BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 2/28/2026
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 6.03% | 5.70% | 60.37% | 10.56% | 62.26% | 19.25% | -0.31% | 8.72% | 16.98% | 04/07/2010 |
| BIB Market Price | 6.05% | 5.51% | 60.28% | 10.49% | 62.05% | 19.26% | -0.28% | 8.72% | 16.98% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 3/12/2026- NAV $79.43
- NAV Change $-4.54
- Market Price $79.42
- Market Price Change $-4.55
- Trading Volume (M) 18,716
- 30-Day Median Bid Ask Spread 0.25%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 3/12/2026- NAV $79.43
- NAV Change $-4.54
- Market Price $79.42
- Market Price Change $-4.55
- Trading Volume (M) 18,716
- 30-Day Median Bid Ask Spread 0.25%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 12/31/2025
Holdings
as of 3/12/2026
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 6.91% | GILD | GILEAD SCIENCES INC | -- | $5,602,043.22 | 38,798 | 2369174 |
| 6.64% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,383,265.67 | 11,259 | 2931034 |
| 6.42% | AMGN | AMGEN INC | -- | $5,198,343.86 | 14,134 | 2023607 |
| 4.27% | REGN | REGENERON PHARMACEUTICALS | -- | $3,462,030.57 | 4,637 | 2730190 |
| 2.32% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $1,881,491.13 | 5,931 | B00FWN1 |
| 1.65% | INSM | INSMED INC | -- | $1,335,764.48 | 9,574 | 2614487 |
| 1.50% | BIIB | BIOGEN INC | -- | $1,217,751.40 | 6,586 | 2455965 |
| 1.27% | UTHR | UNITED THERAPEUTICS CORP | -- | $1,029,408.24 | 1,932 | 2430412 |
| 1.16% | MRNA | MODERNA INC | -- | $936,407.21 | 17,539 | BGSXTS3 |
| 1.14% | ARGX | ARGENX SE - ADR | -- | $925,758.10 | 1,306 | BDVLM39 |
| 1.10% | ROIV | ROIVANT SCIENCES LTD | -- | $891,445.20 | 31,224 | BMW4NZ9 |
| 1.09% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $879,924.21 | 19,183 | BMVP7Y0 |
| 1.02% | RVMD | REVOLUTION MEDICINES INC | -- | $825,112.53 | 8,679 | BL71K91 |
| 1.00% | INCY | INCYTE CORP | -- | $811,060.39 | 8,813 | 2471950 |
| 0.98% | ILMN | ILLUMINA INC | -- | $792,626.04 | 6,859 | 2613990 |
| 0.88% | VTRS | VIATRIS INC | -- | $713,584.20 | 51,709 | BMWS3X9 |
| 0.78% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $631,380.57 | 2,757 | BV9G6B8 |
| 0.73% | BBIO | BRIDGEBIO PHARMA INC | -- | $588,094.98 | 8,651 | BK1KWG8 |
| 0.71% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $571,943.28 | 4,476 | 2623911 |
| 0.69% | MEDP | MEDPACE HOLDINGS INC | -- | $561,470.25 | 1,265 | BDCBC61 |
| 0.65% | IONS | IONIS PHARMACEUTICALS INC | -- | $525,984.14 | 7,271 | BDJ0LS6 |
| 0.64% | SNY | SANOFI-ADR | -- | $518,368.03 | 11,881 | 2964557 |
| 0.64% | SMMT | SUMMIT THERAPEUTICS INC | -- | $516,719.58 | 33,423 | BMTVQS7 |
| 0.63% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $509,478.75 | 8,625 | 2437071 |
| 0.61% | EXEL | EXELIXIS INC | -- | $495,563.29 | 12,037 | 2576941 |
| 0.61% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $491,912.96 | 2,728 | B4Q5ZN4 |
| 0.60% | GH | GUARDANT HEALTH INC | -- | $487,988.16 | 5,808 | BFXC911 |
| 0.55% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $446,627.14 | 1,018 | BD59BS7 |
| 0.50% | BNTX | BIONTECH SE-ADR | -- | $408,963.90 | 4,539 | BK6H543 |
