BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 12/31/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 1/08/2026- NAV $82.33
- NAV Change $-3.97
- Market Price $82.35
- Market Price Change $-3.91
- Trading Volume (M) 16,059
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 1/08/2026- NAV $82.33
- NAV Change $-3.97
- Market Price $82.35
- Market Price Change $-3.91
- Trading Volume (M) 16,059
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 1/08/2026
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 6.05% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,275,915.44 | 11,233 | 2931034 |
| 5.35% | GILD | GILEAD SCIENCES INC | -- | $4,668,963.64 | 38,692 | 2369174 |
| 5.33% | AMGN | AMGEN INC | -- | $4,653,230.56 | 14,096 | 2023607 |
| 4.24% | REGN | REGENERON PHARMACEUTICALS | -- | $3,703,870.24 | 4,624 | 2730190 |
| 2.82% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $2,457,515.41 | 26,141 | 2989044 |
| 2.71% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,362,451.00 | 5,915 | B00FWN1 |
| 1.86% | INSM | INSMED INC | -- | $1,625,908.23 | 9,549 | 2614487 |
| 1.40% | BIIB | BIOGEN INC | -- | $1,221,834.00 | 6,569 | 2455965 |
| 1.19% | ARGX | ARGENX SE - ADR | -- | $1,037,423.28 | 1,304 | BDVLM39 |
| 1.14% | ILMN | ILLUMINA INC | -- | $997,623.03 | 6,841 | 2613990 |
| 1.08% | UTHR | UNITED THERAPEUTICS CORP | -- | $946,320.24 | 1,928 | 2430412 |
| 1.07% | INCY | INCYTE CORP | -- | $931,036.80 | 8,790 | 2471950 |
| 1.07% | RVMD | REVOLUTION MEDICINES INC | -- | $929,567.84 | 8,656 | BL71K91 |
| 0.88% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $770,133.54 | 19,129 | BMVP7Y0 |
| 0.87% | MEDP | MEDPACE HOLDINGS INC | -- | $756,625.22 | 1,261 | BDCBC61 |
| 0.78% | ROIV | ROIVANT SCIENCES LTD | -- | $678,207.42 | 31,139 | BMW4NZ9 |
| 0.74% | VTRS | VIATRIS INC | -- | $649,504.80 | 51,548 | BMWS3X9 |
| 0.73% | BBIO | BRIDGEBIO PHARMA INC | -- | $636,918.96 | 8,628 | BK1KWG8 |
| 0.72% | GH | GUARDANT HEALTH INC | -- | $629,822.08 | 5,792 | BFXC911 |
| 0.72% | SMMT | SUMMIT THERAPEUTICS INC | -- | $627,622.73 | 33,331 | BMTVQS7 |
| 0.69% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $605,184.48 | 4,464 | 2623911 |
| 0.68% | MRNA | MODERNA INC | -- | $592,109.82 | 17,487 | BGSXTS3 |
| 0.68% | IONS | IONIS PHARMACEUTICALS INC | -- | $591,328.08 | 7,252 | BDJ0LS6 |
| 0.66% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $573,853.75 | 2,749 | BV9G6B8 |
| 0.65% | SNY | SANOFI-ADR | -- | $570,244.24 | 11,848 | 2964557 |
| 0.65% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $565,675.74 | 1,017 | BD59BS7 |
| 0.61% | EXEL | EXELIXIS INC | -- | $529,976.60 | 12,004 | 2576941 |
| 0.61% | TEM | TEMPUS AI INC | -- | $529,038.04 | 7,739 | BSLSJJ0 |
| 0.59% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $518,587.55 | 8,593 | 2437071 |
| 0.56% | RNA | AVIDITY BIOSCIENCES INC | -- | $488,208.02 | 6,746 | BMWHPY1 |
| 0.52% | ONC | BEONE MEDICINES LTD-ADR | -- | $451,401.33 | 1,409 | BYYWPW6 |
| 0.51% | BNTX | BIONTECH SE-ADR | -- | $447,296.25 | 4,525 | BK6H543 |
| 0.50% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $436,040.25 | 2,721 | B4Q5ZN4 |
