BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 11/30/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 16.90% | 51.72% | 95.62% | 66.67% | 42.59% | 11.36% | 1.61% | 2.01% | 16.86% | 04/07/2010 |
| BIB Market Price | 17.00% | 51.90% | 95.85% | 66.74% | 42.98% | 11.47% | 1.66% | 2.03% | 16.87% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/30/2025- NAV $79.79
- NAV Change $-1.68
- Market Price $79.76
- Market Price Change $-1.69
- Trading Volume (M) 13,816
- 30-Day Median Bid Ask Spread 0.25%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/30/2025- NAV $79.79
- NAV Change $-1.68
- Market Price $79.76
- Market Price Change $-1.69
- Trading Volume (M) 13,816
- 30-Day Median Bid Ask Spread 0.25%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 12/30/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 6.00% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,028,346.68 | 11,082 | 2931034 |
| 5.61% | GILD | GILEAD SCIENCES INC | -- | $4,701,780.60 | 38,170 | 2369174 |
| 5.46% | AMGN | AMGEN INC | -- | $4,570,763.14 | 13,906 | 2023607 |
| 4.21% | REGN | REGENERON PHARMACEUTICALS | -- | $3,530,714.28 | 4,562 | 2730190 |
| 2.85% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $2,385,647.88 | 25,788 | 2989044 |
| 2.77% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,317,953.75 | 5,835 | B00FWN1 |
| 1.96% | INSM | INSMED INC | -- | $1,639,927.80 | 9,420 | 2614487 |
| 1.36% | BIIB | BIOGEN INC | -- | $1,143,072.00 | 6,480 | 2455965 |
| 1.29% | ARGX | ARGENX SE - ADR | -- | $1,077,539.40 | 1,286 | BDVLM39 |
| 1.13% | UTHR | UNITED THERAPEUTICS CORP | -- | $943,753.38 | 1,902 | 2430412 |
| 1.07% | ILMN | ILLUMINA INC | -- | $895,929.75 | 6,749 | 2613990 |
| 1.02% | INCY | INCYTE CORP | -- | $857,648.61 | 8,671 | 2471950 |
| 0.88% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $735,780.29 | 18,871 | BMVP7Y0 |
| 0.84% | MEDP | MEDPACE HOLDINGS INC | -- | $707,649.40 | 1,244 | BDCBC61 |
| 0.81% | RVMD | REVOLUTION MEDICINES INC | -- | $680,302.13 | 8,539 | BL71K91 |
| 0.79% | ROIV | ROIVANT SCIENCES LTD | -- | $664,451.97 | 30,719 | BMW4NZ9 |
| 0.77% | BBIO | BRIDGEBIO PHARMA INC | -- | $642,485.76 | 8,512 | BK1KWG8 |
| 0.76% | VTRS | VIATRIS INC | -- | $637,684.08 | 50,852 | BMWS3X9 |
| 0.74% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $620,743.80 | 4,404 | 2623911 |
| 0.70% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $585,481.19 | 1,003 | BD59BS7 |
| 0.69% | SMMT | SUMMIT THERAPEUTICS INC | -- | $575,088.69 | 32,881 | BMTVQS7 |
| 0.69% | GH | GUARDANT HEALTH INC | -- | $574,828.40 | 5,714 | BFXC911 |
| 0.68% | SNY | SANOFI-ADR | -- | $569,673.12 | 11,688 | 2964557 |
| 0.68% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $567,730.08 | 2,712 | BV9G6B8 |
| 0.67% | IONS | IONIS PHARMACEUTICALS INC | -- | $564,951.38 | 7,154 | BDJ0LS6 |
| 0.63% | MRNA | MODERNA INC | -- | $524,602.91 | 17,251 | BGSXTS3 |
| 0.62% | EXEL | EXELIXIS INC | -- | $521,521.68 | 11,842 | 2576941 |
| 0.60% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $500,058.23 | 8,477 | 2437071 |
| 0.57% | RNA | AVIDITY BIOSCIENCES INC | -- | $480,158.25 | 6,655 | BMWHPY1 |
| 0.55% | TEM | TEMPUS AI INC | -- | $461,077.65 | 7,635 | BSLSJJ0 |
