BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 2/28/2026
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 6.03% | 5.70% | 60.37% | 10.56% | 62.26% | 19.25% | -0.31% | 8.72% | 16.98% | 04/07/2010 |
| BIB Market Price | 6.05% | 5.51% | 60.28% | 10.49% | 62.05% | 19.26% | -0.28% | 8.72% | 16.98% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 3/04/2026- NAV $85.92
- NAV Change $+2.62
- Market Price $85.99
- Market Price Change $+2.67
- Trading Volume (M) 7,925
- 30-Day Median Bid Ask Spread 0.26%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 3/04/2026- NAV $85.92
- NAV Change $+2.62
- Market Price $85.99
- Market Price Change $+2.67
- Trading Volume (M) 7,925
- 30-Day Median Bid Ask Spread 0.26%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 12/31/2025
Holdings
as of 3/04/2026
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 6.62% | GILD | GILEAD SCIENCES INC | -- | $5,914,570.88 | 39,904 | 2369174 |
| 6.19% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,534,444.09 | 11,581 | 2931034 |
| 6.17% | AMGN | AMGEN INC | -- | $5,513,068.72 | 14,536 | 2023607 |
| 4.20% | REGN | REGENERON PHARMACEUTICALS | -- | $3,755,587.50 | 4,769 | 2730190 |
| 2.23% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $1,996,857.30 | 6,101 | B00FWN1 |
| 1.65% | INSM | INSMED INC | -- | $1,476,018.24 | 9,848 | 2614487 |
| 1.44% | BIIB | BIOGEN INC | -- | $1,286,653.56 | 6,774 | 2455965 |
| 1.17% | MRNA | MODERNA INC | -- | $1,042,654.20 | 18,039 | BGSXTS3 |
| 1.13% | ARGX | ARGENX SE - ADR | -- | $1,007,408.64 | 1,344 | BDVLM39 |
| 1.09% | UTHR | UNITED THERAPEUTICS CORP | -- | $974,537.48 | 1,988 | 2430412 |
| 1.06% | ROIV | ROIVANT SCIENCES LTD | -- | $948,005.28 | 32,114 | BMW4NZ9 |
| 1.05% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $935,746.47 | 19,729 | BMVP7Y0 |
| 1.02% | ILMN | ILLUMINA INC | -- | $909,883.35 | 7,055 | 2613990 |
| 1.01% | RVMD | REVOLUTION MEDICINES INC | -- | $903,323.13 | 8,927 | BL71K91 |
| 1.00% | INCY | INCYTE CORP | -- | $896,165.90 | 9,065 | 2471950 |
| 0.88% | VTRS | VIATRIS INC | -- | $782,321.93 | 53,183 | BMWS3X9 |
| 0.77% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $684,312.30 | 2,835 | BV9G6B8 |
| 0.69% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $614,357.76 | 4,604 | 2623911 |
| 0.68% | MEDP | MEDPACE HOLDINGS INC | -- | $606,083.86 | 1,301 | BDCBC61 |
| 0.66% | IONS | IONIS PHARMACEUTICALS INC | -- | $594,206.55 | 7,479 | BDJ0LS6 |
| 0.66% | BBIO | BRIDGEBIO PHARMA INC | -- | $592,006.38 | 8,897 | BK1KWG8 |
| 0.63% | SNY | SANOFI-ADR | -- | $564,762.18 | 12,219 | 2964557 |
| 0.62% | GH | GUARDANT HEALTH INC | -- | $555,701.48 | 5,974 | BFXC911 |
| 0.60% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $536,074.53 | 8,871 | 2437071 |
| 0.59% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $529,464.14 | 2,806 | B4Q5ZN4 |
| 0.59% | SMMT | SUMMIT THERAPEUTICS INC | -- | $528,687.50 | 34,375 | BMTVQS7 |
| 0.58% | EXEL | EXELIXIS INC | -- | $516,163.89 | 12,381 | 2576941 |
| 0.54% | BNTX | BIONTECH SE-ADR | -- | $484,642.20 | 4,669 | BK6H543 |
| 0.51% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $455,670.40 | 1,048 | BD59BS7 |
