BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 12/31/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 2/03/2026- NAV $84.87
- NAV Change $-0.12
- Market Price $84.81
- Market Price Change $-0.16
- Trading Volume (M) 7,525
- 30-Day Median Bid Ask Spread 0.28%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 2/03/2026- NAV $84.87
- NAV Change $-0.12
- Market Price $84.81
- Market Price Change $-0.16
- Trading Volume (M) 7,525
- 30-Day Median Bid Ask Spread 0.28%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 12/31/2025
Holdings
as of 2/03/2026
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 6.51% | GILD | GILEAD SCIENCES INC | -- | $5,797,538.64 | 40,463 | 2369174 |
| 6.14% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,467,658.23 | 11,743 | 2931034 |
| 5.60% | AMGN | AMGEN INC | -- | $4,990,478.01 | 14,739 | 2023607 |
| 4.12% | REGN | REGENERON PHARMACEUTICALS | -- | $3,671,394.48 | 4,836 | 2730190 |
| 2.44% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,176,234.80 | 6,186 | B00FWN1 |
| 1.76% | INSM | INSMED INC | -- | $1,569,399.76 | 9,986 | 2614487 |
| 1.36% | BIIB | BIOGEN INC | -- | $1,214,164.44 | 6,869 | 2455965 |
| 1.30% | ARGX | ARGENX SE - ADR | -- | $1,160,894.36 | 1,363 | BDVLM39 |
| 1.09% | ILMN | ILLUMINA INC | -- | $968,866.22 | 7,154 | 2613990 |
| 1.08% | UTHR | UNITED THERAPEUTICS CORP | -- | $964,192.32 | 2,016 | 2430412 |
| 1.04% | INCY | INCYTE CORP | -- | $927,656.64 | 9,192 | 2471950 |
| 0.97% | RVMD | REVOLUTION MEDICINES INC | -- | $868,720.44 | 9,052 | BL71K91 |
| 0.96% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $859,614.85 | 20,005 | BMVP7Y0 |
| 0.87% | MRNA | MODERNA INC | -- | $771,922.40 | 18,292 | BGSXTS3 |
| 0.84% | MEDP | MEDPACE HOLDINGS INC | -- | $749,891.07 | 1,319 | BDCBC61 |
| 0.83% | VTRS | VIATRIS INC | -- | $737,735.04 | 53,928 | BMWS3X9 |
| 0.80% | ROIV | ROIVANT SCIENCES LTD | -- | $715,431.08 | 32,564 | BMW4NZ9 |
| 0.79% | BBIO | BRIDGEBIO PHARMA INC | -- | $705,339.96 | 9,022 | BK1KWG8 |
| 0.77% | GH | GUARDANT HEALTH INC | -- | $684,856.90 | 6,058 | BFXC911 |
| 0.73% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $648,758.64 | 4,668 | 2623911 |
| 0.72% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $645,926.25 | 2,875 | BV9G6B8 |
| 0.72% | IONS | IONIS PHARMACEUTICALS INC | -- | $641,530.56 | 7,584 | BDJ0LS6 |
| 0.66% | SNY | SANOFI-ADR | -- | $588,401.10 | 12,390 | 2964557 |
| 0.60% | EXEL | EXELIXIS INC | -- | $534,674.86 | 12,554 | 2576941 |
| 0.58% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $518,201.95 | 8,995 | 2437071 |
| 0.58% | RNA | AVIDITY BIOSCIENCES INC | -- | $514,521.15 | 7,055 | BMWHPY1 |
| 0.58% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $512,844.35 | 1,063 | BD59BS7 |
| 0.58% | BNTX | BIONTECH SE-ADR | -- | $512,455.50 | 4,734 | BK6H543 |
| 0.57% | ONC | BEONE MEDICINES LTD-ADR | -- | $510,564.12 | 1,474 | BYYWPW6 |
| 0.57% | SMMT | SUMMIT THERAPEUTICS INC | -- | $508,549.04 | 34,856 | BMTVQS7 |
| 0.53% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $474,659.80 | 2,845 | B4Q5ZN4 |
| 0.51% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $458,738.26 | 6,359 | BYQBFJ8 |
