BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 11/30/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 16.90% | 51.72% | 95.62% | 66.67% | 42.59% | 11.36% | 1.61% | 2.01% | 16.86% | 04/07/2010 |
| BIB Market Price | 17.00% | 51.90% | 95.85% | 66.74% | 42.98% | 11.47% | 1.66% | 2.03% | 16.87% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/18/2025- NAV $77.22
- NAV Change $-1.19
- Market Price $77.21
- Market Price Change $-1.16
- Trading Volume (M) 20,344
- 30-Day Median Bid Ask Spread 0.26%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/18/2025- NAV $77.22
- NAV Change $-1.19
- Market Price $77.21
- Market Price Change $-1.16
- Trading Volume (M) 20,344
- 30-Day Median Bid Ask Spread 0.26%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 12/18/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.58% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $4,520,774.90 | 10,105 | 2931034 |
| 5.49% | AMGN | AMGEN INC | -- | $4,455,259.86 | 13,733 | 2023607 |
| 5.24% | GILD | GILEAD SCIENCES INC | -- | $4,248,413.25 | 34,975 | 2369174 |
| 4.56% | REGN | REGENERON PHARMACEUTICALS | -- | $3,693,386.43 | 4,933 | 2730190 |
| 3.03% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,458,220.28 | 6,207 | B00FWN1 |
| 2.76% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $2,240,422.86 | 24,726 | 2989044 |
| 2.07% | INSM | INSMED INC | -- | $1,680,656.05 | 10,091 | 2614487 |
| 1.53% | ARGX | ARGENX SE - ADR | -- | $1,238,387.10 | 1,462 | BDVLM39 |
| 1.47% | BIIB | BIOGEN INC | -- | $1,189,370.00 | 7,000 | 2455965 |
| 1.35% | UTHR | UNITED THERAPEUTICS CORP | -- | $1,094,613.00 | 2,159 | 2430412 |
| 1.18% | ILMN | ILLUMINA INC | -- | $957,812.89 | 7,339 | 2613990 |
| 1.12% | INCY | INCYTE CORP | -- | $907,318.44 | 9,324 | 2471950 |
| 0.98% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $793,233.63 | 20,641 | BMVP7Y0 |
| 0.93% | MEDP | MEDPACE HOLDINGS INC | -- | $751,241.61 | 1,341 | BDCBC61 |
| 0.88% | ROIV | ROIVANT SCIENCES LTD | -- | $710,462.95 | 32,605 | BMW4NZ9 |
| 0.84% | RVMD | REVOLUTION MEDICINES INC | -- | $677,943.00 | 8,925 | BL71K91 |
| 0.83% | BBIO | BRIDGEBIO PHARMA INC | -- | $676,749.92 | 9,128 | BK1KWG8 |
| 0.83% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $671,754.24 | 4,736 | 2623911 |
| 0.82% | VTRS | VIATRIS INC | -- | $664,652.04 | 55,666 | BMWS3X9 |
| 0.76% | SNY | SANOFI-ADR | -- | $614,799.89 | 12,811 | 2964557 |
| 0.75% | SMMT | SUMMIT THERAPEUTICS INC | -- | $604,374.72 | 35,468 | BMTVQS7 |
| 0.73% | IONS | IONIS PHARMACEUTICALS INC | -- | $590,764.30 | 7,610 | BDJ0LS6 |
| 0.72% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $580,419.00 | 2,905 | BV9G6B8 |
| 0.71% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $579,252.24 | 1,064 | BD59BS7 |
| 0.71% | GH | GUARDANT HEALTH INC | -- | $578,133.40 | 5,954 | BFXC911 |
| 0.71% | MRNA | MODERNA INC | -- | $574,958.15 | 18,577 | BGSXTS3 |
| 0.67% | EXEL | EXELIXIS INC | -- | $547,152.21 | 12,853 | 2576941 |
