BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 1/31/2026
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 4.27% | 16.53% | 65.39% | 4.27% | 51.38% | 11.58% | -2.47% | 6.91% | 16.64% | 04/07/2010 |
| BIB Market Price | 4.19% | 16.41% | 65.44% | 4.19% | 51.07% | 11.50% | -2.49% | 6.94% | 16.64% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 2/23/2026- NAV $87.49
- NAV Change $+0.99
- Market Price $87.37
- Market Price Change $+0.96
- Trading Volume (M) 5,743
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 2/23/2026- NAV $87.49
- NAV Change $+0.99
- Market Price $87.37
- Market Price Change $+0.96
- Trading Volume (M) 5,743
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 12/31/2025
Holdings
as of 2/20/2026
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 6.75% | GILD | GILEAD SCIENCES INC | -- | $6,126,098.20 | 40,463 | 2369174 |
| 6.17% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,600,236.70 | 11,743 | 2931034 |
| 6.08% | AMGN | AMGEN INC | -- | $5,523,440.25 | 14,739 | 2023607 |
| 4.15% | REGN | REGENERON PHARMACEUTICALS | -- | $3,770,484.12 | 4,836 | 2730190 |
| 2.29% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,079,671.34 | 6,186 | B00FWN1 |
| 1.81% | INSM | INSMED INC | -- | $1,646,791.26 | 9,986 | 2614487 |
| 1.45% | BIIB | BIOGEN INC | -- | $1,319,054.07 | 6,869 | 2455965 |
| 1.27% | ARGX | ARGENX SE - ADR | -- | $1,150,930.83 | 1,363 | BDVLM39 |
| 1.05% | UTHR | UNITED THERAPEUTICS CORP | -- | $954,414.72 | 2,016 | 2430412 |
| 1.03% | INCY | INCYTE CORP | -- | $931,333.44 | 9,192 | 2471950 |
| 1.01% | RVMD | REVOLUTION MEDICINES INC | -- | $921,765.16 | 9,052 | BL71K91 |
| 1.00% | MRNA | MODERNA INC | -- | $912,222.04 | 18,292 | BGSXTS3 |
| 0.99% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $902,625.60 | 20,005 | BMVP7Y0 |
| 0.97% | ROIV | ROIVANT SCIENCES LTD | -- | $884,112.60 | 32,564 | BMW4NZ9 |
| 0.95% | VTRS | VIATRIS INC | -- | $858,533.76 | 53,928 | BMWS3X9 |
| 0.93% | ILMN | ILLUMINA INC | -- | $841,811.18 | 7,154 | 2613990 |
| 0.71% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $646,875.00 | 2,875 | BV9G6B8 |
| 0.69% | IONS | IONIS PHARMACEUTICALS INC | -- | $630,609.60 | 7,584 | BDJ0LS6 |
| 0.69% | GH | GUARDANT HEALTH INC | -- | $624,579.80 | 6,058 | BFXC911 |
| 0.68% | BBIO | BRIDGEBIO PHARMA INC | -- | $614,759.08 | 9,022 | BK1KWG8 |
| 0.66% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $600,444.84 | 4,668 | 2623911 |
| 0.66% | MEDP | MEDPACE HOLDINGS INC | -- | $598,522.63 | 1,319 | BDCBC61 |
| 0.64% | SNY | SANOFI-ADR | -- | $579,356.40 | 12,390 | 2964557 |
| 0.63% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $576,399.60 | 8,995 | 2437071 |
| 0.61% | SMMT | SUMMIT THERAPEUTICS INC | -- | $555,604.64 | 34,856 | BMTVQS7 |
| 0.60% | EXEL | EXELIXIS INC | -- | $547,731.02 | 12,554 | 2576941 |
| 0.59% | ONC | BEONE MEDICINES LTD-ADR | -- | $533,794.36 | 1,474 | BYYWPW6 |
| 0.57% | BNTX | BIONTECH SE-ADR | -- | $521,426.43 | 4,734 | BK6H543 |
| 0.57% | RNA | AVIDITY BIOSCIENCES INC | -- | $514,027.30 | 7,055 | BMWHPY1 |
| 0.54% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $489,880.55 | 2,845 | B4Q5ZN4 |
