BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 9/30/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 11/06/2025- NAV $70.26
- NAV Change $+0.03
- Market Price $70.25
- Market Price Change $+0.05
- Trading Volume (M) 8,811
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 11/06/2025- NAV $70.26
- NAV Change $+0.03
- Market Price $70.25
- Market Price Change $+0.05
- Trading Volume (M) 8,811
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 11/06/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.01% | AMGN | AMGEN INC | -- | $3,417,524.11 | 10,829 | 2023607 |
| 4.99% | GILD | GILEAD SCIENCES INC | -- | $3,403,372.00 | 27,580 | 2369174 |
| 4.87% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $3,316,680.00 | 7,968 | 2931034 |
| 3.69% | REGN | REGENERON PHARMACEUTICALS | -- | $2,516,324.30 | 3,890 | 2730190 |
| 3.16% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,156,198.55 | 4,895 | B00FWN1 |
| 2.40% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $1,633,347.46 | 19,498 | 2989044 |
| 2.17% | INSM | INSMED INC | -- | $1,477,827.12 | 7,959 | 2614487 |
| 1.44% | ARGX | ARGENX SE - ADR | -- | $981,220.30 | 1,153 | BDVLM39 |
| 1.27% | BIIB | BIOGEN INC | -- | $865,204.80 | 5,520 | 2455965 |
| 1.14% | INCY | INCYTE CORP | -- | $773,535.60 | 7,353 | 2471950 |
| 1.13% | UTHR | UNITED THERAPEUTICS CORP | -- | $773,162.00 | 1,703 | 2430412 |
| 1.03% | ILMN | ILLUMINA INC | -- | $700,863.57 | 5,787 | 2613990 |
| 0.97% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $663,776.06 | 16,277 | BMVP7Y0 |
| 0.92% | MEDP | MEDPACE HOLDINGS INC | -- | $625,944.83 | 1,057 | BDCBC61 |
| 0.85% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $578,023.20 | 3,734 | 2623911 |
| 0.78% | ROIV | ROIVANT SCIENCES LTD | -- | $528,895.84 | 25,712 | BMW4NZ9 |
| 0.76% | SMMT | SUMMIT THERAPEUTICS INC | -- | $516,028.05 | 27,969 | BMTVQS7 |
| 0.73% | SNY | SANOFI-ADR | -- | $499,947.98 | 10,102 | 2964557 |
| 0.67% | TEM | TEMPUS AI INC | -- | $457,915.68 | 6,352 | BSLSJJ0 |
| 0.67% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $456,550.48 | 2,291 | BV9G6B8 |
| 0.66% | GH | GUARDANT HEALTH INC | -- | $451,893.75 | 4,695 | BFXC911 |
| 0.66% | BBIO | BRIDGEBIO PHARMA INC | -- | $451,530.54 | 7,198 | BK1KWG8 |
| 0.65% | IONS | IONIS PHARMACEUTICALS INC | -- | $444,748.20 | 6,002 | BDJ0LS6 |
| 0.65% | VTRS | VIATRIS INC | -- | $443,798.67 | 43,897 | BMWS3X9 |
| 0.63% | RVMD | REVOLUTION MEDICINES INC | -- | $432,053.82 | 7,039 | BL71K91 |
| 0.62% | ONC | BEONE MEDICINES LTD-ADR | -- | $420,435.40 | 1,265 | BYYWPW6 |
| 0.61% | EXEL | EXELIXIS INC | -- | $413,548.80 | 10,136 | 2576941 |
| 0.60% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $409,918.62 | 839 | BD59BS7 |
| 0.57% | BNTX | BIONTECH SE-ADR | -- | $391,386.45 | 3,787 | BK6H543 |
| 0.55% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $374,803.20 | 7,230 | 2437071 |
| 0.52% | MRNA | MODERNA INC | -- | $356,410.17 | 14,649 | BGSXTS3 |
