BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 10/31/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 20.05% | 41.93% | 51.59% | 42.58% | 20.67% | 9.55% | 2.60% | 0.91% | 15.79% | 04/07/2010 |
| BIB Market Price | 20.06% | 42.12% | 51.73% | 42.51% | 20.92% | 9.51% | 2.55% | 0.91% | 15.79% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 11/24/2025- NAV $79.90
- NAV Change $+2.26
- Market Price $79.96
- Market Price Change $+2.35
- Trading Volume (M) 31,320
- 30-Day Median Bid Ask Spread 0.28%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 11/24/2025- NAV $79.90
- NAV Change $+2.26
- Market Price $79.96
- Market Price Change $+2.35
- Trading Volume (M) 31,320
- 30-Day Median Bid Ask Spread 0.28%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 11/24/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.33% | AMGN | AMGEN INC | -- | $4,432,818.00 | 13,260 | 2023607 |
| 5.09% | GILD | GILEAD SCIENCES INC | -- | $4,230,618.44 | 33,772 | 2369174 |
| 4.98% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $4,136,544.00 | 9,756 | 2931034 |
| 4.36% | REGN | REGENERON PHARMACEUTICALS | -- | $3,626,786.35 | 4,763 | 2730190 |
| 3.13% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,602,340.39 | 5,993 | B00FWN1 |
| 2.63% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $2,184,856.96 | 23,873 | 2989044 |
| 2.43% | INSM | INSMED INC | -- | $2,016,532.85 | 9,745 | 2614487 |
| 1.54% | ARGX | ARGENX SE - ADR | -- | $1,279,410.14 | 1,411 | BDVLM39 |
| 1.44% | BIIB | BIOGEN INC | -- | $1,195,126.38 | 6,759 | 2455965 |
| 1.20% | UTHR | UNITED THERAPEUTICS CORP | -- | $994,962.00 | 2,085 | 2430412 |
| 1.15% | INCY | INCYTE CORP | -- | $956,372.48 | 9,002 | 2471950 |
| 1.07% | ILMN | ILLUMINA INC | -- | $892,552.56 | 7,086 | 2613990 |
| 0.96% | MEDP | MEDPACE HOLDINGS INC | -- | $800,944.55 | 1,295 | BDCBC61 |
| 0.95% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $792,177.75 | 19,929 | BMVP7Y0 |
| 0.78% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $645,795.00 | 4,572 | 2623911 |
| 0.77% | GH | GUARDANT HEALTH INC | -- | $639,576.25 | 5,749 | BFXC911 |
| 0.77% | ROIV | ROIVANT SCIENCES LTD | -- | $639,084.60 | 31,482 | BMW4NZ9 |
| 0.76% | RVMD | REVOLUTION MEDICINES INC | -- | $634,801.88 | 8,618 | BL71K91 |
| 0.75% | BBIO | BRIDGEBIO PHARMA INC | -- | $625,634.87 | 8,813 | BK1KWG8 |
| 0.74% | SMMT | SUMMIT THERAPEUTICS INC | -- | $610,948.64 | 34,246 | BMTVQS7 |
| 0.73% | SNY | SANOFI-ADR | -- | $608,034.65 | 12,371 | 2964557 |
| 0.73% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $606,145.52 | 1,031 | BD59BS7 |
| 0.71% | TEM | TEMPUS AI INC | -- | $591,442.56 | 7,776 | BSLSJJ0 |
| 0.70% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $585,074.97 | 2,799 | BV9G6B8 |
| 0.69% | IONS | IONIS PHARMACEUTICALS INC | -- | $576,964.96 | 7,348 | BDJ0LS6 |
| 0.68% | VTRS | VIATRIS INC | -- | $568,116.36 | 53,748 | BMWS3X9 |
| 0.63% | EXEL | EXELIXIS INC | -- | $524,322.50 | 12,410 | 2576941 |
| 0.62% | ONC | BEONE MEDICINES LTD-ADR | -- | $515,700.50 | 1,550 | BYYWPW6 |
