BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 11/30/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 16.90% | 51.72% | 95.62% | 66.67% | 42.59% | 11.36% | 1.61% | 2.01% | 16.86% | 04/07/2010 |
| BIB Market Price | 17.00% | 51.90% | 95.85% | 66.74% | 42.98% | 11.47% | 1.66% | 2.03% | 16.87% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/31/2025- NAV $79.76
- NAV Change $-0.02
- Market Price $79.78
- Market Price Change $+0.02
- Trading Volume (M) 6,711
- 30-Day Median Bid Ask Spread 0.25%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/31/2025- NAV $79.76
- NAV Change $-0.02
- Market Price $79.78
- Market Price Change $+0.02
- Trading Volume (M) 6,711
- 30-Day Median Bid Ask Spread 0.25%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 12/31/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 6.00% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,024,135.52 | 11,082 | 2931034 |
| 5.59% | GILD | GILEAD SCIENCES INC | -- | $4,684,985.80 | 38,170 | 2369174 |
| 5.43% | AMGN | AMGEN INC | -- | $4,551,572.86 | 13,906 | 2023607 |
| 4.20% | REGN | REGENERON PHARMACEUTICALS | -- | $3,521,270.94 | 4,562 | 2730190 |
| 2.83% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $2,370,690.84 | 25,788 | 2989044 |
| 2.77% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,320,287.75 | 5,835 | B00FWN1 |
| 1.96% | INSM | INSMED INC | -- | $1,639,456.80 | 9,420 | 2614487 |
| 1.36% | BIIB | BIOGEN INC | -- | $1,140,415.20 | 6,480 | 2455965 |
| 1.29% | ARGX | ARGENX SE - ADR | -- | $1,081,461.70 | 1,286 | BDVLM39 |
| 1.11% | UTHR | UNITED THERAPEUTICS CORP | -- | $926,749.50 | 1,902 | 2430412 |
| 1.06% | ILMN | ILLUMINA INC | -- | $885,198.84 | 6,749 | 2613990 |
| 1.02% | INCY | INCYTE CORP | -- | $856,434.67 | 8,671 | 2471950 |
| 0.87% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $729,175.44 | 18,871 | BMVP7Y0 |
| 0.83% | MEDP | MEDPACE HOLDINGS INC | -- | $698,692.60 | 1,244 | BDCBC61 |
| 0.81% | RVMD | REVOLUTION MEDICINES INC | -- | $680,131.35 | 8,539 | BL71K91 |
| 0.80% | ROIV | ROIVANT SCIENCES LTD | -- | $666,602.30 | 30,719 | BMW4NZ9 |
| 0.78% | BBIO | BRIDGEBIO PHARMA INC | -- | $651,082.88 | 8,512 | BK1KWG8 |
| 0.76% | VTRS | VIATRIS INC | -- | $633,107.40 | 50,852 | BMWS3X9 |
| 0.75% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $624,619.32 | 4,404 | 2623911 |
| 0.70% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $584,087.02 | 1,003 | BD59BS7 |
| 0.70% | GH | GUARDANT HEALTH INC | -- | $583,627.96 | 5,714 | BFXC911 |
| 0.69% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $578,306.88 | 2,712 | BV9G6B8 |
| 0.69% | SMMT | SUMMIT THERAPEUTICS INC | -- | $575,088.69 | 32,881 | BMTVQS7 |
| 0.68% | SNY | SANOFI-ADR | -- | $566,400.48 | 11,688 | 2964557 |
| 0.68% | IONS | IONIS PHARMACEUTICALS INC | -- | $565,952.94 | 7,154 | BDJ0LS6 |
| 0.62% | EXEL | EXELIXIS INC | -- | $519,034.86 | 11,842 | 2576941 |
| 0.61% | MRNA | MODERNA INC | -- | $508,731.99 | 17,251 | BGSXTS3 |
| 0.60% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $503,788.11 | 8,477 | 2437071 |
| 0.57% | RNA | AVIDITY BIOSCIENCES INC | -- | $480,025.15 | 6,655 | BMWHPY1 |
| 0.54% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $456,280.00 | 2,684 | B4Q5ZN4 |