| 0.50% | RNA | AVIDITY BIOSCIENCES INC | -- | $338,014.32 | 4,844 | BMWHPY1 |
| 0.45% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $306,170.20 | 2,284 | B4Q5ZN4 |
| 0.44% | HALO | HALOZYME THERAPEUTICS INC | -- | $301,189.56 | 4,404 | 2975098 |
| 0.40% | CYTK | CYTOKINETICS INC | -- | $271,651.50 | 4,505 | BBBSBJ5 |
| 0.40% | MRUS | MERUS NV | -- | $271,015.68 | 2,848 | BZBY005 |
| 0.38% | AXSM | AXSOME THERAPEUTICS INC | -- | $261,811.98 | 1,878 | BYZR4X4 |
| 0.36% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $246,323.49 | 2,501 | BF2YWG4 |
| 0.35% | NUVL | NUVALENT INC-A | -- | $240,633.70 | 2,510 | BMVBZD3 |
| 0.32% | KRYS | KRYSTAL BIOTECH INC | -- | $217,967.30 | 1,090 | BD6JX35 |
| 0.32% | PTCT | PTC THERAPEUTICS INC | -- | $217,116.69 | 2,991 | B17VCN9 |
| 0.30% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $206,118.00 | 5,205 | BYQBFJ8 |
| 0.30% | PCVX | VAXCYTE INC | -- | $203,878.48 | 4,888 | BKPVGH6 |
| 0.29% | ALKS | ALKERMES PLC | -- | $196,922.88 | 6,216 | B3P6D26 |
| 0.28% | CRSP | CRISPR THERAPEUTICS AG | -- | $193,832.64 | 3,424 | BDHF4K6 |
| 0.27% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $186,844.76 | 2,342 | BDCBCD8 |
| 0.27% | ACLX | ARCELLX INC | -- | $184,161.60 | 2,088 | BPCJ1Q2 |
| 0.24% | KYMR | KYMERA THERAPEUTICS INC | -- | $164,212.00 | 2,692 | BMPRZV5 |
| 0.24% | AKRO | AKERO THERAPEUTICS INC | -- | $162,376.92 | 3,012 | BK7Y2V9 |
| 0.23% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $157,129.05 | 4,241 | BP8JSP4 |
| 0.23% | IMVT | IMMUNOVANT INC | -- | $155,369.88 | 6,564 | BJRFSB7 |
| 0.23% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $154,389.50 | 3,550 | BDD19F8 |
| 0.23% | LGND | LIGAND PHARMACEUTICALS | -- | $153,666.36 | 738 | 2501578 |
| 0.22% | INDV | INDIVIOR PLC | -- | $149,693.39 | 4,697 | BP0BQQ5 |
| 0.20% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $137,879.50 | 11,825 | BFNF1D6 |
| 0.20% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $137,542.45 | 6,353 | 2713317 |
| 0.20% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $136,501.20 | 792 | BQ721R4 |
| 0.19% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $128,126.24 | 1,892 | BJDX8Y8 |
| 0.18% | ADMA | ADMA BIOLOGICS INC | -- | $126,045.52 | 8,984 | B9NSBM2 |
| 0.18% | VCYT | VERACYTE INC | -- | $123,485.78 | 2,962 | BFTWZY0 |
| 0.17% | CGON | CG ONCOLOGY INC | -- | $113,949.99 | 2,871 | BRBCSP4 |
| 0.17% | IRON | DISC MEDICINE INC | -- | $113,883.00 | 1,309 | BMGJZJ8 |
| 0.17% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $113,301.40 | 4,514 | BKX9VD3 |
| 0.16% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $112,317.55 | 3,629 | BJ62Z18 |
| 0.16% | TVTX | TRAVERE THERAPEUTICS INC | -- | $111,788.10 | 3,357 | BLFGJD5 |
| 0.16% | XENE | XENON PHARMACEUTICALS INC | -- | $111,184.90 | 2,903 | BRJ3GY4 |
| 0.16% | GRAL | GRAIL INC | -- | $108,641.42 | 1,357 | BSLSSX7 |
| 0.16% | TARS | TARSUS PHARMACEUTICALS INC | -- | $108,263.10 | 1,590 | BMH5RL1 |
