BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 10/31/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 20.05% | 41.93% | 51.59% | 42.58% | 20.67% | 9.55% | 2.60% | 0.91% | 15.79% | 04/07/2010 |
| BIB Market Price | 20.06% | 42.12% | 51.73% | 42.51% | 20.92% | 9.51% | 2.55% | 0.91% | 15.79% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 11/18/2025- NAV $77.81
- NAV Change $+1.10
- Market Price $77.91
- Market Price Change $+1.17
- Trading Volume (M) 21,385
- 30-Day Median Bid Ask Spread 0.29%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 11/18/2025- NAV $77.81
- NAV Change $+1.10
- Market Price $77.91
- Market Price Change $+1.17
- Trading Volume (M) 21,385
- 30-Day Median Bid Ask Spread 0.29%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 11/18/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.27% | AMGN | AMGEN INC | -- | $4,342,529.76 | 12,624 | 2023607 |
| 4.96% | GILD | GILEAD SCIENCES INC | -- | $4,089,981.62 | 32,159 | 2369174 |
| 4.91% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $4,046,851.84 | 9,292 | 2931034 |
| 3.99% | REGN | REGENERON PHARMACEUTICALS | -- | $3,290,142.24 | 4,536 | 2730190 |
| 3.20% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,638,808.40 | 5,708 | B00FWN1 |
| 2.47% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $2,035,740.15 | 22,733 | 2989044 |
| 2.27% | INSM | INSMED INC | -- | $1,871,436.84 | 9,282 | 2614487 |
| 1.49% | ARGX | ARGENX SE - ADR | -- | $1,231,748.73 | 1,341 | BDVLM39 |
| 1.32% | BIIB | BIOGEN INC | -- | $1,086,927.54 | 6,438 | 2455965 |
| 1.15% | UTHR | UNITED THERAPEUTICS CORP | -- | $946,031.15 | 1,985 | 2430412 |
| 1.08% | INCY | INCYTE CORP | -- | $890,648.97 | 8,573 | 2471950 |
| 1.00% | ILMN | ILLUMINA INC | -- | $822,931.59 | 6,747 | 2613990 |
| 0.91% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $748,871.88 | 18,978 | BMVP7Y0 |
| 0.88% | MEDP | MEDPACE HOLDINGS INC | -- | $728,872.30 | 1,235 | BDCBC61 |
| 0.75% | ROIV | ROIVANT SCIENCES LTD | -- | $615,148.56 | 29,978 | BMW4NZ9 |
| 0.73% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $603,179.13 | 4,351 | 2623911 |
| 0.72% | SNY | SANOFI-ADR | -- | $596,825.46 | 11,781 | 2964557 |
| 0.70% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $579,302.84 | 2,668 | BV9G6B8 |
| 0.70% | RVMD | REVOLUTION MEDICINES INC | -- | $579,179.48 | 8,206 | BL71K91 |
| 0.67% | BBIO | BRIDGEBIO PHARMA INC | -- | $550,168.92 | 8,388 | BK1KWG8 |
| 0.66% | SMMT | SUMMIT THERAPEUTICS INC | -- | $548,190.91 | 32,611 | BMTVQS7 |
| 0.66% | VTRS | VIATRIS INC | -- | $548,116.38 | 51,178 | BMWS3X9 |
| 0.66% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $545,574.24 | 976 | BD59BS7 |
| 0.65% | ONC | BEONE MEDICINES LTD-ADR | -- | $536,782.00 | 1,475 | BYYWPW6 |
| 0.63% | GH | GUARDANT HEALTH INC | -- | $523,436.89 | 5,477 | BFXC911 |
| 0.63% | IONS | IONIS PHARMACEUTICALS INC | -- | $520,978.50 | 6,993 | BDJ0LS6 |
| 0.61% | EXEL | EXELIXIS INC | -- | $503,952.40 | 11,816 | 2576941 |
| 0.60% | TEM | TEMPUS AI INC | -- | $494,431.85 | 7,405 | BSLSJJ0 |
