BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 11/30/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 16.90% | 51.72% | 95.62% | 66.67% | 42.59% | 11.36% | 1.61% | 2.01% | 16.86% | 04/07/2010 |
| BIB Market Price | 17.00% | 51.90% | 95.85% | 66.74% | 42.98% | 11.47% | 1.66% | 2.03% | 16.87% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/23/2025- NAV $82.74
- NAV Change $-0.60
- Market Price $82.63
- Market Price Change $-0.60
- Trading Volume (M) 13,177
- 30-Day Median Bid Ask Spread 0.25%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/23/2025- NAV $82.74
- NAV Change $-0.60
- Market Price $82.63
- Market Price Change $-0.60
- Trading Volume (M) 13,177
- 30-Day Median Bid Ask Spread 0.25%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 12/23/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.87% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,088,965.22 | 11,082 | 2931034 |
| 5.51% | GILD | GILEAD SCIENCES INC | -- | $4,778,502.30 | 38,170 | 2369174 |
| 5.31% | AMGN | AMGEN INC | -- | $4,609,699.94 | 13,906 | 2023607 |
| 4.13% | REGN | REGENERON PHARMACEUTICALS | -- | $3,581,945.54 | 4,562 | 2730190 |
| 2.74% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $2,376,106.32 | 25,788 | 2989044 |
| 2.68% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,326,414.50 | 5,835 | B00FWN1 |
| 1.92% | INSM | INSMED INC | -- | $1,665,173.40 | 9,420 | 2614487 |
| 1.31% | BIIB | BIOGEN INC | -- | $1,132,833.60 | 6,480 | 2455965 |
| 1.25% | ARGX | ARGENX SE - ADR | -- | $1,087,891.70 | 1,286 | BDVLM39 |
| 1.12% | UTHR | UNITED THERAPEUTICS CORP | -- | $970,856.88 | 1,902 | 2430412 |
| 1.06% | ILMN | ILLUMINA INC | -- | $919,146.31 | 6,749 | 2613990 |
| 1.01% | INCY | INCYTE CORP | -- | $874,990.61 | 8,671 | 2471950 |
| 0.86% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $743,328.69 | 18,871 | BMVP7Y0 |
| 0.82% | MEDP | MEDPACE HOLDINGS INC | -- | $708,706.80 | 1,244 | BDCBC61 |
| 0.80% | ROIV | ROIVANT SCIENCES LTD | -- | $689,641.55 | 30,719 | BMW4NZ9 |
| 0.79% | RVMD | REVOLUTION MEDICINES INC | -- | $685,425.53 | 8,539 | BL71K91 |
| 0.75% | BBIO | BRIDGEBIO PHARMA INC | -- | $650,316.80 | 8,512 | BK1KWG8 |
| 0.75% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $648,621.12 | 4,404 | 2623911 |
| 0.70% | VTRS | VIATRIS INC | -- | $611,241.04 | 50,852 | BMWS3X9 |
| 0.70% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $604,016.63 | 1,003 | BD59BS7 |
| 0.69% | SMMT | SUMMIT THERAPEUTICS INC | -- | $595,803.72 | 32,881 | BMTVQS7 |
| 0.68% | GH | GUARDANT HEALTH INC | -- | $585,685.00 | 5,714 | BFXC911 |
| 0.66% | IONS | IONIS PHARMACEUTICALS INC | -- | $574,680.82 | 7,154 | BDJ0LS6 |
| 0.65% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $567,431.76 | 2,712 | BV9G6B8 |
| 0.65% | SNY | SANOFI-ADR | -- | $564,764.16 | 11,688 | 2964557 |
| 0.64% | MRNA | MODERNA INC | -- | $557,034.79 | 17,251 | BGSXTS3 |
| 0.64% | EXEL | EXELIXIS INC | -- | $551,955.62 | 11,842 | 2576941 |
| 0.60% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $518,283.78 | 8,477 | 2437071 |
| 0.57% | TEM | TEMPUS AI INC | -- | $494,137.20 | 7,635 | BSLSJJ0 |
| 0.55% | RNA | AVIDITY BIOSCIENCES INC | -- | $480,091.70 | 6,655 | BMWHPY1 |
