BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 1/31/2026
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 4.27% | 16.53% | 65.39% | 4.27% | 51.38% | 11.58% | -2.47% | 6.91% | 16.64% | 04/07/2010 |
| BIB Market Price | 4.19% | 16.41% | 65.44% | 4.19% | 51.07% | 11.50% | -2.49% | 6.94% | 16.64% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 2/09/2026- NAV $86.31
- NAV Change $-0.31
- Market Price $86.28
- Market Price Change $-0.38
- Trading Volume (M) 10,332
- 30-Day Median Bid Ask Spread 0.28%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 2/09/2026- NAV $86.31
- NAV Change $-0.31
- Market Price $86.28
- Market Price Change $-0.38
- Trading Volume (M) 10,332
- 30-Day Median Bid Ask Spread 0.28%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 12/31/2025
Holdings
as of 2/09/2026
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 6.77% | GILD | GILEAD SCIENCES INC | -- | $6,137,427.84 | 40,463 | 2369174 |
| 6.11% | AMGN | AMGEN INC | -- | $5,539,210.98 | 14,739 | 2023607 |
| 6.10% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,529,426.41 | 11,743 | 2931034 |
| 4.16% | REGN | REGENERON PHARMACEUTICALS | -- | $3,773,434.08 | 4,836 | 2730190 |
| 2.18% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $1,979,520.00 | 6,186 | B00FWN1 |
| 1.65% | INSM | INSMED INC | -- | $1,493,306.44 | 9,986 | 2614487 |
| 1.47% | BIIB | BIOGEN INC | -- | $1,331,280.89 | 6,869 | 2455965 |
| 1.25% | ARGX | ARGENX SE - ADR | -- | $1,128,891.12 | 1,363 | BDVLM39 |
| 1.11% | INCY | INCYTE CORP | -- | $1,002,203.76 | 9,192 | 2471950 |
| 1.05% | UTHR | UNITED THERAPEUTICS CORP | -- | $953,809.92 | 2,016 | 2430412 |
| 0.99% | ROIV | ROIVANT SCIENCES LTD | -- | $901,045.88 | 32,564 | BMW4NZ9 |
| 0.97% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $881,220.25 | 20,005 | BMVP7Y0 |
| 0.97% | RVMD | REVOLUTION MEDICINES INC | -- | $875,690.48 | 9,052 | BL71K91 |
| 0.93% | VTRS | VIATRIS INC | -- | $839,119.68 | 53,928 | BMWS3X9 |
| 0.93% | ILMN | ILLUMINA INC | -- | $838,806.50 | 7,154 | 2613990 |
| 0.85% | MRNA | MODERNA INC | -- | $767,349.40 | 18,292 | BGSXTS3 |
| 0.77% | MEDP | MEDPACE HOLDINGS INC | -- | $699,531.65 | 1,319 | BDCBC61 |
| 0.72% | BBIO | BRIDGEBIO PHARMA INC | -- | $652,200.38 | 9,022 | BK1KWG8 |
| 0.72% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $651,466.08 | 4,668 | 2623911 |
| 0.71% | IONS | IONIS PHARMACEUTICALS INC | -- | $643,047.36 | 7,584 | BDJ0LS6 |
| 0.70% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $638,336.25 | 2,875 | BV9G6B8 |
| 0.70% | GH | GUARDANT HEALTH INC | -- | $638,149.72 | 6,058 | BFXC911 |
| 0.66% | SNY | SANOFI-ADR | -- | $598,065.30 | 12,390 | 2964557 |
| 0.61% | EXEL | EXELIXIS INC | -- | $551,748.30 | 12,554 | 2576941 |
| 0.58% | BNTX | BIONTECH SE-ADR | -- | $522,349.56 | 4,734 | BK6H543 |
| 0.58% | SMMT | SUMMIT THERAPEUTICS INC | -- | $521,794.32 | 34,856 | BMTVQS7 |
| 0.57% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $520,000.95 | 8,995 | 2437071 |
| 0.57% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $519,020.38 | 1,063 | BD59BS7 |
| 0.57% | RNA | AVIDITY BIOSCIENCES INC | -- | $514,238.95 | 7,055 | BMWHPY1 |
| 0.57% | ONC | BEONE MEDICINES LTD-ADR | -- | $514,204.90 | 1,474 | BYYWPW6 |
