BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 10/31/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 20.05% | 41.93% | 51.59% | 42.58% | 20.67% | 9.55% | 2.60% | 0.91% | 15.79% | 04/07/2010 |
| BIB Market Price | 20.06% | 42.12% | 51.73% | 42.51% | 20.92% | 9.51% | 2.55% | 0.91% | 15.79% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/10/2025- NAV $79.45
- NAV Change $+1.62
- Market Price $79.43
- Market Price Change $+1.63
- Trading Volume (M) 11,860
- 30-Day Median Bid Ask Spread 0.26%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/10/2025- NAV $79.45
- NAV Change $+1.62
- Market Price $79.43
- Market Price Change $+1.63
- Trading Volume (M) 11,860
- 30-Day Median Bid Ask Spread 0.26%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 12/10/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.26% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $4,390,820.00 | 9,875 | 2931034 |
| 5.07% | AMGN | AMGEN INC | -- | $4,232,714.98 | 13,421 | 2023607 |
| 4.97% | GILD | GILEAD SCIENCES INC | -- | $4,147,886.56 | 34,184 | 2369174 |
| 4.20% | REGN | REGENERON PHARMACEUTICALS | -- | $3,501,058.41 | 4,821 | 2730190 |
| 2.94% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,453,454.36 | 6,066 | B00FWN1 |
| 2.65% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $2,211,156.13 | 24,163 | 2989044 |
| 2.24% | INSM | INSMED INC | -- | $1,872,680.40 | 9,864 | 2614487 |
| 1.52% | ARGX | ARGENX SE - ADR | -- | $1,271,077.08 | 1,428 | BDVLM39 |
| 1.46% | BIIB | BIOGEN INC | -- | $1,214,797.10 | 6,842 | 2455965 |
| 1.23% | UTHR | UNITED THERAPEUTICS CORP | -- | $1,023,054.60 | 2,110 | 2430412 |
| 1.16% | ILMN | ILLUMINA INC | -- | $967,574.52 | 7,172 | 2613990 |
| 1.04% | INCY | INCYTE CORP | -- | $867,189.04 | 9,112 | 2471950 |
| 0.93% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $771,780.72 | 20,172 | BMVP7Y0 |
| 0.88% | MEDP | MEDPACE HOLDINGS INC | -- | $735,143.25 | 1,311 | BDCBC61 |
| 0.86% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $720,100.01 | 4,627 | 2623911 |
| 0.81% | RVMD | REVOLUTION MEDICINES INC | -- | $679,347.24 | 8,723 | BL71K91 |
| 0.78% | BBIO | BRIDGEBIO PHARMA INC | -- | $648,411.30 | 8,919 | BK1KWG8 |
| 0.77% | ROIV | ROIVANT SCIENCES LTD | -- | $644,947.60 | 31,865 | BMW4NZ9 |
| 0.76% | VTRS | VIATRIS INC | -- | $631,063.20 | 54,402 | BMWS3X9 |
| 0.75% | SMMT | SUMMIT THERAPEUTICS INC | -- | $621,854.22 | 34,663 | BMTVQS7 |
| 0.72% | SNY | SANOFI-ADR | -- | $604,311.72 | 12,522 | 2964557 |
| 0.72% | GH | GUARDANT HEALTH INC | -- | $597,248.40 | 5,820 | BFXC911 |
| 0.71% | TEM | TEMPUS AI INC | -- | $590,875.97 | 7,871 | BSLSJJ0 |
| 0.70% | IONS | IONIS PHARMACEUTICALS INC | -- | $584,771.31 | 7,437 | BDJ0LS6 |
| 0.69% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $576,226.21 | 1,043 | BD59BS7 |
| 0.68% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $569,911.68 | 2,832 | BV9G6B8 |
| 0.63% | MRNA | MODERNA INC | -- | $527,039.65 | 18,155 | BGSXTS3 |