| 0.51% | TEM | TEMPUS AI INC | -- | $453,021.18 | 8,094 | BSLSJJ0 |
| 0.50% | AXSM | AXSOME THERAPEUTICS INC | -- | $442,146.00 | 2,360 | BYZR4X4 |
| 0.47% | HALO | HALOZYME THERAPEUTICS INC | -- | $421,098.88 | 5,506 | 2975098 |
| 0.43% | KRYS | KRYSTAL BIOTECH INC | -- | $379,656.06 | 1,358 | BD6JX35 |
| 0.42% | CYTK | CYTOKINETICS INC | -- | $370,579.25 | 5,725 | BBBSBJ5 |
| 0.41% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $363,618.92 | 1,171 | BQ721R4 |
| 0.41% | NUVL | NUVALENT INC-A | -- | $362,448.94 | 3,382 | BMVBZD3 |
| 0.38% | PCVX | VAXCYTE INC | -- | $341,569.17 | 6,129 | BKPVGH6 |
| 0.38% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $338,406.25 | 3,125 | BF2YWG4 |
| 0.35% | ABVX | ABIVAX SA-ADR | -- | $313,216.48 | 2,764 | BLC89B2 |
| 0.34% | CAI | CARIS LIFE SCIENCES INC | -- | $306,495.20 | 13,211 | BT18HP9 |
| 0.33% | IBRX | IMMUNITYBIO INC | -- | $291,926.94 | 46,118 | BNSP0B8 |
| 0.32% | PTCT | PTC THERAPEUTICS INC | -- | $281,285.97 | 3,759 | B17VCN9 |
| 0.30% | COGT | COGENT BIOSCIENCES INC | -- | $267,931.36 | 7,187 | BLR6XK8 |
| 0.30% | ALKS | ALKERMES PLC | -- | $266,487.57 | 7,731 | B3P6D26 |
| 0.29% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $262,147.62 | 3,129 | BQS9486 |
| 0.29% | KYMR | KYMERA THERAPEUTICS INC | -- | $260,154.18 | 3,369 | BMPRZV5 |
| 0.28% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $253,712.70 | 2,406 | BJDX8Y8 |
| 0.28% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $250,521.93 | 2,927 | BDCBCD8 |
| 0.26% | CRSP | CRISPR THERAPEUTICS AG | -- | $232,024.00 | 4,462 | BDHF4K6 |
| 0.26% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $229,009.20 | 4,776 | BFZQ0L8 |
| 0.25% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $221,972.28 | 4,443 | BDD19F8 |
| 0.24% | IMVT | IMMUNOVANT INC | -- | $211,740.60 | 8,207 | BJRFSB7 |
| 0.24% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $209,745.75 | 14,719 | BFNF1D6 |
| 0.23% | INDV | INDIVIOR PHARMACEUTICALS INC | -- | $207,169.80 | 5,844 | BTZRLN8 |
| 0.23% | FOLD | AMICUS THERAPEUTICS INC | -- | $206,288.88 | 14,446 | B19FQ48 |
| 0.22% | CGON | CG ONCOLOGY INC | -- | $198,519.12 | 3,777 | BRBCSP4 |
| 0.22% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $196,123.96 | 7,921 | 2713317 |
| 0.22% | ADMA | ADMA BIOLOGICS INC | -- | $195,242.88 | 11,144 | B9NSBM2 |
| 0.22% | GRAL | GRAIL INC | -- | $192,391.50 | 1,825 | BSLSSX7 |
| 0.21% | ACLX | ARCELLX INC | -- | $188,028.22 | 2,707 | BPCJ1Q2 |
| 0.21% | LGND | LIGAND PHARMACEUTICALS | -- | $183,330.48 | 922 | 2501578 |
| 0.20% | APGE | APOGEE THERAPEUTICS INC | -- | $176,840.63 | 2,567 | BM9HHL5 |
| 0.20% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $175,143.91 | 5,309 | BP8JSP4 |
| 0.18% | TERN | TERNS PHARMACEUTICALS INC | -- | $162,477.36 | 4,218 | BMDJ0C9 |
| 0.17% | XENE | XENON PHARMACEUTICALS INC | -- | $152,390.16 | 3,618 | BRJ3GY4 |
| 0.17% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $150,199.65 | 5,735 | BKX9VD3 |
| 0.17% | DNLI | DENALI THERAPEUTICS INC | -- | $149,563.26 | 6,867 | BD2B4V0 |
| 0.16% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $146,975.05 | 4,957 | BKY5JZ8 |
| 0.16% | IRON | DISC MEDICINE INC | -- | $140,927.28 | 1,768 | BMGJZJ8 |
