BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 12/31/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 1/29/2026- NAV $84.90
- NAV Change $+0.47
- Market Price $84.89
- Market Price Change $+0.44
- Trading Volume (M) 10,224
- 30-Day Median Bid Ask Spread 0.27%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 1/29/2026- NAV $84.90
- NAV Change $+0.47
- Market Price $84.89
- Market Price Change $+0.44
- Trading Volume (M) 10,224
- 30-Day Median Bid Ask Spread 0.27%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 12/31/2025
Holdings
as of 1/29/2026
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 6.33% | GILD | GILEAD SCIENCES INC | -- | $5,646,611.65 | 40,463 | 2369174 |
| 6.27% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,585,910.24 | 11,743 | 2931034 |
| 5.67% | AMGN | AMGEN INC | -- | $5,054,592.66 | 14,739 | 2023607 |
| 4.07% | REGN | REGENERON PHARMACEUTICALS | -- | $3,624,291.84 | 4,836 | 2730190 |
| 2.41% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,145,242.94 | 6,186 | B00FWN1 |
| 1.77% | INSM | INSMED INC | -- | $1,575,990.52 | 9,986 | 2614487 |
| 1.36% | BIIB | BIOGEN INC | -- | $1,210,180.42 | 6,869 | 2455965 |
| 1.30% | ARGX | ARGENX SE - ADR | -- | $1,155,442.36 | 1,363 | BDVLM39 |
| 1.20% | ILMN | ILLUMINA INC | -- | $1,070,882.26 | 7,154 | 2613990 |
| 1.06% | UTHR | UNITED THERAPEUTICS CORP | -- | $942,883.20 | 2,016 | 2430412 |
| 1.04% | INCY | INCYTE CORP | -- | $929,127.36 | 9,192 | 2471950 |
| 1.00% | RVMD | REVOLUTION MEDICINES INC | -- | $888,906.40 | 9,052 | BL71K91 |
| 0.96% | MRNA | MODERNA INC | -- | $857,163.12 | 18,292 | BGSXTS3 |
| 0.92% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $817,404.30 | 20,005 | BMVP7Y0 |
| 0.88% | MEDP | MEDPACE HOLDINGS INC | -- | $782,259.33 | 1,319 | BDCBC61 |
| 0.80% | ROIV | ROIVANT SCIENCES LTD | -- | $717,059.28 | 32,564 | BMW4NZ9 |
| 0.80% | BBIO | BRIDGEBIO PHARMA INC | -- | $713,640.20 | 9,022 | BK1KWG8 |
| 0.79% | VTRS | VIATRIS INC | -- | $704,838.96 | 53,928 | BMWS3X9 |
| 0.75% | GH | GUARDANT HEALTH INC | -- | $669,287.84 | 6,058 | BFXC911 |
| 0.72% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $643,997.28 | 4,668 | 2623911 |
| 0.72% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $643,856.25 | 2,875 | BV9G6B8 |
| 0.71% | IONS | IONIS PHARMACEUTICALS INC | -- | $636,145.92 | 7,584 | BDJ0LS6 |
| 0.64% | SNY | SANOFI-ADR | -- | $572,418.00 | 12,390 | 2964557 |
| 0.62% | BNTX | BIONTECH SE-ADR | -- | $552,789.18 | 4,734 | BK6H543 |
| 0.60% | SMMT | SUMMIT THERAPEUTICS INC | -- | $536,782.40 | 34,856 | BMTVQS7 |
| 0.60% | EXEL | EXELIXIS INC | -- | $530,783.12 | 12,554 | 2576941 |
| 0.59% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $525,855.47 | 1,063 | BD59BS7 |
| 0.58% | ONC | BEONE MEDICINES LTD-ADR | -- | $515,900.00 | 1,474 | BYYWPW6 |
| 0.58% | TEM | TEMPUS AI INC | -- | $514,049.94 | 8,094 | BSLSJJ0 |
| 0.58% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $512,625.05 | 8,995 | 2437071 |
| 0.57% | RNA | AVIDITY BIOSCIENCES INC | -- | $511,981.35 | 7,055 | BMWHPY1 |
| 0.52% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $466,523.10 | 2,845 | B4Q5ZN4 |
