BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 12/31/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 1/22/2026- NAV $88.21
- NAV Change $+2.75
- Market Price $88.17
- Market Price Change $+2.74
- Trading Volume (M) 16,391
- 30-Day Median Bid Ask Spread 0.26%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 1/22/2026- NAV $88.21
- NAV Change $+2.75
- Market Price $88.17
- Market Price Change $+2.74
- Trading Volume (M) 16,391
- 30-Day Median Bid Ask Spread 0.26%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 12/31/2025
Holdings
as of 1/22/2026
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.83% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,400,229.25 | 11,555 | 2931034 |
| 5.64% | GILD | GILEAD SCIENCES INC | -- | $5,221,207.96 | 39,814 | 2369174 |
| 5.43% | AMGN | AMGEN INC | -- | $5,033,556.21 | 14,503 | 2023607 |
| 3.88% | REGN | REGENERON PHARMACEUTICALS | -- | $3,594,716.58 | 4,758 | 2730190 |
| 2.43% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,254,040.00 | 6,092 | B00FWN1 |
| 1.70% | INSM | INSMED INC | -- | $1,575,992.14 | 9,826 | 2614487 |
| 1.27% | BIIB | BIOGEN INC | -- | $1,174,714.20 | 6,759 | 2455965 |
| 1.20% | ARGX | ARGENX SE - ADR | -- | $1,109,033.82 | 1,341 | BDVLM39 |
| 1.17% | ILMN | ILLUMINA INC | -- | $1,083,808.00 | 7,040 | 2613990 |
| 1.14% | RVMD | REVOLUTION MEDICINES INC | -- | $1,058,240.67 | 8,907 | BL71K91 |
| 1.03% | INCY | INCYTE CORP | -- | $950,267.70 | 9,045 | 2471950 |
| 1.01% | UTHR | UNITED THERAPEUTICS CORP | -- | $936,567.04 | 1,984 | 2430412 |
| 1.01% | MRNA | MODERNA INC | -- | $933,608.13 | 17,999 | BGSXTS3 |
| 0.85% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $789,404.91 | 19,681 | BMVP7Y0 |
| 0.85% | MEDP | MEDPACE HOLDINGS INC | -- | $787,544.73 | 1,299 | BDCBC61 |
| 0.79% | ROIV | ROIVANT SCIENCES LTD | -- | $736,188.50 | 32,050 | BMW4NZ9 |
| 0.77% | BBIO | BRIDGEBIO PHARMA INC | -- | $709,440.98 | 8,878 | BK1KWG8 |
| 0.76% | VTRS | VIATRIS INC | -- | $702,567.36 | 53,064 | BMWS3X9 |
| 0.75% | GH | GUARDANT HEALTH INC | -- | $699,106.08 | 5,961 | BFXC911 |
| 0.70% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $646,850.85 | 2,829 | BV9G6B8 |
| 0.68% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $631,077.78 | 4,594 | 2623911 |
| 0.66% | IONS | IONIS PHARMACEUTICALS INC | -- | $610,316.98 | 7,462 | BDJ0LS6 |
| 0.64% | SMMT | SUMMIT THERAPEUTICS INC | -- | $595,756.26 | 34,298 | BMTVQS7 |
| 0.61% | SNY | SANOFI-ADR | -- | $566,928.00 | 12,192 | 2964557 |
| 0.60% | BNTX | BIONTECH SE-ADR | -- | $551,833.26 | 4,658 | BK6H543 |
| 0.59% | EXEL | EXELIXIS INC | -- | $549,797.50 | 12,355 | 2576941 |
| 0.59% | TEM | TEMPUS AI INC | -- | $544,487.40 | 7,965 | BSLSJJ0 |
| 0.56% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $521,945.92 | 1,048 | BD59BS7 |
| 0.55% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $506,157.36 | 8,852 | 2437071 |
| 0.55% | RNA | AVIDITY BIOSCIENCES INC | -- | $504,961.08 | 6,942 | BMWHPY1 |
| 0.53% | ONC | BEONE MEDICINES LTD-ADR | -- | $491,274.50 | 1,450 | BYYWPW6 |
| 0.52% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $478,800.00 | 2,800 | B4Q5ZN4 |