| 0.62% | EXEL | EXELIXIS INC | -- | $515,880.27 | 12,561 | 2576941 |
| 0.61% | ONC | BEONE MEDICINES LTD-ADR | -- | $506,284.92 | 1,569 | BYYWPW6 |
| 0.58% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $481,044.60 | 8,958 | 2437071 |
| 0.56% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $466,700.13 | 2,829 | B4Q5ZN4 |
| 0.54% | BNTX | BIONTECH SE-ADR | -- | $449,380.09 | 4,694 | BK6H543 |
| 0.53% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $444,349.24 | 6,452 | BYQBFJ8 |
| 0.51% | RNA | AVIDITY BIOSCIENCES INC | -- | $428,314.05 | 6,003 | BMWHPY1 |
| 0.42% | AXSM | AXSOME THERAPEUTICS INC | -- | $347,626.54 | 2,329 | BYZR4X4 |
| 0.41% | HALO | HALOZYME THERAPEUTICS INC | -- | $341,943.70 | 5,458 | 2975098 |
| 0.41% | MRUS | MERUS NV | -- | $341,501.33 | 3,529 | BZBY005 |
| 0.40% | CYTK | CYTOKINETICS INC | -- | $336,798.96 | 5,584 | BBBSBJ5 |
| 0.39% | NUVL | NUVALENT INC-A | -- | $329,062.88 | 3,112 | BMVBZD3 |
| 0.39% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $324,787.00 | 3,100 | BF2YWG4 |
| 0.39% | KRYS | KRYSTAL BIOTECH INC | -- | $323,622.00 | 1,350 | BD6JX35 |
| 0.36% | KYMR | KYMERA THERAPEUTICS INC | -- | $299,873.04 | 3,336 | BMPRZV5 |
| 0.33% | PTCT | PTC THERAPEUTICS INC | -- | $274,688.70 | 3,707 | B17VCN9 |
| 0.32% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $265,184.76 | 2,902 | BDCBCD8 |
| 0.32% | PCVX | VAXCYTE INC | -- | $263,462.42 | 6,058 | BKPVGH6 |
| 0.31% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $257,133.14 | 983 | BQ721R4 |
| 0.31% | COGT | COGENT BIOSCIENCES INC | -- | $255,349.23 | 6,519 | BLR6XK8 |
| 0.29% | CRSP | CRISPR THERAPEUTICS AG | -- | $243,951.24 | 4,236 | BDHF4K6 |
| 0.27% | ADMA | ADMA BIOLOGICS INC | -- | $222,477.30 | 11,135 | B9NSBM2 |
| 0.26% | ALKS | ALKERMES PLC | -- | $220,459.86 | 7,703 | B3P6D26 |
| 0.25% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $211,175.64 | 4,394 | BDD19F8 |
| 0.25% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $211,075.13 | 7,873 | 2713317 |
| 0.25% | INDV | INDIVIOR PLC | -- | $206,425.35 | 5,823 | BP0BQQ5 |
| 0.24% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $202,139.35 | 4,487 | BFZQ0L8 |
| 0.23% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $191,722.14 | 2,781 | BQS9486 |
| 0.23% | IMVT | IMMUNOVANT INC | -- | $191,613.48 | 8,133 | BJRFSB7 |
| 0.22% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $187,094.94 | 5,254 | BP8JSP4 |
| 0.22% | ACLX | ARCELLX INC | -- | $186,284.24 | 2,588 | BPCJ1Q2 |
| 0.22% | TERN | TERNS PHARMACEUTICALS INC | -- | $181,874.97 | 4,077 | BMDJ0C9 |
| 0.21% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $178,937.55 | 14,655 | BFNF1D6 |
| 0.20% | LGND | LIGAND PHARMACEUTICALS | -- | $168,387.45 | 915 | 2501578 |
| 0.20% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $166,473.84 | 5,592 | BKX9VD3 |
| 0.20% | APGE | APOGEE THERAPEUTICS INC | -- | $163,757.18 | 2,153 | BM9HHL5 |
| 0.19% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $161,928.00 | 4,498 | BJ62Z18 |