| 0.49% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $439,534.08 | 6,359 | BYQBFJ8 |
| 0.49% | AXSM | AXSOME THERAPEUTICS INC | -- | $437,225.40 | 2,360 | BYZR4X4 |
| 0.45% | HALO | HALOZYME THERAPEUTICS INC | -- | $403,810.04 | 5,506 | 2975098 |
| 0.43% | KRYS | KRYSTAL BIOTECH INC | -- | $379,343.72 | 1,358 | BD6JX35 |
| 0.42% | CYTK | CYTOKINETICS INC | -- | $375,560.00 | 5,725 | BBBSBJ5 |
| 0.41% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $368,021.88 | 1,171 | BQ721R4 |
| 0.39% | NUVL | NUVALENT INC-A | -- | $346,418.26 | 3,382 | BMVBZD3 |
| 0.37% | CAI | CARIS LIFE SCIENCES INC | -- | $332,917.20 | 13,211 | BT18HP9 |
| 0.36% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $324,062.50 | 3,125 | BF2YWG4 |
| 0.36% | PCVX | VAXCYTE INC | -- | $323,733.78 | 6,129 | BKPVGH6 |
| 0.35% | ABVX | ABIVAX SA-ADR | -- | $313,824.56 | 2,764 | BLC89B2 |
| 0.32% | PTCT | PTC THERAPEUTICS INC | -- | $287,300.37 | 3,759 | B17VCN9 |
| 0.31% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $272,692.35 | 3,129 | BQS9486 |
| 0.31% | IBRX | IMMUNITYBIO INC | -- | $272,557.38 | 46,118 | BNSP0B8 |
| 0.30% | COGT | COGENT BIOSCIENCES INC | -- | $270,590.55 | 7,187 | BLR6XK8 |
| 0.30% | ALKS | ALKERMES PLC | -- | $269,657.28 | 7,731 | B3P6D26 |
| 0.28% | KYMR | KYMERA THERAPEUTICS INC | -- | $249,002.79 | 3,369 | BMPRZV5 |
| 0.28% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $247,625.52 | 2,406 | BJDX8Y8 |
| 0.27% | CRSP | CRISPR THERAPEUTICS AG | -- | $238,047.70 | 4,462 | BDHF4K6 |
| 0.26% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $233,369.71 | 2,927 | BDCBCD8 |
| 0.26% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $230,502.84 | 4,443 | BDD19F8 |
| 0.24% | IMVT | IMMUNOVANT INC | -- | $217,075.15 | 8,207 | BJRFSB7 |
| 0.24% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $214,537.92 | 4,776 | BFZQ0L8 |
| 0.23% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $207,685.09 | 14,719 | BFNF1D6 |
| 0.23% | FOLD | AMICUS THERAPEUTICS INC | -- | $206,144.42 | 14,446 | B19FQ48 |
| 0.23% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $203,569.70 | 7,921 | 2713317 |
| 0.23% | -- | INDIVIOR PHARMACEUTICALS INC COMMON STOCK USD 0.001 | -- | $202,845.24 | 5,844 | -- |
| 0.23% | CGON | CG ONCOLOGY INC | -- | $201,767.34 | 3,777 | BRBCSP4 |
| 0.21% | ADMA | ADMA BIOLOGICS INC | -- | $189,559.44 | 11,144 | B9NSBM2 |
| 0.21% | ACLX | ARCELLX INC | -- | $184,779.82 | 2,707 | BPCJ1Q2 |
| 0.21% | GRAL | GRAIL INC | -- | $184,288.50 | 1,825 | BSLSSX7 |
| 0.20% | LGND | LIGAND PHARMACEUTICALS | -- | $179,946.74 | 922 | 2501578 |
| 0.20% | APGE | APOGEE THERAPEUTICS INC | -- | $179,638.66 | 2,567 | BM9HHL5 |
| 0.19% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $166,914.96 | 5,309 | BP8JSP4 |
| 0.17% | XENE | XENON PHARMACEUTICALS INC | -- | $151,087.68 | 3,618 | BRJ3GY4 |
| 0.17% | DNLI | DENALI THERAPEUTICS INC | -- | $148,258.53 | 6,867 | BD2B4V0 |
| 0.17% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $147,561.55 | 5,735 | BKX9VD3 |
| 0.16% | TERN | TERNS PHARMACEUTICALS INC | -- | $144,255.60 | 4,218 | BMDJ0C9 |
| 0.16% | VCYT | VERACYTE INC | -- | $143,376.74 | 3,701 | BFTWZY0 |
| 0.16% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $142,662.46 | 4,957 | BKY5JZ8 |
