BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 1/31/2026
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 4.27% | 16.53% | 65.39% | 4.27% | 51.38% | 11.58% | -2.47% | 6.91% | 16.64% | 04/07/2010 |
| BIB Market Price | 4.19% | 16.41% | 65.44% | 4.19% | 51.07% | 11.50% | -2.49% | 6.94% | 16.64% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 2/27/2026- NAV $88.18
- NAV Change $+1.51
- Market Price $88.15
- Market Price Change $+1.50
- Trading Volume (M) 9,548
- 30-Day Median Bid Ask Spread 0.27%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 2/27/2026- NAV $88.18
- NAV Change $+1.51
- Market Price $88.15
- Market Price Change $+1.50
- Trading Volume (M) 9,548
- 30-Day Median Bid Ask Spread 0.27%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 12/31/2025
Holdings
as of 2/27/2026
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 6.48% | GILD | GILEAD SCIENCES INC | -- | $5,943,700.80 | 39,904 | 2369174 |
| 6.27% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,753,788.23 | 11,581 | 2931034 |
| 6.15% | AMGN | AMGEN INC | -- | $5,642,293.76 | 14,536 | 2023607 |
| 4.06% | REGN | REGENERON PHARMACEUTICALS | -- | $3,727,784.23 | 4,769 | 2730190 |
| 2.21% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,031,144.92 | 6,101 | B00FWN1 |
| 1.60% | INSM | INSMED INC | -- | $1,470,601.84 | 9,848 | 2614487 |
| 1.42% | BIIB | BIOGEN INC | -- | $1,299,388.68 | 6,774 | 2455965 |
| 1.12% | ARGX | ARGENX SE - ADR | -- | $1,030,740.48 | 1,344 | BDVLM39 |
| 1.09% | UTHR | UNITED THERAPEUTICS CORP | -- | $1,001,753.20 | 1,988 | 2430412 |
| 1.05% | MRNA | MODERNA INC | -- | $966,349.23 | 18,039 | BGSXTS3 |
| 1.03% | ILMN | ILLUMINA INC | -- | $948,615.30 | 7,055 | 2613990 |
| 1.01% | ROIV | ROIVANT SCIENCES LTD | -- | $929,379.16 | 32,114 | BMW4NZ9 |
| 1.00% | INCY | INCYTE CORP | -- | $918,012.55 | 9,065 | 2471950 |
| 0.99% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $911,677.09 | 19,729 | BMVP7Y0 |
| 0.99% | RVMD | REVOLUTION MEDICINES INC | -- | $910,732.54 | 8,927 | BL71K91 |
| 0.87% | VTRS | VIATRIS INC | -- | $794,022.19 | 53,183 | BMWS3X9 |
| 0.72% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $661,972.50 | 2,835 | BV9G6B8 |
| 0.66% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $608,879.00 | 4,604 | 2623911 |
| 0.66% | IONS | IONIS PHARMACEUTICALS INC | -- | $606,920.85 | 7,479 | BDJ0LS6 |
| 0.65% | SNY | SANOFI-ADR | -- | $594,576.54 | 12,219 | 2964557 |
| 0.64% | BBIO | BRIDGEBIO PHARMA INC | -- | $591,472.56 | 8,897 | BK1KWG8 |
| 0.64% | MEDP | MEDPACE HOLDINGS INC | -- | $587,739.76 | 1,301 | BDCBC61 |
| 0.62% | SMMT | SUMMIT THERAPEUTICS INC | -- | $570,281.25 | 34,375 | BMTVQS7 |
| 0.61% | GH | GUARDANT HEALTH INC | -- | $560,958.60 | 5,974 | BFXC911 |
| 0.60% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $547,606.83 | 8,871 | 2437071 |
| 0.59% | EXEL | EXELIXIS INC | -- | $545,506.86 | 12,381 | 2576941 |
| 0.58% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $533,196.12 | 2,806 | B4Q5ZN4 |
| 0.56% | BNTX | BIONTECH SE-ADR | -- | $514,663.87 | 4,669 | BK6H543 |
| 0.50% | ONC | BEONE MEDICINES LTD-ADR | -- | $460,903.46 | 1,454 | BYYWPW6 |
