BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 10/31/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 20.05% | 41.93% | 51.59% | 42.58% | 20.67% | 9.55% | 2.60% | 0.91% | 15.79% | 04/07/2010 |
| BIB Market Price | 20.06% | 42.12% | 51.73% | 42.51% | 20.92% | 9.51% | 2.55% | 0.91% | 15.79% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/04/2025- NAV $81.92
- NAV Change $-0.01
- Market Price $81.87
- Market Price Change $-0.09
- Trading Volume (M) 12,733
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/04/2025- NAV $81.92
- NAV Change $-0.01
- Market Price $81.87
- Market Price Change $-0.09
- Trading Volume (M) 12,733
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 12/03/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.41% | AMGN | AMGEN INC | -- | $4,699,093.68 | 13,604 | 2023607 |
| 5.34% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $4,635,931.30 | 10,010 | 2931034 |
| 4.99% | GILD | GILEAD SCIENCES INC | -- | $4,331,250.00 | 34,650 | 2369174 |
| 4.07% | REGN | REGENERON PHARMACEUTICALS | -- | $3,536,575.29 | 4,887 | 2730190 |
| 3.35% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,910,260.21 | 6,149 | B00FWN1 |
| 2.56% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $2,225,189.05 | 24,493 | 2989044 |
| 2.38% | INSM | INSMED INC | -- | $2,067,593.22 | 9,999 | 2614487 |
| 1.54% | ARGX | ARGENX SE - ADR | -- | $1,333,844.60 | 1,447 | BDVLM39 |
| 1.44% | BIIB | BIOGEN INC | -- | $1,253,501.25 | 6,935 | 2455965 |
| 1.18% | UTHR | UNITED THERAPEUTICS CORP | -- | $1,028,773.44 | 2,139 | 2430412 |
| 1.08% | INCY | INCYTE CORP | -- | $937,454.00 | 9,236 | 2471950 |
| 1.07% | ILMN | ILLUMINA INC | -- | $930,196.50 | 7,270 | 2613990 |
| 0.93% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $809,701.20 | 20,447 | BMVP7Y0 |
| 0.88% | MEDP | MEDPACE HOLDINGS INC | -- | $766,155.21 | 1,329 | BDCBC61 |
| 0.82% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $712,692.40 | 4,690 | 2623911 |
| 0.79% | RVMD | REVOLUTION MEDICINES INC | -- | $686,934.98 | 8,842 | BL71K91 |
| 0.77% | BBIO | BRIDGEBIO PHARMA INC | -- | $670,390.15 | 9,041 | BK1KWG8 |
| 0.77% | ROIV | ROIVANT SCIENCES LTD | -- | $668,610.00 | 32,300 | BMW4NZ9 |
| 0.74% | SMMT | SUMMIT THERAPEUTICS INC | -- | $645,448.32 | 35,136 | BMTVQS7 |
| 0.73% | SNY | SANOFI-ADR | -- | $630,715.17 | 12,693 | 2964557 |
| 0.72% | GH | GUARDANT HEALTH INC | -- | $625,058.04 | 5,899 | BFXC911 |
| 0.71% | IONS | IONIS PHARMACEUTICALS INC | -- | $616,909.92 | 7,538 | BDJ0LS6 |
| 0.71% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $612,943.73 | 1,057 | BD59BS7 |
| 0.69% | VTRS | VIATRIS INC | -- | $597,760.96 | 55,144 | BMWS3X9 |
| 0.69% | TEM | TEMPUS AI INC | -- | $597,631.98 | 7,978 | BSLSJJ0 |
| 0.66% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $575,635.50 | 2,871 | BV9G6B8 |
| 0.65% | EXEL | EXELIXIS INC | -- | $560,335.32 | 12,732 | 2576941 |
| 0.62% | ONC | BEONE MEDICINES LTD-ADR | -- | $537,197.40 | 1,590 | BYYWPW6 |
| 0.57% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $493,134.80 | 9,080 | 2437071 |
| 0.55% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $479,242.80 | 2,868 | B4Q5ZN4 |
| 0.53% | MRNA | MODERNA INC | -- | $463,387.54 | 18,403 | BGSXTS3 |
| 0.53% | BNTX | BIONTECH SE-ADR | -- | $460,241.34 | 4,758 | BK6H543 |
| 0.50% | RNA | AVIDITY BIOSCIENCES INC | -- | $435,564.30 | 6,085 | BMWHPY1 |
| 0.49% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $425,590.50 | 6,540 | BYQBFJ8 |