| 0.49% | ONC | BEONE MEDICINES LTD-ADR | -- | $434,775.08 | 1,454 | BYYWPW6 |
| 0.46% | TEM | TEMPUS AI INC-CL A | -- | $409,396.78 | 7,982 | BSLSJJ0 |
| 0.46% | IBRX | IMMUNITYBIO INC | -- | $409,329.00 | 45,481 | BNSP0B8 |
| 0.46% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $408,242.10 | 6,271 | BYQBFJ8 |
| 0.43% | AXSM | AXSOME THERAPEUTICS INC | -- | $381,814.16 | 2,327 | BYZR4X4 |
| 0.43% | HALO | HALOZYME THERAPEUTICS INC | -- | $380,208.60 | 5,430 | 2975098 |
| 0.42% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $375,502.05 | 1,155 | BQ721R4 |
| 0.41% | PCVX | VAXCYTE INC | -- | $363,425.72 | 6,044 | BKPVGH6 |
| 0.40% | KRYS | KRYSTAL BIOTECH INC | -- | $354,835.00 | 1,339 | BD6JX35 |
| 0.39% | CYTK | CYTOKINETICS INC | -- | $351,576.42 | 5,646 | BBBSBJ5 |
| 0.38% | NUVL | NUVALENT INC-A | -- | $342,404.45 | 3,335 | BMVBZD3 |
| 0.36% | ABVX | ABIVAX SA-ADR | -- | $318,315.02 | 2,726 | BLC89B2 |
| 0.34% | ACLX | ARCELLX INC | -- | $305,181.00 | 2,670 | BPCJ1Q2 |
| 0.32% | KYMR | KYMERA THERAPEUTICS INC | -- | $286,057.42 | 3,322 | BMPRZV5 |
| 0.31% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $280,462.00 | 3,082 | BF2YWG4 |
| 0.31% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $273,774.21 | 2,887 | BDCBCD8 |
| 0.30% | CRSP | CRISPR THERAPEUTICS AG | -- | $264,000.00 | 4,400 | BDHF4K6 |
| 0.29% | COGT | COGENT BIOSCIENCES INC | -- | $262,397.76 | 7,088 | BLR6XK8 |
| 0.29% | CAI | CARIS LIFE SCIENCES INC | -- | $258,755.94 | 13,029 | BT18HP9 |
| 0.27% | PTCT | PTC THERAPEUTICS INC | -- | $238,323.03 | 3,707 | B17VCN9 |
| 0.26% | CGON | CG ONCOLOGY INC | -- | $229,348.25 | 3,725 | BRBCSP4 |
| 0.25% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $223,395.30 | 4,710 | BFZQ0L8 |
| 0.25% | ALKS | ALKERMES PLC | -- | $223,230.72 | 7,624 | B3P6D26 |
| 0.25% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $220,783.92 | 2,373 | BJDX8Y8 |
| 0.25% | IMVT | IMMUNOVANT INC | -- | $219,185.52 | 8,094 | BJRFSB7 |
| 0.23% | FOLD | AMICUS THERAPEUTICS INC | -- | $204,159.51 | 14,247 | B19FQ48 |
| 0.22% | ERAS | ERASCA INC | -- | $198,087.12 | 13,101 | BNLYBF3 |
| 0.22% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $194,819.18 | 3,086 | BQS9486 |
| 0.22% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $193,062.80 | 14,516 | BFNF1D6 |
| 0.21% | LGND | LIGAND PHARMACEUTICALS | -- | $189,935.55 | 909 | 2501578 |
| 0.21% | INDV | INDIVIOR PHARMACEUTICALS INC | -- | $185,338.08 | 5,763 | BTZRLN8 |
| 0.20% | APGE | APOGEE THERAPEUTICS INC | -- | $183,088.92 | 2,532 | BM9HHL5 |
| 0.20% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $182,722.68 | 7,812 | 2713317 |
| 0.20% | ADMA | ADMA BIOLOGICS INC | -- | $181,774.60 | 10,990 | B9NSBM2 |
| 0.20% | TERN | TERNS PHARMACEUTICALS INC | -- | $176,924.80 | 4,160 | BMDJ0C9 |
| 0.19% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $173,132.82 | 4,382 | BDD19F8 |
| 0.18% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $163,258.48 | 5,236 | BP8JSP4 |
| 0.17% | XENE | XENON PHARMACEUTICALS INC | -- | $153,602.40 | 3,568 | BRJ3GY4 |
| 0.17% | TARS | TARSUS PHARMACEUTICALS INC | -- | $149,428.20 | 1,961 | BMH5RL1 |