| 0.62% | TEM | TEMPUS AI INC | -- | $501,101.55 | 8,055 | BSLSJJ0 |
| 0.61% | ONC | BEONE MEDICINES LTD-ADR | -- | $492,767.10 | 1,605 | BYYWPW6 |
| 0.59% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $480,736.00 | 2,896 | B4Q5ZN4 |
| 0.59% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $476,537.35 | 9,173 | 2437071 |
| 0.55% | RNA | AVIDITY BIOSCIENCES INC | -- | $443,125.31 | 6,143 | BMWHPY1 |
| 0.54% | BNTX | BIONTECH SE-ADR | -- | $439,282.38 | 4,803 | BK6H543 |
| 0.54% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $438,768.47 | 6,601 | BYQBFJ8 |
| 0.45% | HALO | HALOZYME THERAPEUTICS INC | -- | $363,639.35 | 5,585 | 2975098 |
| 0.44% | CYTK | CYTOKINETICS INC | -- | $355,348.60 | 5,713 | BBBSBJ5 |
| 0.44% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $354,519.29 | 3,173 | BF2YWG4 |
| 0.43% | AXSM | AXSOME THERAPEUTICS INC | -- | $350,301.00 | 2,383 | BYZR4X4 |
| 0.40% | NUVL | NUVALENT INC-A | -- | $322,788.03 | 3,183 | BMVBZD3 |
| 0.40% | KRYS | KRYSTAL BIOTECH INC | -- | $322,517.34 | 1,382 | BD6JX35 |
| 0.35% | PTCT | PTC THERAPEUTICS INC | -- | $282,919.87 | 3,793 | B17VCN9 |
| 0.34% | KYMR | KYMERA THERAPEUTICS INC | -- | $271,856.82 | 3,414 | BMPRZV5 |
| 0.33% | PCVX | VAXCYTE INC | -- | $270,958.29 | 6,199 | BKPVGH6 |
| 0.33% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $270,606.30 | 1,005 | BQ721R4 |
| 0.31% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $254,796.30 | 2,970 | BDCBCD8 |
| 0.31% | COGT | COGENT BIOSCIENCES INC | -- | $252,793.00 | 6,670 | BLR6XK8 |
| 0.29% | CRSP | CRISPR THERAPEUTICS AG | -- | $238,170.12 | 4,343 | BDHF4K6 |
| 0.27% | ALKS | ALKERMES PLC | -- | $219,198.42 | 7,882 | B3P6D26 |
| 0.27% | IMVT | IMMUNOVANT INC | -- | $217,896.14 | 8,323 | BJRFSB7 |
| 0.26% | ADMA | ADMA BIOLOGICS INC | -- | $214,321.14 | 11,394 | B9NSBM2 |
| 0.26% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $214,263.00 | 8,055 | 2713317 |
| 0.26% | INDV | INDIVIOR PLC | -- | $211,711.78 | 5,957 | BP0BQQ5 |
| 0.25% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $202,994.58 | 4,497 | BDD19F8 |
| 0.24% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $197,048.70 | 4,590 | BFZQ0L8 |
| 0.23% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $189,549.44 | 14,996 | BFNF1D6 |
| 0.23% | LGND | LIGAND PHARMACEUTICALS | -- | $185,711.76 | 936 | 2501578 |
| 0.22% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $182,314.20 | 5,378 | BP8JSP4 |
| 0.22% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $177,233.10 | 2,838 | BQS9486 |
| 0.21% | APGE | APOGEE THERAPEUTICS INC | -- | $170,324.70 | 2,202 | BM9HHL5 |
| 0.21% | ACLX | ARCELLX INC | -- | $169,816.24 | 2,648 | BPCJ1Q2 |
| 0.21% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $168,601.72 | 2,399 | BJDX8Y8 |
| 0.21% | TERN | TERNS PHARMACEUTICALS INC | -- | $166,367.96 | 4,178 | BMDJ0C9 |
| 0.20% | FOLD | AMICUS THERAPEUTICS INC | -- | $160,268.13 | 14,717 | B19FQ48 |
| 0.20% | XENE | XENON PHARMACEUTICALS INC | -- | $159,172.86 | 3,682 | BRJ3GY4 |
