BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 10/31/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 20.05% | 41.93% | 51.59% | 42.58% | 20.67% | 9.55% | 2.60% | 0.91% | 15.79% | 04/07/2010 |
| BIB Market Price | 20.06% | 42.12% | 51.73% | 42.51% | 20.92% | 9.51% | 2.55% | 0.91% | 15.79% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/09/2025- NAV $77.83
- NAV Change $-2.82
- Market Price $77.80
- Market Price Change $-2.80
- Trading Volume (M) 30,472
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/09/2025- NAV $77.83
- NAV Change $-2.82
- Market Price $77.80
- Market Price Change $-2.80
- Trading Volume (M) 30,472
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 12/09/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.30% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $4,374,470.10 | 10,010 | 2931034 |
| 5.18% | AMGN | AMGEN INC | -- | $4,269,615.40 | 13,604 | 2023607 |
| 5.01% | GILD | GILEAD SCIENCES INC | -- | $4,135,824.00 | 34,650 | 2369174 |
| 4.10% | REGN | REGENERON PHARMACEUTICALS | -- | $3,384,638.46 | 4,887 | 2730190 |
| 3.09% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,553,126.29 | 6,149 | B00FWN1 |
| 2.67% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $2,199,961.26 | 24,493 | 2989044 |
| 2.35% | INSM | INSMED INC | -- | $1,941,505.83 | 9,999 | 2614487 |
| 1.56% | ARGX | ARGENX SE - ADR | -- | $1,286,976.27 | 1,447 | BDVLM39 |
| 1.48% | BIIB | BIOGEN INC | -- | $1,219,450.40 | 6,935 | 2455965 |
| 1.24% | UTHR | UNITED THERAPEUTICS CORP | -- | $1,018,934.04 | 2,139 | 2430412 |
| 1.16% | ILMN | ILLUMINA INC | -- | $960,585.10 | 7,270 | 2613990 |
| 1.07% | INCY | INCYTE CORP | -- | $878,897.76 | 9,236 | 2471950 |
| 0.94% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $778,826.23 | 20,447 | BMVP7Y0 |
| 0.88% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $727,043.80 | 4,690 | 2623911 |
| 0.88% | MEDP | MEDPACE HOLDINGS INC | -- | $723,082.32 | 1,329 | BDCBC61 |
| 0.83% | RVMD | REVOLUTION MEDICINES INC | -- | $687,996.02 | 8,842 | BL71K91 |
| 0.80% | ROIV | ROIVANT SCIENCES LTD | -- | $659,889.00 | 32,300 | BMW4NZ9 |
| 0.79% | BBIO | BRIDGEBIO PHARMA INC | -- | $647,968.47 | 9,041 | BK1KWG8 |
| 0.75% | VTRS | VIATRIS INC | -- | $617,061.36 | 55,144 | BMWS3X9 |
| 0.74% | GH | GUARDANT HEALTH INC | -- | $608,835.79 | 5,899 | BFXC911 |
| 0.74% | SNY | SANOFI-ADR | -- | $607,106.19 | 12,693 | 2964557 |
| 0.73% | TEM | TEMPUS AI INC | -- | $605,370.64 | 7,978 | BSLSJJ0 |
| 0.72% | SMMT | SUMMIT THERAPEUTICS INC | -- | $598,014.72 | 35,136 | BMTVQS7 |
| 0.72% | IONS | IONIS PHARMACEUTICALS INC | -- | $594,446.68 | 7,538 | BDJ0LS6 |
| 0.71% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $585,493.44 | 1,057 | BD59BS7 |
| 0.68% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $564,524.73 | 2,871 | BV9G6B8 |
| 0.65% | EXEL | EXELIXIS INC | -- | $533,088.84 | 12,732 | 2576941 |
| 0.63% | MRNA | MODERNA INC | -- | $519,700.72 | 18,403 | BGSXTS3 |