| 0.49% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $452,736.00 | 1,048 | BD59BS7 |
| 0.49% | IBRX | IMMUNITYBIO INC | -- | $444,804.18 | 45,481 | BNSP0B8 |
| 0.46% | TEM | TEMPUS AI INC-CL A | -- | $425,041.50 | 7,982 | BSLSJJ0 |
| 0.43% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $396,766.17 | 6,271 | BYQBFJ8 |
| 0.42% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $388,946.25 | 1,155 | BQ721R4 |
| 0.42% | AXSM | AXSOME THERAPEUTICS INC | -- | $381,372.03 | 2,327 | BYZR4X4 |
| 0.41% | HALO | HALOZYME THERAPEUTICS INC | -- | $377,547.90 | 5,430 | 2975098 |
| 0.41% | PCVX | VAXCYTE INC | -- | $373,156.56 | 6,044 | BKPVGH6 |
| 0.40% | KRYS | KRYSTAL BIOTECH INC | -- | $369,081.96 | 1,339 | BD6JX35 |
| 0.38% | CYTK | CYTOKINETICS INC | -- | $351,294.12 | 5,646 | BBBSBJ5 |
| 0.37% | NUVL | NUVALENT INC-A | -- | $340,003.25 | 3,335 | BMVBZD3 |
| 0.36% | ABVX | ABIVAX SA-ADR | -- | $330,609.28 | 2,726 | BLC89B2 |
| 0.33% | ACLX | ARCELLX INC | -- | $303,819.30 | 2,670 | BPCJ1Q2 |
| 0.33% | KYMR | KYMERA THERAPEUTICS INC | -- | $303,464.70 | 3,322 | BMPRZV5 |
| 0.31% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $285,793.86 | 3,082 | BF2YWG4 |
| 0.30% | COGT | COGENT BIOSCIENCES INC | -- | $275,368.80 | 7,088 | BLR6XK8 |
| 0.29% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $265,834.96 | 2,887 | BDCBCD8 |
| 0.29% | CRSP | CRISPR THERAPEUTICS AG | -- | $264,616.00 | 4,400 | BDHF4K6 |
| 0.29% | CAI | CARIS LIFE SCIENCES INC | -- | $262,404.06 | 13,029 | BT18HP9 |
| 0.28% | PTCT | PTC THERAPEUTICS INC | -- | $252,780.33 | 3,707 | B17VCN9 |
| 0.25% | ALKS | ALKERMES PLC | -- | $229,482.40 | 7,624 | B3P6D26 |
| 0.24% | IMVT | IMMUNOVANT INC | -- | $224,446.62 | 8,094 | BJRFSB7 |
| 0.24% | CGON | CG ONCOLOGY INC | -- | $219,030.00 | 3,725 | BRBCSP4 |
| 0.24% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $219,004.17 | 2,373 | BJDX8Y8 |
| 0.23% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $208,511.70 | 4,710 | BFZQ0L8 |
| 0.22% | FOLD | AMICUS THERAPEUTICS INC | -- | $204,729.39 | 14,247 | B19FQ48 |
| 0.22% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $200,465.96 | 14,516 | BFNF1D6 |
| 0.21% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $194,356.28 | 3,086 | BQS9486 |
| 0.21% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $191,862.72 | 7,812 | 2713317 |
| 0.21% | INDV | INDIVIOR PHARMACEUTICALS INC | -- | $188,565.36 | 5,763 | BTZRLN8 |
| -- | -- | NEWAMSTERDAM PHARMA CO NV | -- | $185,668.56 | 5,236 | BP8JSP4 |
| 0.20% | LGND | LIGAND PHARMACEUTICALS | -- | $180,263.79 | 909 | 2501578 |
| 0.20% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $180,100.20 | 4,382 | BDD19F8 |
| 0.20% | ERAS | ERASCA INC | -- | $178,959.66 | 13,101 | BNLYBF3 |
| 0.19% | APGE | APOGEE THERAPEUTICS INC | -- | $177,240.00 | 2,532 | BM9HHL5 |
| 0.19% | TERN | TERNS PHARMACEUTICALS INC | -- | $175,219.20 | 4,160 | BMDJ0C9 |
| 0.19% | ADMA | ADMA BIOLOGICS INC | -- | $171,114.30 | 10,990 | B9NSBM2 |
| 0.17% | XENE | XENON PHARMACEUTICALS INC | -- | $154,244.64 | 3,568 | BRJ3GY4 |
| 0.17% | SYRE | SPYRE THERAPEUTICS INC | -- | $154,104.83 | 3,583 | BQBBDY8 |
| 0.17% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $152,542.32 | 5,656 | BKX9VD3 |