| 0.45% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $395,265.00 | 6,081 | BYQBFJ8 |
| 0.44% | HALO | HALOZYME THERAPEUTICS INC | -- | $379,764.45 | 5,265 | 2975098 |
| 0.43% | AXSM | AXSOME THERAPEUTICS INC | -- | $378,160.35 | 2,257 | BYZR4X4 |
| 0.42% | CYTK | CYTOKINETICS INC | -- | $366,432.84 | 5,787 | BBBSBJ5 |
| 0.41% | CAI | CARIS LIFE SCIENCES INC | -- | $356,854.00 | 12,632 | BT18HP9 |
| 0.38% | NUVL | NUVALENT INC-A | -- | $332,034.78 | 3,234 | BMVBZD3 |
| 0.38% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $329,705.60 | 1,120 | BQ721R4 |
| 0.37% | KRYS | KRYSTAL BIOTECH INC | -- | $323,334.09 | 1,299 | BD6JX35 |
| 0.35% | ABVX | ABIVAX SA-ADR | -- | $305,240.07 | 2,643 | BLC89B2 |
| 0.33% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $291,210.48 | 2,988 | BF2YWG4 |
| 0.32% | PTCT | PTC THERAPEUTICS INC | -- | $276,198.90 | 3,594 | B17VCN9 |
| 0.30% | PCVX | VAXCYTE INC | -- | $265,801.80 | 5,865 | BKPVGH6 |
| 0.28% | COGT | COGENT BIOSCIENCES INC | -- | $244,365.90 | 6,870 | BLR6XK8 |
| 0.28% | KYMR | KYMERA THERAPEUTICS INC | -- | $241,510.58 | 3,221 | BMPRZV5 |
| 0.28% | CRSP | CRISPR THERAPEUTICS AG | -- | $240,207.60 | 4,259 | BDHF4K6 |
| 0.26% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $226,163.52 | 4,248 | BDD19F8 |
| 0.26% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $224,479.80 | 2,799 | BDCBCD8 |
| 0.25% | ALKS | ALKERMES PLC | -- | $218,921.60 | 7,396 | B3P6D26 |
| 0.24% | IMVT | IMMUNOVANT INC | -- | $206,428.26 | 7,846 | BJRFSB7 |
| 0.23% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $203,843.25 | 7,575 | 2713317 |
| 0.23% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $200,739.06 | 2,997 | BQS9486 |
| 0.23% | INDV | INDIVIOR PLC | -- | $198,500.90 | 5,590 | BP0BQQ5 |
| 0.23% | FOLD | AMICUS THERAPEUTICS INC | -- | $197,263.92 | 13,814 | B19FQ48 |
| 0.22% | ADMA | ADMA BIOLOGICS INC | -- | $192,553.92 | 10,656 | B9NSBM2 |
| 0.22% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $190,348.56 | 4,568 | BFZQ0L8 |
| 0.22% | APGE | APOGEE THERAPEUTICS INC | -- | $190,213.40 | 2,455 | BM9HHL5 |
| 0.22% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $187,761.60 | 2,301 | BJDX8Y8 |
| 0.21% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $185,724.00 | 14,070 | BFNF1D6 |
| 0.21% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $181,720.80 | 5,076 | BP8JSP4 |
| 0.20% | LGND | LIGAND PHARMACEUTICALS | -- | $176,257.27 | 881 | 2501578 |
| 0.20% | GRAL | GRAIL INC | -- | $171,177.84 | 1,746 | BSLSSX7 |
| 0.19% | ACLX | ARCELLX INC | -- | $166,498.59 | 2,589 | BPCJ1Q2 |
| 0.19% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $163,861.92 | 5,484 | BKX9VD3 |
| 0.18% | VCYT | VERACYTE INC | -- | $154,420.20 | 3,545 | BFTWZY0 |
| 0.17% | TERN | TERNS PHARMACEUTICALS INC | -- | $152,326.41 | 4,033 | BMDJ0C9 |
| 0.17% | CGON | CG ONCOLOGY INC | -- | $151,283.44 | 3,608 | BRBCSP4 |
| 0.17% | APLS | APELLIS PHARMACEUTICALS INC | -- | $148,736.64 | 5,664 | BYTQ6X1 |
| 0.17% | TARS | TARSUS PHARMACEUTICALS INC | -- | $148,677.21 | 1,901 | BMH5RL1 |
| 0.16% | IDYA | IDEAYA BIOSCIENCES INC | -- | $142,987.75 | 3,925 | BK0VHF6 |
