BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 11/30/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 16.90% | 51.72% | 95.62% | 66.67% | 42.59% | 11.36% | 1.61% | 2.01% | 16.86% | 04/07/2010 |
| BIB Market Price | 17.00% | 51.90% | 95.85% | 66.74% | 42.98% | 11.47% | 1.66% | 2.03% | 16.87% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/22/2025- NAV $83.34
- NAV Change $+2.42
- Market Price $83.36
- Market Price Change $+2.53
- Trading Volume (M) 20,364
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/22/2025- NAV $83.34
- NAV Change $+2.42
- Market Price $83.36
- Market Price Change $+2.53
- Trading Volume (M) 20,364
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 12/22/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.83% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,101,155.42 | 11,082 | 2931034 |
| 5.42% | GILD | GILEAD SCIENCES INC | -- | $4,739,187.20 | 38,170 | 2369174 |
| 5.27% | AMGN | AMGEN INC | -- | $4,608,309.34 | 13,906 | 2023607 |
| 4.06% | REGN | REGENERON PHARMACEUTICALS | -- | $3,555,440.32 | 4,562 | 2730190 |
| 2.72% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,379,104.55 | 5,835 | B00FWN1 |
| 2.70% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $2,360,891.40 | 25,788 | 2989044 |
| 1.89% | INSM | INSMED INC | -- | $1,655,659.20 | 9,420 | 2614487 |
| 1.29% | BIIB | BIOGEN INC | -- | $1,132,056.00 | 6,480 | 2455965 |
| 1.25% | ARGX | ARGENX SE - ADR | -- | $1,095,723.44 | 1,286 | BDVLM39 |
| 1.12% | UTHR | UNITED THERAPEUTICS CORP | -- | $977,228.58 | 1,902 | 2430412 |
| 1.06% | ILMN | ILLUMINA INC | -- | $928,662.40 | 6,749 | 2613990 |
| 1.00% | INCY | INCYTE CORP | -- | $873,256.41 | 8,671 | 2471950 |
| 0.84% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $733,327.06 | 18,871 | BMVP7Y0 |
| 0.81% | MEDP | MEDPACE HOLDINGS INC | -- | $710,983.32 | 1,244 | BDCBC61 |
| 0.80% | ROIV | ROIVANT SCIENCES LTD | -- | $696,706.92 | 30,719 | BMW4NZ9 |
| 0.79% | RVMD | REVOLUTION MEDICINES INC | -- | $688,072.62 | 8,539 | BL71K91 |
| 0.75% | BBIO | BRIDGEBIO PHARMA INC | -- | $656,190.08 | 8,512 | BK1KWG8 |
| 0.74% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $649,722.12 | 4,404 | 2623911 |
| 0.70% | VTRS | VIATRIS INC | -- | $610,732.52 | 50,852 | BMWS3X9 |
| 0.69% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $604,638.49 | 1,003 | BD59BS7 |
| 0.69% | MRNA | MODERNA INC | -- | $602,059.90 | 17,251 | BGSXTS3 |
| 0.68% | SMMT | SUMMIT THERAPEUTICS INC | -- | $596,790.15 | 32,881 | BMTVQS7 |
| 0.66% | IONS | IONIS PHARMACEUTICALS INC | -- | $581,906.36 | 7,154 | BDJ0LS6 |
| 0.66% | GH | GUARDANT HEALTH INC | -- | $579,056.76 | 5,714 | BFXC911 |
| 0.65% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $567,974.16 | 2,712 | BV9G6B8 |
| 0.64% | SNY | SANOFI-ADR | -- | $561,374.64 | 11,688 | 2964557 |
| 0.63% | EXEL | EXELIXIS INC | -- | $546,981.98 | 11,842 | 2576941 |
| 0.58% | TEM | TEMPUS AI INC | -- | $503,299.20 | 7,635 | BSLSJJ0 |
| 0.57% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $502,516.56 | 8,477 | 2437071 |
| 0.55% | RNA | AVIDITY BIOSCIENCES INC | -- | $480,491.00 | 6,655 | BMWHPY1 |
| 0.52% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $455,394.28 | 2,684 | B4Q5ZN4 |
