BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 12/31/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 2/04/2026- NAV $85.27
- NAV Change $+0.40
- Market Price $85.24
- Market Price Change $+0.43
- Trading Volume (M) 5,527
- 30-Day Median Bid Ask Spread 0.28%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 2/04/2026- NAV $85.27
- NAV Change $+0.40
- Market Price $85.24
- Market Price Change $+0.43
- Trading Volume (M) 5,527
- 30-Day Median Bid Ask Spread 0.28%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 12/31/2025
Holdings
as of 2/04/2026
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 6.61% | GILD | GILEAD SCIENCES INC | -- | $5,916,904.49 | 40,463 | 2369174 |
| 6.17% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,525,316.36 | 11,743 | 2931034 |
| 6.03% | AMGN | AMGEN INC | -- | $5,397,421.80 | 14,739 | 2023607 |
| 4.19% | REGN | REGENERON PHARMACEUTICALS | -- | $3,748,190.16 | 4,836 | 2730190 |
| 2.43% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,177,224.56 | 6,186 | B00FWN1 |
| 1.70% | INSM | INSMED INC | -- | $1,522,265.84 | 9,986 | 2614487 |
| 1.42% | BIIB | BIOGEN INC | -- | $1,273,856.05 | 6,869 | 2455965 |
| 1.30% | ARGX | ARGENX SE - ADR | -- | $1,159,735.81 | 1,363 | BDVLM39 |
| 1.09% | UTHR | UNITED THERAPEUTICS CORP | -- | $972,901.44 | 2,016 | 2430412 |
| 1.07% | ILMN | ILLUMINA INC | -- | $959,995.26 | 7,154 | 2613990 |
| 1.05% | INCY | INCYTE CORP | -- | $943,099.20 | 9,192 | 2471950 |
| 0.98% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $873,818.40 | 20,005 | BMVP7Y0 |
| 0.98% | RVMD | REVOLUTION MEDICINES INC | -- | $873,608.52 | 9,052 | BL71K91 |
| 0.87% | MRNA | MODERNA INC | -- | $782,348.84 | 18,292 | BGSXTS3 |
| 0.86% | VTRS | VIATRIS INC | -- | $774,406.08 | 53,928 | BMWS3X9 |
| 0.83% | MEDP | MEDPACE HOLDINGS INC | -- | $740,644.88 | 1,319 | BDCBC61 |
| 0.79% | ROIV | ROIVANT SCIENCES LTD | -- | $705,010.60 | 32,564 | BMW4NZ9 |
| 0.76% | BBIO | BRIDGEBIO PHARMA INC | -- | $678,364.18 | 9,022 | BK1KWG8 |
| 0.72% | IONS | IONIS PHARMACEUTICALS INC | -- | $644,564.16 | 7,584 | BDJ0LS6 |
| 0.72% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $643,530.48 | 4,668 | 2623911 |
| 0.72% | GH | GUARDANT HEALTH INC | -- | $643,056.70 | 6,058 | BFXC911 |
| 0.71% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $631,723.75 | 2,875 | BV9G6B8 |
| 0.67% | SNY | SANOFI-ADR | -- | $595,711.20 | 12,390 | 2964557 |
| 0.60% | EXEL | EXELIXIS INC | -- | $535,428.10 | 12,554 | 2576941 |
| 0.58% | ONC | BEONE MEDICINES LTD-ADR | -- | $518,848.00 | 1,474 | BYYWPW6 |
| 0.58% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $518,291.90 | 8,995 | 2437071 |
| 0.58% | BNTX | BIONTECH SE-ADR | -- | $514,917.18 | 4,734 | BK6H543 |
| 0.57% | RNA | AVIDITY BIOSCIENCES INC | -- | $513,039.60 | 7,055 | BMWHPY1 |
| 0.57% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $508,762.43 | 1,063 | BD59BS7 |
| 0.56% | SMMT | SUMMIT THERAPEUTICS INC | -- | $502,623.52 | 34,856 | BMTVQS7 |
| 0.53% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $471,473.40 | 2,845 | B4Q5ZN4 |
| 0.49% | AXSM | AXSOME THERAPEUTICS INC | -- | $437,874.40 | 2,360 | BYZR4X4 |