| 0.52% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $469,425.00 | 2,845 | B4Q5ZN4 |
| 0.51% | TEM | TEMPUS AI INC | -- | $462,329.28 | 8,094 | BSLSJJ0 |
| 0.49% | HALO | HALOZYME THERAPEUTICS INC | -- | $443,122.88 | 5,506 | 2975098 |
| 0.48% | AXSM | AXSOME THERAPEUTICS INC | -- | $432,399.20 | 2,360 | BYZR4X4 |
| 0.44% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $398,327.76 | 6,359 | BYQBFJ8 |
| 0.41% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $374,181.34 | 1,171 | BQ721R4 |
| 0.41% | KRYS | KRYSTAL BIOTECH INC | -- | $370,204.38 | 1,358 | BD6JX35 |
| 0.40% | CYTK | CYTOKINETICS INC | -- | $362,736.00 | 5,725 | BBBSBJ5 |
| 0.38% | NUVL | NUVALENT INC-A | -- | $348,312.18 | 3,382 | BMVBZD3 |
| 0.38% | PCVX | VAXCYTE INC | -- | $340,588.53 | 6,129 | BKPVGH6 |
| 0.37% | ABVX | ABIVAX SA-ADR | -- | $331,071.92 | 2,764 | BLC89B2 |
| 0.36% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $324,906.25 | 3,125 | BF2YWG4 |
| 0.35% | IBRX | IMMUNITYBIO INC | -- | $319,597.74 | 46,118 | BNSP0B8 |
| 0.33% | CAI | CARIS LIFE SCIENCES INC | -- | $294,737.41 | 13,211 | BT18HP9 |
| 0.31% | PTCT | PTC THERAPEUTICS INC | -- | $278,767.44 | 3,759 | B17VCN9 |
| 0.30% | COGT | COGENT BIOSCIENCES INC | -- | $272,746.65 | 7,187 | BLR6XK8 |
| 0.30% | ALKS | ALKERMES PLC | -- | $269,348.04 | 7,731 | B3P6D26 |
| 0.29% | KYMR | KYMERA THERAPEUTICS INC | -- | $266,218.38 | 3,369 | BMPRZV5 |
| 0.27% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $246,971.97 | 3,129 | BQS9486 |
| 0.27% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $243,877.64 | 2,927 | BDCBCD8 |
| 0.27% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $241,899.24 | 2,406 | BJDX8Y8 |
| 0.25% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $228,531.60 | 4,776 | BFZQ0L8 |
| 0.25% | IMVT | IMMUNOVANT INC | -- | $225,610.43 | 8,207 | BJRFSB7 |
| 0.24% | CRSP | CRISPR THERAPEUTICS AG | -- | $221,761.40 | 4,462 | BDHF4K6 |
| 0.24% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $213,719.88 | 14,719 | BFNF1D6 |
| 0.23% | FOLD | AMICUS THERAPEUTICS INC | -- | $206,577.80 | 14,446 | B19FQ48 |
| 0.23% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $204,422.43 | 4,443 | BDD19F8 |
| 0.22% | INDV | INDIVIOR PHARMACEUTICALS INC | -- | $197,877.84 | 5,844 | BTZRLN8 |
| 0.21% | CGON | CG ONCOLOGY INC | -- | $192,929.16 | 3,777 | BRBCSP4 |
| 0.21% | ACLX | ARCELLX INC | -- | $186,241.60 | 2,707 | BPCJ1Q2 |
| 0.21% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $185,815.00 | 5,309 | BP8JSP4 |
| 0.20% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $183,925.62 | 7,921 | 2713317 |
| 0.20% | GRAL | GRAIL INC | -- | $183,230.00 | 1,825 | BSLSSX7 |
| 0.20% | ADMA | ADMA BIOLOGICS INC | -- | $182,427.28 | 11,144 | B9NSBM2 |
| 0.19% | LGND | LIGAND PHARMACEUTICALS | -- | $172,349.46 | 922 | 2501578 |
| 0.18% | TERN | TERNS PHARMACEUTICALS INC | -- | $160,199.64 | 4,218 | BMDJ0C9 |
| 0.18% | ERAS | ERASCA INC | -- | $159,540.84 | 13,284 | BNLYBF3 |
| 0.18% | APGE | APOGEE THERAPEUTICS INC | -- | $159,487.71 | 2,567 | BM9HHL5 |
| 0.17% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $154,156.80 | 5,735 | BKX9VD3 |