| 0.58% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $480,183.20 | 2,660 | B4Q5ZN4 |
| 0.55% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $456,514.64 | 8,429 | 2437071 |
| 0.55% | BNTX | BIONTECH SE-ADR | -- | $452,567.42 | 4,414 | BK6H543 |
| 0.52% | MRNA | MODERNA INC | -- | $425,633.60 | 17,080 | BGSXTS3 |
| 0.49% | RNA | AVIDITY BIOSCIENCES INC | -- | $400,089.95 | 5,647 | BMWHPY1 |
| 0.44% | HALO | HALOZYME THERAPEUTICS INC | -- | $359,893.40 | 5,134 | 2975098 |
| 0.42% | CYTK | CYTOKINETICS INC | -- | $347,670.80 | 5,255 | BBBSBJ5 |
| 0.39% | AXSM | AXSOME THERAPEUTICS INC | -- | $323,276.16 | 2,192 | BYZR4X4 |
| 0.39% | MRUS | MERUS NV | -- | $317,864.40 | 3,318 | BZBY005 |
| 0.37% | NUVL | NUVALENT INC-A | -- | $305,110.48 | 2,927 | BMVBZD3 |
| 0.36% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $293,288.18 | 2,918 | BF2YWG4 |
| 0.34% | PCVX | VAXCYTE INC | -- | $282,321.00 | 5,700 | BKPVGH6 |
| 0.32% | PTCT | PTC THERAPEUTICS INC | -- | $267,724.79 | 3,491 | B17VCN9 |
| 0.31% | KRYS | KRYSTAL BIOTECH INC | -- | $259,610.32 | 1,268 | BD6JX35 |
| 0.30% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $245,693.37 | 6,071 | BYQBFJ8 |
| 0.28% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $230,300.31 | 2,729 | BDCBCD8 |
| 0.27% | ACLX | ARCELLX INC | -- | $218,945.67 | 2,433 | BPCJ1Q2 |
| 0.26% | CRSP | CRISPR THERAPEUTICS AG | -- | $213,291.83 | 3,989 | BDHF4K6 |
| 0.26% | ALKS | ALKERMES PLC | -- | $212,076.48 | 7,248 | B3P6D26 |
| 0.25% | COGT | COGENT BIOSCIENCES INC | -- | $204,909.00 | 6,135 | BLR6XK8 |
| 0.24% | KYMR | KYMERA THERAPEUTICS INC | -- | $201,933.40 | 3,140 | BMPRZV5 |
| 0.23% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $192,254.31 | 4,941 | BP8JSP4 |
| 0.23% | AKRO | AKERO THERAPEUTICS INC | -- | $190,806.96 | 3,512 | BK7Y2V9 |
| 0.22% | IMVT | IMMUNOVANT INC | -- | $181,204.81 | 7,649 | BJRFSB7 |
| 0.22% | LGND | LIGAND PHARMACEUTICALS | -- | $178,477.10 | 862 | 2501578 |
| 0.22% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $177,674.31 | 4,131 | BDD19F8 |
| 0.21% | INDV | INDIVIOR PLC | -- | $176,752.54 | 5,479 | BP0BQQ5 |
| 0.21% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $176,262.80 | 7,406 | 2713317 |
| 0.21% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $170,688.51 | 927 | BQ721R4 |
| 0.20% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $168,096.52 | 4,223 | BFZQ0L8 |
| 0.20% | ADMA | ADMA BIOLOGICS INC | -- | $164,368.44 | 10,476 | B9NSBM2 |
| 0.19% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $159,515.59 | 13,787 | BFNF1D6 |
| 0.19% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $159,178.95 | 2,205 | BJDX8Y8 |
| 0.17% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $143,629.20 | 5,265 | BKX9VD3 |
| 0.17% | CGON | CG ONCOLOGY INC | -- | $142,542.50 | 3,350 | BRBCSP4 |
| 0.17% | TARS | TARSUS PHARMACEUTICALS INC | -- | $142,471.47 | 1,851 | BMH5RL1 |
| 0.17% | TVTX | TRAVERE THERAPEUTICS INC | -- | $140,760.00 | 3,910 | BLFGJD5 |