| 0.16% | ERAS | ERASCA INC | -- | $140,611.14 | 13,284 | BNLYBF3 |
| 0.16% | IDYA | IDEAYA BIOSCIENCES INC | -- | $140,514.15 | 4,105 | BK0VHF6 |
| 0.16% | VCYT | VERACYTE INC | -- | $139,675.74 | 3,701 | BFTWZY0 |
| 0.15% | APLS | APELLIS PHARMACEUTICALS INC | -- | $138,077.72 | 5,921 | BYTQ6X1 |
| 0.15% | TVTX | TRAVERE THERAPEUTICS INC | -- | $137,566.76 | 4,189 | BLFGJD5 |
| 0.15% | VERA | VERA THERAPEUTICS INC | -- | $133,607.97 | 2,991 | BL55460 |
| 0.15% | TARS | TARSUS PHARMACEUTICALS INC | -- | $132,917.68 | 1,988 | BMH5RL1 |
| 0.15% | TWST | TWIST BIOSCIENCE CORP | -- | $132,614.16 | 2,863 | BGKG6G7 |
| 0.15% | BEAM | BEAM THERAPEUTICS INC | -- | $132,505.39 | 4,751 | BK6L288 |
| 0.15% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $132,238.00 | 7,148 | BJ5FZ74 |
| 0.15% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $129,954.00 | 2,685 | B72ZBG4 |
| 0.14% | DYN | DYNE THERAPEUTICS INC | -- | $126,785.52 | 6,687 | BN15WD1 |
| 0.14% | ALMS | ALUMIS INC | -- | $123,086.08 | 4,552 | BPLQG36 |
| 0.14% | SYRE | SPYRE THERAPEUTICS INC | -- | $120,942.57 | 3,633 | BQBBDY8 |
| 0.13% | MLYS | MINERALYS THERAPEUTICS INC | -- | $116,929.80 | 3,705 | BP9N0G0 |
| 0.13% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $115,093.16 | 4,517 | BLB0YQ9 |
| 0.13% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $112,021.60 | 4,517 | BJ62Z18 |
| 0.12% | MAZE | MAZE THERAPEUTICS INC | -- | $108,076.41 | 2,253 | BSRK699 |
| 0.12% | WVE | WAVE LIFE SCIENCES LTD | -- | $107,284.70 | 7,831 | BYZG9R0 |
| 0.12% | TXG | 10X GENOMICS INC-CLASS A | -- | $105,153.12 | 5,454 | BKS3RS7 |
| 0.11% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $101,083.56 | 2,697 | BKSGZN7 |
| 0.11% | SRPT | SAREPTA THERAPEUTICS INC | -- | $99,493.68 | 4,906 | B8DPDT7 |
| 0.11% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $98,707.50 | 24,075 | BM9FJ13 |
| 0.11% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $96,273.62 | 3,683 | BMZ4LN0 |
| 0.11% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $95,090.40 | 2,115 | BRXB0C0 |
| 0.11% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $93,891.33 | 6,173 | BFWLC09 |
| 0.10% | SION | SIONNA THERAPEUTICS INC | -- | $92,963.20 | 2,090 | BQKXDX4 |
| 0.10% | GMAB | GENMAB A/S -SP ADR | -- | $90,403.11 | 2,737 | BBC9WC7 |
| 0.10% | STOK | STOKE THERAPEUTICS INC | -- | $90,388.25 | 2,675 | BJQ05Z6 |
| 0.10% | MNKD | MANNKIND CORP | -- | $89,287.38 | 14,378 | BF081J4 |
| 0.10% | ARDX | ARDELYX INC | -- | $88,057.98 | 11,377 | BN89V40 |
| 0.10% | VCEL | VERICEL CORP | -- | $87,852.80 | 2,368 | BSBMN89 |
| 0.10% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $86,487.50 | 4,070 | BN7Q7R7 |
| 0.10% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $85,109.04 | 5,498 | BRJZSK0 |
| 0.10% | OCUL | OCULAR THERAPEUTIX INC | -- | $84,887.25 | 9,975 | BNZB1X8 |
| 0.09% | ANIP | ANI PHARMACEUTICALS INC | -- | $84,033.76 | 1,052 | BCDWBX6 |
| 0.09% | PHVS | PHARVARIS NV | -- | $83,402.19 | 2,999 | BMZ2X38 |
| 0.09% | DFTX | DEFINIUM THERAPEUTICS INC | -- | $82,554.80 | 4,612 | BV2DHY6 |
| 0.09% | MBX | MBX BIOSCIENCES INC | -- | $82,440.44 | 2,102 | BQXJKH2 |
