BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 11/30/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 16.90% | 51.72% | 95.62% | 66.67% | 42.59% | 11.36% | 1.61% | 2.01% | 16.86% | 04/07/2010 |
| BIB Market Price | 17.00% | 51.90% | 95.85% | 66.74% | 42.98% | 11.47% | 1.66% | 2.03% | 16.87% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/19/2025- NAV $80.93
- NAV Change $+3.70
- Market Price $80.83
- Market Price Change $+3.62
- Trading Volume (M) 11,914
- 30-Day Median Bid Ask Spread 0.26%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/19/2025- NAV $80.93
- NAV Change $+3.70
- Market Price $80.83
- Market Price Change $+3.62
- Trading Volume (M) 11,914
- 30-Day Median Bid Ask Spread 0.26%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 12/19/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.95% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,055,608.40 | 11,082 | 2931034 |
| 5.58% | GILD | GILEAD SCIENCES INC | -- | $4,744,149.30 | 38,170 | 2369174 |
| 5.36% | AMGN | AMGEN INC | -- | $4,552,546.28 | 13,906 | 2023607 |
| 4.12% | REGN | REGENERON PHARMACEUTICALS | -- | $3,503,433.52 | 4,562 | 2730190 |
| 2.77% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $2,355,991.68 | 25,788 | 2989044 |
| 2.75% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,335,342.05 | 5,835 | B00FWN1 |
| 1.94% | INSM | INSMED INC | -- | $1,646,992.80 | 9,420 | 2614487 |
| 1.33% | BIIB | BIOGEN INC | -- | $1,132,704.00 | 6,480 | 2455965 |
| 1.29% | ARGX | ARGENX SE - ADR | -- | $1,099,517.14 | 1,286 | BDVLM39 |
| 1.16% | UTHR | UNITED THERAPEUTICS CORP | -- | $983,581.26 | 1,902 | 2430412 |
| 1.07% | ILMN | ILLUMINA INC | -- | $909,630.22 | 6,749 | 2613990 |
| 1.05% | INCY | INCYTE CORP | -- | $890,424.99 | 8,671 | 2471950 |
| 0.86% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $728,420.60 | 18,871 | BMVP7Y0 |
| 0.83% | MEDP | MEDPACE HOLDINGS INC | -- | $707,039.84 | 1,244 | BDCBC61 |
| 0.81% | ROIV | ROIVANT SCIENCES LTD | -- | $688,412.79 | 30,719 | BMW4NZ9 |
| 0.79% | RVMD | REVOLUTION MEDICINES INC | -- | $672,702.42 | 8,539 | BL71K91 |
| 0.76% | BBIO | BRIDGEBIO PHARMA INC | -- | $649,465.60 | 8,512 | BK1KWG8 |
| 0.75% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $638,580.00 | 4,404 | 2623911 |
| 0.71% | VTRS | VIATRIS INC | -- | $606,664.36 | 50,852 | BMWS3X9 |
| 0.70% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $592,793.06 | 1,003 | BD59BS7 |
| 0.69% | SMMT | SUMMIT THERAPEUTICS INC | -- | $585,939.42 | 32,881 | BMTVQS7 |
| 0.69% | MRNA | MODERNA INC | -- | $583,083.80 | 17,251 | BGSXTS3 |
| 0.67% | GH | GUARDANT HEALTH INC | -- | $569,914.36 | 5,714 | BFXC911 |
| 0.67% | IONS | IONIS PHARMACEUTICALS INC | -- | $569,243.78 | 7,154 | BDJ0LS6 |
| 0.66% | SNY | SANOFI-ADR | -- | $563,127.84 | 11,688 | 2964557 |
| 0.64% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $542,372.88 | 2,712 | BV9G6B8 |
| 0.62% | EXEL | EXELIXIS INC | -- | $524,600.60 | 11,842 | 2576941 |
| 0.61% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $518,368.55 | 8,477 | 2437071 |
| 0.58% | TEM | TEMPUS AI INC | -- | $492,152.10 | 7,635 | BSLSJJ0 |
| 0.57% | RNA | AVIDITY BIOSCIENCES INC | -- | $481,422.70 | 6,655 | BMWHPY1 |
