BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 11/30/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 16.90% | 51.72% | 95.62% | 66.67% | 42.59% | 11.36% | 1.61% | 2.01% | 16.86% | 04/07/2010 |
| BIB Market Price | 17.00% | 51.90% | 95.85% | 66.74% | 42.98% | 11.47% | 1.66% | 2.03% | 16.87% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/11/2025- NAV $80.70
- NAV Change $+1.26
- Market Price $80.67
- Market Price Change $+1.23
- Trading Volume (M) 11,377
- 30-Day Median Bid Ask Spread 0.26%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/11/2025- NAV $80.70
- NAV Change $+1.26
- Market Price $80.67
- Market Price Change $+1.23
- Trading Volume (M) 11,377
- 30-Day Median Bid Ask Spread 0.26%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 12/11/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.32% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $4,506,122.65 | 10,105 | 2931034 |
| 5.14% | AMGN | AMGEN INC | -- | $4,358,579.54 | 13,733 | 2023607 |
| 5.09% | GILD | GILEAD SCIENCES INC | -- | $4,309,269.75 | 34,975 | 2369174 |
| 4.35% | REGN | REGENERON PHARMACEUTICALS | -- | $3,683,964.40 | 4,933 | 2730190 |
| 3.02% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,561,194.41 | 6,207 | B00FWN1 |
| 2.63% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $2,232,510.54 | 24,726 | 2989044 |
| 2.33% | INSM | INSMED INC | -- | $1,970,166.84 | 10,091 | 2614487 |
| 1.53% | ARGX | ARGENX SE - ADR | -- | $1,300,434.38 | 1,462 | BDVLM39 |
| 1.42% | BIIB | BIOGEN INC | -- | $1,207,500.00 | 7,000 | 2455965 |
| 1.24% | UTHR | UNITED THERAPEUTICS CORP | -- | $1,054,693.09 | 2,159 | 2430412 |
| 1.18% | ILMN | ILLUMINA INC | -- | $1,001,333.16 | 7,339 | 2613990 |
| 1.06% | INCY | INCYTE CORP | -- | $896,036.40 | 9,324 | 2471950 |
| 0.95% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $801,077.21 | 20,641 | BMVP7Y0 |
| 0.90% | MEDP | MEDPACE HOLDINGS INC | -- | $759,207.15 | 1,341 | BDCBC61 |
| 0.86% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $732,896.00 | 4,736 | 2623911 |
| 0.83% | RVMD | REVOLUTION MEDICINES INC | -- | $700,701.75 | 8,925 | BL71K91 |
| 0.82% | ROIV | ROIVANT SCIENCES LTD | -- | $695,790.70 | 32,605 | BMW4NZ9 |
| 0.80% | BBIO | BRIDGEBIO PHARMA INC | -- | $676,065.32 | 9,128 | BK1KWG8 |
| 0.76% | VTRS | VIATRIS INC | -- | $645,168.94 | 55,666 | BMWS3X9 |
| 0.75% | SMMT | SUMMIT THERAPEUTICS INC | -- | $638,069.32 | 35,468 | BMTVQS7 |
| 0.74% | SNY | SANOFI-ADR | -- | $625,945.46 | 12,811 | 2964557 |
| 0.72% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $610,514.80 | 2,905 | BV9G6B8 |
| 0.72% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $607,895.12 | 1,064 | BD59BS7 |
| 0.71% | GH | GUARDANT HEALTH INC | -- | $603,616.52 | 5,954 | BFXC911 |
| 0.71% | IONS | IONIS PHARMACEUTICALS INC | -- | $602,255.40 | 7,610 | BDJ0LS6 |
| 0.70% | TEM | TEMPUS AI INC | -- | $594,942.30 | 8,055 | BSLSJJ0 |
| 0.65% | MRNA | MODERNA INC | -- | $550,436.51 | 18,577 | BGSXTS3 |
