | -- | $870,349.80 | 9,052 | BL71K91 |
| 0.90% | VTRS | VIATRIS INC | -- | $773,327.52 | 53,928 | BMWS3X9 |
| 0.87% | MRNA | MODERNA INC | -- | $747,594.04 | 18,292 | BGSXTS3 |
| 0.83% | MEDP | MEDPACE HOLDINGS INC | -- | $713,935.13 | 1,319 | BDCBC61 |
| 0.80% | ROIV | ROIVANT SCIENCES LTD | -- | $688,402.96 | 32,564 | BMW4NZ9 |
| 0.75% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $643,857.24 | 4,668 | 2623911 |
| 0.74% | IONS | IONIS PHARMACEUTICALS INC | -- | $633,112.32 | 7,584 | BDJ0LS6 |
| 0.73% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $624,967.50 | 2,875 | BV9G6B8 |
| 0.69% | GH | GUARDANT HEALTH INC | -- | $595,864.88 | 6,058 | BFXC911 |
| 0.69% | SNY | SANOFI-ADR | -- | $588,401.10 | 12,390 | 2964557 |
| 0.67% | BBIO | BRIDGEBIO PHARMA INC | -- | $574,972.06 | 9,022 | BK1KWG8 |
| 0.62% | EXEL | EXELIXIS INC | -- | $531,912.98 | 12,554 | 2576941 |
| 0.60% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $514,064.25 | 8,995 | 2437071 |
| 0.60% | RNA | AVIDITY BIOSCIENCES INC | -- | $513,745.10 | 7,055 | BMWHPY1 |
| 0.60% | ONC | BEONE MEDICINES LTD-ADR | -- | $511,478.00 | 1,474 | BYYWPW6 |
| 0.58% | BNTX | BIONTECH SE-ADR | -- | $499,626.36 | 4,734 | BK6H543 |
| 0.57% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $492,615.46 | 1,063 | BD59BS7 |
| 0.56% | SMMT | SUMMIT THERAPEUTICS INC | -- | $482,755.60 | 34,856 | BMTVQS7 |
| 0.54% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $464,161.75 | 2,845 | B4Q5ZN4 |
| 0.50% | HALO | HALOZYME THERAPEUTICS INC | -- | $431,780.52 | 5,506 | 2975098 |
| 0.50% | AXSM | AXSOME THERAPEUTICS INC | -- | $426,782.40 | 2,360 | BYZR4X4 |
| 0.49% | TEM | TEMPUS AI INC | -- | $424,449.36 | 8,094 | BSLSJJ0 |
| 0.48% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $411,045.76 | 6,359 | BYQBFJ8 |
| 0.42% | KRYS | KRYSTAL BIOTECH INC | -- | $363,455.12 | 1,358 | BD6JX35 |
| 0.42% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $357,881.02 | 1,171 | BQ721R4 |
| 0.40% | CYTK | CYTOKINETICS INC | -- | $344,874.00 | 5,725 | BBBSBJ5 |
| 0.40% | NUVL | NUVALENT INC-A | -- | $341,243.80 | 3,382 | BMVBZD3 |
| 0.38% | PCVX | VAXCYTE INC | -- | $330,414.39 | 6,129 | BKPVGH6 |
| 0.38% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $324,593.75 | 3,125 | BF2YWG4 |
| 0.36% | ABVX | ABIVAX SA-ADR | -- | $306,002.44 | 2,764 | BLC89B2 |
| 0.33% | CAI | CARIS LIFE SCIENCES INC | -- | $280,733.75 | 13,211 | BT18HP9 |
| 0.32% | PTCT | PTC THERAPEUTICS INC | -- | $272,001.24 | 3,759 | B17VCN9 |
| 0.30% | IBRX | IMMUNITYBIO INC | -- | $260,105.52 | 46,118 | BNSP0B8 |
| 0.30% | ALKS | ALKERMES PLC | -- | $259,375.05 | 7,731 | B3P6D26 |
| 0.30% | COGT | COGENT BIOSCIENCES INC | -- | $256,575.90 | 7,187 | BLR6XK8 |
| 0.30% | KYMR | KYMERA THERAPEUTICS INC | -- | $255,841.86 | 3,369 | BMPRZV5 |
| 0.28% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $236,341.38 | 2,406 | BJDX8Y8 |
| 0.28% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $236,121.09 | 2,927 | BDCBCD8 |
| 0.27% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $229,074.09 | 3,129 | BQS9486 |
| 0.25% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $217,399.63 | 14,719 | BFNF1D6 |
| 0.25% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $212,293.20 | 4,776 | BFZQ0L8 |
| 0.24% | FOLD | AMICUS THERAPEUTICS INC | -- | $206,288.88 | 14,446 | B19FQ48 |
| 0.24% | CRSP | CRISPR THERAPEUTICS AG | -- | $204,716.56 | 4,462 | BDHF4K6 |