| 0.47% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $435,007.09 | 6,251 | BYQBFJ8 |
| 0.47% | AXSM | AXSOME THERAPEUTICS INC | -- | $434,167.56 | 2,322 | BYZR4X4 |
| 0.42% | KRYS | KRYSTAL BIOTECH INC | -- | $386,271.00 | 1,336 | BD6JX35 |
| 0.42% | HALO | HALOZYME THERAPEUTICS INC | -- | $386,249.22 | 5,418 | 2975098 |
| 0.40% | NUVL | NUVALENT INC-A | -- | $372,814.71 | 3,329 | BMVBZD3 |
| 0.39% | CYTK | CYTOKINETICS INC | -- | $365,750.69 | 5,633 | BBBSBJ5 |
| 0.38% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $350,645.76 | 1,152 | BQ721R4 |
| 0.36% | ABVX | ABIVAX SA-ADR | -- | $336,149.97 | 2,719 | BLC89B2 |
| 0.36% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $333,098.64 | 3,074 | BF2YWG4 |
| 0.36% | IBRX | IMMUNITYBIO INC | -- | $333,089.20 | 45,380 | BNSP0B8 |
| 0.36% | CAI | CARIS LIFE SCIENCES INC | -- | $332,124.45 | 12,999 | BT18HP9 |
| 0.35% | PCVX | VAXCYTE INC | -- | $324,648.73 | 6,031 | BKPVGH6 |
| 0.31% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $282,775.86 | 3,078 | BQS9486 |
| 0.30% | PTCT | PTC THERAPEUTICS INC | -- | $281,752.83 | 3,699 | B17VCN9 |
| 0.30% | COGT | COGENT BIOSCIENCES INC | -- | $279,674.75 | 7,075 | BLR6XK8 |
| 0.29% | CRSP | CRISPR THERAPEUTICS AG | -- | $267,259.95 | 4,395 | BDHF4K6 |
| 0.28% | ALKS | ALKERMES PLC | -- | $258,291.60 | 7,608 | B3P6D26 |
| 0.26% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $244,195.20 | 2,880 | BDCBCD8 |
| 0.26% | KYMR | KYMERA THERAPEUTICS INC | -- | $241,232.55 | 3,315 | BMPRZV5 |
| 0.26% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $240,351.30 | 4,374 | BDD19F8 |
| 0.25% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $227,399.04 | 2,368 | BJDX8Y8 |
| 0.24% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $224,567.52 | 4,702 | BFZQ0L8 |
| 0.23% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $214,440.45 | 7,795 | 2713317 |
| 0.23% | IMVT | IMMUNOVANT INC | -- | $211,482.04 | 8,078 | BJRFSB7 |
| 0.23% | GRAL | GRAIL INC | -- | $208,443.76 | 1,796 | BSLSSX7 |
| 0.22% | CGON | CG ONCOLOGY INC | -- | $207,538.60 | 3,716 | BRBCSP4 |
| 0.22% | FOLD | AMICUS THERAPEUTICS INC | -- | $202,848.05 | 14,215 | B19FQ48 |
| 0.22% | APGE | APOGEE THERAPEUTICS INC | -- | $201,806.22 | 2,527 | BM9HHL5 |
| 0.21% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $196,679.14 | 14,483 | BFNF1D6 |
| 0.21% | INDV | INDIVIOR PLC | -- | $192,989.16 | 5,754 | BP0BQQ5 |
| 0.21% | ADMA | ADMA BIOLOGICS INC | -- | $190,791.00 | 10,965 | B9NSBM2 |
| 0.20% | LGND | LIGAND PHARMACEUTICALS | -- | $184,864.74 | 907 | 2501578 |
| 0.20% | ACLX | ARCELLX INC | -- | $182,803.68 | 2,664 | BPCJ1Q2 |
| 0.20% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $181,847.44 | 5,224 | BP8JSP4 |
| 0.17% | BEAM | BEAM THERAPEUTICS INC | -- | $160,165.50 | 4,675 | BK6L288 |
| 0.17% | VCYT | VERACYTE INC | -- | $159,519.60 | 3,642 | BFTWZY0 |
| 0.16% | XENE | XENON PHARMACEUTICALS INC | -- | $150,458.88 | 3,562 | BRJ3GY4 |
| 0.16% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $150,385.95 | 5,643 | BKX9VD3 |
| 0.16% | TERN | TERNS PHARMACEUTICALS INC | -- | $149,311.47 | 4,151 | BMDJ0C9 |
| 0.16% | IDYA | IDEAYA BIOSCIENCES INC | -- | $146,211.80 | 4,039 | BK0VHF6 |