| 0.48% | TEM | TEMPUS AI INC | -- | $433,433.70 | 8,094 | BSLSJJ0 |
| 0.48% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $432,793.54 | 6,359 | BYQBFJ8 |
| 0.48% | HALO | HALOZYME THERAPEUTICS INC | -- | $429,082.58 | 5,506 | 2975098 |
| 0.41% | KRYS | KRYSTAL BIOTECH INC | -- | $365,478.54 | 1,358 | BD6JX35 |
| 0.41% | CYTK | CYTOKINETICS INC | -- | $363,652.00 | 5,725 | BBBSBJ5 |
| 0.40% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $355,211.14 | 1,171 | BQ721R4 |
| 0.40% | NUVL | NUVALENT INC-A | -- | $355,076.18 | 3,382 | BMVBZD3 |
| 0.38% | PCVX | VAXCYTE INC | -- | $338,811.12 | 6,129 | BKPVGH6 |
| 0.38% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $337,406.25 | 3,125 | BF2YWG4 |
| 0.35% | ABVX | ABIVAX SA-ADR | -- | $313,907.48 | 2,764 | BLC89B2 |
| 0.32% | CAI | CARIS LIFE SCIENCES INC | -- | $288,528.24 | 13,211 | BT18HP9 |
| 0.31% | PTCT | PTC THERAPEUTICS INC | -- | $277,827.69 | 3,759 | B17VCN9 |
| 0.30% | IBRX | IMMUNITYBIO INC | -- | $271,173.84 | 46,118 | BNSP0B8 |
| 0.30% | COGT | COGENT BIOSCIENCES INC | -- | $264,840.95 | 7,187 | BLR6XK8 |
| 0.29% | ALKS | ALKERMES PLC | -- | $263,859.03 | 7,731 | B3P6D26 |
| 0.29% | KYMR | KYMERA THERAPEUTICS INC | -- | $261,771.30 | 3,369 | BMPRZV5 |
| 0.28% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $254,262.54 | 3,129 | BQS9486 |
| 0.28% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $250,127.76 | 2,406 | BJDX8Y8 |
| 0.27% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $243,819.10 | 2,927 | BDCBCD8 |
| 0.25% | CRSP | CRISPR THERAPEUTICS AG | -- | $223,858.54 | 4,462 | BDHF4K6 |
| 0.25% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $223,660.08 | 4,776 | BFZQ0L8 |
| 0.24% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $212,395.17 | 14,719 | BFNF1D6 |
| 0.24% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $210,731.49 | 4,443 | BDD19F8 |
| 0.23% | IMVT | IMMUNOVANT INC | -- | $206,406.05 | 8,207 | BJRFSB7 |
| 0.23% | FOLD | AMICUS THERAPEUTICS INC | -- | $206,144.42 | 14,446 | B19FQ48 |
| 0.22% | INDV | INDIVIOR PHARMACEUTICALS INC | -- | $200,682.96 | 5,844 | BTZRLN8 |
| 0.22% | CGON | CG ONCOLOGY INC | -- | $196,328.46 | 3,777 | BRBCSP4 |
| 0.21% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $191,925.83 | 7,921 | 2713317 |
| 0.21% | ACLX | ARCELLX INC | -- | $187,811.66 | 2,707 | BPCJ1Q2 |
| 0.21% | ADMA | ADMA BIOLOGICS INC | -- | $183,764.56 | 11,144 | B9NSBM2 |
| 0.20% | LGND | LIGAND PHARMACEUTICALS | -- | $182,860.26 | 922 | 2501578 |
| 0.20% | GRAL | GRAIL INC | -- | $180,456.00 | 1,825 | BSLSSX7 |
| 0.20% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $175,090.82 | 5,309 | BP8JSP4 |
| 0.19% | APGE | APOGEE THERAPEUTICS INC | -- | $166,546.96 | 2,567 | BM9HHL5 |
| 0.17% | TERN | TERNS PHARMACEUTICALS INC | -- | $152,101.08 | 4,218 | BMDJ0C9 |
| 0.17% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $149,568.80 | 5,735 | BKX9VD3 |
| 0.17% | ERAS | ERASCA INC | -- | $149,312.16 | 13,284 | BNLYBF3 |
| 0.17% | XENE | XENON PHARMACEUTICALS INC | -- | $148,880.70 | 3,618 | BRJ3GY4 |
| 0.16% | DNLI | DENALI THERAPEUTICS INC | -- | $146,129.76 | 6,867 | BD2B4V0 |
| 0.16% | IRON | DISC MEDICINE INC | -- | $144,357.20 | 1,768 | BMGJZJ8 |