| 0.23% | INDV | INDIVIOR PHARMACEUTICALS INC | -- | $201,325.80 | 5,844 | BTZRLN8 |
| 0.23% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $199,001.97 | 4,443 | BDD19F8 |
| 0.23% | IMVT | IMMUNOVANT INC | -- | $197,460.42 | 8,207 | BJRFSB7 |
| 0.22% | CGON | CG ONCOLOGY INC | -- | $185,828.40 | 3,777 | BRBCSP4 |
| 0.22% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $185,826.66 | 7,921 | 2713317 |
| 0.21% | ACLX | ARCELLX INC | -- | $181,206.58 | 2,707 | BPCJ1Q2 |
| 0.21% | ADMA | ADMA BIOLOGICS INC | -- | $177,635.36 | 11,144 | B9NSBM2 |
| 0.21% | LGND | LIGAND PHARMACEUTICALS | -- | $176,738.18 | 922 | 2501578 |
| 0.20% | GRAL | GRAIL INC | -- | $171,659.50 | 1,825 | BSLSSX7 |
| 0.20% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $170,206.54 | 5,309 | BP8JSP4 |
| 0.19% | APGE | APOGEE THERAPEUTICS INC | -- | $159,487.71 | 2,567 | BM9HHL5 |
| 0.18% | ERAS | ERASCA INC | -- | $157,813.92 | 13,284 | BNLYBF3 |
| 0.17% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $149,511.45 | 5,735 | BKX9VD3 |
| 0.17% | TERN | TERNS PHARMACEUTICALS INC | -- | $149,064.12 | 4,218 | BMDJ0C9 |
| 0.17% | XENE | XENON PHARMACEUTICALS INC | -- | $146,131.02 | 3,618 | BRJ3GY4 |
| 0.16% | IRON | DISC MEDICINE INC | -- | $138,487.44 | 1,768 | BMGJZJ8 |
| 0.16% | DNLI | DENALI THERAPEUTICS INC | -- | $137,477.34 | 6,867 | BD2B4V0 |
| 0.16% | TWST | TWIST BIOSCIENCE CORP | -- | $134,847.30 | 2,863 | BGKG6G7 |
| 0.16% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $134,780.83 | 4,957 | BKY5JZ8 |
| 0.16% | APLS | APELLIS PHARMACEUTICALS INC | -- | $133,577.76 | 5,921 | BYTQ6X1 |
| 0.15% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $132,558.45 | 2,685 | B72ZBG4 |
| 0.15% | IDYA | IDEAYA BIOSCIENCES INC | -- | $130,415.85 | 4,105 | BK0VHF6 |
| 0.15% | VCYT | VERACYTE INC | -- | $129,016.86 | 3,701 | BFTWZY0 |
| 0.14% | TVTX | TRAVERE THERAPEUTICS INC | -- | $123,449.83 | 4,189 | BLFGJD5 |
| 0.14% | TARS | TARSUS PHARMACEUTICALS INC | -- | $123,236.12 | 1,988 | BMH5RL1 |
| 0.14% | VERA | VERA THERAPEUTICS INC | -- | $122,481.45 | 2,991 | BL55460 |
| 0.14% | ALMS | ALUMIS INC | -- | $119,899.68 | 4,552 | BPLQG36 |
| 0.14% | SYRE | SPYRE THERAPEUTICS INC | -- | $119,671.02 | 3,633 | BQBBDY8 |
| 0.14% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $117,727.56 | 7,148 | BJ5FZ74 |
| 0.14% | BEAM | BEAM THERAPEUTICS INC | -- | $117,492.23 | 4,751 | BK6L288 |
| 0.13% | DYN | DYNE THERAPEUTICS INC | -- | $110,669.85 | 6,687 | BN15WD1 |
| 0.13% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $107,459.43 | 4,517 | BJ62Z18 |
| 0.12% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $106,330.18 | 4,517 | BLB0YQ9 |
| 0.12% | MLYS | MINERALYS THERAPEUTICS INC | -- | $104,518.05 | 3,705 | BP9N0G0 |
| 0.12% | WVE | WAVE LIFE SCIENCES LTD | -- | $99,845.25 | 7,831 | BYZG9R0 |
| 0.12% | MAZE | MAZE THERAPEUTICS INC | -- | $99,019.35 | 2,253 | BSRK699 |
| 0.11% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $98,197.77 | 2,697 | BKSGZN7 |
| 0.11% | TXG | 10X GENOMICS INC-CLASS A | -- | $96,535.80 | 5,454 | BKS3RS7 |
| 0.11% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $92,111.83 | 3,683 | BMZ4LN0 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $90,056.70 | 2,115 | BRXB0C0 |
| 0.10% | OCUL | OCULAR THERAPEUTIX INC | -- | $88,877.25 | 9,975 | BNZB1X8 |
| 0.10% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $88,026.98 | 6,173 | BFWLC09 |
| 0.10% | ANIP | ANI PHARMACEUTICALS INC | -- | $85,738.00 | 1,052 | BCDWBX6 |
