BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
View fund details
Documents & Downloads
ETF & Index
Prospectus & Regulatory
You may order paper copies by contacting ProShares Client Services at 866-PRO-5125 (866-776-5125)
Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 11/30/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 16.90% | 51.72% | 95.62% | 66.67% | 42.59% | 11.36% | 1.61% | 2.01% | 16.86% | 04/07/2010 |
| BIB Market Price | 17.00% | 51.90% | 95.85% | 66.74% | 42.98% | 11.47% | 1.66% | 2.03% | 16.87% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/12/2025- NAV $80.22
- NAV Change $-0.48
- Market Price $80.24
- Market Price Change $-0.43
- Trading Volume (M) 15,748
- 30-Day Median Bid Ask Spread 0.26%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/12/2025- NAV $80.22
- NAV Change $-0.48
- Market Price $80.24
- Market Price Change $-0.43
- Trading Volume (M) 15,748
- 30-Day Median Bid Ask Spread 0.26%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 12/12/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.42% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $4,567,864.20 | 10,105 | 2931034 |
| 5.18% | AMGN | AMGEN INC | -- | $4,363,523.42 | 13,733 | 2023607 |
| 4.97% | GILD | GILEAD SCIENCES INC | -- | $4,183,359.75 | 34,975 | 2369174 |
| 4.34% | REGN | REGENERON PHARMACEUTICALS | -- | $3,656,783.57 | 4,933 | 2730190 |
| 2.93% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,467,592.85 | 6,207 | B00FWN1 |
| 2.64% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $2,221,136.58 | 24,726 | 2989044 |
| 2.36% | INSM | INSMED INC | -- | $1,988,027.91 | 10,091 | 2614487 |
| 1.52% | ARGX | ARGENX SE - ADR | -- | $1,283,548.28 | 1,462 | BDVLM39 |
| 1.45% | BIIB | BIOGEN INC | -- | $1,218,700.00 | 7,000 | 2455965 |
| 1.27% | UTHR | UNITED THERAPEUTICS CORP | -- | $1,066,524.41 | 2,159 | 2430412 |
| 1.18% | ILMN | ILLUMINA INC | -- | $989,810.93 | 7,339 | 2613990 |
| 1.06% | INCY | INCYTE CORP | -- | $889,602.84 | 9,324 | 2471950 |
| 0.94% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $792,407.99 | 20,641 | BMVP7Y0 |
| 0.89% | MEDP | MEDPACE HOLDINGS INC | -- | $748,143.90 | 1,341 | BDCBC61 |
| 0.86% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $723,660.80 | 4,736 | 2623911 |
| 0.86% | ROIV | ROIVANT SCIENCES LTD | -- | $720,570.50 | 32,605 | BMW4NZ9 |
| 0.84% | RVMD | REVOLUTION MEDICINES INC | -- | $704,361.00 | 8,925 | BL71K91 |
| 0.81% | BBIO | BRIDGEBIO PHARMA INC | -- | $685,969.20 | 9,128 | BK1KWG8 |
| 0.77% | VTRS | VIATRIS INC | -- | $648,508.90 | 55,666 | BMWS3X9 |
| 0.76% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $640,320.10 | 2,905 | BV9G6B8 |
| 0.74% | SNY | SANOFI-ADR | -- | $623,639.48 | 12,811 | 2964557 |
| 0.74% | SMMT | SUMMIT THERAPEUTICS INC | -- | $623,172.76 | 35,468 | BMTVQS7 |
| 0.73% | IONS | IONIS PHARMACEUTICALS INC | -- | $615,040.20 | 7,610 | BDJ0LS6 |
| 0.72% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $608,012.16 | 1,064 | BD59BS7 |