| 0.16% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $145,266.84 | 4,878 | BKY5JZ8 |
| 0.15% | VERA | VERA THERAPEUTICS INC | -- | $143,465.68 | 2,945 | BL55460 |
| 0.15% | DNLI | DENALI THERAPEUTICS INC | -- | $141,424.01 | 6,757 | BD2B4V0 |
| 0.15% | TARS | TARSUS PHARMACEUTICALS INC | -- | $138,863.65 | 1,955 | BMH5RL1 |
| 0.15% | IRON | DISC MEDICINE INC | -- | $136,068.00 | 1,740 | BMGJZJ8 |
| 0.15% | ERAS | ERASCA INC | -- | $134,500.59 | 13,071 | BNLYBF3 |
| 0.14% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $133,972.74 | 7,029 | BJ5FZ74 |
| 0.14% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $129,722.20 | 2,642 | B72ZBG4 |
| 0.14% | APLS | APELLIS PHARMACEUTICALS INC | -- | $128,260.00 | 5,830 | BYTQ6X1 |
| 0.14% | TWST | TWIST BIOSCIENCE CORP | -- | $127,232.70 | 2,818 | BGKG6G7 |
| 0.13% | MLYS | MINERALYS THERAPEUTICS INC | -- | $124,984.88 | 3,646 | BP9N0G0 |
| 0.13% | TXG | 10X GENOMICS INC-CLASS A | -- | $124,507.11 | 5,369 | BKS3RS7 |
| 0.13% | TVTX | TRAVERE THERAPEUTICS INC | -- | $122,547.06 | 4,122 | BLFGJD5 |
| 0.13% | SYRE | SPYRE THERAPEUTICS INC | -- | $121,837.66 | 3,574 | BQBBDY8 |
| 0.13% | DYN | DYNE THERAPEUTICS INC | -- | $118,966.40 | 6,580 | BN15WD1 |
| 0.13% | ALMS | ALUMIS INC | -- | $117,708.12 | 4,479 | BPLQG36 |
| 0.13% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $117,502.40 | 23,690 | BM9FJ13 |
| 0.12% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $109,569.25 | 4,445 | BLB0YQ9 |
| 0.12% | OCUL | OCULAR THERAPEUTIX INC | -- | $109,198.40 | 9,820 | BNZB1X8 |
| 0.11% | WVE | WAVE LIFE SCIENCES LTD | -- | $106,441.64 | 7,702 | BYZG9R0 |
| 0.11% | SRPT | SAREPTA THERAPEUTICS INC | -- | $105,180.33 | 4,827 | B8DPDT7 |
| 0.11% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $104,013.00 | 4,445 | BJ62Z18 |
| 0.11% | MAZE | MAZE THERAPEUTICS INC | -- | $102,425.40 | 2,217 | BSRK699 |
| 0.11% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $97,561.04 | 2,654 | BKSGZN7 |
| 0.10% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $95,693.24 | 3,622 | BMZ4LN0 |
| 0.10% | VCEL | VERICEL CORP | -- | $91,196.20 | 2,330 | BSBMN89 |
| 0.10% | NRIX | NURIX THERAPEUTICS INC | -- | $90,551.30 | 4,670 | BMVLGP2 |
| 0.10% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $90,437.96 | 6,086 | BFWLC09 |
| 0.10% | GMAB | GENMAB A/S -SP ADR | -- | $89,138.30 | 2,693 | BBC9WC7 |
| 0.10% | ARDX | ARDELYX INC | -- | $88,776.35 | 11,195 | BN89V40 |
| 0.10% | ANIP | ANI PHARMACEUTICALS INC | -- | $88,378.65 | 1,035 | BCDWBX6 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $88,317.64 | 2,081 | BRXB0C0 |
| 0.09% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $87,814.32 | 3,441 | BYP80F1 |
| 0.09% | MBX | MBX BIOSCIENCES INC | -- | $87,704.91 | 2,069 | BQXJKH2 |
| 0.09% | SION | SIONNA THERAPEUTICS INC | -- | $85,879.12 | 2,056 | BQKXDX4 |
| 0.09% | NTLA | INTELLIA THERAPEUTICS INC | -- | $84,906.00 | 5,340 | BYZM6C2 |
| 0.09% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $84,666.50 | 5,410 | BRJZSK0 |
| 0.09% | MNKD | MANNKIND CORP | -- | $83,697.42 | 14,162 | BF081J4 |
| 0.09% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $83,263.95 | 4,005 | BN7Q7R7 |