| 0.42% | CYTK | CYTOKINETICS INC | -- | $365,975.60 | 5,660 | BBBSBJ5 |
| 0.41% | HALO | HALOZYME THERAPEUTICS INC | -- | $357,699.12 | 5,532 | 2975098 |
| 0.40% | AXSM | AXSOME THERAPEUTICS INC | -- | $348,979.41 | 2,361 | BYZR4X4 |
| 0.40% | MRUS | MERUS NV | -- | $343,821.24 | 3,577 | BZBY005 |
| 0.39% | NUVL | NUVALENT INC-A | -- | $337,162.60 | 3,154 | BMVBZD3 |
| 0.38% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $328,747.46 | 3,142 | BF2YWG4 |
| 0.34% | KRYS | KRYSTAL BIOTECH INC | -- | $297,485.28 | 1,368 | BD6JX35 |
| 0.34% | PCVX | VAXCYTE INC | -- | $292,925.70 | 6,141 | BKPVGH6 |
| 0.33% | PTCT | PTC THERAPEUTICS INC | -- | $284,706.08 | 3,758 | B17VCN9 |
| 0.30% | COGT | COGENT BIOSCIENCES INC | -- | $258,769.28 | 6,608 | BLR6XK8 |
| 0.29% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $253,217.94 | 2,942 | BDCBCD8 |
| 0.28% | CRSP | CRISPR THERAPEUTICS AG | -- | $240,421.06 | 4,294 | BDHF4K6 |
| 0.27% | ALKS | ALKERMES PLC | -- | $230,570.24 | 7,808 | B3P6D26 |
| 0.26% | KYMR | KYMERA THERAPEUTICS INC | -- | $223,178.18 | 3,382 | BMPRZV5 |
| 0.26% | ADMA | ADMA BIOLOGICS INC | -- | $222,579.64 | 11,287 | B9NSBM2 |
| 0.24% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $209,248.92 | 4,454 | BDD19F8 |
| 0.24% | AKRO | AKERO THERAPEUTICS INC | -- | $206,946.96 | 3,784 | BK7Y2V9 |
| 0.24% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $206,522.40 | 7,980 | 2713317 |
| 0.23% | INDV | INDIVIOR PLC | -- | $200,786.04 | 5,902 | BP0BQQ5 |
| 0.23% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $197,883.48 | 4,548 | BFZQ0L8 |
| 0.22% | ACLX | ARCELLX INC | -- | $191,321.62 | 2,623 | BPCJ1Q2 |
| 0.22% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $189,179.52 | 5,326 | BP8JSP4 |
| 0.22% | IMVT | IMMUNOVANT INC | -- | $187,221.24 | 8,244 | BJRFSB7 |
| 0.21% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $185,405.40 | 996 | BQ721R4 |
| 0.21% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $180,933.90 | 14,855 | BFNF1D6 |
| 0.21% | LGND | LIGAND PHARMACEUTICALS | -- | $178,938.81 | 927 | 2501578 |
| 0.20% | VCYT | VERACYTE INC | -- | $177,677.75 | 3,721 | BFTWZY0 |
| 0.20% | GRAL | GRAIL INC | -- | $172,630.14 | 1,706 | BSLSSX7 |
| 0.20% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $169,813.28 | 5,668 | BKX9VD3 |
| 0.19% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $168,672.24 | 2,376 | BJDX8Y8 |
| 0.19% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $166,175.55 | 4,559 | BJ62Z18 |
| 0.19% | TARS | TARSUS PHARMACEUTICALS INC | -- | $163,432.48 | 1,996 | BMH5RL1 |
| 0.19% | APGE | APOGEE THERAPEUTICS INC | -- | $162,668.10 | 2,182 | BM9HHL5 |
| 0.19% | XENE | XENON PHARMACEUTICALS INC | -- | $161,525.63 | 3,647 | BRJ3GY4 |
| 0.18% | CGON | CG ONCOLOGY INC | -- | $153,694.27 | 3,607 | BRBCSP4 |
| 0.17% | IRON | DISC MEDICINE INC | -- | $151,780.34 | 1,643 | BMGJZJ8 |
| 0.17% | TVTX | TRAVERE THERAPEUTICS INC | -- | $146,892.75 | 4,215 | BLFGJD5 |
| 0.16% | FOLD | AMICUS THERAPEUTICS INC | -- | $142,592.40 | 14,580 | B19FQ48 |
| 0.16% | IDYA | IDEAYA BIOSCIENCES INC | -- | $142,304.96 | 4,144 | BK0VHF6 |
| 0.16% | DYN | DYNE THERAPEUTICS INC | -- | $135,165.52 | 6,728 | BN15WD1 |
| 0.15% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $131,832.45 | 4,535 | BLB0YQ9 |
| 0.15% | DNLI | DENALI THERAPEUTICS INC | -- | $131,423.00 | 6,917 | BD2B4V0 |
| 0.15% | BEAM | BEAM THERAPEUTICS INC | -- | $127,977.64 | 4,786 | BK6L288 |
| 0.15% | APLS | APELLIS PHARMACEUTICALS INC | -- | $126,947.50 | 5,974 | BYTQ6X1 |