| 0.72% | GH | GUARDANT HEALTH INC | -- | $607,724.78 | 5,954 | BFXC911 |
| 0.68% | TEM | TEMPUS AI INC | -- | $568,763.55 | 8,055 | BSLSJJ0 |
| 0.65% | MRNA | MODERNA INC | -- | $547,278.42 | 18,577 | BGSXTS3 |
| 0.62% | EXEL | EXELIXIS INC | -- | $525,430.64 | 12,853 | 2576941 |
| 0.61% | ONC | BEONE MEDICINES LTD-ADR | -- | $512,091.30 | 1,605 | BYYWPW6 |
| 0.58% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $489,012.63 | 9,173 | 2437071 |
| 0.58% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $485,080.00 | 2,896 | B4Q5ZN4 |
| 0.55% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $462,664.09 | 6,601 | BYQBFJ8 |
| 0.54% | BNTX | BIONTECH SE-ADR | -- | $455,372.43 | 4,803 | BK6H543 |
| 0.52% | RNA | AVIDITY BIOSCIENCES INC | -- | $441,251.69 | 6,143 | BMWHPY1 |
| 0.43% | CYTK | CYTOKINETICS INC | -- | $361,918.55 | 5,713 | BBBSBJ5 |
| 0.43% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $360,325.88 | 3,173 | BF2YWG4 |
| 0.42% | AXSM | AXSOME THERAPEUTICS INC | -- | $353,089.11 | 2,383 | BYZR4X4 |
| 0.41% | HALO | HALOZYME THERAPEUTICS INC | -- | $347,442.85 | 5,585 | 2975098 |
| 0.40% | KRYS | KRYSTAL BIOTECH INC | -- | $338,106.30 | 1,382 | BD6JX35 |
| 0.40% | NUVL | NUVALENT INC-A | -- | $333,578.40 | 3,183 | BMVBZD3 |
| 0.36% | KYMR | KYMERA THERAPEUTICS INC | -- | $306,167.52 | 3,414 | BMPRZV5 |
| 0.34% | PTCT | PTC THERAPEUTICS INC | -- | $286,902.52 | 3,793 | B17VCN9 |
| 0.34% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $283,189.50 | 2,970 | BDCBCD8 |
| 0.33% | COGT | COGENT BIOSCIENCES INC | -- | $280,873.70 | 6,670 | BLR6XK8 |
| 0.33% | PCVX | VAXCYTE INC | -- | $275,855.50 | 6,199 | BKPVGH6 |
| 0.32% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $270,144.00 | 1,005 | BQ721R4 |
| 0.29% | CRSP | CRISPR THERAPEUTICS AG | -- | $246,161.24 | 4,343 | BDHF4K6 |
| 0.27% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $227,053.53 | 4,497 | BDD19F8 |
| 0.27% | ADMA | ADMA BIOLOGICS INC | -- | $225,373.32 | 11,394 | B9NSBM2 |
| 0.27% | ALKS | ALKERMES PLC | -- | $224,637.00 | 7,882 | B3P6D26 |
| 0.26% | IMVT | IMMUNOVANT INC | -- | $219,893.66 | 8,323 | BJRFSB7 |
| 0.26% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $218,693.25 | 8,055 | 2713317 |
| 0.26% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $215,133.30 | 4,590 | BFZQ0L8 |
| 0.25% | INDV | INDIVIOR PLC | -- | $211,830.92 | 5,957 | BP0BQQ5 |
| 0.24% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $200,330.50 | 5,378 | BP8JSP4 |
| 0.23% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $190,316.28 | 2,838 | BQS9486 |
| 0.23% | ACLX | ARCELLX INC | -- | $190,285.28 | 2,648 | BPCJ1Q2 |
| 0.22% | TERN | TERNS PHARMACEUTICALS INC | -- | $188,010.00 | 4,178 | BMDJ0C9 |
| 0.22% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $183,101.16 | 14,996 | BFNF1D6 |
| 0.21% | LGND | LIGAND PHARMACEUTICALS | -- | $177,418.80 | 936 | 2501578 |
| 0.20% | APGE | APOGEE THERAPEUTICS INC | -- | $169,730.16 | 2,202 | BM9HHL5 |
| 0.20% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $166,694.23 | 4,601 | BJ62Z18 |