| 0.19% | TARS | TARSUS PHARMACEUTICALS INC | -- | $160,119.08 | 1,969 | BMH5RL1 |
| 0.19% | GRAL | GRAIL INC | -- | $159,758.78 | 1,683 | BSLSSX7 |
| 0.19% | VCYT | VERACYTE INC | -- | $159,064.43 | 3,671 | BFTWZY0 |
| 0.19% | XENE | XENON PHARMACEUTICALS INC | -- | $156,297.12 | 3,598 | BRJ3GY4 |
| 0.18% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $151,586.48 | 2,344 | BJDX8Y8 |
| 0.18% | IRON | DISC MEDICINE INC | -- | $150,509.85 | 1,621 | BMGJZJ8 |
| 0.18% | WVE | WAVE LIFE SCIENCES LTD | -- | $150,227.98 | 7,426 | BYZG9R0 |
| 0.18% | CGON | CG ONCOLOGY INC | -- | $148,510.92 | 3,558 | BRBCSP4 |
| 0.17% | APLS | APELLIS PHARMACEUTICALS INC | -- | $145,463.92 | 5,894 | BYTQ6X1 |
| 0.17% | TVTX | TRAVERE THERAPEUTICS INC | -- | $142,952.04 | 4,158 | BLFGJD5 |
| 0.17% | FOLD | AMICUS THERAPEUTICS INC | -- | $141,682.40 | 14,384 | B19FQ48 |
| 0.16% | IDYA | IDEAYA BIOSCIENCES INC | -- | $137,520.32 | 4,088 | BK0VHF6 |
| 0.16% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $132,296.18 | 4,474 | BLB0YQ9 |
| 0.16% | VERA | VERA THERAPEUTICS INC | -- | $132,000.18 | 2,977 | BL55460 |
| 0.16% | DYN | DYNE THERAPEUTICS INC | -- | $130,682.53 | 6,637 | BN15WD1 |
| 0.16% | BEAM | BEAM THERAPEUTICS INC | -- | $129,382.80 | 4,722 | BK6L288 |
| 0.15% | OCUL | OCULAR THERAPEUTIX INC | -- | $125,098.38 | 8,118 | BNZB1X8 |
| 0.14% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $120,800.72 | 2,617 | B72ZBG4 |
| 0.14% | DNLI | DENALI THERAPEUTICS INC | -- | $119,897.68 | 6,824 | BD2B4V0 |
| 0.14% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $116,705.84 | 4,916 | BKY5JZ8 |
| 0.13% | MLYS | MINERALYS THERAPEUTICS INC | -- | $112,002.80 | 3,094 | BP9N0G0 |
| 0.13% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $111,832.70 | 7,105 | BJ5FZ74 |
| 0.13% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $105,361.41 | 2,683 | BKSGZN7 |
| 0.12% | IBRX | IMMUNITYBIO INC | -- | $101,446.10 | 44,107 | BNSP0B8 |
| 0.12% | SRPT | SAREPTA THERAPEUTICS INC | -- | $101,254.20 | 4,561 | B8DPDT7 |
| 0.12% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $98,237.36 | 3,202 | BMZ4LN0 |
| 0.12% | SYRE | SPYRE THERAPEUTICS INC | -- | $97,706.54 | 2,819 | BQBBDY8 |
| 0.12% | AVDL | AVADEL PHARMACEUTICALS | -- | $97,304.40 | 4,530 | BDGMC59 |
| 0.11% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $95,113.80 | 19,940 | BM9FJ13 |
| 0.11% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $95,016.74 | 6,142 | BFWLC09 |
| 0.11% | TXG | 10X GENOMICS INC-CLASS A | -- | $93,592.67 | 5,339 | BKS3RS7 |
| 0.11% | TWST | TWIST BIOSCIENCE CORP | -- | $92,341.26 | 2,817 | BGKG6G7 |
| 0.11% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $91,758.08 | 3,928 | BMX9K07 |
| 0.11% | ZYME | ZYMEWORKS INC | -- | $90,726.09 | 3,507 | BPCQZY9 |
| 0.11% | VCEL | VERICEL CORP | -- | $88,604.56 | 2,354 | BSBMN89 |
| 0.10% | STOK | STOKE THERAPEUTICS INC | -- | $87,321.55 | 2,557 | BJQ05Z6 |
| 0.10% | HROW | HARROW INC | -- | $86,645.20 | 1,726 | BHNDW86 |