| 0.16% | BEAM | BEAM THERAPEUTICS INC | -- | $139,156.79 | 4,751 | BK6L288 |
| 0.16% | IRON | DISC MEDICINE INC | -- | $138,876.40 | 1,768 | BMGJZJ8 |
| 0.15% | ERAS | ERASCA INC | -- | $136,958.04 | 13,284 | BNLYBF3 |
| 0.15% | APLS | APELLIS PHARMACEUTICALS INC | -- | $136,479.05 | 5,921 | BYTQ6X1 |
| 0.15% | IDYA | IDEAYA BIOSCIENCES INC | -- | $135,423.95 | 4,105 | BK0VHF6 |
| 0.15% | VERA | VERA THERAPEUTICS INC | -- | $134,595.00 | 2,991 | BL55460 |
| 0.15% | TVTX | TRAVERE THERAPEUTICS INC | -- | $134,006.11 | 4,189 | BLFGJD5 |
| 0.15% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $131,726.10 | 2,685 | B72ZBG4 |
| 0.15% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $131,308.76 | 7,148 | BJ5FZ74 |
| 0.15% | TARS | TARSUS PHARMACEUTICALS INC | -- | $130,631.48 | 1,988 | BMH5RL1 |
| 0.14% | ALMS | ALUMIS INC | -- | $122,175.68 | 4,552 | BPLQG36 |
| 0.14% | SYRE | SPYRE THERAPEUTICS INC | -- | $121,996.14 | 3,633 | BQBBDY8 |
| 0.13% | DYN | DYNE THERAPEUTICS INC | -- | $119,563.56 | 6,687 | BN15WD1 |
| 0.13% | TWST | TWIST BIOSCIENCE CORP | -- | $119,043.54 | 2,863 | BGKG6G7 |
| 0.13% | MLYS | MINERALYS THERAPEUTICS INC | -- | $118,893.45 | 3,705 | BP9N0G0 |
| 0.13% | TXG | 10X GENOMICS INC-CLASS A | -- | $113,443.20 | 5,454 | BKS3RS7 |
| 0.13% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $112,428.13 | 4,517 | BLB0YQ9 |
| 0.12% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $109,627.59 | 4,517 | BJ62Z18 |
| 0.12% | SRPT | SAREPTA THERAPEUTICS INC | -- | $104,178.91 | 4,906 | B8DPDT7 |
| 0.12% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $104,004.00 | 24,075 | BM9FJ13 |
| 0.11% | WVE | WAVE LIFE SCIENCES LTD | -- | $101,881.31 | 7,831 | BYZG9R0 |
| 0.11% | MAZE | MAZE THERAPEUTICS INC | -- | $101,385.00 | 2,253 | BSRK699 |
| 0.11% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $99,411.42 | 2,697 | BKSGZN7 |
| 0.11% | OCUL | OCULAR THERAPEUTIX INC | -- | $99,251.25 | 9,975 | BNZB1X8 |
| 0.11% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $95,978.98 | 3,683 | BMZ4LN0 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $92,975.40 | 2,115 | BRXB0C0 |
| 0.10% | GMAB | GENMAB A/S -SP ADR | -- | $91,278.95 | 2,737 | BBC9WC7 |
| 0.10% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $90,434.45 | 6,173 | BFWLC09 |
| 0.10% | ARDX | ARDELYX INC | -- | $89,309.45 | 11,377 | BN89V40 |
| 0.10% | SION | SIONNA THERAPEUTICS INC | -- | $88,699.60 | 2,090 | BQKXDX4 |
| 0.10% | VCEL | VERICEL CORP | -- | $86,432.00 | 2,368 | BSBMN89 |
| 0.10% | ANIP | ANI PHARMACEUTICALS INC | -- | $86,264.00 | 1,052 | BCDWBX6 |
| 0.10% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $85,109.04 | 5,498 | BRJZSK0 |
| 0.09% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $83,801.30 | 4,070 | BN7Q7R7 |
| 0.09% | NRIX | NURIX THERAPEUTICS INC | -- | $83,482.14 | 4,746 | BMVLGP2 |
| 0.09% | PHVS | PHARVARIS NV | -- | $83,342.21 | 2,999 | BMZ2X38 |
| 0.09% | MNKD | MANNKIND CORP | -- | $83,248.62 | 14,378 | BF081J4 |
| 0.09% | STOK | STOKE THERAPEUTICS INC | -- | $83,112.25 | 2,675 | BJQ05Z6 |
| 0.09% | TYRA | TYRA BIOSCIENCES INC | -- | $80,817.66 | 2,499 | BMVNDH9 |