| 0.14% | VERA | VERA THERAPEUTICS INC | -- | $124,522.68 | 3,018 | BL55460 |
| 0.14% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $123,370.26 | 7,202 | BJ5FZ74 |
| 0.14% | MLYS | MINERALYS THERAPEUTICS INC | -- | $122,931.20 | 3,136 | BP9N0G0 |
| 0.14% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $118,748.28 | 2,653 | B72ZBG4 |
| 0.13% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $116,203.56 | 4,983 | BKY5JZ8 |
| 0.13% | TERN | TERNS PHARMACEUTICALS INC | -- | $113,616.17 | 4,133 | BMDJ0C9 |
| 0.13% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $110,500.50 | 3,982 | BMX9K07 |
| 0.12% | SRPT | SAREPTA THERAPEUTICS INC | -- | $100,966.32 | 4,623 | B8DPDT7 |
| 0.12% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $100,640.00 | 2,720 | BKSGZN7 |
| 0.11% | IBRX | IMMUNITYBIO INC | -- | $98,359.80 | 44,709 | BNSP0B8 |
| 0.11% | AVDL | AVADEL PHARMACEUTICALS | -- | $98,085.12 | 4,592 | BDGMC59 |
| 0.11% | TXG | 10X GENOMICS INC-CLASS A | -- | $96,712.44 | 5,412 | BKS3RS7 |
| 0.11% | OCUL | OCULAR THERAPEUTIX INC | -- | $94,304.34 | 8,229 | BNZB1X8 |
| 0.11% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $94,187.92 | 20,212 | BM9FJ13 |
| 0.11% | ZYME | ZYMEWORKS INC | -- | $93,212.10 | 3,555 | BPCQZY9 |
| 0.11% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $92,829.66 | 6,226 | BFWLC09 |
| 0.11% | SYRE | SPYRE THERAPEUTICS INC | -- | $91,995.40 | 2,857 | BQBBDY8 |
| 0.10% | VCEL | VERICEL CORP | -- | $89,212.54 | 2,386 | BSBMN89 |
| 0.10% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $89,136.78 | 2,819 | BQS9486 |
| 0.10% | TWST | TWIST BIOSCIENCE CORP | -- | $88,990.35 | 2,855 | BGKG6G7 |
| 0.10% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $88,453.50 | 3,246 | BMZ4LN0 |
| 0.10% | ANIP | ANI PHARMACEUTICALS INC | -- | $84,819.42 | 1,026 | BCDWBX6 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $83,453.04 | 2,056 | BRXB0C0 |
| 0.09% | MNKD | MANNKIND CORP | -- | $81,127.67 | 14,513 | BF081J4 |
| 0.09% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $80,318.25 | 4,075 | BN7Q7R7 |
| 0.09% | STOK | STOKE THERAPEUTICS INC | -- | $80,248.32 | 2,592 | BJQ05Z6 |
| 0.09% | TRVI | TREVI THERAPEUTICS INC | -- | $78,912.00 | 5,760 | BJH9ZN0 |
| 0.09% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $77,950.50 | 9,930 | 2100362 |
| 0.09% | HROW | HARROW INC | -- | $77,910.00 | 1,750 | BHNDW86 |
| 0.09% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $75,707.46 | 2,754 | BCBVTX1 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $71,744.72 | 1,894 | BLCD809 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $71,296.50 | 1,490 | BX7RSN3 |
| 0.08% | ALVO | ALVOTECH SA | -- | $68,690.56 | 14,804 | BPNTJ34 |
| 0.08% | QURE | UNIQURE NV | -- | $66,120.60 | 2,595 | BJFSR88 |
| 0.08% | ARDX | ARDELYX INC | -- | $65,766.46 | 11,398 | BN89V40 |
| 0.07% | RLAY | RELAY THERAPEUTICS INC | -- | $63,845.82 | 8,154 | BN2R582 |
| 0.07% | GMAB | GENMAB A/S -SP ADR | -- | $62,821.44 | 1,983 | BBC9WC7 |
| 0.07% | FTRE | FORTREA HOLDINGS INC | -- | $62,606.52 | 4,294 | BRXYZ57 |
| 0.07% | NVCR | NOVOCURE LTD | -- | $62,451.28 | 5,288 | BYSS4X4 |
| 0.07% | INVA | INNOVIVA INC | -- | $62,183.66 | 2,981 | BDDXF67 |
| 0.07% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $60,839.62 | 5,546 | BRJZSK0 |
| 0.07% | NRIX | NURIX THERAPEUTICS INC | -- | $60,823.62 | 3,614 | BMVLGP2 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $60,648.42 | 2,199 | BNFWZS4 |