| 0.10% | MNKD | MANNKIND CORP | -- | $83,617.12 | 14,318 | BF081J4 |
| 0.10% | ANIP | ANI PHARMACEUTICALS INC | -- | $83,014.36 | 1,012 | BCDWBX6 |
| 0.10% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $82,892.40 | 4,020 | BN7Q7R7 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $82,225.26 | 2,028 | BRXB0C0 |
| 0.10% | ALVO | ALVOTECH SA | -- | $81,866.12 | 14,804 | BPNTJ34 |
| 0.10% | TRVI | TREVI THERAPEUTICS INC | -- | $80,513.94 | 5,682 | BJH9ZN0 |
| 0.09% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $76,076.00 | 2,717 | BCBVTX1 |
| 0.09% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $75,037.36 | 9,796 | 2100362 |
| 0.09% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $71,824.20 | 1,470 | BX7RSN3 |
| 0.08% | TSHA | TAYSHA GENE THERAPIES INC | -- | $70,767.68 | 12,728 | BNC1BX1 |
| 0.08% | NRIX | NURIX THERAPEUTICS INC | -- | $69,909.65 | 3,565 | BMVLGP2 |
| 0.08% | NVCR | NOVOCURE LTD | -- | $68,968.74 | 5,217 | BYSS4X4 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $67,304.04 | 1,868 | BLCD809 |
| 0.08% | ARDX | ARDELYX INC | -- | $66,570.40 | 11,245 | BN89V40 |
| 0.08% | FTRE | FORTREA HOLDINGS INC | -- | $64,133.04 | 4,236 | BRXYZ57 |
| 0.07% | GMAB | GENMAB A/S -SP ADR | -- | $61,105.44 | 1,956 | BBC9WC7 |
| 0.07% | RLAY | RELAY THERAPEUTICS INC | -- | $61,053.96 | 8,044 | BN2R582 |
| 0.07% | INVA | INNOVIVA INC | -- | $60,643.42 | 2,941 | BDDXF67 |
| 0.07% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $59,633.90 | 5,471 | BRJZSK0 |
| 0.07% | SANA | SANA BIOTECHNOLOGY INC | -- | $59,630.74 | 12,071 | BMFJJ97 |
| 0.07% | ANAB | ANAPTYSBIO INC | -- | $58,749.65 | 1,307 | BDRW1L7 |
| 0.07% | INBX | INHIBRX BIOSCIENCES INC | -- | $57,213.27 | 677 | BNSP8K3 |
| 0.07% | XNCR | XENCOR INC | -- | $57,125.64 | 3,329 | BGCYWN8 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $55,764.99 | 2,169 | BNFWZS4 |
| 0.07% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $55,729.71 | 2,763 | BMFD115 |
| 0.07% | TYRA | TYRA BIOSCIENCES INC | -- | $55,435.23 | 2,487 | BMVNDH9 |
| 0.07% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $54,997.11 | 4,157 | BPCK358 |
| 0.07% | ORKA | ORUKA THERAPEUTICS INC | -- | $54,855.80 | 1,747 | BKVF0J2 |
| 0.07% | ALMS | ALUMIS INC | -- | $54,737.20 | 4,520 | BPLQG36 |
| 0.06% | SVRA | SAVARA INC | -- | $53,961.54 | 8,066 | BYXGN81 |
| 0.06% | EYPT | EYEPOINT PHARMACEUTICALS INC | -- | $53,771.52 | 3,216 | BMGS7L1 |
| 0.06% | PCRX | PACIRA BIOSCIENCES INC | -- | $52,777.28 | 2,096 | B3X26D8 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $52,568.88 | 13,944 | BL53SR3 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $52,292.90 | 7,535 | BLR7H87 |
| 0.06% | QURE | UNIQURE NV | -- | $51,558.40 | 2,560 | BJFSR88 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $51,441.06 | 1,353 | BKLCWZ3 |
| 0.06% | NVAX | NOVAVAX INC | -- | $51,082.46 | 7,579 | BJDQXG4 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $50,943.40 | 5,692 | B8K7T65 |