| 0.63% | EXEL | EXELIXIS INC | -- | $531,985.67 | 12,853 | 2576941 |
| 0.61% | ONC | BEONE MEDICINES LTD-ADR | -- | $514,948.20 | 1,605 | BYYWPW6 |
| 0.57% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $486,077.27 | 9,173 | 2437071 |
| 0.56% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $477,521.44 | 2,896 | B4Q5ZN4 |
| 0.55% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $467,482.82 | 6,601 | BYQBFJ8 |
| 0.54% | BNTX | BIONTECH SE-ADR | -- | $461,088.00 | 4,803 | BK6H543 |
| 0.52% | RNA | AVIDITY BIOSCIENCES INC | -- | $439,838.80 | 6,143 | BMWHPY1 |
| 0.44% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $373,208.26 | 3,173 | BF2YWG4 |
| 0.42% | AXSM | AXSOME THERAPEUTICS INC | -- | $354,471.25 | 2,383 | BYZR4X4 |
| 0.41% | CYTK | CYTOKINETICS INC | -- | $347,179.01 | 5,713 | BBBSBJ5 |
| 0.41% | HALO | HALOZYME THERAPEUTICS INC | -- | $345,711.50 | 5,585 | 2975098 |
| 0.40% | KRYS | KRYSTAL BIOTECH INC | -- | $341,043.05 | 1,382 | BD6JX35 |
| 0.40% | NUVL | NUVALENT INC-A | -- | $337,111.53 | 3,183 | BMVBZD3 |
| 0.35% | KYMR | KYMERA THERAPEUTICS INC | -- | $299,783.34 | 3,414 | BMPRZV5 |
| 0.34% | PTCT | PTC THERAPEUTICS INC | -- | $286,143.92 | 3,793 | B17VCN9 |
| 0.33% | PCVX | VAXCYTE INC | -- | $276,413.41 | 6,199 | BKPVGH6 |
| 0.32% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $273,982.50 | 2,970 | BDCBCD8 |
| 0.32% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $268,616.40 | 1,005 | BQ721R4 |
| 0.32% | COGT | COGENT BIOSCIENCES INC | -- | $267,066.80 | 6,670 | BLR6XK8 |
| 0.30% | CRSP | CRISPR THERAPEUTICS AG | -- | $252,284.87 | 4,343 | BDHF4K6 |
| 0.27% | ADMA | ADMA BIOLOGICS INC | -- | $232,209.72 | 11,394 | B9NSBM2 |
| 0.27% | ALKS | ALKERMES PLC | -- | $229,917.94 | 7,882 | B3P6D26 |
| 0.26% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $221,747.07 | 4,497 | BDD19F8 |
| 0.25% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $214,949.70 | 4,590 | BFZQ0L8 |
| 0.25% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $214,907.40 | 8,055 | 2713317 |
| 0.25% | INDV | INDIVIOR PLC | -- | $213,201.03 | 5,957 | BP0BQQ5 |
| 0.24% | IMVT | IMMUNOVANT INC | -- | $206,493.63 | 8,323 | BJRFSB7 |
| 0.23% | TERN | TERNS PHARMACEUTICALS INC | -- | $196,742.02 | 4,178 | BMDJ0C9 |
| 0.23% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $194,522.26 | 5,378 | BP8JSP4 |
| 0.23% | ACLX | ARCELLX INC | -- | $192,483.12 | 2,648 | BPCJ1Q2 |
| 0.23% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $191,394.72 | 2,838 | BQS9486 |
| 0.22% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $183,701.00 | 14,996 | BFNF1D6 |
| 0.20% | LGND | LIGAND PHARMACEUTICALS | -- | $171,409.68 | 936 | 2501578 |
| 0.20% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $168,715.75 | 5,725 | BKX9VD3 |
| 0.20% | APGE | APOGEE THERAPEUTICS INC | -- | $168,519.06 | 2,202 | BM9HHL5 |
| 0.20% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $166,556.20 | 4,601 | BJ62Z18 |