| 0.50% | ONC | BEONE MEDICINES LTD-ADR | -- | $403,414.20 | 1,414 | BYYWPW6 |
| 0.47% | TEM | TEMPUS AI INC-CL A | -- | $384,352.80 | 7,760 | BSLSJJ0 |
| 0.43% | AXSM | AXSOME THERAPEUTICS INC | -- | $348,773.56 | 2,263 | BYZR4X4 |
| 0.43% | IBRX | IMMUNITYBIO INC | -- | $345,808.22 | 44,221 | BNSP0B8 |
| 0.42% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $340,684.51 | 1,123 | BQ721R4 |
| 0.41% | HALO | HALOZYME THERAPEUTICS INC | -- | $335,596.80 | 5,280 | 2975098 |
| 0.41% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $335,395.97 | 6,097 | BYQBFJ8 |
| 0.41% | PCVX | VAXCYTE INC | -- | $330,289.96 | 5,876 | BKPVGH6 |
| 0.41% | CYTK | CYTOKINETICS INC | -- | $329,400.00 | 5,490 | BBBSBJ5 |
| 0.40% | KRYS | KRYSTAL BIOTECH INC | -- | $326,954.31 | 1,301 | BD6JX35 |
| 0.39% | NUVL | NUVALENT INC-A | -- | $317,814.00 | 3,243 | BMVBZD3 |
| 0.38% | ABVX | ABIVAX SA-ADR | -- | $309,997.00 | 2,650 | BLC89B2 |
| 0.37% | ACLX | ARCELLX INC | -- | $296,696.84 | 2,596 | BPCJ1Q2 |
| 0.34% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $273,085.40 | 2,996 | BF2YWG4 |
| 0.33% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $267,843.94 | 2,807 | BDCBCD8 |
| 0.31% | KYMR | KYMERA THERAPEUTICS INC | -- | $250,325.00 | 3,230 | BMPRZV5 |
| 0.30% | COGT | COGENT BIOSCIENCES INC | -- | $243,494.36 | 6,892 | BLR6XK8 |
| 0.28% | PTCT | PTC THERAPEUTICS INC | -- | $228,412.80 | 3,605 | B17VCN9 |
| 0.28% | CGON | CG ONCOLOGY INC | -- | $228,014.37 | 3,621 | BRBCSP4 |
| 0.28% | CAI | CARIS LIFE SCIENCES INC | -- | $224,079.23 | 12,667 | BT18HP9 |
| 0.26% | CRSP | CRISPR THERAPEUTICS AG | -- | $209,065.86 | 4,278 | BDHF4K6 |
| 0.26% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $207,122.46 | 2,307 | BJDX8Y8 |
| 0.25% | ALKS | ALKERMES PLC | -- | $204,867.68 | 7,412 | B3P6D26 |
| 0.25% | XENE | XENON PHARMACEUTICALS INC | -- | $200,913.00 | 3,470 | BRJ3GY4 |
| 0.25% | FOLD | AMICUS THERAPEUTICS INC | -- | $199,067.61 | 13,853 | B19FQ48 |
| 0.24% | IMVT | IMMUNOVANT INC | -- | $196,671.30 | 7,870 | BJRFSB7 |
| 0.24% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $191,444.00 | 4,580 | BFZQ0L8 |
| 0.23% | LGND | LIGAND PHARMACEUTICALS | -- | $186,736.84 | 883 | 2501578 |
| 0.23% | ERAS | ERASCA INC | -- | $186,597.05 | 12,737 | BNLYBF3 |
| 0.22% | APGE | APOGEE THERAPEUTICS INC | -- | $180,981.62 | 2,462 | BM9HHL5 |
| 0.22% | TERN | TERNS PHARMACEUTICALS INC | -- | $178,906.56 | 4,044 | BMDJ0C9 |
| 0.21% | INDV | INDIVIOR PHARMACEUTICALS INC | -- | $172,908.58 | 5,603 | BTZRLN8 |
| 0.21% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $170,991.11 | 14,114 | BFNF1D6 |
| 0.20% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $163,740.00 | 3,000 | BQS9486 |
| 0.20% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $161,566.92 | 7,596 | 2713317 |
| 0.20% | ADMA | ADMA BIOLOGICS INC | -- | $160,183.14 | 10,686 | B9NSBM2 |
| 0.19% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $155,532.60 | 4,260 | BDD19F8 |
| 0.19% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $151,783.80 | 5,090 | BP8JSP4 |
| 0.18% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $142,304.82 | 4,753 | BKY5JZ8 |