| 0.16% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $141,125.79 | 4,957 | BKY5JZ8 |
| 0.15% | TWST | TWIST BIOSCIENCE CORP | -- | $137,767.56 | 2,863 | BGKG6G7 |
| 0.15% | APLS | APELLIS PHARMACEUTICALS INC | -- | $137,071.15 | 5,921 | BYTQ6X1 |
| 0.15% | IDYA | IDEAYA BIOSCIENCES INC | -- | $136,614.40 | 4,105 | BK0VHF6 |
| 0.15% | VCYT | VERACYTE INC | -- | $133,606.10 | 3,701 | BFTWZY0 |
| 0.15% | TVTX | TRAVERE THERAPEUTICS INC | -- | $132,707.52 | 4,189 | BLFGJD5 |
| 0.15% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $131,779.80 | 2,685 | B72ZBG4 |
| 0.14% | BEAM | BEAM THERAPEUTICS INC | -- | $128,039.45 | 4,751 | BK6L288 |
| 0.14% | VERA | VERA THERAPEUTICS INC | -- | $127,835.34 | 2,991 | BL55460 |
| 0.14% | TARS | TARSUS PHARMACEUTICALS INC | -- | $126,257.88 | 1,988 | BMH5RL1 |
| 0.14% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $123,660.40 | 7,148 | BJ5FZ74 |
| 0.14% | DYN | DYNE THERAPEUTICS INC | -- | $121,904.01 | 6,687 | BN15WD1 |
| 0.13% | ALMS | ALUMIS INC | -- | $119,945.20 | 4,552 | BPLQG36 |
| 0.13% | SYRE | SPYRE THERAPEUTICS INC | -- | $116,510.31 | 3,633 | BQBBDY8 |
| 0.13% | MLYS | MINERALYS THERAPEUTICS INC | -- | $113,447.10 | 3,705 | BP9N0G0 |
| 0.13% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $112,925.00 | 4,517 | BLB0YQ9 |
| 0.12% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $111,524.73 | 4,517 | BJ62Z18 |
| 0.12% | MAZE | MAZE THERAPEUTICS INC | -- | $108,459.42 | 2,253 | BSRK699 |
| 0.12% | WVE | WAVE LIFE SCIENCES LTD | -- | $104,387.23 | 7,831 | BYZG9R0 |
| 0.12% | TXG | 10X GENOMICS INC-CLASS A | -- | $103,953.24 | 5,454 | BKS3RS7 |
| 0.11% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $100,652.04 | 2,697 | BKSGZN7 |
| 0.11% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $97,010.22 | 3,683 | BMZ4LN0 |
| 0.11% | SRPT | SAREPTA THERAPEUTICS INC | -- | $96,795.38 | 4,906 | B8DPDT7 |
| 0.10% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $93,892.50 | 24,075 | BM9FJ13 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $92,044.80 | 2,115 | BRXB0C0 |
| 0.10% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $90,002.34 | 6,173 | BFWLC09 |
| 0.10% | VCEL | VERICEL CORP | -- | $87,331.84 | 2,368 | BSBMN89 |
| 0.10% | GMAB | GENMAB A/S -SP ADR | -- | $87,310.30 | 2,737 | BBC9WC7 |
| 0.10% | SION | SIONNA THERAPEUTICS INC | -- | $86,348.35 | 2,090 | BQKXDX4 |
| 0.10% | STOK | STOKE THERAPEUTICS INC | -- | $85,600.00 | 2,675 | BJQ05Z6 |
| 0.10% | ANIP | ANI PHARMACEUTICALS INC | -- | $85,496.04 | 1,052 | BCDWBX6 |
| 0.10% | OCUL | OCULAR THERAPEUTIX INC | -- | $85,286.25 | 9,975 | BNZB1X8 |
| 0.10% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $85,273.98 | 5,498 | BRJZSK0 |
| 0.09% | ARDX | ARDELYX INC | -- | $83,962.26 | 11,377 | BN89V40 |
| 0.09% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $83,150.10 | 4,070 | BN7Q7R7 |
| 0.09% | MNKD | MANNKIND CORP | -- | $83,104.84 | 14,378 | BF081J4 |
| 0.09% | HROW | HARROW INC | -- | $81,844.80 | 1,734 | BHNDW86 |
| 0.09% | ZYME | ZYMEWORKS INC | -- | $80,977.44 | 3,504 | BPCQZY9 |
| 0.09% | MBX | MBX BIOSCIENCES INC | -- | $80,653.74 | 2,102 | BQXJKH2 |