| 0.19% | TARS | TARSUS PHARMACEUTICALS INC | -- | $164,707.20 | 2,016 | BMH5RL1 |
| 0.19% | GRAL | GRAIL INC | -- | $163,598.26 | 1,721 | BSLSSX7 |
| 0.19% | XENE | XENON PHARMACEUTICALS INC | -- | $160,756.12 | 3,682 | BRJ3GY4 |
| 0.19% | VCYT | VERACYTE INC | -- | $158,578.32 | 3,756 | BFTWZY0 |
| 0.19% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $157,662.28 | 2,399 | BJDX8Y8 |
| 0.18% | IRON | DISC MEDICINE INC | -- | $155,376.00 | 1,660 | BMGJZJ8 |
| 0.18% | CGON | CG ONCOLOGY INC | -- | $151,502.01 | 3,641 | BRBCSP4 |
| 0.18% | APLS | APELLIS PHARMACEUTICALS INC | -- | $150,538.95 | 6,030 | BYTQ6X1 |
| 0.18% | TVTX | TRAVERE THERAPEUTICS INC | -- | $149,002.56 | 4,256 | BLFGJD5 |
| 0.17% | FOLD | AMICUS THERAPEUTICS INC | -- | $145,698.30 | 14,717 | B19FQ48 |
| 0.17% | IDYA | IDEAYA BIOSCIENCES INC | -- | $140,448.60 | 4,185 | BK0VHF6 |
| 0.17% | VERA | VERA THERAPEUTICS INC | -- | $140,222.94 | 3,047 | BL55460 |
| 0.16% | BEAM | BEAM THERAPEUTICS INC | -- | $132,873.30 | 4,830 | BK6L288 |
| 0.16% | DYN | DYNE THERAPEUTICS INC | -- | $131,920.06 | 6,793 | BN15WD1 |
| 0.15% | WVE | WAVE LIFE SCIENCES LTD | -- | $127,266.50 | 7,598 | BYZG9R0 |
| 0.15% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $124,511.58 | 4,581 | BLB0YQ9 |
| 0.15% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $124,507.27 | 2,677 | B72ZBG4 |
| 0.14% | OCUL | OCULAR THERAPEUTIX INC | -- | $121,878.36 | 8,308 | BNZB1X8 |
| 0.14% | DNLI | DENALI THERAPEUTICS INC | -- | $121,259.97 | 6,981 | BD2B4V0 |
| 0.14% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $117,852.90 | 5,030 | BKY5JZ8 |
| 0.13% | MLYS | MINERALYS THERAPEUTICS INC | -- | $114,098.25 | 3,165 | BP9N0G0 |
| 0.13% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $112,118.82 | 7,271 | BJ5FZ74 |
| 0.13% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $108,753.73 | 2,747 | BKSGZN7 |
| 0.12% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $103,487.66 | 3,277 | BMZ4LN0 |
| 0.12% | SRPT | SAREPTA THERAPEUTICS INC | -- | $101,463.75 | 4,665 | B8DPDT7 |
| 0.12% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $99,678.76 | 6,277 | BFWLC09 |
| 0.12% | AVDL | AVADEL PHARMACEUTICALS | -- | $99,164.04 | 4,636 | BDGMC59 |
| 0.12% | SYRE | SPYRE THERAPEUTICS INC | -- | $99,094.24 | 2,884 | BQBBDY8 |
| 0.12% | IBRX | IMMUNITYBIO INC | -- | $98,841.27 | 45,133 | BNSP0B8 |
| 0.11% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $93,445.74 | 20,403 | BM9FJ13 |
| 0.11% | TWST | TWIST BIOSCIENCE CORP | -- | $92,601.96 | 2,883 | BGKG6G7 |
| 0.11% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $92,500.20 | 4,020 | BMX9K07 |
| 0.11% | TXG | 10X GENOMICS INC-CLASS A | -- | $90,358.02 | 5,463 | BKS3RS7 |
| 0.11% | HROW | HARROW INC | -- | $90,293.70 | 1,767 | BHNDW86 |
| 0.11% | VCEL | VERICEL CORP | -- | $90,072.51 | 2,409 | BSBMN89 |
| 0.11% | ZYME | ZYMEWORKS INC | -- | $89,509.66 | 3,589 | BPCQZY9 |
| 0.10% | STOK | STOKE THERAPEUTICS INC | -- | $86,563.44 | 2,616 | BJQ05Z6 |