| 0.15% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $104,256.00 | 3,620 | BFZQ0L8 |
| 0.15% | FOLD | AMICUS THERAPEUTICS INC | -- | $103,293.40 | 11,606 | B19FQ48 |
| 0.15% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $102,612.90 | 3,170 | BMX9K07 |
| 0.15% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $99,776.42 | 2,111 | B72ZBG4 |
| 0.14% | IDYA | IDEAYA BIOSCIENCES INC | -- | $98,505.00 | 3,300 | BK0VHF6 |
| 0.14% | DYN | DYNE THERAPEUTICS INC | -- | $97,524.19 | 5,357 | BN15WD1 |
| 0.14% | APGE | APOGEE THERAPEUTICS INC | -- | $95,471.32 | 1,736 | BM9HHL5 |
| 0.14% | APLS | APELLIS PHARMACEUTICALS INC | -- | $93,721.05 | 4,755 | BYTQ6X1 |
| 0.14% | MLYS | MINERALYS THERAPEUTICS INC | -- | $92,376.96 | 2,496 | BP9N0G0 |
| 0.13% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $89,205.48 | 5,733 | BJ5FZ74 |
| 0.13% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $88,198.28 | 2,188 | BCBVTX1 |
| 0.13% | BEAM | BEAM THERAPEUTICS INC | -- | $88,178.35 | 3,809 | BK6L288 |
| 0.12% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $82,480.02 | 3,612 | BLB0YQ9 |
| 0.12% | DNLI | DENALI THERAPEUTICS INC | -- | $79,327.05 | 5,505 | BD2B4V0 |
| 0.11% | COGT | COGENT BIOSCIENCES INC | -- | $77,412.48 | 5,259 | BLR6XK8 |
| 0.11% | IBRX | IMMUNITYBIO INC | -- | $75,452.92 | 35,591 | BNSP0B8 |
| 0.11% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $75,106.68 | 2,244 | BQS9486 |
| 0.11% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $74,331.18 | 16,089 | BM9FJ13 |
| 0.11% | ANIP | ANI PHARMACEUTICALS INC | -- | $73,717.91 | 817 | BCDWBX6 |
| 0.11% | VCEL | VERICEL CORP | -- | $73,625.00 | 1,900 | BSBMN89 |
| 0.10% | OCUL | OCULAR THERAPEUTIX INC | -- | $69,637.13 | 6,551 | BNZB1X8 |
| 0.10% | TWST | TWIST BIOSCIENCE CORP | -- | $69,591.36 | 2,272 | BGKG6G7 |
| 0.10% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $69,150.15 | 4,957 | BFWLC09 |
| 0.10% | AVDL | AVADEL PHARMACEUTICALS | -- | $68,385.05 | 3,655 | BDGMC59 |
| 0.10% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $67,949.84 | 3,976 | BKY5JZ8 |
| 0.10% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $67,016.04 | 2,166 | BKSGZN7 |
| 0.10% | MNKD | MANNKIND CORP | -- | $65,857.80 | 11,554 | BF081J4 |
| 0.10% | SRPT | SAREPTA THERAPEUTICS INC | -- | $64,897.56 | 3,679 | B8DPDT7 |
| 0.10% | JANX | JANUX THERAPEUTICS INC | -- | $64,828.92 | 2,262 | BMFX8Y7 |
| 0.09% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $63,237.31 | 1,637 | BRXB0C0 |
| 0.09% | VERA | VERA THERAPEUTICS INC | -- | $60,628.88 | 2,404 | BL55460 |
| 0.09% | TERN | TERNS PHARMACEUTICALS INC | -- | $60,133.75 | 3,295 | BMDJ0C9 |
| 0.09% | ALVO | ALVOTECH SA | -- | $59,632.10 | 11,785 | BPNTJ34 |
| 0.08% | QURE | UNIQURE NV | -- | $56,835.66 | 2,066 | BJFSR88 |
| 0.08% | TXG | 10X GENOMICS INC-CLASS A | -- | $56,004.00 | 4,308 | BKS3RS7 |
| 0.08% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $55,565.12 | 7,904 | 2100362 |
| 0.08% | ARDX | ARDELYX INC | -- | $51,268.10 | 9,074 | BN89V40 |