| 0.53% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $448,201.16 | 2,684 | B4Q5ZN4 |
| 0.52% | ONC | BEONE MEDICINES LTD-ADR | -- | $439,309.50 | 1,390 | BYYWPW6 |
| 0.49% | BNTX | BIONTECH SE-ADR | -- | $412,920.00 | 4,464 | BK6H543 |
| 0.48% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $408,891.84 | 5,999 | BYQBFJ8 |
| 0.42% | CYTK | CYTOKINETICS INC | -- | $358,147.97 | 5,713 | BBBSBJ5 |
| 0.41% | HALO | HALOZYME THERAPEUTICS INC | -- | $349,815.90 | 5,194 | 2975098 |
| 0.41% | -- | CARIS LIFE SCIENCES INC COMMON STOCK USD 0.001 | -- | $348,188.28 | 12,462 | -- |
| 0.40% | AXSM | AXSOME THERAPEUTICS INC | -- | $339,951.55 | 2,227 | BYZR4X4 |
| 0.39% | NUVL | NUVALENT INC-A | -- | $331,122.00 | 3,190 | BMVBZD3 |
| 0.39% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $330,588.72 | 2,948 | BF2YWG4 |
| 0.36% | KRYS | KRYSTAL BIOTECH INC | -- | $308,464.80 | 1,281 | BD6JX35 |
| 0.35% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $301,576.60 | 1,105 | BQ721R4 |
| 0.35% | -- | ABIVAX SA ADR USD 0.01 | -- | $299,648.58 | 2,607 | -- |
| 0.33% | PTCT | PTC THERAPEUTICS INC | -- | $278,609.22 | 3,546 | B17VCN9 |
| 0.32% | PCVX | VAXCYTE INC | -- | $268,586.12 | 5,786 | BKPVGH6 |
| 0.32% | COGT | COGENT BIOSCIENCES INC | -- | $268,030.35 | 6,777 | BLR6XK8 |
| 0.31% | KYMR | KYMERA THERAPEUTICS INC | -- | $266,920.22 | 3,178 | BMPRZV5 |
| 0.28% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $237,584.05 | 2,761 | BDCBCD8 |
| 0.28% | CRSP | CRISPR THERAPEUTICS AG | -- | $234,667.86 | 4,201 | BDHF4K6 |
| 0.24% | ALKS | ALKERMES PLC | -- | $207,571.20 | 7,296 | B3P6D26 |
| 0.24% | IMVT | IMMUNOVANT INC | -- | $206,503.20 | 7,740 | BJRFSB7 |
| 0.24% | ADMA | ADMA BIOLOGICS INC | -- | $205,824.96 | 10,512 | B9NSBM2 |
| 0.24% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $202,966.68 | 7,473 | 2713317 |
| 0.24% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $201,209.91 | 4,191 | BDD19F8 |
| 0.23% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $197,813.40 | 4,506 | BFZQ0L8 |
| 0.23% | INDV | INDIVIOR PLC | -- | $194,183.15 | 5,515 | BP0BQQ5 |
| 0.23% | FOLD | AMICUS THERAPEUTICS INC | -- | $193,245.04 | 13,628 | B19FQ48 |
| 0.23% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $192,027.58 | 2,957 | BQS9486 |
| 0.22% | APGE | APOGEE THERAPEUTICS INC | -- | $190,223.88 | 2,422 | BM9HHL5 |
| 0.21% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $176,469.80 | 2,270 | BJDX8Y8 |
| 0.21% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $175,830.88 | 5,008 | BP8JSP4 |
| 0.21% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $174,471.60 | 13,880 | BFNF1D6 |
| 0.20% | LGND | LIGAND PHARMACEUTICALS | -- | $174,086.77 | 869 | 2501578 |
| 0.19% | ACLX | ARCELLX INC | -- | $163,353.84 | 2,554 | BPCJ1Q2 |
| 0.19% | TERN | TERNS PHARMACEUTICALS INC | -- | $158,762.10 | 3,979 | BMDJ0C9 |
| 0.18% | GRAL | GRAIL INC | -- | $156,856.98 | 1,722 | BSLSSX7 |
| 0.18% | TARS | TARSUS PHARMACEUTICALS INC | -- | $152,625.00 | 1,875 | BMH5RL1 |
| 0.18% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $151,534.10 | 5,410 | BKX9VD3 |
| 0.18% | XENE | XENON PHARMACEUTICALS INC | -- | $150,513.30 | 3,413 | BRJ3GY4 |