| 0.09% | ZYME | ZYMEWORKS INC | -- | $82,133.76 | 3,504 | BPCQZY9 |
| 0.09% | HROW | HARROW INC | -- | $81,827.46 | 1,734 | BHNDW86 |
| 0.09% | QURE | UNIQURE NV | -- | $81,092.60 | 2,917 | BJFSR88 |
| 0.09% | NRIX | NURIX THERAPEUTICS INC | -- | $79,685.34 | 4,746 | BMVLGP2 |
| 0.09% | PGEN | PRECIGEN INC | -- | $79,521.60 | 16,567 | BKM5C84 |
| 0.09% | TNGX | TANGO THERAPEUTICS INC | -- | $79,140.30 | 6,306 | BP2P6L0 |
| 0.09% | ORKA | ORUKA THERAPEUTICS INC | -- | $78,324.85 | 2,267 | BKVF0J2 |
| 0.09% | TYRA | TYRA BIOSCIENCES INC | -- | $78,068.76 | 2,499 | BMVNDH9 |
| 0.09% | UPB | UPSTREAM BIO INC | -- | $77,898.70 | 2,530 | BRCFFK6 |
| 0.09% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $76,700.40 | 2,779 | BMFD115 |
| 0.09% | ALVO | ALVOTECH SA | -- | $76,357.76 | 14,656 | BPNTJ34 |
| 0.09% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $76,248.90 | 2,730 | BCBVTX1 |
| 0.08% | RAPT | RAPT THERAPEUTICS INC | -- | $74,901.75 | 1,297 | BTJZB49 |
| 0.08% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $74,625.98 | 3,497 | BYP80F1 |
| 0.08% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $74,507.58 | 5,142 | BPCK358 |
| 0.08% | INVA | INNOVIVA INC | -- | $73,521.00 | 3,501 | BDDXF67 |
| 0.08% | NTLA | INTELLIA THERAPEUTICS INC | -- | $70,770.15 | 5,423 | BYZM6C2 |
| 0.08% | RLAY | RELAY THERAPEUTICS INC | -- | $70,357.05 | 8,115 | BN2R582 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $70,314.80 | 1,480 | BX7RSN3 |
| 0.08% | FTRE | FORTREA HOLDINGS INC | -- | $70,297.50 | 4,326 | BRXYZ57 |
| 0.08% | TRVI | TREVI THERAPEUTICS INC | -- | $68,925.92 | 6,004 | BJH9ZN0 |
| 0.07% | ANAB | ANAPTYSBIO INC | -- | $66,368.16 | 1,296 | BDRW1L7 |
| 0.07% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $66,048.60 | 9,858 | 2100362 |
| 0.07% | ATAI | ATAIBECKLEY INC | -- | $65,809.35 | 17,005 | BWJDYK1 |
| 0.07% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $65,673.72 | 3,942 | BMX9K07 |
| 0.07% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $65,519.01 | 2,043 | BLCD809 |
| 0.07% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $63,815.57 | 3,049 | BP7KZP7 |
| 0.07% | NVAX | NOVAVAX INC | -- | $63,687.33 | 7,609 | BJDQXG4 |
| 0.07% | NVCR | NOVOCURE LTD | -- | $62,077.12 | 5,243 | BYSS4X4 |
| 0.07% | RAPP | RAPPORT THERAPEUTICS INC | -- | $61,246.08 | 2,232 | BR3T9B6 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $60,772.48 | 2,152 | BNFWZS4 |
| 0.07% | TSHA | TAYSHA GENE THERAPIES INC | -- | $60,534.00 | 12,825 | BNC1BX1 |
| 0.07% | KOD | KODIAK SCIENCES INC | -- | $59,690.52 | 2,484 | BFXC933 |
| 0.07% | INBX | INHIBRX BIOSCIENCES INC | -- | $57,939.48 | 681 | BNSP8K3 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $57,024.46 | 7,769 | BLR7H87 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $55,001.52 | 12,472 | BMFJJ97 |
| 0.06% | SVRA | SAVARA INC | -- | $53,922.82 | 9,527 | BYXGN81 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $53,807.04 | 5,712 | B8K7T65 |
| 0.06% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $53,646.12 | 4,807 | BLB0YH0 |
| 0.06% | SEPN | SEPTERNA INC | -- | $53,531.84 | 2,096 | BQNKXX2 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $53,230.98 | 1,367 | BKLCWZ3 |