| 0.54% | TEM | TEMPUS AI INC | -- | $450,846.75 | 7,635 | BSLSJJ0 |
| 0.51% | BNTX | BIONTECH SE-ADR | -- | $424,972.80 | 4,464 | BK6H543 |
| 0.50% | ONC | BEONE MEDICINES LTD-ADR | -- | $422,295.90 | 1,390 | BYYWPW6 |
| 0.49% | AXSM | AXSOME THERAPEUTICS INC | -- | $406,739.28 | 2,227 | BYZR4X4 |
| 0.48% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $398,273.61 | 5,999 | BYQBFJ8 |
| 0.43% | CYTK | CYTOKINETICS INC | -- | $363,004.02 | 5,713 | BBBSBJ5 |
| 0.42% | -- | ABIVAX SA ADR USD 0.01 | -- | $351,566.99 | 2,607 | -- |
| 0.42% | HALO | HALOZYME THERAPEUTICS INC | -- | $349,556.20 | 5,194 | 2975098 |
| 0.40% | -- | CARIS LIFE SCIENCES INC COMMON STOCK USD 0.001 | -- | $336,224.76 | 12,462 | -- |
| 0.39% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $325,687.70 | 1,105 | BQ721R4 |
| 0.38% | NUVL | NUVALENT INC-A | -- | $320,882.10 | 3,190 | BMVBZD3 |
| 0.38% | KRYS | KRYSTAL BIOTECH INC | -- | $315,817.74 | 1,281 | BD6JX35 |
| 0.38% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $315,553.92 | 2,948 | BF2YWG4 |
| 0.32% | PTCT | PTC THERAPEUTICS INC | -- | $269,354.16 | 3,546 | B17VCN9 |
| 0.32% | PCVX | VAXCYTE INC | -- | $266,966.04 | 5,786 | BKPVGH6 |
| 0.30% | KYMR | KYMERA THERAPEUTICS INC | -- | $247,280.18 | 3,178 | BMPRZV5 |
| 0.29% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $241,145.74 | 2,761 | BDCBCD8 |
| 0.29% | COGT | COGENT BIOSCIENCES INC | -- | $240,719.04 | 6,777 | BLR6XK8 |
| 0.26% | CRSP | CRISPR THERAPEUTICS AG | -- | $220,300.44 | 4,201 | BDHF4K6 |
| 0.25% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $205,659.35 | 2,957 | BQS9486 |
| 0.24% | ALKS | ALKERMES PLC | -- | $204,142.08 | 7,296 | B3P6D26 |
| 0.24% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $199,603.83 | 7,473 | 2713317 |
| 0.24% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $198,489.30 | 4,506 | BFZQ0L8 |
| 0.24% | INDV | INDIVIOR PLC | -- | $197,878.20 | 5,515 | BP0BQQ5 |
| 0.23% | IMVT | IMMUNOVANT INC | -- | $196,750.80 | 7,740 | BJRFSB7 |
| 0.23% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $195,091.05 | 4,191 | BDD19F8 |
| 0.23% | FOLD | AMICUS THERAPEUTICS INC | -- | $194,062.72 | 13,628 | B19FQ48 |
| 0.23% | ADMA | ADMA BIOLOGICS INC | -- | $191,738.88 | 10,512 | B9NSBM2 |
| 0.22% | APGE | APOGEE THERAPEUTICS INC | -- | $182,812.56 | 2,422 | BM9HHL5 |
| 0.21% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $179,307.30 | 2,270 | BJDX8Y8 |
| 0.21% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $175,680.64 | 5,008 | BP8JSP4 |
| 0.21% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $174,888.00 | 13,880 | BFNF1D6 |
| 0.20% | ACLX | ARCELLX INC | -- | $166,520.80 | 2,554 | BPCJ1Q2 |
| 0.20% | LGND | LIGAND PHARMACEUTICALS | -- | $164,301.83 | 869 | 2501578 |
| 0.19% | TERN | TERNS PHARMACEUTICALS INC | -- | $160,751.60 | 3,979 | BMDJ0C9 |
| 0.19% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $157,106.40 | 5,410 | BKX9VD3 |
| 0.18% | TARS | TARSUS PHARMACEUTICALS INC | -- | $153,525.00 | 1,875 | BMH5RL1 |
| 0.18% | XENE | XENON PHARMACEUTICALS INC | -- | $152,970.66 | 3,413 | BRJ3GY4 |
| 0.18% | TVTX | TRAVERE THERAPEUTICS INC | -- | $151,005.92 | 3,952 | BLFGJD5 |