| 0.16% | XENE | XENON PHARMACEUTICALS INC | -- | $142,621.20 | 3,460 | BRJ3GY4 |
| 0.16% | TVTX | TRAVERE THERAPEUTICS INC | -- | $142,613.60 | 4,006 | BLFGJD5 |
| 0.16% | VERA | VERA THERAPEUTICS INC | -- | $136,536.47 | 2,863 | BL55460 |
| 0.15% | IRON | DISC MEDICINE INC | -- | $134,000.10 | 1,690 | BMGJZJ8 |
| 0.15% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $131,404.56 | 2,568 | B72ZBG4 |
| 0.15% | BEAM | BEAM THERAPEUTICS INC | -- | $127,204.00 | 4,543 | BK6L288 |
| 0.14% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $118,357.80 | 4,740 | BKY5JZ8 |
| 0.13% | MLYS | MINERALYS THERAPEUTICS INC | -- | $117,412.72 | 3,544 | BP9N0G0 |
| 0.13% | DYN | DYNE THERAPEUTICS INC | -- | $116,754.44 | 6,394 | BN15WD1 |
| 0.13% | DNLI | DENALI THERAPEUTICS INC | -- | $112,098.69 | 6,567 | BD2B4V0 |
| 0.13% | WVE | WAVE LIFE SCIENCES LTD | -- | $111,002.55 | 7,485 | BYZG9R0 |
| 0.13% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $109,086.60 | 6,835 | BJ5FZ74 |
| 0.12% | OCUL | OCULAR THERAPEUTIX INC | -- | $108,508.30 | 9,535 | BNZB1X8 |
| 0.12% | SRPT | SAREPTA THERAPEUTICS INC | -- | $108,342.00 | 4,680 | B8DPDT7 |
| 0.12% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $108,203.40 | 23,022 | BM9FJ13 |
| 0.12% | SYRE | SPYRE THERAPEUTICS INC | -- | $104,706.36 | 3,474 | BQBBDY8 |
| 0.12% | TXG | 10X GENOMICS INC-CLASS A | -- | $100,616.64 | 5,216 | BKS3RS7 |
| 0.11% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $100,243.99 | 4,319 | BJ62Z18 |
| 0.11% | IBRX | IMMUNITYBIO INC | -- | $98,784.00 | 44,100 | BNSP0B8 |
| 0.11% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $97,666.73 | 2,579 | BKSGZN7 |
| 0.11% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $95,233.95 | 4,319 | BLB0YQ9 |
| 0.11% | TWST | TWIST BIOSCIENCE CORP | -- | $95,048.64 | 2,736 | BGKG6G7 |
| 0.11% | VCEL | VERICEL CORP | -- | $92,253.45 | 2,265 | BSBMN89 |
| 0.10% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $90,492.99 | 5,903 | BFWLC09 |
| 0.10% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $90,057.54 | 3,522 | BMZ4LN0 |
| 0.10% | GMAB | GENMAB A/S -SP ADR | -- | $88,009.71 | 2,617 | BBC9WC7 |
| 0.10% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $86,823.10 | 3,770 | BMX9K07 |
| 0.10% | STOK | STOKE THERAPEUTICS INC | -- | $86,119.76 | 2,557 | BJQ05Z6 |
| 0.10% | HROW | HARROW INC | -- | $84,624.32 | 1,658 | BHNDW86 |
| 0.10% | NRIX | NURIX THERAPEUTICS INC | -- | $84,542.94 | 4,538 | BMVLGP2 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $84,378.06 | 2,022 | BRXB0C0 |
| 0.10% | MAZE | MAZE THERAPEUTICS INC | -- | $83,898.30 | 2,154 | BSRK699 |
| 0.10% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $83,228.49 | 3,891 | BN7Q7R7 |
| 0.09% | MNKD | MANNKIND CORP | -- | $82,625.48 | 13,748 | BF081J4 |
| 0.09% | ANIP | ANI PHARMACEUTICALS INC | -- | $81,526.24 | 1,006 | BCDWBX6 |
| 0.09% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $81,025.78 | 5,258 | BRJZSK0 |
| 0.09% | ALMS | ALUMIS INC | -- | $79,137.54 | 4,353 | BPLQG36 |
| 0.09% | ZYME | ZYMEWORKS INC | -- | $77,385.00 | 3,350 | BPCQZY9 |
| 0.09% | ARDX | ARDELYX INC | -- | $76,153.00 | 10,879 | BN89V40 |