| 0.09% | ORKA | ORUKA THERAPEUTICS INC | -- | $79,934.42 | 2,267 | BKVF0J2 |
| 0.09% | -- | DEFINIUM THERAPEUTICS INC COMMON STOCK USD 0 | -- | $79,510.88 | 4,612 | -- |
| 0.09% | ALVO | ALVOTECH SA | -- | $79,435.52 | 14,656 | BPNTJ34 |
| 0.09% | ZYME | ZYMEWORKS INC | -- | $78,419.52 | 3,504 | BPCQZY9 |
| 0.09% | UPB | UPSTREAM BIO INC | -- | $78,278.20 | 2,530 | BRCFFK6 |
| 0.09% | MBX | MBX BIOSCIENCES INC | -- | $77,437.68 | 2,102 | BQXJKH2 |
| 0.09% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $76,358.70 | 5,142 | BPCK358 |
| 0.08% | NTLA | INTELLIA THERAPEUTICS INC | -- | $75,379.70 | 5,423 | BYZM6C2 |
| 0.08% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $75,375.30 | 2,730 | BCBVTX1 |
| 0.08% | PGEN | PRECIGEN INC | -- | $75,048.51 | 16,567 | BKM5C84 |
| 0.08% | RAPT | RAPT THERAPEUTICS INC | -- | $74,746.11 | 1,297 | BTJZB49 |
| 0.08% | FTRE | FORTREA HOLDINGS INC | -- | $73,758.30 | 4,326 | BRXYZ57 |
| 0.08% | TNGX | TANGO THERAPEUTICS INC | -- | $73,591.02 | 6,306 | BP2P6L0 |
| 0.08% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $73,227.18 | 3,497 | BYP80F1 |
| 0.08% | HROW | HARROW INC | -- | $72,706.62 | 1,734 | BHNDW86 |
| 0.08% | NVAX | NOVAVAX INC | -- | $71,828.96 | 7,609 | BJDQXG4 |
| 0.08% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $71,336.93 | 2,779 | BMFD115 |
| 0.08% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $69,852.24 | 3,942 | BMX9K07 |
| 0.08% | INVA | INNOVIVA INC | -- | $69,144.75 | 3,501 | BDDXF67 |
| 0.08% | QURE | UNIQURE NV | -- | $69,001.64 | 2,917 | BJFSR88 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $67,419.00 | 2,043 | BLCD809 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $67,118.00 | 1,480 | BX7RSN3 |
| 0.07% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $65,752.86 | 9,858 | 2100362 |
| 0.07% | ATAI | ATAIBECKLEY INC | -- | $65,299.20 | 17,005 | BWJDYK1 |
| 0.07% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $65,126.64 | 3,049 | BP7KZP7 |
| 0.07% | NVCR | NOVOCURE LTD | -- | $64,908.34 | 5,243 | BYSS4X4 |
| 0.07% | TRVI | TREVI THERAPEUTICS INC | -- | $64,182.76 | 6,004 | BJH9ZN0 |
| 0.07% | KOD | KODIAK SCIENCES INC | -- | $63,168.12 | 2,484 | BFXC933 |
| 0.07% | RLAY | RELAY THERAPEUTICS INC | -- | $62,566.65 | 8,115 | BN2R582 |
| 0.07% | ANAB | ANAPTYSBIO INC | -- | $62,013.60 | 1,296 | BDRW1L7 |
| 0.07% | RAPP | RAPPORT THERAPEUTICS INC | -- | $59,706.00 | 2,232 | BR3T9B6 |
| 0.07% | TSHA | TAYSHA GENE THERAPIES INC | -- | $58,610.25 | 12,825 | BNC1BX1 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $57,371.20 | 12,472 | BMFJJ97 |
| 0.06% | EYPT | EYEPOINT INC | -- | $57,171.00 | 3,876 | BMGS7L1 |
| 0.06% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $56,274.80 | 2,152 | BNFWZS4 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $56,247.56 | 7,769 | BLR7H87 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $54,097.90 | 14,015 | BL53SR3 |
| 0.06% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $53,646.12 | 4,807 | BLB0YH0 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $53,531.72 | 1,367 | BKLCWZ3 |
| 0.06% | SVRA | SAVARA INC | -- | $53,160.66 | 9,527 | BYXGN81 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $53,064.48 | 5,712 | B8K7T65 |