| 0.07% | ABCL | ABCELLERA BIOLOGICS INC | -- | $50,976.09 | 11,253 | BL53SR3 |
| 0.07% | SYRE | SPYRE THERAPEUTICS INC | -- | $50,937.25 | 2,275 | BQBBDY8 |
| 0.07% | ZYME | ZYMEWORKS INC | -- | $50,657.00 | 2,830 | BPCQZY9 |
| 0.07% | TRVI | TREVI THERAPEUTICS INC | -- | $50,480.85 | 4,585 | BJH9ZN0 |
| 0.07% | NTLA | INTELLIA THERAPEUTICS INC | -- | $49,785.12 | 4,041 | BYZM6C2 |
| 0.07% | INVA | INNOVIVA INC | -- | $48,836.34 | 2,373 | BDDXF67 |
| 0.07% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $48,520.85 | 4,415 | BRJZSK0 |
| 0.07% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $48,222.76 | 1,186 | BX7RSN3 |
| 0.07% | HROW | HARROW INC | -- | $47,974.92 | 1,393 | BHNDW86 |
| 0.07% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $47,645.26 | 1,508 | BLCD809 |
| 0.07% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $47,639.67 | 3,243 | BN7Q7R7 |
| 0.07% | NVCR | NOVOCURE LTD | -- | $47,435.43 | 4,209 | BYSS4X4 |
| 0.07% | WVE | WAVE LIFE SCIENCES LTD | -- | $47,216.96 | 5,992 | BYZG9R0 |
| 0.07% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $46,884.51 | 6,081 | BLR7H87 |
| 0.07% | NVAX | NOVAVAX INC | -- | $46,420.44 | 6,116 | BJDQXG4 |
| 0.07% | STOK | STOKE THERAPEUTICS INC | -- | $46,378.08 | 2,064 | BJQ05Z6 |
| 0.07% | ORIC | ORIC PHARMACEUTICALS INC | -- | $45,882.80 | 3,656 | BKVDFF7 |
| 0.07% | GMAB | GENMAB A/S -SP ADR | -- | $45,509.52 | 1,578 | BBC9WC7 |
| 0.07% | CVAC | CUREVAC NV | -- | $44,514.75 | 8,479 | BN4RD42 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $44,220.54 | 546 | BNSP8K3 |
| 0.06% | PGEN | PRECIGEN INC | -- | $43,982.40 | 11,220 | BKM5C84 |
| 0.06% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $42,402.50 | 1,750 | BNFWZS4 |
| 0.06% | RLAY | RELAY THERAPEUTICS INC | -- | $42,392.76 | 6,492 | BN2R582 |
| 0.06% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $41,840.68 | 3,358 | BPCK358 |
| 0.06% | ZLAB | ZAI LAB LTD-ADR | -- | $41,693.15 | 1,801 | BD9GVY0 |
| 0.06% | URGN | UROGEN PHARMA LTD | -- | $41,006.68 | 1,742 | BZ7PJQ1 |
| 0.06% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $40,827.30 | 2,231 | BMFD115 |
| 0.06% | TSHA | TAYSHA GENE THERAPIES INC | -- | $40,266.24 | 10,272 | BNC1BX1 |
| 0.06% | ANAB | ANAPTYSBIO INC | -- | $40,262.80 | 1,054 | BDRW1L7 |
| 0.06% | ORKA | ORUKA THERAPEUTICS INC | -- | $39,903.08 | 1,411 | BKVF0J2 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $39,455.10 | 9,742 | BMFJJ97 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $38,397.48 | 4,593 | B8K7T65 |
| 0.06% | FTRE | FORTREA HOLDINGS INC | -- | $37,633.30 | 3,415 | BRXYZ57 |
| 0.06% | XNCR | XENCOR INC | -- | $37,590.00 | 2,685 | BGCYWN8 |
| 0.05% | CSTL | CASTLE BIOSCIENCES INC | -- | $36,636.60 | 1,092 | BKLCWZ3 |
| 0.05% | NRIX | NURIX THERAPEUTICS INC | -- | $36,045.08 | 2,879 | BMVLGP2 |
| 0.05% | PCRX | PACIRA BIOSCIENCES INC | -- | $35,701.20 | 1,692 | B3X26D8 |
| 0.05% | RAPP | RAPPORT THERAPEUTICS INC | -- | $34,844.64 | 1,374 | BR3T9B6 |