| 0.09% | NVCR | NOVOCURE LTD | -- | $74,558.18 | 5,014 | BYSS4X4 |
| 0.08% | ERAS | ERASCA INC | -- | $73,798.62 | 12,702 | BNLYBF3 |
| 0.08% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $73,778.65 | 2,915 | BP7KZP7 |
| 0.08% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $73,525.76 | 2,611 | BCBVTX1 |
| 0.08% | SION | SIONNA THERAPEUTICS INC | -- | $73,126.80 | 1,998 | BQKXDX4 |
| 0.08% | PGEN | PRECIGEN INC | -- | $72,870.27 | 15,807 | BKM5C84 |
| 0.08% | TYRA | TYRA BIOSCIENCES INC | -- | $72,506.15 | 2,389 | BMVNDH9 |
| 0.08% | FTRE | FORTREA HOLDINGS INC | -- | $72,149.28 | 4,137 | BRXYZ57 |
| 0.08% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $71,826.12 | 9,426 | 2100362 |
| 0.08% | PHVS | PHARVARIS NV | -- | $71,700.00 | 2,868 | BMZ2X38 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $69,023.70 | 1,415 | BX7RSN3 |
| 0.08% | TNGX | TANGO THERAPEUTICS INC | -- | $66,661.65 | 6,030 | BP2P6L0 |
| 0.08% | UPB | UPSTREAM BIO INC | -- | $66,646.80 | 2,420 | BRCFFK6 |
| 0.08% | ALVO | ALVOTECH SA | -- | $66,290.95 | 14,015 | BPNTJ34 |
| 0.08% | INVA | INNOVIVA INC | -- | $65,788.20 | 3,348 | BDDXF67 |
| 0.07% | MNMD | MIND MEDICINE MINDMED INC | -- | $64,827.00 | 4,410 | BPQYY97 |
| 0.07% | QURE | UNIQURE NV | -- | $64,565.35 | 2,789 | BJFSR88 |
| 0.07% | ATAI | ATAIBECKLEY INC | -- | $64,556.17 | 16,261 | BWJDYK1 |
| 0.07% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $64,546.65 | 1,953 | BLCD809 |
| 0.07% | TRVI | TREVI THERAPEUTICS INC | -- | $64,356.61 | 5,741 | BJH9ZN0 |
| 0.07% | EYPT | EYEPOINT INC | -- | $63,315.56 | 3,707 | BMGS7L1 |
| 0.07% | KOD | KODIAK SCIENCES INC | -- | $63,222.50 | 2,375 | BFXC933 |
| 0.07% | TSHA | TAYSHA GENE THERAPIES INC | -- | $63,036.96 | 12,264 | BNC1BX1 |
| 0.07% | RLAY | RELAY THERAPEUTICS INC | -- | $62,080.00 | 7,760 | BN2R582 |
| 0.07% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $61,775.25 | 2,657 | BMFD115 |
| 0.07% | MBX | MBX BIOSCIENCES INC | -- | $61,747.20 | 2,010 | BQXJKH2 |
| 0.07% | RAPP | RAPPORT THERAPEUTICS INC | -- | $60,470.16 | 2,136 | BR3T9B6 |
| 0.07% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $60,397.77 | 7,429 | BLR7H87 |
| 0.07% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $58,168.11 | 4,917 | BPCK358 |
| 0.07% | ORKA | ORUKA THERAPEUTICS INC | -- | $57,208.80 | 2,167 | BKVF0J2 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $57,088.92 | 2,058 | BNFWZS4 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $55,160.31 | 13,421 | BL53SR3 |
| 0.06% | NTLA | INTELLIA THERAPEUTICS INC | -- | $54,504.12 | 5,181 | BYZM6C2 |
| 0.06% | ANAB | ANAPTYSBIO INC | -- | $54,312.00 | 1,240 | BDRW1L7 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $53,905.52 | 11,926 | BMFJJ97 |
| 0.06% | NVAX | NOVAVAX INC | -- | $53,398.50 | 7,275 | BJDQXG4 |
| 0.06% | SVRA | SAVARA INC | -- | $52,473.60 | 9,110 | BYXGN81 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $52,136.23 | 1,307 | BKLCWZ3 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $51,834.38 | 5,462 | B8K7T65 |
| 0.06% | SEPN | SEPTERNA INC | -- | $51,608.70 | 2,005 | BQNKXX2 |
| 0.06% | PCRX | PACIRA BIOSCIENCES INC | -- | $50,114.52 | 1,926 | B3X26D8 |