| 0.17% | XENE | XENON PHARMACEUTICALS INC | -- | $153,511.74 | 3,618 | BRJ3GY4 |
| 0.17% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $149,949.25 | 4,957 | BKY5JZ8 |
| 0.16% | DNLI | DENALI THERAPEUTICS INC | -- | $143,108.28 | 6,867 | BD2B4V0 |
| 0.15% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $137,740.50 | 2,685 | B72ZBG4 |
| 0.15% | VCYT | VERACYTE INC | -- | $135,937.73 | 3,701 | BFTWZY0 |
| 0.15% | TWST | TWIST BIOSCIENCE CORP | -- | $135,906.61 | 2,863 | BGKG6G7 |
| 0.15% | APLS | APELLIS PHARMACEUTICALS INC | -- | $135,176.43 | 5,921 | BYTQ6X1 |
| 0.15% | IDYA | IDEAYA BIOSCIENCES INC | -- | $132,960.95 | 4,105 | BK0VHF6 |
| 0.14% | VERA | VERA THERAPEUTICS INC | -- | $131,155.35 | 2,991 | BL55460 |
| 0.14% | TARS | TARSUS PHARMACEUTICALS INC | -- | $130,214.00 | 1,988 | BMH5RL1 |
| 0.14% | IRON | DISC MEDICINE INC | -- | $130,018.72 | 1,768 | BMGJZJ8 |
| 0.14% | BEAM | BEAM THERAPEUTICS INC | -- | $129,607.28 | 4,751 | BK6L288 |
| 0.14% | TVTX | TRAVERE THERAPEUTICS INC | -- | $125,963.23 | 4,189 | BLFGJD5 |
| 0.14% | SYRE | SPYRE THERAPEUTICS INC | -- | $123,376.68 | 3,633 | BQBBDY8 |
| 0.13% | ALMS | ALUMIS INC | -- | $118,898.24 | 4,552 | BPLQG36 |
| 0.13% | MLYS | MINERALYS THERAPEUTICS INC | -- | $117,596.70 | 3,705 | BP9N0G0 |
| 0.13% | DYN | DYNE THERAPEUTICS INC | -- | $113,612.13 | 6,687 | BN15WD1 |
| 0.13% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $113,367.28 | 7,148 | BJ5FZ74 |
| 0.12% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $107,865.96 | 4,517 | BJ62Z18 |
| 0.12% | MAZE | MAZE THERAPEUTICS INC | -- | $107,490.63 | 2,253 | BSRK699 |
| 0.12% | WVE | WAVE LIFE SCIENCES LTD | -- | $107,049.77 | 7,831 | BYZG9R0 |
| 0.12% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $106,285.01 | 4,517 | BLB0YQ9 |
| 0.11% | TXG | 10X GENOMICS INC-CLASS A | -- | $101,117.16 | 5,454 | BKS3RS7 |
| 0.11% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $100,004.76 | 2,697 | BKSGZN7 |
| 0.11% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $95,818.50 | 24,075 | BM9FJ13 |
| 0.10% | OCUL | OCULAR THERAPEUTIX INC | -- | $94,064.25 | 9,975 | BNZB1X8 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $93,800.25 | 2,115 | BRXB0C0 |
| 0.10% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $91,890.85 | 3,683 | BMZ4LN0 |
| 0.10% | SRPT | SAREPTA THERAPEUTICS INC | -- | $89,828.86 | 4,906 | B8DPDT7 |
| 0.10% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $89,693.69 | 6,173 | BFWLC09 |
| 0.10% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $86,243.30 | 4,070 | BN7Q7R7 |
| 0.09% | STOK | STOKE THERAPEUTICS INC | -- | $85,573.25 | 2,675 | BJQ05Z6 |
| 0.09% | MNKD | MANNKIND CORP | -- | $84,973.98 | 14,378 | BF081J4 |
| 0.09% | ANIP | ANI PHARMACEUTICALS INC | -- | $84,517.68 | 1,052 | BCDWBX6 |
| 0.09% | GMAB | GENMAB A/S -SP ADR | -- | $84,491.19 | 2,737 | BBC9WC7 |
| 0.09% | VCEL | VERICEL CORP | -- | $83,921.92 | 2,368 | BSBMN89 |
| 0.09% | ARDX | ARDELYX INC | -- | $83,393.41 | 11,377 | BN89V40 |
| 0.09% | HROW | HARROW INC | -- | $82,295.64 | 1,734 | BHNDW86 |
| 0.09% | TNGX | TANGO THERAPEUTICS INC | -- | $81,284.34 | 6,306 | BP2P6L0 |
| 0.09% | PHVS | PHARVARIS NV | -- | $81,002.99 | 2,999 | BMZ2X38 |