| 0.09% | PHVS | PHARVARIS NV | -- | $82,568.98 | 2,951 | BMZ2X38 |
| 0.09% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $82,107.57 | 5,059 | BPCK358 |
| 0.09% | ZYME | ZYMEWORKS INC | -- | $81,200.40 | 3,448 | BPCQZY9 |
| 0.09% | ORKA | ORUKA THERAPEUTICS INC | -- | $79,267.43 | 2,231 | BKVF0J2 |
| 0.09% | UPB | UPSTREAM BIO INC | -- | $79,157.10 | 2,490 | BRCFFK6 |
| 0.09% | PGEN | PRECIGEN INC | -- | $79,080.76 | 16,339 | BKM5C84 |
| 0.09% | STOK | STOKE THERAPEUTICS INC | -- | $79,061.55 | 2,631 | BJQ05Z6 |
| 0.08% | HROW | HARROW INC | -- | $77,361.24 | 1,707 | BHNDW86 |
| 0.08% | -- | DEFINIUM THERAPEUTICS INC COMMON STOCK USD 0 | -- | $77,009.86 | 4,538 | -- |
| 0.08% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $76,980.76 | 2,686 | BCBVTX1 |
| 0.08% | TNGX | TANGO THERAPEUTICS INC | -- | $76,631.75 | 6,205 | BP2P6L0 |
| 0.08% | TYRA | TYRA BIOSCIENCES INC | -- | $76,007.69 | 2,459 | BMVNDH9 |
| 0.08% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $75,019.86 | 3,879 | BMX9K07 |
| 0.08% | ALVO | ALVOTECH SA | -- | $74,561.74 | 14,422 | BPNTJ34 |
| 0.08% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $73,900.02 | 2,734 | BMFD115 |
| 0.08% | FTRE | FORTREA HOLDINGS INC | -- | $73,858.95 | 4,257 | BRXYZ57 |
| 0.08% | RAPT | RAPT THERAPEUTICS INC | -- | $73,606.28 | 1,277 | BTJZB49 |
| 0.08% | NVCR | NOVOCURE LTD | -- | $73,206.21 | 5,159 | BYSS4X4 |
| 0.08% | NVAX | NOVAVAX INC | -- | $72,998.25 | 7,487 | BJDQXG4 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $70,410.30 | 2,010 | BLCD809 |
| 0.07% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $69,060.00 | 3,000 | BP7KZP7 |
| 0.07% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $68,577.60 | 1,456 | BX7RSN3 |
| 0.07% | KOD | KODIAK SCIENCES INC | -- | $68,529.76 | 2,444 | BFXC933 |
| 0.07% | INVA | INNOVIVA INC | -- | $68,004.30 | 3,445 | BDDXF67 |
| 0.07% | ATAI | ATAIBECKLEY INC | -- | $66,430.01 | 16,733 | BWJDYK1 |
| 0.07% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $65,475.00 | 9,700 | 2100362 |
| 0.07% | QURE | UNIQURE NV | -- | $65,120.30 | 2,870 | BJFSR88 |
| 0.07% | TRVI | TREVI THERAPEUTICS INC | -- | $64,633.52 | 5,908 | BJH9ZN0 |
| 0.07% | TSHA | TAYSHA GENE THERAPIES INC | -- | $64,235.80 | 12,620 | BNC1BX1 |
| 0.07% | ABCL | ABCELLERA BIOLOGICS INC | -- | $63,990.24 | 13,791 | BL53SR3 |
| 0.07% | EYPT | EYEPOINT INC | -- | $62,383.37 | 3,819 | BMGS7L1 |
| 0.07% | SANA | SANA BIOTECHNOLOGY INC | -- | $61,360.00 | 12,272 | BMFJJ97 |
| 0.07% | RAPP | RAPPORT THERAPEUTICS INC | -- | $61,228.56 | 2,193 | BR3T9B6 |
| 0.07% | RLAY | RELAY THERAPEUTICS INC | -- | $60,724.00 | 7,990 | BN2R582 |
| 0.07% | SVRA | SAVARA INC | -- | $60,556.04 | 9,374 | BYXGN81 |
| 0.07% | ANAB | ANAPTYSBIO INC | -- | $60,393.08 | 1,276 | BDRW1L7 |
| 0.06% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $58,380.54 | 4,731 | BLB0YH0 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $58,170.84 | 7,644 | BLR7H87 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $56,691.75 | 1,345 | BKLCWZ3 |
| 0.06% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $55,348.97 | 2,117 | BNFWZS4 |
| 0.06% | SEPN | SEPTERNA INC | -- | $55,020.21 | 2,063 | BQNKXX2 |
