BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 1/31/2026
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 4.27% | 16.53% | 65.39% | 4.27% | 51.38% | 11.58% | -2.47% | 6.91% | 16.64% | 04/07/2010 |
| BIB Market Price | 4.19% | 16.41% | 65.44% | 4.19% | 51.07% | 11.50% | -2.49% | 6.94% | 16.64% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 2/24/2026- NAV $88.86
- NAV Change $+1.37
- Market Price $88.85
- Market Price Change $+1.48
- Trading Volume (M) 5,599
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 2/24/2026- NAV $88.86
- NAV Change $+1.37
- Market Price $88.85
- Market Price Change $+1.48
- Trading Volume (M) 5,599
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 12/31/2025
Holdings
as of 2/23/2026
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 6.60% | GILD | GILEAD SCIENCES INC | -- | $6,062,571.29 | 40,463 | 2369174 |
| 6.15% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,648,500.43 | 11,743 | 2931034 |
| 6.09% | AMGN | AMGEN INC | -- | $5,592,271.38 | 14,739 | 2023607 |
| 4.14% | REGN | REGENERON PHARMACEUTICALS | -- | $3,806,125.44 | 4,836 | 2730190 |
| 2.22% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,037,359.10 | 6,186 | B00FWN1 |
| 1.73% | INSM | INSMED INC | -- | $1,588,073.58 | 9,986 | 2614487 |
| 1.47% | BIIB | BIOGEN INC | -- | $1,348,659.46 | 6,869 | 2455965 |
| 1.23% | ARGX | ARGENX SE - ADR | -- | $1,126,178.75 | 1,363 | BDVLM39 |
| 1.04% | UTHR | UNITED THERAPEUTICS CORP | -- | $956,632.32 | 2,016 | 2430412 |
| 1.02% | RVMD | REVOLUTION MEDICINES INC | -- | $938,601.88 | 9,052 | BL71K91 |
| 1.01% | INCY | INCYTE CORP | -- | $926,967.24 | 9,192 | 2471950 |
| 1.00% | MRNA | MODERNA INC | -- | $919,904.68 | 18,292 | BGSXTS3 |
| 0.99% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $909,627.35 | 20,005 | BMVP7Y0 |
| 0.98% | ROIV | ROIVANT SCIENCES LTD | -- | $903,976.64 | 32,564 | BMW4NZ9 |
| 0.94% | ILMN | ILLUMINA INC | -- | $862,343.16 | 7,154 | 2613990 |
| 0.94% | VTRS | VIATRIS INC | -- | $860,151.60 | 53,928 | BMWS3X9 |
| 0.74% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $675,481.25 | 2,875 | BV9G6B8 |
| 0.70% | IONS | IONIS PHARMACEUTICALS INC | -- | $641,606.40 | 7,584 | BDJ0LS6 |
| 0.67% | BBIO | BRIDGEBIO PHARMA INC | -- | $612,684.02 | 9,022 | BK1KWG8 |
| 0.65% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $599,277.84 | 4,668 | 2623911 |
| 0.64% | MEDP | MEDPACE HOLDINGS INC | -- | $586,902.24 | 1,319 | BDCBC61 |
| 0.64% | SNY | SANOFI-ADR | -- | $585,055.80 | 12,390 | 2964557 |
| 0.62% | GH | GUARDANT HEALTH INC | -- | $571,996.36 | 6,058 | BFXC911 |
| 0.62% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $565,965.40 | 8,995 | 2437071 |
| 0.61% | SMMT | SUMMIT THERAPEUTICS INC | -- | $560,833.04 | 34,856 | BMTVQS7 |
| 0.60% | EXEL | EXELIXIS INC | -- | $552,501.54 | 12,554 | 2576941 |
| 0.59% | ONC | BEONE MEDICINES LTD-ADR | -- | $546,323.36 | 1,474 | BYYWPW6 |
| 0.57% | BNTX | BIONTECH SE-ADR | -- | $520,408.62 | 4,734 | BK6H543 |
| 0.56% | RNA | AVIDITY BIOSCIENCES INC | -- | $514,450.60 | 7,055 | BMWHPY1 |
| 0.54% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $492,896.25 | 2,845 | B4Q5ZN4 |