| 0.61% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $505,796.40 | 2,796 | B4Q5ZN4 |
| 0.59% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $491,175.00 | 8,850 | 2437071 |
| 0.54% | BNTX | BIONTECH SE-ADR | -- | $447,752.52 | 4,638 | BK6H543 |
| 0.52% | MRNA | MODERNA INC | -- | $433,178.55 | 17,937 | BGSXTS3 |
| 0.51% | RNA | AVIDITY BIOSCIENCES INC | -- | $422,287.20 | 5,931 | BMWHPY1 |
| 0.48% | HALO | HALOZYME THERAPEUTICS INC | -- | $399,008.00 | 5,392 | 2975098 |
| 0.45% | CYTK | CYTOKINETICS INC | -- | $370,730.36 | 5,516 | BBBSBJ5 |
| 0.42% | AXSM | AXSOME THERAPEUTICS INC | -- | $347,911.20 | 2,301 | BYZR4X4 |
| 0.41% | NUVL | NUVALENT INC-A | -- | $336,695.22 | 3,074 | BMVBZD3 |
| 0.40% | MRUS | MERUS NV | -- | $334,577.65 | 3,487 | BZBY005 |
| 0.39% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $326,347.96 | 3,062 | BF2YWG4 |
| 0.35% | PCVX | VAXCYTE INC | -- | $294,761.25 | 5,985 | BKPVGH6 |
| 0.35% | PTCT | PTC THERAPEUTICS INC | -- | $292,337.46 | 3,662 | B17VCN9 |
| 0.34% | KRYS | KRYSTAL BIOTECH INC | -- | $286,663.26 | 1,334 | BD6JX35 |
| 0.34% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $282,113.24 | 6,374 | BYQBFJ8 |
| 0.30% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $251,494.92 | 2,868 | BDCBCD8 |
| 0.30% | COGT | COGENT BIOSCIENCES INC | -- | $248,197.60 | 6,440 | BLR6XK8 |
| 0.26% | KYMR | KYMERA THERAPEUTICS INC | -- | $216,184.64 | 3,296 | BMPRZV5 |
| 0.26% | ALKS | ALKERMES PLC | -- | $214,602.00 | 7,610 | B3P6D26 |
| 0.26% | CRSP | CRISPR THERAPEUTICS AG | -- | $214,532.50 | 4,186 | BDHF4K6 |
| 0.25% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $204,097.52 | 5,192 | BP8JSP4 |
| 0.24% | ADMA | ADMA BIOLOGICS INC | -- | $201,538.32 | 11,001 | B9NSBM2 |
| 0.24% | AKRO | AKERO THERAPEUTICS INC | -- | $200,479.68 | 3,688 | BK7Y2V9 |
| 0.23% | ACLX | ARCELLX INC | -- | $191,672.72 | 2,557 | BPCJ1Q2 |
| 0.23% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $190,353.28 | 4,342 | BDD19F8 |
| 0.23% | INDV | INDIVIOR PLC | -- | $189,700.96 | 5,752 | BP0BQQ5 |
| 0.23% | IMVT | IMMUNOVANT INC | -- | $187,399.52 | 8,036 | BJRFSB7 |
| 0.22% | LGND | LIGAND PHARMACEUTICALS | -- | $186,821.67 | 903 | 2501578 |
| 0.22% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $185,894.20 | 7,778 | 2713317 |
| 0.22% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $185,213.28 | 4,432 | BFZQ0L8 |
| 0.22% | GRAL | GRAIL INC | -- | $185,146.80 | 1,662 | BSLSSX7 |
| 0.22% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $185,129.35 | 970 | BQ721R4 |
| 0.21% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $175,919.85 | 14,479 | BFNF1D6 |
| 0.20% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $169,918.24 | 5,524 | BKX9VD3 |
| 0.20% | VCYT | VERACYTE INC | -- | $169,380.90 | 3,627 | BFTWZY0 |
| 0.20% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $167,215.20 | 2,316 | BJDX8Y8 |
| 0.19% | TARS | TARSUS PHARMACEUTICALS INC | -- | $159,786.06 | 1,946 | BMH5RL1 |
| 0.18% | CGON | CG ONCOLOGY INC | -- | $153,113.40 | 3,515 | BRBCSP4 |