| 0.55% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $458,480.88 | 2,684 | B4Q5ZN4 |
| 0.51% | BNTX | BIONTECH SE-ADR | -- | $425,329.92 | 4,464 | BK6H543 |
| 0.51% | ONC | BEONE MEDICINES LTD-ADR | -- | $423,560.80 | 1,390 | BYYWPW6 |
| 0.48% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $403,432.75 | 5,999 | BYQBFJ8 |
| 0.43% | -- | ABIVAX SA ADR USD 0.01 | -- | $360,652.38 | 2,607 | -- |
| 0.42% | HALO | HALOZYME THERAPEUTICS INC | -- | $351,633.80 | 5,194 | 2975098 |
| 0.42% | CYTK | CYTOKINETICS INC | -- | $350,606.81 | 5,713 | BBBSBJ5 |
| 0.41% | -- | CARIS LIFE SCIENCES INC COMMON STOCK USD 0.001 | -- | $340,461.84 | 12,462 | -- |
| 0.40% | AXSM | AXSOME THERAPEUTICS INC | -- | $331,355.33 | 2,227 | BYZR4X4 |
| 0.39% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $328,207.10 | 1,105 | BQ721R4 |
| 0.38% | NUVL | NUVALENT INC-A | -- | $320,212.20 | 3,190 | BMVBZD3 |
| 0.38% | KRYS | KRYSTAL BIOTECH INC | -- | $317,534.28 | 1,281 | BD6JX35 |
| 0.38% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $314,728.48 | 2,948 | BF2YWG4 |
| 0.32% | PTCT | PTC THERAPEUTICS INC | -- | $270,169.74 | 3,546 | B17VCN9 |
| 0.31% | PCVX | VAXCYTE INC | -- | $262,742.26 | 5,786 | BKPVGH6 |
| 0.30% | COGT | COGENT BIOSCIENCES INC | -- | $251,562.24 | 6,777 | BLR6XK8 |
| 0.30% | KYMR | KYMERA THERAPEUTICS INC | -- | $248,265.36 | 3,178 | BMPRZV5 |
| 0.29% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $240,924.86 | 2,761 | BDCBCD8 |
| 0.27% | CRSP | CRISPR THERAPEUTICS AG | -- | $223,451.19 | 4,201 | BDHF4K6 |
| 0.24% | ALKS | ALKERMES PLC | -- | $202,901.76 | 7,296 | B3P6D26 |
| 0.24% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $200,425.46 | 2,957 | BQS9486 |
| 0.24% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $199,529.10 | 7,473 | 2713317 |
| 0.24% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $198,611.49 | 4,191 | BDD19F8 |
| 0.24% | INDV | INDIVIOR PLC | -- | $197,050.95 | 5,515 | BP0BQQ5 |
| 0.23% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $196,551.72 | 4,506 | BFZQ0L8 |
| 0.23% | IMVT | IMMUNOVANT INC | -- | $196,209.00 | 7,740 | BJRFSB7 |
| 0.23% | FOLD | AMICUS THERAPEUTICS INC | -- | $194,199.00 | 13,628 | B19FQ48 |
| 0.23% | ADMA | ADMA BIOLOGICS INC | -- | $193,000.32 | 10,512 | B9NSBM2 |
| 0.22% | APGE | APOGEE THERAPEUTICS INC | -- | $183,490.72 | 2,422 | BM9HHL5 |
| 0.21% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $178,989.50 | 2,270 | BJDX8Y8 |
| 0.21% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $178,774.40 | 13,880 | BFNF1D6 |
| 0.21% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $173,977.92 | 5,008 | BP8JSP4 |
| 0.20% | LGND | LIGAND PHARMACEUTICALS | -- | $165,283.80 | 869 | 2501578 |
| 0.19% | ACLX | ARCELLX INC | -- | $162,434.40 | 2,554 | BPCJ1Q2 |
| 0.19% | TERN | TERNS PHARMACEUTICALS INC | -- | $161,507.61 | 3,979 | BMDJ0C9 |
| 0.18% | TARS | TARSUS PHARMACEUTICALS INC | -- | $154,368.75 | 1,875 | BMH5RL1 |
| 0.18% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $151,912.80 | 5,410 | BKX9VD3 |
| 0.18% | XENE | XENON PHARMACEUTICALS INC | -- | $150,581.56 | 3,413 | BRJ3GY4 |
| 0.18% | TVTX | TRAVERE THERAPEUTICS INC | -- | $148,911.36 | 3,952 | BLFGJD5 |