| 0.10% | ALVO | ALVOTECH SA | -- | $85,939.50 | 14,946 | BPNTJ34 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $85,136.76 | 2,076 | BRXB0C0 |
| 0.10% | MNKD | MANNKIND CORP | -- | $85,116.50 | 14,650 | BF081J4 |
| 0.10% | ANIP | ANI PHARMACEUTICALS INC | -- | $85,086.68 | 1,036 | BCDWBX6 |
| 0.10% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $83,946.33 | 4,113 | BN7Q7R7 |
| 0.09% | TRVI | TREVI THERAPEUTICS INC | -- | $76,570.38 | 5,814 | BJH9ZN0 |
| 0.09% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $76,174.04 | 2,774 | BCBVTX1 |
| 0.09% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $75,974.34 | 10,023 | 2100362 |
| 0.09% | TSHA | TAYSHA GENE THERAPIES INC | -- | $75,024.00 | 13,025 | BNC1BX1 |
| 0.09% | NVCR | NOVOCURE LTD | -- | $72,917.08 | 5,338 | BYSS4X4 |
| 0.09% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $72,733.44 | 1,504 | BX7RSN3 |
| 0.08% | NRIX | NURIX THERAPEUTICS INC | -- | $69,605.50 | 3,650 | BMVLGP2 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $68,449.60 | 1,912 | BLCD809 |
| 0.08% | ARDX | ARDELYX INC | -- | $67,885.40 | 11,506 | BN89V40 |
| 0.08% | FTRE | FORTREA HOLDINGS INC | -- | $67,409.25 | 4,335 | BRXYZ57 |
| 0.08% | GMAB | GENMAB A/S -SP ADR | -- | $64,664.60 | 2,002 | BBC9WC7 |
| 0.08% | RLAY | RELAY THERAPEUTICS INC | -- | $64,127.28 | 8,232 | BN2R582 |
| 0.07% | INVA | INNOVIVA INC | -- | $62,045.58 | 3,009 | BDDXF67 |
| 0.07% | SANA | SANA BIOTECHNOLOGY INC | -- | $61,760.00 | 12,352 | BMFJJ97 |
| 0.07% | ANAB | ANAPTYSBIO INC | -- | $61,207.86 | 1,337 | BDRW1L7 |
| 0.07% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $60,805.14 | 5,599 | BRJZSK0 |
| 0.07% | XNCR | XENCOR INC | -- | $58,089.30 | 3,405 | BGCYWN8 |
| 0.07% | TYRA | TYRA BIOSCIENCES INC | -- | $58,051.45 | 2,545 | BMVNDH9 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $57,498.00 | 2,220 | BNFWZS4 |
| 0.07% | SVRA | SAVARA INC | -- | $57,268.88 | 8,252 | BYXGN81 |
| 0.07% | INBX | INHIBRX BIOSCIENCES INC | -- | $56,889.32 | 692 | BNSP8K3 |
| 0.07% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $55,638.99 | 4,257 | BPCK358 |
| 0.07% | PCRX | PACIRA BIOSCIENCES INC | -- | $55,190.85 | 2,145 | B3X26D8 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $54,047.10 | 7,710 | BLR7H87 |
| 0.06% | ORKA | ORUKA THERAPEUTICS INC | -- | $54,015.48 | 1,788 | BKVF0J2 |
| 0.06% | ALMS | ALUMIS INC | -- | $53,707.86 | 4,626 | BPLQG36 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $53,362.32 | 14,268 | BL53SR3 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $53,357.00 | 5,825 | B8K7T65 |
| 0.06% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $53,081.56 | 2,828 | BMFD115 |
| 0.06% | EYPT | EYEPOINT PHARMACEUTICALS INC | -- | $52,985.10 | 3,291 | BMGS7L1 |
| 0.06% | SPRY | ARS PHARMACEUTICALS INC | -- | $52,947.18 | 4,719 | BMCR7V2 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $52,588.45 | 1,385 | BKLCWZ3 |
| 0.06% | NVAX | NOVAVAX INC | -- | $51,880.95 | 7,755 | BJDQXG4 |