| 0.17% | SYRE | SPYRE THERAPEUTICS INC | -- | $140,748.03 | 3,483 | BQBBDY8 |
| 0.17% | DNLI | DENALI THERAPEUTICS INC | -- | $136,288.80 | 6,584 | BD2B4V0 |
| 0.16% | TARS | TARSUS PHARMACEUTICALS INC | -- | $130,000.19 | 1,907 | BMH5RL1 |
| 0.16% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $129,884.04 | 2,574 | B72ZBG4 |
| 0.16% | IDYA | IDEAYA BIOSCIENCES INC | -- | $129,218.88 | 3,936 | BK0VHF6 |
| 0.16% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $126,005.00 | 5,500 | BKX9VD3 |
| 0.15% | TWST | TWIST BIOSCIENCE CORP | -- | $118,089.90 | 2,745 | BGKG6G7 |
| 0.15% | VERA | VERA THERAPEUTICS INC | -- | $118,075.56 | 2,868 | BL55460 |
| 0.15% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $117,889.82 | 4,331 | BLB0YQ9 |
| 0.14% | BEAM | BEAM THERAPEUTICS INC | -- | $116,562.45 | 4,555 | BK6L288 |
| 0.14% | DYN | DYNE THERAPEUTICS INC | -- | $115,818.78 | 6,413 | BN15WD1 |
| 0.14% | MAZE | MAZE THERAPEUTICS INC | -- | $111,963.60 | 2,160 | BSRK699 |
| 0.14% | TVTX | TRAVERE THERAPEUTICS INC | -- | $110,668.35 | 4,017 | BLFGJD5 |
| 0.14% | VCYT | VERACYTE INC | -- | $109,739.64 | 3,548 | BFTWZY0 |
| 0.13% | ALMS | ALUMIS INC | -- | $109,255.95 | 4,365 | BPLQG36 |
| 0.13% | APLS | APELLIS PHARMACEUTICALS INC | -- | $104,400.03 | 5,677 | BYTQ6X1 |
| 0.13% | TNGX | TANGO THERAPEUTICS INC | -- | $103,706.05 | 6,047 | BP2P6L0 |
| 0.13% | IRON | DISC MEDICINE INC | -- | $101,352.96 | 1,696 | BMGJZJ8 |
| 0.12% | WVE | WAVE LIFE SCIENCES LTD | -- | $100,245.15 | 7,509 | BYZG9R0 |
| 0.12% | TXG | 10X GENOMICS INC-CLASS A | -- | $99,037.26 | 5,229 | BKS3RS7 |
| 0.12% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $98,033.43 | 4,609 | BLB0YH0 |
| 0.12% | MLYS | MINERALYS THERAPEUTICS INC | -- | $95,868.48 | 3,552 | BP9N0G0 |
| 0.12% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $94,026.01 | 4,331 | BJ62Z18 |
| 0.12% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $93,608.98 | 3,902 | BN7Q7R7 |
| 0.12% | STOK | STOKE THERAPEUTICS INC | -- | $93,534.72 | 2,564 | BJQ05Z6 |
| 0.12% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $93,429.96 | 2,028 | BRXB0C0 |
| 0.11% | TYRA | TYRA BIOSCIENCES INC | -- | $86,256.00 | 2,396 | BMVNDH9 |
| 0.11% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $85,319.85 | 6,853 | BJ5FZ74 |
| 0.10% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $85,070.40 | 5,920 | BFWLC09 |
| 0.10% | OCUL | OCULAR THERAPEUTIX INC | -- | $84,841.55 | 9,565 | BNZB1X8 |
| 0.10% | RLAY | RELAY THERAPEUTICS INC | -- | $82,089.55 | 7,781 | BN2R582 |
| 0.10% | SRPT | SAREPTA THERAPEUTICS INC | -- | $80,156.16 | 4,704 | B8DPDT7 |
| 0.10% | DFTX | DEFINIUM THERAPEUTICS INC | -- | $79,507.56 | 4,422 | BV2DHY6 |
| 0.10% | ANAB | ANAPTYSBIO INC | -- | $79,227.18 | 1,242 | BDRW1L7 |
| 0.10% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $79,207.76 | 9,452 | 2100362 |
| 0.10% | ZYME | ZYMEWORKS INC | -- | $78,052.80 | 3,360 | BPCQZY9 |
| 0.10% | GRAL | GRAIL INC | -- | $77,595.00 | 1,750 | BSLSSX7 |
| 0.09% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $76,778.65 | 2,665 | BMFD115 |
| 0.09% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $75,949.65 | 23,085 | BM9FJ13 |