| 0.18% | VCYT | VERACYTE INC | -- | $150,091.24 | 3,497 | BFTWZY0 |
| 0.17% | VERA | VERA THERAPEUTICS INC | -- | $144,645.28 | 2,824 | BL55460 |
| 0.17% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $142,743.50 | 4,261 | BJ62Z18 |
| 0.16% | CGON | CG ONCOLOGY INC | -- | $138,907.77 | 3,559 | BRBCSP4 |
| 0.16% | APLS | APELLIS PHARMACEUTICALS INC | -- | $137,744.20 | 5,588 | BYTQ6X1 |
| 0.16% | TVTX | TRAVERE THERAPEUTICS INC | -- | $136,383.52 | 3,952 | BLFGJD5 |
| 0.16% | IRON | DISC MEDICINE INC | -- | $133,426.68 | 1,667 | BMGJZJ8 |
| 0.15% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $130,398.84 | 2,533 | B72ZBG4 |
| 0.15% | IDYA | IDEAYA BIOSCIENCES INC | -- | $129,905.60 | 3,872 | BK0VHF6 |
| 0.15% | MLYS | MINERALYS THERAPEUTICS INC | -- | $128,757.68 | 3,496 | BP9N0G0 |
| 0.15% | DYN | DYNE THERAPEUTICS INC | -- | $125,213.80 | 6,308 | BN15WD1 |
| 0.14% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $119,471.80 | 4,676 | BKY5JZ8 |
| 0.14% | BEAM | BEAM THERAPEUTICS INC | -- | $119,086.74 | 4,482 | BK6L288 |
| 0.14% | OCUL | OCULAR THERAPEUTIX INC | -- | $118,139.36 | 9,406 | BNZB1X8 |
| 0.14% | WVE | WAVE LIFE SCIENCES LTD | -- | $117,996.32 | 7,384 | BYZG9R0 |
| 0.13% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $114,631.00 | 6,743 | BJ5FZ74 |
| 0.13% | SYRE | SPYRE THERAPEUTICS INC | -- | $114,461.80 | 3,427 | BQBBDY8 |
| 0.13% | DNLI | DENALI THERAPEUTICS INC | -- | $109,154.30 | 6,478 | BD2B4V0 |
| 0.12% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $105,885.85 | 4,261 | BLB0YQ9 |
| 0.11% | SRPT | SAREPTA THERAPEUTICS INC | -- | $97,141.68 | 4,617 | B8DPDT7 |
| 0.11% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $97,028.82 | 3,474 | BMZ4LN0 |
| 0.11% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $96,748.86 | 22,711 | BM9FJ13 |
| 0.11% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $96,188.64 | 2,544 | BKSGZN7 |
| 0.11% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $94,216.14 | 5,823 | BFWLC09 |
| 0.11% | IBRX | IMMUNITYBIO INC | -- | $90,490.40 | 43,505 | BNSP0B8 |
| 0.11% | ZYME | ZYMEWORKS INC | -- | $89,995.15 | 3,305 | BPCQZY9 |
| 0.10% | MAZE | MAZE THERAPEUTICS INC | -- | $88,633.75 | 2,125 | BSRK699 |
| 0.10% | TWST | TWIST BIOSCIENCE CORP | -- | $87,744.49 | 2,699 | BGKG6G7 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $86,164.05 | 1,995 | BRXB0C0 |
| 0.10% | ZBIO | ZENAS BIOPHARMA INC | -- | $85,711.65 | 2,371 | BQB42H3 |
| 0.10% | GMAB | GENMAB A/S -SP ADR | -- | $83,605.16 | 2,582 | BBC9WC7 |
| 0.10% | SION | SIONNA THERAPEUTICS INC | -- | $83,511.27 | 1,971 | BQKXDX4 |
| 0.10% | NRIX | NURIX THERAPEUTICS INC | -- | $82,914.04 | 4,477 | BMVLGP2 |
| 0.10% | TXG | 10X GENOMICS INC-CLASS A | -- | $82,593.30 | 5,146 | BKS3RS7 |
| 0.10% | ANIP | ANI PHARMACEUTICALS INC | -- | $82,187.20 | 992 | BCDWBX6 |
| 0.10% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $81,520.48 | 3,719 | BMX9K07 |
| 0.09% | STOK | STOKE THERAPEUTICS INC | -- | $80,635.08 | 2,523 | BJQ05Z6 |
| 0.09% | VCEL | VERICEL CORP | -- | $80,535.70 | 2,234 | BSBMN89 |
| 0.09% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $79,736.03 | 3,839 | BN7Q7R7 |
| 0.09% | MNKD | MANNKIND CORP | -- | $79,207.92 | 13,563 | BF081J4 |