| 0.51% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $465,370.77 | 1,063 | BD59BS7 |
| 0.50% | TEM | TEMPUS AI INC-CL A | -- | $463,705.26 | 8,094 | BSLSJJ0 |
| 0.49% | IBRX | IMMUNITYBIO INC | -- | $453,339.94 | 46,118 | BNSP0B8 |
| 0.45% | AXSM | AXSOME THERAPEUTICS INC | -- | $412,433.60 | 2,360 | BYZR4X4 |
| 0.44% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $401,507.26 | 6,359 | BYQBFJ8 |
| 0.44% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $401,020.66 | 1,171 | BQ721R4 |
| 0.43% | CYTK | CYTOKINETICS INC | -- | $390,788.50 | 5,725 | BBBSBJ5 |
| 0.42% | HALO | HALOZYME THERAPEUTICS INC | -- | $388,943.84 | 5,506 | 2975098 |
| 0.41% | KRYS | KRYSTAL BIOTECH INC | -- | $372,893.22 | 1,358 | BD6JX35 |
| 0.40% | PCVX | VAXCYTE INC | -- | $369,333.54 | 6,129 | BKPVGH6 |
| 0.40% | ABVX | ABIVAX SA-ADR | -- | $367,363.24 | 2,764 | BLC89B2 |
| 0.38% | NUVL | NUVALENT INC-A | -- | $348,346.00 | 3,382 | BMVBZD3 |
| 0.34% | ACLX | ARCELLX INC | -- | $307,921.25 | 2,707 | BPCJ1Q2 |
| 0.33% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $301,093.75 | 3,125 | BF2YWG4 |
| 0.32% | KYMR | KYMERA THERAPEUTICS INC | -- | $297,920.67 | 3,369 | BMPRZV5 |
| 0.29% | COGT | COGENT BIOSCIENCES INC | -- | $266,350.22 | 7,187 | BLR6XK8 |
| 0.29% | PTCT | PTC THERAPEUTICS INC | -- | $265,009.50 | 3,759 | B17VCN9 |
| 0.28% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $254,771.34 | 2,406 | BJDX8Y8 |
| 0.28% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $253,448.93 | 2,927 | BDCBCD8 |
| 0.27% | ALKS | ALKERMES PLC | -- | $248,860.89 | 7,731 | B3P6D26 |
| 0.26% | CRSP | CRISPR THERAPEUTICS AG | -- | $240,858.76 | 4,462 | BDHF4K6 |
| 0.25% | CAI | CARIS LIFE SCIENCES INC | -- | $233,042.04 | 13,211 | BT18HP9 |
| 0.24% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $224,519.76 | 4,776 | BFZQ0L8 |
| 0.24% | IMVT | IMMUNOVANT INC | -- | $223,230.40 | 8,207 | BJRFSB7 |
| 0.24% | CGON | CG ONCOLOGY INC | -- | $220,236.87 | 3,777 | BRBCSP4 |
| 0.23% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $212,247.98 | 14,719 | BFNF1D6 |
| 0.23% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $210,018.48 | 3,129 | BQS9486 |
| 0.23% | FOLD | AMICUS THERAPEUTICS INC | -- | $207,444.56 | 14,446 | B19FQ48 |
| 0.21% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $195,886.33 | 7,921 | 2713317 |
| 0.21% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $194,558.97 | 4,443 | BDD19F8 |
| 0.21% | INDV | INDIVIOR PHARMACEUTICALS INC | -- | $192,442.92 | 5,844 | BTZRLN8 |
| -- | -- | NEWAMSTERDAM PHARMA CO NV | -- | $192,026.53 | 5,309 | BP8JSP4 |
| 0.20% | ADMA | ADMA BIOLOGICS INC | -- | $181,535.76 | 11,144 | B9NSBM2 |
| 0.20% | APGE | APOGEE THERAPEUTICS INC | -- | $179,458.97 | 2,567 | BM9HHL5 |
| 0.19% | ERAS | ERASCA INC | -- | $172,957.68 | 13,284 | BNLYBF3 |
| 0.19% | TERN | TERNS PHARMACEUTICALS INC | -- | $172,347.48 | 4,218 | BMDJ0C9 |
| 0.18% | LGND | LIGAND PHARMACEUTICALS | -- | $169,325.30 | 922 | 2501578 |
| 0.17% | SYRE | SPYRE THERAPEUTICS INC | -- | $160,505.94 | 3,633 | BQBBDY8 |
| 0.17% | XENE | XENON PHARMACEUTICALS INC | -- | $154,560.96 | 3,618 | BRJ3GY4 |
| 0.16% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $150,887.85 | 5,735 | BKX9VD3 |