| 0.09% | PHVS | PHARVARIS NV | -- | $79,593.46 | 2,999 | BMZ2X38 |
| 0.09% | NRIX | NURIX THERAPEUTICS INC | -- | $78,546.30 | 4,746 | BMVLGP2 |
| 0.09% | DFTX | DEFINIUM THERAPEUTICS INC | -- | $78,542.36 | 4,612 | BV2DHY6 |
| 0.09% | QURE | UNIQURE NV | -- | $77,738.05 | 2,917 | BJFSR88 |
| 0.09% | TNGX | TANGO THERAPEUTICS INC | -- | $77,689.92 | 6,306 | BP2P6L0 |
| 0.09% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $77,311.78 | 2,779 | BMFD115 |
| 0.09% | TYRA | TYRA BIOSCIENCES INC | -- | $76,894.23 | 2,499 | BMVNDH9 |
| 0.08% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $75,621.00 | 2,730 | BCBVTX1 |
| 0.08% | PGEN | PRECIGEN INC | -- | $75,545.52 | 16,567 | BKM5C84 |
| 0.08% | INVA | INNOVIVA INC | -- | $75,201.48 | 3,501 | BDDXF67 |
| 0.08% | RAPT | RAPT THERAPEUTICS INC | -- | $74,940.66 | 1,297 | BTJZB49 |
| 0.08% | ORKA | ORUKA THERAPEUTICS INC | -- | $74,811.00 | 2,267 | BKVF0J2 |
| 0.08% | ALVO | ALVOTECH SA | -- | $74,599.04 | 14,656 | BPNTJ34 |
| 0.08% | UPB | UPSTREAM BIO INC | -- | $74,331.40 | 2,530 | BRCFFK6 |
| 0.08% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $72,807.54 | 3,497 | BYP80F1 |
| 0.08% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $71,370.96 | 5,142 | BPCK358 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $71,306.40 | 1,480 | BX7RSN3 |
| 0.08% | FTRE | FORTREA HOLDINGS INC | -- | $69,475.56 | 4,326 | BRXYZ57 |
| 0.08% | RLAY | RELAY THERAPEUTICS INC | -- | $68,896.35 | 8,115 | BN2R582 |
| 0.08% | TRVI | TREVI THERAPEUTICS INC | -- | $68,745.80 | 6,004 | BJH9ZN0 |
| 0.07% | NTLA | INTELLIA THERAPEUTICS INC | -- | $67,028.28 | 5,423 | BYZM6C2 |
| 0.07% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $65,634.30 | 3,942 | BMX9K07 |
| 0.07% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $64,354.50 | 2,043 | BLCD809 |
| 0.07% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $63,288.36 | 9,858 | 2100362 |
| 0.07% | NVAX | NOVAVAX INC | -- | $62,926.43 | 7,609 | BJDQXG4 |
| 0.07% | ANAB | ANAPTYSBIO INC | -- | $62,700.48 | 1,296 | BDRW1L7 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $61,568.72 | 2,152 | BNFWZS4 |
| 0.07% | ATAI | ATAIBECKLEY INC | -- | $61,388.05 | 17,005 | BWJDYK1 |
| 0.07% | NVCR | NOVOCURE LTD | -- | $60,609.08 | 5,243 | BYSS4X4 |
| 0.07% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $59,546.97 | 3,049 | BP7KZP7 |
| 0.07% | RAPP | RAPPORT THERAPEUTICS INC | -- | $59,002.92 | 2,232 | BR3T9B6 |
| 0.07% | TSHA | TAYSHA GENE THERAPIES INC | -- | $58,225.50 | 12,825 | BNC1BX1 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $56,223.36 | 681 | BNSP8K3 |
| 0.06% | KOD | KODIAK SCIENCES INC | -- | $55,591.92 | 2,484 | BFXC933 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $55,004.52 | 7,769 | BLR7H87 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $54,492.48 | 5,712 | B8K7T65 |
| 0.06% | SEPN | SEPTERNA INC | -- | $52,253.28 | 2,096 | BQNKXX2 |
| 0.06% | ZBIO | ZENAS BIOPHARMA INC | -- | $51,918.58 | 2,513 | BQB42H3 |
| 0.06% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $51,627.18 | 4,807 | BLB0YH0 |
| 0.06% | SVRA | SAVARA INC | -- | $51,064.72 | 9,527 | BYXGN81 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $50,761.04 | 12,472 | BMFJJ97 |