| 0.50% | ONC | BEONE MEDICINES LTD-ADR | -- | $435,570.40 | 1,390 | BYYWPW6 |
| 0.47% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $413,931.00 | 5,999 | BYQBFJ8 |
| 0.47% | BNTX | BIONTECH SE-ADR | -- | $411,446.88 | 4,464 | BK6H543 |
| 0.43% | CYTK | CYTOKINETICS INC | -- | $374,772.80 | 5,713 | BBBSBJ5 |
| 0.41% | -- | ABIVAX SA ADR USD 0.01 | -- | $361,643.04 | 2,607 | -- |
| 0.41% | -- | CARIS LIFE SCIENCES INC COMMON STOCK USD 0.001 | -- | $354,668.52 | 12,462 | -- |
| 0.40% | HALO | HALOZYME THERAPEUTICS INC | -- | $354,023.04 | 5,194 | 2975098 |
| 0.39% | AXSM | AXSOME THERAPEUTICS INC | -- | $344,516.90 | 2,227 | BYZR4X4 |
| 0.39% | NUVL | NUVALENT INC-A | -- | $337,246.80 | 3,190 | BMVBZD3 |
| 0.38% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $332,770.24 | 2,948 | BF2YWG4 |
| 0.37% | KRYS | KRYSTAL BIOTECH INC | -- | $319,750.41 | 1,281 | BD6JX35 |
| 0.35% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $309,842.00 | 1,105 | BQ721R4 |
| 0.32% | PTCT | PTC THERAPEUTICS INC | -- | $279,779.40 | 3,546 | B17VCN9 |
| 0.32% | PCVX | VAXCYTE INC | -- | $278,133.02 | 5,786 | BKPVGH6 |
| 0.31% | KYMR | KYMERA THERAPEUTICS INC | -- | $268,064.30 | 3,178 | BMPRZV5 |
| 0.30% | COGT | COGENT BIOSCIENCES INC | -- | $266,607.18 | 6,777 | BLR6XK8 |
| 0.28% | CRSP | CRISPR THERAPEUTICS AG | -- | $243,279.91 | 4,201 | BDHF4K6 |
| 0.28% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $241,339.01 | 2,761 | BDCBCD8 |
| 0.24% | IMVT | IMMUNOVANT INC | -- | $213,159.60 | 7,740 | BJRFSB7 |
| 0.24% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $209,692.38 | 7,473 | 2713317 |
| 0.24% | ADMA | ADMA BIOLOGICS INC | -- | $208,978.56 | 10,512 | B9NSBM2 |
| 0.24% | ALKS | ALKERMES PLC | -- | $208,884.48 | 7,296 | B3P6D26 |
| 0.24% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $206,364.84 | 4,191 | BDD19F8 |
| 0.23% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $203,671.20 | 4,506 | BFZQ0L8 |
| 0.23% | INDV | INDIVIOR PLC | -- | $201,021.75 | 5,515 | BP0BQQ5 |
| 0.22% | FOLD | AMICUS THERAPEUTICS INC | -- | $193,653.88 | 13,628 | B19FQ48 |
| 0.22% | APGE | APOGEE THERAPEUTICS INC | -- | $188,916.00 | 2,422 | BM9HHL5 |
| 0.21% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $187,030.25 | 2,957 | BQS9486 |
| 0.21% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $184,028.90 | 2,270 | BJDX8Y8 |
| 0.21% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $182,741.92 | 5,008 | BP8JSP4 |
| 0.20% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $177,941.60 | 13,880 | BFNF1D6 |
| 0.20% | LGND | LIGAND PHARMACEUTICALS | -- | $172,027.24 | 869 | 2501578 |
| 0.19% | ACLX | ARCELLX INC | -- | $166,469.72 | 2,554 | BPCJ1Q2 |
| 0.19% | GRAL | GRAIL INC | -- | $162,470.70 | 1,722 | BSLSSX7 |
| 0.18% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $161,759.00 | 5,410 | BKX9VD3 |
| 0.18% | TERN | TERNS PHARMACEUTICALS INC | -- | $161,706.56 | 3,979 | BMDJ0C9 |
| 0.18% | XENE | XENON PHARMACEUTICALS INC | -- | $157,271.04 | 3,413 | BRJ3GY4 |
| 0.18% | TARS | TARSUS PHARMACEUTICALS INC | -- | $153,712.50 | 1,875 | BMH5RL1 |
| 0.17% | VERA | VERA THERAPEUTICS INC | -- | $151,874.72 | 2,824 | BL55460 |