| 0.20% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $159,040.50 | 5,725 | BKX9VD3 |
| 0.19% | VCYT | VERACYTE INC | -- | $157,902.24 | 3,756 | BFTWZY0 |
| 0.19% | TARS | TARSUS PHARMACEUTICALS INC | -- | $156,199.68 | 2,016 | BMH5RL1 |
| 0.19% | GRAL | GRAIL INC | -- | $151,990.12 | 1,721 | BSLSSX7 |
| 0.19% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $151,096.84 | 4,601 | BJ62Z18 |
| 0.19% | IRON | DISC MEDICINE INC | -- | $150,130.40 | 1,660 | BMGJZJ8 |
| 0.18% | APLS | APELLIS PHARMACEUTICALS INC | -- | $147,614.40 | 6,030 | BYTQ6X1 |
| 0.18% | TVTX | TRAVERE THERAPEUTICS INC | -- | $146,789.44 | 4,256 | BLFGJD5 |
| 0.18% | VERA | VERA THERAPEUTICS INC | -- | $145,311.43 | 3,047 | BL55460 |
| 0.17% | IDYA | IDEAYA BIOSCIENCES INC | -- | $139,193.10 | 4,185 | BK0VHF6 |
| 0.17% | CGON | CG ONCOLOGY INC | -- | $138,358.00 | 3,641 | BRBCSP4 |
| 0.16% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $131,922.56 | 2,677 | B72ZBG4 |
| 0.16% | BEAM | BEAM THERAPEUTICS INC | -- | $126,401.10 | 4,830 | BK6L288 |
| 0.16% | DYN | DYNE THERAPEUTICS INC | -- | $126,010.15 | 6,793 | BN15WD1 |
| 0.15% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $119,971.50 | 7,271 | BJ5FZ74 |
| 0.15% | WVE | WAVE LIFE SCIENCES LTD | -- | $118,072.92 | 7,598 | BYZG9R0 |
| 0.14% | MLYS | MINERALYS THERAPEUTICS INC | -- | $117,105.00 | 3,165 | BP9N0G0 |
| 0.14% | DNLI | DENALI THERAPEUTICS INC | -- | $117,071.37 | 6,981 | BD2B4V0 |
| 0.14% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $113,837.85 | 4,581 | BLB0YQ9 |
| 0.13% | OCUL | OCULAR THERAPEUTIX INC | -- | $107,837.84 | 8,308 | BNZB1X8 |
| 0.13% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $106,384.50 | 5,030 | BKY5JZ8 |
| 0.13% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $102,930.09 | 2,747 | BKSGZN7 |
| 0.12% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $100,964.37 | 3,277 | BMZ4LN0 |
| 0.12% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $99,867.07 | 6,277 | BFWLC09 |
| 0.12% | AVDL | AVADEL PHARMACEUTICALS | -- | $99,303.12 | 4,636 | BDGMC59 |
| 0.12% | SYRE | SPYRE THERAPEUTICS INC | -- | $96,527.48 | 2,884 | BQBBDY8 |
| 0.12% | SRPT | SAREPTA THERAPEUTICS INC | -- | $94,886.10 | 4,665 | B8DPDT7 |
| 0.12% | ZYME | ZYMEWORKS INC | -- | $94,749.60 | 3,589 | BPCQZY9 |
| 0.12% | IBRX | IMMUNITYBIO INC | -- | $94,327.97 | 45,133 | BNSP0B8 |
| 0.11% | TWST | TWIST BIOSCIENCE CORP | -- | $92,025.36 | 2,883 | BGKG6G7 |
| 0.11% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $90,589.32 | 20,403 | BM9FJ13 |
| 0.11% | MNKD | MANNKIND CORP | -- | $87,460.50 | 14,650 | BF081J4 |
| 0.11% | TXG | 10X GENOMICS INC-CLASS A | -- | $87,408.00 | 5,463 | BKS3RS7 |
| 0.11% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $87,192.00 | 2,076 | BRXB0C0 |
| 0.11% | VCEL | VERICEL CORP | -- | $87,109.44 | 2,409 | BSBMN89 |
| 0.11% | ANIP | ANI PHARMACEUTICALS INC | -- | $85,811.88 | 1,036 | BCDWBX6 |