| 0.61% | ONC | BEONE MEDICINES LTD-ADR | -- | $506,717.10 | 1,590 | BYYWPW6 |
| 0.59% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $487,959.20 | 9,080 | 2437071 |
| 0.56% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $465,361.68 | 2,868 | B4Q5ZN4 |
| 0.55% | BNTX | BIONTECH SE-ADR | -- | $456,054.30 | 4,758 | BK6H543 |
| 0.55% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $450,148.20 | 6,540 | BYQBFJ8 |
| 0.53% | RNA | AVIDITY BIOSCIENCES INC | -- | $433,860.50 | 6,085 | BMWHPY1 |
| 0.42% | CYTK | CYTOKINETICS INC | -- | $348,656.00 | 5,660 | BBBSBJ5 |
| 0.42% | MRUS | MERUS NV | -- | $344,679.72 | 3,577 | BZBY005 |
| 0.42% | AXSM | AXSOME THERAPEUTICS INC | -- | $342,864.42 | 2,361 | BYZR4X4 |
| 0.41% | HALO | HALOZYME THERAPEUTICS INC | -- | $342,264.84 | 5,532 | 2975098 |
| 0.40% | NUVL | NUVALENT INC-A | -- | $331,453.86 | 3,154 | BMVBZD3 |
| 0.39% | KRYS | KRYSTAL BIOTECH INC | -- | $320,987.52 | 1,368 | BD6JX35 |
| 0.38% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $316,430.82 | 3,142 | BF2YWG4 |
| 0.36% | KYMR | KYMERA THERAPEUTICS INC | -- | $293,828.16 | 3,382 | BMPRZV5 |
| 0.33% | PTCT | PTC THERAPEUTICS INC | -- | $276,100.26 | 3,758 | B17VCN9 |
| 0.33% | PCVX | VAXCYTE INC | -- | $274,748.34 | 6,141 | BKPVGH6 |
| 0.32% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $260,543.52 | 2,942 | BDCBCD8 |
| 0.31% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $257,097.48 | 996 | BQ721R4 |
| 0.31% | COGT | COGENT BIOSCIENCES INC | -- | $254,606.24 | 6,608 | BLR6XK8 |
| 0.30% | CRSP | CRISPR THERAPEUTICS AG | -- | $244,929.76 | 4,294 | BDHF4K6 |
| 0.27% | ADMA | ADMA BIOLOGICS INC | -- | $223,482.60 | 11,287 | B9NSBM2 |
| 0.27% | ALKS | ALKERMES PLC | -- | $222,059.52 | 7,808 | B3P6D26 |
| 0.26% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $214,582.20 | 7,980 | 2713317 |
| 0.26% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $213,346.60 | 4,454 | BDD19F8 |
| 0.26% | INDV | INDIVIOR PLC | -- | $212,531.02 | 5,902 | BP0BQQ5 |
| 0.25% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $202,977.24 | 4,548 | BFZQ0L8 |
| 0.23% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $188,140.06 | 2,819 | BQS9486 |
| 0.23% | IMVT | IMMUNOVANT INC | -- | $187,633.44 | 8,244 | BJRFSB7 |
| 0.23% | ACLX | ARCELLX INC | -- | $185,813.32 | 2,623 | BPCJ1Q2 |
| 0.22% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $185,344.80 | 5,326 | BP8JSP4 |
| 0.22% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $177,814.35 | 14,855 | BFNF1D6 |
| 0.21% | TERN | TERNS PHARMACEUTICALS INC | -- | $175,941.81 | 4,133 | BMDJ0C9 |
| 0.21% | LGND | LIGAND PHARMACEUTICALS | -- | $172,264.41 | 927 | 2501578 |
| 0.20% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $168,679.68 | 5,668 | BKX9VD3 |
| 0.20% | GRAL | GRAIL INC | -- | $166,266.76 | 1,706 | BSLSSX7 |
| 0.20% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $165,491.70 | 4,559 | BJ62Z18 |
| 0.20% | VCYT | VERACYTE INC | -- | $163,128.64 | 3,721 | BFTWZY0 |