| 0.06% | ORIC | ORIC PHARMACEUTICALS INC | -- | $50,160.00 | 4,560 | BKVDFF7 |
| 0.06% | VIR | VIR BIOTECHNOLOGY INC | -- | $50,027.52 | 6,514 | BK4PZ38 |
| 0.06% | EYPT | EYEPOINT INC | -- | $49,612.80 | 3,876 | BMGS7L1 |
| 0.06% | ZBIO | ZENAS BIOPHARMA INC | -- | $49,556.36 | 2,513 | BQB42H3 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $49,332.80 | 14,015 | BL53SR3 |
| 0.06% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $49,069.68 | 18,587 | BF0DMK7 |
| 0.05% | CTMX | CYTOMX THERAPEUTICS INC | -- | $48,153.31 | 7,933 | BYWVTY5 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $47,436.27 | 2,373 | BMNDK09 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $46,974.20 | 4,628 | BMCR7V2 |
| 0.05% | VTYX | VENTYX BIOSCIENCES INC | -- | $46,606.95 | 3,341 | BMG99Y1 |
| 0.05% | GHRS | GH RESEARCH PLC | -- | $46,231.68 | 2,904 | BP6C0S2 |
| 0.05% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $46,001.11 | 3,331 | BJLKVS6 |
| 0.05% | GERN | GERON CORP | -- | $45,132.39 | 29,889 | 2370381 |
| 0.05% | ANNX | ANNEXON INC | -- | $43,914.96 | 6,777 | BMVV9R5 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $43,840.00 | 2,192 | BZ7PJQ1 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $43,753.46 | 1,933 | BMGTLY5 |
| 0.05% | BCAX | BICARA THERAPEUTICS INC | -- | $43,630.65 | 2,565 | BQB42F1 |
| 0.05% | PCRX | PACIRA BIOSCIENCES INC | -- | $42,334.28 | 2,014 | B3X26D8 |
| 0.05% | ARVN | ARVINAS INC | -- | $41,045.55 | 3,007 | BDZ30Q0 |
| 0.04% | XNCR | XENCOR INC | -- | $40,094.56 | 3,344 | BGCYWN8 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $39,812.64 | 2,296 | BQS7491 |
| 0.04% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $39,616.29 | 959 | BL95N25 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $39,287.43 | 11,193 | BBNBTD2 |
| 0.04% | OMER | OMEROS CORP | -- | $39,242.40 | 3,320 | B4NB858 |
| 0.04% | JANX | JANUX THERAPEUTICS INC | -- | $38,860.80 | 2,816 | BMFX8Y7 |
| 0.04% | PSNL | PERSONALIS INC | -- | $38,253.60 | 4,158 | BJQ0608 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $38,179.71 | 2,367 | BD06CS0 |
| 0.04% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $37,010.55 | 9,005 | BZ0QMB7 |
| 0.04% | CGEM | CULLINAN THERAPEUTICS INC | -- | $36,538.86 | 2,766 | BM90J52 |
| 0.04% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $36,485.43 | 7,617 | B3MZ6K5 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $33,529.02 | 4,074 | BYZD465 |
| 0.04% | BIOA | BIOAGE LABS INC | -- | $33,428.89 | 1,679 | BT9K6D8 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $32,202.12 | 8,452 | BPBJFM7 |
| 0.03% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $30,770.00 | 850 | BQD3J33 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $30,302.76 | 3,769 | BFYQFJ2 |
| 0.03% | ZLAB | ZAI LAB LTD-ADR | -- | $30,116.19 | 1,833 | BD9GVY0 |
| 0.03% | CRMD | CORMEDIX INC | -- | $29,954.68 | 3,689 | BJ0LT31 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $29,075.08 | 4,412 | BMC3HS7 |
| 0.03% | GOSS | GOSSAMER BIO INC | -- | $28,934.79 | 10,837 | BJ0CK86 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $28,837.44 | 14,136 | B4N8MH9 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $27,656.79 | 2,667 | BMFK3H6 |