| 0.06% | QURE | UNIQURE NV | -- | $51,745.00 | 2,620 | BJFSR88 |
| 0.06% | PGEN | PRECIGEN INC | -- | $51,501.74 | 14,227 | BKM5C84 |
| 0.06% | RAPP | RAPPORT THERAPEUTICS INC | -- | $50,163.54 | 1,743 | BR3T9B6 |
| 0.06% | URGN | UROGEN PHARMA LTD | -- | $49,393.24 | 2,209 | BZ7PJQ1 |
| 0.06% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $49,348.59 | 3,387 | BJLKVS6 |
| 0.06% | NTLA | INTELLIA THERAPEUTICS INC | -- | $48,943.75 | 5,125 | BYZM6C2 |
| 0.06% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $48,835.44 | 2,949 | BP7KZP7 |
| 0.06% | TNGX | TANGO THERAPEUTICS INC | -- | $48,339.20 | 5,312 | BP2P6L0 |
| 0.06% | AVBP | ARRIVENT BIOPHARMA INC | -- | $47,107.84 | 1,937 | BMGTLY5 |
| 0.05% | ERAS | ERASCA INC | -- | $45,778.72 | 13,544 | BNLYBF3 |
| 0.05% | MNMD | MIND MEDICINE MINDMED INC | -- | $45,739.47 | 3,633 | BPQYY97 |
| 0.05% | ORIC | ORIC PHARMACEUTICALS INC | -- | $44,932.53 | 4,637 | BKVDFF7 |
| 0.05% | ARVN | ARVINAS INC | -- | $44,095.56 | 3,508 | BDZ30Q0 |
| 0.05% | JANX | JANUX THERAPEUTICS INC | -- | $44,067.84 | 2,869 | BMFX8Y7 |
| 0.05% | VIR | VIR BIOTECHNOLOGY INC | -- | $43,976.79 | 6,633 | BK4PZ38 |
| 0.05% | KURA | KURA ONCOLOGY INC | -- | $43,346.24 | 4,144 | BYZD465 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $42,744.51 | 9,153 | BZ0QMB7 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $42,520.40 | 2,405 | BMNDK09 |
| 0.05% | GERN | GERON CORP | -- | $42,343.57 | 30,463 | 2370381 |
| 0.05% | KROS | KEROS THERAPEUTICS INC | -- | $42,056.91 | 1,939 | BM7V485 |
| 0.05% | CRMD | CORMEDIX INC | -- | $41,841.36 | 3,564 | BJ0LT31 |
| 0.05% | MESO | MESOBLAST LTD- SPON ADR | -- | $41,473.60 | 2,254 | BQS7491 |
| 0.05% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $41,182.22 | 4,891 | BLB0YH0 |
| 0.05% | ZLAB | ZAI LAB LTD-ADR | -- | $40,683.06 | 2,283 | BD9GVY0 |
| 0.05% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $40,661.40 | 2,406 | BD06CS0 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $39,618.72 | 972 | BL95N25 |
| 0.05% | PSNL | PERSONALIS INC | -- | $39,291.52 | 4,234 | BJQ0608 |
| 0.05% | ESPR | ESPERION THERAPEUTICS INC | -- | $39,278.16 | 9,627 | BBNBTD2 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $38,873.25 | 17,277 | BF0DMK7 |
| 0.04% | REPL | REPLIMUNE GROUP INC | -- | $36,785.49 | 3,727 | BDDVW37 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $36,504.32 | 5,776 | BYVQJ96 |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $35,994.80 | 856 | BQD3J33 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $35,650.23 | 8,349 | BPBJFM7 |
| 0.04% | CGEM | CULLINAN THERAPEUTICS INC | -- | $34,923.98 | 2,821 | BM90J52 |
| 0.04% | ATXS | ASTRIA THERAPEUTICS INC | -- | $34,792.45 | 2,695 | BMYRFN8 |
| 0.04% | OMER | OMEROS CORP | -- | $34,406.91 | 3,249 | B4NB858 |
| 0.04% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $33,493.52 | 3,841 | BFYQFJ2 |
| 0.04% | LENZ | LENZ THERAPEUTICS INC | -- | $33,369.00 | 1,362 | BQV0J03 |