| 0.52% | TEM | TEMPUS AI INC | -- | $472,446.78 | 8,094 | BSLSJJ0 |
| 0.51% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $462,415.63 | 1,063 | BD59BS7 |
| 0.48% | AXSM | AXSOME THERAPEUTICS INC | -- | $433,579.20 | 2,360 | BYZR4X4 |
| 0.45% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $404,368.81 | 6,359 | BYQBFJ8 |
| 0.44% | IBRX | IMMUNITYBIO INC | -- | $401,226.60 | 46,118 | BNSP0B8 |
| 0.43% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $392,612.88 | 1,171 | BQ721R4 |
| 0.43% | HALO | HALOZYME THERAPEUTICS INC | -- | $390,815.88 | 5,506 | 2975098 |
| 0.43% | CYTK | CYTOKINETICS INC | -- | $388,956.50 | 5,725 | BBBSBJ5 |
| 0.40% | ABVX | ABIVAX SA-ADR | -- | $360,287.40 | 2,764 | BLC89B2 |
| 0.39% | PCVX | VAXCYTE INC | -- | $358,607.79 | 6,129 | BKPVGH6 |
| 0.39% | KRYS | KRYSTAL BIOTECH INC | -- | $355,524.40 | 1,358 | BD6JX35 |
| 0.37% | NUVL | NUVALENT INC-A | -- | $339,891.00 | 3,382 | BMVBZD3 |
| 0.34% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $311,812.50 | 3,125 | BF2YWG4 |
| 0.32% | KYMR | KYMERA THERAPEUTICS INC | -- | $294,450.60 | 3,369 | BMPRZV5 |
| 0.30% | COGT | COGENT BIOSCIENCES INC | -- | $268,362.58 | 7,187 | BLR6XK8 |
| 0.29% | PTCT | PTC THERAPEUTICS INC | -- | $265,610.94 | 3,759 | B17VCN9 |
| 0.28% | CAI | CARIS LIFE SCIENCES INC | -- | $258,010.83 | 13,211 | BT18HP9 |
| 0.28% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $253,014.96 | 2,406 | BJDX8Y8 |
| 0.27% | ALKS | ALKERMES PLC | -- | $246,696.21 | 7,731 | B3P6D26 |
| 0.27% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $242,238.52 | 2,927 | BDCBCD8 |
| 0.26% | CRSP | CRISPR THERAPEUTICS AG | -- | $238,538.52 | 4,462 | BDHF4K6 |
| 0.25% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $229,248.00 | 4,776 | BFZQ0L8 |
| 0.24% | IMVT | IMMUNOVANT INC | -- | $218,306.20 | 8,207 | BJRFSB7 |
| 0.24% | CGON | CG ONCOLOGY INC | -- | $217,668.51 | 3,777 | BRBCSP4 |
| 0.23% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $213,425.50 | 14,719 | BFNF1D6 |
| 0.23% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $208,234.95 | 3,129 | BQS9486 |
| 0.23% | FOLD | AMICUS THERAPEUTICS INC | -- | $207,155.64 | 14,446 | B19FQ48 |
| 0.22% | INDV | INDIVIOR PHARMACEUTICALS INC | -- | $198,053.16 | 5,844 | BTZRLN8 |
| 0.21% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $193,003.92 | 4,443 | BDD19F8 |
| 0.21% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $190,024.79 | 7,921 | 2713317 |
| -- | -- | NEWAMSTERDAM PHARMA CO NV | -- | $188,894.22 | 5,309 | BP8JSP4 |
| 0.20% | ADMA | ADMA BIOLOGICS INC | -- | $179,418.40 | 11,144 | B9NSBM2 |
| 0.19% | APGE | APOGEE THERAPEUTICS INC | -- | $175,557.13 | 2,567 | BM9HHL5 |
| 0.19% | ACLX | ARCELLX INC | -- | $173,545.77 | 2,707 | BPCJ1Q2 |
| 0.19% | LGND | LIGAND PHARMACEUTICALS | -- | $169,629.56 | 922 | 2501578 |
| 0.18% | ERAS | ERASCA INC | -- | $166,581.36 | 13,284 | BNLYBF3 |
| 0.18% | TERN | TERNS PHARMACEUTICALS INC | -- | $165,472.14 | 4,218 | BMDJ0C9 |
| 0.17% | SYRE | SPYRE THERAPEUTICS INC | -- | $156,981.93 | 3,633 | BQBBDY8 |
| 0.17% | XENE | XENON PHARMACEUTICALS INC | -- | $152,788.14 | 3,618 | BRJ3GY4 |
| 0.16% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $145,755.03 | 5,735 | BKX9VD3 |