| 0.09% | DFTX | DEFINIUM THERAPEUTICS INC | -- | $80,018.20 | 4,612 | BV2DHY6 |
| 0.09% | NRIX | NURIX THERAPEUTICS INC | -- | $79,305.66 | 4,746 | BMVLGP2 |
| 0.09% | ZYME | ZYMEWORKS INC | -- | $78,875.04 | 3,504 | BPCQZY9 |
| 0.09% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $78,034.32 | 2,779 | BMFD115 |
| 0.09% | MBX | MBX BIOSCIENCES INC | -- | $77,837.06 | 2,102 | BQXJKH2 |
| 0.08% | SION | SIONNA THERAPEUTICS INC | -- | $76,953.80 | 2,090 | BQKXDX4 |
| 0.08% | TYRA | TYRA BIOSCIENCES INC | -- | $76,219.50 | 2,499 | BMVNDH9 |
| 0.08% | QURE | UNIQURE NV | -- | $75,987.85 | 2,917 | BJFSR88 |
| 0.08% | INVA | INNOVIVA INC | -- | $75,726.63 | 3,501 | BDDXF67 |
| 0.08% | PGEN | PRECIGEN INC | -- | $75,545.52 | 16,567 | BKM5C84 |
| 0.08% | ORKA | ORUKA THERAPEUTICS INC | -- | $75,400.42 | 2,267 | BKVF0J2 |
| 0.08% | ALVO | ALVOTECH SA | -- | $75,331.84 | 14,656 | BPNTJ34 |
| 0.08% | RAPT | RAPT THERAPEUTICS INC | -- | $74,927.69 | 1,297 | BTJZB49 |
| 0.08% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $73,546.20 | 2,730 | BCBVTX1 |
| 0.08% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $73,119.24 | 5,142 | BPCK358 |
| 0.08% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $71,373.77 | 3,497 | BYP80F1 |
| 0.08% | RLAY | RELAY THERAPEUTICS INC | -- | $70,194.75 | 8,115 | BN2R582 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $68,494.40 | 1,480 | BX7RSN3 |
| 0.07% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $67,950.18 | 2,043 | BLCD809 |
| 0.07% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $67,762.98 | 3,942 | BMX9K07 |
| 0.07% | NTLA | INTELLIA THERAPEUTICS INC | -- | $67,733.27 | 5,423 | BYZM6C2 |
| 0.07% | ATAI | ATAIBECKLEY INC | -- | $66,914.68 | 17,005 | BWJDYK1 |
| 0.07% | TRVI | TREVI THERAPEUTICS INC | -- | $66,644.40 | 6,004 | BJH9ZN0 |
| 0.07% | NVAX | NOVAVAX INC | -- | $66,198.30 | 7,609 | BJDQXG4 |
| 0.07% | UPB | UPSTREAM BIO INC | -- | $66,083.60 | 2,530 | BRCFFK6 |
| 0.07% | ANAB | ANAPTYSBIO INC | -- | $64,735.20 | 1,296 | BDRW1L7 |
| 0.07% | FTRE | FORTREA HOLDINGS INC | -- | $64,370.88 | 4,326 | BRXYZ57 |
| 0.07% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $62,105.40 | 9,858 | 2100362 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $61,568.72 | 2,152 | BNFWZS4 |
| 0.07% | RAPP | RAPPORT THERAPEUTICS INC | -- | $60,888.96 | 2,232 | BR3T9B6 |
| 0.07% | KOD | KODIAK SCIENCES INC | -- | $60,361.20 | 2,484 | BFXC933 |
| 0.07% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $59,729.91 | 3,049 | BP7KZP7 |
| 0.07% | TSHA | TAYSHA GENE THERAPIES INC | -- | $59,123.25 | 12,825 | BNC1BX1 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $58,899.69 | 681 | BNSP8K3 |
| 0.06% | ZBIO | ZENAS BIOPHARMA INC | -- | $56,492.24 | 2,513 | BQB42H3 |
| 0.06% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $56,338.04 | 4,807 | BLB0YH0 |
| 0.06% | SEPN | SEPTERNA INC | -- | $55,732.64 | 2,096 | BQNKXX2 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $54,720.96 | 5,712 | B8K7T65 |
| 0.06% | EYPT | EYEPOINT INC | -- | $54,535.32 | 3,876 | BMGS7L1 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $54,072.24 | 7,769 | BLR7H87 |