| 0.16% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $149,156.13 | 4,957 | BKY5JZ8 |
| 0.16% | DNLI | DENALI THERAPEUTICS INC | -- | $143,245.62 | 6,867 | BD2B4V0 |
| 0.15% | TARS | TARSUS PHARMACEUTICALS INC | -- | $138,344.92 | 1,988 | BMH5RL1 |
| 0.15% | TWST | TWIST BIOSCIENCE CORP | -- | $137,681.67 | 2,863 | BGKG6G7 |
| 0.15% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $136,102.65 | 2,685 | B72ZBG4 |
| 0.15% | BEAM | BEAM THERAPEUTICS INC | -- | $134,595.83 | 4,751 | BK6L288 |
| 0.14% | APLS | APELLIS PHARMACEUTICALS INC | -- | $133,044.87 | 5,921 | BYTQ6X1 |
| 0.14% | VCYT | VERACYTE INC | -- | $132,310.75 | 3,701 | BFTWZY0 |
| 0.14% | IDYA | IDEAYA BIOSCIENCES INC | -- | $131,811.55 | 4,105 | BK0VHF6 |
| 0.14% | TVTX | TRAVERE THERAPEUTICS INC | -- | $128,727.97 | 4,189 | BLFGJD5 |
| 0.14% | ALMS | ALUMIS INC | -- | $125,862.80 | 4,552 | BPLQG36 |
| 0.14% | VERA | VERA THERAPEUTICS INC | -- | $125,801.46 | 2,991 | BL55460 |
| 0.13% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $115,138.33 | 4,517 | BLB0YQ9 |
| 0.12% | IRON | DISC MEDICINE INC | -- | $113,152.00 | 1,768 | BMGJZJ8 |
| 0.12% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $110,007.72 | 7,148 | BJ5FZ74 |
| 0.12% | MLYS | MINERALYS THERAPEUTICS INC | -- | $107,185.65 | 3,705 | BP9N0G0 |
| 0.12% | WVE | WAVE LIFE SCIENCES LTD | -- | $105,718.50 | 7,831 | BYZG9R0 |
| 0.11% | DYN | DYNE THERAPEUTICS INC | -- | $103,314.15 | 6,687 | BN15WD1 |
| 0.11% | TXG | 10X GENOMICS INC-CLASS A | -- | $103,026.06 | 5,454 | BKS3RS7 |
| 0.11% | MAZE | MAZE THERAPEUTICS INC | -- | $102,601.62 | 2,253 | BSRK699 |
| 0.11% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $101,677.67 | 4,517 | BJ62Z18 |
| 0.11% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $100,229.85 | 2,115 | BRXB0C0 |
| 0.11% | STOK | STOKE THERAPEUTICS INC | -- | $96,915.25 | 2,675 | BJQ05Z6 |
| 0.10% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $91,545.59 | 6,173 | BFWLC09 |
| 0.10% | VCEL | VERICEL CORP | -- | $90,576.00 | 2,368 | BSBMN89 |
| 0.10% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $89,717.88 | 3,683 | BMZ4LN0 |
| 0.10% | HROW | HARROW INC | -- | $89,387.70 | 1,734 | BHNDW86 |
| 0.10% | SRPT | SAREPTA THERAPEUTICS INC | -- | $88,896.72 | 4,906 | B8DPDT7 |
| 0.09% | OCUL | OCULAR THERAPEUTIX INC | -- | $83,889.75 | 9,975 | BNZB1X8 |
| 0.09% | TYRA | TYRA BIOSCIENCES INC | -- | $83,216.70 | 2,499 | BMVNDH9 |
| 0.09% | PHVS | PHARVARIS NV | -- | $82,952.34 | 2,999 | BMZ2X38 |
| 0.09% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $82,446.00 | 2,730 | BCBVTX1 |
| 0.09% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $82,095.75 | 24,075 | BM9FJ13 |
| 0.09% | INVA | INNOVIVA INC | -- | $81,958.41 | 3,501 | BDDXF67 |
| 0.09% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $80,993.00 | 4,070 | BN7Q7R7 |
| 0.09% | ZYME | ZYMEWORKS INC | -- | $80,556.96 | 3,504 | BPCQZY9 |
| 0.09% | TNGX | TANGO THERAPEUTICS INC | -- | $80,275.38 | 6,306 | BP2P6L0 |
| 0.09% | GMAB | GENMAB A/S -SP ADR | -- | $80,111.99 | 2,737 | BBC9WC7 |
| 0.09% | MNKD | MANNKIND CORP | -- | $80,085.46 | 14,378 | BF081J4 |
| 0.09% | ANIP | ANI PHARMACEUTICALS INC | -- | $79,005.20 | 1,052 | BCDWBX6 |