| 0.09% | HROW | HARROW INC | -- | $75,910.40 | 1,636 | BHNDW86 |
| 0.09% | TRVI | TREVI THERAPEUTICS INC | -- | $73,688.64 | 5,664 | BJH9ZN0 |
| 0.09% | FTRE | FORTREA HOLDINGS INC | -- | $72,396.94 | 4,081 | BRXYZ57 |
| 0.09% | -- | PHARVARIS NV COMMON STOCK USD 0.12 | -- | $72,394.11 | 2,829 | -- |
| 0.08% | UPB | UPSTREAM BIO INC | -- | $70,058.45 | 2,387 | BRCFFK6 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $69,391.27 | 1,927 | BLCD809 |
| 0.08% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $68,905.59 | 9,299 | 2100362 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $68,236.48 | 1,396 | BX7RSN3 |
| 0.08% | ORKA | ORUKA THERAPEUTICS INC | -- | $68,073.92 | 2,138 | BKVF0J2 |
| 0.08% | ALVO | ALVOTECH SA | -- | $67,747.40 | 13,826 | BPNTJ34 |
| 0.08% | PGEN | PRECIGEN INC | -- | $67,361.76 | 15,593 | BKM5C84 |
| 0.08% | TSHA | TAYSHA GENE THERAPIES INC | -- | $66,423.51 | 12,099 | BNC1BX1 |
| 0.08% | INVA | INNOVIVA INC | -- | $66,026.97 | 3,303 | BDDXF67 |
| 0.08% | QURE | UNIQURE NV | -- | $65,996.49 | 2,751 | BJFSR88 |
| 0.08% | RAPP | RAPPORT THERAPEUTICS INC | -- | $65,000.95 | 2,107 | BR3T9B6 |
| 0.08% | RLAY | RELAY THERAPEUTICS INC | -- | $64,302.00 | 7,655 | BN2R582 |
| 0.08% | EYPT | EYEPOINT INC | -- | $63,741.51 | 3,657 | BMGS7L1 |
| 0.07% | ATAI | ATAI LIFE SCIENCES NV | -- | $63,526.32 | 16,042 | BN6M8F1 |
| 0.07% | NVCR | NOVOCURE LTD | -- | $63,506.64 | 4,946 | BYSS4X4 |
| 0.07% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $63,008.96 | 2,576 | BCBVTX1 |
| 0.07% | ARDX | ARDELYX INC | -- | $60,957.76 | 10,732 | BN89V40 |
| 0.07% | KOD | KODIAK SCIENCES INC | -- | $60,918.00 | 2,343 | BFXC933 |
| 0.07% | MBX | MBX BIOSCIENCES INC | -- | $60,322.86 | 1,983 | BQXJKH2 |
| 0.07% | TYRA | TYRA BIOSCIENCES INC | -- | $60,127.07 | 2,357 | BMVNDH9 |
| 0.07% | ANAB | ANAPTYSBIO INC | -- | $60,024.84 | 1,223 | BDRW1L7 |
| 0.07% | SEPN | SEPTERNA INC | -- | $58,509.24 | 1,978 | BQNKXX2 |
| 0.07% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $58,309.02 | 4,851 | BPCK358 |
| 0.07% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $56,330.82 | 5,187 | BRJZSK0 |
| 0.07% | INBX | INHIBRX BIOSCIENCES INC | -- | $55,295.46 | 642 | BNSP8K3 |
| 0.07% | MNMD | MIND MEDICINE MINDMED INC | -- | $55,257.70 | 4,351 | BPQYY97 |
| 0.06% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $55,079.26 | 3,142 | BJLKVS6 |
| 0.06% | SVRA | SAVARA INC | -- | $54,371.35 | 8,987 | BYXGN81 |
| 0.06% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $53,998.00 | 2,030 | BNFWZS4 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $53,794.86 | 7,329 | BLR7H87 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $51,295.40 | 11,765 | BMFJJ97 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $50,838.16 | 1,289 | BKLCWZ3 |
| 0.06% | TNGX | TANGO THERAPEUTICS INC | -- | $50,685.48 | 5,949 | BP2P6L0 |
| 0.06% | PCRX | PACIRA BIOSCIENCES INC | -- | $50,065.00 | 1,900 | B3X26D8 |
| 0.06% | XNCR | XENCOR INC | -- | $49,044.70 | 3,154 | BGCYWN8 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $48,599.76 | 5,388 | B8K7T65 |
| 0.06% | ALMS | ALUMIS INC | -- | $48,479.26 | 4,294 | BPLQG36 |