| 0.16% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $145,289.67 | 4,957 | BKY5JZ8 |
| 0.15% | TWST | TWIST BIOSCIENCE CORP | -- | $139,113.17 | 2,863 | BGKG6G7 |
| 0.15% | DNLI | DENALI THERAPEUTICS INC | -- | $138,644.73 | 6,867 | BD2B4V0 |
| 0.15% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $136,559.10 | 2,685 | B72ZBG4 |
| 0.15% | TARS | TARSUS PHARMACEUTICALS INC | -- | $132,420.68 | 1,988 | BMH5RL1 |
| 0.15% | APLS | APELLIS PHARMACEUTICALS INC | -- | $131,919.88 | 5,921 | BYTQ6X1 |
| 0.15% | VCYT | VERACYTE INC | -- | $131,866.63 | 3,701 | BFTWZY0 |
| 0.14% | IDYA | IDEAYA BIOSCIENCES INC | -- | $131,277.90 | 4,105 | BK0VHF6 |
| 0.14% | BEAM | BEAM THERAPEUTICS INC | -- | $131,080.09 | 4,751 | BK6L288 |
| 0.14% | ALMS | ALUMIS INC | -- | $127,319.44 | 4,552 | BPLQG36 |
| 0.14% | TVTX | TRAVERE THERAPEUTICS INC | -- | $127,303.71 | 4,189 | BLFGJD5 |
| 0.14% | VERA | VERA THERAPEUTICS INC | -- | $124,904.16 | 2,991 | BL55460 |
| 0.12% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $110,666.50 | 4,517 | BLB0YQ9 |
| 0.12% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $108,649.60 | 7,148 | BJ5FZ74 |
| 0.12% | IRON | DISC MEDICINE INC | -- | $108,484.48 | 1,768 | BMGJZJ8 |
| 0.12% | WVE | WAVE LIFE SCIENCES LTD | -- | $105,640.19 | 7,831 | BYZG9R0 |
| 0.11% | MLYS | MINERALYS THERAPEUTICS INC | -- | $103,295.40 | 3,705 | BP9N0G0 |
| 0.11% | TXG | 10X GENOMICS INC-CLASS A | -- | $102,971.52 | 5,454 | BKS3RS7 |
| 0.11% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $102,626.24 | 4,517 | BJ62Z18 |
| 0.11% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $101,033.55 | 2,115 | BRXB0C0 |
| 0.11% | MAZE | MAZE THERAPEUTICS INC | -- | $99,627.66 | 2,253 | BSRK699 |
| 0.11% | DYN | DYNE THERAPEUTICS INC | -- | $99,502.56 | 6,687 | BN15WD1 |
| 0.10% | SRPT | SAREPTA THERAPEUTICS INC | -- | $92,625.28 | 4,906 | B8DPDT7 |
| 0.10% | STOK | STOKE THERAPEUTICS INC | -- | $91,725.75 | 2,675 | BJQ05Z6 |
| 0.10% | GRAL | GRAIL INC | -- | $91,633.25 | 1,825 | BSLSSX7 |
| 0.10% | VCEL | VERICEL CORP | -- | $90,197.12 | 2,368 | BSBMN89 |
| 0.10% | HROW | HARROW INC | -- | $90,168.00 | 1,734 | BHNDW86 |
| 0.10% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $88,891.20 | 6,173 | BFWLC09 |
| 0.10% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $88,686.64 | 3,683 | BMZ4LN0 |
| 0.09% | PHVS | PHARVARIS NV | -- | $84,271.90 | 2,999 | BMZ2X38 |
| 0.09% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $82,336.50 | 24,075 | BM9FJ13 |
| 0.09% | INVA | INNOVIVA INC | -- | $81,888.39 | 3,501 | BDDXF67 |
| 0.09% | ANIP | ANI PHARMACEUTICALS INC | -- | $81,814.04 | 1,052 | BCDWBX6 |
| 0.09% | GMAB | GENMAB A/S -SP ADR | -- | $80,166.73 | 2,737 | BBC9WC7 |
| 0.09% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $80,138.30 | 4,070 | BN7Q7R7 |
| 0.09% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $79,852.50 | 2,730 | BCBVTX1 |
| 0.09% | MNKD | MANNKIND CORP | -- | $79,654.12 | 14,378 | BF081J4 |
| 0.09% | ZYME | ZYMEWORKS INC | -- | $79,610.88 | 3,504 | BPCQZY9 |
| 0.09% | DFTX | DEFINIUM THERAPEUTICS INC | -- | $79,003.56 | 4,612 | BV2DHY6 |
| 0.09% | TYRA | TYRA BIOSCIENCES INC | -- | $78,918.42 | 2,499 | BMVNDH9 |