| 0.17% | VCYT | VERACYTE INC | -- | $150,685.73 | 3,497 | BFTWZY0 |
| 0.17% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $148,069.75 | 4,261 | BJ62Z18 |
| 0.16% | TVTX | TRAVERE THERAPEUTICS INC | -- | $144,248.00 | 3,952 | BLFGJD5 |
| 0.16% | CGON | CG ONCOLOGY INC | -- | $142,644.72 | 3,559 | BRBCSP4 |
| 0.16% | APLS | APELLIS PHARMACEUTICALS INC | -- | $141,935.20 | 5,588 | BYTQ6X1 |
| 0.16% | IDYA | IDEAYA BIOSCIENCES INC | -- | $137,456.00 | 3,872 | BK0VHF6 |
| 0.15% | WVE | WAVE LIFE SCIENCES LTD | -- | $132,690.48 | 7,384 | BYZG9R0 |
| 0.15% | IRON | DISC MEDICINE INC | -- | $132,593.18 | 1,667 | BMGJZJ8 |
| 0.15% | MLYS | MINERALYS THERAPEUTICS INC | -- | $131,309.76 | 3,496 | BP9N0G0 |
| 0.15% | DYN | DYNE THERAPEUTICS INC | -- | $131,080.24 | 6,308 | BN15WD1 |
| 0.15% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $130,449.50 | 2,533 | B72ZBG4 |
| 0.14% | BEAM | BEAM THERAPEUTICS INC | -- | $125,137.44 | 4,482 | BK6L288 |
| 0.14% | OCUL | OCULAR THERAPEUTIX INC | -- | $121,901.76 | 9,406 | BNZB1X8 |
| 0.13% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $117,395.63 | 6,743 | BJ5FZ74 |
| 0.13% | SYRE | SPYRE THERAPEUTICS INC | -- | $117,203.40 | 3,427 | BQBBDY8 |
| 0.13% | DNLI | DENALI THERAPEUTICS INC | -- | $113,170.66 | 6,478 | BD2B4V0 |
| 0.12% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $108,144.18 | 4,261 | BLB0YQ9 |
| 0.11% | ZBIO | ZENAS BIOPHARMA INC | -- | $100,364.43 | 2,371 | BQB42H3 |
| 0.11% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $99,928.40 | 22,711 | BM9FJ13 |
| 0.11% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $98,859.84 | 2,544 | BKSGZN7 |
| 0.11% | IBRX | IMMUNITYBIO INC | -- | $98,756.35 | 43,505 | BNSP0B8 |
| 0.11% | SRPT | SAREPTA THERAPEUTICS INC | -- | $98,018.91 | 4,617 | B8DPDT7 |
| 0.11% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $97,915.44 | 4,676 | BKY5JZ8 |
| 0.11% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $97,897.32 | 3,474 | BMZ4LN0 |
| 0.11% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $94,973.13 | 5,823 | BFWLC09 |
| 0.11% | TWST | TWIST BIOSCIENCE CORP | -- | $94,626.94 | 2,699 | BGKG6G7 |
| 0.10% | ZYME | ZYMEWORKS INC | -- | $91,284.10 | 3,305 | BPCQZY9 |
| 0.10% | MAZE | MAZE THERAPEUTICS INC | -- | $89,207.50 | 2,125 | BSRK699 |
| 0.10% | TXG | 10X GENOMICS INC-CLASS A | -- | $87,173.24 | 5,146 | BKS3RS7 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $86,822.40 | 1,995 | BRXB0C0 |
| 0.10% | NRIX | NURIX THERAPEUTICS INC | -- | $86,585.18 | 4,477 | BMVLGP2 |
| 0.10% | GMAB | GENMAB A/S -SP ADR | -- | $85,360.92 | 2,582 | BBC9WC7 |
| 0.10% | STOK | STOKE THERAPEUTICS INC | -- | $84,570.96 | 2,523 | BJQ05Z6 |
| 0.10% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $84,384.11 | 3,719 | BMX9K07 |
| 0.10% | SION | SIONNA THERAPEUTICS INC | -- | $83,609.82 | 1,971 | BQKXDX4 |
| 0.10% | VCEL | VERICEL CORP | -- | $83,484.58 | 2,234 | BSBMN89 |
| 0.09% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $82,461.72 | 3,839 | BN7Q7R7 |
| 0.09% | MNKD | MANNKIND CORP | -- | $81,242.37 | 13,563 | BF081J4 |
| 0.09% | HROW | HARROW INC | -- | $80,785.68 | 1,636 | BHNDW86 |