| 0.06% | NVAX | NOVAVAX INC | -- | $47,798.82 | 7,177 | BJDQXG4 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $47,664.00 | 13,240 | BL53SR3 |
| 0.06% | NTLA | INTELLIA THERAPEUTICS INC | -- | $47,174.53 | 5,111 | BYZM6C2 |
| 0.06% | URGN | UROGEN PHARMA LTD | -- | $47,150.40 | 2,068 | BZ7PJQ1 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $45,799.34 | 4,366 | BMCR7V2 |
| 0.05% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $44,693.04 | 2,876 | BP7KZP7 |
| 0.05% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $44,216.27 | 2,621 | BMFD115 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $43,484.32 | 17,534 | BF0DMK7 |
| 0.05% | ERAS | ERASCA INC | -- | $43,231.95 | 12,531 | BNLYBF3 |
| 0.05% | BCAX | BICARA THERAPEUTICS INC | -- | $42,592.00 | 2,420 | BQB42F1 |
| 0.05% | MESO | MESOBLAST LTD- SPON ADR | -- | $42,193.68 | 2,166 | BQS7491 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $42,070.81 | 2,239 | BMNDK09 |
| 0.05% | CRMD | CORMEDIX INC | -- | $41,829.60 | 3,480 | BJ0LT31 |
| 0.05% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $41,663.16 | 4,509 | BLB0YH0 |
| 0.05% | ESPR | ESPERION THERAPEUTICS INC | -- | $41,496.87 | 10,559 | BBNBTD2 |
| 0.05% | -- | RAPT THERAPEUTICS INC | -- | $41,383.44 | 1,224 | BTJZB49 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $40,124.23 | 1,823 | BMGTLY5 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $37,746.24 | 3,836 | BYZD465 |
| 0.04% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $37,632.85 | 8,495 | BZ0QMB7 |
| 0.04% | GERN | GERON CORP | -- | $37,500.68 | 28,196 | 2370381 |
| 0.04% | JANX | JANUX THERAPEUTICS INC | -- | $36,640.03 | 2,657 | BMFX8Y7 |
| 0.04% | -- | GH RESEARCH PLC COMMON STOCK USD 0.01 | -- | $35,510.40 | 2,740 | -- |
| 0.04% | VIR | VIR BIOTECHNOLOGY INC | -- | $35,395.20 | 6,145 | BK4PZ38 |
| 0.04% | GOSS | GOSSAMER BIO INC | -- | $35,167.12 | 10,223 | BJ0CK86 |
| 0.04% | ORIC | ORIC PHARMACEUTICALS INC | -- | $34,588.08 | 4,302 | BKVDFF7 |
| 0.04% | REPL | REPLIMUNE GROUP INC | -- | $34,234.20 | 3,465 | BDDVW37 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $34,008.59 | 2,233 | BD06CS0 |
| 0.04% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $33,636.75 | 903 | BL95N25 |
| 0.04% | PSNL | PERSONALIS INC | -- | $33,498.90 | 3,918 | BJQ0608 |
| 0.04% | LXEO | LEXEO THERAPEUTICS INC | -- | $33,368.40 | 3,224 | BQ6C357 |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $33,355.18 | 802 | BQD3J33 |
| 0.04% | ARVN | ARVINAS INC | -- | $33,136.16 | 2,837 | BDZ30Q0 |
| 0.04% | ANNX | ANNEXON INC | -- | $33,051.81 | 6,393 | BMVV9R5 |
| 0.04% | RGNX | REGENXBIO INC | -- | $32,623.24 | 2,236 | BZ0G875 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $31,256.20 | 5,389 | BYVQJ96 |
| 0.04% | LYEL | LYELL IMMUNOPHARMA INC | -- | $31,230.21 | 937 | BTNMG41 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $31,191.16 | 1,729 | BD9GVY0 |
| 0.04% | OMER | OMEROS CORP | -- | $30,067.20 | 3,132 | B4NB858 |
| 0.04% | CTMX | CYTOMX THERAPEUTICS INC | -- | $29,936.00 | 7,484 | BYWVTY5 |
| 0.03% | FULC | FULCRUM THERAPEUTICS INC | -- | $29,349.20 | 2,390 | BJDX8Z9 |
| 0.03% | PRME | PRIME MEDICINE INC | -- | $29,021.72 | 7,973 | BPBJFM7 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $28,546.65 | 3,555 | BFYQFJ2 |