| 0.16% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $147,175.84 | 2,648 | B72ZBG4 |
| 0.16% | SYRE | SPYRE THERAPEUTICS INC | -- | $146,903.00 | 3,583 | BQBBDY8 |
| 0.16% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $141,194.32 | 4,889 | BKY5JZ8 |
| 0.16% | IDYA | IDEAYA BIOSCIENCES INC | -- | $140,384.64 | 4,048 | BK0VHF6 |
| 0.15% | DNLI | DENALI THERAPEUTICS INC | -- | $137,945.64 | 6,772 | BD2B4V0 |
| 0.15% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $136,422.72 | 5,656 | BKX9VD3 |
| 0.15% | TWST | TWIST BIOSCIENCE CORP | -- | $135,673.38 | 2,823 | BGKG6G7 |
| 0.15% | VCYT | VERACYTE INC | -- | $132,385.50 | 3,650 | BFTWZY0 |
| 0.15% | ALMS | ALUMIS INC | -- | $129,597.43 | 4,489 | BPLQG36 |
| 0.14% | BEAM | BEAM THERAPEUTICS INC | -- | $128,556.40 | 4,685 | BK6L288 |
| 0.13% | TXG | 10X GENOMICS INC-CLASS A | -- | $120,328.23 | 5,379 | BKS3RS7 |
| 0.13% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $118,948.50 | 4,455 | BLB0YQ9 |
| 0.13% | VERA | VERA THERAPEUTICS INC | -- | $116,967.50 | 2,950 | BL55460 |
| 0.13% | TVTX | TRAVERE THERAPEUTICS INC | -- | $116,411.58 | 4,131 | BLFGJD5 |
| 0.13% | APLS | APELLIS PHARMACEUTICALS INC | -- | $115,962.54 | 5,839 | BYTQ6X1 |
| 0.13% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $115,885.56 | 7,049 | BJ5FZ74 |
| 0.12% | OCUL | OCULAR THERAPEUTIX INC | -- | $108,600.48 | 9,837 | BNZB1X8 |
| 0.12% | IRON | DISC MEDICINE INC | -- | $106,558.40 | 1,744 | BMGJZJ8 |
| 0.12% | WVE | WAVE LIFE SCIENCES LTD | -- | $105,882.33 | 7,723 | BYZG9R0 |
| 0.12% | MLYS | MINERALYS THERAPEUTICS INC | -- | $105,125.58 | 3,654 | BP9N0G0 |
| 0.12% | MAZE | MAZE THERAPEUTICS INC | -- | $103,278.56 | 2,222 | BSRK699 |
| 0.11% | DYN | DYNE THERAPEUTICS INC | -- | $100,441.85 | 6,595 | BN15WD1 |
| 0.11% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $98,605.22 | 2,086 | BRXB0C0 |
| 0.11% | GRAL | GRAIL INC | -- | $97,272.00 | 1,800 | BSLSSX7 |
| 0.11% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $97,119.00 | 4,455 | BJ62Z18 |
| 0.10% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $91,563.52 | 6,088 | BFWLC09 |
| 0.10% | STOK | STOKE THERAPEUTICS INC | -- | $90,799.96 | 2,638 | BJQ05Z6 |
| 0.10% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $88,402.88 | 3,632 | BMZ4LN0 |
| 0.10% | ZYME | ZYMEWORKS INC | -- | $87,194.88 | 3,456 | BPCQZY9 |
| 0.10% | TYRA | TYRA BIOSCIENCES INC | -- | $86,905.28 | 2,464 | BMVNDH9 |
| 0.10% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $86,782.68 | 4,014 | BN7Q7R7 |
| 0.10% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $86,424.52 | 23,743 | BM9FJ13 |
| 0.09% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $83,317.54 | 9,722 | 2100362 |
| 0.09% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $82,175.18 | 2,741 | BMFD115 |
| 0.09% | VCEL | VERICEL CORP | -- | $81,631.60 | 2,335 | BSBMN89 |
| 0.09% | RLAY | RELAY THERAPEUTICS INC | -- | $81,230.45 | 8,003 | BN2R582 |
| 0.09% | DFTX | DEFINIUM THERAPEUTICS INC | -- | $80,772.48 | 4,548 | BV2DHY6 |
| 0.09% | ANIP | ANI PHARMACEUTICALS INC | -- | $79,361.61 | 1,037 | BCDWBX6 |
| 0.09% | PHVS | PHARVARIS NV | -- | $79,274.40 | 2,958 | BMZ2X38 |