| 0.05% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $34,829.84 | 2,671 | BJLKVS6 |
| 0.05% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $34,683.42 | 3,858 | BLB0YH0 |
| 0.05% | TNGX | TANGO THERAPEUTICS INC | -- | $33,553.89 | 4,189 | BP2P6L0 |
| 0.05% | KURA | KURA ONCOLOGY INC | -- | $33,213.04 | 3,269 | BYZD465 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $33,011.68 | 767 | BL95N25 |
| 0.05% | MNMD | MIND MEDICINE MINDMED INC | -- | $32,489.10 | 2,865 | BPQYY97 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $32,052.36 | 7,219 | BZ0QMB7 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $31,476.06 | 13,626 | BF0DMK7 |
| 0.04% | SPRY | ARS PHARMACEUTICALS INC | -- | $30,493.60 | 3,721 | BMCR7V2 |
| 0.04% | CRMD | CORMEDIX INC | -- | $30,302.58 | 2,811 | BJ0LT31 |
| 0.04% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $30,261.26 | 2,326 | BP7KZP7 |
| 0.04% | EYPT | EYEPOINT PHARMACEUTICALS INC | -- | $28,752.60 | 2,595 | BMGS7L1 |
| 0.04% | TYRA | TYRA BIOSCIENCES INC | -- | $28,645.68 | 2,006 | BMVNDH9 |
| 0.04% | TBPH | THERAVANCE BIOPHARMA INC | -- | $28,193.52 | 1,896 | BMNDK09 |
| 0.04% | AVBP | ARRIVENT BIOPHARMA INC | -- | $28,081.53 | 1,527 | BMGTLY5 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $27,928.28 | 4,556 | BYVQJ96 |
| 0.04% | ARVN | ARVINAS INC | -- | $27,640.00 | 2,764 | BDZ30Q0 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $27,525.30 | 6,585 | BPBJFM7 |
| 0.04% | VIR | VIR BIOTECHNOLOGY INC | -- | $26,782.72 | 5,231 | BK4PZ38 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $26,545.54 | 1,778 | BQS7491 |
| 0.04% | ATXS | ASTRIA THERAPEUTICS INC | -- | $26,413.75 | 2,125 | BMYRFN8 |
| 0.04% | GERN | GERON CORP | -- | $25,944.84 | 24,023 | 2370381 |
| 0.04% | SVRA | SAVARA INC | -- | $25,901.84 | 6,508 | BYXGN81 |
| 0.04% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $25,473.89 | 3,029 | BFYQFJ2 |
| 0.04% | REPL | REPLIMUNE GROUP INC | -- | $24,981.50 | 2,939 | BDDVW37 |
| 0.04% | KROS | KEROS THERAPEUTICS INC | -- | $24,723.93 | 1,529 | BM7V485 |
| 0.04% | LENZ | LENZ THERAPEUTICS INC | -- | $24,659.04 | 1,074 | BQV0J03 |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $24,417.12 | 676 | BQD3J33 |
| 0.04% | PSNL | PERSONALIS INC | -- | $23,990.72 | 3,339 | BJQ0608 |
| 0.04% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $23,931.60 | 3,234 | BYTYP72 |
| 0.04% | ERAS | ERASCA INC | -- | $23,927.68 | 10,682 | BNLYBF3 |
| 0.03% | SIGA | SIGA TECHNOLOGIES INC | -- | $22,042.66 | 2,698 | 2107437 |
| 0.03% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $21,942.92 | 2,806 | BYP80F1 |
| 0.03% | RGNX | REGENXBIO INC | -- | $21,245.34 | 1,902 | BZ0G875 |
| 0.03% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $21,162.96 | 2,584 | BMZ4LN0 |
| 0.03% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $20,647.44 | 1,896 | BD06CS0 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $20,432.16 | 2,027 | B91XRN2 |