| 0.03% | IVVD | INVIVYD INC | -- | $28,152.00 | 12,240 | BM8NHS1 |
| 0.03% | VTYX | VENTYX BIOSCIENCES INC | -- | $27,548.48 | 3,152 | BMG99Y1 |
| 0.03% | KROS | KEROS THERAPEUTICS INC | -- | $27,269.96 | 1,346 | BM7V485 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $26,511.94 | 4,162 | BMC3HS7 |
| 0.03% | CGEM | CULLINAN THERAPEUTICS INC | -- | $25,255.12 | 2,609 | BM90J52 |
| 0.03% | LENZ | LENZ THERAPEUTICS INC | -- | $24,876.00 | 1,382 | BQV0J03 |
| 0.03% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $24,709.51 | 3,299 | BYP80F1 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $24,536.40 | 13,335 | B4N8MH9 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $24,354.88 | 2,516 | BMFK3H6 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $22,489.05 | 7,185 | B3MZ6K5 |
| 0.03% | ABSI | ABSCI CORP | -- | $22,449.96 | 6,642 | BN94K69 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $21,972.58 | 6,406 | BMCWKZ2 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $21,908.32 | 2,524 | BKLXFX5 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $21,901.38 | 2,378 | B91XRN2 |
| 0.02% | BIOA | BIOAGE LABS INC | -- | $21,209.76 | 1,584 | BT9K6D8 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $20,678.04 | 639 | B292NQ7 |
| 0.02% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $20,666.97 | 2,487 | BLFBZ32 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $20,439.54 | 3,441 | BQHN6C7 |
| 0.02% | EOLS | EVOLUS INC | -- | $20,241.41 | 2,863 | BDRJH21 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $19,832.01 | 3,163 | 2107437 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $19,622.25 | 1,275 | B9L5200 |
| 0.02% | ETON | ETON PHARMACEUTICALS INC | -- | $19,398.45 | 1,185 | BGL0JK3 |
| 0.02% | IMAB | I-MAB-SPONSORED ADR | -- | $19,240.48 | 4,592 | BKRRKY7 |
| 0.02% | KMDA | KAMADA LTD | -- | $18,549.44 | 2,548 | B2Q9833 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $18,534.24 | 1,688 | BP81RK8 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $17,975.10 | 4,609 | BFY7DC4 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $17,617.50 | 2,610 | B12W3P6 |
| 0.02% | PEPG | PEPGEN INC | -- | $16,460.54 | 3,037 | BMTX3D7 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $16,437.30 | 2,805 | BP81R42 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $16,176.12 | 827 | BPBPCG8 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $16,113.80 | 2,852 | BMVBZF5 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $15,439.40 | 4,780 | BDFKQ07 |
| 0.02% | ACRS | ACLARIS THERAPEUTICS INC | -- | $15,028.04 | 4,786 | BYV2W40 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $14,481.82 | 3,946 | BYTYP72 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $14,441.80 | 8,860 | BFMLGR4 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $14,094.92 | 9,926 | BFZNYB7 |
| 0.02% | NGNE | NEUROGENE INC | -- | $14,056.20 | 684 | BS2F741 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $14,042.28 | 2,044 | BKDQKM6 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $13,941.41 | 1,939 | BSMLR16 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $13,797.00 | 3,780 | BMXNGZ6 |