| 0.09% | INVA | INNOVIVA INC | -- | $78,486.69 | 3,453 | BDDXF67 |
| 0.09% | ORKA | ORUKA THERAPEUTICS INC | -- | $78,237.64 | 2,236 | BKVF0J2 |
| 0.09% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $78,085.80 | 18,330 | BF0DMK7 |
| 0.09% | SRPT | SAREPTA THERAPEUTICS INC | -- | $77,843.42 | 4,838 | B8DPDT7 |
| 0.09% | ANAB | ANAPTYSBIO INC | -- | $77,382.90 | 1,278 | BDRW1L7 |
| 0.09% | TNGX | TANGO THERAPEUTICS INC | -- | $76,804.65 | 6,219 | BP2P6L0 |
| 0.09% | TRVI | TREVI THERAPEUTICS INC | -- | $76,499.32 | 5,921 | BJH9ZN0 |
| 0.09% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $76,318.55 | 5,071 | BPCK358 |
| 0.09% | NRIX | NURIX THERAPEUTICS INC | -- | $76,096.80 | 4,680 | BMVLGP2 |
| 0.09% | GMAB | GENMAB A/S -SP ADR | -- | $76,057.82 | 2,699 | BBC9WC7 |
| 0.08% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $75,916.40 | 2,660 | BKSGZN7 |
| 0.08% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $75,887.48 | 2,692 | BCBVTX1 |
| 0.08% | ARDX | ARDELYX INC | -- | $74,613.00 | 11,220 | BN89V40 |
| 0.08% | NVAX | NOVAVAX INC | -- | $74,214.56 | 7,504 | BJDQXG4 |
| 0.08% | NTLA | INTELLIA THERAPEUTICS INC | -- | $73,909.36 | 5,348 | BYZM6C2 |
| 0.08% | SION | SIONNA THERAPEUTICS INC | -- | $71,248.77 | 2,061 | BQKXDX4 |
| 0.08% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $69,400.80 | 3,888 | BMX9K07 |
| 0.08% | NVCR | NOVOCURE LTD | -- | $69,394.82 | 5,171 | BYSS4X4 |
| 0.08% | EYPT | EYEPOINT INC | -- | $68,796.00 | 3,822 | BMGS7L1 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $67,965.95 | 2,015 | BLCD809 |
| 0.08% | HROW | HARROW INC | -- | $67,066.20 | 1,710 | BHNDW86 |
| 0.07% | KOD | KODIAK SCIENCES INC | -- | $65,758.00 | 2,450 | BFXC933 |
| 0.07% | MBX | MBX BIOSCIENCES INC | -- | $64,905.63 | 2,073 | BQXJKH2 |
| 0.07% | RAPP | RAPPORT THERAPEUTICS INC | -- | $64,577.34 | 2,201 | BR3T9B6 |
| 0.07% | ZBIO | ZENAS BIOPHARMA INC | -- | $63,981.96 | 2,478 | BQB42H3 |
| 0.07% | ATAI | ATAIBECKLEY INC | -- | $61,881.30 | 16,770 | BWJDYK1 |
| 0.07% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $61,530.16 | 3,449 | BYP80F1 |
| 0.07% | VIR | VIR BIOTECHNOLOGY INC | -- | $61,413.44 | 6,424 | BK4PZ38 |
| 0.07% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $61,016.67 | 4,741 | BLB0YH0 |
| 0.07% | ORIC | ORIC PHARMACEUTICALS INC | -- | $60,754.47 | 4,497 | BKVDFF7 |
| 0.07% | SEPN | SEPTERNA INC | -- | $59,581.28 | 2,067 | BQNKXX2 |
| 0.07% | TSHA | TAYSHA GENE THERAPIES INC | -- | $58,686.72 | 12,648 | BNC1BX1 |
| 0.06% | PGEN | PRECIGEN INC | -- | $57,999.90 | 16,338 | BKM5C84 |
| 0.06% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $57,830.60 | 1,460 | BX7RSN3 |
| 0.06% | ALVO | ALVOTECH SA | -- | $56,226.06 | 14,454 | BPNTJ34 |
| 0.06% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $55,960.27 | 3,007 | BP7KZP7 |
| 0.06% | SVRA | SAVARA INC | -- | $52,799.90 | 9,395 | BYXGN81 |
| 0.06% | AVBP | ARRIVENT BIOPHARMA INC | -- | $50,623.36 | 1,906 | BMGTLY5 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $50,173.86 | 13,822 | BL53SR3 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $50,151.36 | 672 | BNSP8K3 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $49,087.94 | 946 | BL95N25 |