| 0.06% | NVCR | NOVOCURE LTD | -- | $52,587.29 | 5,243 | BYSS4X4 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $49,888.00 | 12,472 | BMFJJ97 |
| 0.05% | SVRA | SAVARA INC | -- | $49,826.21 | 9,527 | BYXGN81 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $49,724.15 | 959 | BL95N25 |
| 0.05% | ORIC | ORIC PHARMACEUTICALS INC | -- | $48,837.60 | 4,560 | BKVDFF7 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $48,326.20 | 18,587 | BF0DMK7 |
| 0.05% | GERN | GERON CORP | -- | $48,121.29 | 29,889 | 2370381 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $48,004.80 | 2,192 | BZ7PJQ1 |
| 0.05% | VIR | VIR BIOTECHNOLOGY INC | -- | $47,421.92 | 6,514 | BK4PZ38 |
| 0.05% | VTYX | VENTYX BIOSCIENCES INC | -- | $46,606.95 | 3,341 | BMG99Y1 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $46,273.50 | 2,373 | BMNDK09 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $45,308.12 | 4,628 | BMCR7V2 |
| 0.05% | CTMX | CYTOMX THERAPEUTICS INC | -- | $45,218.10 | 7,933 | BYWVTY5 |
| 0.05% | ABCL | ABCELLERA BIOLOGICS INC | -- | $45,128.30 | 14,015 | BL53SR3 |
| 0.05% | GHRS | GH RESEARCH PLC | -- | $44,634.48 | 2,904 | BP6C0S2 |
| 0.05% | CSTL | CASTLE BIOSCIENCES INC | -- | $44,058.41 | 1,367 | BKLCWZ3 |
| 0.05% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $42,570.18 | 3,331 | BJLKVS6 |
| 0.05% | PCRX | PACIRA BIOSCIENCES INC | -- | $42,434.98 | 2,014 | B3X26D8 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $41,346.87 | 1,933 | BMGTLY5 |
| 0.04% | ARVN | ARVINAS INC | -- | $39,963.03 | 3,007 | BDZ30Q0 |
| 0.04% | XNCR | XENCOR INC | -- | $39,893.92 | 3,344 | BGCYWN8 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $38,526.88 | 2,296 | BQS7491 |
| 0.04% | BCAX | BICARA THERAPEUTICS INC | -- | $38,449.35 | 2,565 | BQB42F1 |
| 0.04% | ANNX | ANNEXON INC | -- | $38,154.51 | 6,777 | BMVV9R5 |
| 0.04% | OMER | OMEROS CORP | -- | $37,516.00 | 3,320 | B4NB858 |
| 0.04% | JANX | JANUX THERAPEUTICS INC | -- | $37,368.32 | 2,816 | BMFX8Y7 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $37,160.76 | 11,193 | BBNBTD2 |
| 0.04% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $36,866.28 | 7,617 | B3MZ6K5 |
| 0.04% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $36,470.25 | 9,005 | BZ0QMB7 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $34,960.59 | 2,367 | BD06CS0 |
| 0.04% | BIOA | BIOAGE LABS INC | -- | $34,436.29 | 1,679 | BT9K6D8 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $33,800.52 | 1,833 | BD9GVY0 |
| 0.04% | CGEM | CULLINAN THERAPEUTICS INC | -- | $32,721.78 | 2,766 | BM90J52 |
| 0.04% | PSNL | PERSONALIS INC | -- | $32,557.14 | 4,158 | BJQ0608 |
| 0.03% | KURA | KURA ONCOLOGY INC | -- | $31,654.98 | 4,074 | BYZD465 |
| 0.03% | PRME | PRIME MEDICINE INC | -- | $30,342.68 | 8,452 | BPBJFM7 |
| 0.03% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $29,248.50 | 850 | BQD3J33 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $28,757.47 | 3,769 | BFYQFJ2 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $28,678.00 | 4,412 | BMC3HS7 |
| 0.03% | REPL | REPLIMUNE GROUP INC | -- | $28,557.58 | 3,673 | BDDVW37 |
| 0.03% | CRMD | CORMEDIX INC | -- | $27,962.62 | 3,689 | BJ0LT31 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $27,683.46 | 2,667 | BMFK3H6 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $26,010.24 | 14,136 | B4N8MH9 |