| 0.18% | VCYT | VERACYTE INC | -- | $147,853.16 | 3,497 | BFTWZY0 |
| 0.18% | GRAL | GRAIL INC | -- | $146,886.60 | 1,722 | BSLSSX7 |
| 0.17% | VERA | VERA THERAPEUTICS INC | -- | $144,504.08 | 2,824 | BL55460 |
| 0.17% | CGON | CG ONCOLOGY INC | -- | $142,965.03 | 3,559 | BRBCSP4 |
| 0.17% | APLS | APELLIS PHARMACEUTICALS INC | -- | $141,041.12 | 5,588 | BYTQ6X1 |
| 0.16% | IDYA | IDEAYA BIOSCIENCES INC | -- | $133,622.72 | 3,872 | BK0VHF6 |
| 0.15% | IRON | DISC MEDICINE INC | -- | $128,175.63 | 1,667 | BMGJZJ8 |
| 0.15% | WVE | WAVE LIFE SCIENCES LTD | -- | $126,635.60 | 7,384 | BYZG9R0 |
| 0.15% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $126,371.37 | 2,533 | B72ZBG4 |
| 0.15% | BEAM | BEAM THERAPEUTICS INC | -- | $124,689.24 | 4,482 | BK6L288 |
| 0.15% | MLYS | MINERALYS THERAPEUTICS INC | -- | $124,108.00 | 3,496 | BP9N0G0 |
| 0.14% | DYN | DYNE THERAPEUTICS INC | -- | $121,113.60 | 6,308 | BN15WD1 |
| 0.14% | OCUL | OCULAR THERAPEUTIX INC | -- | $114,753.20 | 9,406 | BNZB1X8 |
| 0.14% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $114,749.04 | 4,676 | BKY5JZ8 |
| 0.13% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $110,720.06 | 6,743 | BJ5FZ74 |
| 0.13% | SYRE | SPYRE THERAPEUTICS INC | -- | $109,252.76 | 3,427 | BQBBDY8 |
| 0.13% | DNLI | DENALI THERAPEUTICS INC | -- | $106,303.98 | 6,478 | BD2B4V0 |
| 0.13% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $105,417.14 | 4,261 | BLB0YQ9 |
| 0.12% | SRPT | SAREPTA THERAPEUTICS INC | -- | $99,219.33 | 4,617 | B8DPDT7 |
| 0.12% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $97,065.58 | 4,261 | BJ62Z18 |
| 0.11% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $95,756.16 | 2,544 | BKSGZN7 |
| 0.11% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $93,342.21 | 22,711 | BM9FJ13 |
| 0.11% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $92,119.86 | 5,823 | BFWLC09 |
| 0.10% | ZYME | ZYMEWORKS INC | -- | $87,714.70 | 3,305 | BPCQZY9 |
| 0.10% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $87,093.18 | 3,474 | BMZ4LN0 |
| 0.10% | TWST | TWIST BIOSCIENCE CORP | -- | $86,772.85 | 2,699 | BGKG6G7 |
| 0.10% | ZBIO | ZENAS BIOPHARMA INC | -- | $86,731.18 | 2,371 | BQB42H3 |
| 0.10% | IBRX | IMMUNITYBIO INC | -- | $86,139.90 | 43,505 | BNSP0B8 |
| 0.10% | NRIX | NURIX THERAPEUTICS INC | -- | $85,152.54 | 4,477 | BMVLGP2 |
| 0.10% | MAZE | MAZE THERAPEUTICS INC | -- | $85,106.25 | 2,125 | BSRK699 |
| 0.10% | TXG | 10X GENOMICS INC-CLASS A | -- | $83,828.34 | 5,146 | BKS3RS7 |
| 0.10% | VCEL | VERICEL CORP | -- | $82,054.82 | 2,234 | BSBMN89 |
| 0.10% | HROW | HARROW INC | -- | $81,832.72 | 1,636 | BHNDW86 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $81,775.05 | 1,995 | BRXB0C0 |
| 0.10% | SION | SIONNA THERAPEUTICS INC | -- | $81,579.69 | 1,971 | BQKXDX4 |
| 0.10% | GMAB | GENMAB A/S -SP ADR | -- | $81,307.18 | 2,582 | BBC9WC7 |
| 0.10% | STOK | STOKE THERAPEUTICS INC | -- | $80,281.86 | 2,523 | BJQ05Z6 |
| 0.10% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $80,070.07 | 3,719 | BMX9K07 |
| 0.10% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $79,724.19 | 5,187 | BRJZSK0 |
| 0.10% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $79,620.86 | 3,839 | BN7Q7R7 |