| 0.06% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $49,656.86 | 2,882 | BP7KZP7 |
| 0.06% | RAPP | RAPPORT THERAPEUTICS INC | -- | $48,853.68 | 1,704 | BR3T9B6 |
| 0.06% | PGEN | PRECIGEN INC | -- | $48,799.53 | 13,903 | BKM5C84 |
| 0.06% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $48,160.50 | 3,310 | BJLKVS6 |
| 0.06% | SPRY | ARS PHARMACEUTICALS INC | -- | $48,138.84 | 4,611 | BMCR7V2 |
| 0.06% | URGN | UROGEN PHARMA LTD | -- | $47,930.40 | 2,160 | BZ7PJQ1 |
| 0.06% | TNGX | TANGO THERAPEUTICS INC | -- | $47,610.64 | 5,192 | BP2P6L0 |
| 0.06% | NTLA | INTELLIA THERAPEUTICS INC | -- | $46,934.33 | 5,009 | BYZM6C2 |
| 0.06% | AVBP | ARRIVENT BIOPHARMA INC | -- | $46,070.20 | 1,892 | BMGTLY5 |
| 0.05% | ORIC | ORIC PHARMACEUTICALS INC | -- | $45,310.00 | 4,531 | BKVDFF7 |
| 0.05% | ARVN | ARVINAS INC | -- | $44,469.48 | 3,426 | BDZ30Q0 |
| 0.05% | MNMD | MIND MEDICINE MINDMED INC | -- | $44,048.04 | 3,558 | BPQYY97 |
| 0.05% | JANX | JANUX THERAPEUTICS INC | -- | $43,686.32 | 2,804 | BMFX8Y7 |
| 0.05% | KURA | KURA ONCOLOGY INC | -- | $43,497.00 | 4,050 | BYZD465 |
| 0.05% | ERAS | ERASCA INC | -- | $43,149.36 | 13,236 | BNLYBF3 |
| 0.05% | VIR | VIR BIOTECHNOLOGY INC | -- | $42,457.10 | 6,482 | BK4PZ38 |
| 0.05% | MESO | MESOBLAST LTD- SPON ADR | -- | $41,967.15 | 2,203 | BQS7491 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $41,383.50 | 2,350 | BMNDK09 |
| 0.05% | KROS | KEROS THERAPEUTICS INC | -- | $41,364.96 | 1,894 | BM7V485 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $41,057.55 | 8,945 | BZ0QMB7 |
| 0.05% | ZLAB | ZAI LAB LTD-ADR | -- | $40,800.96 | 2,232 | BD9GVY0 |
| 0.05% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $40,669.29 | 4,779 | BLB0YH0 |
| 0.05% | CRMD | CORMEDIX INC | -- | $39,950.01 | 3,483 | BJ0LT31 |
| 0.05% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $39,604.14 | 2,349 | BD06CS0 |
| 0.05% | PSNL | PERSONALIS INC | -- | $38,359.26 | 4,138 | BJQ0608 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $38,162.36 | 16,886 | BF0DMK7 |
| 0.05% | GERN | GERON CORP | -- | $38,106.88 | 29,771 | 2370381 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $37,876.50 | 950 | BL95N25 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $36,036.47 | 9,409 | BBNBTD2 |
| 0.04% | REPL | REPLIMUNE GROUP INC | -- | $35,764.44 | 3,642 | BDDVW37 |
| 0.04% | OMER | OMEROS CORP | -- | $35,698.24 | 3,176 | B4NB858 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $35,332.80 | 8,160 | BPBJFM7 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $35,162.12 | 5,644 | BYVQJ96 |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $34,542.36 | 838 | BQD3J33 |
| 0.04% | CGEM | CULLINAN THERAPEUTICS INC | -- | $34,327.30 | 2,755 | BM90J52 |
| 0.04% | ATXS | ASTRIA THERAPEUTICS INC | -- | $34,162.98 | 2,634 | BMYRFN8 |
| 0.04% | LENZ | LENZ THERAPEUTICS INC | -- | $33,328.24 | 1,331 | BQV0J03 |
| 0.04% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $33,217.92 | 14,016 | B4N8MH9 |