| 0.09% | ANIP | ANI PHARMACEUTICALS INC | -- | $80,074.24 | 992 | BCDWBX6 |
| 0.09% | -- | PHARVARIS NV COMMON STOCK USD 0.12 | -- | $76,581.03 | 2,829 | -- |
| 0.08% | UPB | UPSTREAM BIO INC | -- | $72,636.41 | 2,387 | BRCFFK6 |
| 0.08% | FTRE | FORTREA HOLDINGS INC | -- | $72,192.89 | 4,081 | BRXYZ57 |
| 0.08% | TRVI | TREVI THERAPEUTICS INC | -- | $72,159.36 | 5,664 | BJH9ZN0 |
| 0.08% | TSHA | TAYSHA GENE THERAPIES INC | -- | $70,900.14 | 12,099 | BNC1BX1 |
| 0.08% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $70,765.39 | 9,299 | 2100362 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $69,333.46 | 1,927 | BLCD809 |
| 0.08% | MBX | MBX BIOSCIENCES INC | -- | $69,008.40 | 1,983 | BQXJKH2 |
| 0.08% | ATAI | ATAI LIFE SCIENCES NV | -- | $68,980.60 | 16,042 | BN6M8F1 |
| 0.08% | EYPT | EYEPOINT INC | -- | $68,934.45 | 3,657 | BMGS7L1 |
| 0.08% | QURE | UNIQURE NV | -- | $68,719.98 | 2,751 | BJFSR88 |
| 0.08% | ORKA | ORUKA THERAPEUTICS INC | -- | $68,351.86 | 2,138 | BKVF0J2 |
| 0.08% | ALVO | ALVOTECH SA | -- | $68,300.44 | 13,826 | BPNTJ34 |
| 0.08% | PGEN | PRECIGEN INC | -- | $68,297.34 | 15,593 | BKM5C84 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $68,180.64 | 1,396 | BX7RSN3 |
| 0.08% | RAPP | RAPPORT THERAPEUTICS INC | -- | $67,213.30 | 2,107 | BR3T9B6 |
| 0.08% | KOD | KODIAK SCIENCES INC | -- | $67,033.23 | 2,343 | BFXC933 |
| 0.08% | NVCR | NOVOCURE LTD | -- | $66,474.24 | 4,946 | BYSS4X4 |
| 0.08% | INVA | INNOVIVA INC | -- | $66,026.97 | 3,303 | BDDXF67 |
| 0.08% | RLAY | RELAY THERAPEUTICS INC | -- | $65,909.55 | 7,655 | BN2R582 |
| 0.07% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $64,271.20 | 2,576 | BCBVTX1 |
| 0.07% | ARDX | ARDELYX INC | -- | $62,674.88 | 10,732 | BN89V40 |
| 0.07% | ANAB | ANAPTYSBIO INC | -- | $61,553.59 | 1,223 | BDRW1L7 |
| 0.07% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $60,637.50 | 4,851 | BPCK358 |
| 0.07% | TYRA | TYRA BIOSCIENCES INC | -- | $59,820.66 | 2,357 | BMVNDH9 |
| 0.07% | SEPN | SEPTERNA INC | -- | $58,291.66 | 1,978 | BQNKXX2 |
| 0.07% | SVRA | SAVARA INC | -- | $58,145.89 | 8,987 | BYXGN81 |
| 0.07% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $57,886.92 | 5,187 | BRJZSK0 |
| 0.07% | MNMD | MIND MEDICINE MINDMED INC | -- | $57,868.30 | 4,351 | BPQYY97 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $56,187.84 | 642 | BNSP8K3 |
| 0.06% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $56,147.54 | 3,142 | BJLKVS6 |
| 0.06% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $55,459.60 | 2,030 | BNFWZS4 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $53,766.05 | 11,765 | BMFJJ97 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $53,351.71 | 1,289 | BKLCWZ3 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $52,842.09 | 7,329 | BLR7H87 |
| 0.06% | TNGX | TANGO THERAPEUTICS INC | -- | $51,280.38 | 5,949 | BP2P6L0 |
| 0.06% | XNCR | XENCOR INC | -- | $50,369.38 | 3,154 | BGCYWN8 |
| 0.06% | SPRY | ARS PHARMACEUTICALS INC | -- | $49,597.76 | 4,366 | BMCR7V2 |
| 0.06% | NTLA | INTELLIA THERAPEUTICS INC | -- | $49,576.70 | 5,111 | BYZM6C2 |
| 0.06% | NVAX | NOVAVAX INC | -- | $49,449.53 | 7,177 | BJDQXG4 |