| 0.20% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $166,139.50 | 5,725 | BKX9VD3 |
| 0.19% | TARS | TARSUS PHARMACEUTICALS INC | -- | $164,001.60 | 2,016 | BMH5RL1 |
| 0.19% | XENE | XENON PHARMACEUTICALS INC | -- | $162,228.92 | 3,682 | BRJ3GY4 |
| 0.19% | VCYT | VERACYTE INC | -- | $160,907.04 | 3,756 | BFTWZY0 |
| 0.19% | GRAL | GRAIL INC | -- | $156,301.22 | 1,721 | BSLSSX7 |
| 0.19% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $155,935.00 | 2,399 | BJDX8Y8 |
| 0.18% | FOLD | AMICUS THERAPEUTICS INC | -- | $155,264.35 | 14,717 | B19FQ48 |
| 0.18% | IRON | DISC MEDICINE INC | -- | $152,471.00 | 1,660 | BMGJZJ8 |
| 0.18% | APLS | APELLIS PHARMACEUTICALS INC | -- | $152,136.90 | 6,030 | BYTQ6X1 |
| 0.18% | VERA | VERA THERAPEUTICS INC | -- | $151,740.60 | 3,047 | BL55460 |
| 0.18% | CGON | CG ONCOLOGY INC | -- | $149,062.54 | 3,641 | BRBCSP4 |
| 0.18% | TVTX | TRAVERE THERAPEUTICS INC | -- | $148,236.48 | 4,256 | BLFGJD5 |
| 0.17% | IDYA | IDEAYA BIOSCIENCES INC | -- | $142,373.70 | 4,185 | BK0VHF6 |
| 0.16% | BEAM | BEAM THERAPEUTICS INC | -- | $132,148.80 | 4,830 | BK6L288 |
| 0.16% | DYN | DYNE THERAPEUTICS INC | -- | $130,901.11 | 6,793 | BN15WD1 |
| 0.15% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $126,247.32 | 2,677 | B72ZBG4 |
| 0.15% | WVE | WAVE LIFE SCIENCES LTD | -- | $125,822.88 | 7,598 | BYZG9R0 |
| 0.15% | DNLI | DENALI THERAPEUTICS INC | -- | $125,518.38 | 6,981 | BD2B4V0 |
| 0.14% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $121,442.31 | 4,581 | BLB0YQ9 |
| 0.14% | OCUL | OCULAR THERAPEUTIX INC | -- | $120,964.48 | 8,308 | BNZB1X8 |
| 0.14% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $118,808.60 | 5,030 | BKY5JZ8 |
| 0.14% | MLYS | MINERALYS THERAPEUTICS INC | -- | $116,788.50 | 3,165 | BP9N0G0 |
| 0.13% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $112,264.24 | 7,271 | BJ5FZ74 |
| 0.13% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $111,280.97 | 2,747 | BKSGZN7 |
| 0.13% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $108,304.85 | 3,277 | BMZ4LN0 |
| 0.13% | IBRX | IMMUNITYBIO INC | -- | $106,513.88 | 45,133 | BNSP0B8 |
| 0.12% | SRPT | SAREPTA THERAPEUTICS INC | -- | $100,437.45 | 4,665 | B8DPDT7 |
| 0.12% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $99,490.45 | 6,277 | BFWLC09 |
| 0.12% | AVDL | AVADEL PHARMACEUTICALS | -- | $99,024.96 | 4,636 | BDGMC59 |
| 0.12% | SYRE | SPYRE THERAPEUTICS INC | -- | $96,960.08 | 2,884 | BQBBDY8 |
| 0.11% | ZYME | ZYMEWORKS INC | -- | $91,447.72 | 3,589 | BPCQZY9 |
| 0.11% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $89,726.40 | 4,020 | BMX9K07 |
| 0.11% | TWST | TWIST BIOSCIENCE CORP | -- | $89,171.19 | 2,883 | BGKG6G7 |
| 0.10% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $88,344.99 | 20,403 | BM9FJ13 |
| 0.10% | VCEL | VERICEL CORP | -- | $88,024.86 | 2,409 | BSBMN89 |
| 0.10% | MNKD | MANNKIND CORP | -- | $87,021.00 | 14,650 | BF081J4 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $86,340.84 | 2,076 | BRXB0C0 |