| 0.03% | REPL | REPLIMUNE GROUP INC | -- | $27,106.74 | 3,673 | BDDVW37 |
| 0.03% | ALT | ALTIMMUNE INC | -- | $26,726.42 | 4,886 | BFY7DC4 |
| 0.03% | FULC | FULCRUM THERAPEUTICS INC | -- | $26,581.66 | 2,534 | BJDX8Z9 |
| 0.03% | KROS | KEROS THERAPEUTICS INC | -- | $26,338.22 | 1,426 | BM7V485 |
| 0.03% | RGNX | REGENXBIO INC | -- | $25,738.20 | 2,370 | BZ0G875 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $25,695.84 | 3,417 | BQ6C357 |
| 0.03% | LYEL | LYELL IMMUNOPHARMA INC | -- | $25,589.61 | 993 | BTNMG41 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $25,385.75 | 2,675 | BKLXFX5 |
| 0.03% | IVVD | INVIVYD INC | -- | $24,393.00 | 12,975 | BM8NHS1 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $24,145.76 | 2,636 | BLFBZ32 |
| 0.03% | SLDB | SOLID BIOSCIENCES INC | -- | $23,857.92 | 3,648 | BQHN6C7 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $23,424.20 | 677 | B292NQ7 |
| 0.03% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $23,419.20 | 5,712 | BYVQJ96 |
| 0.03% | SIGA | SIGA TECHNOLOGIES INC | -- | $23,303.35 | 3,353 | 2107437 |
| 0.03% | LENZ | LENZ THERAPEUTICS INC | -- | $22,751.45 | 1,465 | BQV0J03 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $22,274.35 | 2,767 | B12W3P6 |
| 0.02% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $22,135.40 | 6,790 | BMCWKZ2 |
| 0.02% | PRTA | PROTHENA CORP PLC | -- | $22,125.60 | 2,520 | B91XRN2 |
| 0.02% | KMDA | KAMADA LTD | -- | $22,121.19 | 2,701 | B2Q9833 |
| 0.02% | ABSI | ABSCI CORP | -- | $21,756.69 | 7,041 | BN94K69 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $21,104.10 | 1,790 | BP81RK8 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $20,095.44 | 876 | BPBPCG8 |
| 0.02% | ETON | ETON PHARMACEUTICALS INC | -- | $19,329.84 | 1,256 | BGL0JK3 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $18,363.37 | 4,183 | BYTYP72 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $18,333.07 | 1,351 | B9L5200 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $18,308.28 | 10,522 | BFZNYB7 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $17,659.62 | 2,973 | BP81R42 |
| 0.02% | ACRS | ACLARIS THERAPEUTICS INC | -- | $17,603.31 | 5,073 | BYV2W40 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $17,507.60 | 5,060 | BDFKQ07 |
| 0.02% | PEPG | PEPGEN INC | -- | $17,253.84 | 3,219 | BMTX3D7 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $17,084.83 | 2,051 | BSMLR16 |
| 0.02% | NBP | NOVABRIDGE BIOSCIENCES | -- | $16,940.64 | 4,868 | BKRRKY7 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $16,748.90 | 2,359 | B7F2TY6 |
| 0.02% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $16,457.22 | 1,082 | BPRBTY7 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $15,958.92 | 7,823 | BN4JN37 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $15,701.34 | 4,701 | BZC0D70 |
| 0.02% | CADL | CANDEL THERAPEUTICS INC | -- | $15,214.40 | 2,570 | BP0TQC5 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $15,067.12 | 2,648 | BMF7DT9 |
| 0.02% | AVIR | ATEA PHARMACEUTICALS INC | -- | $14,924.64 | 3,658 | BLN9Z50 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $14,842.93 | 3,023 | BMVBZF5 |