| 0.07% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $59,880.94 | 4,214 | BPCK358 |
| 0.07% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $58,821.00 | 2,801 | BMFD115 |
| 0.07% | XNCR | XENCOR INC | -- | $58,403.94 | 3,374 | BGCYWN8 |
| 0.07% | ANAB | ANAPTYSBIO INC | -- | $57,982.00 | 1,325 | BDRW1L7 |
| 0.07% | TSHA | TAYSHA GENE THERAPIES INC | -- | $57,929.98 | 12,902 | BNC1BX1 |
| 0.07% | INBX | INHIBRX BIOSCIENCES INC | -- | $56,910.56 | 686 | BNSP8K3 |
| 0.06% | TYRA | TYRA BIOSCIENCES INC | -- | $54,705.70 | 2,521 | BMVNDH9 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $54,694.92 | 12,236 | BMFJJ97 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $54,031.11 | 1,371 | BKLCWZ3 |
| 0.06% | WVE | WAVE LIFE SCIENCES LTD | -- | $53,742.78 | 7,527 | BYZG9R0 |
| 0.06% | URGN | UROGEN PHARMA LTD | -- | $53,302.15 | 2,189 | BZ7PJQ1 |
| 0.06% | NVAX | NOVAVAX INC | -- | $52,544.88 | 7,682 | BJDQXG4 |
| 0.06% | ORKA | ORUKA THERAPEUTICS INC | -- | $52,421.60 | 1,771 | BKVF0J2 |
| 0.06% | SVRA | SAVARA INC | -- | $51,508.80 | 8,176 | BYXGN81 |
| 0.06% | PCRX | PACIRA BIOSCIENCES INC | -- | $51,403.75 | 2,125 | B3X26D8 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $51,403.74 | 7,638 | BLR7H87 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $50,660.60 | 5,770 | B8K7T65 |
| 0.06% | ORIC | ORIC PHARMACEUTICALS INC | -- | $50,431.14 | 4,593 | BKVDFF7 |
| 0.06% | TNGX | TANGO THERAPEUTICS INC | -- | $50,366.91 | 5,263 | BP2P6L0 |
| 0.06% | PGEN | PRECIGEN INC | -- | $50,312.01 | 14,093 | BKM5C84 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $49,327.66 | 14,134 | BL53SR3 |
| 0.06% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $49,248.06 | 2,921 | BP7KZP7 |
| 0.06% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $49,217.85 | 3,355 | BJLKVS6 |
| 0.06% | KURA | KURA ONCOLOGY INC | -- | $49,136.85 | 4,105 | BYZD465 |
| 0.06% | JANX | JANUX THERAPEUTICS INC | -- | $48,626.62 | 2,842 | BMFX8Y7 |
| 0.06% | RAPP | RAPPORT THERAPEUTICS INC | -- | $47,941.52 | 1,727 | BR3T9B6 |
| 0.05% | EYPT | EYEPOINT PHARMACEUTICALS INC | -- | $47,335.20 | 3,260 | BMGS7L1 |
| 0.05% | NTLA | INTELLIA THERAPEUTICS INC | -- | $45,997.62 | 5,077 | BYZM6C2 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $44,995.98 | 2,382 | BMNDK09 |
| 0.05% | ZLAB | ZAI LAB LTD-ADR | -- | $44,674.50 | 2,262 | BD9GVY0 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $44,636.70 | 4,674 | BMCR7V2 |
| 0.05% | ERAS | ERASCA INC | -- | $44,141.93 | 13,417 | BNLYBF3 |
| 0.05% | ARVN | ARVINAS INC | -- | $44,002.91 | 3,473 | BDZ30Q0 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $43,883.84 | 1,918 | BMGTLY5 |
| 0.05% | MNMD | MIND MEDICINE MINDMED INC | -- | $43,055.64 | 3,606 | BPQYY97 |
| 0.05% | PSNL | PERSONALIS INC | -- | $42,652.98 | 4,194 | BJQ0608 |
| 0.05% | VIR | VIR BIOTECHNOLOGY INC | -- | $41,193.90 | 6,570 | BK4PZ38 |
| 0.05% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $40,253.64 | 4,844 | BLB0YH0 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $40,166.81 | 9,067 | BZ0QMB7 |
| 0.05% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $40,081.29 | 849 | BQD3J33 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $39,858.57 | 963 | BL95N25 |
| 0.04% | GERN | GERON CORP | -- | $38,324.79 | 30,177 | 2370381 |
| 0.04% | REPL | REPLIMUNE GROUP INC | -- | $38,101.44 | 3,692 | BDDVW37 |
| 0.04% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $37,826.36 | 17,116 | BF0DMK7 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $37,804.69 | 2,233 | BQS7491 |