| 0.06% | PCRX | PACIRA BIOSCIENCES INC | -- | $49,438.00 | 1,900 | B3X26D8 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $49,252.80 | 13,240 | BL53SR3 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $48,923.04 | 5,388 | B8K7T65 |
| 0.06% | URGN | UROGEN PHARMA LTD | -- | $48,763.44 | 2,068 | BZ7PJQ1 |
| 0.06% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $48,744.52 | 17,534 | BF0DMK7 |
| 0.05% | ALMS | ALUMIS INC | -- | $48,006.92 | 4,294 | BPLQG36 |
| 0.05% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $46,994.53 | 2,621 | BMFD115 |
| 0.05% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $46,562.44 | 2,876 | BP7KZP7 |
| 0.05% | ERAS | ERASCA INC | -- | $45,738.15 | 12,531 | BNLYBF3 |
| 0.05% | -- | RAPT THERAPEUTICS INC | -- | $44,639.28 | 1,224 | BTJZB49 |
| 0.05% | BCAX | BICARA THERAPEUTICS INC | -- | $44,334.40 | 2,420 | BQB42F1 |
| 0.05% | KURA | KURA ONCOLOGY INC | -- | $43,231.72 | 3,836 | BYZD465 |
| 0.05% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $43,151.13 | 4,509 | BLB0YH0 |
| 0.05% | CRMD | CORMEDIX INC | -- | $43,117.20 | 3,480 | BJ0LT31 |
| 0.05% | ESPR | ESPERION THERAPEUTICS INC | -- | $42,658.36 | 10,559 | BBNBTD2 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $42,115.59 | 2,239 | BMNDK09 |
| 0.05% | MESO | MESOBLAST LTD- SPON ADR | -- | $42,063.72 | 2,166 | BQS7491 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $40,835.20 | 1,823 | BMGTLY5 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $40,096.40 | 8,495 | BZ0QMB7 |
| 0.04% | GOSS | GOSSAMER BIO INC | -- | $38,540.71 | 10,223 | BJ0CK86 |
| 0.04% | GERN | GERON CORP | -- | $38,064.60 | 28,196 | 2370381 |
| 0.04% | JANX | JANUX THERAPEUTICS INC | -- | $37,437.13 | 2,657 | BMFX8Y7 |
| 0.04% | VIR | VIR BIOTECHNOLOGY INC | -- | $36,931.45 | 6,145 | BK4PZ38 |
| 0.04% | ORIC | ORIC PHARMACEUTICALS INC | -- | $36,136.80 | 4,302 | BKVDFF7 |
| 0.04% | -- | GH RESEARCH PLC COMMON STOCK USD 0.01 | -- | $35,674.80 | 2,740 | -- |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $35,416.32 | 802 | BQD3J33 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $35,370.72 | 2,233 | BD06CS0 |
| 0.04% | IVVD | INVIVYD INC | -- | $35,251.20 | 12,240 | BM8NHS1 |
| 0.04% | LYEL | LYELL IMMUNOPHARMA INC | -- | $35,015.69 | 937 | BTNMG41 |
| 0.04% | ARVN | ARVINAS INC | -- | $34,951.84 | 2,837 | BDZ30Q0 |
| 0.04% | REPL | REPLIMUNE GROUP INC | -- | $34,407.45 | 3,465 | BDDVW37 |
| 0.04% | LXEO | LEXEO THERAPEUTICS INC | -- | $34,271.12 | 3,224 | BQ6C357 |
| 0.04% | PSNL | PERSONALIS INC | -- | $34,164.96 | 3,918 | BJQ0608 |
| 0.04% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $34,160.49 | 903 | BL95N25 |
| 0.04% | RGNX | REGENXBIO INC | -- | $33,472.92 | 2,236 | BZ0G875 |
| 0.04% | ANNX | ANNEXON INC | -- | $33,179.67 | 6,393 | BMVV9R5 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $32,118.44 | 5,389 | BYVQJ96 |
| 0.04% | CTMX | CYTOMX THERAPEUTICS INC | -- | $30,834.08 | 7,484 | BYWVTY5 |
| 0.03% | ZLAB | ZAI LAB LTD-ADR | -- | $30,620.59 | 1,729 | BD9GVY0 |
| 0.03% | FULC | FULCRUM THERAPEUTICS INC | -- | $30,544.20 | 2,390 | BJDX8Z9 |
| 0.03% | OMER | OMEROS CORP | -- | $29,785.32 | 3,132 | B4NB858 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $29,506.50 | 3,555 | BFYQFJ2 |