| 0.09% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $78,644.52 | 2,697 | BKSGZN7 |
| 0.09% | OCUL | OCULAR THERAPEUTIX INC | -- | $77,605.50 | 9,975 | BNZB1X8 |
| 0.08% | TNGX | TANGO THERAPEUTICS INC | -- | $76,933.20 | 6,306 | BP2P6L0 |
| 0.08% | RAPT | RAPT THERAPEUTICS INC | -- | $75,122.24 | 1,297 | BTJZB49 |
| 0.08% | NRIX | NURIX THERAPEUTICS INC | -- | $74,891.88 | 4,746 | BMVLGP2 |
| 0.08% | SION | SIONNA THERAPEUTICS INC | -- | $74,174.10 | 2,090 | BQKXDX4 |
| 0.08% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $73,442.10 | 9,858 | 2100362 |
| 0.08% | ORKA | ORUKA THERAPEUTICS INC | -- | $73,314.78 | 2,267 | BKVF0J2 |
| 0.08% | MBX | MBX BIOSCIENCES INC | -- | $73,128.58 | 2,102 | BQXJKH2 |
| 0.08% | PGEN | PRECIGEN INC | -- | $72,563.46 | 16,567 | BKM5C84 |
| 0.08% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $72,309.58 | 2,779 | BMFD115 |
| 0.08% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $72,039.42 | 5,142 | BPCK358 |
| 0.08% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $71,429.04 | 3,942 | BMX9K07 |
| 0.08% | RLAY | RELAY THERAPEUTICS INC | -- | $70,600.50 | 8,115 | BN2R582 |
| 0.08% | ANAB | ANAPTYSBIO INC | -- | $70,230.24 | 1,296 | BDRW1L7 |
| 0.08% | NVAX | NOVAVAX INC | -- | $70,002.80 | 7,609 | BJDQXG4 |
| 0.08% | NTLA | INTELLIA THERAPEUTICS INC | -- | $68,546.72 | 5,423 | BYZM6C2 |
| 0.08% | QURE | UNIQURE NV | -- | $68,345.31 | 2,917 | BJFSR88 |
| 0.07% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $66,765.24 | 2,043 | BLCD809 |
| 0.07% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $66,600.00 | 1,480 | BX7RSN3 |
| 0.07% | RAPP | RAPPORT THERAPEUTICS INC | -- | $66,424.32 | 2,232 | BR3T9B6 |
| 0.07% | ATAI | ATAIBECKLEY INC | -- | $65,979.40 | 17,005 | BWJDYK1 |
| 0.07% | ARDX | ARDELYX INC | -- | $65,190.21 | 11,377 | BN89V40 |
| 0.07% | ZBIO | ZENAS BIOPHARMA INC | -- | $65,036.44 | 2,513 | BQB42H3 |
| 0.07% | TRVI | TREVI THERAPEUTICS INC | -- | $63,882.56 | 6,004 | BJH9ZN0 |
| 0.07% | KOD | KODIAK SCIENCES INC | -- | $62,795.52 | 2,484 | BFXC933 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $61,396.56 | 2,152 | BNFWZS4 |
| 0.07% | ALVO | ALVOTECH SA | -- | $60,675.84 | 14,656 | BPNTJ34 |
| 0.07% | TSHA | TAYSHA GENE THERAPIES INC | -- | $60,277.50 | 12,825 | BNC1BX1 |
| 0.07% | NVCR | NOVOCURE LTD | -- | $59,560.48 | 5,243 | BYSS4X4 |
| 0.07% | EYPT | EYEPOINT INC | -- | $59,419.08 | 3,876 | BMGS7L1 |
| 0.06% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $57,945.29 | 3,497 | BYP80F1 |
| 0.06% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $57,870.02 | 3,049 | BP7KZP7 |
| 0.06% | SEPN | SEPTERNA INC | -- | $57,178.88 | 2,096 | BQNKXX2 |
| 0.06% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $56,626.46 | 4,807 | BLB0YH0 |
| 0.06% | GERN | GERON CORP | -- | $56,191.32 | 29,889 | 2370381 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $53,692.80 | 5,712 | B8K7T65 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $53,553.84 | 681 | BNSP8K3 |
| 0.06% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $53,344.69 | 18,587 | BF0DMK7 |