| 0.16% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $148,821.16 | 4,889 | BKY5JZ8 |
| 0.16% | TARS | TARSUS PHARMACEUTICALS INC | -- | $148,094.72 | 1,961 | BMH5RL1 |
| 0.16% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $144,925.04 | 2,648 | B72ZBG4 |
| 0.16% | DNLI | DENALI THERAPEUTICS INC | -- | $143,430.96 | 6,772 | BD2B4V0 |
| 0.15% | VCYT | VERACYTE INC | -- | $133,553.50 | 3,650 | BFTWZY0 |
| 0.15% | BEAM | BEAM THERAPEUTICS INC | -- | $133,335.10 | 4,685 | BK6L288 |
| 0.15% | ALMS | ALUMIS INC | -- | $133,278.41 | 4,489 | BPLQG36 |
| 0.14% | TWST | TWIST BIOSCIENCE CORP | -- | $132,455.16 | 2,823 | BGKG6G7 |
| 0.14% | IDYA | IDEAYA BIOSCIENCES INC | -- | $130,345.60 | 4,048 | BK0VHF6 |
| 0.14% | TXG | 10X GENOMICS INC-CLASS A | -- | $123,985.95 | 5,379 | BKS3RS7 |
| 0.13% | TVTX | TRAVERE THERAPEUTICS INC | -- | $123,062.49 | 4,131 | BLFGJD5 |
| 0.13% | APLS | APELLIS PHARMACEUTICALS INC | -- | $122,385.44 | 5,839 | BYTQ6X1 |
| 0.13% | VERA | VERA THERAPEUTICS INC | -- | $120,330.50 | 2,950 | BL55460 |
| 0.13% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $119,661.30 | 4,455 | BLB0YQ9 |
| 0.13% | IRON | DISC MEDICINE INC | -- | $116,185.28 | 1,744 | BMGJZJ8 |
| 0.12% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $112,924.98 | 7,049 | BJ5FZ74 |
| 0.12% | WVE | WAVE LIFE SCIENCES LTD | -- | $107,581.39 | 7,723 | BYZG9R0 |
| 0.12% | MLYS | MINERALYS THERAPEUTICS INC | -- | $106,916.04 | 3,654 | BP9N0G0 |
| 0.11% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $104,202.45 | 4,455 | BJ62Z18 |
| 0.11% | DYN | DYNE THERAPEUTICS INC | -- | $103,013.90 | 6,595 | BN15WD1 |
| 0.11% | MAZE | MAZE THERAPEUTICS INC | -- | $101,300.98 | 2,222 | BSRK699 |
| 0.10% | STOK | STOKE THERAPEUTICS INC | -- | $96,049.58 | 2,638 | BJQ05Z6 |
| 0.10% | GRAL | GRAIL INC | -- | $95,814.00 | 1,800 | BSLSSX7 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $92,806.14 | 2,086 | BRXB0C0 |
| 0.10% | HROW | HARROW INC | -- | $92,647.80 | 1,710 | BHNDW86 |
| 0.10% | OCUL | OCULAR THERAPEUTIX INC | -- | $87,942.78 | 9,837 | BNZB1X8 |
| 0.10% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $87,894.40 | 3,632 | BMZ4LN0 |
| 0.10% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $87,143.94 | 4,014 | BN7Q7R7 |
| 0.10% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $87,136.81 | 23,743 | BM9FJ13 |
| 0.09% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $86,266.96 | 6,088 | BFWLC09 |
| 0.09% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $85,067.50 | 9,722 | 2100362 |
| 0.09% | PHVS | PHARVARIS NV | -- | $83,977.62 | 2,958 | BMZ2X38 |
| 0.09% | VCEL | VERICEL CORP | -- | $83,312.80 | 2,335 | BSBMN89 |
| 0.09% | RLAY | RELAY THERAPEUTICS INC | -- | $82,110.78 | 8,003 | BN2R582 |
| 0.09% | TYRA | TYRA BIOSCIENCES INC | -- | $82,075.84 | 2,464 | BMVNDH9 |
| 0.09% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $81,380.29 | 2,741 | BMFD115 |
| 0.09% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $81,379.16 | 2,692 | BCBVTX1 |
| 0.09% | SRPT | SAREPTA THERAPEUTICS INC | -- | $81,084.88 | 4,838 | B8DPDT7 |
| 0.09% | ZYME | ZYMEWORKS INC | -- | $80,490.24 | 3,456 | BPCQZY9 |