| 0.17% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $138,969.39 | 4,233 | BJ62Z18 |
| 0.17% | XENE | XENON PHARMACEUTICALS INC | -- | $137,383.63 | 3,383 | BRJ3GY4 |
| 0.17% | IRON | DISC MEDICINE INC | -- | $137,122.72 | 1,528 | BMGJZJ8 |
| 0.16% | VCYT | VERACYTE INC | -- | $133,838.28 | 3,453 | BFTWZY0 |
| 0.16% | DYN | DYNE THERAPEUTICS INC | -- | $130,874.24 | 6,244 | BN15WD1 |
| 0.16% | FOLD | AMICUS THERAPEUTICS INC | -- | $129,791.06 | 13,534 | B19FQ48 |
| 0.16% | IDYA | IDEAYA BIOSCIENCES INC | -- | $129,581.24 | 3,844 | BK0VHF6 |
| 0.16% | APGE | APOGEE THERAPEUTICS INC | -- | $129,545.57 | 2,027 | BM9HHL5 |
| 0.16% | GRAL | GRAIL INC | -- | $129,195.56 | 1,586 | BSLSSX7 |
| 0.15% | MLYS | MINERALYS THERAPEUTICS INC | -- | $126,395.07 | 2,913 | BP9N0G0 |
| 0.14% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $119,338.88 | 4,208 | BLB0YQ9 |
| 0.14% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $116,090.48 | 2,552 | BCBVTX1 |
| 0.14% | DNLI | DENALI THERAPEUTICS INC | -- | $112,256.56 | 6,422 | BD2B4V0 |
| 0.13% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $110,678.50 | 2,465 | B72ZBG4 |
| 0.13% | APLS | APELLIS PHARMACEUTICALS INC | -- | $109,442.31 | 5,547 | BYTQ6X1 |
| 0.13% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $108,648.06 | 3,693 | BMX9K07 |
| 0.13% | TERN | TERNS PHARMACEUTICALS INC | -- | $105,775.28 | 3,838 | BMDJ0C9 |
| 0.12% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $102,467.84 | 4,624 | BKY5JZ8 |
| 0.12% | AVDL | AVADEL PHARMACEUTICALS | -- | $97,747.34 | 4,261 | BDGMC59 |
| 0.12% | BEAM | BEAM THERAPEUTICS INC | -- | $97,412.48 | 4,444 | BK6L288 |
| 0.11% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $91,891.25 | 6,683 | BJ5FZ74 |
| 0.11% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $90,321.00 | 2,618 | BQS9486 |
| 0.11% | OCUL | OCULAR THERAPEUTIX INC | -- | $89,811.12 | 7,637 | BNZB1X8 |
| 0.11% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $89,590.00 | 5,780 | BFWLC09 |
| 0.11% | IBRX | IMMUNITYBIO INC | -- | $87,139.50 | 41,495 | BNSP0B8 |
| 0.10% | VCEL | VERICEL CORP | -- | $86,373.39 | 2,213 | BSBMN89 |
| 0.10% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $85,722.78 | 2,522 | BKSGZN7 |
| 0.10% | VERA | VERA THERAPEUTICS INC | -- | $80,948.00 | 2,800 | BL55460 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $78,762.24 | 1,908 | BRXB0C0 |
| 0.09% | TXG | 10X GENOMICS INC-CLASS A | -- | $78,204.56 | 5,026 | BKS3RS7 |
| 0.09% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $78,037.44 | 18,759 | BM9FJ13 |
| 0.09% | ANIP | ANI PHARMACEUTICALS INC | -- | $77,178.64 | 952 | BCDWBX6 |
| 0.09% | JANX | JANUX THERAPEUTICS INC | -- | $76,554.76 | 2,638 | BMFX8Y7 |
| 0.09% | ZYME | ZYMEWORKS INC | -- | $75,867.00 | 3,300 | BPCQZY9 |
| 0.09% | SRPT | SAREPTA THERAPEUTICS INC | -- | $74,869.92 | 4,293 | B8DPDT7 |
| 0.09% | QURE | UNIQURE NV | -- | $71,749.65 | 2,415 | BJFSR88 |
| 0.09% | ALVO | ALVOTECH SA | -- | $70,196.07 | 13,737 | BPNTJ34 |