| 0.20% | APGE | APOGEE THERAPEUTICS INC | -- | $163,082.68 | 2,182 | BM9HHL5 |
| 0.19% | WVE | WAVE LIFE SCIENCES LTD | -- | $160,400.37 | 7,527 | BYZG9R0 |
| 0.19% | TARS | TARSUS PHARMACEUTICALS INC | -- | $158,781.80 | 1,996 | BMH5RL1 |
| 0.19% | XENE | XENON PHARMACEUTICALS INC | -- | $158,717.44 | 3,647 | BRJ3GY4 |
| 0.19% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $155,390.40 | 2,376 | BJDX8Y8 |
| 0.18% | IRON | DISC MEDICINE INC | -- | $150,695.96 | 1,643 | BMGJZJ8 |
| 0.18% | CGON | CG ONCOLOGY INC | -- | $150,556.18 | 3,607 | BRBCSP4 |
| 0.18% | TVTX | TRAVERE THERAPEUTICS INC | -- | $145,459.65 | 4,215 | BLFGJD5 |
| 0.17% | FOLD | AMICUS THERAPEUTICS INC | -- | $143,029.80 | 14,580 | B19FQ48 |
| 0.17% | APLS | APELLIS PHARMACEUTICALS INC | -- | $142,061.72 | 5,974 | BYTQ6X1 |
| 0.17% | IDYA | IDEAYA BIOSCIENCES INC | -- | $141,227.52 | 4,144 | BK0VHF6 |
| 0.16% | DNLI | DENALI THERAPEUTICS INC | -- | $135,988.22 | 6,917 | BD2B4V0 |
| 0.16% | VERA | VERA THERAPEUTICS INC | -- | $134,783.88 | 3,018 | BL55460 |
| 0.16% | OCUL | OCULAR THERAPEUTIX INC | -- | $131,252.55 | 8,229 | BNZB1X8 |
| 0.16% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $129,701.00 | 4,535 | BLB0YQ9 |
| 0.15% | BEAM | BEAM THERAPEUTICS INC | -- | $126,733.28 | 4,786 | BK6L288 |
| 0.15% | DYN | DYNE THERAPEUTICS INC | -- | $124,064.32 | 6,728 | BN15WD1 |
| 0.15% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $120,499.26 | 2,653 | B72ZBG4 |
| 0.14% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $116,303.22 | 4,983 | BKY5JZ8 |
| 0.14% | MLYS | MINERALYS THERAPEUTICS INC | -- | $115,185.28 | 3,136 | BP9N0G0 |
| 0.13% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $107,021.72 | 7,202 | BJ5FZ74 |
| 0.13% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $105,590.40 | 2,720 | BKSGZN7 |
| 0.12% | SRPT | SAREPTA THERAPEUTICS INC | -- | $102,491.91 | 4,623 | B8DPDT7 |
| 0.12% | IBRX | IMMUNITYBIO INC | -- | $99,253.98 | 44,709 | BNSP0B8 |
| 0.12% | AVDL | AVADEL PHARMACEUTICALS | -- | $97,855.52 | 4,592 | BDGMC59 |
| 0.12% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $96,689.78 | 6,226 | BFWLC09 |
| 0.12% | TXG | 10X GENOMICS INC-CLASS A | -- | $96,550.08 | 5,412 | BKS3RS7 |
| 0.12% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $96,411.24 | 20,212 | BM9FJ13 |
| 0.12% | SYRE | SPYRE THERAPEUTICS INC | -- | $96,223.76 | 2,857 | BQBBDY8 |
| 0.12% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $95,090.16 | 3,982 | BMX9K07 |
| 0.11% | ZYME | ZYMEWORKS INC | -- | $91,736.78 | 3,555 | BPCQZY9 |
| 0.11% | VCEL | VERICEL CORP | -- | $91,574.68 | 2,386 | BSBMN89 |
| 0.11% | TWST | TWIST BIOSCIENCE CORP | -- | $90,160.90 | 2,855 | BGKG6G7 |
| 0.10% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $86,278.68 | 3,246 | BMZ4LN0 |
| 0.10% | HROW | HARROW INC | -- | $84,647.50 | 1,750 | BHNDW86 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $84,583.84 | 2,056 | BRXB0C0 |