| 0.06% | ZBIO | ZENAS BIOPHARMA INC | -- | $52,471.44 | 2,513 | BQB42H3 |
| 0.06% | VIR | VIR BIOTECHNOLOGY INC | -- | $50,678.92 | 6,514 | BK4PZ38 |
| 0.06% | SEPN | SEPTERNA INC | -- | $49,884.80 | 2,096 | BQNKXX2 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $49,413.36 | 681 | BNSP8K3 |
| 0.06% | ORIC | ORIC PHARMACEUTICALS INC | -- | $49,065.60 | 4,560 | BKVDFF7 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $48,883.81 | 18,587 | BF0DMK7 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $47,298.16 | 4,628 | BMCR7V2 |
| 0.05% | GHRS | GH RESEARCH PLC | -- | $47,160.96 | 2,904 | BP6C0S2 |
| 0.05% | VTYX | VENTYX BIOSCIENCES INC | -- | $46,606.95 | 3,341 | BMG99Y1 |
| 0.05% | CTMX | CYTOMX THERAPEUTICS INC | -- | $45,535.42 | 7,933 | BYWVTY5 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $45,514.14 | 2,373 | BMNDK09 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $45,352.48 | 2,192 | BZ7PJQ1 |
| 0.05% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $45,068.43 | 3,331 | BJLKVS6 |
| 0.05% | ANNX | ANNEXON INC | -- | $44,186.04 | 6,777 | BMVV9R5 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $43,492.50 | 1,933 | BMGTLY5 |
| 0.05% | BCAX | BICARA THERAPEUTICS INC | -- | $43,374.15 | 2,565 | BQB42F1 |
| 0.05% | PSNL | PERSONALIS INC | -- | $41,455.26 | 4,158 | BJQ0608 |
| 0.05% | XNCR | XENCOR INC | -- | $41,398.72 | 3,344 | BGCYWN8 |
| 0.05% | MESO | MESOBLAST LTD- SPON ADR | -- | $41,236.16 | 2,296 | BQS7491 |
| 0.05% | GERN | GERON CORP | -- | $40,947.93 | 29,889 | 2370381 |
| 0.05% | PCRX | PACIRA BIOSCIENCES INC | -- | $40,461.26 | 2,014 | B3X26D8 |
| 0.05% | ARVN | ARVINAS INC | -- | $40,233.66 | 3,007 | BDZ30Q0 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $39,735.15 | 11,193 | BBNBTD2 |
| 0.04% | OMER | OMEROS CORP | -- | $39,674.00 | 3,320 | B4NB858 |
| 0.04% | JANX | JANUX THERAPEUTICS INC | -- | $38,945.28 | 2,816 | BMFX8Y7 |
| 0.04% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $38,254.51 | 959 | BL95N25 |
| 0.04% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $37,190.65 | 9,005 | BZ0QMB7 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $37,043.55 | 2,367 | BD06CS0 |
| 0.04% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $37,018.62 | 7,617 | B3MZ6K5 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $35,075.80 | 8,452 | BPBJFM7 |
| 0.04% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $33,502.32 | 14,136 | B4N8MH9 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $33,488.28 | 4,074 | BYZD465 |
| 0.04% | CGEM | CULLINAN THERAPEUTICS INC | -- | $32,970.72 | 2,766 | BM90J52 |
| 0.04% | BIOA | BIOAGE LABS INC | -- | $32,068.90 | 1,679 | BT9K6D8 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $31,619.25 | 1,833 | BD9GVY0 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $29,957.48 | 4,412 | BMC3HS7 |
| 0.03% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $29,886.00 | 850 | BQD3J33 |
| 0.03% | CRMD | CORMEDIX INC | -- | $29,585.78 | 3,689 | BJ0LT31 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $29,172.06 | 3,769 | BFYQFJ2 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $28,190.19 | 2,667 | BMFK3H6 |