| 0.18% | CGON | CG ONCOLOGY INC | -- | $147,769.68 | 3,559 | BRBCSP4 |
| 0.18% | GRAL | GRAIL INC | -- | $147,385.98 | 1,722 | BSLSSX7 |
| 0.18% | VCYT | VERACYTE INC | -- | $147,223.70 | 3,497 | BFTWZY0 |
| 0.17% | VERA | VERA THERAPEUTICS INC | -- | $143,007.36 | 2,824 | BL55460 |
| 0.17% | APLS | APELLIS PHARMACEUTICALS INC | -- | $140,370.56 | 5,588 | BYTQ6X1 |
| 0.16% | IDYA | IDEAYA BIOSCIENCES INC | -- | $133,855.04 | 3,872 | BK0VHF6 |
| 0.16% | IRON | DISC MEDICINE INC | -- | $132,376.47 | 1,667 | BMGJZJ8 |
| 0.15% | MLYS | MINERALYS THERAPEUTICS INC | -- | $126,869.84 | 3,496 | BP9N0G0 |
| 0.15% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $125,890.10 | 2,533 | B72ZBG4 |
| 0.15% | WVE | WAVE LIFE SCIENCES LTD | -- | $125,528.00 | 7,384 | BYZG9R0 |
| 0.15% | BEAM | BEAM THERAPEUTICS INC | -- | $124,241.04 | 4,482 | BK6L288 |
| 0.15% | DYN | DYNE THERAPEUTICS INC | -- | $123,384.48 | 6,308 | BN15WD1 |
| 0.14% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $116,034.94 | 4,676 | BKY5JZ8 |
| 0.14% | OCUL | OCULAR THERAPEUTIX INC | -- | $114,188.84 | 9,406 | BNZB1X8 |
| 0.13% | SYRE | SPYRE THERAPEUTICS INC | -- | $112,268.52 | 3,427 | BQBBDY8 |
| 0.13% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $109,506.32 | 6,743 | BJ5FZ74 |
| 0.13% | DNLI | DENALI THERAPEUTICS INC | -- | $106,951.78 | 6,478 | BD2B4V0 |
| 0.13% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $106,567.61 | 4,261 | BLB0YQ9 |
| 0.12% | SRPT | SAREPTA THERAPEUTICS INC | -- | $99,357.84 | 4,617 | B8DPDT7 |
| 0.12% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $98,003.00 | 4,261 | BJ62Z18 |
| 0.11% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $95,196.48 | 2,544 | BKSGZN7 |
| 0.11% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $92,887.99 | 22,711 | BM9FJ13 |
| 0.11% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $92,876.85 | 5,823 | BFWLC09 |
| 0.11% | MAZE | MAZE THERAPEUTICS INC | -- | $88,038.75 | 2,125 | BSRK699 |
| 0.10% | ZYME | ZYMEWORKS INC | -- | $87,020.65 | 3,305 | BPCQZY9 |
| 0.10% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $86,850.00 | 3,474 | BMZ4LN0 |
| 0.10% | IBRX | IMMUNITYBIO INC | -- | $86,139.90 | 43,505 | BNSP0B8 |
| 0.10% | ZBIO | ZENAS BIOPHARMA INC | -- | $86,091.01 | 2,371 | BQB42H3 |
| 0.10% | TWST | TWIST BIOSCIENCE CORP | -- | $85,612.28 | 2,699 | BGKG6G7 |
| 0.10% | NRIX | NURIX THERAPEUTICS INC | -- | $84,928.69 | 4,477 | BMVLGP2 |
| 0.10% | TXG | 10X GENOMICS INC-CLASS A | -- | $83,931.26 | 5,146 | BKS3RS7 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $82,293.75 | 1,995 | BRXB0C0 |
| 0.10% | SION | SIONNA THERAPEUTICS INC | -- | $81,086.94 | 1,971 | BQKXDX4 |
| 0.10% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $80,851.06 | 3,719 | BMX9K07 |
| 0.10% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $80,657.39 | 3,839 | BN7Q7R7 |
| 0.10% | VCEL | VERICEL CORP | -- | $80,446.34 | 2,234 | BSBMN89 |
| 0.10% | HROW | HARROW INC | -- | $80,164.00 | 1,636 | BHNDW86 |
| 0.10% | STOK | STOKE THERAPEUTICS INC | -- | $80,080.02 | 2,523 | BJQ05Z6 |
| 0.10% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $79,776.06 | 5,187 | BRJZSK0 |
| 0.09% | GMAB | GENMAB A/S -SP ADR | -- | $79,525.60 | 2,582 | BBC9WC7 |