| 0.08% | STOK | STOKE THERAPEUTICS INC | -- | $69,610.44 | 2,407 | BJQ05Z6 |
| 0.08% | TWST | TWIST BIOSCIENCE CORP | -- | $68,874.00 | 2,649 | BGKG6G7 |
| 0.08% | MNKD | MANNKIND CORP | -- | $68,163.26 | 13,471 | BF081J4 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $66,909.48 | 1,758 | BLCD809 |
| 0.08% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $64,685.65 | 3,785 | BN7Q7R7 |
| 0.08% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $64,519.00 | 9,217 | 2100362 |
| 0.08% | HROW | HARROW INC | -- | $64,481.79 | 1,623 | BHNDW86 |
| 0.08% | SYRE | SPYRE THERAPEUTICS INC | -- | $63,865.00 | 2,650 | BQBBDY8 |
| 0.08% | PGEN | PRECIGEN INC | -- | $63,423.45 | 13,077 | BKM5C84 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $62,750.56 | 1,384 | BX7RSN3 |
| 0.07% | ARDX | ARDELYX INC | -- | $61,446.56 | 10,576 | BN89V40 |
| 0.07% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $60,661.68 | 3,012 | BMZ4LN0 |
| 0.07% | INVA | INNOVIVA INC | -- | $60,558.03 | 2,769 | BDDXF67 |
| 0.07% | TRVI | TREVI THERAPEUTICS INC | -- | $60,463.26 | 5,346 | BJH9ZN0 |
| 0.07% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $58,666.23 | 2,597 | BMFD115 |
| 0.07% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $57,789.58 | 5,146 | BRJZSK0 |
| 0.07% | NVCR | NOVOCURE LTD | -- | $56,196.60 | 4,908 | BYSS4X4 |
| 0.07% | GMAB | GENMAB A/S -SP ADR | -- | $55,788.80 | 1,840 | BBC9WC7 |
| 0.07% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $54,558.45 | 3,911 | BPCK358 |
| 0.06% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $52,861.90 | 2,041 | BNFWZS4 |
| 0.06% | CVAC | CUREVAC NV | -- | $51,698.55 | 9,885 | BN4RD42 |
| 0.06% | ORIC | ORIC PHARMACEUTICALS INC | -- | $50,717.80 | 4,262 | BKVDFF7 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $50,204.28 | 7,091 | BLR7H87 |
| 0.06% | XNCR | XENCOR INC | -- | $50,190.66 | 3,133 | BGCYWN8 |
| 0.06% | TSHA | TAYSHA GENE THERAPIES INC | -- | $49,683.80 | 11,972 | BNC1BX1 |
| 0.06% | WVE | WAVE LIFE SCIENCES LTD | -- | $49,656.24 | 6,984 | BYZG9R0 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $49,502.42 | 638 | BNSP8K3 |
| 0.06% | RLAY | RELAY THERAPEUTICS INC | -- | $49,261.17 | 7,567 | BN2R582 |
| 0.06% | PCRX | PACIRA BIOSCIENCES INC | -- | $48,121.47 | 1,973 | B3X26D8 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $48,015.54 | 13,119 | BL53SR3 |
| 0.06% | URGN | UROGEN PHARMA LTD | -- | $47,877.15 | 2,033 | BZ7PJQ1 |
| 0.06% | NVAX | NOVAVAX INC | -- | $46,830.96 | 7,128 | BJDQXG4 |
| 0.06% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $46,650.00 | 3,110 | BJLKVS6 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $46,053.00 | 5,355 | B8K7T65 |
| 0.06% | ANAB | ANAPTYSBIO INC | -- | $45,559.31 | 1,231 | BDRW1L7 |
| 0.05% | ORKA | ORUKA THERAPEUTICS INC | -- | $45,018.00 | 1,640 | BKVF0J2 |
| 0.05% | ZLAB | ZAI LAB LTD-ADR | -- | $43,048.96 | 2,102 | BD9GVY0 |
| 0.05% | CSTL | CASTLE BIOSCIENCES INC | -- | $42,608.50 | 1,270 | BKLCWZ3 |
| 0.05% | NRIX | NURIX THERAPEUTICS INC | -- | $42,579.44 | 3,358 | BMVLGP2 |