| 0.10% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $85,707.00 | 24,075 | BM9FJ13 |
| 0.10% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $85,164.02 | 5,498 | BRJZSK0 |
| 0.10% | GMAB | GENMAB A/S -SP ADR | -- | $84,764.89 | 2,737 | BBC9WC7 |
| 0.10% | VCEL | VERICEL CORP | -- | $83,779.84 | 2,368 | BSBMN89 |
| 0.10% | SRPT | SAREPTA THERAPEUTICS INC | -- | $83,549.18 | 4,906 | B8DPDT7 |
| 0.10% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $82,010.50 | 4,070 | BN7Q7R7 |
| 0.09% | STOK | STOKE THERAPEUTICS INC | -- | $81,534.00 | 2,675 | BJQ05Z6 |
| 0.09% | HROW | HARROW INC | -- | $79,868.04 | 1,734 | BHNDW86 |
| 0.09% | ARDX | ARDELYX INC | -- | $79,639.00 | 11,377 | BN89V40 |
| 0.09% | MNKD | MANNKIND CORP | -- | $79,222.78 | 14,378 | BF081J4 |
| 0.09% | ZYME | ZYMEWORKS INC | -- | $77,158.08 | 3,504 | BPCQZY9 |
| 0.09% | MBX | MBX BIOSCIENCES INC | -- | $75,777.10 | 2,102 | BQXJKH2 |
| 0.09% | NRIX | NURIX THERAPEUTICS INC | -- | $75,698.70 | 4,746 | BMVLGP2 |
| 0.09% | INVA | INNOVIVA INC | -- | $75,516.57 | 3,501 | BDDXF67 |
| 0.09% | PHVS | PHARVARIS NV | -- | $75,394.86 | 2,999 | BMZ2X38 |
| 0.09% | TNGX | TANGO THERAPEUTICS INC | -- | $75,356.70 | 6,306 | BP2P6L0 |
| 0.09% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $75,005.21 | 2,779 | BMFD115 |
| 0.09% | DFTX | DEFINIUM THERAPEUTICS INC | -- | $74,945.00 | 4,612 | BV2DHY6 |
| 0.09% | RAPT | RAPT THERAPEUTICS INC | -- | $74,810.96 | 1,297 | BTJZB49 |
| 0.09% | SION | SIONNA THERAPEUTICS INC | -- | $73,672.50 | 2,090 | BQKXDX4 |
| 0.09% | TYRA | TYRA BIOSCIENCES INC | -- | $73,620.54 | 2,499 | BMVNDH9 |
| 0.09% | ALVO | ALVOTECH SA | -- | $73,133.44 | 14,656 | BPNTJ34 |
| 0.08% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $72,536.10 | 2,730 | BCBVTX1 |
| 0.08% | QURE | UNIQURE NV | -- | $71,524.84 | 2,917 | BJFSR88 |
| 0.08% | ORKA | ORUKA THERAPEUTICS INC | -- | $71,229.14 | 2,267 | BKVF0J2 |
| 0.08% | PGEN | PRECIGEN INC | -- | $70,244.08 | 16,567 | BKM5C84 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $69,441.60 | 1,480 | BX7RSN3 |
| 0.08% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $66,794.58 | 5,142 | BPCK358 |
| 0.08% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $66,652.82 | 3,497 | BYP80F1 |
| 0.08% | RLAY | RELAY THERAPEUTICS INC | -- | $66,137.25 | 8,115 | BN2R582 |
| 0.08% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $65,831.40 | 3,942 | BMX9K07 |
| 0.08% | UPB | UPSTREAM BIO INC | -- | $65,780.00 | 2,530 | BRCFFK6 |
| 0.08% | TRVI | TREVI THERAPEUTICS INC | -- | $65,683.76 | 6,004 | BJH9ZN0 |
| 0.07% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $63,169.56 | 2,043 | BLCD809 |
| 0.07% | ANAB | ANAPTYSBIO INC | -- | $62,078.40 | 1,296 | BDRW1L7 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $61,611.76 | 2,152 | BNFWZS4 |
| 0.07% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $61,513.92 | 9,858 | 2100362 |
| 0.07% | NTLA | INTELLIA THERAPEUTICS INC | -- | $60,141.07 | 5,423 | BYZM6C2 |
| 0.07% | NVAX | NOVAVAX INC | -- | $59,882.83 | 7,609 | BJDQXG4 |
| 0.07% | FTRE | FORTREA HOLDINGS INC | -- | $59,698.80 | 4,326 | BRXYZ57 |
| 0.07% | ATAI | ATAIBECKLEY INC | -- | $57,987.05 | 17,005 | BWJDYK1 |
| 0.07% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $57,626.10 | 3,049 | BP7KZP7 |
| 0.07% | RAPP | RAPPORT THERAPEUTICS INC | -- | $57,027.60 | 2,232 | BR3T9B6 |