| 0.09% | -- | PHARVARIS NV COMMON STOCK USD 0.12 | -- | $78,504.75 | 2,829 | -- |
| 0.09% | ANIP | ANI PHARMACEUTICALS INC | -- | $78,308.48 | 992 | BCDWBX6 |
| 0.09% | MNKD | MANNKIND CORP | -- | $76,902.21 | 13,563 | BF081J4 |
| 0.09% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $72,532.20 | 9,299 | 2100362 |
| 0.08% | ALVO | ALVOTECH SA | -- | $70,927.38 | 13,826 | BPNTJ34 |
| 0.08% | TRVI | TREVI THERAPEUTICS INC | -- | $70,913.28 | 5,664 | BJH9ZN0 |
| 0.08% | FTRE | FORTREA HOLDINGS INC | -- | $70,397.25 | 4,081 | BRXYZ57 |
| 0.08% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $70,118.72 | 2,576 | BCBVTX1 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $66,886.17 | 1,927 | BLCD809 |
| 0.08% | EYPT | EYEPOINT INC | -- | $66,813.39 | 3,657 | BMGS7L1 |
| 0.08% | TSHA | TAYSHA GENE THERAPIES INC | -- | $66,544.50 | 12,099 | BNC1BX1 |
| 0.08% | INVA | INNOVIVA INC | -- | $66,026.97 | 3,303 | BDDXF67 |
| 0.08% | QURE | UNIQURE NV | -- | $65,831.43 | 2,751 | BJFSR88 |
| 0.08% | ATAI | ATAI LIFE SCIENCES NV | -- | $65,611.78 | 16,042 | BN6M8F1 |
| 0.08% | KOD | KODIAK SCIENCES INC | -- | $65,510.28 | 2,343 | BFXC933 |
| 0.08% | PGEN | PRECIGEN INC | -- | $65,178.74 | 15,593 | BKM5C84 |
| 0.08% | UPB | UPSTREAM BIO INC | -- | $64,807.05 | 2,387 | BRCFFK6 |
| 0.08% | ORKA | ORUKA THERAPEUTICS INC | -- | $64,802.78 | 2,138 | BKVF0J2 |
| 0.08% | RLAY | RELAY THERAPEUTICS INC | -- | $64,761.30 | 7,655 | BN2R582 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $64,634.80 | 1,396 | BX7RSN3 |
| 0.08% | NVCR | NOVOCURE LTD | -- | $63,951.78 | 4,946 | BYSS4X4 |
| 0.08% | RAPP | RAPPORT THERAPEUTICS INC | -- | $63,926.38 | 2,107 | BR3T9B6 |
| 0.07% | ARDX | ARDELYX INC | -- | $62,567.56 | 10,732 | BN89V40 |
| 0.07% | MBX | MBX BIOSCIENCES INC | -- | $62,543.82 | 1,983 | BQXJKH2 |
| 0.07% | TYRA | TYRA BIOSCIENCES INC | -- | $61,965.53 | 2,357 | BMVNDH9 |
| 0.07% | ANAB | ANAPTYSBIO INC | -- | $59,291.04 | 1,223 | BDRW1L7 |
| 0.07% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $58,600.08 | 4,851 | BPCK358 |
| 0.07% | MNMD | MIND MEDICINE MINDMED INC | -- | $58,259.89 | 4,351 | BPQYY97 |
| 0.07% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $57,532.65 | 7,329 | BLR7H87 |
| 0.07% | SEPN | SEPTERNA INC | -- | $55,146.64 | 1,978 | BQNKXX2 |
| 0.06% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $54,363.40 | 2,030 | BNFWZS4 |
| 0.06% | SVRA | SAVARA INC | -- | $54,191.61 | 8,987 | BYXGN81 |
| 0.06% | OMER | OMEROS CORP | -- | $53,792.10 | 3,132 | B4NB858 |
| 0.06% | TNGX | TANGO THERAPEUTICS INC | -- | $52,708.14 | 5,949 | BP2P6L0 |
| 0.06% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $52,125.78 | 3,142 | BJLKVS6 |
| 0.06% | SPRY | ARS PHARMACEUTICALS INC | -- | $50,863.90 | 4,366 | BMCR7V2 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $50,718.00 | 642 | BNSP8K3 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $50,377.80 | 5,388 | B8K7T65 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $50,142.10 | 1,289 | BKLCWZ3 |
| 0.06% | PCRX | PACIRA BIOSCIENCES INC | -- | $49,172.00 | 1,900 | B3X26D8 |
| 0.06% | URGN | UROGEN PHARMA LTD | -- | $48,432.56 | 2,068 | BZ7PJQ1 |