| 0.11% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $85,545.60 | 4,020 | BMX9K07 |
| 0.10% | STOK | STOKE THERAPEUTICS INC | -- | $83,528.88 | 2,616 | BJQ05Z6 |
| 0.10% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $83,205.99 | 4,113 | BN7Q7R7 |
| 0.10% | HROW | HARROW INC | -- | $78,737.52 | 1,767 | BHNDW86 |
| 0.09% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $74,192.32 | 1,504 | BX7RSN3 |
| 0.09% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $73,067.67 | 10,023 | 2100362 |
| 0.09% | FTRE | FORTREA HOLDINGS INC | -- | $72,004.35 | 4,335 | BRXYZ57 |
| 0.09% | TSHA | TAYSHA GENE THERAPIES INC | -- | $70,986.25 | 13,025 | BNC1BX1 |
| 0.09% | TRVI | TREVI THERAPEUTICS INC | -- | $70,872.66 | 5,814 | BJH9ZN0 |
| 0.09% | ALVO | ALVOTECH SA | -- | $70,694.58 | 14,946 | BPNTJ34 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $68,640.80 | 1,912 | BLCD809 |
| 0.08% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $68,601.02 | 2,774 | BCBVTX1 |
| 0.08% | NVCR | NOVOCURE LTD | -- | $67,045.28 | 5,338 | BYSS4X4 |
| 0.08% | RLAY | RELAY THERAPEUTICS INC | -- | $66,926.16 | 8,232 | BN2R582 |
| 0.08% | NRIX | NURIX THERAPEUTICS INC | -- | $65,736.50 | 3,650 | BMVLGP2 |
| 0.08% | ARDX | ARDELYX INC | -- | $65,354.08 | 11,506 | BN89V40 |
| 0.08% | ANAB | ANAPTYSBIO INC | -- | $63,547.61 | 1,337 | BDRW1L7 |
| 0.08% | GMAB | GENMAB A/S -SP ADR | -- | $63,063.00 | 2,002 | BBC9WC7 |
| 0.08% | QURE | UNIQURE NV | -- | $62,696.60 | 2,620 | BJFSR88 |
| 0.08% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $60,861.13 | 5,599 | BRJZSK0 |
| 0.07% | INVA | INNOVIVA INC | -- | $60,390.63 | 3,009 | BDDXF67 |
| 0.07% | PGEN | PRECIGEN INC | -- | $59,326.59 | 14,227 | BKM5C84 |
| 0.07% | INBX | INHIBRX BIOSCIENCES INC | -- | $59,041.44 | 692 | BNSP8K3 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $58,830.00 | 2,220 | BNFWZS4 |
| 0.07% | TYRA | TYRA BIOSCIENCES INC | -- | $58,509.55 | 2,545 | BMVNDH9 |
| 0.07% | EYPT | EYEPOINT INC | -- | $56,144.46 | 3,291 | BMGS7L1 |
| 0.07% | SANA | SANA BIOTECHNOLOGY INC | -- | $55,584.00 | 12,352 | BMFJJ97 |
| 0.07% | PCRX | PACIRA BIOSCIENCES INC | -- | $55,512.60 | 2,145 | B3X26D8 |
| 0.07% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $55,140.36 | 3,387 | BJLKVS6 |
| 0.07% | CSTL | CASTLE BIOSCIENCES INC | -- | $54,846.00 | 1,385 | BKLCWZ3 |
| 0.07% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $54,047.10 | 7,710 | BLR7H87 |
| 0.07% | XNCR | XENCOR INC | -- | $53,424.45 | 3,405 | BGCYWN8 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $51,959.00 | 5,825 | B8K7T65 |
| 0.06% | NVAX | NOVAVAX INC | -- | $51,803.40 | 7,755 | BJDQXG4 |
| 0.06% | RAPP | RAPPORT THERAPEUTICS INC | -- | $51,662.52 | 1,743 | BR3T9B6 |
| 0.06% | ALMS | ALUMIS INC | -- | $51,163.56 | 4,626 | BPLQG36 |
| 0.06% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $50,743.44 | 4,257 | BPCK358 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $50,366.04 | 14,268 | BL53SR3 |
| 0.06% | ORKA | ORUKA THERAPEUTICS INC | -- | $50,332.20 | 1,788 | BKVF0J2 |