| 0.09% | ANIP | ANI PHARMACEUTICALS INC | -- | $78,784.64 | 992 | BCDWBX6 |
| 0.09% | MNKD | MANNKIND CORP | -- | $76,766.58 | 13,563 | BF081J4 |
| 0.09% | -- | PHARVARIS NV COMMON STOCK USD 0.12 | -- | $74,261.25 | 2,829 | -- |
| 0.09% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $71,230.34 | 9,299 | 2100362 |
| 0.08% | TRVI | TREVI THERAPEUTICS INC | -- | $71,139.84 | 5,664 | BJH9ZN0 |
| 0.08% | FTRE | FORTREA HOLDINGS INC | -- | $70,927.78 | 4,081 | BRXYZ57 |
| 0.08% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $70,402.08 | 2,576 | BCBVTX1 |
| 0.08% | ALVO | ALVOTECH SA | -- | $69,821.30 | 13,826 | BPNTJ34 |
| 0.08% | TSHA | TAYSHA GENE THERAPIES INC | -- | $68,480.34 | 12,099 | BNC1BX1 |
| 0.08% | PGEN | PRECIGEN INC | -- | $66,426.18 | 15,593 | BKM5C84 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $65,793.48 | 1,396 | BX7RSN3 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $65,710.70 | 1,927 | BLCD809 |
| 0.08% | INVA | INNOVIVA INC | -- | $65,696.67 | 3,303 | BDDXF67 |
| 0.08% | KOD | KODIAK SCIENCES INC | -- | $65,486.85 | 2,343 | BFXC933 |
| 0.08% | EYPT | EYEPOINT INC | -- | $65,423.73 | 3,657 | BMGS7L1 |
| 0.08% | QURE | UNIQURE NV | -- | $65,418.78 | 2,751 | BJFSR88 |
| 0.08% | NVCR | NOVOCURE LTD | -- | $65,386.12 | 4,946 | BYSS4X4 |
| 0.08% | UPB | UPSTREAM BIO INC | -- | $65,212.84 | 2,387 | BRCFFK6 |
| 0.08% | RAPP | RAPPORT THERAPEUTICS INC | -- | $64,547.95 | 2,107 | BR3T9B6 |
| 0.08% | RLAY | RELAY THERAPEUTICS INC | -- | $63,919.25 | 7,655 | BN2R582 |
| 0.08% | ATAI | ATAI LIFE SCIENCES NV | -- | $63,847.16 | 16,042 | BN6M8F1 |
| 0.07% | ORKA | ORUKA THERAPEUTICS INC | -- | $62,258.56 | 2,138 | BKVF0J2 |
| 0.07% | ARDX | ARDELYX INC | -- | $62,245.60 | 10,732 | BN89V40 |
| 0.07% | MBX | MBX BIOSCIENCES INC | -- | $61,274.70 | 1,983 | BQXJKH2 |
| 0.07% | TYRA | TYRA BIOSCIENCES INC | -- | $59,962.08 | 2,357 | BMVNDH9 |
| 0.07% | ANAB | ANAPTYSBIO INC | -- | $58,985.29 | 1,223 | BDRW1L7 |
| 0.07% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $58,212.00 | 4,851 | BPCK358 |
| 0.07% | MNMD | MIND MEDICINE MINDMED INC | -- | $56,345.45 | 4,351 | BPQYY97 |
| 0.07% | SEPN | SEPTERNA INC | -- | $54,948.84 | 1,978 | BQNKXX2 |
| 0.07% | SVRA | SAVARA INC | -- | $54,910.57 | 8,987 | BYXGN81 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $54,810.00 | 2,030 | BNFWZS4 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $53,574.99 | 7,329 | BLR7H87 |
| 0.06% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $53,162.64 | 3,142 | BJLKVS6 |
| 0.06% | OMER | OMEROS CORP | -- | $53,118.72 | 3,132 | B4NB858 |
| 0.06% | TNGX | TANGO THERAPEUTICS INC | -- | $51,339.87 | 5,949 | BP2P6L0 |
| 0.06% | SPRY | ARS PHARMACEUTICALS INC | -- | $50,820.24 | 4,366 | BMCR7V2 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $50,670.59 | 1,289 | BKLCWZ3 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $50,063.16 | 642 | BNSP8K3 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $49,569.60 | 5,388 | B8K7T65 |
| 0.06% | PCRX | PACIRA BIOSCIENCES INC | -- | $49,533.00 | 1,900 | B3X26D8 |
| 0.06% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $48,569.18 | 17,534 | BF0DMK7 |
| 0.06% | NVAX | NOVAVAX INC | -- | $48,229.44 | 7,177 | BJDQXG4 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $48,001.20 | 11,765 | BMFJJ97 |