| 0.06% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $49,686.00 | 3,185 | BJLKVS6 |
| 0.06% | URGN | UROGEN PHARMA LTD | -- | $49,193.12 | 2,096 | BZ7PJQ1 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $48,955.20 | 651 | BNSP8K3 |
| 0.06% | SPRY | ARS PHARMACEUTICALS INC | -- | $48,464.70 | 4,426 | BMCR7V2 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $46,390.14 | 17,774 | BF0DMK7 |
| 0.05% | XNCR | XENCOR INC | -- | $45,365.43 | 3,197 | BGCYWN8 |
| 0.05% | VTYX | VENTYX BIOSCIENCES INC | -- | $44,218.80 | 3,195 | BMG99Y1 |
| 0.05% | MESO | MESOBLAST LTD- SPON ADR | -- | $43,634.52 | 2,196 | BQS7491 |
| 0.05% | GHRS | GH RESEARCH PLC | -- | $43,182.35 | 2,777 | BP6C0S2 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $43,175.40 | 2,270 | BMNDK09 |
| 0.05% | OMER | OMEROS CORP | -- | $42,703.75 | 3,175 | B4NB858 |
| 0.05% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $42,281.75 | 4,571 | BLB0YH0 |
| 0.05% | ESPR | ESPERION THERAPEUTICS INC | -- | $41,848.73 | 10,703 | BBNBTD2 |
| 0.05% | BCAX | BICARA THERAPEUTICS INC | -- | $40,621.68 | 2,453 | BQB42F1 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $40,041.15 | 8,611 | BZ0QMB7 |
| 0.05% | ZBIO | ZENAS BIOPHARMA INC | -- | $39,433.23 | 2,403 | BQB42H3 |
| 0.04% | GERN | GERON CORP | -- | $39,157.34 | 28,582 | 2370381 |
| 0.04% | RAPT | RAPT THERAPEUTICS INC | -- | $38,719.20 | 1,241 | BTJZB49 |
| 0.04% | JANX | JANUX THERAPEUTICS INC | -- | $37,459.63 | 2,693 | BMFX8Y7 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $37,139.95 | 3,889 | BYZD465 |
| 0.04% | VIR | VIR BIOTECHNOLOGY INC | -- | $37,062.55 | 6,229 | BK4PZ38 |
| 0.04% | ORIC | ORIC PHARMACEUTICALS INC | -- | $36,850.45 | 4,361 | BKVDFF7 |
| 0.04% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $36,343.80 | 915 | BL95N25 |
| 0.04% | AVBP | ARRIVENT BIOPHARMA INC | -- | $36,257.76 | 1,848 | BMGTLY5 |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $36,178.50 | 813 | BQD3J33 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $35,816.48 | 2,264 | BD06CS0 |
| 0.04% | ARVN | ARVINAS INC | -- | $35,029.68 | 2,876 | BDZ30Q0 |
| 0.04% | ANNX | ANNEXON INC | -- | $34,279.20 | 6,480 | BMVV9R5 |
| 0.04% | RGNX | REGENXBIO INC | -- | $34,005.00 | 2,267 | BZ0G875 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $33,925.23 | 5,463 | BYVQJ96 |
| 0.04% | PSNL | PERSONALIS INC | -- | $33,265.50 | 3,972 | BJQ0608 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $32,430.50 | 1,753 | BD9GVY0 |
| 0.04% | CTMX | CYTOMX THERAPEUTICS INC | -- | $32,316.36 | 7,586 | BYWVTY5 |
| 0.04% | CMPS | COMPASS PATHWAYS PLC | -- | $32,148.78 | 4,219 | BMC3HS7 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $31,681.44 | 8,082 | BPBJFM7 |
| 0.04% | IVVD | INVIVYD INC | -- | $31,141.57 | 12,407 | BM8NHS1 |
| 0.04% | LXEO | LEXEO THERAPEUTICS INC | -- | $30,947.96 | 3,268 | BQ6C357 |
| 0.03% | CGEM | CULLINAN THERAPEUTICS INC | -- | $29,465.30 | 2,645 | BM90J52 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $28,986.34 | 7,283 | B3MZ6K5 |
| 0.03% | REPL | REPLIMUNE GROUP INC | -- | $28,903.76 | 3,512 | BDDVW37 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $27,574.68 | 13,517 | B4N8MH9 |