| 0.03% | PRME | PRIME MEDICINE INC | -- | $29,500.10 | 7,973 | BPBJFM7 |
| 0.03% | VTYX | VENTYX BIOSCIENCES INC | -- | $29,439.68 | 3,152 | BMG99Y1 |
| 0.03% | KROS | KEROS THERAPEUTICS INC | -- | $28,723.64 | 1,346 | BM7V485 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $27,177.86 | 4,162 | BMC3HS7 |
| 0.03% | CGEM | CULLINAN THERAPEUTICS INC | -- | $26,977.06 | 2,609 | BM90J52 |
| 0.03% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $25,732.20 | 3,299 | BYP80F1 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $25,059.36 | 2,516 | BMFK3H6 |
| 0.03% | ABSI | ABSCI CORP | -- | $24,376.14 | 6,642 | BN94K69 |
| 0.03% | LENZ | LENZ THERAPEUTICS INC | -- | $24,350.84 | 1,382 | BQV0J03 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $24,269.70 | 13,335 | B4N8MH9 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $23,207.55 | 7,185 | B3MZ6K5 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $23,019.04 | 2,378 | B91XRN2 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $22,421.00 | 6,406 | BMCWKZ2 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $21,984.04 | 2,524 | BKLXFX5 |
| 0.02% | BIOA | BIOAGE LABS INC | -- | $21,510.72 | 1,584 | BT9K6D8 |
| 0.02% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $21,263.85 | 2,487 | BLFBZ32 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $20,754.72 | 639 | B292NQ7 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $20,667.75 | 1,275 | B9L5200 |
| 0.02% | EOLS | EVOLUS INC | -- | $20,584.97 | 2,863 | BDRJH21 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $20,577.18 | 3,441 | BQHN6C7 |
| 0.02% | IMAB | I-MAB-SPONSORED ADR | -- | $20,158.88 | 4,592 | BKRRKY7 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $19,768.75 | 3,163 | 2107437 |
| 0.02% | ETON | ETON PHARMACEUTICALS INC | -- | $19,635.45 | 1,185 | BGL0JK3 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $19,081.26 | 4,609 | BFY7DC4 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $18,348.30 | 2,610 | B12W3P6 |
| 0.02% | KMDA | KAMADA LTD | -- | $18,014.36 | 2,548 | B2Q9833 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $17,926.56 | 1,688 | BP81RK8 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $17,706.07 | 827 | BPBPCG8 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $16,886.10 | 2,805 | BP81R42 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $16,873.40 | 4,780 | BDFKQ07 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $16,855.32 | 2,852 | BMVBZF5 |
| 0.02% | PEPG | PEPGEN INC | -- | $16,521.28 | 3,037 | BMTX3D7 |
| 0.02% | -- | JYONG BIOTECH LTD COMMON STOCK USD 0.00001 | -- | $16,051.24 | 3,358 | -- |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $15,764.07 | 1,939 | BSMLR16 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $15,327.80 | 8,860 | BFMLGR4 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $15,120.00 | 3,780 | BMXNGZ6 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $14,797.50 | 3,946 | BYTYP72 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $14,696.36 | 2,044 | BKDQKM6 |
| 0.02% | ACRS | ACLARIS THERAPEUTICS INC | -- | $14,693.02 | 4,786 | BYV2W40 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $14,591.22 | 9,926 | BFZNYB7 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $14,438.44 | 2,498 | BMF7DT9 |