| 0.10% | ANIP | ANI PHARMACEUTICALS INC | -- | $83,793.42 | 1,026 | BCDWBX6 |
| 0.10% | MNKD | MANNKIND CORP | -- | $83,740.01 | 14,513 | BF081J4 |
| 0.10% | ALVO | ALVOTECH SA | -- | $82,310.24 | 14,804 | BPNTJ34 |
| 0.10% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $79,503.25 | 4,075 | BN7Q7R7 |
| 0.10% | STOK | STOKE THERAPEUTICS INC | -- | $78,978.24 | 2,592 | BJQ05Z6 |
| 0.09% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $75,865.20 | 9,930 | 2100362 |
| 0.09% | TRVI | TREVI THERAPEUTICS INC | -- | $74,822.40 | 5,760 | BJH9ZN0 |
| 0.09% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $73,944.90 | 2,754 | BCBVTX1 |
| 0.09% | NRIX | NURIX THERAPEUTICS INC | -- | $70,653.70 | 3,614 | BMVLGP2 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $70,074.70 | 1,490 | BX7RSN3 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $69,396.16 | 1,894 | BLCD809 |
| 0.08% | TSHA | TAYSHA GENE THERAPIES INC | -- | $68,509.62 | 12,902 | BNC1BX1 |
| 0.08% | NVCR | NOVOCURE LTD | -- | $67,157.60 | 5,288 | BYSS4X4 |
| 0.08% | ARDX | ARDELYX INC | -- | $66,108.40 | 11,398 | BN89V40 |
| 0.07% | RLAY | RELAY THERAPEUTICS INC | -- | $61,807.32 | 8,154 | BN2R582 |
| 0.07% | FTRE | FORTREA HOLDINGS INC | -- | $61,790.66 | 4,294 | BRXYZ57 |
| 0.07% | INVA | INNOVIVA INC | -- | $61,736.51 | 2,981 | BDDXF67 |
| 0.07% | GMAB | GENMAB A/S -SP ADR | -- | $61,334.19 | 1,983 | BBC9WC7 |
| 0.07% | INBX | INHIBRX BIOSCIENCES INC | -- | $60,978.54 | 686 | BNSP8K3 |
| 0.07% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $60,395.94 | 5,546 | BRJZSK0 |
| 0.07% | ANAB | ANAPTYSBIO INC | -- | $58,035.00 | 1,325 | BDRW1L7 |
| 0.07% | XNCR | XENCOR INC | -- | $56,716.94 | 3,374 | BGCYWN8 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $56,404.35 | 2,199 | BNFWZS4 |
| 0.07% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $55,793.36 | 4,214 | BPCK358 |
| 0.07% | TYRA | TYRA BIOSCIENCES INC | -- | $55,764.52 | 2,521 | BMVNDH9 |
| 0.07% | EYPT | EYEPOINT PHARMACEUTICALS INC | -- | $55,680.80 | 3,260 | BMGS7L1 |
| 0.07% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $54,591.49 | 2,801 | BMFD115 |
| 0.07% | ORKA | ORUKA THERAPEUTICS INC | -- | $54,529.09 | 1,771 | BKVF0J2 |
| 0.07% | QURE | UNIQURE NV | -- | $53,924.10 | 2,595 | BJFSR88 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $53,542.38 | 7,638 | BLR7H87 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $53,226.60 | 12,236 | BMFJJ97 |
| 0.06% | SVRA | SAVARA INC | -- | $52,735.20 | 8,176 | BYXGN81 |
| 0.06% | PCRX | PACIRA BIOSCIENCES INC | -- | $52,636.25 | 2,125 | B3X26D8 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $52,440.75 | 1,371 | BKLCWZ3 |
| 0.06% | ALMS | ALUMIS INC | -- | $52,372.26 | 4,582 | BPLQG36 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $52,013.12 | 14,134 | BL53SR3 |
| 0.06% | NVAX | NOVAVAX INC | -- | $51,162.12 | 7,682 | BJDQXG4 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $50,891.40 | 5,770 | B8K7T65 |
| 0.06% | URGN | UROGEN PHARMA LTD | -- | $49,690.30 | 2,189 | BZ7PJQ1 |