| 0.05% | EYPT | EYEPOINT PHARMACEUTICALS INC | -- | $42,242.96 | 3,026 | BMGS7L1 |
| 0.05% | KURA | KURA ONCOLOGY INC | -- | $42,214.80 | 3,810 | BYZD465 |
| 0.05% | ARVN | ARVINAS INC | -- | $41,866.77 | 3,223 | BDZ30Q0 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $40,862.90 | 2,210 | BMNDK09 |
| 0.05% | FTRE | FORTREA HOLDINGS INC | -- | $40,626.60 | 3,983 | BRXYZ57 |
| 0.05% | RAPP | RAPPORT THERAPEUTICS INC | -- | $40,587.96 | 1,603 | BR3T9B6 |
| 0.05% | SANA | SANA BIOTECHNOLOGY INC | -- | $40,090.21 | 11,357 | BMFJJ97 |
| 0.05% | NTLA | INTELLIA THERAPEUTICS INC | -- | $39,893.70 | 4,710 | BYZM6C2 |
| 0.05% | TNGX | TANGO THERAPEUTICS INC | -- | $39,096.00 | 4,887 | BP2P6L0 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $38,764.28 | 15,887 | BF0DMK7 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $38,738.34 | 893 | BL95N25 |
| 0.05% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $38,513.58 | 4,494 | BLB0YH0 |
| 0.05% | MNMD | MIND MEDICINE MINDMED INC | -- | $38,155.04 | 3,344 | BPQYY97 |
| 0.05% | TYRA | TYRA BIOSCIENCES INC | -- | $37,581.72 | 2,343 | BMVNDH9 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $37,455.65 | 8,417 | BZ0QMB7 |
| 0.05% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $37,357.58 | 2,711 | BP7KZP7 |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $36,467.58 | 789 | BQD3J33 |
| 0.04% | AVBP | ARRIVENT BIOPHARMA INC | -- | $35,953.59 | 1,779 | BMGTLY5 |
| 0.04% | ERAS | ERASCA INC | -- | $35,618.44 | 12,454 | BNLYBF3 |
| 0.04% | LENZ | LENZ THERAPEUTICS INC | -- | $34,064.73 | 1,251 | BQV0J03 |
| 0.04% | VIR | VIR BIOTECHNOLOGY INC | -- | $33,533.50 | 6,097 | BK4PZ38 |
| 0.04% | CRMD | CORMEDIX INC | -- | $33,035.93 | 3,279 | BJ0LT31 |
| 0.04% | SVRA | SAVARA INC | -- | $31,654.47 | 7,591 | BYXGN81 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $31,522.43 | 2,209 | BD06CS0 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $31,364.37 | 5,307 | BYVQJ96 |
| 0.04% | KROS | KEROS THERAPEUTICS INC | -- | $31,239.00 | 1,780 | BM7V485 |
| 0.04% | GERN | GERON CORP | -- | $31,087.77 | 28,007 | 2370381 |
| 0.04% | ATXS | ASTRIA THERAPEUTICS INC | -- | $30,962.71 | 2,479 | BMYRFN8 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $30,822.30 | 2,070 | BQS7491 |
| 0.04% | SPRY | ARS PHARMACEUTICALS INC | -- | $30,727.65 | 4,337 | BMCR7V2 |
| 0.04% | REPL | REPLIMUNE GROUP INC | -- | $29,969.46 | 3,429 | BDDVW37 |
| 0.04% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $29,760.66 | 3,274 | BYP80F1 |
| 0.04% | PSNL | PERSONALIS INC | -- | $29,657.04 | 3,892 | BJQ0608 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $27,357.50 | 3,530 | BFYQFJ2 |
| 0.03% | ALMS | ALUMIS INC | -- | $27,261.73 | 4,253 | BPLQG36 |
| 0.03% | PRME | PRIME MEDICINE INC | -- | $27,256.90 | 7,678 | BPBJFM7 |
| 0.03% | OMER | OMEROS CORP | -- | $25,406.50 | 2,989 | B4NB858 |
| 0.03% | ESPR | ESPERION THERAPEUTICS INC | -- | $25,053.99 | 8,853 | BBNBTD2 |