| 0.04% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $31,122.14 | 14,342 | B4N8MH9 |
| 0.04% | RGNX | REGENXBIO INC | -- | $30,994.20 | 2,412 | BZ0G875 |
| 0.04% | LYEL | LYELL IMMUNOPHARMA INC | -- | $30,636.97 | 917 | BTNMG41 |
| 0.04% | CMPS | COMPASS PATHWAYS PLC | -- | $30,390.26 | 4,379 | BMC3HS7 |
| 0.04% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $29,904.00 | 3,560 | BYP80F1 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $28,542.08 | 7,756 | B3MZ6K5 |
| 0.03% | ABSI | ABSCI CORP | -- | $27,413.76 | 7,139 | BN94K69 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $26,548.10 | 2,570 | B91XRN2 |
| 0.03% | ANNX | ANNEXON INC | -- | $26,444.88 | 5,247 | BMVV9R5 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $25,628.68 | 6,908 | BMCWKZ2 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $25,264.40 | 2,578 | BQ6C357 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $25,123.56 | 2,719 | BMFK3H6 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $24,351.60 | 2,230 | BKLXFX5 |
| 0.03% | LXRX | LEXICON PHARMACEUTICALS INC | -- | $22,903.32 | 17,351 | BWFZX59 |
| 0.03% | ALT | ALTIMMUNE INC | -- | $22,502.76 | 4,214 | BFY7DC4 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $22,485.20 | 2,680 | BLFBZ32 |
| 0.03% | SIGA | SIGA TECHNOLOGIES INC | -- | $22,291.88 | 3,419 | 2107437 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $22,277.88 | 684 | B292NQ7 |
| 0.03% | SLDB | SOLID BIOSCIENCES INC | -- | $21,824.66 | 3,718 | BQHN6C7 |
| 0.03% | EOLS | EVOLUS INC | -- | $21,344.99 | 3,089 | BDRJH21 |
| 0.02% | HCM | HUTCHMED CHINA-ADR | -- | $20,141.60 | 1,481 | BYXV9H7 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $19,630.96 | 1,816 | BP81RK8 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $19,308.66 | 2,966 | BP81R42 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $18,618.60 | 2,821 | B12W3P6 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $17,774.40 | 5,152 | BDFKQ07 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $17,386.71 | 893 | BPBPCG8 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $17,263.40 | 2,065 | BSMLR16 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $16,855.11 | 4,101 | BYTYP72 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $16,429.74 | 4,087 | BMXNGZ6 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $16,420.70 | 10,594 | BFZNYB7 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $16,398.01 | 2,207 | BKDQKM6 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $16,005.24 | 7,732 | BN4JN37 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $15,436.68 | 4,794 | BZC0D70 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $15,227.43 | 9,577 | BFMLGR4 |
| 0.02% | NGNE | NEUROGENE INC | -- | $14,478.06 | 681 | BS2F741 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $14,438.48 | 2,242 | BL5B6Z1 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $14,436.94 | 1,021 | B9L5200 |
| 0.02% | AMRN | AMARIN CORP PLC -ADR | -- | $13,944.24 | 963 | BN72KB0 |