| 0.05% | VIR | VIR BIOTECHNOLOGY INC | -- | $48,855.00 | 6,514 | BK4PZ38 |
| 0.05% | ORIC | ORIC PHARMACEUTICALS INC | -- | $48,381.60 | 4,560 | BKVDFF7 |
| 0.05% | EYPT | EYEPOINT INC | -- | $47,791.08 | 3,876 | BMGS7L1 |
| 0.05% | CSTL | CASTLE BIOSCIENCES INC | -- | $47,790.32 | 1,367 | BKLCWZ3 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $47,673.57 | 2,373 | BMNDK09 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $46,927.92 | 4,628 | BMCR7V2 |
| 0.05% | VTYX | VENTYX BIOSCIENCES INC | -- | $46,473.31 | 3,341 | BMG99Y1 |
| 0.05% | ABCL | ABCELLERA BIOLOGICS INC | -- | $45,829.05 | 14,015 | BL53SR3 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $45,396.32 | 2,192 | BZ7PJQ1 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $45,352.28 | 18,587 | BF0DMK7 |
| 0.05% | GHRS | GH RESEARCH PLC | -- | $45,128.16 | 2,904 | BP6C0S2 |
| 0.05% | CTMX | CYTOMX THERAPEUTICS INC | -- | $44,980.11 | 7,933 | BYWVTY5 |
| 0.05% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $44,069.13 | 3,331 | BJLKVS6 |
| 0.05% | GERN | GERON CORP | -- | $43,936.83 | 29,889 | 2370381 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $42,583.99 | 1,933 | BMGTLY5 |
| 0.05% | BCAX | BICARA THERAPEUTICS INC | -- | $41,989.05 | 2,565 | BQB42F1 |
| 0.05% | PCRX | PACIRA BIOSCIENCES INC | -- | $41,649.52 | 2,014 | B3X26D8 |
| 0.05% | ANNX | ANNEXON INC | -- | $40,933.08 | 6,777 | BMVV9R5 |
| 0.04% | ARVN | ARVINAS INC | -- | $40,263.73 | 3,007 | BDZ30Q0 |
| 0.04% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $39,319.00 | 959 | BL95N25 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $39,009.04 | 2,296 | BQS7491 |
| 0.04% | XNCR | XENCOR INC | -- | $38,556.32 | 3,344 | BGCYWN8 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $38,280.06 | 11,193 | BBNBTD2 |
| 0.04% | OMER | OMEROS CORP | -- | $38,213.20 | 3,320 | B4NB858 |
| 0.04% | JANX | JANUX THERAPEUTICS INC | -- | $37,537.28 | 2,816 | BMFX8Y7 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $35,457.66 | 2,367 | BD06CS0 |
| 0.04% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $34,939.40 | 9,005 | BZ0QMB7 |
| 0.04% | PSNL | PERSONALIS INC | -- | $34,552.98 | 4,158 | BJQ0608 |
| 0.04% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $34,162.25 | 7,617 | B3MZ6K5 |
| 0.04% | CGEM | CULLINAN THERAPEUTICS INC | -- | $34,104.78 | 2,766 | BM90J52 |
| 0.04% | BIOA | BIOAGE LABS INC | -- | $33,831.85 | 1,679 | BT9K6D8 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $32,877.18 | 4,074 | BYZD465 |
| 0.03% | ZLAB | ZAI LAB LTD-ADR | -- | $31,161.00 | 1,833 | BD9GVY0 |
| 0.03% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $29,707.50 | 850 | BQD3J33 |
| 0.03% | PRME | PRIME MEDICINE INC | -- | $29,370.70 | 8,452 | BPBJFM7 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $29,322.82 | 3,769 | BFYQFJ2 |
| 0.03% | CRMD | CORMEDIX INC | -- | $28,921.76 | 3,689 | BJ0LT31 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $28,104.44 | 4,412 | BMC3HS7 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $27,565.20 | 14,136 | B4N8MH9 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $26,670.00 | 2,667 | BMFK3H6 |