| 0.09% | GRAL | GRAIL INC | -- | $78,529.75 | 1,825 | BSLSSX7 |
| 0.09% | DFTX | DEFINIUM THERAPEUTICS INC | -- | $78,173.40 | 4,612 | BV2DHY6 |
| 0.08% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $77,854.50 | 3,942 | BMX9K07 |
| 0.08% | MBX | MBX BIOSCIENCES INC | -- | $77,248.50 | 2,102 | BQXJKH2 |
| 0.08% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $76,283.55 | 2,779 | BMFD115 |
| 0.08% | ORKA | ORUKA THERAPEUTICS INC | -- | $75,536.44 | 2,267 | BKVF0J2 |
| 0.08% | SION | SIONNA THERAPEUTICS INC | -- | $75,449.00 | 2,090 | BQKXDX4 |
| 0.08% | RAPT | RAPT THERAPEUTICS INC | -- | $75,135.21 | 1,297 | BTJZB49 |
| 0.08% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $74,723.64 | 9,858 | 2100362 |
| 0.08% | NRIX | NURIX THERAPEUTICS INC | -- | $72,993.48 | 4,746 | BMVLGP2 |
| 0.08% | RLAY | RELAY THERAPEUTICS INC | -- | $72,548.10 | 8,115 | BN2R582 |
| 0.08% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $72,468.39 | 2,697 | BKSGZN7 |
| 0.08% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $71,473.80 | 5,142 | BPCK358 |
| 0.08% | NTLA | INTELLIA THERAPEUTICS INC | -- | $71,366.68 | 5,423 | BYZM6C2 |
| 0.08% | QURE | UNIQURE NV | -- | $71,364.41 | 2,917 | BJFSR88 |
| 0.08% | NVAX | NOVAVAX INC | -- | $71,220.24 | 7,609 | BJDQXG4 |
| 0.08% | ANAB | ANAPTYSBIO INC | -- | $70,359.84 | 1,296 | BDRW1L7 |
| 0.07% | PGEN | PRECIGEN INC | -- | $67,593.36 | 16,567 | BKM5C84 |
| 0.07% | ATAI | ATAIBECKLEY INC | -- | $67,509.85 | 17,005 | BWJDYK1 |
| 0.07% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $67,275.99 | 2,043 | BLCD809 |
| 0.07% | RAPP | RAPPORT THERAPEUTICS INC | -- | $67,227.84 | 2,232 | BR3T9B6 |
| 0.07% | TRVI | TREVI THERAPEUTICS INC | -- | $66,644.40 | 6,004 | BJH9ZN0 |
| 0.07% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $66,378.00 | 1,480 | BX7RSN3 |
| 0.07% | KOD | KODIAK SCIENCES INC | -- | $66,273.12 | 2,484 | BFXC933 |
| 0.07% | EYPT | EYEPOINT INC | -- | $66,163.32 | 3,876 | BMGS7L1 |
| 0.07% | ZBIO | ZENAS BIOPHARMA INC | -- | $65,689.82 | 2,513 | BQB42H3 |
| 0.07% | ARDX | ARDELYX INC | -- | $65,417.75 | 11,377 | BN89V40 |
| 0.07% | TSHA | TAYSHA GENE THERAPIES INC | -- | $62,073.00 | 12,825 | BNC1BX1 |
| 0.07% | ALVO | ALVOTECH SA | -- | $61,848.32 | 14,656 | BPNTJ34 |
| 0.07% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $60,183.37 | 3,497 | BYP80F1 |
| 0.06% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $59,485.99 | 3,049 | BP7KZP7 |
| 0.06% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $59,287.60 | 2,152 | BNFWZS4 |
| 0.06% | SEPN | SEPTERNA INC | -- | $58,688.00 | 2,096 | BQNKXX2 |
| 0.06% | NVCR | NOVOCURE LTD | -- | $57,568.14 | 5,243 | BYSS4X4 |
| 0.06% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $56,241.90 | 4,807 | BLB0YH0 |
| 0.06% | SVRA | SAVARA INC | -- | $54,303.90 | 9,527 | BYXGN81 |
| 0.06% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $53,716.43 | 18,587 | BF0DMK7 |
| 0.06% | ORIC | ORIC PHARMACEUTICALS INC | -- | $53,397.60 | 4,560 | BKVDFF7 |