| 0.02% | PYXS | PYXIS ONCOLOGY INC | -- | $13,058.01 | 2,961 | BLBR8D5 |
| 0.01% | OABI | OMNIAB INC | -- | $12,655.44 | 5,859 | BN13S71 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $12,493.95 | 2,555 | BP7L561 |
| 0.01% | FHTX | FOGHORN THERAPEUTICS INC | -- | $12,091.52 | 2,699 | BMF7DT9 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $12,086.91 | 3,789 | BLN9Z50 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $11,677.68 | 2,648 | BY7RB53 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $10,990.08 | 4,293 | BZ8FPH3 |
| 0.01% | RNAC | CARTESIAN THERAPEUTICS INC | -- | $10,494.90 | 1,242 | BQB9HM8 |
| 0.01% | HUMA | HUMACYTE INC | -- | $9,906.22 | 7,562 | BMYTJP4 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $9,753.44 | 1,297 | BKC9SX3 |
| 0.01% | PEPG | PEPGEN INC | -- | $8,988.84 | 1,566 | BMTX3D7 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $8,630.92 | 3,398 | BKX9NQ0 |
| 0.01% | MXCT | MAXCYTE INC | -- | $8,144.00 | 5,090 | BKMQF66 |
| 0.01% | CLYM | CLIMB BIO INC | -- | $7,442.80 | 3,236 | BMW5LX6 |
| 0.01% | CDXS | CODEXIS INC | -- | $7,370.10 | 4,310 | B5LL2C2 |
| 0.01% | ALEC | ALECTOR INC | -- | $7,056.18 | 4,833 | BJ4LDC4 |
| 0.01% | MRSN | MERSANA THERAPEUTICS INC | -- | $6,718.74 | 238 | BVPKH99 |
| 0.01% | NKTX | NKARTA INC | -- | $6,341.17 | 3,391 | BK80YJ8 |
| 0.01% | FATE | FATE THERAPEUTICS INC | -- | $6,112.77 | 5,507 | BCZS820 |
| 0.01% | BMEA | BIOMEA FUSION INC | -- | $4,318.32 | 2,841 | BNKF6N0 |
| 0.01% | MGNX | MACROGENICS INC | -- | $4,255.38 | 3,018 | BFDV8K0 |
| -- | TVGN | TEVOGEN BIO HOLDINGS INC | -- | $4,038.56 | 9,392 | BPG5P75 |
| -- | -- | SUTRO BIOPHARMA INC COMMON STOCK USD 0.001 | -- | $3,973.05 | 405 | -- |
| -- | ACRV | ACRIVON THERAPEUTICS INC | -- | $3,920.22 | 1,502 | BP2TPK4 |
| -- | PLRX | PLIANT THERAPEUTICS INC | -- | $3,868.92 | 2,931 | BMDWW66 |
| -- | ARTV | ARTIVA BIOTHERAPEUTICS INC | -- | $3,661.24 | 1,166 | BMF1LJ7 |
| -- | TCRX | TSCAN THERAPEUTICS INC | -- | $2,680.35 | 2,505 | BNLYBJ7 |
| -- | OKUR | ONKURE THERAPEUTICS INC-A | -- | $1,979.99 | 613 | BT7KGT6 |
| -- | QTTB | Q32 BIO INC | -- | $1,850.76 | 582 | BS2FKQ4 |
| -- | APLT | APPLIED THERAPEUTICS INC | -- | $1,491.40 | 6,876 | BJL38Z1 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| 33.85% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 28,679,414 | -- | 5,008 | -- |
| 33.51% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 28,393,078 | -- | 4,958 | -- |
| 26.34% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 22,317,028 | -- | 3,897 | -- |
| 16.79% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,225,172 | -- | 2,484 | -- |
| 15.54% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 13,165,729 | -- | 2,299 | -- |
| 4.28% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,625,014 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $25,644,157.90 | 25,644,158 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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