| 0.06% | SVRA | SAVARA INC | -- | $50,007.12 | 8,252 | BYXGN81 |
| 0.06% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $48,763.27 | 4,891 | BLB0YH0 |
| 0.06% | ERAS | ERASCA INC | -- | $48,758.40 | 13,544 | BNLYBF3 |
| 0.06% | URGN | UROGEN PHARMA LTD | -- | $47,979.48 | 2,209 | BZ7PJQ1 |
| 0.06% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $47,171.04 | 2,828 | BMFD115 |
| 0.06% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $46,682.67 | 2,949 | BP7KZP7 |
| 0.06% | SPRY | ARS PHARMACEUTICALS INC | -- | $46,340.58 | 4,719 | BMCR7V2 |
| 0.06% | MNMD | MIND MEDICINE MINDMED INC | -- | $45,557.82 | 3,633 | BPQYY97 |
| 0.06% | NTLA | INTELLIA THERAPEUTICS INC | -- | $45,510.00 | 5,125 | BYZM6C2 |
| 0.06% | TNGX | TANGO THERAPEUTICS INC | -- | $44,939.52 | 5,312 | BP2P6L0 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $43,722.90 | 2,405 | BMNDK09 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $42,501.42 | 17,277 | BF0DMK7 |
| 0.05% | CRMD | CORMEDIX INC | -- | $42,482.88 | 3,564 | BJ0LT31 |
| 0.05% | MESO | MESOBLAST LTD- SPON ADR | -- | $41,924.40 | 2,254 | BQS7491 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $41,554.62 | 9,153 | BZ0QMB7 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $41,006.29 | 1,937 | BMGTLY5 |
| 0.05% | GERN | GERON CORP | -- | $40,820.42 | 30,463 | 2370381 |
| 0.05% | KURA | KURA ONCOLOGY INC | -- | $40,818.40 | 4,144 | BYZD465 |
| 0.05% | JANX | JANUX THERAPEUTICS INC | -- | $40,280.76 | 2,869 | BMFX8Y7 |
| 0.05% | ARVN | ARVINAS INC | -- | $39,570.24 | 3,508 | BDZ30Q0 |
| 0.05% | VIR | VIR BIOTECHNOLOGY INC | -- | $39,333.69 | 6,633 | BK4PZ38 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $39,278.52 | 972 | BL95N25 |
| 0.05% | ZLAB | ZAI LAB LTD-ADR | -- | $39,221.94 | 2,283 | BD9GVY0 |
| 0.05% | KROS | KEROS THERAPEUTICS INC | -- | $39,032.07 | 1,939 | BM7V485 |
| 0.05% | ORIC | ORIC PHARMACEUTICALS INC | -- | $37,490.15 | 4,637 | BKVDFF7 |
| 0.05% | ESPR | ESPERION THERAPEUTICS INC | -- | $36,582.60 | 9,627 | BBNBTD2 |
| 0.04% | REPL | REPLIMUNE GROUP INC | -- | $36,114.63 | 3,727 | BDDVW37 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $36,090.00 | 2,406 | BD06CS0 |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $35,755.12 | 856 | BQD3J33 |
| 0.04% | ATXS | ASTRIA THERAPEUTICS INC | -- | $34,253.45 | 2,695 | BMYRFN8 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $33,558.56 | 5,776 | BYVQJ96 |
| 0.04% | PSNL | PERSONALIS INC | -- | $33,554.45 | 4,234 | BJQ0608 |
| 0.04% | RGNX | REGENXBIO INC | -- | $32,586.12 | 2,412 | BZ0G875 |
| 0.04% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $30,574.36 | 3,841 | BFYQFJ2 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $30,056.40 | 8,349 | BPBJFM7 |
| 0.04% | OMER | OMEROS CORP | -- | $29,760.84 | 3,249 | B4NB858 |
| 0.04% | LYEL | LYELL IMMUNOPHARMA INC | -- | $29,692.46 | 917 | BTNMG41 |
| 0.03% | CGEM | CULLINAN THERAPEUTICS INC | -- | $28,153.58 | 2,821 | BM90J52 |