| 0.06% | GERN | GERON CORP | -- | $52,903.53 | 29,889 | 2370381 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $52,157.79 | 681 | BNSP8K3 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $51,807.84 | 5,712 | B8K7T65 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $51,120.02 | 7,769 | BLR7H87 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $50,761.04 | 12,472 | BMFJJ97 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $49,407.68 | 959 | BL95N25 |
| 0.05% | VIR | VIR BIOTECHNOLOGY INC | -- | $48,399.02 | 6,514 | BK4PZ38 |
| 0.05% | FTRE | FORTREA HOLDINGS INC | -- | $46,893.84 | 4,326 | BRXYZ57 |
| 0.05% | VTYX | VENTYX BIOSCIENCES INC | -- | $46,606.95 | 3,341 | BMG99Y1 |
| 0.05% | PCRX | PACIRA BIOSCIENCES INC | -- | $46,543.54 | 2,014 | B3X26D8 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $45,856.64 | 2,192 | BZ7PJQ1 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $45,703.98 | 2,373 | BMNDK09 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $45,386.84 | 1,933 | BMGTLY5 |
| 0.05% | GHRS | GH RESEARCH PLC | -- | $44,779.68 | 2,904 | BP6C0S2 |
| 0.05% | CTMX | CYTOMX THERAPEUTICS INC | -- | $44,266.14 | 7,933 | BYWVTY5 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $42,623.88 | 4,628 | BMCR7V2 |
| 0.05% | ABCL | ABCELLERA BIOLOGICS INC | -- | $42,465.45 | 14,015 | BL53SR3 |
| 0.05% | BCAX | BICARA THERAPEUTICS INC | -- | $42,066.00 | 2,565 | BQB42F1 |
| 0.04% | CSTL | CASTLE BIOSCIENCES INC | -- | $39,560.98 | 1,367 | BKLCWZ3 |
| 0.04% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $39,531.95 | 9,005 | BZ0QMB7 |
| 0.04% | CGEM | CULLINAN THERAPEUTICS INC | -- | $38,696.34 | 2,766 | BM90J52 |
| 0.04% | XNCR | XENCOR INC | -- | $38,690.08 | 3,344 | BGCYWN8 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $38,297.28 | 2,296 | BQS7491 |
| 0.04% | OMER | OMEROS CORP | -- | $37,980.80 | 3,320 | B4NB858 |
| 0.04% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $37,873.47 | 3,331 | BJLKVS6 |
| 0.04% | JANX | JANUX THERAPEUTICS INC | -- | $37,649.92 | 2,816 | BMFX8Y7 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $37,384.62 | 11,193 | BBNBTD2 |
| 0.04% | ARVN | ARVINAS INC | -- | $36,986.10 | 3,007 | BDZ30Q0 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $36,830.52 | 2,367 | BD06CS0 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $36,146.76 | 1,833 | BD9GVY0 |
| 0.04% | BIOA | BIOAGE LABS INC | -- | $35,846.65 | 1,679 | BT9K6D8 |
| 0.04% | CMPS | COMPASS PATHWAYS PLC | -- | $34,634.20 | 4,412 | BMC3HS7 |
| 0.04% | PSNL | PERSONALIS INC | -- | $34,469.82 | 4,158 | BJQ0608 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $34,017.90 | 4,074 | BYZD465 |
| 0.04% | ANNX | ANNEXON INC | -- | $33,139.53 | 6,777 | BMVV9R5 |
| 0.03% | REPL | REPLIMUNE GROUP INC | -- | $30,816.47 | 3,673 | BDDVW37 |
| 0.03% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $29,121.00 | 850 | BQD3J33 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $28,563.75 | 7,617 | B3MZ6K5 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $28,418.26 | 3,769 | BFYQFJ2 |
| 0.03% | PRME | PRIME MEDICINE INC | -- | $28,229.68 | 8,452 | BPBJFM7 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $27,603.45 | 2,667 | BMFK3H6 |
| 0.03% | FULC | FULCRUM THERAPEUTICS INC | -- | $27,595.26 | 2,534 | BJDX8Z9 |