| 0.03% | FULC | FULCRUM THERAPEUTICS INC | -- | $27,721.96 | 2,534 | BJDX8Z9 |
| 0.03% | RGNX | REGENXBIO INC | -- | $27,492.00 | 2,370 | BZ0G875 |
| 0.03% | REPL | REPLIMUNE GROUP INC | -- | $27,143.47 | 3,673 | BDDVW37 |
| 0.03% | GOSS | GOSSAMER BIO INC | -- | $26,225.54 | 10,837 | BJ0CK86 |
| 0.03% | LENZ | LENZ THERAPEUTICS INC | -- | $26,047.70 | 1,465 | BQV0J03 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $25,866.69 | 3,417 | BQ6C357 |
| 0.03% | KROS | KEROS THERAPEUTICS INC | -- | $25,653.74 | 1,426 | BM7V485 |
| 0.03% | ALT | ALTIMMUNE INC | -- | $24,918.60 | 4,886 | BFY7DC4 |
| 0.03% | LYEL | LYELL IMMUNOPHARMA INC | -- | $24,636.33 | 993 | BTNMG41 |
| 0.03% | SLDB | SOLID BIOSCIENCES INC | -- | $24,076.80 | 3,648 | BQHN6C7 |
| 0.03% | IVVD | INVIVYD INC | -- | $24,003.75 | 12,975 | BM8NHS1 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $23,994.75 | 2,675 | BKLXFX5 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $23,354.96 | 2,636 | BLFBZ32 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $23,289.70 | 6,790 | BMCWKZ2 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $23,106.01 | 677 | B292NQ7 |
| 0.03% | SIGA | SIGA TECHNOLOGIES INC | -- | $22,833.93 | 3,353 | 2107437 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $22,831.20 | 2,520 | B91XRN2 |
| 0.03% | KMDA | KAMADA LTD | -- | $22,607.37 | 2,701 | B2Q9833 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $21,527.26 | 2,767 | B12W3P6 |
| 0.02% | ABSI | ABSCI CORP | -- | $21,334.23 | 7,041 | BN94K69 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $20,871.40 | 1,790 | BP81RK8 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $20,538.53 | 4,183 | BYTYP72 |
| 0.02% | ETON | ETON PHARMACEUTICALS INC | -- | $19,154.00 | 1,256 | BGL0JK3 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $18,124.44 | 876 | BPBPCG8 |
| 0.02% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $18,049.92 | 5,712 | BYVQJ96 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $17,963.00 | 5,060 | BDFKQ07 |
| 0.02% | NBP | NOVABRIDGE BIOSCIENCES | -- | $17,914.24 | 4,868 | BKRRKY7 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $17,427.90 | 1,351 | B9L5200 |
| 0.02% | ACRS | ACLARIS THERAPEUTICS INC | -- | $17,400.39 | 5,073 | BYV2W40 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $16,838.71 | 2,051 | BSMLR16 |
| 0.02% | PEPG | PEPGEN INC | -- | $16,803.18 | 3,219 | BMTX3D7 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $16,729.98 | 10,522 | BFZNYB7 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $16,292.04 | 2,973 | BP81R42 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $16,037.15 | 7,823 | BN4JN37 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $15,983.40 | 4,701 | BZC0D70 |
| 0.02% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $15,797.20 | 1,082 | BPRBTY7 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $15,278.96 | 2,648 | BMF7DT9 |
| 0.02% | CADL | CANDEL THERAPEUTICS INC | -- | $15,240.10 | 2,570 | BP0TQC5 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $15,168.37 | 2,359 | B7F2TY6 |