| 0.06% | ORIC | ORIC PHARMACEUTICALS INC | -- | $54,068.35 | 4,487 | BKVDFF7 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $53,258.30 | 670 | BNSP8K3 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $51,207.31 | 5,621 | B8K7T65 |
| 0.05% | ZBIO | ZENAS BIOPHARMA INC | -- | $50,571.60 | 2,479 | BQB42H3 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $49,412.61 | 18,369 | BF0DMK7 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $48,407.16 | 2,334 | BMNDK09 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $48,135.78 | 4,554 | BMCR7V2 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $47,930.40 | 1,902 | BMGTLY5 |
| 0.05% | GHRS | GH RESEARCH PLC | -- | $47,842.92 | 2,858 | BP6C0S2 |
| 0.05% | VIR | VIR BIOTECHNOLOGY INC | -- | $47,434.00 | 6,410 | BK4PZ38 |
| 0.05% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $46,599.96 | 3,284 | BJLKVS6 |
| 0.05% | ANNX | ANNEXON INC | -- | $46,520.64 | 6,684 | BMVV9R5 |
| 0.05% | PSNL | PERSONALIS INC | -- | $46,023.75 | 4,091 | BJQ0608 |
| 0.05% | VTYX | VENTYX BIOSCIENCES INC | -- | $45,755.04 | 3,287 | BMG99Y1 |
| 0.05% | CTMX | CYTOMX THERAPEUTICS INC | -- | $44,736.12 | 7,821 | BYWVTY5 |
| 0.05% | BCAX | BICARA THERAPEUTICS INC | -- | $44,432.34 | 2,526 | BQB42F1 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $43,140.00 | 2,157 | BZ7PJQ1 |
| 0.05% | XNCR | XENCOR INC | -- | $43,131.90 | 3,290 | BGCYWN8 |
| 0.05% | MESO | MESOBLAST LTD- SPON ADR | -- | $42,401.43 | 2,259 | BQS7491 |
| 0.05% | JANX | JANUX THERAPEUTICS INC | -- | $41,952.94 | 2,771 | BMFX8Y7 |
| 0.04% | GERN | GERON CORP | -- | $41,468.10 | 29,410 | 2370381 |
| 0.04% | PCRX | PACIRA BIOSCIENCES INC | -- | $41,166.14 | 1,982 | B3X26D8 |
| 0.04% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $40,306.42 | 7,478 | B3MZ6K5 |
| 0.04% | OMER | OMEROS CORP | -- | $39,694.05 | 3,267 | B4NB858 |
| 0.04% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $39,196.62 | 942 | BL95N25 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $38,928.73 | 8,327 | BPBJFM7 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $38,538.20 | 2,330 | BD06CS0 |
| 0.04% | RGNX | REGENXBIO INC | -- | $37,265.36 | 2,332 | BZ0G875 |
| 0.04% | ARVN | ARVINAS INC | -- | $37,194.63 | 2,959 | BDZ30Q0 |
| 0.04% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $37,139.70 | 13,910 | B4N8MH9 |
| 0.04% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $36,949.12 | 8,882 | BZ0QMB7 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $36,441.81 | 4,009 | BYZD465 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $34,914.38 | 11,014 | BBNBTD2 |
| 0.04% | CGEM | CULLINAN THERAPEUTICS INC | -- | $34,215.54 | 2,722 | BM90J52 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $33,121.11 | 1,803 | BD9GVY0 |
| 0.03% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $31,747.41 | 837 | BQD3J33 |
| 0.03% | BIOA | BIOAGE LABS INC | -- | $31,222.80 | 1,652 | BT9K6D8 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $30,951.33 | 4,341 | BMC3HS7 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $30,821.79 | 3,709 | BFYQFJ2 |
| 0.03% | GOSS | GOSSAMER BIO INC | -- | $30,665.95 | 10,685 | BJ0CK86 |