| 0.03% | GOSS | GOSSAMER BIO INC | -- | $26,659.02 | 10,837 | BJ0CK86 |
| 0.03% | KROS | KEROS THERAPEUTICS INC | -- | $25,739.30 | 1,426 | BM7V485 |
| 0.03% | REPL | REPLIMUNE GROUP INC | -- | $25,711.00 | 3,673 | BDDVW37 |
| 0.03% | RGNX | REGENXBIO INC | -- | $25,477.50 | 2,370 | BZ0G875 |
| 0.03% | FULC | FULCRUM THERAPEUTICS INC | -- | $25,086.60 | 2,534 | BJDX8Z9 |
| 0.03% | ALT | ALTIMMUNE INC | -- | $25,065.18 | 4,886 | BFY7DC4 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $24,850.75 | 2,675 | BKLXFX5 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $24,841.59 | 3,417 | BQ6C357 |
| 0.03% | LYEL | LYELL IMMUNOPHARMA INC | -- | $24,010.74 | 993 | BTNMG41 |
| 0.03% | IVVD | INVIVYD INC | -- | $23,874.00 | 12,975 | BM8NHS1 |
| 0.03% | SLDB | SOLID BIOSCIENCES INC | -- | $23,784.96 | 3,648 | BQHN6C7 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $23,565.84 | 2,636 | BLFBZ32 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $23,444.51 | 677 | B292NQ7 |
| 0.03% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $22,848.00 | 5,712 | BYVQJ96 |
| 0.03% | SIGA | SIGA TECHNOLOGIES INC | -- | $22,565.69 | 3,353 | 2107437 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $22,402.80 | 2,520 | B91XRN2 |
| 0.02% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $22,203.30 | 6,790 | BMCWKZ2 |
| 0.02% | KMDA | KAMADA LTD | -- | $21,878.10 | 2,701 | B2Q9833 |
| 0.02% | LENZ | LENZ THERAPEUTICS INC | -- | $21,418.30 | 1,465 | BQV0J03 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $21,029.20 | 2,767 | B12W3P6 |
| 0.02% | ABSI | ABSCI CORP | -- | $20,489.31 | 7,041 | BN94K69 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $20,340.72 | 876 | BPBPCG8 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $19,367.80 | 1,790 | BP81RK8 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $18,939.60 | 10,522 | BFZNYB7 |
| 0.02% | ETON | ETON PHARMACEUTICALS INC | -- | $18,526.00 | 1,256 | BGL0JK3 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $18,211.48 | 1,351 | B9L5200 |
| 0.02% | ACRS | ACLARIS THERAPEUTICS INC | -- | $17,958.42 | 5,073 | BYV2W40 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $17,275.79 | 4,183 | BYTYP72 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $17,094.75 | 2,973 | BP81R42 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $16,849.80 | 5,060 | BDFKQ07 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $16,748.90 | 2,359 | B7F2TY6 |
| 0.02% | NBP | NOVABRIDGE BIOSCIENCES | -- | $16,648.56 | 4,868 | BKRRKY7 |
| 0.02% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $16,013.60 | 1,082 | BPRBTY7 |
| 0.02% | PEPG | PEPGEN INC | -- | $15,805.29 | 3,219 | BMTX3D7 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $15,802.46 | 7,823 | BN4JN37 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $15,628.62 | 2,051 | BSMLR16 |
| 0.02% | AVIR | ATEA PHARMACEUTICALS INC | -- | $14,997.80 | 3,658 | BLN9Z50 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $14,908.24 | 2,648 | BMF7DT9 |
| 0.02% | CADL | CANDEL THERAPEUTICS INC | -- | $14,674.70 | 2,570 | BP0TQC5 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $14,385.06 | 4,701 | BZC0D70 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $14,329.02 | 3,023 | BMVBZF5 |