| 0.02% | LFCR | LIFECORE BIOMEDICAL INC | -- | $14,926.54 | 1,754 | 2517058 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $14,722.01 | 3,023 | BMVBZF5 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $14,308.56 | 4,008 | BMXNGZ6 |
| 0.02% | AVIR | ATEA PHARMACEUTICALS INC | -- | $14,302.78 | 3,658 | BLN9Z50 |
| 0.02% | EOLS | EVOLUS INC | -- | $14,143.10 | 3,035 | BDRJH21 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $14,122.32 | 2,166 | BKDQKM6 |
| 0.02% | NGNE | NEUROGENE INC | -- | $13,695.25 | 725 | BS2F741 |
| 0.02% | AARD | AARDVARK THERAPEUTICS INC | -- | $13,603.65 | 1,019 | BTXQTX3 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $13,430.56 | 9,392 | BFMLGR4 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $13,185.47 | 5,659 | BRK0149 |
| 0.01% | OABI | OMNIAB INC | -- | $12,536.40 | 6,740 | BN13S71 |
| 0.01% | CABA | CABALETTA BIO INC | -- | $12,394.25 | 4,507 | BK5MWR1 |
| 0.01% | VOR | VOR BIOPHARMA INC | -- | $11,038.11 | 789 | BRJJYT3 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $10,980.82 | 2,759 | BY7RB53 |
| 0.01% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $10,907.04 | 2,199 | BL5B6Z1 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $10,712.52 | 9,156 | BNR5QT9 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $10,068.10 | 1,330 | BKC9SX3 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $9,862.12 | 2,644 | BPRB2N7 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $9,416.26 | 4,571 | BZ8FPH3 |
| 0.01% | MENS | JYONG BIOTECH LTD | -- | $9,113.60 | 3,560 | BPTK6Z2 |
| 0.01% | HUMA | HUMACYTE INC | -- | $9,031.04 | 8,768 | BMYTJP4 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $8,894.48 | 4,538 | BKX9NQ0 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $7,782.72 | 1,452 | BP2NYN2 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $7,117.04 | 2,506 | BP7L561 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $7,016.84 | 2,668 | BKTV702 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $6,476.48 | 4,376 | BNYJR68 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $6,158.84 | 7,796 | BNNXX52 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $5,845.76 | 4,567 | BNNXX18 |
| 0.01% | CDXS | CODEXIS INC | -- | $5,497.70 | 4,229 | B5LL2C2 |
| 0.01% | PYXS | PYXIS ONCOLOGY INC | -- | $4,547.40 | 2,915 | BLBR8D5 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $14.92 | 01 | BTFHQP5 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| 39.23% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 34,973,558 | -- | 5,916 | -- |
| 29.28% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 26,100,111 | -- | 4,415 | -- |
| 23.50% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 20,945,118 | -- | 3,543 | -- |
| 17.50% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 15,600,950 | -- | 2,639 | -- |
| 16.47% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,684,638 | -- | 2,484 | -- |
| 4.20% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,742,100 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $27,152,691.76 | 27,152,692 | -- |
Index
as of 12/31/2025
- Total Number of Companies262
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$7.32 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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