| 0.03% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $27,198.40 | 3,560 | BYP80F1 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $27,193.59 | 4,379 | BMC3HS7 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $26,962.96 | 14,342 | B4N8MH9 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $25,676.88 | 2,578 | BQ6C357 |
| 0.03% | ANNX | ANNEXON INC | -- | $25,290.54 | 5,247 | BMVV9R5 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $25,284.56 | 7,756 | B3MZ6K5 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $24,498.19 | 2,719 | BMFK3H6 |
| 0.03% | ABSI | ABSCI CORP | -- | $24,343.99 | 7,139 | BN94K69 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $24,316.16 | 6,908 | BMCWKZ2 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $24,106.60 | 2,570 | B91XRN2 |
| 0.03% | LENZ | LENZ THERAPEUTICS INC | -- | $23,249.34 | 1,362 | BQV0J03 |
| 0.03% | EOLS | EVOLUS INC | -- | $22,179.02 | 3,089 | BDRJH21 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $21,708.00 | 2,680 | BLFBZ32 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $21,634.92 | 684 | B292NQ7 |
| 0.03% | SIGA | SIGA TECHNOLOGIES INC | -- | $21,573.89 | 3,419 | 2107437 |
| 0.03% | ALT | ALTIMMUNE INC | -- | $21,280.70 | 4,214 | BFY7DC4 |
| 0.03% | LXRX | LEXICON PHARMACEUTICALS INC | -- | $20,474.18 | 17,351 | BWFZX59 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $19,903.36 | 1,816 | BP81RK8 |
| 0.02% | HCM | HUTCHMED CHINA-ADR | -- | $19,771.35 | 1,481 | BYXV9H7 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $19,631.04 | 3,718 | BQHN6C7 |
| 0.02% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $19,378.70 | 2,230 | BKLXFX5 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $18,816.07 | 2,821 | B12W3P6 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $17,143.48 | 2,966 | BP81R42 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $16,640.96 | 5,152 | BDFKQ07 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $16,404.41 | 893 | BPBPCG8 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $15,952.89 | 4,101 | BYTYP72 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $15,043.48 | 10,594 | BFZNYB7 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $15,035.89 | 9,577 | BFMLGR4 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $14,941.39 | 2,207 | BKDQKM6 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $14,835.13 | 1,021 | B9L5200 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $14,455.00 | 2,065 | BSMLR16 |
| 0.02% | CLYM | CLIMB BIO INC | -- | $14,173.68 | 3,236 | BMW5LX6 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $14,142.30 | 4,794 | BZC0D70 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $14,018.41 | 4,087 | BMXNGZ6 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $13,967.66 | 2,242 | BL5B6Z1 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $13,495.00 | 2,699 | BMF7DT9 |
| 0.02% | AMRN | AMARIN CORP PLC -ADR | -- | $13,318.29 | 963 | BN72KB0 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $13,299.04 | 7,732 | BN4JN37 |