| 0.09% | GMAB | GENMAB A/S -SP ADR | -- | $79,458.56 | 2,699 | BBC9WC7 |
| 0.09% | DFTX | DEFINIUM THERAPEUTICS INC | -- | $79,362.60 | 4,548 | BV2DHY6 |
| 0.09% | INVA | INNOVIVA INC | -- | $79,280.88 | 3,453 | BDDXF67 |
| 0.08% | ORKA | ORUKA THERAPEUTICS INC | -- | $76,940.76 | 2,236 | BKVF0J2 |
| 0.08% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $76,927.07 | 5,071 | BPCK358 |
| 0.08% | ANIP | ANI PHARMACEUTICALS INC | -- | $76,634.30 | 1,037 | BCDWBX6 |
| 0.08% | NVAX | NOVAVAX INC | -- | $76,090.56 | 7,504 | BJDQXG4 |
| 0.08% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $75,916.40 | 2,660 | BKSGZN7 |
| 0.08% | SION | SIONNA THERAPEUTICS INC | -- | $75,308.94 | 2,061 | BQKXDX4 |
| 0.08% | NRIX | NURIX THERAPEUTICS INC | -- | $74,739.60 | 4,680 | BMVLGP2 |
| 0.08% | RAPT | RAPT THERAPEUTICS INC | -- | $74,156.42 | 1,279 | BTJZB49 |
| 0.08% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $73,872.00 | 3,888 | BMX9K07 |
| 0.08% | NTLA | INTELLIA THERAPEUTICS INC | -- | $73,695.44 | 5,348 | BYZM6C2 |
| 0.08% | ARDX | ARDELYX INC | -- | $73,491.00 | 11,220 | BN89V40 |
| 0.08% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $70,753.80 | 18,330 | BF0DMK7 |
| 0.08% | NVCR | NOVOCURE LTD | -- | $70,687.57 | 5,171 | BYSS4X4 |
| 0.08% | TRVI | TREVI THERAPEUTICS INC | -- | $70,578.32 | 5,921 | BJH9ZN0 |
| 0.08% | ANAB | ANAPTYSBIO INC | -- | $70,353.90 | 1,278 | BDRW1L7 |
| 0.08% | TNGX | TANGO THERAPEUTICS INC | -- | $69,279.66 | 6,219 | BP2P6L0 |
| 0.07% | MBX | MBX BIOSCIENCES INC | -- | $67,476.15 | 2,073 | BQXJKH2 |
| 0.07% | EYPT | EYEPOINT INC | -- | $67,114.32 | 3,822 | BMGS7L1 |
| 0.07% | KOD | KODIAK SCIENCES INC | -- | $65,660.00 | 2,450 | BFXC933 |
| 0.07% | ZBIO | ZENAS BIOPHARMA INC | -- | $65,295.30 | 2,478 | BQB42H3 |
| 0.07% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $65,084.50 | 2,015 | BLCD809 |
| 0.07% | RAPP | RAPPORT THERAPEUTICS INC | -- | $63,895.03 | 2,201 | BR3T9B6 |
| 0.07% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $62,978.74 | 3,449 | BYP80F1 |
| 0.07% | PGEN | PRECIGEN INC | -- | $61,921.02 | 16,338 | BKM5C84 |
| 0.07% | ATAI | ATAIBECKLEY INC | -- | $60,875.10 | 16,770 | BWJDYK1 |
| 0.07% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $60,838.20 | 1,460 | BX7RSN3 |
| 0.07% | ORIC | ORIC PHARMACEUTICALS INC | -- | $60,484.65 | 4,497 | BKVDFF7 |
| 0.07% | SEPN | SEPTERNA INC | -- | $59,984.34 | 2,067 | BQNKXX2 |
| 0.06% | VIR | VIR BIOTECHNOLOGY INC | -- | $58,394.16 | 6,424 | BK4PZ38 |
| 0.06% | ALVO | ALVOTECH SA | -- | $57,671.46 | 14,454 | BPNTJ34 |
| 0.06% | TSHA | TAYSHA GENE THERAPIES INC | -- | $57,295.44 | 12,648 | BNC1BX1 |
| 0.06% | SVRA | SAVARA INC | -- | $56,557.90 | 9,395 | BYXGN81 |
| 0.06% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $53,374.25 | 3,007 | BP7KZP7 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $51,783.00 | 12,300 | BMFJJ97 |
| 0.06% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $51,642.14 | 946 | BL95N25 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $51,260.30 | 5,633 | B8K7T65 |
| 0.05% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $50,254.60 | 4,741 | BLB0YH0 |
| 0.05% | ABCL | ABCELLERA BIOLOGICS INC | -- | $49,897.42 | 13,822 | BL53SR3 |