| 0.07% | TSHA | TAYSHA GENE THERAPIES INC | -- | $56,558.25 | 12,825 | BNC1BX1 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $55,521.93 | 681 | BNSP8K3 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $53,683.79 | 7,769 | BLR7H87 |
| 0.06% | NVCR | NOVOCURE LTD | -- | $52,901.87 | 5,243 | BYSS4X4 |
| 0.06% | ZBIO | ZENAS BIOPHARMA INC | -- | $52,798.13 | 2,513 | BQB42H3 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $52,493.28 | 5,712 | B8K7T65 |
| 0.06% | KOD | KODIAK SCIENCES INC | -- | $52,188.84 | 2,484 | BFXC933 |
| 0.06% | SEPN | SEPTERNA INC | -- | $51,226.24 | 2,096 | BQNKXX2 |
| 0.06% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $50,377.36 | 4,807 | BLB0YH0 |
| 0.06% | EYPT | EYEPOINT INC | -- | $49,341.48 | 3,876 | BMGS7L1 |
| 0.06% | SVRA | SAVARA INC | -- | $49,159.32 | 9,527 | BYXGN81 |
| 0.06% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $47,950.00 | 959 | BL95N25 |
| 0.05% | VTYX | VENTYX BIOSCIENCES INC | -- | $46,573.54 | 3,341 | BMG99Y1 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $46,463.34 | 2,373 | BMNDK09 |
| 0.05% | ORIC | ORIC PHARMACEUTICALS INC | -- | $45,417.60 | 4,560 | BKVDFF7 |
| 0.05% | VIR | VIR BIOTECHNOLOGY INC | -- | $45,076.88 | 6,514 | BK4PZ38 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $44,979.84 | 2,192 | BZ7PJQ1 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $44,752.76 | 4,628 | BMCR7V2 |
| 0.05% | CSTL | CASTLE BIOSCIENCES INC | -- | $44,290.80 | 1,367 | BKLCWZ3 |
| 0.05% | SANA | SANA BIOTECHNOLOGY INC | -- | $44,275.60 | 12,472 | BMFJJ97 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $43,865.32 | 18,587 | BF0DMK7 |
| 0.05% | GERN | GERON CORP | -- | $43,637.94 | 29,889 | 2370381 |
| 0.05% | CTMX | CYTOMX THERAPEUTICS INC | -- | $41,568.92 | 7,933 | BYWVTY5 |
| 0.05% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $41,337.71 | 3,331 | BJLKVS6 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $41,269.55 | 1,933 | BMGTLY5 |
| 0.05% | PCRX | PACIRA BIOSCIENCES INC | -- | $41,005.04 | 2,014 | B3X26D8 |
| 0.05% | GHRS | GH RESEARCH PLC | -- | $39,668.64 | 2,904 | BP6C0S2 |
| 0.05% | ARVN | ARVINAS INC | -- | $38,970.72 | 3,007 | BDZ30Q0 |
| 0.05% | ABCL | ABCELLERA BIOLOGICS INC | -- | $38,961.70 | 14,015 | BL53SR3 |
| 0.05% | BCAX | BICARA THERAPEUTICS INC | -- | $38,731.50 | 2,565 | BQB42F1 |
| 0.04% | ANNX | ANNEXON INC | -- | $38,154.51 | 6,777 | BMVV9R5 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $36,919.68 | 2,296 | BQS7491 |
| 0.04% | XNCR | XENCOR INC | -- | $36,182.08 | 3,344 | BGCYWN8 |
| 0.04% | OMER | OMEROS CORP | -- | $35,656.80 | 3,320 | B4NB858 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $35,593.74 | 11,193 | BBNBTD2 |
| 0.04% | JANX | JANUX THERAPEUTICS INC | -- | $34,298.88 | 2,816 | BMFX8Y7 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $34,084.80 | 2,367 | BD06CS0 |
| 0.04% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $33,895.65 | 7,617 | B3MZ6K5 |
| 0.04% | BIOA | BIOAGE LABS INC | -- | $33,546.42 | 1,679 | BT9K6D8 |
| 0.04% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $33,048.35 | 9,005 | BZ0QMB7 |
| 0.04% | CGEM | CULLINAN THERAPEUTICS INC | -- | $32,777.10 | 2,766 | BM90J52 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $31,124.34 | 1,833 | BD9GVY0 |
| 0.04% | PSNL | PERSONALIS INC | -- | $30,831.57 | 4,158 | BJQ0608 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $30,147.60 | 4,074 | BYZD465 |
| 0.03% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $28,237.00 | 850 | BQD3J33 |