| 0.06% | URGN | UROGEN PHARMA LTD | -- | $47,915.56 | 2,068 | BZ7PJQ1 |
| 0.06% | XNCR | XENCOR INC | -- | $47,404.62 | 3,154 | BGCYWN8 |
| 0.06% | NTLA | INTELLIA THERAPEUTICS INC | -- | $46,305.66 | 5,111 | BYZM6C2 |
| 0.05% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $45,929.72 | 2,876 | BP7KZP7 |
| 0.05% | ABCL | ABCELLERA BIOLOGICS INC | -- | $45,678.00 | 13,240 | BL53SR3 |
| 0.05% | ERAS | ERASCA INC | -- | $44,359.74 | 12,531 | BNLYBF3 |
| 0.05% | CRMD | CORMEDIX INC | -- | $43,430.40 | 3,480 | BJ0LT31 |
| 0.05% | ALMS | ALUMIS INC | -- | $42,424.72 | 4,294 | BPLQG36 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $42,339.49 | 2,239 | BMNDK09 |
| 0.05% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $41,392.62 | 4,509 | BLB0YH0 |
| 0.05% | -- | RAPT THERAPEUTICS INC | -- | $40,857.12 | 1,224 | BTJZB49 |
| 0.05% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $40,756.55 | 2,621 | BMFD115 |
| 0.05% | MESO | MESOBLAST LTD- SPON ADR | -- | $40,244.28 | 2,166 | BQS7491 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $39,246.90 | 8,495 | BZ0QMB7 |
| 0.05% | KURA | KURA ONCOLOGY INC | -- | $39,203.92 | 3,836 | BYZD465 |
| 0.05% | BCAX | BICARA THERAPEUTICS INC | -- | $39,010.40 | 2,420 | BQB42F1 |
| 0.05% | ESPR | ESPERION THERAPEUTICS INC | -- | $38,962.71 | 10,559 | BBNBTD2 |
| 0.05% | GERN | GERON CORP | -- | $37,782.64 | 28,196 | 2370381 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $37,772.56 | 1,823 | BMGTLY5 |
| 0.04% | JANX | JANUX THERAPEUTICS INC | -- | $36,746.31 | 2,657 | BMFX8Y7 |
| 0.04% | VIR | VIR BIOTECHNOLOGY INC | -- | $35,886.80 | 6,145 | BK4PZ38 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $35,013.44 | 2,233 | BD06CS0 |
| 0.04% | ORIC | ORIC PHARMACEUTICALS INC | -- | $34,760.16 | 4,302 | BKVDFF7 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $34,381.82 | 5,389 | BYVQJ96 |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $34,349.66 | 802 | BQD3J33 |
| 0.04% | -- | GH RESEARCH PLC COMMON STOCK USD 0.01 | -- | $34,250.00 | 2,740 | -- |
| 0.04% | REPL | REPLIMUNE GROUP INC | -- | $34,026.30 | 3,465 | BDDVW37 |
| 0.04% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $33,871.53 | 903 | BL95N25 |
| 0.04% | ARVN | ARVINAS INC | -- | $33,278.01 | 2,837 | BDZ30Q0 |
| 0.04% | ANNX | ANNEXON INC | -- | $32,220.72 | 6,393 | BMVV9R5 |
| 0.04% | GOSS | GOSSAMER BIO INC | -- | $31,895.76 | 10,223 | BJ0CK86 |
| 0.04% | RGNX | REGENXBIO INC | -- | $31,505.24 | 2,236 | BZ0G875 |
| 0.04% | LXEO | LEXEO THERAPEUTICS INC | -- | $31,401.76 | 3,224 | BQ6C357 |
| 0.04% | PSNL | PERSONALIS INC | -- | $31,226.46 | 3,918 | BJQ0608 |
| 0.04% | CTMX | CYTOMX THERAPEUTICS INC | -- | $31,133.44 | 7,484 | BYWVTY5 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $30,482.27 | 1,729 | BD9GVY0 |
| 0.04% | IVVD | INVIVYD INC | -- | $29,743.20 | 12,240 | BM8NHS1 |
| 0.04% | LYEL | LYELL IMMUNOPHARMA INC | -- | $29,599.83 | 937 | BTNMG41 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $27,977.85 | 3,555 | BFYQFJ2 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $27,968.64 | 4,162 | BMC3HS7 |
| 0.03% | VTYX | VENTYX BIOSCIENCES INC | -- | $27,580.00 | 3,152 | BMG99Y1 |