| 0.52% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $454,857.48 | 2,684 | B4Q5ZN4 |
| 0.50% | ONC | BEONE MEDICINES LTD-ADR | -- | $434,124.80 | 1,390 | BYYWPW6 |
| 0.48% | BNTX | BIONTECH SE-ADR | -- | $420,240.96 | 4,464 | BK6H543 |
| 0.48% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $418,910.17 | 5,999 | BYQBFJ8 |
| 0.42% | CYTK | CYTOKINETICS INC | -- | $361,575.77 | 5,713 | BBBSBJ5 |
| 0.42% | -- | ABIVAX SA ADR USD 0.01 | -- | $360,678.45 | 2,607 | -- |
| 0.41% | HALO | HALOZYME THERAPEUTICS INC | -- | $355,061.84 | 5,194 | 2975098 |
| 0.40% | -- | CARIS LIFE SCIENCES INC COMMON STOCK USD 0.001 | -- | $348,936.00 | 12,462 | -- |
| 0.40% | AXSM | AXSOME THERAPEUTICS INC | -- | $343,381.13 | 2,227 | BYZR4X4 |
| 0.39% | NUVL | NUVALENT INC-A | -- | $334,407.70 | 3,190 | BMVBZD3 |
| 0.38% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $331,207.80 | 2,948 | BF2YWG4 |
| 0.37% | KRYS | KRYSTAL BIOTECH INC | -- | $324,554.16 | 1,281 | BD6JX35 |
| 0.35% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $304,681.65 | 1,105 | BQ721R4 |
| 0.32% | PCVX | VAXCYTE INC | -- | $276,628.66 | 5,786 | BKPVGH6 |
| 0.32% | PTCT | PTC THERAPEUTICS INC | -- | $275,524.20 | 3,546 | B17VCN9 |
| 0.31% | COGT | COGENT BIOSCIENCES INC | -- | $272,232.09 | 6,777 | BLR6XK8 |
| 0.31% | KYMR | KYMERA THERAPEUTICS INC | -- | $265,458.34 | 3,178 | BMPRZV5 |
| 0.28% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $244,983.53 | 2,761 | BDCBCD8 |
| 0.27% | CRSP | CRISPR THERAPEUTICS AG | -- | $237,188.46 | 4,201 | BDHF4K6 |
| 0.24% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $210,804.53 | 2,957 | BQS9486 |
| 0.24% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $207,973.59 | 7,473 | 2713317 |
| 0.24% | ALKS | ALKERMES PLC | -- | $207,863.04 | 7,296 | B3P6D26 |
| 0.24% | IMVT | IMMUNOVANT INC | -- | $207,122.40 | 7,740 | BJRFSB7 |
| 0.24% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $206,780.34 | 4,506 | BFZQ0L8 |
| 0.24% | ADMA | ADMA BIOLOGICS INC | -- | $204,878.88 | 10,512 | B9NSBM2 |
| 0.24% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $204,814.17 | 4,191 | BDD19F8 |
| 0.23% | INDV | INDIVIOR PLC | -- | $200,470.25 | 5,515 | BP0BQQ5 |
| 0.22% | FOLD | AMICUS THERAPEUTICS INC | -- | $193,653.88 | 13,628 | B19FQ48 |
| 0.22% | APGE | APOGEE THERAPEUTICS INC | -- | $187,220.60 | 2,422 | BM9HHL5 |
| 0.21% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $181,713.50 | 2,270 | BJDX8Y8 |
| 0.21% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $180,037.60 | 5,008 | BP8JSP4 |
| 0.21% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $178,219.20 | 13,880 | BFNF1D6 |
| 0.20% | LGND | LIGAND PHARMACEUTICALS | -- | $171,531.91 | 869 | 2501578 |
| 0.19% | ACLX | ARCELLX INC | -- | $167,312.54 | 2,554 | BPCJ1Q2 |
| 0.19% | TERN | TERNS PHARMACEUTICALS INC | -- | $165,247.87 | 3,979 | BMDJ0C9 |
| 0.18% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $158,567.10 | 5,410 | BKX9VD3 |
| 0.18% | GRAL | GRAIL INC | -- | $157,373.58 | 1,722 | BSLSSX7 |
| 0.18% | TARS | TARSUS PHARMACEUTICALS INC | -- | $153,993.75 | 1,875 | BMH5RL1 |
| 0.18% | VERA | VERA THERAPEUTICS INC | -- | $152,241.84 | 2,824 | BL55460 |