| 0.03% | PRME | PRIME MEDICINE INC | -- | $27,384.48 | 8,452 | BPBJFM7 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $27,136.80 | 3,769 | BFYQFJ2 |
| 0.03% | CRMD | CORMEDIX INC | -- | $27,114.15 | 3,689 | BJ0LT31 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $26,536.65 | 2,667 | BMFK3H6 |
| 0.03% | GOSS | GOSSAMER BIO INC | -- | $26,388.10 | 10,837 | BJ0CK86 |
| 0.03% | REPL | REPLIMUNE GROUP INC | -- | $25,453.89 | 3,673 | BDDVW37 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $25,192.52 | 4,412 | BMC3HS7 |
| 0.03% | KROS | KEROS THERAPEUTICS INC | -- | $24,584.24 | 1,426 | BM7V485 |
| 0.03% | RGNX | REGENXBIO INC | -- | $24,316.20 | 2,370 | BZ0G875 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $24,243.24 | 14,136 | B4N8MH9 |
| 0.03% | FULC | FULCRUM THERAPEUTICS INC | -- | $24,199.70 | 2,534 | BJDX8Z9 |
| 0.03% | ALT | ALTIMMUNE INC | -- | $24,039.12 | 4,886 | BFY7DC4 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $23,543.13 | 3,417 | BQ6C357 |
| 0.03% | SLDB | SOLID BIOSCIENCES INC | -- | $22,727.04 | 3,648 | BQHN6C7 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $22,598.26 | 677 | B292NQ7 |
| 0.03% | LYEL | LYELL IMMUNOPHARMA INC | -- | $22,481.52 | 993 | BTNMG41 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $22,443.25 | 2,675 | BKLXFX5 |
| 0.03% | IVVD | INVIVYD INC | -- | $22,187.25 | 12,975 | BM8NHS1 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $22,036.96 | 2,636 | BLFBZ32 |
| 0.03% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $21,934.08 | 5,712 | BYVQJ96 |
| 0.03% | SIGA | SIGA TECHNOLOGIES INC | -- | $21,828.03 | 3,353 | 2107437 |
| 0.03% | KMDA | KAMADA LTD | -- | $21,662.02 | 2,701 | B2Q9833 |
| 0.02% | PRTA | PROTHENA CORP PLC | -- | $21,042.00 | 2,520 | B91XRN2 |
| 0.02% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $20,981.10 | 6,790 | BMCWKZ2 |
| 0.02% | LENZ | LENZ THERAPEUTICS INC | -- | $20,466.05 | 1,465 | BQV0J03 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $20,025.36 | 876 | BPBPCG8 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $20,005.41 | 2,767 | B12W3P6 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $18,025.30 | 1,790 | BP81RK8 |
| 0.02% | ETON | ETON PHARMACEUTICALS INC | -- | $18,023.60 | 1,256 | BGL0JK3 |
| 0.02% | ABSI | ABSCI CORP | -- | $17,813.73 | 7,041 | BN94K69 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $17,522.47 | 1,351 | B9L5200 |
| 0.02% | ACRS | ACLARIS THERAPEUTICS INC | -- | $17,197.47 | 5,073 | BYV2W40 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $17,150.86 | 10,522 | BFZNYB7 |
| 0.02% | NBP | NOVABRIDGE BIOSCIENCES | -- | $16,210.44 | 4,868 | BKRRKY7 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $16,017.61 | 2,359 | B7F2TY6 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $15,937.23 | 4,183 | BYTYP72 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $15,935.28 | 2,973 | BP81R42 |
| 0.02% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $15,667.36 | 1,082 | BPRBTY7 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $15,333.08 | 7,823 | BN4JN37 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $15,180.00 | 5,060 | BDFKQ07 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $14,910.77 | 2,051 | BSMLR16 |
| 0.02% | AVIR | ATEA PHARMACEUTICALS INC | -- | $14,705.16 | 3,658 | BLN9Z50 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $13,914.96 | 4,701 | BZC0D70 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $13,849.04 | 2,648 | BMF7DT9 |