| 0.02% | EOLS | EVOLUS INC | -- | $13,930.65 | 3,035 | BDRJH21 |
| 0.02% | LFCR | LIFECORE BIOMEDICAL INC | -- | $13,856.60 | 1,754 | 2517058 |
| 0.01% | LRMR | LARIMAR THERAPEUTICS INC | -- | $13,146.24 | 4,008 | BMXNGZ6 |
| 0.01% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $12,960.96 | 9,392 | BFMLGR4 |
| 0.01% | AARD | AARDVARK THERAPEUTICS INC | -- | $12,798.64 | 1,019 | BTXQTX3 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $12,562.98 | 5,659 | BRK0149 |
| 0.01% | NGNE | NEUROGENE INC | -- | $12,455.50 | 725 | BS2F741 |
| 0.01% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $12,389.52 | 2,166 | BKDQKM6 |
| 0.01% | OABI | OMNIAB INC | -- | $11,727.60 | 6,740 | BN13S71 |
| 0.01% | CABA | CABALETTA BIO INC | -- | $11,312.57 | 4,507 | BK5MWR1 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $10,318.66 | 2,759 | BY7RB53 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $10,047.20 | 2,644 | BPRB2N7 |
| 0.01% | VOR | VOR BIOPHARMA INC | -- | $9,783.60 | 789 | BRJJYT3 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $9,748.90 | 1,330 | BKC9SX3 |
| 0.01% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $9,455.70 | 2,199 | BL5B6Z1 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $9,430.68 | 9,156 | BNR5QT9 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $8,913.45 | 4,571 | BZ8FPH3 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $8,828.16 | 1,452 | BP2NYN2 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $8,576.82 | 4,538 | BKX9NQ0 |
| 0.01% | HUMA | HUMACYTE INC | -- | $8,401.50 | 8,768 | BMYTJP4 |
| 0.01% | MENS | JYONG BIOTECH LTD | -- | $7,476.00 | 3,560 | BPTK6Z2 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $7,089.12 | 4,376 | BNYJR68 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $6,565.01 | 7,796 | BNNXX52 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $6,376.52 | 2,668 | BKTV702 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $5,763.80 | 2,506 | BP7L561 |
| 0.01% | CDXS | CODEXIS INC | -- | $5,582.28 | 4,229 | B5LL2C2 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $5,434.73 | 4,567 | BNNXX18 |
| -- | PYXS | PYXIS ONCOLOGY INC | -- | $4,401.65 | 2,915 | BLBR8D5 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $14.89 | 01 | BTFHQP5 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 39.73% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 35,573,928 | -- | 6,001 | -- |
| 29.23% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 26,172,120 | -- | 4,415 | -- |
| 23.46% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 21,002,904 | -- | 3,543 | -- |
| 17.47% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 15,643,992 | -- | 2,639 | -- |
| 16.45% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,725,152 | -- | 2,484 | -- |
| 4.19% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,752,424 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $27,374,402.90 | 27,374,403 | -- |
Index
as of 12/31/2025
- Total Number of Companies262
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$7.32 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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