| 0.18% | XENE | XENON PHARMACEUTICALS INC | -- | $152,015.02 | 3,413 | BRJ3GY4 |
| 0.17% | VCYT | VERACYTE INC | -- | $150,091.24 | 3,497 | BFTWZY0 |
| 0.17% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $145,427.93 | 4,261 | BJ62Z18 |
| 0.16% | CGON | CG ONCOLOGY INC | -- | $142,537.95 | 3,559 | BRBCSP4 |
| 0.16% | TVTX | TRAVERE THERAPEUTICS INC | -- | $139,742.72 | 3,952 | BLFGJD5 |
| 0.16% | APLS | APELLIS PHARMACEUTICALS INC | -- | $138,694.16 | 5,588 | BYTQ6X1 |
| 0.16% | IDYA | IDEAYA BIOSCIENCES INC | -- | $137,107.52 | 3,872 | BK0VHF6 |
| 0.15% | IRON | DISC MEDICINE INC | -- | $133,059.94 | 1,667 | BMGJZJ8 |
| 0.15% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $130,981.43 | 2,533 | B72ZBG4 |
| 0.15% | MLYS | MINERALYS THERAPEUTICS INC | -- | $130,575.60 | 3,496 | BP9N0G0 |
| 0.15% | WVE | WAVE LIFE SCIENCES LTD | -- | $129,072.32 | 7,384 | BYZG9R0 |
| 0.15% | DYN | DYNE THERAPEUTICS INC | -- | $128,746.28 | 6,308 | BN15WD1 |
| 0.14% | BEAM | BEAM THERAPEUTICS INC | -- | $124,465.14 | 4,482 | BK6L288 |
| 0.14% | OCUL | OCULAR THERAPEUTIX INC | -- | $119,832.44 | 9,406 | BNZB1X8 |
| 0.13% | SYRE | SPYRE THERAPEUTICS INC | -- | $113,879.21 | 3,427 | BQBBDY8 |
| 0.13% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $112,945.25 | 6,743 | BJ5FZ74 |
| 0.13% | DNLI | DENALI THERAPEUTICS INC | -- | $108,895.18 | 6,478 | BD2B4V0 |
| 0.12% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $107,632.86 | 4,261 | BLB0YQ9 |
| 0.12% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $101,679.62 | 4,676 | BKY5JZ8 |
| 0.12% | SRPT | SAREPTA THERAPEUTICS INC | -- | $101,574.00 | 4,617 | B8DPDT7 |
| 0.12% | ZBIO | ZENAS BIOPHARMA INC | -- | $101,502.51 | 2,371 | BQB42H3 |
| 0.11% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $99,019.96 | 22,711 | BM9FJ13 |
| 0.11% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $97,791.36 | 2,544 | BKSGZN7 |
| 0.11% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $96,125.58 | 3,474 | BMZ4LN0 |
| 0.11% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $94,390.83 | 5,823 | BFWLC09 |
| 0.11% | IBRX | IMMUNITYBIO INC | -- | $91,360.50 | 43,505 | BNSP0B8 |
| 0.11% | TWST | TWIST BIOSCIENCE CORP | -- | $91,334.16 | 2,699 | BGKG6G7 |
| 0.10% | MAZE | MAZE THERAPEUTICS INC | -- | $89,887.50 | 2,125 | BSRK699 |
| 0.10% | ZYME | ZYMEWORKS INC | -- | $88,540.95 | 3,305 | BPCQZY9 |
| 0.10% | GMAB | GENMAB A/S -SP ADR | -- | $86,884.30 | 2,582 | BBC9WC7 |
| 0.10% | NRIX | NURIX THERAPEUTICS INC | -- | $86,361.33 | 4,477 | BMVLGP2 |
| 0.10% | SION | SIONNA THERAPEUTICS INC | -- | $85,620.24 | 1,971 | BQKXDX4 |
| 0.10% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $84,979.15 | 3,719 | BMX9K07 |
| 0.10% | TXG | 10X GENOMICS INC-CLASS A | -- | $84,909.00 | 5,146 | BKS3RS7 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $84,827.40 | 1,995 | BRXB0C0 |
| 0.10% | VCEL | VERICEL CORP | -- | $83,506.92 | 2,234 | BSBMN89 |
| 0.10% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $83,306.30 | 3,839 | BN7Q7R7 |
| 0.09% | MNKD | MANNKIND CORP | -- | $80,428.59 | 13,563 | BF081J4 |
| 0.09% | HROW | HARROW INC | -- | $80,409.40 | 1,636 | BHNDW86 |
| 0.09% | STOK | STOKE THERAPEUTICS INC | -- | $80,382.78 | 2,523 | BJQ05Z6 |