| 0.05% | INBX | INHIBRX BIOSCIENCES INC | -- | $49,815.36 | 672 | BNSP8K3 |
| 0.05% | GERN | GERON CORP | -- | $49,519.68 | 29,476 | 2370381 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $46,915.40 | 2,162 | BZ7PJQ1 |
| 0.05% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $46,891.44 | 7,662 | BLR7H87 |
| 0.05% | MNKD | MANNKIND CORP | -- | $46,510.40 | 14,180 | BF081J4 |
| 0.05% | VTYX | VENTYX BIOSCIENCES INC | -- | $46,031.15 | 3,295 | BMG99Y1 |
| 0.05% | FTRE | FORTREA HOLDINGS INC | -- | $45,731.52 | 4,266 | BRXYZ57 |
| 0.05% | QURE | UNIQURE NV | -- | $44,967.51 | 2,877 | BJFSR88 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $43,780.82 | 1,906 | BMGTLY5 |
| 0.05% | PCRX | PACIRA BIOSCIENCES INC | -- | $43,513.26 | 1,986 | B3X26D8 |
| 0.05% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $42,928.06 | 2,122 | BNFWZS4 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $42,705.00 | 2,340 | BMNDK09 |
| 0.05% | GHRS | GH RESEARCH PLC | -- | $42,530.40 | 2,864 | BP6C0S2 |
| 0.05% | BCAX | BICARA THERAPEUTICS INC | -- | $42,453.40 | 2,530 | BQB42F1 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $42,353.92 | 4,564 | BMCR7V2 |
| 0.05% | CGEM | CULLINAN THERAPEUTICS INC | -- | $42,284.00 | 2,728 | BM90J52 |
| 0.05% | XNCR | XENCOR INC | -- | $42,115.46 | 3,298 | BGCYWN8 |
| 0.05% | CTMX | CYTOMX THERAPEUTICS INC | -- | $42,009.51 | 7,823 | BYWVTY5 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $41,385.46 | 8,881 | BZ0QMB7 |
| 0.04% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $41,259.60 | 3,285 | BJLKVS6 |
| 0.04% | CSTL | CASTLE BIOSCIENCES INC | -- | $39,860.36 | 1,348 | BKLCWZ3 |
| 0.04% | OMER | OMEROS CORP | -- | $39,451.70 | 3,274 | B4NB858 |
| 0.04% | ARVN | ARVINAS INC | -- | $39,345.55 | 2,965 | BDZ30Q0 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $38,507.70 | 8,335 | BPBJFM7 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $37,997.52 | 2,334 | BD06CS0 |
| 0.04% | JANX | JANUX THERAPEUTICS INC | -- | $37,794.97 | 2,777 | BMFX8Y7 |
| 0.04% | ANNX | ANNEXON INC | -- | $37,424.80 | 6,683 | BMVV9R5 |
| 0.04% | PSNL | PERSONALIS INC | -- | $37,155.06 | 4,101 | BJQ0608 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $36,977.30 | 11,038 | BBNBTD2 |
| 0.04% | BIOA | BIOAGE LABS INC | -- | $36,879.12 | 1,656 | BT9K6D8 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $35,884.40 | 2,264 | BQS7491 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $35,077.14 | 4,018 | BYZD465 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $34,749.76 | 1,808 | BD9GVY0 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $30,021.90 | 4,351 | BMC3HS7 |
| 0.03% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $29,112.12 | 838 | BQD3J33 |
| 0.03% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $28,848.06 | 10,377 | BFZNYB7 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $28,100.52 | 3,717 | BFYQFJ2 |
| 0.03% | REPL | REPLIMUNE GROUP INC | -- | $27,708.30 | 3,622 | BDDVW37 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $27,457.20 | 2,630 | BMFK3H6 |
| 0.03% | NMRA | NEUMORA THERAPEUTICS INC | -- | $26,925.35 | 7,715 | BN4JN37 |