| 0.06% | XNCR | XENCOR INC | -- | $48,287.74 | 3,154 | BGCYWN8 |
| 0.06% | NVAX | NOVAVAX INC | -- | $48,229.44 | 7,177 | BJDQXG4 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $47,883.55 | 11,765 | BMFJJ97 |
| 0.06% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $47,867.82 | 17,534 | BF0DMK7 |
| 0.06% | ERAS | ERASCA INC | -- | $46,615.32 | 12,531 | BNLYBF3 |
| 0.05% | NTLA | INTELLIA THERAPEUTICS INC | -- | $45,947.89 | 5,111 | BYZM6C2 |
| 0.05% | ABCL | ABCELLERA BIOLOGICS INC | -- | $45,280.80 | 13,240 | BL53SR3 |
| 0.05% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $45,095.68 | 2,876 | BP7KZP7 |
| 0.05% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $42,023.88 | 4,509 | BLB0YH0 |
| 0.05% | ALMS | ALUMIS INC | -- | $41,909.44 | 4,294 | BPLQG36 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $41,891.69 | 2,239 | BMNDK09 |
| 0.05% | -- | RAPT THERAPEUTICS INC | -- | $41,456.88 | 1,224 | BTJZB49 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $40,860.95 | 8,495 | BZ0QMB7 |
| 0.05% | BCAX | BICARA THERAPEUTICS INC | -- | $40,728.60 | 2,420 | BQB42F1 |
| 0.05% | CRMD | CORMEDIX INC | -- | $40,472.40 | 3,480 | BJ0LT31 |
| 0.05% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $40,363.40 | 2,621 | BMFD115 |
| 0.05% | KURA | KURA ONCOLOGY INC | -- | $39,856.04 | 3,836 | BYZD465 |
| 0.05% | MESO | MESOBLAST LTD- SPON ADR | -- | $39,074.64 | 2,166 | BQS7491 |
| 0.05% | ESPR | ESPERION THERAPEUTICS INC | -- | $39,068.30 | 10,559 | BBNBTD2 |
| 0.04% | GERN | GERON CORP | -- | $37,218.72 | 28,196 | 2370381 |
| 0.04% | VIR | VIR BIOTECHNOLOGY INC | -- | $37,054.35 | 6,145 | BK4PZ38 |
| 0.04% | AVBP | ARRIVENT BIOPHARMA INC | -- | $36,678.76 | 1,823 | BMGTLY5 |
| 0.04% | JANX | JANUX THERAPEUTICS INC | -- | $36,666.60 | 2,657 | BMFX8Y7 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $36,062.95 | 2,233 | BD06CS0 |
| 0.04% | ORIC | ORIC PHARMACEUTICALS INC | -- | $35,190.36 | 4,302 | BKVDFF7 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $34,812.94 | 5,389 | BYVQJ96 |
| 0.04% | -- | GH RESEARCH PLC COMMON STOCK USD 0.01 | -- | $34,798.00 | 2,740 | -- |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $34,349.66 | 802 | BQD3J33 |
| 0.04% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $33,736.08 | 903 | BL95N25 |
| 0.04% | REPL | REPLIMUNE GROUP INC | -- | $33,679.80 | 3,465 | BDDVW37 |
| 0.04% | ARVN | ARVINAS INC | -- | $33,646.82 | 2,837 | BDZ30Q0 |
| 0.04% | RGNX | REGENXBIO INC | -- | $32,198.40 | 2,236 | BZ0G875 |
| 0.04% | ANNX | ANNEXON INC | -- | $32,092.86 | 6,393 | BMVV9R5 |
| 0.04% | LXEO | LEXEO THERAPEUTICS INC | -- | $32,014.32 | 3,224 | BQ6C357 |
| 0.04% | CTMX | CYTOMX THERAPEUTICS INC | -- | $31,881.84 | 7,484 | BYWVTY5 |
| 0.04% | GOSS | GOSSAMER BIO INC | -- | $31,691.30 | 10,223 | BJ0CK86 |
| 0.04% | PSNL | PERSONALIS INC | -- | $31,187.28 | 3,918 | BJQ0608 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $30,499.56 | 1,729 | BD9GVY0 |
| 0.04% | IVVD | INVIVYD INC | -- | $30,232.80 | 12,240 | BM8NHS1 |
| 0.03% | LYEL | LYELL IMMUNOPHARMA INC | -- | $28,840.86 | 937 | BTNMG41 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $28,717.80 | 4,162 | BMC3HS7 |