| 0.09% | ANIP | ANI PHARMACEUTICALS INC | -- | $80,084.16 | 992 | BCDWBX6 |
| 0.08% | -- | PHARVARIS NV COMMON STOCK USD 0.12 | -- | $73,129.65 | 2,829 | -- |
| 0.08% | FTRE | FORTREA HOLDINGS INC | -- | $73,090.71 | 4,081 | BRXYZ57 |
| 0.08% | TRVI | TREVI THERAPEUTICS INC | -- | $72,612.48 | 5,664 | BJH9ZN0 |
| 0.08% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $70,021.47 | 9,299 | 2100362 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $69,738.13 | 1,927 | BLCD809 |
| 0.08% | UPB | UPSTREAM BIO INC | -- | $69,724.27 | 2,387 | BRCFFK6 |
| 0.08% | ATAI | ATAI LIFE SCIENCES NV | -- | $69,461.86 | 16,042 | BN6M8F1 |
| 0.08% | TSHA | TAYSHA GENE THERAPIES INC | -- | $69,085.29 | 12,099 | BNC1BX1 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $68,194.60 | 1,396 | BX7RSN3 |
| 0.08% | ORKA | ORUKA THERAPEUTICS INC | -- | $67,795.98 | 2,138 | BKVF0J2 |
| 0.08% | EYPT | EYEPOINT INC | -- | $67,215.66 | 3,657 | BMGS7L1 |
| 0.08% | QURE | UNIQURE NV | -- | $66,519.18 | 2,751 | BJFSR88 |
| 0.08% | ALVO | ALVOTECH SA | -- | $66,503.06 | 13,826 | BPNTJ34 |
| 0.08% | NVCR | NOVOCURE LTD | -- | $65,633.42 | 4,946 | BYSS4X4 |
| 0.07% | RAPP | RAPPORT THERAPEUTICS INC | -- | $64,516.34 | 2,107 | BR3T9B6 |
| 0.07% | INVA | INNOVIVA INC | -- | $64,441.53 | 3,303 | BDDXF67 |
| 0.07% | KOD | KODIAK SCIENCES INC | -- | $64,315.35 | 2,343 | BFXC933 |
| 0.07% | MBX | MBX BIOSCIENCES INC | -- | $63,852.60 | 1,983 | BQXJKH2 |
| 0.07% | RLAY | RELAY THERAPEUTICS INC | -- | $63,613.05 | 7,655 | BN2R582 |
| 0.07% | PGEN | PRECIGEN INC | -- | $63,463.51 | 15,593 | BKM5C84 |
| 0.07% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $63,343.84 | 2,576 | BCBVTX1 |
| 0.07% | ARDX | ARDELYX INC | -- | $62,245.60 | 10,732 | BN89V40 |
| 0.07% | ANAB | ANAPTYSBIO INC | -- | $61,198.92 | 1,223 | BDRW1L7 |
| 0.07% | MNMD | MIND MEDICINE MINDMED INC | -- | $61,001.02 | 4,351 | BPQYY97 |
| 0.07% | TYRA | TYRA BIOSCIENCES INC | -- | $60,881.31 | 2,357 | BMVNDH9 |
| 0.07% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $59,715.81 | 4,851 | BPCK358 |
| 0.07% | SVRA | SAVARA INC | -- | $57,876.28 | 8,987 | BYXGN81 |
| 0.07% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $57,731.31 | 5,187 | BRJZSK0 |
| 0.06% | SEPN | SEPTERNA INC | -- | $55,838.94 | 1,978 | BQNKXX2 |
| 0.06% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $54,199.50 | 3,142 | BJLKVS6 |
| 0.06% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $53,693.50 | 2,030 | BNFWZS4 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $53,355.12 | 7,329 | BLR7H87 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $53,295.45 | 11,765 | BMFJJ97 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $51,817.80 | 1,289 | BKLCWZ3 |
| 0.06% | TNGX | TANGO THERAPEUTICS INC | -- | $50,744.97 | 5,949 | BP2P6L0 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $50,127.36 | 642 | BNSP8K3 |
| 0.06% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $49,445.88 | 17,534 | BF0DMK7 |
| 0.06% | ALMS | ALUMIS INC | -- | $49,166.30 | 4,294 | BPLQG36 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $49,084.68 | 5,388 | B8K7T65 |