| 0.03% | PRME | PRIME MEDICINE INC | -- | $27,427.12 | 7,973 | BPBJFM7 |
| 0.03% | KROS | KEROS THERAPEUTICS INC | -- | $27,283.42 | 1,346 | BM7V485 |
| 0.03% | FULC | FULCRUM THERAPEUTICS INC | -- | $27,102.60 | 2,390 | BJDX8Z9 |
| 0.03% | CGEM | CULLINAN THERAPEUTICS INC | -- | $25,881.28 | 2,609 | BM90J52 |
| 0.03% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $24,709.51 | 3,299 | BYP80F1 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $24,631.64 | 2,516 | BMFK3H6 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $23,926.05 | 7,185 | B3MZ6K5 |
| 0.03% | ABSI | ABSCI CORP | -- | $23,180.58 | 6,642 | BN94K69 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $23,069.55 | 13,335 | B4N8MH9 |
| 0.03% | LENZ | LENZ THERAPEUTICS INC | -- | $22,277.84 | 1,382 | BQV0J03 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $22,139.18 | 2,378 | B91XRN2 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $21,910.47 | 2,487 | BLFBZ32 |
| 0.03% | BIOA | BIOAGE LABS INC | -- | $21,589.92 | 1,584 | BT9K6D8 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $20,947.62 | 6,406 | BMCWKZ2 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $20,837.79 | 639 | B292NQ7 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $20,272.50 | 1,275 | B9L5200 |
| 0.02% | ETON | ETON PHARMACEUTICALS INC | -- | $19,896.15 | 1,185 | BGL0JK3 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $19,613.70 | 3,441 | BQHN6C7 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $19,515.71 | 3,163 | 2107437 |
| 0.02% | PEPG | PEPGEN INC | -- | $19,497.54 | 3,037 | BMTX3D7 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $19,193.96 | 2,852 | BMVBZF5 |
| 0.02% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $19,131.92 | 2,524 | BKLXFX5 |
| 0.02% | EOLS | EVOLUS INC | -- | $19,096.21 | 2,863 | BDRJH21 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $18,348.30 | 2,610 | B12W3P6 |
| 0.02% | IMAB | I-MAB-SPONSORED ADR | -- | $18,184.32 | 4,592 | BKRRKY7 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $18,129.65 | 1,939 | BSMLR16 |
| 0.02% | KMDA | KAMADA LTD | -- | $18,116.28 | 2,548 | B2Q9833 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $17,454.20 | 8,860 | BFMLGR4 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $17,358.73 | 827 | BPBPCG8 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $17,031.92 | 1,688 | BP81RK8 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $16,638.49 | 4,609 | BFY7DC4 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $16,347.60 | 4,780 | BDFKQ07 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $15,399.45 | 2,805 | BP81R42 |
| 0.02% | NGNE | NEUROGENE INC | -- | $15,123.24 | 684 | BS2F741 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $14,994.80 | 3,946 | BYTYP72 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $14,779.80 | 3,780 | BMXNGZ6 |
| 0.02% | -- | JYONG BIOTECH LTD COMMON STOCK USD 0.00001 | -- | $14,170.76 | 3,358 | -- |
| 0.02% | ACIU | AC IMMUNE SA | -- | $13,970.25 | 4,435 | BZC0D70 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $13,899.20 | 2,044 | BKDQKM6 |
| 0.02% | ACRS | ACLARIS THERAPEUTICS INC | -- | $13,879.40 | 4,786 | BYV2W40 |