| 0.04% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $31,496.06 | 3,754 | BFYQFJ2 |
| 0.04% | RGNX | REGENXBIO INC | -- | $30,899.96 | 2,366 | BZ0G875 |
| 0.04% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $29,528.22 | 3,478 | BYP80F1 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $28,633.20 | 4,280 | BMC3HS7 |
| 0.03% | LYEL | LYELL IMMUNOPHARMA INC | -- | $28,089.44 | 898 | BTNMG41 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $27,966.51 | 7,579 | B3MZ6K5 |
| 0.03% | ABSI | ABSCI CORP | -- | $27,702.66 | 6,978 | BN94K69 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $25,184.96 | 6,752 | BMCWKZ2 |
| 0.03% | ANNX | ANNEXON INC | -- | $25,097.80 | 5,122 | BMVV9R5 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $25,028.94 | 2,657 | BMFK3H6 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $24,793.44 | 2,512 | B91XRN2 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $24,519.60 | 2,520 | BQ6C357 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $23,598.57 | 2,179 | BKLXFX5 |
| 0.03% | LXRX | LEXICON PHARMACEUTICALS INC | -- | $22,384.56 | 16,958 | BWFZX59 |
| 0.03% | ALT | ALTIMMUNE INC | -- | $22,366.17 | 4,119 | BFY7DC4 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $22,139.00 | 2,620 | BLFBZ32 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $21,628.77 | 669 | B292NQ7 |
| 0.03% | EOLS | EVOLUS INC | -- | $21,374.52 | 3,019 | BDRJH21 |
| 0.03% | SLDB | SOLID BIOSCIENCES INC | -- | $21,367.92 | 3,634 | BQHN6C7 |
| 0.03% | SIGA | SIGA TECHNOLOGIES INC | -- | $20,881.25 | 3,341 | 2107437 |
| 0.02% | HCM | HUTCHMED CHINA-ADR | -- | $19,953.44 | 1,448 | BYXV9H7 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $18,807.84 | 1,776 | BP81RK8 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $18,750.06 | 2,898 | BP81R42 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $18,603.00 | 2,756 | B12W3P6 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $18,277.05 | 5,035 | BDFKQ07 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $17,595.32 | 873 | BPBPCG8 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $16,507.24 | 2,018 | BSMLR16 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $16,348.56 | 4,007 | BYTYP72 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $16,205.60 | 2,155 | BKDQKM6 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $15,794.13 | 7,557 | BN4JN37 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $15,736.36 | 3,994 | BMXNGZ6 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $15,323.92 | 10,354 | BFZNYB7 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $14,341.26 | 998 | B9L5200 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $14,317.74 | 9,358 | BFMLGR4 |
| 0.02% | NGNE | NEUROGENE INC | -- | $13,846.92 | 667 | BS2F741 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $13,803.30 | 2,205 | BL5B6Z1 |
| 0.02% | AMRN | AMARIN CORP PLC -ADR | -- | $13,395.00 | 940 | BN72KB0 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $12,987.45 | 4,655 | BZC0D70 |