| 0.06% | SVRA | SAVARA INC | -- | $52,684.31 | 9,527 | BYXGN81 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $51,353.09 | 7,769 | BLR7H87 |
| 0.06% | ORIC | ORIC PHARMACEUTICALS INC | -- | $50,661.60 | 4,560 | BKVDFF7 |
| 0.06% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $50,635.20 | 959 | BL95N25 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $50,012.72 | 12,472 | BMFJJ97 |
| 0.05% | VIR | VIR BIOTECHNOLOGY INC | -- | $49,245.84 | 6,514 | BK4PZ38 |
| 0.05% | FTRE | FORTREA HOLDINGS INC | -- | $47,586.00 | 4,326 | BRXYZ57 |
| 0.05% | PCRX | PACIRA BIOSCIENCES INC | -- | $46,765.08 | 2,014 | B3X26D8 |
| 0.05% | VTYX | VENTYX BIOSCIENCES INC | -- | $46,673.77 | 3,341 | BMG99Y1 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $46,653.18 | 2,373 | BMNDK09 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $46,185.44 | 2,192 | BZ7PJQ1 |
| 0.05% | GHRS | GH RESEARCH PLC | -- | $45,287.88 | 2,904 | BP6C0S2 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $44,439.67 | 1,933 | BMGTLY5 |
| 0.05% | CTMX | CYTOMX THERAPEUTICS INC | -- | $43,076.19 | 7,933 | BYWVTY5 |
| 0.05% | ABCL | ABCELLERA BIOLOGICS INC | -- | $42,605.60 | 14,015 | BL53SR3 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $41,652.00 | 4,628 | BMCR7V2 |
| 0.04% | OMER | OMEROS CORP | -- | $39,972.80 | 3,320 | B4NB858 |
| 0.04% | CSTL | CASTLE BIOSCIENCES INC | -- | $39,930.07 | 1,367 | BKLCWZ3 |
| 0.04% | BCAX | BICARA THERAPEUTICS INC | -- | $39,706.20 | 2,565 | BQB42F1 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $38,951.64 | 11,193 | BBNBTD2 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $38,756.48 | 2,296 | BQS7491 |
| 0.04% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $38,451.35 | 9,005 | BZ0QMB7 |
| 0.04% | XNCR | XENCOR INC | -- | $38,155.04 | 3,344 | BGCYWN8 |
| 0.04% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $38,040.02 | 3,331 | BJLKVS6 |
| 0.04% | CGEM | CULLINAN THERAPEUTICS INC | -- | $37,755.90 | 2,766 | BM90J52 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $37,469.61 | 2,367 | BD06CS0 |
| 0.04% | JANX | JANUX THERAPEUTICS INC | -- | $36,833.28 | 2,816 | BMFX8Y7 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $36,733.32 | 1,833 | BD9GVY0 |
| 0.04% | ARVN | ARVINAS INC | -- | $36,053.93 | 3,007 | BDZ30Q0 |
| 0.04% | CMPS | COMPASS PATHWAYS PLC | -- | $35,516.60 | 4,412 | BMC3HS7 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $34,466.04 | 4,074 | BYZD465 |
| 0.04% | BIOA | BIOAGE LABS INC | -- | $34,436.29 | 1,679 | BT9K6D8 |
| 0.04% | PSNL | PERSONALIS INC | -- | $34,428.24 | 4,158 | BJQ0608 |
| 0.04% | ANNX | ANNEXON INC | -- | $33,207.30 | 6,777 | BMVV9R5 |
| 0.03% | REPL | REPLIMUNE GROUP INC | -- | $31,734.72 | 3,673 | BDDVW37 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $30,163.32 | 7,617 | B3MZ6K5 |
| 0.03% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $30,141.00 | 850 | BQD3J33 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $28,079.05 | 3,769 | BFYQFJ2 |
| 0.03% | FULC | FULCRUM THERAPEUTICS INC | -- | $27,874.00 | 2,534 | BJDX8Z9 |
| 0.03% | PRME | PRIME MEDICINE INC | -- | $27,638.04 | 8,452 | BPBJFM7 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $26,963.37 | 2,667 | BMFK3H6 |