| 0.18% | IRON | DISC MEDICINE INC | -- | $150,670.11 | 1,601 | BMGJZJ8 |
| 0.18% | XENE | XENON PHARMACEUTICALS INC | -- | $149,487.75 | 3,555 | BRJ3GY4 |
| 0.18% | TVTX | TRAVERE THERAPEUTICS INC | -- | $147,061.11 | 4,109 | BLFGJD5 |
| 0.18% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $145,641.54 | 4,443 | BJ62Z18 |
| 0.17% | APGE | APOGEE THERAPEUTICS INC | -- | $144,249.10 | 2,126 | BM9HHL5 |
| 0.17% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $143,629.20 | 7,020 | BJ5FZ74 |
| 0.17% | DYN | DYNE THERAPEUTICS INC | -- | $142,111.86 | 6,558 | BN15WD1 |
| 0.17% | FOLD | AMICUS THERAPEUTICS INC | -- | $140,536.90 | 14,210 | B19FQ48 |
| 0.17% | IDYA | IDEAYA BIOSCIENCES INC | -- | $140,066.80 | 4,040 | BK0VHF6 |
| 0.16% | MLYS | MINERALYS THERAPEUTICS INC | -- | $130,185.60 | 3,056 | BP9N0G0 |
| 0.16% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $129,844.77 | 4,421 | BLB0YQ9 |
| 0.15% | DNLI | DENALI THERAPEUTICS INC | -- | $127,607.13 | 6,741 | BD2B4V0 |
| 0.14% | APLS | APELLIS PHARMACEUTICALS INC | -- | $117,196.86 | 5,822 | BYTQ6X1 |
| 0.14% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $116,712.75 | 2,585 | B72ZBG4 |
| 0.14% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $114,042.36 | 4,857 | BKY5JZ8 |
| 0.14% | TERN | TERNS PHARMACEUTICALS INC | -- | $112,973.16 | 4,029 | BMDJ0C9 |
| 0.13% | BEAM | BEAM THERAPEUTICS INC | -- | $110,163.68 | 4,664 | BK6L288 |
| 0.13% | TXG | 10X GENOMICS INC-CLASS A | -- | $106,165.62 | 5,274 | BKS3RS7 |
| 0.13% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $105,396.30 | 3,882 | BMX9K07 |
| 0.12% | AVDL | AVADEL PHARMACEUTICALS | -- | $102,589.92 | 4,476 | BDGMC59 |
| 0.12% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $97,755.48 | 6,068 | BFWLC09 |
| 0.12% | OCUL | OCULAR THERAPEUTIX INC | -- | $97,054.10 | 8,021 | BNZB1X8 |
| 0.12% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $96,969.10 | 2,747 | BQS9486 |
| 0.11% | IBRX | IMMUNITYBIO INC | -- | $93,690.55 | 43,577 | BNSP0B8 |
| 0.11% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $93,536.04 | 2,652 | BKSGZN7 |
| 0.11% | VCEL | VERICEL CORP | -- | $90,434.88 | 2,326 | BSBMN89 |
| 0.11% | JANX | JANUX THERAPEUTICS INC | -- | $87,338.10 | 2,770 | BMFX8Y7 |
| 0.10% | ZYME | ZYMEWORKS INC | -- | $86,590.35 | 3,465 | BPCQZY9 |
| 0.10% | VERA | VERA THERAPEUTICS INC | -- | $86,024.08 | 2,942 | BL55460 |
| 0.10% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $85,301.00 | 19,700 | BM9FJ13 |
| 0.10% | SRPT | SAREPTA THERAPEUTICS INC | -- | $85,189.55 | 4,505 | B8DPDT7 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $84,107.88 | 2,004 | BRXB0C0 |
| 0.10% | TWST | TWIST BIOSCIENCE CORP | -- | $81,625.39 | 2,783 | BGKG6G7 |
| 0.10% | ANIP | ANI PHARMACEUTICALS INC | -- | $80,980.00 | 1,000 | BCDWBX6 |
| 0.10% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $79,258.20 | 3,164 | BMZ4LN0 |
| 0.09% | ALVO | ALVOTECH SA | -- | $78,932.10 | 14,430 | BPNTJ34 |
| 0.09% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $78,466.96 | 3,971 | BN7Q7R7 |