| 0.05% | GRFS | GRIFOLS SA-ADR | -- | $48,781.78 | 5,633 | B8K7T65 |
| 0.05% | SANA | SANA BIOTECHNOLOGY INC | -- | $46,986.00 | 12,300 | BMFJJ97 |
| 0.05% | BCAX | BICARA THERAPEUTICS INC | -- | $46,906.20 | 2,530 | BQB42F1 |
| 0.05% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $46,508.34 | 7,662 | BLR7H87 |
| 0.05% | GHRS | GH RESEARCH PLC | -- | $45,795.36 | 2,864 | BP6C0S2 |
| 0.05% | PCRX | PACIRA BIOSCIENCES INC | -- | $45,399.96 | 1,986 | B3X26D8 |
| 0.05% | CGEM | CULLINAN THERAPEUTICS INC | -- | $44,466.40 | 2,728 | BM90J52 |
| 0.05% | FTRE | FORTREA HOLDINGS INC | -- | $44,281.08 | 4,266 | BRXYZ57 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $43,585.92 | 2,162 | BZ7PJQ1 |
| 0.05% | GERN | GERON CORP | -- | $43,329.72 | 29,476 | 2370381 |
| 0.05% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $42,355.12 | 2,122 | BNFWZS4 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $42,184.75 | 8,881 | BZ0QMB7 |
| 0.05% | XNCR | XENCOR INC | -- | $42,016.52 | 3,298 | BGCYWN8 |
| 0.05% | MNKD | MANNKIND CORP | -- | $41,831.00 | 14,180 | BF081J4 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $41,258.56 | 4,564 | BMCR7V2 |
| 0.05% | ARVN | ARVINAS INC | -- | $40,798.40 | 2,965 | BDZ30Q0 |
| 0.04% | JANX | JANUX THERAPEUTICS INC | -- | $39,849.95 | 2,777 | BMFX8Y7 |
| 0.04% | CTMX | CYTOMX THERAPEUTICS INC | -- | $39,662.61 | 7,823 | BYWVTY5 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $38,207.58 | 2,334 | BD06CS0 |
| 0.04% | CSTL | CASTLE BIOSCIENCES INC | -- | $37,973.16 | 1,348 | BKLCWZ3 |
| 0.04% | OMER | OMEROS CORP | -- | $37,945.66 | 3,274 | B4NB858 |
| 0.04% | ANNX | ANNEXON INC | -- | $37,357.97 | 6,683 | BMVV9R5 |
| 0.04% | PSNL | PERSONALIS INC | -- | $36,621.93 | 4,101 | BJQ0608 |
| 0.04% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $36,332.10 | 3,285 | BJLKVS6 |
| 0.04% | BIOA | BIOAGE LABS INC | -- | $34,891.92 | 1,656 | BT9K6D8 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $34,840.16 | 1,808 | BD9GVY0 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $34,353.90 | 4,018 | BYZD465 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $34,340.20 | 8,335 | BPBJFM7 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $33,009.12 | 2,264 | BQS7491 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $32,120.58 | 11,038 | BBNBTD2 |
| 0.04% | TBPH | THERAVANCE BIOPHARMA INC | -- | $31,976.10 | 2,340 | BMNDK09 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $30,674.55 | 4,351 | BMC3HS7 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $28,094.88 | 7,512 | B3MZ6K5 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $27,542.97 | 3,717 | BFYQFJ2 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $27,273.10 | 2,630 | BMFK3H6 |
| 0.03% | REPL | REPLIMUNE GROUP INC | -- | $26,259.50 | 3,622 | BDDVW37 |
| 0.03% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $26,253.81 | 10,377 | BFZNYB7 |
| 0.03% | QURE | UNIQURE NV | -- | $26,008.08 | 2,877 | BJFSR88 |
| 0.03% | CRMD | CORMEDIX INC | -- | $25,902.56 | 3,638 | BJ0LT31 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $25,578.72 | 6,696 | BMCWKZ2 |
| 0.03% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $24,829.94 | 838 | BQD3J33 |