| 0.03% | VTYX | VENTYX BIOSCIENCES INC | -- | $28,462.56 | 3,152 | BMG99Y1 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $28,262.25 | 3,555 | BFYQFJ2 |
| 0.03% | PRME | PRIME MEDICINE INC | -- | $27,666.31 | 7,973 | BPBJFM7 |
| 0.03% | KROS | KEROS THERAPEUTICS INC | -- | $27,404.56 | 1,346 | BM7V485 |
| 0.03% | FULC | FULCRUM THERAPEUTICS INC | -- | $27,030.90 | 2,390 | BJDX8Z9 |
| 0.03% | CGEM | CULLINAN THERAPEUTICS INC | -- | $27,003.15 | 2,609 | BM90J52 |
| 0.03% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $25,402.30 | 3,299 | BYP80F1 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $24,936.45 | 13,335 | B4N8MH9 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $24,213.45 | 7,185 | B3MZ6K5 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $23,600.08 | 2,516 | BMFK3H6 |
| 0.03% | ABSI | ABSCI CORP | -- | $23,180.58 | 6,642 | BN94K69 |
| 0.03% | VNDA | VANDA PHARMACEUTICALS INC | -- | $23,020.20 | 2,610 | B12W3P6 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $22,709.90 | 2,378 | B91XRN2 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $22,283.52 | 2,487 | BLFBZ32 |
| 0.03% | LENZ | LENZ THERAPEUTICS INC | -- | $22,112.00 | 1,382 | BQV0J03 |
| 0.03% | BIOA | BIOAGE LABS INC | -- | $20,956.32 | 1,584 | BT9K6D8 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $20,895.30 | 639 | B292NQ7 |
| 0.02% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $20,819.50 | 6,406 | BMCWKZ2 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $20,106.75 | 1,275 | B9L5200 |
| 0.02% | ETON | ETON PHARMACEUTICALS INC | -- | $20,038.35 | 1,185 | BGL0JK3 |
| 0.02% | PEPG | PEPGEN INC | -- | $19,770.87 | 3,037 | BMTX3D7 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $19,407.24 | 3,441 | BQHN6C7 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $19,325.93 | 3,163 | 2107437 |
| 0.02% | EOLS | EVOLUS INC | -- | $19,038.95 | 2,863 | BDRJH21 |
| 0.02% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $18,930.00 | 2,524 | BKLXFX5 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $18,766.16 | 2,852 | BMVBZF5 |
| 0.02% | IMAB | I-MAB-SPONSORED ADR | -- | $18,276.16 | 4,592 | BKRRKY7 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $18,226.60 | 1,939 | BSMLR16 |
| 0.02% | KMDA | KAMADA LTD | -- | $17,988.88 | 2,548 | B2Q9833 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $17,631.40 | 8,860 | BFMLGR4 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $17,352.64 | 1,688 | BP81RK8 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $17,251.22 | 827 | BPBPCG8 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $16,777.80 | 4,780 | BDFKQ07 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $16,638.49 | 4,609 | BFY7DC4 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $15,287.25 | 2,805 | BP81R42 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $14,471.52 | 2,044 | BKDQKM6 |
| 0.02% | ACRS | ACLARIS THERAPEUTICS INC | -- | $14,405.86 | 4,786 | BYV2W40 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $14,401.80 | 3,780 | BMXNGZ6 |
| 0.02% | NGNE | NEUROGENE INC | -- | $14,090.40 | 684 | BS2F741 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $14,047.76 | 3,946 | BYTYP72 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $13,925.90 | 4,435 | BZC0D70 |