| 0.03% | CRMD | CORMEDIX INC | -- | $26,495.28 | 3,528 | BJ0LT31 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $26,237.12 | 3,604 | BFYQFJ2 |
| 0.03% | GOSS | GOSSAMER BIO INC | -- | $25,907.50 | 10,363 | BJ0CK86 |
| 0.03% | KROS | KEROS THERAPEUTICS INC | -- | $25,343.12 | 1,364 | BM7V485 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $25,001.90 | 6,494 | BMCWKZ2 |
| 0.03% | FULC | FULCRUM THERAPEUTICS INC | -- | $24,496.53 | 2,423 | BJDX8Z9 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $23,409.00 | 2,550 | BMFK3H6 |
| 0.03% | ABSI | ABSCI CORP | -- | $23,161.52 | 6,733 | BN94K69 |
| 0.03% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $23,140.48 | 3,344 | BYP80F1 |
| 0.03% | LYEL | LYELL IMMUNOPHARMA INC | -- | $23,085.00 | 950 | BTNMG41 |
| 0.03% | BIOA | BIOAGE LABS INC | -- | $22,355.52 | 1,606 | BT9K6D8 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $21,819.55 | 2,411 | B91XRN2 |
| 0.02% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $21,756.23 | 2,521 | BLFBZ32 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $21,704.62 | 3,206 | 2107437 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $21,377.52 | 648 | B292NQ7 |
| 0.02% | LENZ | LENZ THERAPEUTICS INC | -- | $21,351.24 | 1,401 | BQV0J03 |
| 0.02% | PEPG | PEPGEN INC | -- | $20,752.46 | 3,079 | BMTX3D7 |
| 0.02% | KMDA | KAMADA LTD | -- | $20,534.85 | 2,583 | B2Q9833 |
| 0.02% | ETON | ETON PHARMACEUTICALS INC | -- | $19,840.52 | 1,201 | BGL0JK3 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $19,421.64 | 2,646 | B12W3P6 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $19,061.76 | 4,672 | BFY7DC4 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $18,798.60 | 4,845 | BDFKQ07 |
| 0.02% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $18,680.70 | 2,559 | BKLXFX5 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $18,521.28 | 3,488 | BQHN6C7 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $17,999.72 | 1,711 | BP81RK8 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $17,983.48 | 838 | BPBPCG8 |
| 0.02% | NBP | NOVABRIDGE BIOSCIENCES | -- | $17,642.45 | 4,655 | BKRRKY7 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $17,430.73 | 7,481 | BN4JN37 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $17,364.48 | 1,292 | B9L5200 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $17,153.71 | 8,981 | BFMLGR4 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $17,080.00 | 4,000 | BYTYP72 |
| 0.02% | EOLS | EVOLUS INC | -- | $16,657.48 | 2,902 | BDRJH21 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $16,604.25 | 1,965 | BSMLR16 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $15,466.24 | 4,496 | BZC0D70 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $14,992.38 | 10,062 | BFZNYB7 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $14,669.88 | 2,843 | BP81R42 |
| 0.02% | AARD | AARDVARK THERAPEUTICS INC | -- | $14,147.25 | 975 | BTXQTX3 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $13,987.20 | 2,256 | B7F2TY6 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $13,737.36 | 2,072 | BKDQKM6 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $13,674.43 | 2,891 | BMVBZF5 |