| 0.09% | PHVS | PHARVARIS NV | -- | $75,868.88 | 2,876 | BMZ2X38 |
| 0.09% | NVAX | NOVAVAX INC | -- | $75,148.80 | 7,296 | BJDQXG4 |
| 0.09% | INVA | INNOVIVA INC | -- | $73,753.29 | 3,357 | BDDXF67 |
| 0.09% | SION | SIONNA THERAPEUTICS INC | -- | $73,470.04 | 2,003 | BQKXDX4 |
| 0.09% | ANIP | ANI PHARMACEUTICALS INC | -- | $73,142.41 | 1,009 | BCDWBX6 |
| 0.09% | VCEL | VERICEL CORP | -- | $72,921.81 | 2,271 | BSBMN89 |
| 0.09% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $72,535.54 | 17,822 | BF0DMK7 |
| 0.09% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $72,230.62 | 2,618 | BCBVTX1 |
| 0.09% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $72,009.00 | 3,780 | BMX9K07 |
| 0.09% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $71,864.94 | 2,586 | BKSGZN7 |
| 0.09% | NRIX | NURIX THERAPEUTICS INC | -- | $71,025.50 | 4,550 | BMVLGP2 |
| 0.09% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $70,907.78 | 4,931 | BPCK358 |
| 0.09% | GMAB | GENMAB A/S -SP ADR | -- | $69,746.25 | 2,625 | BBC9WC7 |
| 0.09% | ORKA | ORUKA THERAPEUTICS INC | -- | $69,546.26 | 2,174 | BKVF0J2 |
| 0.08% | NTLA | INTELLIA THERAPEUTICS INC | -- | $66,820.00 | 5,200 | BYZM6C2 |
| 0.08% | TRVI | TREVI THERAPEUTICS INC | -- | $64,478.40 | 5,757 | BJH9ZN0 |
| 0.08% | ATAI | ATAIBECKLEY INC | -- | $62,288.92 | 16,306 | BWJDYK1 |
| 0.08% | ARDX | ARDELYX INC | -- | $61,739.28 | 10,908 | BN89V40 |
| 0.08% | RAPP | RAPPORT THERAPEUTICS INC | -- | $61,325.13 | 2,139 | BR3T9B6 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $60,807.36 | 1,959 | BLCD809 |
| 0.07% | NVCR | NOVOCURE LTD | -- | $60,374.27 | 5,027 | BYSS4X4 |
| 0.07% | VIR | VIR BIOTECHNOLOGY INC | -- | $59,212.08 | 6,246 | BK4PZ38 |
| 0.07% | HROW | HARROW INC | -- | $59,100.72 | 1,662 | BHNDW86 |
| 0.07% | ZBIO | ZENAS BIOPHARMA INC | -- | $59,045.00 | 2,410 | BQB42H3 |
| 0.07% | TSHA | TAYSHA GENE THERAPIES INC | -- | $56,693.78 | 12,298 | BNC1BX1 |
| 0.07% | KOD | KODIAK SCIENCES INC | -- | $56,667.78 | 2,382 | BFXC933 |
| 0.07% | MBX | MBX BIOSCIENCES INC | -- | $56,319.25 | 2,015 | BQXJKH2 |
| 0.07% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $53,681.53 | 3,353 | BYP80F1 |
| 0.07% | SEPN | SEPTERNA INC | -- | $53,128.01 | 2,009 | BQNKXX2 |
| 0.06% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $52,662.12 | 3,532 | BMZ4LN0 |
| 0.06% | EYPT | EYEPOINT INC | -- | $52,135.48 | 3,716 | BMGS7L1 |
| 0.06% | PGEN | PRECIGEN INC | -- | $52,106.08 | 15,886 | BKM5C84 |
| 0.06% | ORIC | ORIC PHARMACEUTICALS INC | -- | $51,426.48 | 4,373 | BKVDFF7 |
| 0.06% | ALVO | ALVOTECH SA | -- | $49,751.16 | 14,054 | BPNTJ34 |
| 0.06% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $49,700.00 | 1,420 | BX7RSN3 |
| 0.06% | SVRA | SAVARA INC | -- | $48,598.20 | 9,135 | BYXGN81 |
| 0.06% | QURE | UNIQURE NV | -- | $47,381.18 | 2,797 | BJFSR88 |
| 0.06% | BCAX | BICARA THERAPEUTICS INC | -- | $47,256.60 | 2,460 | BQB42F1 |
| 0.06% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $46,884.92 | 2,923 | BP7KZP7 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $46,629.86 | 13,438 | BL53SR3 |
| 0.06% | GERN | GERON CORP | -- | $45,852.80 | 28,658 | 2370381 |