| 0.03% | NMRA | NEUMORA THERAPEUTICS INC | -- | $26,989.35 | 7,823 | BN4JN37 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $25,894.00 | 2,675 | BKLXFX5 |
| 0.03% | CRMD | CORMEDIX INC | -- | $25,859.89 | 3,689 | BJ0LT31 |
| 0.03% | KMDA | KAMADA LTD | -- | $23,984.88 | 2,701 | B2Q9833 |
| 0.02% | ETON | ETON PHARMACEUTICALS INC | -- | $22,959.68 | 1,256 | BGL0JK3 |
| 0.02% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $22,933.20 | 2,636 | BLFBZ32 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $22,929.99 | 677 | B292NQ7 |
| 0.02% | PRTA | PROTHENA CORP PLC | -- | $22,856.40 | 2,520 | B91XRN2 |
| 0.02% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $22,676.64 | 5,712 | BYVQJ96 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $22,551.05 | 2,767 | B12W3P6 |
| 0.02% | LYEL | LYELL IMMUNOPHARMA INC | -- | $22,551.03 | 993 | BTNMG41 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $22,498.63 | 3,353 | 2107437 |
| 0.02% | KROS | KEROS THERAPEUTICS INC | -- | $22,402.46 | 1,426 | BM7V485 |
| 0.02% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $22,334.88 | 14,136 | B4N8MH9 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $22,084.72 | 4,886 | BFY7DC4 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $21,885.76 | 10,522 | BFZNYB7 |
| 0.02% | LXEO | LEXEO THERAPEUTICS INC | -- | $21,697.95 | 3,417 | BQ6C357 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $21,413.76 | 3,648 | BQHN6C7 |
| 0.02% | IVVD | INVIVYD INC | -- | $20,889.75 | 12,975 | BM8NHS1 |
| 0.02% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $20,777.40 | 6,790 | BMCWKZ2 |
| 0.02% | PEPG | PEPGEN INC | -- | $20,408.46 | 3,219 | BMTX3D7 |
| 0.02% | UPB | UPSTREAM BIO INC | -- | $20,290.60 | 2,530 | BRCFFK6 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $20,209.10 | 1,790 | BP81RK8 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $20,189.40 | 5,060 | BDFKQ07 |
| 0.02% | RGNX | REGENXBIO INC | -- | $18,817.80 | 2,370 | BZ0G875 |
| 0.02% | ABSI | ABSCI CORP | -- | $18,658.65 | 7,041 | BN94K69 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $18,562.44 | 876 | BPBPCG8 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $18,224.99 | 1,351 | B9L5200 |
| 0.02% | LENZ | LENZ THERAPEUTICS INC | -- | $17,418.85 | 1,465 | BQV0J03 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $17,401.28 | 4,183 | BYTYP72 |
| 0.02% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $16,922.48 | 1,082 | BPRBTY7 |
| 0.02% | AVIR | ATEA PHARMACEUTICALS INC | -- | $16,790.22 | 3,658 | BLN9Z50 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $16,772.49 | 2,359 | B7F2TY6 |
| 0.02% | ACRS | ACLARIS THERAPEUTICS INC | -- | $16,487.25 | 5,073 | BYV2W40 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $16,292.04 | 2,973 | BP81R42 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $16,248.16 | 9,392 | BFMLGR4 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $16,223.41 | 2,051 | BSMLR16 |
| 0.02% | NBP | NOVABRIDGE BIOSCIENCES | -- | $15,626.28 | 4,868 | BKRRKY7 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $15,226.00 | 2,648 | BMF7DT9 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $14,994.08 | 3,023 | BMVBZF5 |
| 0.01% | NGNE | NEUROGENE INC | -- | $13,405.25 | 725 | BS2F741 |