| 0.10% | STOK | STOKE THERAPEUTICS INC | -- | $84,732.24 | 2,616 | BJQ05Z6 |
| 0.10% | TXG | 10X GENOMICS INC-CLASS A | -- | $84,457.98 | 5,463 | BKS3RS7 |
| 0.10% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $83,781.81 | 4,113 | BN7Q7R7 |
| 0.10% | ANIP | ANI PHARMACEUTICALS INC | -- | $83,284.04 | 1,036 | BCDWBX6 |
| 0.10% | ALVO | ALVOTECH SA | -- | $83,249.22 | 14,946 | BPNTJ34 |
| 0.10% | HROW | HARROW INC | -- | $83,155.02 | 1,767 | BHNDW86 |
| 0.09% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $75,874.11 | 10,023 | 2100362 |
| 0.09% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $75,646.98 | 2,774 | BCBVTX1 |
| 0.09% | TSHA | TAYSHA GENE THERAPIES INC | -- | $75,414.75 | 13,025 | BNC1BX1 |
| 0.09% | TRVI | TREVI THERAPEUTICS INC | -- | $74,244.78 | 5,814 | BJH9ZN0 |
| 0.09% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $73,139.52 | 1,504 | BX7RSN3 |
| 0.08% | ARDX | ARDELYX INC | -- | $71,452.26 | 11,506 | BN89V40 |
| 0.08% | NVCR | NOVOCURE LTD | -- | $71,102.16 | 5,338 | BYSS4X4 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $70,361.60 | 1,912 | BLCD809 |
| 0.08% | NRIX | NURIX THERAPEUTICS INC | -- | $69,605.50 | 3,650 | BMVLGP2 |
| 0.08% | FTRE | FORTREA HOLDINGS INC | -- | $68,146.20 | 4,335 | BRXYZ57 |
| 0.08% | RLAY | RELAY THERAPEUTICS INC | -- | $66,102.96 | 8,232 | BN2R582 |
| 0.08% | SANA | SANA BIOTECHNOLOGY INC | -- | $63,489.28 | 12,352 | BMFJJ97 |
| 0.07% | GMAB | GENMAB A/S -SP ADR | -- | $62,682.62 | 2,002 | BBC9WC7 |
| 0.07% | INVA | INNOVIVA INC | -- | $62,075.67 | 3,009 | BDDXF67 |
| 0.07% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $60,469.20 | 5,599 | BRJZSK0 |
| 0.07% | ANAB | ANAPTYSBIO INC | -- | $60,084.78 | 1,337 | BDRW1L7 |
| 0.07% | TYRA | TYRA BIOSCIENCES INC | -- | $57,593.35 | 2,545 | BMVNDH9 |
| 0.07% | SVRA | SAVARA INC | -- | $57,103.84 | 8,252 | BYXGN81 |
| 0.07% | PCRX | PACIRA BIOSCIENCES INC | -- | $56,392.05 | 2,145 | B3X26D8 |
| 0.07% | XNCR | XENCOR INC | -- | $56,250.60 | 3,405 | BGCYWN8 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $56,099.40 | 2,220 | BNFWZS4 |
| 0.07% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $55,766.70 | 4,257 | BPCK358 |
| 0.07% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $55,280.70 | 7,710 | BLR7H87 |
| 0.07% | INBX | INHIBRX BIOSCIENCES INC | -- | $55,062.44 | 692 | BNSP8K3 |
| 0.06% | ORKA | ORUKA THERAPEUTICS INC | -- | $53,961.84 | 1,788 | BKVF0J2 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $53,502.55 | 1,385 | BKLCWZ3 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $53,240.50 | 5,825 | B8K7T65 |
| 0.06% | ALMS | ALUMIS INC | -- | $53,152.74 | 4,626 | BPLQG36 |
| 0.06% | RAPP | RAPPORT THERAPEUTICS INC | -- | $52,760.61 | 1,743 | BR3T9B6 |
| 0.06% | EYPT | EYEPOINT PHARMACEUTICALS INC | -- | $52,623.09 | 3,291 | BMGS7L1 |
| 0.06% | PGEN | PRECIGEN INC | -- | $52,497.63 | 14,227 | BKM5C84 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $51,650.16 | 14,268 | BL53SR3 |