| 0.06% | PCRX | PACIRA BIOSCIENCES INC | -- | $48,906.00 | 1,900 | B3X26D8 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $48,855.60 | 13,240 | BL53SR3 |
| 0.06% | NVAX | NOVAVAX INC | -- | $48,803.60 | 7,177 | BJDQXG4 |
| 0.06% | XNCR | XENCOR INC | -- | $48,792.38 | 3,154 | BGCYWN8 |
| 0.06% | URGN | UROGEN PHARMA LTD | -- | $48,391.20 | 2,068 | BZ7PJQ1 |
| 0.06% | SPRY | ARS PHARMACEUTICALS INC | -- | $48,156.98 | 4,366 | BMCR7V2 |
| 0.06% | NTLA | INTELLIA THERAPEUTICS INC | -- | $48,145.62 | 5,111 | BYZM6C2 |
| 0.05% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $47,396.48 | 2,876 | BP7KZP7 |
| 0.05% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $43,421.67 | 4,509 | BLB0YH0 |
| 0.05% | -- | RAPT THERAPEUTICS INC | -- | $43,329.60 | 1,224 | BTJZB49 |
| 0.05% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $43,325.13 | 2,621 | BMFD115 |
| 0.05% | ERAS | ERASCA INC | -- | $42,480.09 | 12,531 | BNLYBF3 |
| 0.05% | BCAX | BICARA THERAPEUTICS INC | -- | $42,471.00 | 2,420 | BQB42F1 |
| 0.05% | CRMD | CORMEDIX INC | -- | $41,690.40 | 3,480 | BJ0LT31 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $41,578.23 | 2,239 | BMNDK09 |
| 0.05% | MESO | MESOBLAST LTD- SPON ADR | -- | $41,565.54 | 2,166 | BQS7491 |
| 0.05% | KURA | KURA ONCOLOGY INC | -- | $41,390.44 | 3,836 | BYZD465 |
| 0.05% | ESPR | ESPERION THERAPEUTICS INC | -- | $40,968.92 | 10,559 | BBNBTD2 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $40,689.36 | 1,823 | BMGTLY5 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $39,756.60 | 8,495 | BZ0QMB7 |
| 0.04% | JANX | JANUX THERAPEUTICS INC | -- | $37,516.84 | 2,657 | BMFX8Y7 |
| 0.04% | GERN | GERON CORP | -- | $37,500.68 | 28,196 | 2370381 |
| 0.04% | VIR | VIR BIOTECHNOLOGY INC | -- | $36,808.55 | 6,145 | BK4PZ38 |
| 0.04% | ORIC | ORIC PHARMACEUTICALS INC | -- | $35,577.54 | 4,302 | BKVDFF7 |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $35,239.88 | 802 | BQD3J33 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $35,169.75 | 2,233 | BD06CS0 |
| 0.04% | LYEL | LYELL IMMUNOPHARMA INC | -- | $34,978.21 | 937 | BTNMG41 |
| 0.04% | -- | GH RESEARCH PLC COMMON STOCK USD 0.01 | -- | $34,935.00 | 2,740 | -- |
| 0.04% | ARVN | ARVINAS INC | -- | $34,554.66 | 2,837 | BDZ30Q0 |
| 0.04% | IVVD | INVIVYD INC | -- | $34,272.00 | 12,240 | BM8NHS1 |
| 0.04% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $33,763.17 | 903 | BL95N25 |
| 0.04% | REPL | REPLIMUNE GROUP INC | -- | $33,679.80 | 3,465 | BDDVW37 |
| 0.04% | LXEO | LEXEO THERAPEUTICS INC | -- | $33,658.56 | 3,224 | BQ6C357 |
| 0.04% | GOSS | GOSSAMER BIO INC | -- | $33,582.56 | 10,223 | BJ0CK86 |
| 0.04% | PSNL | PERSONALIS INC | -- | $32,989.56 | 3,918 | BJQ0608 |
| 0.04% | ANNX | ANNEXON INC | -- | $32,668.23 | 6,393 | BMVV9R5 |
| 0.04% | RGNX | REGENXBIO INC | -- | $32,086.60 | 2,236 | BZ0G875 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $31,633.43 | 5,389 | BYVQJ96 |
| 0.04% | CTMX | CYTOMX THERAPEUTICS INC | -- | $31,432.80 | 7,484 | BYWVTY5 |
| 0.03% | ZLAB | ZAI LAB LTD-ADR | -- | $30,222.92 | 1,729 | BD9GVY0 |
| 0.03% | PRME | PRIME MEDICINE INC | -- | $29,420.37 | 7,973 | BPBJFM7 |
| 0.03% | KROS | KEROS THERAPEUTICS INC | -- | $28,777.48 | 1,346 | BM7V485 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $28,676.18 | 4,162 | BMC3HS7 |