| 0.02% | EOLS | EVOLUS INC | -- | $14,264.50 | 3,035 | BDRJH21 |
| 0.02% | LFCR | LIFECORE BIOMEDICAL INC | -- | $13,979.38 | 1,754 | 2517058 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $13,827.60 | 4,008 | BMXNGZ6 |
| 0.01% | AARD | AARDVARK THERAPEUTICS INC | -- | $13,155.29 | 1,019 | BTXQTX3 |
| 0.01% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $12,996.00 | 2,166 | BKDQKM6 |
| 0.01% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $12,960.96 | 9,392 | BFMLGR4 |
| 0.01% | NGNE | NEUROGENE INC | -- | $12,731.00 | 725 | BS2F741 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $12,562.98 | 5,659 | BRK0149 |
| 0.01% | OABI | OMNIAB INC | -- | $11,862.40 | 6,740 | BN13S71 |
| 0.01% | CABA | CABALETTA BIO INC | -- | $11,673.13 | 4,507 | BK5MWR1 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $10,787.69 | 2,759 | BY7RB53 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $10,787.52 | 2,644 | BPRB2N7 |
| 0.01% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $10,643.16 | 2,199 | BL5B6Z1 |
| 0.01% | VOR | VOR BIOPHARMA INC | -- | $10,114.98 | 789 | BRJJYT3 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $9,980.04 | 9,156 | BNR5QT9 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $9,735.60 | 1,330 | BKC9SX3 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $9,525.12 | 1,452 | BP2NYN2 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $9,416.26 | 4,571 | BZ8FPH3 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $9,121.38 | 4,538 | BKX9NQ0 |
| 0.01% | HUMA | HUMACYTE INC | -- | $8,759.23 | 8,768 | BMYTJP4 |
| 0.01% | MENS | JYONG BIOTECH LTD | -- | $7,796.40 | 3,560 | BPTK6Z2 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $7,129.44 | 7,796 | BNNXX52 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $6,826.56 | 4,376 | BNYJR68 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $6,723.36 | 2,668 | BKTV702 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $6,114.64 | 2,506 | BP7L561 |
| 0.01% | CDXS | CODEXIS INC | -- | $5,751.44 | 4,229 | B5LL2C2 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $5,617.41 | 4,567 | BNNXX18 |
| -- | PYXS | PYXIS ONCOLOGY INC | -- | $4,343.35 | 2,915 | BLBR8D5 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $14.83 | 01 | BTFHQP5 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 39.28% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 35,001,770 | -- | 5,919 | -- |
| 29.30% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 26,107,926 | -- | 4,415 | -- |
| 23.51% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 20,951,389 | -- | 3,543 | -- |
| 17.51% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 15,605,621 | -- | 2,639 | -- |
| 16.48% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,689,035 | -- | 2,484 | -- |
| 4.20% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,743,220 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $27,102,659.01 | 27,102,659 | -- |
Index
as of 12/31/2025
- Total Number of Companies262
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$7.32 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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