| 0.02% | CADL | CANDEL THERAPEUTICS INC | -- | $13,701.25 | 2,425 | BP0TQC5 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $13,598.62 | 9,926 | BFZNYB7 |
| 0.02% | LFCR | LIFECORE BIOMEDICAL INC | -- | $13,537.90 | 1,655 | 2517058 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $13,489.20 | 2,498 | BMF7DT9 |
| 0.02% | -- | JYONG BIOTECH LTD COMMON STOCK USD 0.00001 | -- | $13,264.10 | 3,358 | -- |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $13,244.70 | 2,226 | B7F2TY6 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $13,210.20 | 7,380 | BN4JN37 |
| 0.02% | AARD | AARDVARK THERAPEUTICS INC | -- | $12,626.25 | 962 | BTXQTX3 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $12,609.92 | 2,074 | BL5B6Z1 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $12,320.07 | 3,451 | BLN9Z50 |
| 0.01% | OABI | OMNIAB INC | -- | $11,762.30 | 6,358 | BN13S71 |
| 0.01% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $11,658.60 | 1,020 | BPRBTY7 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $10,350.10 | 2,494 | BPRB2N7 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $10,241.58 | 2,606 | BY7RB53 |
| 0.01% | -- | VOR BIOPHARMA INC COMMON STOCK USD 0.0001 | -- | $9,731.52 | 744 | -- |
| 0.01% | QSI | QUANTUM-SI INC | -- | $9,500.70 | 8,637 | BNR5QT9 |
| 0.01% | CABA | CABALETTA BIO INC | -- | $9,311.88 | 4,252 | BK5MWR1 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $8,983.20 | 2,364 | BP7L561 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $8,839.60 | 4,312 | BZ8FPH3 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $8,176.71 | 4,281 | BKX9NQ0 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $8,104.48 | 1,369 | BP2NYN2 |
| 0.01% | HUMA | HUMACYTE INC | -- | $7,945.26 | 8,272 | BMYTJP4 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $7,693.15 | 1,255 | BKC9SX3 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $7,581.38 | 5,339 | BRK0149 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $6,563.52 | 4,128 | BNYJR68 |
| 0.01% | CDXS | CODEXIS INC | -- | $6,503.70 | 3,990 | B5LL2C2 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $6,116.31 | 2,517 | BKTV702 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $5,815.80 | 4,308 | BNNXX18 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $5,232.37 | 7,354 | BNNXX52 |
| -- | PYXS | PYXIS ONCOLOGY INC | -- | $3,162.50 | 2,750 | BLBR8D5 |
| -- | -- | SUTRO BIOPHARMA INC COMMON STOCK USD 0.001 | -- | $11.57 | 01 | -- |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| 35.70% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 29,894,314 | -- | 5,238 | -- |
| 33.24% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 27,839,722 | -- | 4,878 | -- |
| 24.02% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 20,117,880 | -- | 3,525 | -- |
| 16.93% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,176,685 | -- | 2,484 | -- |
| 15.67% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 13,120,853 | -- | 2,299 | -- |
| 4.31% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,612,658 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $24,862,815.12 | 24,862,815 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
Read More