| 0.03% | VTYX | VENTYX BIOSCIENCES INC | -- | $28,588.64 | 3,152 | BMG99Y1 |
| 0.03% | FULC | FULCRUM THERAPEUTICS INC | -- | $28,178.10 | 2,390 | BJDX8Z9 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $27,977.85 | 3,555 | BFYQFJ2 |
| 0.03% | OMER | OMEROS CORP | -- | $27,405.00 | 3,132 | B4NB858 |
| 0.03% | CGEM | CULLINAN THERAPEUTICS INC | -- | $26,090.00 | 2,609 | BM90J52 |
| 0.03% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $24,313.63 | 3,299 | BYP80F1 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $24,269.70 | 13,335 | B4N8MH9 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $24,153.60 | 2,516 | BMFK3H6 |
| 0.03% | ABSI | ABSCI CORP | -- | $23,379.84 | 6,642 | BN94K69 |
| 0.03% | LENZ | LENZ THERAPEUTICS INC | -- | $23,341.98 | 1,382 | BQV0J03 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $23,063.85 | 7,185 | B3MZ6K5 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $22,567.22 | 2,378 | B91XRN2 |
| 0.02% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $21,214.11 | 2,487 | BLFBZ32 |
| 0.02% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $21,075.74 | 6,406 | BMCWKZ2 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $21,048.66 | 639 | B292NQ7 |
| 0.02% | BIOA | BIOAGE LABS INC | -- | $20,924.64 | 1,584 | BT9K6D8 |
| 0.02% | IMAB | I-MAB-SPONSORED ADR | -- | $20,664.00 | 4,592 | BKRRKY7 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $20,301.90 | 3,441 | BQHN6C7 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $20,030.25 | 1,275 | B9L5200 |
| 0.02% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $19,939.60 | 2,524 | BKLXFX5 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $19,705.49 | 3,163 | 2107437 |
| 0.02% | ETON | ETON PHARMACEUTICALS INC | -- | $19,611.75 | 1,185 | BGL0JK3 |
| 0.02% | EOLS | EVOLUS INC | -- | $19,497.03 | 2,863 | BDRJH21 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $18,436.00 | 4,609 | BFY7DC4 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $18,224.28 | 2,852 | BMVBZF5 |
| 0.02% | KMDA | KAMADA LTD | -- | $18,014.36 | 2,548 | B2Q9833 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $17,943.44 | 1,688 | BP81RK8 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $17,852.40 | 2,610 | B12W3P6 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $17,623.37 | 827 | BPBPCG8 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $17,218.32 | 1,939 | BSMLR16 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $16,942.20 | 2,805 | BP81R42 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $16,491.00 | 4,780 | BDFKQ07 |
| 0.02% | PEPG | PEPGEN INC | -- | $16,217.58 | 3,037 | BMTX3D7 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $14,779.80 | 3,780 | BMXNGZ6 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $14,718.58 | 3,946 | BYTYP72 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $14,530.40 | 8,860 | BFMLGR4 |
| 0.02% | CADL | CANDEL THERAPEUTICS INC | -- | $14,234.75 | 2,425 | BP0TQC5 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $14,185.36 | 2,044 | BKDQKM6 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $13,970.25 | 4,435 | BZC0D70 |