| 0.06% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $49,627.79 | 2,921 | BP7KZP7 |
| 0.06% | RAPP | RAPPORT THERAPEUTICS INC | -- | $49,478.55 | 1,727 | BR3T9B6 |
| 0.06% | PGEN | PRECIGEN INC | -- | $49,466.43 | 14,093 | BKM5C84 |
| 0.06% | TNGX | TANGO THERAPEUTICS INC | -- | $47,998.56 | 5,263 | BP2P6L0 |
| 0.06% | AVBP | ARRIVENT BIOPHARMA INC | -- | $47,777.38 | 1,918 | BMGTLY5 |
| 0.06% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $47,674.55 | 3,355 | BJLKVS6 |
| 0.06% | NTLA | INTELLIA THERAPEUTICS INC | -- | $47,216.10 | 5,077 | BYZM6C2 |
| 0.06% | ORIC | ORIC PHARMACEUTICALS INC | -- | $46,573.02 | 4,593 | BKVDFF7 |
| 0.06% | SPRY | ARS PHARMACEUTICALS INC | -- | $46,412.82 | 4,674 | BMCR7V2 |
| 0.06% | ARVN | ARVINAS INC | -- | $45,496.30 | 3,473 | BDZ30Q0 |
| 0.05% | MNMD | MIND MEDICINE MINDMED INC | -- | $45,075.00 | 3,606 | BPQYY97 |
| 0.05% | JANX | JANUX THERAPEUTICS INC | -- | $44,733.08 | 2,842 | BMFX8Y7 |
| 0.05% | ERAS | ERASCA INC | -- | $44,276.10 | 13,417 | BNLYBF3 |
| 0.05% | KURA | KURA ONCOLOGY INC | -- | $43,800.35 | 4,105 | BYZD465 |
| 0.05% | VIR | VIR BIOTECHNOLOGY INC | -- | $43,756.20 | 6,570 | BK4PZ38 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $42,423.42 | 2,382 | BMNDK09 |
| 0.05% | ZLAB | ZAI LAB LTD-ADR | -- | $42,299.40 | 2,262 | BD9GVY0 |
| 0.05% | MESO | MESOBLAST LTD- SPON ADR | -- | $41,891.08 | 2,233 | BQS7491 |
| 0.05% | KROS | KEROS THERAPEUTICS INC | -- | $41,337.60 | 1,920 | BM7V485 |
| 0.05% | CRMD | CORMEDIX INC | -- | $41,030.22 | 3,531 | BJ0LT31 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $40,438.82 | 9,067 | BZ0QMB7 |
| 0.05% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $39,963.00 | 4,844 | BLB0YH0 |
| 0.05% | PSNL | PERSONALIS INC | -- | $38,836.44 | 4,194 | BJQ0608 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $38,511.00 | 17,116 | BF0DMK7 |
| 0.05% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $38,476.96 | 2,381 | BD06CS0 |
| 0.05% | REPL | REPLIMUNE GROUP INC | -- | $38,027.60 | 3,692 | BDDVW37 |
| 0.04% | GERN | GERON CORP | -- | $37,117.71 | 30,177 | 2370381 |
| 0.04% | OMER | OMEROS CORP | -- | $36,921.93 | 3,219 | B4NB858 |
| 0.04% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $36,863.64 | 963 | BL95N25 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $36,145.23 | 9,537 | BBNBTD2 |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $35,938.17 | 849 | BQD3J33 |
| 0.04% | LENZ | LENZ THERAPEUTICS INC | -- | $35,681.05 | 1,349 | BQV0J03 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $34,898.10 | 5,721 | BYVQJ96 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $34,655.49 | 8,271 | BPBJFM7 |
| 0.04% | ATXS | ASTRIA THERAPEUTICS INC | -- | $34,576.50 | 2,670 | BMYRFN8 |
| 0.04% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $34,523.01 | 14,207 | B4N8MH9 |
| 0.04% | CGEM | CULLINAN THERAPEUTICS INC | -- | $34,521.48 | 2,793 | BM90J52 |