| 0.03% | FULC | FULCRUM THERAPEUTICS INC | -- | $25,922.82 | 2,534 | BJDX8Z9 |
| 0.03% | SLDB | SOLID BIOSCIENCES INC | -- | $25,025.28 | 3,648 | BQHN6C7 |
| 0.03% | KROS | KEROS THERAPEUTICS INC | -- | $24,997.78 | 1,426 | BM7V485 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $24,602.40 | 3,417 | BQ6C357 |
| 0.03% | GOSS | GOSSAMER BIO INC | -- | $24,491.62 | 10,837 | BJ0CK86 |
| 0.03% | RGNX | REGENXBIO INC | -- | $24,434.70 | 2,370 | BZ0G875 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $24,289.00 | 2,675 | BKLXFX5 |
| 0.03% | LYEL | LYELL IMMUNOPHARMA INC | -- | $23,087.25 | 993 | BTNMG41 |
| 0.03% | ALT | ALTIMMUNE INC | -- | $22,915.34 | 4,886 | BFY7DC4 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $22,747.20 | 677 | B292NQ7 |
| 0.02% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $22,590.52 | 2,636 | BLFBZ32 |
| 0.02% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $22,505.28 | 5,712 | BYVQJ96 |
| 0.02% | KMDA | KAMADA LTD | -- | $22,364.28 | 2,701 | B2Q9833 |
| 0.02% | PRTA | PROTHENA CORP PLC | -- | $22,327.20 | 2,520 | B91XRN2 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $21,895.09 | 3,353 | 2107437 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $21,751.08 | 876 | BPBPCG8 |
| 0.02% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $21,116.90 | 6,790 | BMCWKZ2 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $20,780.17 | 2,767 | B12W3P6 |
| 0.02% | LENZ | LENZ THERAPEUTICS INC | -- | $20,524.65 | 1,465 | BQV0J03 |
| 0.02% | ABSI | ABSCI CORP | -- | $19,433.16 | 7,041 | BN94K69 |
| 0.02% | IVVD | INVIVYD INC | -- | $19,203.00 | 12,975 | BM8NHS1 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $18,884.50 | 1,790 | BP81RK8 |
| 0.02% | ACRS | ACLARIS THERAPEUTICS INC | -- | $18,719.37 | 5,073 | BYV2W40 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $18,696.97 | 7,823 | BN4JN37 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $18,684.33 | 1,351 | B9L5200 |
| 0.02% | ETON | ETON PHARMACEUTICALS INC | -- | $18,601.36 | 1,256 | BGL0JK3 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $18,196.05 | 4,183 | BYTYP72 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $17,782.18 | 10,522 | BFZNYB7 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $17,094.75 | 2,973 | BP81R42 |
| 0.02% | NBP | NOVABRIDGE BIOSCIENCES | -- | $16,891.96 | 4,868 | BKRRKY7 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $16,572.08 | 2,051 | BSMLR16 |
| 0.02% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $16,522.14 | 1,082 | BPRBTY7 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $16,229.92 | 2,359 | B7F2TY6 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $16,192.00 | 5,060 | BDFKQ07 |
| 0.02% | AVIR | ATEA PHARMACEUTICALS INC | -- | $15,144.12 | 3,658 | BLN9Z50 |
| 0.02% | PEPG | PEPGEN INC | -- | $15,032.73 | 3,219 | BMTX3D7 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $14,963.85 | 3,023 | BMVBZF5 |
| 0.02% | CADL | CANDEL THERAPEUTICS INC | -- | $14,828.90 | 2,570 | BP0TQC5 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $14,620.11 | 4,701 | BZC0D70 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $14,431.60 | 2,648 | BMF7DT9 |