| 0.03% | LENZ | LENZ THERAPEUTICS INC | -- | $30,650.07 | 1,441 | BQV0J03 |
| 0.03% | REPL | REPLIMUNE GROUP INC | -- | $28,550.60 | 3,614 | BDDVW37 |
| 0.03% | IVVD | INVIVYD INC | -- | $28,215.07 | 12,767 | BM8NHS1 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $27,866.88 | 2,624 | BMFK3H6 |
| 0.03% | FULC | FULCRUM THERAPEUTICS INC | -- | $27,547.65 | 2,493 | BJDX8Z9 |
| 0.03% | KROS | KEROS THERAPEUTICS INC | -- | $27,321.84 | 1,404 | BM7V485 |
| 0.03% | CRMD | CORMEDIX INC | -- | $27,007.20 | 3,630 | BJ0LT31 |
| 0.03% | ALT | ALTIMMUNE INC | -- | $25,867.04 | 4,808 | BFY7DC4 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $25,820.16 | 3,362 | BQ6C357 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $25,643.20 | 2,480 | B91XRN2 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $25,588.23 | 6,681 | BMCWKZ2 |
| 0.03% | LYEL | LYELL IMMUNOPHARMA INC | -- | $25,271.52 | 978 | BTNMG41 |
| 0.03% | SLDB | SOLID BIOSCIENCES INC | -- | $24,620.54 | 3,589 | BQHN6C7 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $23,553.52 | 2,594 | BLFBZ32 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $22,910.40 | 666 | B292NQ7 |
| 0.02% | ACRS | ACLARIS THERAPEUTICS INC | -- | $22,613.76 | 4,992 | BYV2W40 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $22,202.27 | 3,299 | 2107437 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $22,056.30 | 2,723 | B12W3P6 |
| 0.02% | ABSI | ABSCI CORP | -- | $21,892.48 | 6,928 | BN94K69 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $21,841.30 | 4,121 | BYTYP72 |
| 0.02% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $21,292.88 | 2,632 | BKLXFX5 |
| 0.02% | KMDA | KAMADA LTD | -- | $21,210.84 | 2,658 | B2Q9833 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $21,209.18 | 2,018 | BSMLR16 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $20,621.31 | 1,761 | BP81RK8 |
| 0.02% | ETON | ETON PHARMACEUTICALS INC | -- | $18,858.45 | 1,235 | BGL0JK3 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $18,847.08 | 4,986 | BDFKQ07 |
| 0.02% | NBP | NOVABRIDGE BIOSCIENCES | -- | $18,633.10 | 4,790 | BKRRKY7 |
| 0.02% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $18,268.25 | 5,621 | BYVQJ96 |
| 0.02% | PEPG | PEPGEN INC | -- | $17,830.21 | 3,167 | BMTX3D7 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $17,808.88 | 10,354 | BFZNYB7 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $17,024.00 | 1,330 | B9L5200 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $16,795.24 | 2,926 | BP81R42 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $16,792.38 | 4,626 | BZC0D70 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $16,421.10 | 862 | BPBPCG8 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $16,165.80 | 7,698 | BN4JN37 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $16,157.20 | 2,606 | BMF7DT9 |
| 0.02% | CADL | CANDEL THERAPEUTICS INC | -- | $15,939.00 | 2,530 | BP0TQC5 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $15,922.06 | 2,321 | B7F2TY6 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $15,907.86 | 2,979 | BMVBZF5 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $15,393.04 | 2,132 | BKDQKM6 |
| 0.02% | EOLS | EVOLUS INC | -- | $15,168.88 | 2,986 | BDRJH21 |