| 0.02% | CADL | CANDEL THERAPEUTICS INC | -- | $13,846.75 | 2,425 | BP0TQC5 |
| 0.02% | LFCR | LIFECORE BIOMEDICAL INC | -- | $13,388.95 | 1,655 | 2517058 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $13,378.26 | 2,226 | B7F2TY6 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $13,062.60 | 7,380 | BN4JN37 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $13,003.06 | 9,926 | BFZNYB7 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $12,864.70 | 2,498 | BMF7DT9 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $12,755.10 | 2,074 | BL5B6Z1 |
| 0.02% | AARD | AARDVARK THERAPEUTICS INC | -- | $12,722.45 | 962 | BTXQTX3 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $12,251.05 | 3,451 | BLN9Z50 |
| 0.01% | OABI | OMNIAB INC | -- | $11,825.88 | 6,358 | BN13S71 |
| 0.01% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $11,628.00 | 1,020 | BPRBTY7 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $10,325.16 | 2,494 | BPRB2N7 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $10,267.64 | 2,606 | BY7RB53 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $9,587.07 | 8,637 | BNR5QT9 |
| 0.01% | -- | VOR BIOPHARMA INC COMMON STOCK USD 0.0001 | -- | $9,322.32 | 744 | -- |
| 0.01% | CABA | CABALETTA BIO INC | -- | $9,141.80 | 4,252 | BK5MWR1 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $9,006.84 | 2,364 | BP7L561 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $8,796.48 | 4,312 | BZ8FPH3 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $8,390.76 | 4,281 | BKX9NQ0 |
| 0.01% | HUMA | HUMACYTE INC | -- | $8,354.72 | 8,272 | BMYTJP4 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $8,008.65 | 1,369 | BP2NYN2 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $7,768.45 | 1,255 | BKC9SX3 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $7,527.99 | 5,339 | BRK0149 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $6,563.52 | 4,128 | BNYJR68 |
| 0.01% | CDXS | CODEXIS INC | -- | $6,384.00 | 3,990 | B5LL2C2 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $6,267.33 | 2,517 | BKTV702 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $5,815.80 | 4,308 | BNNXX18 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $5,147.80 | 7,354 | BNNXX52 |
| -- | PYXS | PYXIS ONCOLOGY INC | -- | $2,997.50 | 2,750 | BLBR8D5 |
| -- | -- | SUTRO BIOPHARMA INC COMMON STOCK USD 0.001 | -- | $11.67 | 01 | -- |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| 35.68% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 29,894,576 | -- | 5,238 | -- |
| 33.23% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 27,839,966 | -- | 4,878 | -- |
| 24.01% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 20,118,056 | -- | 3,525 | -- |
| 16.92% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,176,809 | -- | 2,484 | -- |
| 15.66% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 13,120,968 | -- | 2,299 | -- |
| 4.31% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,612,689 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $24,889,942.83 | 24,889,943 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
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Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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