| 0.04% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $32,114.20 | 3,805 | BFYQFJ2 |
| 0.04% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $30,561.75 | 3,525 | BYP80F1 |
| 0.04% | RGNX | REGENXBIO INC | -- | $30,502.56 | 2,398 | BZ0G875 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $27,732.02 | 7,682 | B3MZ6K5 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $27,589.68 | 4,338 | BMC3HS7 |
| 0.03% | LYEL | LYELL IMMUNOPHARMA INC | -- | $26,635.70 | 910 | BTNMG41 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $26,274.72 | 2,546 | B91XRN2 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $25,254.36 | 6,844 | BMCWKZ2 |
| 0.03% | ANNX | ANNEXON INC | -- | $25,233.12 | 5,192 | BMVV9R5 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $24,964.11 | 2,693 | BMFK3H6 |
| 0.03% | ABSI | ABSCI CORP | -- | $24,896.96 | 7,073 | BN94K69 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $24,288.54 | 2,554 | BQ6C357 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $23,216.59 | 2,209 | BKLXFX5 |
| 0.03% | ALT | ALTIMMUNE INC | -- | $23,046.00 | 4,175 | BFY7DC4 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $22,788.48 | 2,656 | BLFBZ32 |
| 0.03% | LXRX | LEXICON PHARMACEUTICALS INC | -- | $22,517.59 | 17,189 | BWFZX59 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $21,445.14 | 678 | B292NQ7 |
| 0.03% | EOLS | EVOLUS INC | -- | $21,358.80 | 3,060 | BDRJH21 |
| 0.03% | SLDB | SOLID BIOSCIENCES INC | -- | $21,183.00 | 3,684 | BQHN6C7 |
| 0.03% | SIGA | SIGA TECHNOLOGIES INC | -- | $21,168.75 | 3,387 | 2107437 |
| 0.02% | HCM | HUTCHMED CHINA-ADR | -- | $20,140.96 | 1,468 | BYXV9H7 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $19,062.00 | 1,800 | BP81RK8 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $18,656.30 | 2,938 | BP81R42 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $17,913.42 | 4,062 | BYTYP72 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $17,434.50 | 885 | BPBPCG8 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $17,149.44 | 5,104 | BDFKQ07 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $16,931.64 | 2,794 | B12W3P6 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $16,313.44 | 4,048 | BMXNGZ6 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $16,183.86 | 2,046 | BSMLR16 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $15,894.50 | 7,660 | BN4JN37 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $15,484.56 | 2,184 | BKDQKM6 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $14,902.90 | 10,495 | BFZNYB7 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $14,815.68 | 1,012 | B9L5200 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $14,134.14 | 9,486 | BFMLGR4 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $13,857.00 | 2,235 | BL5B6Z1 |
| 0.02% | AMRN | AMARIN CORP PLC -ADR | -- | $13,456.36 | 953 | BN72KB0 |
| 0.02% | NGNE | NEUROGENE INC | -- | $13,344.24 | 676 | BS2F741 |
| 0.02% | PYXS | PYXIS ONCOLOGY INC | -- | $12,611.90 | 2,933 | BLBR8D5 |