| 0.06% | PCRX | PACIRA BIOSCIENCES INC | -- | $45,412.90 | 1,930 | B3X26D8 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $45,322.20 | 654 | BNSP8K3 |
| 0.06% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $45,080.00 | 920 | BL95N25 |
| 0.06% | AVBP | ARRIVENT BIOPHARMA INC | -- | $44,672.13 | 1,854 | BMGTLY5 |
| 0.05% | GRFS | GRIFOLS SA-ADR | -- | $43,651.69 | 5,477 | B8K7T65 |
| 0.05% | GHRS | GH RESEARCH PLC | -- | $43,207.68 | 2,784 | BP6C0S2 |
| 0.05% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $40,826.00 | 7,450 | BLR7H87 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $39,496.58 | 2,102 | BZ7PJQ1 |
| 0.05% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $39,452.60 | 2,270 | BD06CS0 |
| 0.05% | MNKD | MANNKIND CORP | -- | $38,876.52 | 13,786 | BF081J4 |
| 0.05% | JANX | JANUX THERAPEUTICS INC | -- | $37,665.45 | 2,701 | BMFX8Y7 |
| 0.05% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $37,513.20 | 2,064 | BNFWZS4 |
| 0.05% | FTRE | FORTREA HOLDINGS INC | -- | $37,497.92 | 4,148 | BRXYZ57 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $37,303.20 | 8,635 | BZ0QMB7 |
| 0.05% | XNCR | XENCOR INC | -- | $37,221.66 | 3,206 | BGCYWN8 |
| 0.05% | CTMX | CYTOMX THERAPEUTICS INC | -- | $37,046.09 | 7,607 | BYWVTY5 |
| 0.05% | CGEM | CULLINAN THERAPEUTICS INC | -- | $36,995.40 | 2,652 | BM90J52 |
| 0.05% | SANA | SANA BIOTECHNOLOGY INC | -- | $36,956.40 | 11,960 | BMFJJ97 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $36,569.12 | 4,438 | BMCR7V2 |
| 0.04% | OMER | OMEROS CORP | -- | $36,361.28 | 3,184 | B4NB858 |
| 0.04% | ARVN | ARVINAS INC | -- | $35,979.84 | 2,883 | BDZ30Q0 |
| 0.04% | ANNX | ANNEXON INC | -- | $35,343.68 | 6,497 | BMVV9R5 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $34,529.04 | 3,906 | BYZD465 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $33,184.14 | 2,202 | BQS7491 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $33,173.46 | 1,758 | BD9GVY0 |
| 0.04% | CSTL | CASTLE BIOSCIENCES INC | -- | $33,169.20 | 1,310 | BKLCWZ3 |
| 0.04% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $32,632.46 | 3,193 | BJLKVS6 |
| 0.04% | BIOA | BIOAGE LABS INC | -- | $32,014.85 | 1,610 | BT9K6D8 |
| 0.04% | TBPH | THERAVANCE BIOPHARMA INC | -- | $31,613.64 | 2,276 | BMNDK09 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $30,224.19 | 8,103 | BPBJFM7 |
| 0.04% | TECX | TECTONIC THERAPEUTIC INC | -- | $28,660.80 | 840 | BPBPCG8 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $28,051.53 | 4,231 | BMC3HS7 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $27,603.32 | 3,613 | BFYQFJ2 |
| 0.03% | SLDB | SOLID BIOSCIENCES INC | -- | $26,969.58 | 3,498 | BQHN6C7 |
| 0.03% | REPL | REPLIMUNE GROUP INC | -- | $26,696.76 | 3,522 | BDDVW37 |
| 0.03% | ESPR | ESPERION THERAPEUTICS INC | -- | $26,508.04 | 10,732 | BBNBTD2 |
| 0.03% | PSNL | PERSONALIS INC | -- | $26,274.33 | 3,987 | BJQ0608 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $25,747.68 | 2,528 | BLFBZ32 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $25,631.16 | 2,558 | BMFK3H6 |
| 0.03% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $24,919.83 | 10,089 | BFZNYB7 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $24,687.52 | 7,304 | B3MZ6K5 |