| 0.02% | NGNE | NEUROGENE INC | -- | $13,129.68 | 681 | BS2F741 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $11,880.75 | 2,555 | BP7L561 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $11,859.57 | 3,789 | BLN9Z50 |
| 0.01% | OABI | OMNIAB INC | -- | $11,776.59 | 5,859 | BN13S71 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $10,909.76 | 2,648 | BY7RB53 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $10,088.55 | 4,293 | BZ8FPH3 |
| 0.01% | RNAC | CARTESIAN THERAPEUTICS INC | -- | $9,141.12 | 1,242 | BQB9HM8 |
| 0.01% | HUMA | HUMACYTE INC | -- | $8,393.82 | 7,562 | BMYTJP4 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $8,339.71 | 1,297 | BKC9SX3 |
| 0.01% | PEPG | PEPGEN INC | -- | $8,143.20 | 1,566 | BMTX3D7 |
| 0.01% | MXCT | MAXCYTE INC | -- | $7,736.80 | 5,090 | BKMQF66 |
| 0.01% | CDXS | CODEXIS INC | -- | $7,068.40 | 4,310 | B5LL2C2 |
| 0.01% | MRSN | MERSANA THERAPEUTICS INC | -- | $6,925.80 | 238 | BVPKH99 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $6,829.98 | 3,398 | BKX9NQ0 |
| 0.01% | ALEC | ALECTOR INC | -- | $6,717.87 | 4,833 | BJ4LDC4 |
| 0.01% | NKTX | NKARTA INC | -- | $5,968.16 | 3,391 | BK80YJ8 |
| 0.01% | FATE | FATE THERAPEUTICS INC | -- | $5,782.35 | 5,507 | BCZS820 |
| 0.01% | ARTV | ARTIVA BIOTHERAPEUTICS INC | -- | $5,421.90 | 1,166 | BMF1LJ7 |
| 0.01% | PYXS | PYXIS ONCOLOGY INC | -- | $5,122.53 | 2,961 | BLBR8D5 |
| 0.01% | MGNX | MACROGENICS INC | -- | $4,738.26 | 3,018 | BFDV8K0 |
| -- | BMEA | BIOMEA FUSION INC | -- | $3,835.35 | 2,841 | BNKF6N0 |
| -- | -- | SUTRO BIOPHARMA INC COMMON STOCK USD 0.001 | -- | $3,616.65 | 405 | -- |
| -- | TVGN | TEVOGEN BIO HOLDINGS INC | -- | $3,575.53 | 9,392 | BPG5P75 |
| -- | PLRX | PLIANT THERAPEUTICS INC | -- | $3,546.51 | 2,931 | BMDWW66 |
| -- | ACRV | ACRIVON THERAPEUTICS INC | -- | $3,394.52 | 1,502 | BP2TPK4 |
| -- | TCRX | TSCAN THERAPEUTICS INC | -- | $2,332.16 | 2,505 | BNLYBJ7 |
| -- | OKUR | ONKURE THERAPEUTICS INC-A | -- | $1,906.43 | 613 | BT7KGT6 |
| -- | QTTB | Q32 BIO INC | -- | $1,763.46 | 582 | BS2FKQ4 |
| -- | APLT | APPLIED THERAPEUTICS INC | -- | $849.87 | 6,876 | BJL38Z1 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 34.60% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 28,058,522 | -- | 5,008 | -- |
| 30.72% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 24,909,782 | -- | 4,446 | -- |
| 26.30% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 21,324,028 | -- | 3,806 | -- |
| 17.16% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 13,917,206 | -- | 2,484 | -- |
| 15.89% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 12,880,699 | -- | 2,299 | -- |
| 4.37% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,546,534 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $23,268,982.80 | 23,268,983 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
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