| 0.03% | NMRA | NEUMORA THERAPEUTICS INC | -- | $26,519.97 | 7,823 | BN4JN37 |
| 0.03% | CRMD | CORMEDIX INC | -- | $25,933.67 | 3,689 | BJ0LT31 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $24,128.50 | 2,675 | BKLXFX5 |
| 0.03% | KMDA | KAMADA LTD | -- | $23,768.80 | 2,701 | B2Q9833 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $23,196.80 | 2,636 | BLFBZ32 |
| 0.03% | KROS | KEROS THERAPEUTICS INC | -- | $23,101.20 | 1,426 | BM7V485 |
| 0.03% | GOSS | GOSSAMER BIO INC | -- | $23,082.81 | 10,837 | BJ0CK86 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $22,862.29 | 677 | B292NQ7 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $22,758.96 | 14,136 | B4N8MH9 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $22,730.40 | 2,520 | B91XRN2 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $22,632.75 | 3,353 | 2107437 |
| 0.02% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $22,562.40 | 5,712 | BYVQJ96 |
| 0.02% | ETON | ETON PHARMACEUTICALS INC | -- | $22,520.08 | 1,256 | BGL0JK3 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $21,570.10 | 10,522 | BFZNYB7 |
| 0.02% | LXEO | LEXEO THERAPEUTICS INC | -- | $21,492.93 | 3,417 | BQ6C357 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $21,400.68 | 4,886 | BFY7DC4 |
| 0.02% | LYEL | LYELL IMMUNOPHARMA INC | -- | $21,250.20 | 993 | BTNMG41 |
| 0.02% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $21,049.00 | 6,790 | BMCWKZ2 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $20,830.08 | 3,648 | BQHN6C7 |
| 0.02% | UPB | UPSTREAM BIO INC | -- | $20,442.40 | 2,530 | BRCFFK6 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $20,209.10 | 1,790 | BP81RK8 |
| 0.02% | IVVD | INVIVYD INC | -- | $20,111.25 | 12,975 | BM8NHS1 |
| 0.02% | PEPG | PEPGEN INC | -- | $20,022.18 | 3,219 | BMTX3D7 |
| 0.02% | RGNX | REGENXBIO INC | -- | $19,291.80 | 2,370 | BZ0G875 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $19,126.80 | 5,060 | BDFKQ07 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $18,720.12 | 876 | BPBPCG8 |
| 0.02% | ABSI | ABSCI CORP | -- | $18,658.65 | 7,041 | BN94K69 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $18,252.01 | 1,351 | B9L5200 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $17,233.96 | 4,183 | BYTYP72 |
| 0.02% | AVIR | ATEA PHARMACEUTICALS INC | -- | $17,009.70 | 3,658 | BLN9Z50 |
| 0.02% | LENZ | LENZ THERAPEUTICS INC | -- | $16,979.35 | 1,465 | BQV0J03 |
| 0.02% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $16,857.56 | 1,082 | BPRBTY7 |
| 0.02% | ACRS | ACLARIS THERAPEUTICS INC | -- | $16,436.52 | 5,073 | BYV2W40 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $16,111.97 | 2,359 | B7F2TY6 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $16,083.93 | 2,973 | BP81R42 |
| 0.02% | NBP | NOVABRIDGE BIOSCIENCES | -- | $16,015.72 | 4,868 | BKRRKY7 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $15,937.92 | 2,767 | B12W3P6 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $15,751.68 | 2,051 | BSMLR16 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $15,684.64 | 9,392 | BFMLGR4 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $15,173.04 | 2,648 | BMF7DT9 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $15,115.00 | 3,023 | BMVBZF5 |