| 0.02% | CADL | CANDEL THERAPEUTICS INC | -- | $14,404.50 | 2,425 | BP0TQC5 |
| 0.02% | NGNE | NEUROGENE INC | -- | $14,261.40 | 684 | BS2F741 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $14,103.30 | 4,435 | BZC0D70 |
| 0.02% | AARD | AARDVARK THERAPEUTICS INC | -- | $13,997.10 | 962 | BTXQTX3 |
| 0.02% | LFCR | LIFECORE BIOMEDICAL INC | -- | $13,521.35 | 1,655 | 2517058 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $13,377.30 | 2,074 | BL5B6Z1 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $13,357.80 | 7,380 | BN4JN37 |
| 0.01% | OABI | OMNIAB INC | -- | $13,033.90 | 6,358 | BN13S71 |
| 0.01% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $12,977.58 | 2,226 | B7F2TY6 |
| 0.01% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $12,505.20 | 1,020 | BPRBTY7 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $10,998.54 | 2,494 | BPRB2N7 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $10,971.26 | 2,606 | BY7RB53 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $10,968.99 | 8,637 | BNR5QT9 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $10,939.67 | 3,451 | BLN9Z50 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $10,543.44 | 2,364 | BP7L561 |
| 0.01% | -- | VOR BIOPHARMA INC COMMON STOCK USD 0.0001 | -- | $10,200.24 | 744 | -- |
| 0.01% | CABA | CABALETTA BIO INC | -- | $10,162.28 | 4,252 | BK5MWR1 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $10,046.96 | 4,312 | BZ8FPH3 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $8,947.29 | 4,281 | BKX9NQ0 |
| 0.01% | HUMA | HUMACYTE INC | -- | $8,851.04 | 8,272 | BMYTJP4 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $8,542.56 | 1,369 | BP2NYN2 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $8,270.45 | 1,255 | BKC9SX3 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $7,474.60 | 5,339 | BRK0149 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $7,100.16 | 4,128 | BNYJR68 |
| 0.01% | CDXS | CODEXIS INC | -- | $6,783.00 | 3,990 | B5LL2C2 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $6,544.20 | 2,517 | BKTV702 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $6,418.92 | 4,308 | BNNXX18 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $5,567.71 | 7,354 | BNNXX52 |
| -- | PYXS | PYXIS ONCOLOGY INC | -- | $3,272.50 | 2,750 | BLBR8D5 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 36.68% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 32,096,946 | -- | 5,511 | -- |
| 33.33% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 29,167,393 | -- | 5,008 | -- |
| 25.33% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 22,166,753 | -- | 3,806 | -- |
| 16.53% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,467,213 | -- | 2,484 | -- |
| 15.30% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 13,389,744 | -- | 2,299 | -- |
| 4.21% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,686,693 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $27,417,620.43 | 27,417,620 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
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