| 0.02% | AARD | AARDVARK THERAPEUTICS INC | -- | $15,125.24 | 1,003 | BTXQTX3 |
| 0.02% | LFCR | LIFECORE BIOMEDICAL INC | -- | $14,834.93 | 1,727 | 2517058 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $14,047.84 | 9,242 | BFMLGR4 |
| 0.01% | OABI | OMNIAB INC | -- | $13,730.31 | 6,633 | BN13S71 |
| 0.01% | LRMR | LARIMAR THERAPEUTICS INC | -- | $13,603.35 | 3,943 | BMXNGZ6 |
| 0.01% | NGNE | NEUROGENE INC | -- | $13,539.87 | 713 | BS2F741 |
| 0.01% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $13,450.95 | 1,065 | BPRBTY7 |
| 0.01% | VOR | VOR BIOPHARMA INC | -- | $13,401.52 | 776 | BRJJYT3 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $13,136.35 | 3,599 | BLN9Z50 |
| 0.01% | CABA | CABALETTA BIO INC | -- | $13,038.90 | 4,435 | BK5MWR1 |
| 0.01% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $12,594.48 | 2,164 | BL5B6Z1 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $11,801.79 | 9,009 | BNR5QT9 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $11,147.90 | 2,719 | BY7RB53 |
| 0.01% | MENS | JYONG BIOTECH LTD | -- | $11,066.32 | 3,502 | BPTK6Z2 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $10,746.26 | 2,602 | BPRB2N7 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $10,705.24 | 4,498 | BZ8FPH3 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $9,935.31 | 1,309 | BKC9SX3 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $9,733.70 | 4,465 | BKX9NQ0 |
| 0.01% | HUMA | HUMACYTE INC | -- | $9,663.36 | 8,628 | BMYTJP4 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $9,086.85 | 1,431 | BP2NYN2 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $8,854.71 | 5,569 | BRK0149 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $8,211.78 | 2,466 | BP7L561 |
| 0.01% | CDXS | CODEXIS INC | -- | $7,614.63 | 4,161 | B5LL2C2 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $6,975.72 | 4,306 | BNYJR68 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $6,956.25 | 2,625 | BKTV702 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $6,246.66 | 4,494 | BNNXX18 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $5,783.92 | 7,672 | BNNXX52 |
| 0.01% | PYXS | PYXIS ONCOLOGY INC | -- | $4,905.99 | 2,869 | BLBR8D5 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $16.32 | 01 | BTFHQP5 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| 42.98% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 39,808,864 | -- | 6,611 | -- |
| 28.79% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 26,669,711 | -- | 4,429 | -- |
| 23.26% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 21,539,299 | -- | 3,577 | -- |
| 17.16% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 15,891,029 | -- | 2,639 | -- |
| 16.15% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,957,679 | -- | 2,484 | -- |
| 4.12% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,811,679 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $30,487,188.80 | 30,487,189 | -- |
Index
as of 12/31/2025
- Total Number of Companies262
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$7.32 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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