| 0.03% | RGNX | REGENXBIO INC | -- | $24,918.75 | 2,215 | BZ0G875 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $24,459.96 | 2,361 | B91XRN2 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $23,929.90 | 2,467 | BLFBZ32 |
| 0.03% | LXRX | LEXICON PHARMACEUTICALS INC | -- | $23,455.32 | 15,956 | BWFZX59 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $23,001.48 | 6,354 | BMCWKZ2 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $22,168.08 | 7,128 | B3MZ6K5 |
| 0.03% | CGEM | CULLINAN THERAPEUTICS INC | -- | $22,118.60 | 2,590 | BM90J52 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $21,758.55 | 13,187 | B4N8MH9 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $21,738.24 | 2,368 | BQ6C357 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $21,705.53 | 4,027 | BMC3HS7 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $20,684.50 | 2,050 | BKLXFX5 |
| 0.02% | HCM | HUTCHMED CHINA-ADR | -- | $20,010.90 | 1,365 | BYXV9H7 |
| 0.02% | EOLS | EVOLUS INC | -- | $19,979.26 | 2,842 | BDRJH21 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $19,225.44 | 632 | B292NQ7 |
| 0.02% | DSGN | DESIGN THERAPEUTICS INC | -- | $18,967.41 | 2,499 | BMFK3H6 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $18,909.94 | 7,109 | BN4JN37 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $18,769.68 | 3,144 | 2107437 |
| 0.02% | ABSI | ABSCI CORP | -- | $18,650.28 | 6,567 | BN94K69 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $18,023.40 | 3,876 | BFY7DC4 |
| 0.02% | ANNX | ANNEXON INC | -- | $15,440.00 | 4,825 | BMVV9R5 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $15,291.87 | 3,421 | BQHN6C7 |
| 0.02% | LYEL | LYELL IMMUNOPHARMA INC | -- | $15,186.71 | 847 | BTNMG41 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $14,989.60 | 820 | BPBPCG8 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $14,869.17 | 1,899 | BSMLR16 |
| 0.02% | AMRN | AMARIN CORP PLC -ADR | -- | $14,771.64 | 884 | BN72KB0 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $14,747.04 | 1,672 | BP81RK8 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $14,742.25 | 2,725 | BP81R42 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $13,935.60 | 4,740 | BDFKQ07 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $13,911.75 | 2,061 | BL5B6Z1 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $13,861.85 | 2,591 | B12W3P6 |
| 0.02% | NGNE | NEUROGENE INC | -- | $13,456.80 | 630 | BS2F741 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $13,441.35 | 4,407 | BZC0D70 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $13,184.50 | 3,767 | BYTYP72 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $13,147.04 | 2,032 | BKDQKM6 |
| 0.02% | PYXS | PYXIS ONCOLOGY INC | -- | $12,843.12 | 2,721 | BLBR8D5 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $12,760.71 | 9,741 | BFZNYB7 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $12,729.45 | 3,755 | BMXNGZ6 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $12,464.66 | 2,483 | BMF7DT9 |
| 0.01% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $11,618.40 | 940 | B9L5200 |