| 0.02% | CADL | CANDEL THERAPEUTICS INC | -- | $13,641.90 | 2,458 | BP0TQC5 |
| 0.02% | MENS | JYONG BIOTECH LTD | -- | $13,616.00 | 3,404 | BPTK6Z2 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $13,242.36 | 2,532 | BMF7DT9 |
| 0.01% | LFCR | LIFECORE BIOMEDICAL INC | -- | $13,038.06 | 1,678 | 2517058 |
| 0.01% | ACRS | ACLARIS THERAPEUTICS INC | -- | $13,000.68 | 4,851 | BYV2W40 |
| 0.01% | NGNE | NEUROGENE INC | -- | $12,945.24 | 693 | BS2F741 |
| 0.01% | LRMR | LARIMAR THERAPEUTICS INC | -- | $12,875.52 | 3,832 | BMXNGZ6 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $12,627.78 | 3,498 | BLN9Z50 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $12,235.52 | 2,528 | BPRB2N7 |
| 0.01% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $12,191.60 | 2,102 | BL5B6Z1 |
| 0.01% | OABI | OMNIAB INC | -- | $12,181.05 | 6,445 | BN13S71 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $10,943.75 | 8,755 | BNR5QT9 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $10,726.52 | 2,642 | BY7RB53 |
| 0.01% | HUMA | HUMACYTE INC | -- | $9,810.45 | 8,385 | BMYTJP4 |
| 0.01% | VOR | VOR BIOPHARMA INC | -- | $9,636.12 | 754 | BRJJYT3 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $9,607.96 | 2,396 | BP7L561 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $9,504.60 | 4,340 | BKX9NQ0 |
| 0.01% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $9,481.78 | 1,034 | BPRBTY7 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $9,353.94 | 4,371 | BZ8FPH3 |
| 0.01% | CABA | CABALETTA BIO INC | -- | $9,352.70 | 4,310 | BK5MWR1 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $8,611.44 | 1,272 | BKC9SX3 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $8,280.36 | 5,412 | BRK0149 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $7,731.16 | 1,388 | BP2NYN2 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $7,091.78 | 2,551 | BKTV702 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $7,070.96 | 4,184 | BNYJR68 |
| 0.01% | CDXS | CODEXIS INC | -- | $6,795.60 | 4,045 | B5LL2C2 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $6,070.13 | 4,367 | BNNXX18 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $5,755.26 | 7,455 | BNNXX52 |
| -- | PYXS | PYXIS ONCOLOGY INC | -- | $4,042.60 | 2,788 | BLBR8D5 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $11.75 | 01 | BTFHQP5 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| 38.56% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 33,652,840 | -- | 5,795 | -- |
| 32.46% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 28,327,619 | -- | 4,878 | -- |
| 23.46% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 20,470,451 | -- | 3,525 | -- |
| 16.53% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,425,134 | -- | 2,484 | -- |
| 15.30% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 13,350,799 | -- | 2,299 | -- |
| 4.21% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,675,970 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $26,530,421.11 | 26,530,421 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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