| 0.06% | QURE | UNIQURE NV | -- | $51,116.20 | 2,620 | BJFSR88 |
| 0.06% | NVAX | NOVAVAX INC | -- | $50,950.35 | 7,755 | BJDQXG4 |
| 0.06% | TNGX | TANGO THERAPEUTICS INC | -- | $49,667.20 | 5,312 | BP2P6L0 |
| 0.06% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $49,314.72 | 3,387 | BJLKVS6 |
| 0.06% | ERAS | ERASCA INC | -- | $48,758.40 | 13,544 | BNLYBF3 |
| 0.06% | SPRY | ARS PHARMACEUTICALS INC | -- | $48,322.56 | 4,719 | BMCR7V2 |
| 0.06% | URGN | UROGEN PHARMA LTD | -- | $48,156.20 | 2,209 | BZ7PJQ1 |
| 0.06% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $48,098.19 | 2,949 | BP7KZP7 |
| 0.06% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $47,680.08 | 2,828 | BMFD115 |
| 0.06% | AVBP | ARRIVENT BIOPHARMA INC | -- | $47,301.54 | 1,937 | BMGTLY5 |
| 0.05% | NTLA | INTELLIA THERAPEUTICS INC | -- | $46,227.50 | 5,125 | BYZM6C2 |
| 0.05% | MNMD | MIND MEDICINE MINDMED INC | -- | $45,594.15 | 3,633 | BPQYY97 |
| 0.05% | VIR | VIR BIOTECHNOLOGY INC | -- | $44,374.77 | 6,633 | BK4PZ38 |
| 0.05% | ARVN | ARVINAS INC | -- | $44,130.64 | 3,508 | BDZ30Q0 |
| 0.05% | JANX | JANUX THERAPEUTICS INC | -- | $43,895.70 | 2,869 | BMFX8Y7 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $43,698.85 | 2,405 | BMNDK09 |
| 0.05% | ORIC | ORIC PHARMACEUTICALS INC | -- | $43,495.06 | 4,637 | BKVDFF7 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $43,110.63 | 9,153 | BZ0QMB7 |
| 0.05% | KURA | KURA ONCOLOGY INC | -- | $42,351.68 | 4,144 | BYZD465 |
| 0.05% | KROS | KEROS THERAPEUTICS INC | -- | $41,707.89 | 1,939 | BM7V485 |
| 0.05% | GERN | GERON CORP | -- | $41,429.68 | 30,463 | 2370381 |
| 0.05% | CRMD | CORMEDIX INC | -- | $40,950.36 | 3,564 | BJ0LT31 |
| 0.05% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $40,888.76 | 4,891 | BLB0YH0 |
| 0.05% | MESO | MESOBLAST LTD- SPON ADR | -- | $40,729.78 | 2,254 | BQS7491 |
| 0.05% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $40,685.46 | 2,406 | BD06CS0 |
| 0.05% | ZLAB | ZAI LAB LTD-ADR | -- | $40,568.91 | 2,283 | BD9GVY0 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $39,025.80 | 972 | BL95N25 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $38,009.40 | 17,277 | BF0DMK7 |
| 0.05% | REPL | REPLIMUNE GROUP INC | -- | $37,940.86 | 3,727 | BDDVW37 |
| 0.04% | PSNL | PERSONALIS INC | -- | $37,132.18 | 4,234 | BJQ0608 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $37,063.95 | 9,627 | BBNBTD2 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $35,868.96 | 5,776 | BYVQJ96 |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $34,907.68 | 856 | BQD3J33 |
| 0.04% | ATXS | ASTRIA THERAPEUTICS INC | -- | $34,846.35 | 2,695 | BMYRFN8 |
| 0.04% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $34,261.72 | 3,841 | BFYQFJ2 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $34,230.90 | 8,349 | BPBJFM7 |
| 0.04% | CGEM | CULLINAN THERAPEUTICS INC | -- | $33,626.32 | 2,821 | BM90J52 |
| 0.04% | RGNX | REGENXBIO INC | -- | $33,454.44 | 2,412 | BZ0G875 |