| 0.02% | CADL | CANDEL THERAPEUTICS INC | -- | $13,507.25 | 2,425 | BP0TQC5 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $13,438.05 | 4,435 | BZC0D70 |
| 0.02% | LFCR | LIFECORE BIOMEDICAL INC | -- | $13,306.20 | 1,655 | 2517058 |
| 0.02% | OABI | OMNIAB INC | -- | $13,288.22 | 6,358 | BN13S71 |
| 0.02% | AARD | AARDVARK THERAPEUTICS INC | -- | $13,246.74 | 962 | BTXQTX3 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $13,211.38 | 2,074 | BL5B6Z1 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $13,089.52 | 2,498 | BMF7DT9 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $12,915.00 | 7,380 | BN4JN37 |
| 0.01% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $12,532.38 | 2,226 | B7F2TY6 |
| 0.01% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $11,974.80 | 1,020 | BPRBTY7 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $10,992.60 | 2,364 | BP7L561 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $10,968.99 | 8,637 | BNR5QT9 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $10,848.90 | 2,494 | BPRB2N7 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $10,836.14 | 3,451 | BLN9Z50 |
| 0.01% | -- | JYONG BIOTECH LTD COMMON STOCK USD 0.00001 | -- | $10,661.65 | 3,358 | -- |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $10,424.00 | 2,606 | BY7RB53 |
| 0.01% | CABA | CABALETTA BIO INC | -- | $10,162.28 | 4,252 | BK5MWR1 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $10,090.08 | 4,312 | BZ8FPH3 |
| 0.01% | -- | VOR BIOPHARMA INC COMMON STOCK USD 0.0001 | -- | $9,233.04 | 744 | -- |
| 0.01% | HUMA | HUMACYTE INC | -- | $9,181.92 | 8,272 | BMYTJP4 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $8,690.43 | 4,281 | BKX9NQ0 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $8,597.32 | 1,369 | BP2NYN2 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $8,195.15 | 1,255 | BKC9SX3 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $7,261.04 | 5,339 | BRK0149 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $6,935.04 | 4,128 | BNYJR68 |
| 0.01% | CDXS | CODEXIS INC | -- | $6,623.40 | 3,990 | B5LL2C2 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $6,505.08 | 4,308 | BNNXX18 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $6,393.18 | 2,517 | BKTV702 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $5,151.48 | 7,354 | BNNXX52 |
| -- | PYXS | PYXIS ONCOLOGY INC | -- | $3,506.25 | 2,750 | BLBR8D5 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 34.73% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 29,504,950 | -- | 5,142 | -- |
| 33.82% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 28,736,054 | -- | 5,008 | -- |
| 25.70% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 21,838,942 | -- | 3,806 | -- |
| 16.78% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,253,267 | -- | 2,484 | -- |
| 15.53% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 13,191,731 | -- | 2,299 | -- |
| 4.27% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,632,173 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $25,762,474.53 | 25,762,475 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
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