| 0.02% | PEPG | PEPGEN INC | -- | $13,809.51 | 3,219 | BMTX3D7 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $13,663.96 | 3,023 | BMVBZF5 |
| 0.02% | CADL | CANDEL THERAPEUTICS INC | -- | $13,595.30 | 2,570 | BP0TQC5 |
| 0.02% | EOLS | EVOLUS INC | -- | $13,384.35 | 3,035 | BDRJH21 |
| 0.02% | LFCR | LIFECORE BIOMEDICAL INC | -- | $13,260.24 | 1,754 | 2517058 |
| 0.01% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $12,397.44 | 9,392 | BFMLGR4 |
| 0.01% | LRMR | LARIMAR THERAPEUTICS INC | -- | $12,304.56 | 4,008 | BMXNGZ6 |
| 0.01% | NGNE | NEUROGENE INC | -- | $11,868.25 | 725 | BS2F741 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $11,827.31 | 5,659 | BRK0149 |
| 0.01% | AARD | AARDVARK THERAPEUTICS INC | -- | $11,504.51 | 1,019 | BTXQTX3 |
| 0.01% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $11,501.46 | 2,166 | BKDQKM6 |
| 0.01% | OABI | OMNIAB INC | -- | $11,121.00 | 6,740 | BN13S71 |
| 0.01% | CABA | CABALETTA BIO INC | -- | $10,501.31 | 4,507 | BK5MWR1 |
| 0.01% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $9,939.48 | 2,199 | BL5B6Z1 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $9,809.24 | 2,644 | BPRB2N7 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $9,766.86 | 2,759 | BY7RB53 |
| 0.01% | VOR | VOR BIOPHARMA INC | -- | $9,523.23 | 789 | BRJJYT3 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $9,336.60 | 1,330 | BKC9SX3 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $8,534.31 | 9,156 | BNR5QT9 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $7,898.88 | 1,452 | BP2NYN2 |
| 0.01% | HUMA | HUMACYTE INC | -- | $7,770.20 | 8,768 | BMYTJP4 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $7,759.98 | 4,538 | BKX9NQ0 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $7,610.72 | 4,571 | BZ8FPH3 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $6,476.48 | 4,376 | BNYJR68 |
| 0.01% | MENS | JYONG BIOTECH LTD | -- | $5,909.60 | 3,560 | BPTK6Z2 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $5,847.00 | 7,796 | BNNXX52 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $5,763.80 | 2,506 | BP7L561 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $5,762.88 | 2,668 | BKTV702 |
| 0.01% | CDXS | CODEXIS INC | -- | $5,370.83 | 4,229 | B5LL2C2 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $5,023.70 | 4,567 | BNNXX18 |
| 0.01% | PYXS | PYXIS ONCOLOGY INC | -- | $4,489.10 | 2,915 | BLBR8D5 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $14.60 | 01 | BTFHQP5 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| 36.26% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 31,120,053 | -- | 5,360 | -- |
| 29.86% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 25,633,402 | -- | 4,415 | -- |
| 23.97% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 20,570,587 | -- | 3,543 | -- |
| 17.85% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 15,321,981 | -- | 2,639 | -- |
| 16.80% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,422,054 | -- | 2,484 | -- |
| 4.28% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,675,185 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $24,955,526.26 | 24,955,526 | -- |
Index
as of 12/31/2025
- Total Number of Companies262
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$7.32 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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