| 0.03% | VNDA | VANDA PHARMACEUTICALS INC | -- | $24,646.37 | 2,653 | B12W3P6 |
| 0.03% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $23,871.84 | 4,852 | BDFKQ07 |
| 0.03% | LYEL | LYELL IMMUNOPHARMA INC | -- | $23,561.03 | 951 | BTNMG41 |
| 0.03% | NMRA | NEUMORA THERAPEUTICS INC | -- | $23,553.14 | 7,501 | BN4JN37 |
| 0.03% | ETON | ETON PHARMACEUTICALS INC | -- | $22,919.10 | 1,205 | BGL0JK3 |
| 0.03% | UPB | UPSTREAM BIO INC | -- | $22,879.88 | 2,425 | BRCFFK6 |
| 0.03% | CRMD | CORMEDIX INC | -- | $22,643.20 | 3,538 | BJ0LT31 |
| 0.03% | KMDA | KAMADA LTD | -- | $22,507.10 | 2,590 | B2Q9833 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $22,502.27 | 2,417 | B91XRN2 |
| 0.03% | IVVD | INVIVYD INC | -- | $22,395.60 | 12,442 | BM8NHS1 |
| 0.03% | TRDA | ENTRADA THERAPEUTICS INC | -- | $22,286.66 | 1,717 | BP81RK8 |
| 0.03% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $22,072.31 | 5,477 | BYVQJ96 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $21,719.88 | 3,276 | BQ6C357 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $21,665.80 | 2,564 | BKLXFX5 |
| 0.03% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $21,652.40 | 814 | BQD3J33 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $21,417.90 | 6,510 | BMCWKZ2 |
| 0.03% | AVIR | ATEA PHARMACEUTICALS INC | -- | $21,392.70 | 3,507 | BLN9Z50 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $20,754.50 | 650 | B292NQ7 |
| 0.03% | RGNX | REGENXBIO INC | -- | $20,638.84 | 2,273 | BZ0G875 |
| 0.02% | PEPG | PEPGEN INC | -- | $18,985.05 | 3,087 | BMTX3D7 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $18,651.15 | 4,011 | BYTYP72 |
| 0.02% | FULC | FULCRUM THERAPEUTICS INC | -- | $18,533.27 | 2,429 | BJDX8Z9 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $18,331.11 | 3,843 | BMXNGZ6 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $17,586.05 | 3,215 | 2107437 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $17,379.36 | 1,296 | B9L5200 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $17,250.59 | 1,967 | BSMLR16 |
| 0.02% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $17,214.85 | 13,555 | B4N8MH9 |
| 0.02% | ACRS | ACLARIS THERAPEUTICS INC | -- | $17,076.15 | 4,865 | BYV2W40 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $16,957.50 | 2,850 | BP81R42 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $16,866.00 | 4,685 | BFY7DC4 |
| 0.02% | LENZ | LENZ THERAPEUTICS INC | -- | $16,607.10 | 1,405 | BQV0J03 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $15,799.55 | 2,899 | BMVBZF5 |
| 0.02% | ABSI | ABSCI CORP | -- | $15,529.60 | 6,752 | BN94K69 |
| 0.02% | NGNE | NEUROGENE INC | -- | $15,498.50 | 695 | BS2F741 |
| 0.02% | KROS | KEROS THERAPEUTICS INC | -- | $15,034.32 | 1,368 | BM7V485 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $14,699.73 | 2,109 | BL5B6Z1 |
| 0.02% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $14,372.82 | 1,037 | BPRBTY7 |
| 0.02% | EOLS | EVOLUS INC | -- | $14,293.01 | 2,911 | BDRJH21 |
| 0.02% | CABA | CABALETTA BIO INC | -- | $13,783.99 | 4,321 | BK5MWR1 |