| 0.01% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $11,357.16 | 8,804 | BFMLGR4 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $10,635.35 | 3,487 | BLN9Z50 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $10,413.24 | 2,433 | BY7RB53 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $10,359.09 | 2,349 | BP7L561 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $10,346.38 | 3,949 | BZ8FPH3 |
| 0.01% | RNAC | CARTESIAN THERAPEUTICS INC | -- | $8,724.90 | 1,145 | BQB9HM8 |
| 0.01% | OABI | OMNIAB INC | -- | $8,666.63 | 5,383 | BN13S71 |
| 0.01% | HUMA | HUMACYTE INC | -- | $8,344.80 | 6,954 | BMYTJP4 |
| 0.01% | PEPG | PEPGEN INC | -- | $8,282.82 | 1,443 | BMTX3D7 |
| 0.01% | MXCT | MAXCYTE INC | -- | $8,004.51 | 4,681 | BKMQF66 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $7,877.80 | 1,190 | BKC9SX3 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $7,754.96 | 3,127 | BKX9NQ0 |
| 0.01% | CDXS | CODEXIS INC | -- | $6,497.68 | 3,962 | B5LL2C2 |
| 0.01% | MRSN | MERSANA THERAPEUTICS INC | -- | $6,031.26 | 219 | BVPKH99 |
| 0.01% | CLYM | CLIMB BIO INC | -- | $5,687.98 | 2,978 | BMW5LX6 |
| 0.01% | NKTX | NKARTA INC | -- | $5,650.82 | 3,122 | BK80YJ8 |
| 0.01% | ALEC | ALECTOR INC | -- | $5,646.42 | 4,446 | BJ4LDC4 |
| 0.01% | FATE | FATE THERAPEUTICS INC | -- | $5,163.24 | 5,062 | BCZS820 |
| 0.01% | MGNX | MACROGENICS INC | -- | $4,275.04 | 2,776 | BFDV8K0 |
| 0.01% | PLRX | PLIANT THERAPEUTICS INC | -- | $4,234.29 | 2,697 | BMDWW66 |
| 0.01% | ARTV | ARTIVA BIOTHERAPEUTICS INC | -- | $4,181.75 | 1,075 | BMF1LJ7 |
| -- | TVGN | TEVOGEN BIO HOLDINGS INC | -- | $3,533.40 | 8,637 | BPG5P75 |
| -- | ACRV | ACRIVON THERAPEUTICS INC | -- | $3,358.26 | 1,382 | BP2TPK4 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $3,313.47 | 3,723 | BF12XC2 |
| -- | BMEA | BIOMEA FUSION INC | -- | $3,085.70 | 2,615 | BNKF6N0 |
| -- | TCRX | TSCAN THERAPEUTICS INC | -- | $2,277.23 | 2,300 | BNLYBJ7 |
| -- | APLT | APPLIED THERAPEUTICS INC | -- | $1,881.11 | 6,304 | BJL38Z1 |
| -- | OKUR | ONKURE THERAPEUTICS INC-A | -- | $1,658.38 | 566 | BT7KGT6 |
| -- | QTTB | Q32 BIO INC | -- | $1,215.24 | 533 | BS2FKQ4 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 39.17% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 32,308,220 | -- | 5,759 | -- |
| 34.66% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 28,588,764 | -- | 5,096 | -- |
| 20.92% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 17,250,873 | -- | 3,075 | -- |
| 16.90% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 13,935,339 | -- | 2,484 | -- |
| 15.64% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 12,897,482 | -- | 2,299 | -- |
| 7.86% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 6,479,596 | -- | 1,155 | -- |
| -- | -- | TREASURY BILL | -- | $4,999,470.85 | 5,000,000 | BMGHP58 |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $23,696,331.37 | 23,696,331 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
Read More