| 0.03% | ABSI | ABSCI CORP | -- | $20,215.29 | 5,631 | BN94K69 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $20,131.80 | 11,310 | B4N8MH9 |
| 0.03% | LXRX | LEXICON PHARMACEUTICALS INC | -- | $19,566.69 | 13,683 | BWFZX59 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $19,302.27 | 3,453 | BMC3HS7 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $19,216.26 | 2,114 | BLFBZ32 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $19,208.28 | 1,759 | BKLXFX5 |
| 0.03% | ESPR | ESPERION THERAPEUTICS INC | -- | $18,980.00 | 7,592 | BBNBTD2 |
| 0.03% | HCM | HUTCHMED CHINA-ADR | -- | $18,045.60 | 1,168 | BYXV9H7 |
| 0.03% | EOLS | EVOLUS INC | -- | $17,490.48 | 2,436 | BDRJH21 |
| 0.03% | ALMS | ALUMIS INC | -- | $17,218.56 | 3,648 | BPLQG36 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $17,117.86 | 2,033 | BQ6C357 |
| 0.02% | OMER | OMEROS CORP | -- | $16,864.54 | 2,563 | B4NB858 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $16,816.80 | 539 | B292NQ7 |
| 0.02% | CGEM | CULLINAN THERAPEUTICS INC | -- | $16,353.75 | 2,225 | BM90J52 |
| 0.02% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $15,747.61 | 5,449 | BMCWKZ2 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $15,735.42 | 6,099 | BN4JN37 |
| 0.02% | DSGN | DESIGN THERAPEUTICS INC | -- | $14,736.15 | 2,145 | BMFK3H6 |
| 0.02% | NGNE | NEUROGENE INC | -- | $14,316.42 | 537 | BS2F741 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $13,368.96 | 704 | BPBPCG8 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $13,126.72 | 4,064 | BDFKQ07 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $13,096.56 | 3,324 | BFY7DC4 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $13,044.45 | 3,781 | BZC0D70 |
| 0.02% | LYEL | LYELL IMMUNOPHARMA INC | -- | $12,945.12 | 724 | BTNMG41 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $12,659.40 | 2,340 | BP81R42 |
| 0.02% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $12,539.85 | 6,117 | B3MZ6K5 |
| 0.02% | ANNX | ANNEXON INC | -- | $12,499.78 | 4,139 | BMVV9R5 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $12,358.38 | 2,932 | BQHN6C7 |
| 0.02% | AMRN | AMARIN CORP PLC -ADR | -- | $11,893.53 | 759 | BN72KB0 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $11,549.61 | 1,629 | BSMLR16 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $11,403.60 | 1,768 | BL5B6Z1 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $11,333.91 | 1,741 | BKDQKM6 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $11,183.81 | 3,223 | BMXNGZ6 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $10,270.72 | 7,552 | BFMLGR4 |
| 0.01% | TRDA | ENTRADA THERAPEUTICS INC | -- | $9,959.35 | 1,433 | BP81RK8 |
| 0.01% | VNDA | VANDA PHARMACEUTICALS INC | -- | $9,812.25 | 2,225 | B12W3P6 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $9,711.00 | 2,988 | BLN9Z50 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $9,692.15 | 2,015 | BP7L561 |