| 0.02% | NBP | NOVABRIDGE BIOSCIENCES | -- | $13,720.98 | 4,667 | BKRRKY7 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $13,524.00 | 4,508 | BZC0D70 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $13,300.56 | 2,262 | B7F2TY6 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $13,148.76 | 9,006 | BFMLGR4 |
| 0.02% | VYGR | VOYAGER THERAPEUTICS INC | -- | $12,881.15 | 2,645 | BY7RB53 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $12,491.88 | 2,539 | BMF7DT9 |
| 0.02% | CADL | CANDEL THERAPEUTICS INC | -- | $12,275.70 | 2,465 | BP0TQC5 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $11,965.25 | 4,351 | BKX9NQ0 |
| 0.01% | OABI | OMNIAB INC | -- | $11,956.55 | 6,463 | BN13S71 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $11,135.36 | 4,384 | BZ8FPH3 |
| 0.01% | LFCR | LIFECORE BIOMEDICAL INC | -- | $11,118.02 | 1,682 | 2517058 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $11,103.30 | 2,535 | BPRB2N7 |
| 0.01% | VOR | VOR BIOPHARMA INC | -- | $10,621.80 | 756 | BRJJYT3 |
| 0.01% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $10,463.04 | 2,076 | BKDQKM6 |
| 0.01% | HUMA | HUMACYTE INC | -- | $9,583.98 | 8,407 | BMYTJP4 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $9,171.63 | 5,427 | BRK0149 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $8,932.00 | 1,276 | BKC9SX3 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $8,569.28 | 8,780 | BNR5QT9 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $7,930.44 | 4,196 | BNYJR68 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $7,433.28 | 1,392 | BP2NYN2 |
| 0.01% | MENS | JYONG BIOTECH LTD | -- | $7,337.95 | 3,413 | BPTK6Z2 |
| 0.01% | CDXS | CODEXIS INC | -- | $6,934.05 | 4,055 | B5LL2C2 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $6,673.53 | 7,474 | BNNXX52 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $6,416.01 | 2,403 | BP7L561 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $5,650.20 | 4,380 | BNNXX18 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $5,450.67 | 2,559 | BKTV702 |
| 0.01% | AARD | AARDVARK THERAPEUTICS INC | -- | $5,139.02 | 977 | BTXQTX3 |
| 0.01% | GOSS | GOSSAMER BIO INC | -- | $4,779.86 | 10,391 | BJ0CK86 |
| 0.01% | PYXS | PYXIS ONCOLOGY INC | -- | $4,276.35 | 2,795 | BLBR8D5 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $24.45 | 01 | BTFHQP5 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| 31.74% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 25,714,424 | -- | 4,475 | -- |
| 30.43% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 24,657,116 | -- | 4,291 | -- |
| 27.14% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 21,985,114 | -- | 3,826 | -- |
| 18.72% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 15,164,327 | -- | 2,639 | -- |
| 17.62% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,273,660 | -- | 2,484 | -- |
| 4.49% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,637,370 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $23,944,573.53 | 23,944,574 | -- |
Index
as of 12/31/2025
- Total Number of Companies262
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$7.32 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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