| 0.04% | LENZ | LENZ THERAPEUTICS INC | -- | $37,772.00 | 1,349 | BQV0J03 |
| 0.04% | CRMD | CORMEDIX INC | -- | $36,439.92 | 3,531 | BJ0LT31 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $36,049.86 | 9,537 | BBNBTD2 |
| 0.04% | ALMS | ALUMIS INC | -- | $35,922.88 | 4,582 | BPLQG36 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $35,184.15 | 5,721 | BYVQJ96 |
| 0.04% | ATXS | ASTRIA THERAPEUTICS INC | -- | $34,950.30 | 2,670 | BMYRFN8 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $34,905.46 | 2,381 | BD06CS0 |
| 0.04% | KROS | KEROS THERAPEUTICS INC | -- | $34,752.00 | 1,920 | BM7V485 |
| 0.04% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $34,523.01 | 14,207 | B4N8MH9 |
| 0.04% | OMER | OMEROS CORP | -- | $34,185.78 | 3,219 | B4NB858 |
| 0.04% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $30,896.60 | 3,805 | BFYQFJ2 |
| 0.04% | RGNX | REGENXBIO INC | -- | $30,886.24 | 2,398 | BZ0G875 |
| 0.03% | PRME | PRIME MEDICINE INC | -- | $29,858.31 | 8,271 | BPBJFM7 |
| 0.03% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $29,751.00 | 3,525 | BYP80F1 |
| 0.03% | CGEM | CULLINAN THERAPEUTICS INC | -- | $29,326.50 | 2,793 | BM90J52 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $28,653.86 | 7,682 | B3MZ6K5 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $28,438.82 | 2,546 | B91XRN2 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $26,310.61 | 2,693 | BMFK3H6 |
| 0.03% | LXRX | LEXICON PHARMACEUTICALS INC | -- | $24,064.60 | 17,189 | BWFZX59 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $24,022.44 | 6,844 | BMCWKZ2 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $23,636.30 | 2,209 | BKLXFX5 |
| 0.03% | ABSI | ABSCI CORP | -- | $23,270.17 | 7,073 | BN94K69 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $23,160.32 | 2,656 | BLFBZ32 |
| 0.03% | ANNX | ANNEXON INC | -- | $22,221.76 | 5,192 | BMVV9R5 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $22,117.64 | 2,554 | BQ6C357 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $22,080.42 | 4,338 | BMC3HS7 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $21,540.06 | 678 | B292NQ7 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $21,334.25 | 4,175 | BFY7DC4 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $21,134.88 | 3,387 | 2107437 |
| 0.02% | HCM | HUTCHMED CHINA-ADR | -- | $20,933.68 | 1,468 | BYXV9H7 |
| 0.02% | EOLS | EVOLUS INC | -- | $20,655.00 | 3,060 | BDRJH21 |
| 0.02% | LYEL | LYELL IMMUNOPHARMA INC | -- | $20,302.10 | 910 | BTNMG41 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $19,119.96 | 3,684 | BQHN6C7 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $18,563.34 | 4,062 | BYTYP72 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $18,509.40 | 2,938 | BP81R42 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $18,126.00 | 1,800 | BP81RK8 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $17,894.70 | 885 | BPBPCG8 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $17,388.20 | 7,660 | BN4JN37 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $17,047.36 | 5,104 | BDFKQ07 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $15,952.40 | 10,495 | BFZNYB7 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $15,593.76 | 2,184 | BKDQKM6 |