| 0.01% | PYXS | PYXIS ONCOLOGY INC | -- | $12,415.26 | 2,894 | BLBR8D5 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $12,010.57 | 2,497 | BP7L561 |
| 0.01% | FHTX | FOGHORN THERAPEUTICS INC | -- | $11,739.10 | 2,638 | BMF7DT9 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $11,701.48 | 3,703 | BLN9Z50 |
| 0.01% | OABI | OMNIAB INC | -- | $11,450.00 | 5,725 | BN13S71 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $11,438.96 | 2,588 | BY7RB53 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $10,909.60 | 4,196 | BZ8FPH3 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $9,717.89 | 1,267 | BKC9SX3 |
| 0.01% | RNAC | CARTESIAN THERAPEUTICS INC | -- | $9,529.90 | 1,214 | BQB9HM8 |
| 0.01% | HUMA | HUMACYTE INC | -- | $9,385.30 | 7,390 | BMYTJP4 |
| 0.01% | PEPG | PEPGEN INC | -- | $8,956.35 | 1,531 | BMTX3D7 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $8,570.76 | 3,322 | BKX9NQ0 |
| 0.01% | CDXS | CODEXIS INC | -- | $7,665.84 | 4,212 | B5LL2C2 |
| 0.01% | MXCT | MAXCYTE INC | -- | $7,661.50 | 4,975 | BKMQF66 |
| 0.01% | CLYM | CLIMB BIO INC | -- | $6,579.04 | 3,163 | BMW5LX6 |
| 0.01% | MRSN | MERSANA THERAPEUTICS INC | -- | $6,549.63 | 233 | BVPKH99 |
| 0.01% | NKTX | NKARTA INC | -- | $6,232.20 | 3,315 | BK80YJ8 |
| 0.01% | ALEC | ALECTOR INC | -- | $6,141.20 | 4,724 | BJ4LDC4 |
| 0.01% | FATE | FATE THERAPEUTICS INC | -- | $5,866.38 | 5,382 | BCZS820 |
| 0.01% | BMEA | BIOMEA FUSION INC | -- | $4,276.58 | 2,777 | BNKF6N0 |
| -- | MGNX | MACROGENICS INC | -- | $4,130.00 | 2,950 | BFDV8K0 |
| -- | TVGN | TEVOGEN BIO HOLDINGS INC | -- | $4,018.57 | 9,179 | BPG5P75 |
| -- | ACRV | ACRIVON THERAPEUTICS INC | -- | $3,846.16 | 1,468 | BP2TPK4 |
| -- | PLRX | PLIANT THERAPEUTICS INC | -- | $3,667.20 | 2,865 | BMDWW66 |
| -- | -- | SUTRO BIOPHARMA INC COMMON STOCK USD 0.001 | -- | $3,555.00 | 395 | -- |
| -- | ARTV | ARTIVA BIOTHERAPEUTICS INC | -- | $3,499.80 | 1,140 | BMF1LJ7 |
| -- | TCRX | TSCAN THERAPEUTICS INC | -- | $2,521.44 | 2,448 | BNLYBJ7 |
| -- | OKUR | ONKURE THERAPEUTICS INC-A | -- | $2,082.00 | 600 | BT7KGT6 |
| -- | QTTB | Q32 BIO INC | -- | $1,897.12 | 568 | BS2FKQ4 |
| -- | APLT | APPLIED THERAPEUTICS INC | -- | $1,478.18 | 6,719 | BJL38Z1 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 34.11% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 28,452,902 | -- | 5,008 | -- |
| 33.91% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 28,288,139 | -- | 4,979 | -- |
| 26.54% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 22,140,767 | -- | 3,897 | -- |
| 16.92% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,112,821 | -- | 2,484 | -- |
| 15.66% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 13,061,746 | -- | 2,299 | -- |
| 4.31% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,596,383 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $25,785,239.14 | 25,785,239 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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