| 0.02% | AARD | AARDVARK THERAPEUTICS INC | -- | $13,736.12 | 1,019 | BTXQTX3 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $13,712.32 | 9,392 | BFMLGR4 |
| 0.01% | LRMR | LARIMAR THERAPEUTICS INC | -- | $13,587.12 | 4,008 | BMXNGZ6 |
| 0.01% | LFCR | LIFECORE BIOMEDICAL INC | -- | $13,084.84 | 1,754 | 2517058 |
| 0.01% | EOLS | EVOLUS INC | -- | $12,868.40 | 3,035 | BDRJH21 |
| 0.01% | NGNE | NEUROGENE INC | -- | $12,774.50 | 725 | BS2F741 |
| 0.01% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $12,519.48 | 2,166 | BKDQKM6 |
| 0.01% | OABI | OMNIAB INC | -- | $12,064.60 | 6,740 | BN13S71 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $11,657.54 | 5,659 | BRK0149 |
| 0.01% | CABA | CABALETTA BIO INC | -- | $10,997.08 | 4,507 | BK5MWR1 |
| 0.01% | HUMA | HUMACYTE INC | -- | $10,696.96 | 8,768 | BMYTJP4 |
| 0.01% | VOR | VOR BIOPHARMA INC | -- | $10,391.13 | 789 | BRJJYT3 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $10,364.48 | 2,644 | BPRB2N7 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $10,235.89 | 2,759 | BY7RB53 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $10,014.90 | 1,330 | BKC9SX3 |
| 0.01% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $9,917.49 | 2,199 | BL5B6Z1 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $9,796.92 | 9,156 | BNR5QT9 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $8,273.51 | 4,571 | BZ8FPH3 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $8,077.64 | 4,538 | BKX9NQ0 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $7,913.40 | 1,452 | BP2NYN2 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $7,132.88 | 4,376 | BNYJR68 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $6,556.44 | 7,796 | BNNXX52 |
| 0.01% | MENS | JYONG BIOTECH LTD | -- | $6,016.40 | 3,560 | BPTK6Z2 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $5,976.32 | 2,668 | BKTV702 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $5,800.09 | 4,567 | BNNXX18 |
| 0.01% | CDXS | CODEXIS INC | -- | $5,455.41 | 4,229 | B5LL2C2 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $5,412.96 | 2,506 | BP7L561 |
| -- | PYXS | PYXIS ONCOLOGY INC | -- | $3,993.55 | 2,915 | BLBR8D5 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $13.98 | 01 | BTFHQP5 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| 40.91% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 37,074,321 | -- | 6,210 | -- |
| 29.09% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 26,357,992 | -- | 4,415 | -- |
| 22.80% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 20,662,516 | -- | 3,461 | -- |
| 17.39% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 15,755,094 | -- | 2,639 | -- |
| 16.36% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,829,728 | -- | 2,484 | -- |
| 4.17% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,779,073 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $28,107,334.06 | 28,107,334 | -- |
Index
as of 12/31/2025
- Total Number of Companies262
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$7.32 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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