| 0.04% | OMER | OMEROS CORP | -- | $32,977.35 | 3,249 | B4NB858 |
| 0.04% | LYEL | LYELL IMMUNOPHARMA INC | -- | $31,599.82 | 917 | BTNMG41 |
| 0.04% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $30,405.04 | 14,342 | B4N8MH9 |
| 0.04% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $29,797.20 | 3,560 | BYP80F1 |
| 0.04% | CMPS | COMPASS PATHWAYS PLC | -- | $29,514.46 | 4,379 | BMC3HS7 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $27,766.48 | 7,756 | B3MZ6K5 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $26,625.20 | 2,570 | B91XRN2 |
| 0.03% | ANNX | ANNEXON INC | -- | $26,077.59 | 5,247 | BMVV9R5 |
| 0.03% | ABSI | ABSCI CORP | -- | $25,985.96 | 7,139 | BN94K69 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $25,640.17 | 2,719 | BMFK3H6 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $25,187.06 | 2,578 | BQ6C357 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $24,868.80 | 6,908 | BMCWKZ2 |
| 0.03% | LENZ | LENZ THERAPEUTICS INC | -- | $24,706.68 | 1,362 | BQV0J03 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $24,173.20 | 2,230 | BKLXFX5 |
| 0.03% | LXRX | LEXICON PHARMACEUTICALS INC | -- | $22,556.30 | 17,351 | BWFZX59 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $22,324.40 | 2,680 | BLFBZ32 |
| 0.03% | ALT | ALTIMMUNE INC | -- | $22,207.78 | 4,214 | BFY7DC4 |
| 0.03% | SIGA | SIGA TECHNOLOGIES INC | -- | $22,086.74 | 3,419 | 2107437 |
| 0.03% | SLDB | SOLID BIOSCIENCES INC | -- | $21,824.66 | 3,718 | BQHN6C7 |
| 0.03% | EOLS | EVOLUS INC | -- | $21,746.56 | 3,089 | BDRJH21 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $21,675.96 | 684 | B292NQ7 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $20,121.28 | 1,816 | BP81RK8 |
| 0.02% | HCM | HUTCHMED CHINA-ADR | -- | $19,875.02 | 1,481 | BYXV9H7 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $19,397.64 | 2,966 | BP81R42 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $18,130.70 | 2,065 | BSMLR16 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $17,645.68 | 893 | BPBPCG8 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $17,574.83 | 2,821 | B12W3P6 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $17,465.28 | 5,152 | BDFKQ07 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $16,552.35 | 4,087 | BMXNGZ6 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $16,486.02 | 4,101 | BYTYP72 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $16,442.15 | 2,207 | BKDQKM6 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $16,159.88 | 7,732 | BN4JN37 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $15,996.94 | 10,594 | BFZNYB7 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $15,418.97 | 9,577 | BFMLGR4 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $15,101.10 | 4,794 | BZC0D70 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $15,039.33 | 1,021 | B9L5200 |
| 0.02% | NGNE | NEUROGENE INC | -- | $14,246.52 | 681 | BS2F741 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $14,169.44 | 2,242 | BL5B6Z1 |