| 0.01% | EOLS | EVOLUS INC | -- | $13,141.55 | 3,035 | BDRJH21 |
| 0.01% | CABA | CABALETTA BIO INC | -- | $13,070.30 | 4,507 | BK5MWR1 |
| 0.01% | AARD | AARDVARK THERAPEUTICS INC | -- | $12,819.02 | 1,019 | BTXQTX3 |
| 0.01% | LFCR | LIFECORE BIOMEDICAL INC | -- | $12,786.66 | 1,754 | 2517058 |
| 0.01% | CADL | CANDEL THERAPEUTICS INC | -- | $12,772.90 | 2,570 | BP0TQC5 |
| 0.01% | VOR | VOR BIOPHARMA INC | -- | $12,166.38 | 789 | BRJJYT3 |
| 0.01% | ACIU | AC IMMUNE SA | -- | $11,893.53 | 4,701 | BZC0D70 |
| 0.01% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $11,783.04 | 2,166 | BKDQKM6 |
| 0.01% | OABI | OMNIAB INC | -- | $11,525.40 | 6,740 | BN13S71 |
| 0.01% | LRMR | LARIMAR THERAPEUTICS INC | -- | $11,262.48 | 4,008 | BMXNGZ6 |
| 0.01% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $11,082.96 | 2,199 | BL5B6Z1 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $10,655.32 | 2,644 | BPRB2N7 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $10,437.40 | 4,538 | BKX9NQ0 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $10,201.10 | 1,330 | BKC9SX3 |
| 0.01% | HUMA | HUMACYTE INC | -- | $9,995.52 | 8,768 | BMYTJP4 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $9,877.22 | 2,759 | BY7RB53 |
| 0.01% | MENS | JYONG BIOTECH LTD | -- | $9,718.80 | 3,560 | BPTK6Z2 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $9,167.58 | 5,659 | BRK0149 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $8,639.19 | 4,571 | BZ8FPH3 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $8,401.92 | 4,376 | BNYJR68 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $8,349.36 | 9,156 | BNR5QT9 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $7,666.56 | 1,452 | BP2NYN2 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $6,429.88 | 2,668 | BKTV702 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $5,845.76 | 4,567 | BNNXX18 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $5,162.36 | 2,506 | BP7L561 |
| -- | GOSS | GOSSAMER BIO INC | -- | $4,587.30 | 10,837 | BJ0CK86 |
| -- | TNYA | TENAYA THERAPEUTICS INC | -- | $4,575.47 | 7,796 | BNNXX52 |
| -- | CDXS | CODEXIS INC | -- | $4,525.03 | 4,229 | B5LL2C2 |
| -- | PYXS | PYXIS ONCOLOGY INC | -- | $4,226.75 | 2,915 | BLBR8D5 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $18.40 | 01 | BTFHQP5 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| -- | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 38,015,063 | -- | 6,321 | -- |
| -- | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 26,552,207 | -- | 4,415 | -- |
| -- | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 20,814,765 | -- | 3,461 | -- |
| -- | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 15,871,184 | -- | 2,639 | -- |
| -- | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,939,000 | -- | 2,484 | -- |
| -- | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,806,919 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $28,886,103.72 | 28,886,104 | -- |
Index
as of 12/31/2025
- Total Number of Companies262
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$7.32 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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