| 0.02% | AMRN | AMARIN CORP PLC -ADR | -- | $15,524.37 | 953 | BN72KB0 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $14,724.38 | 2,794 | B12W3P6 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $14,690.28 | 2,046 | BSMLR16 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $14,410.88 | 1,012 | B9L5200 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $14,147.55 | 2,235 | BL5B6Z1 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $14,046.56 | 4,048 | BMXNGZ6 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $14,039.28 | 9,486 | BFMLGR4 |
| 0.02% | NGNE | NEUROGENE INC | -- | $13,601.12 | 676 | BS2F741 |
| 0.02% | PYXS | PYXIS ONCOLOGY INC | -- | $13,491.80 | 2,933 | BLBR8D5 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $13,449.15 | 4,719 | BZC0D70 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $12,174.11 | 2,531 | BP7L561 |
| 0.01% | FHTX | FOGHORN THERAPEUTICS INC | -- | $11,872.56 | 2,674 | BMF7DT9 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $11,599.86 | 3,754 | BLN9Z50 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $11,095.29 | 2,623 | BY7RB53 |
| 0.01% | OABI | OMNIAB INC | -- | $10,909.64 | 5,803 | BN13S71 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $10,058.35 | 4,253 | BZ8FPH3 |
| 0.01% | HUMA | HUMACYTE INC | -- | $9,663.39 | 7,491 | BMYTJP4 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $9,461.27 | 3,367 | BKX9NQ0 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $8,461.56 | 1,284 | BKC9SX3 |
| 0.01% | RNAC | CARTESIAN THERAPEUTICS INC | -- | $8,186.15 | 1,231 | BQB9HM8 |
| 0.01% | PEPG | PEPGEN INC | -- | $8,148.00 | 1,552 | BMTX3D7 |
| 0.01% | MXCT | MAXCYTE INC | -- | $7,665.36 | 5,043 | BKMQF66 |
| 0.01% | CDXS | CODEXIS INC | -- | $7,214.61 | 4,269 | B5LL2C2 |
| 0.01% | MRSN | MERSANA THERAPEUTICS INC | -- | $6,572.60 | 236 | BVPKH99 |
| 0.01% | NKTX | NKARTA INC | -- | $5,980.80 | 3,360 | BK80YJ8 |
| 0.01% | FATE | FATE THERAPEUTICS INC | -- | $5,891.40 | 5,455 | BCZS820 |
| 0.01% | CLYM | CLIMB BIO INC | -- | $5,578.44 | 3,206 | BMW5LX6 |
| 0.01% | ALEC | ALECTOR INC | -- | $5,458.32 | 4,788 | BJ4LDC4 |
| 0.01% | PLRX | PLIANT THERAPEUTICS INC | -- | $4,472.16 | 2,904 | BMDWW66 |
| -- | MGNX | MACROGENICS INC | -- | $4,186.00 | 2,990 | BFDV8K0 |
| -- | ARTV | ARTIVA BIOTHERAPEUTICS INC | -- | $4,138.48 | 1,156 | BMF1LJ7 |
| -- | TVGN | TEVOGEN BIO HOLDINGS INC | -- | $3,978.39 | 9,304 | BPG5P75 |
| -- | -- | SUTRO BIOPHARMA INC COMMON STOCK USD 0.001 | -- | $3,488.70 | 401 | -- |
| -- | ACRV | ACRIVON THERAPEUTICS INC | -- | $3,392.64 | 1,488 | BP2TPK4 |
| -- | BMEA | BIOMEA FUSION INC | -- | $2,955.75 | 2,815 | BNKF6N0 |
| -- | TCRX | TSCAN THERAPEUTICS INC | -- | $2,530.62 | 2,481 | BNLYBJ7 |
| -- | QTTB | Q32 BIO INC | -- | $2,056.32 | 576 | BS2FKQ4 |
| -- | OKUR | ONKURE THERAPEUTICS INC-A | -- | $1,592.96 | 608 | BT7KGT6 |
| -- | APLT | APPLIED THERAPEUTICS INC | -- | $1,438.48 | 6,811 | BJL38Z1 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 36.26% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 31,486,245 | -- | 5,462 | -- |
| 33.24% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 28,869,117 | -- | 5,008 | -- |
| 25.87% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 22,464,646 | -- | 3,897 | -- |
| 16.49% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,319,266 | -- | 2,484 | -- |
| 15.26% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 13,252,815 | -- | 2,299 | -- |
| 4.20% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,648,992 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $27,356,418.68 | 27,356,419 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
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