| 0.02% | AMRN | AMARIN CORP PLC -ADR | -- | $13,828.68 | 963 | BN72KB0 |
| 0.02% | PYXS | PYXIS ONCOLOGY INC | -- | $12,732.30 | 2,961 | BLBR8D5 |
| 0.01% | OABI | OMNIAB INC | -- | $12,596.85 | 5,859 | BN13S71 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $12,034.05 | 2,555 | BP7L561 |
| 0.01% | FHTX | FOGHORN THERAPEUTICS INC | -- | $11,983.56 | 2,699 | BMF7DT9 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $11,935.35 | 3,789 | BLN9Z50 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $11,624.72 | 2,648 | BY7RB53 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $10,861.29 | 4,293 | BZ8FPH3 |
| 0.01% | RNAC | CARTESIAN THERAPEUTICS INC | -- | $10,581.84 | 1,242 | BQB9HM8 |
| 0.01% | HUMA | HUMACYTE INC | -- | $9,906.22 | 7,562 | BMYTJP4 |
| 0.01% | CLYM | CLIMB BIO INC | -- | $9,708.00 | 3,236 | BMW5LX6 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $9,675.62 | 1,297 | BKC9SX3 |
| 0.01% | PEPG | PEPGEN INC | -- | $8,863.56 | 1,566 | BMTX3D7 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $8,393.06 | 3,398 | BKX9NQ0 |
| 0.01% | MXCT | MAXCYTE INC | -- | $7,736.80 | 5,090 | BKMQF66 |
| 0.01% | ALEC | ALECTOR INC | -- | $7,201.17 | 4,833 | BJ4LDC4 |
| 0.01% | CDXS | CODEXIS INC | -- | $7,197.70 | 4,310 | B5LL2C2 |
| 0.01% | MRSN | MERSANA THERAPEUTICS INC | -- | $6,747.30 | 238 | BVPKH99 |
| 0.01% | NKTX | NKARTA INC | -- | $6,375.08 | 3,391 | BK80YJ8 |
| 0.01% | FATE | FATE THERAPEUTICS INC | -- | $6,333.05 | 5,507 | BCZS820 |
| 0.01% | MGNX | MACROGENICS INC | -- | $4,225.20 | 3,018 | BFDV8K0 |
| -- | BMEA | BIOMEA FUSION INC | -- | $4,005.81 | 2,841 | BNKF6N0 |
| -- | -- | SUTRO BIOPHARMA INC COMMON STOCK USD 0.001 | -- | $3,981.15 | 405 | -- |
| -- | ARTV | ARTIVA BIOTHERAPEUTICS INC | -- | $3,847.80 | 1,166 | BMF1LJ7 |
| -- | ACRV | ACRIVON THERAPEUTICS INC | -- | $3,800.06 | 1,502 | BP2TPK4 |
| -- | TVGN | TEVOGEN BIO HOLDINGS INC | -- | $3,789.67 | 9,392 | BPG5P75 |
| -- | PLRX | PLIANT THERAPEUTICS INC | -- | $3,605.13 | 2,931 | BMDWW66 |
| -- | TCRX | TSCAN THERAPEUTICS INC | -- | $2,530.05 | 2,505 | BNLYBJ7 |
| -- | OKUR | ONKURE THERAPEUTICS INC-A | -- | $1,881.91 | 613 | BT7KGT6 |
| -- | QTTB | Q32 BIO INC | -- | $1,722.72 | 582 | BS2FKQ4 |
| -- | APLT | APPLIED THERAPEUTICS INC | -- | $806.55 | 6,876 | BJL38Z1 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 33.96% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 28,600,087 | -- | 5,008 | -- |
| 33.62% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 28,314,543 | -- | 4,958 | -- |
| 25.21% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 21,233,052 | -- | 3,718 | -- |
| 16.84% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,185,826 | -- | 2,484 | -- |
| 15.59% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 13,129,313 | -- | 2,299 | -- |
| 4.29% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,614,987 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $25,326,516.78 | 25,326,517 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
Read More