| 0.03% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $24,616.21 | 5,633 | BYVQJ96 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $24,502.10 | 2,485 | B91XRN2 |
| 0.03% | KMDA | KAMADA LTD | -- | $24,482.16 | 2,664 | B2Q9833 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $24,398.80 | 3,370 | BQ6C357 |
| 0.03% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $24,051.80 | 4,990 | BDFKQ07 |
| 0.03% | TECX | TECTONIC THERAPEUTIC INC | -- | $23,682.24 | 864 | BPBPCG8 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $23,557.34 | 2,638 | BKLXFX5 |
| 0.03% | NMRA | NEUMORA THERAPEUTICS INC | -- | $23,530.75 | 7,715 | BN4JN37 |
| 0.03% | LYEL | LYELL IMMUNOPHARMA INC | -- | $23,300.20 | 979 | BTNMG41 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $23,218.00 | 2,600 | BLFBZ32 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $22,504.92 | 668 | B292NQ7 |
| 0.03% | VNDA | VANDA PHARMACEUTICALS INC | -- | $22,377.80 | 2,729 | B12W3P6 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $22,091.72 | 3,598 | BQHN6C7 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $22,062.50 | 1,765 | BP81RK8 |
| 0.02% | IVVD | INVIVYD INC | -- | $21,881.16 | 12,796 | BM8NHS1 |
| 0.02% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $21,747.96 | 13,941 | B4N8MH9 |
| 0.02% | ETON | ETON PHARMACEUTICALS INC | -- | $21,719.67 | 1,239 | BGL0JK3 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $21,543.85 | 3,953 | BMXNGZ6 |
| 0.02% | PEPG | PEPGEN INC | -- | $21,463.00 | 3,175 | BMTX3D7 |
| 0.02% | RGNX | REGENXBIO INC | -- | $21,360.18 | 2,337 | BZ0G875 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $21,065.59 | 3,307 | 2107437 |
| 0.02% | FULC | FULCRUM THERAPEUTICS INC | -- | $20,866.65 | 2,499 | BJDX8Z9 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $20,625.00 | 4,125 | BYTYP72 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $20,577.13 | 4,819 | BFY7DC4 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $20,526.12 | 1,332 | B9L5200 |
| 0.02% | UPB | UPSTREAM BIO INC | -- | $19,461.00 | 2,495 | BRCFFK6 |
| 0.02% | KROS | KEROS THERAPEUTICS INC | -- | $19,360.62 | 1,406 | BM7V485 |
| 0.02% | LENZ | LENZ THERAPEUTICS INC | -- | $18,727.20 | 1,445 | BQV0J03 |
| 0.02% | ABSI | ABSCI CORP | -- | $18,471.04 | 6,944 | BN94K69 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $18,031.80 | 2,932 | BP81R42 |
| 0.02% | AVIR | ATEA PHARMACEUTICALS INC | -- | $17,962.86 | 3,607 | BLN9Z50 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $17,944.01 | 2,023 | BSMLR16 |
| 0.02% | NGNE | NEUROGENE INC | -- | $17,095.65 | 715 | BS2F741 |
| 0.02% | EOLS | EVOLUS INC | -- | $16,730.87 | 2,993 | BDRJH21 |
| 0.02% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $15,855.62 | 1,067 | BPRBTY7 |
| 0.02% | ACRS | ACLARIS THERAPEUTICS INC | -- | $15,509.30 | 5,003 | BYV2W40 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $15,411.77 | 2,981 | BMVBZF5 |
| 0.02% | CABA | CABALETTA BIO INC | -- | $15,246.35 | 4,445 | BK5MWR1 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $15,097.06 | 9,262 | BFMLGR4 |