| 0.01% | ACIU | AC IMMUNE SA | -- | $11,986.26 | 4,719 | BZC0D70 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $11,787.56 | 3,754 | BLN9Z50 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $11,693.22 | 2,531 | BP7L561 |
| 0.01% | FHTX | FOGHORN THERAPEUTICS INC | -- | $11,685.38 | 2,674 | BMF7DT9 |
| 0.01% | OABI | OMNIAB INC | -- | $11,547.97 | 5,803 | BN13S71 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $11,252.67 | 2,623 | BY7RB53 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $10,377.32 | 4,253 | BZ8FPH3 |
| 0.01% | RNAC | CARTESIAN THERAPEUTICS INC | -- | $9,724.90 | 1,231 | BQB9HM8 |
| 0.01% | HUMA | HUMACYTE INC | -- | $9,513.57 | 7,491 | BMYTJP4 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $9,244.80 | 1,284 | BKC9SX3 |
| 0.01% | PEPG | PEPGEN INC | -- | $8,846.40 | 1,552 | BMTX3D7 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $8,720.53 | 3,367 | BKX9NQ0 |
| 0.01% | CDXS | CODEXIS INC | -- | $7,961.69 | 4,269 | B5LL2C2 |
| 0.01% | MXCT | MAXCYTE INC | -- | $7,766.22 | 5,043 | BKMQF66 |
| 0.01% | MRSN | MERSANA THERAPEUTICS INC | -- | $6,641.04 | 236 | BVPKH99 |
| 0.01% | NKTX | NKARTA INC | -- | $6,384.00 | 3,360 | BK80YJ8 |
| 0.01% | ALEC | ALECTOR INC | -- | $6,128.64 | 4,788 | BJ4LDC4 |
| 0.01% | CLYM | CLIMB BIO INC | -- | $6,091.40 | 3,206 | BMW5LX6 |
| 0.01% | FATE | FATE THERAPEUTICS INC | -- | $5,727.75 | 5,455 | BCZS820 |
| 0.01% | TVGN | TEVOGEN BIO HOLDINGS INC | -- | $4,196.10 | 9,304 | BPG5P75 |
| 0.01% | MGNX | MACROGENICS INC | -- | $4,156.10 | 2,990 | BFDV8K0 |
| -- | BMEA | BIOMEA FUSION INC | -- | $3,772.10 | 2,815 | BNKF6N0 |
| -- | ACRV | ACRIVON THERAPEUTICS INC | -- | $3,705.12 | 1,488 | BP2TPK4 |
| -- | PLRX | PLIANT THERAPEUTICS INC | -- | $3,659.04 | 2,904 | BMDWW66 |
| -- | ARTV | ARTIVA BIOTHERAPEUTICS INC | -- | $3,606.72 | 1,156 | BMF1LJ7 |
| -- | -- | SUTRO BIOPHARMA INC COMMON STOCK USD 0.001 | -- | $3,396.00 | 400 | -- |
| -- | TCRX | TSCAN THERAPEUTICS INC | -- | $2,518.22 | 2,481 | BNLYBJ7 |
| -- | OKUR | ONKURE THERAPEUTICS INC-A | -- | $2,024.64 | 608 | BT7KGT6 |
| -- | QTTB | Q32 BIO INC | -- | $1,866.24 | 576 | BS2FKQ4 |
| -- | APLT | APPLIED THERAPEUTICS INC | -- | $1,706.16 | 6,811 | BJL38Z1 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 34.13% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 28,156,979 | -- | 5,008 | -- |
| 32.27% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 26,622,064 | -- | 4,735 | -- |
| 26.56% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 21,910,493 | -- | 3,897 | -- |
| 16.93% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 13,966,042 | -- | 2,484 | -- |
| 15.67% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 12,925,898 | -- | 2,299 | -- |
| 4.31% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,558,979 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $24,682,422.61 | 24,682,423 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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