| 0.09% | STOK | STOKE THERAPEUTICS INC | -- | $76,638.84 | 2,526 | BJQ05Z6 |
| 0.09% | SYRE | SPYRE THERAPEUTICS INC | -- | $75,111.45 | 2,785 | BQBBDY8 |
| 0.09% | MNKD | MANNKIND CORP | -- | $72,563.85 | 14,145 | BF081J4 |
| 0.09% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $71,421.74 | 1,846 | BLCD809 |
| 0.09% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $71,099.16 | 2,684 | BCBVTX1 |
| 0.08% | QURE | UNIQURE NV | -- | $70,255.62 | 2,529 | BJFSR88 |
| 0.08% | HROW | HARROW INC | -- | $66,534.00 | 1,706 | BHNDW86 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $66,174.90 | 1,452 | BX7RSN3 |
| 0.08% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $66,100.74 | 9,678 | 2100362 |
| 0.08% | RLAY | RELAY THERAPEUTICS INC | -- | $64,935.16 | 7,948 | BN2R582 |
| 0.08% | NVCR | NOVOCURE LTD | -- | $64,579.62 | 5,154 | BYSS4X4 |
| 0.08% | TRVI | TREVI THERAPEUTICS INC | -- | $64,055.74 | 5,614 | BJH9ZN0 |
| 0.07% | INVA | INNOVIVA INC | -- | $61,847.45 | 2,905 | BDDXF67 |
| 0.07% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $61,844.64 | 5,406 | BRJZSK0 |
| 0.07% | ARDX | ARDELYX INC | -- | $61,105.00 | 11,110 | BN89V40 |
| 0.07% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $60,880.56 | 4,108 | BPCK358 |
| 0.07% | NRIX | NURIX THERAPEUTICS INC | -- | $60,402.30 | 3,522 | BMVLGP2 |
| 0.07% | GMAB | GENMAB A/S -SP ADR | -- | $59,575.06 | 1,933 | BBC9WC7 |
| 0.07% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $59,453.87 | 2,731 | BMFD115 |
| 0.07% | URGN | UROGEN PHARMA LTD | -- | $57,441.69 | 2,133 | BZ7PJQ1 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $57,239.53 | 2,143 | BNFWZS4 |
| 0.07% | TSHA | TAYSHA GENE THERAPIES INC | -- | $55,585.92 | 12,576 | BNC1BX1 |
| 0.07% | XNCR | XENCOR INC | -- | $55,041.12 | 3,288 | BGCYWN8 |
| 0.07% | WVE | WAVE LIFE SCIENCES LTD | -- | $54,734.02 | 7,337 | BYZG9R0 |
| 0.07% | TYRA | TYRA BIOSCIENCES INC | -- | $54,692.82 | 2,457 | BMVNDH9 |
| 0.07% | ANAB | ANAPTYSBIO INC | -- | $54,157.45 | 1,291 | BDRW1L7 |
| 0.07% | INBX | INHIBRX BIOSCIENCES INC | -- | $54,114.68 | 668 | BNSP8K3 |
| 0.06% | CVAC | CUREVAC NV | -- | $53,041.80 | 10,380 | BN4RD42 |
| 0.06% | TNGX | TANGO THERAPEUTICS INC | -- | $52,982.57 | 5,129 | BP2P6L0 |
| 0.06% | ORIC | ORIC PHARMACEUTICALS INC | -- | $52,783.83 | 4,477 | BKVDFF7 |
| 0.06% | PGEN | PRECIGEN INC | -- | $52,475.34 | 13,737 | BKM5C84 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $52,405.76 | 7,444 | BLR7H87 |
| 0.06% | ORKA | ORUKA THERAPEUTICS INC | -- | $51,585.49 | 1,727 | BKVF0J2 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $51,461.13 | 1,337 | BKLCWZ3 |
| 0.06% | FTRE | FORTREA HOLDINGS INC | -- | $50,022.70 | 4,186 | BRXYZ57 |
| 0.06% | NVAX | NOVAVAX INC | -- | $49,645.44 | 7,488 | BJDQXG4 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $49,180.32 | 13,776 | BL53SR3 |
| 0.06% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $48,476.22 | 3,271 | BJLKVS6 |
| 0.06% | PCRX | PACIRA BIOSCIENCES INC | -- | $47,964.36 | 2,071 | B3X26D8 |