| 0.02% | ACRS | ACLARIS THERAPEUTICS INC | -- | $13,879.40 | 4,786 | BYV2W40 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $13,863.90 | 2,498 | BMF7DT9 |
| 0.02% | NGNE | NEUROGENE INC | -- | $13,734.72 | 684 | BS2F741 |
| 0.02% | AARD | AARDVARK THERAPEUTICS INC | -- | $13,612.30 | 962 | BTXQTX3 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $13,499.36 | 9,926 | BFZNYB7 |
| 0.02% | -- | JYONG BIOTECH LTD COMMON STOCK USD 0.00001 | -- | $13,499.16 | 3,358 | -- |
| 0.02% | LFCR | LIFECORE BIOMEDICAL INC | -- | $13,339.30 | 1,655 | 2517058 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $13,155.66 | 2,226 | B7F2TY6 |
| 0.01% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $13,003.98 | 2,074 | BL5B6Z1 |
| 0.01% | NMRA | NEUMORA THERAPEUTICS INC | -- | $12,915.00 | 7,380 | BN4JN37 |
| 0.01% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $12,556.20 | 1,020 | BPRBTY7 |
| 0.01% | OABI | OMNIAB INC | -- | $12,334.52 | 6,358 | BN13S71 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $11,836.93 | 3,451 | BLN9Z50 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $10,799.02 | 2,494 | BPRB2N7 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $10,623.51 | 8,637 | BNR5QT9 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $10,397.94 | 2,606 | BY7RB53 |
| 0.01% | -- | VOR BIOPHARMA INC COMMON STOCK USD 0.0001 | -- | $10,066.32 | 744 | -- |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $9,692.40 | 2,364 | BP7L561 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $9,443.28 | 4,312 | BZ8FPH3 |
| 0.01% | HUMA | HUMACYTE INC | -- | $9,347.36 | 8,272 | BMYTJP4 |
| 0.01% | CABA | CABALETTA BIO INC | -- | $9,269.36 | 4,252 | BK5MWR1 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $8,647.62 | 4,281 | BKX9NQ0 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $8,227.69 | 1,369 | BP2NYN2 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $8,069.65 | 1,255 | BKC9SX3 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $7,047.48 | 5,339 | BRK0149 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $6,852.48 | 4,128 | BNYJR68 |
| 0.01% | CDXS | CODEXIS INC | -- | $6,583.50 | 3,990 | B5LL2C2 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $6,418.35 | 2,517 | BKTV702 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $6,332.76 | 4,308 | BNNXX18 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $5,171.33 | 7,354 | BNNXX52 |
| -- | PYXS | PYXIS ONCOLOGY INC | -- | $2,997.50 | 2,750 | BLBR8D5 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 36.87% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 31,983,419 | -- | 5,511 | -- |
| 32.64% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 28,309,766 | -- | 4,878 | -- |
| 25.47% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 22,088,349 | -- | 3,806 | -- |
| 16.62% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,416,043 | -- | 2,484 | -- |
| 15.38% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 13,342,384 | -- | 2,299 | -- |
| 4.24% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,673,653 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $26,857,466.62 | 26,857,467 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
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