| 0.01% | PYXS | PYXIS ONCOLOGY INC | -- | $9,437.44 | 2,336 | BLBR8D5 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $9,108.34 | 3,386 | BZ8FPH3 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $8,815.58 | 2,089 | BY7RB53 |
| 0.01% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $8,772.75 | 8,355 | BFZNYB7 |
| 0.01% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $8,694.00 | 805 | B9L5200 |
| 0.01% | FHTX | FOGHORN THERAPEUTICS INC | -- | $8,516.00 | 2,129 | BMF7DT9 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $8,480.67 | 1,023 | BKC9SX3 |
| 0.01% | HUMA | HUMACYTE INC | -- | $7,812.84 | 5,964 | BMYTJP4 |
| 0.01% | RNAC | CARTESIAN THERAPEUTICS INC | -- | $7,391.45 | 979 | BQB9HM8 |
| 0.01% | CDXS | CODEXIS INC | -- | $6,916.97 | 3,399 | B5LL2C2 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $6,380.78 | 2,681 | BKX9NQ0 |
| 0.01% | OABI | OMNIAB INC | -- | $6,376.98 | 4,621 | BN13S71 |
| 0.01% | MXCT | MAXCYTE INC | -- | $5,902.05 | 4,015 | BKMQF66 |
| 0.01% | NKTX | NKARTA INC | -- | $5,269.75 | 2,675 | BK80YJ8 |
| 0.01% | PEPG | PEPGEN INC | -- | $5,199.35 | 1,235 | BMTX3D7 |
| 0.01% | CLYM | CLIMB BIO INC | -- | $4,976.40 | 2,552 | BMW5LX6 |
| 0.01% | ALEC | ALECTOR INC | -- | $4,955.60 | 3,812 | BJ4LDC4 |
| 0.01% | FATE | FATE THERAPEUTICS INC | -- | $4,516.72 | 4,343 | BCZS820 |
| 0.01% | APLT | APPLIED THERAPEUTICS INC | -- | $4,052.61 | 5,423 | BJL38Z1 |
| 0.01% | PLRX | PLIANT THERAPEUTICS INC | -- | $3,537.36 | 2,312 | BMDWW66 |
| 0.01% | TVGN | TEVOGEN BIO HOLDINGS INC | -- | $3,475.36 | 7,407 | BPG5P75 |
| -- | MGNX | MACROGENICS INC | -- | $3,238.16 | 2,381 | BFDV8K0 |
| -- | ARTV | ARTIVA BIOTHERAPEUTICS INC | -- | $3,164.80 | 920 | BMF1LJ7 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $3,009.39 | 3,194 | BF12XC2 |
| -- | BMEA | BIOMEA FUSION INC | -- | $2,914.60 | 2,242 | BNKF6N0 |
| -- | ACRV | ACRIVON THERAPEUTICS INC | -- | $2,370.00 | 1,185 | BP2TPK4 |
| -- | TCRX | TSCAN THERAPEUTICS INC | -- | $2,293.32 | 1,977 | BNLYBJ7 |
| -- | OKUR | ONKURE THERAPEUTICS INC-A | -- | $1,529.44 | 484 | BT7KGT6 |
| -- | MRSN | MERSANA THERAPEUTICS INC | -- | $1,519.56 | 189 | BVPKH99 |
| -- | QTTB | Q32 BIO INC | -- | $1,069.52 | 461 | BS2FKQ4 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 37.00% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 25,214,814 | -- | 4,737 | -- |
| 28.19% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 19,210,527 | -- | 3,609 | -- |
| 24.62% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 16,777,938 | -- | 3,152 | -- |
| 19.40% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 13,222,208 | -- | 2,484 | -- |
| 17.96% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 12,237,462 | -- | 2,299 | -- |
| 9.02% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 6,148,007 | -- | 1,155 | -- |
| -- | -- | TREASURY BILL | -- | $4,993,197.55 | 5,000,000 | BMGHP58 |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $19,391,372.04 | 19,391,372 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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