| 0.02% | NBP | NOVABRIDGE BIOSCIENCES | -- | $14,931.11 | 4,801 | BKRRKY7 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $14,886.40 | 2,326 | B7F2TY6 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $14,804.37 | 2,611 | BMF7DT9 |
| 0.02% | CCCC | C4 THERAPEUTICS INC | -- | $13,827.75 | 4,475 | BKX9NQ0 |
| 0.01% | ACIU | AC IMMUNE SA | -- | $13,166.24 | 4,636 | BZC0D70 |
| 0.01% | CADL | CANDEL THERAPEUTICS INC | -- | $12,548.25 | 2,535 | BP0TQC5 |
| 0.01% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $12,536.82 | 2,169 | BL5B6Z1 |
| 0.01% | LFCR | LIFECORE BIOMEDICAL INC | -- | $12,213.80 | 1,730 | 2517058 |
| 0.01% | OABI | OMNIAB INC | -- | $12,031.07 | 6,647 | BN13S71 |
| 0.01% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $12,025.68 | 2,136 | BKDQKM6 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $11,887.92 | 2,607 | BPRB2N7 |
| 0.01% | VOR | VOR BIOPHARMA INC | -- | $11,708.90 | 778 | BRJJYT3 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $11,237.73 | 2,721 | BY7RB53 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $9,944.96 | 1,312 | BKC9SX3 |
| 0.01% | HUMA | HUMACYTE INC | -- | $9,944.05 | 8,647 | BMYTJP4 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $9,872.52 | 4,508 | BZ8FPH3 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $9,822.56 | 5,581 | BRK0149 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $8,248.32 | 1,432 | BP2NYN2 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $8,217.30 | 9,030 | BNR5QT9 |
| 0.01% | MENS | JYONG BIOTECH LTD | -- | $8,005.08 | 3,511 | BPTK6Z2 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $7,768.80 | 4,316 | BNYJR68 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $6,472.26 | 2,631 | BKTV702 |
| 0.01% | GOSS | GOSSAMER BIO INC | -- | $6,198.46 | 10,687 | BJ0CK86 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $6,125.44 | 4,504 | BNNXX18 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $5,769.79 | 2,471 | BP7L561 |
| 0.01% | AARD | AARDVARK THERAPEUTICS INC | -- | $5,668.20 | 1,005 | BTXQTX3 |
| 0.01% | CDXS | CODEXIS INC | -- | $4,504.68 | 4,171 | B5LL2C2 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $4,469.80 | 7,688 | BNNXX52 |
| -- | PYXS | PYXIS ONCOLOGY INC | -- | $4,283.75 | 2,875 | BLBR8D5 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $21.31 | 01 | BTFHQP5 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| 39.53% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 35,320,330 | -- | 5,919 | -- |
| 28.65% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 25,605,598 | -- | 4,291 | -- |
| 25.55% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 22,830,813 | -- | 3,826 | -- |
| 17.62% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 15,747,652 | -- | 2,639 | -- |
| 16.59% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,822,724 | -- | 2,484 | -- |
| 4.23% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,777,288 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $28,361,391.28 | 28,361,391 | -- |
Index
as of 12/31/2025
- Total Number of Companies262
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$7.32 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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