| 0.03% | CRMD | CORMEDIX INC | -- | $25,938.94 | 3,638 | BJ0LT31 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $25,691.04 | 7,512 | B3MZ6K5 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $25,483.08 | 2,638 | BKLXFX5 |
| 0.03% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $24,999.90 | 4,990 | BDFKQ07 |
| 0.03% | VNDA | VANDA PHARMACEUTICALS INC | -- | $24,315.39 | 2,729 | B12W3P6 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $24,196.60 | 3,370 | BQ6C357 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $23,837.76 | 6,696 | BMCWKZ2 |
| 0.03% | LYEL | LYELL IMMUNOPHARMA INC | -- | $23,496.00 | 979 | BTNMG41 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $23,420.88 | 13,941 | B4N8MH9 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $23,218.00 | 2,600 | BLFBZ32 |
| 0.03% | KMDA | KAMADA LTD | -- | $23,176.80 | 2,664 | B2Q9833 |
| 0.02% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $22,532.00 | 5,633 | BYVQJ96 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $22,484.88 | 668 | B292NQ7 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $22,343.58 | 3,598 | BQHN6C7 |
| 0.02% | IVVD | INVIVYD INC | -- | $21,625.24 | 12,796 | BM8NHS1 |
| 0.02% | PRTA | PROTHENA CORP PLC | -- | $21,544.95 | 2,485 | B91XRN2 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $21,396.29 | 3,307 | 2107437 |
| 0.02% | RGNX | REGENXBIO INC | -- | $21,126.48 | 2,337 | BZ0G875 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $21,056.45 | 1,765 | BP81RK8 |
| 0.02% | ETON | ETON PHARMACEUTICALS INC | -- | $21,050.61 | 1,239 | BGL0JK3 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $20,990.43 | 3,953 | BMXNGZ6 |
| 0.02% | FULC | FULCRUM THERAPEUTICS INC | -- | $20,941.62 | 2,499 | BJDX8Z9 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $20,769.89 | 4,819 | BFY7DC4 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $20,260.80 | 864 | BPBPCG8 |
| 0.02% | KROS | KEROS THERAPEUTICS INC | -- | $19,951.14 | 1,406 | BM7V485 |
| 0.02% | PEPG | PEPGEN INC | -- | $19,748.50 | 3,175 | BMTX3D7 |
| 0.02% | LENZ | LENZ THERAPEUTICS INC | -- | $19,493.05 | 1,445 | BQV0J03 |
| 0.02% | UPB | UPSTREAM BIO INC | -- | $19,161.60 | 2,495 | BRCFFK6 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $19,047.60 | 1,332 | B9L5200 |
| 0.02% | ABSI | ABSCI CORP | -- | $19,026.56 | 6,944 | BN94K69 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $18,273.75 | 4,125 | BYTYP72 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $17,269.48 | 2,932 | BP81R42 |
| 0.02% | AVIR | ATEA PHARMACEUTICALS INC | -- | $16,880.76 | 3,607 | BLN9Z50 |
| 0.02% | NGNE | NEUROGENE INC | -- | $16,795.35 | 715 | BS2F741 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $16,608.83 | 2,023 | BSMLR16 |
| 0.02% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $16,367.78 | 1,067 | BPRBTY7 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $15,838.02 | 9,262 | BFMLGR4 |
| 0.02% | NBP | NOVABRIDGE BIOSCIENCES | -- | $15,747.28 | 4,801 | BKRRKY7 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $14,875.19 | 2,981 | BMVBZF5 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $14,830.48 | 2,611 | BMF7DT9 |
| 0.02% | CABA | CABALETTA BIO INC | -- | $14,757.40 | 4,445 | BK5MWR1 |