| 0.01% | EOLS | EVOLUS INC | -- | $13,262.95 | 3,035 | BDRJH21 |
| 0.01% | CADL | CANDEL THERAPEUTICS INC | -- | $13,119.85 | 2,570 | BP0TQC5 |
| 0.01% | CABA | CABALETTA BIO INC | -- | $13,115.37 | 4,507 | BK5MWR1 |
| 0.01% | NGNE | NEUROGENE INC | -- | $12,789.00 | 725 | BS2F741 |
| 0.01% | AARD | AARDVARK THERAPEUTICS INC | -- | $12,554.08 | 1,019 | BTXQTX3 |
| 0.01% | LFCR | LIFECORE BIOMEDICAL INC | -- | $12,506.02 | 1,754 | 2517058 |
| 0.01% | LRMR | LARIMAR THERAPEUTICS INC | -- | $11,903.76 | 4,008 | BMXNGZ6 |
| 0.01% | ACIU | AC IMMUNE SA | -- | $11,846.52 | 4,701 | BZC0D70 |
| 0.01% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $11,631.42 | 2,166 | BKDQKM6 |
| 0.01% | OABI | OMNIAB INC | -- | $11,458.00 | 6,740 | BN13S71 |
| 0.01% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $10,995.00 | 2,199 | BL5B6Z1 |
| 0.01% | VOR | VOR BIOPHARMA INC | -- | $10,690.95 | 789 | BRJJYT3 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $10,364.48 | 2,644 | BPRB2N7 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $10,201.10 | 1,330 | BKC9SX3 |
| 0.01% | HUMA | HUMACYTE INC | -- | $9,907.84 | 8,768 | BMYTJP4 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $9,802.08 | 4,538 | BKX9NQ0 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $9,628.91 | 2,759 | BY7RB53 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $9,224.17 | 5,659 | BRK0149 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $8,613.96 | 9,156 | BNR5QT9 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $8,182.09 | 4,571 | BZ8FPH3 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $7,876.80 | 4,376 | BNYJR68 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $7,724.64 | 1,452 | BP2NYN2 |
| 0.01% | MENS | JYONG BIOTECH LTD | -- | $7,155.60 | 3,560 | BPTK6Z2 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $6,216.44 | 2,668 | BKTV702 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $5,891.43 | 4,567 | BNNXX18 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $5,162.36 | 2,506 | BP7L561 |
| 0.01% | CDXS | CODEXIS INC | -- | $4,947.93 | 4,229 | B5LL2C2 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $4,828.06 | 7,796 | BNNXX52 |
| -- | PYXS | PYXIS ONCOLOGY INC | -- | $4,139.30 | 2,915 | BLBR8D5 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $18.42 | 01 | BTFHQP5 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 37,862,131 | -- | 6,332 | -- |
| -- | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 26,399,448 | -- | 4,415 | -- |
| -- | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 20,695,015 | -- | 3,461 | -- |
| -- | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 15,779,874 | -- | 2,639 | -- |
| -- | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,853,053 | -- | 2,484 | -- |
| -- | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,785,017 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $28,208,796.48 | 28,208,796 | -- |
Index
as of 12/31/2025
- Total Number of Companies262
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$7.32 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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