| 0.02% | ACRS | ACLARIS THERAPEUTICS INC | -- | $14,358.61 | 5,003 | BYV2W40 |
| 0.01% | ACIU | AC IMMUNE SA | -- | $13,583.48 | 4,636 | BZC0D70 |
| 0.01% | CADL | CANDEL THERAPEUTICS INC | -- | $13,308.75 | 2,535 | BP0TQC5 |
| 0.01% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $13,258.20 | 2,326 | B7F2TY6 |
| 0.01% | EOLS | EVOLUS INC | -- | $12,869.90 | 2,993 | BDRJH21 |
| 0.01% | AARD | AARDVARK THERAPEUTICS INC | -- | $12,552.45 | 1,005 | BTXQTX3 |
| 0.01% | LFCR | LIFECORE BIOMEDICAL INC | -- | $12,456.00 | 1,730 | 2517058 |
| 0.01% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $12,239.28 | 2,136 | BKDQKM6 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $12,082.50 | 4,475 | BKX9NQ0 |
| 0.01% | VOR | VOR BIOPHARMA INC | -- | $12,012.32 | 778 | BRJJYT3 |
| 0.01% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $11,799.36 | 2,169 | BL5B6Z1 |
| 0.01% | OABI | OMNIAB INC | -- | $11,432.84 | 6,647 | BN13S71 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $11,418.66 | 2,607 | BPRB2N7 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $11,156.10 | 2,721 | BY7RB53 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $10,797.76 | 1,312 | BKC9SX3 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $9,917.60 | 4,508 | BZ8FPH3 |
| 0.01% | HUMA | HUMACYTE INC | -- | $9,641.41 | 8,647 | BMYTJP4 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $9,320.27 | 5,581 | BRK0149 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $8,636.29 | 9,030 | BNR5QT9 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $8,200.40 | 4,316 | BNYJR68 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $8,176.72 | 1,432 | BP2NYN2 |
| 0.01% | MENS | JYONG BIOTECH LTD | -- | $7,513.54 | 3,511 | BPTK6Z2 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $6,498.57 | 2,631 | BKTV702 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $6,375.18 | 2,471 | BP7L561 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $6,170.48 | 4,504 | BNNXX18 |
| -- | GOSS | GOSSAMER BIO INC | -- | $4,540.91 | 10,687 | BJ0CK86 |
| -- | TNYA | TENAYA THERAPEUTICS INC | -- | $4,319.12 | 7,688 | BNNXX52 |
| -- | PYXS | PYXIS ONCOLOGY INC | -- | $4,226.25 | 2,875 | BLBR8D5 |
| -- | CDXS | CODEXIS INC | -- | $4,212.71 | 4,171 | B5LL2C2 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $20.47 | 01 | BTFHQP5 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 37,329,254 | -- | 6,179 | -- |
| -- | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 25,923,261 | -- | 4,291 | -- |
| -- | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 23,114,052 | -- | 3,826 | -- |
| -- | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 15,943,017 | -- | 2,639 | -- |
| -- | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 15,006,614 | -- | 2,484 | -- |
| -- | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,824,149 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $29,830,096.70 | 29,830,097 | -- |
Index
as of 12/31/2025
- Total Number of Companies262
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$7.32 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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