| 0.06% | RAPP | RAPPORT THERAPEUTICS INC | -- | $47,662.56 | 1,683 | BR3T9B6 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $47,016.64 | 5,624 | B8K7T65 |
| 0.06% | KURA | KURA ONCOLOGY INC | -- | $46,931.73 | 4,001 | BYZD465 |
| 0.06% | EYPT | EYEPOINT PHARMACEUTICALS INC | -- | $45,763.20 | 3,178 | BMGS7L1 |
| 0.05% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $44,868.72 | 2,847 | BP7KZP7 |
| 0.05% | ZLAB | ZAI LAB LTD-ADR | -- | $43,925.72 | 2,204 | BD9GVY0 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $42,957.00 | 2,322 | BMNDK09 |
| 0.05% | SANA | SANA BIOTECHNOLOGY INC | -- | $42,218.04 | 11,926 | BMFJJ97 |
| 0.05% | LENZ | LENZ THERAPEUTICS INC | -- | $42,001.10 | 1,315 | BQV0J03 |
| 0.05% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $41,931.36 | 4,722 | BLB0YH0 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $41,705.00 | 16,682 | BF0DMK7 |
| 0.05% | SVRA | SAVARA INC | -- | $41,513.28 | 7,968 | BYXGN81 |
| 0.05% | NTLA | INTELLIA THERAPEUTICS INC | -- | $41,324.15 | 4,949 | BYZM6C2 |
| 0.05% | MNMD | MIND MEDICINE MINDMED INC | -- | $41,289.50 | 3,514 | BPQYY97 |
| 0.05% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $41,184.60 | 827 | BQD3J33 |
| 0.05% | PSNL | PERSONALIS INC | -- | $40,839.12 | 4,088 | BJQ0608 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $40,452.12 | 939 | BL95N25 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $40,223.70 | 1,870 | BMGTLY5 |
| 0.05% | ARVN | ARVINAS INC | -- | $39,841.45 | 3,385 | BDZ30Q0 |
| 0.05% | VIR | VIR BIOTECHNOLOGY INC | -- | $39,192.48 | 6,404 | BK4PZ38 |
| 0.05% | ERAS | ERASCA INC | -- | $37,792.53 | 13,077 | BNLYBF3 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $37,733.99 | 8,837 | BZ0QMB7 |
| 0.04% | SPRY | ARS PHARMACEUTICALS INC | -- | $36,584.68 | 4,556 | BMCR7V2 |
| 0.04% | CGEM | CULLINAN THERAPEUTICS INC | -- | $35,208.39 | 2,723 | BM90J52 |
| 0.04% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $34,617.50 | 13,847 | B4N8MH9 |
| 0.04% | GERN | GERON CORP | -- | $34,119.08 | 29,413 | 2370381 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $34,004.74 | 2,177 | BQS7491 |
| 0.04% | CRMD | CORMEDIX INC | -- | $33,790.62 | 3,441 | BJ0LT31 |
| 0.04% | REPL | REPLIMUNE GROUP INC | -- | $33,785.22 | 3,598 | BDDVW37 |
| 0.04% | ALMS | ALUMIS INC | -- | $32,601.80 | 4,466 | BPLQG36 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $32,235.06 | 5,577 | BYVQJ96 |
| 0.04% | ATXS | ASTRIA THERAPEUTICS INC | -- | $32,134.70 | 2,602 | BMYRFN8 |
| 0.04% | KROS | KEROS THERAPEUTICS INC | -- | $31,842.72 | 1,872 | BM7V485 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $31,008.56 | 2,321 | BD06CS0 |
| 0.04% | OMER | OMEROS CORP | -- | $30,617.12 | 3,137 | B4NB858 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $30,551.19 | 8,061 | BPBJFM7 |
| 0.04% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $29,472.30 | 3,435 | BYP80F1 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $29,465.15 | 9,295 | BBNBTD2 |
| 0.03% | RGNX | REGENXBIO INC | -- | $28,593.74 | 2,338 | BZ0G875 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $28,077.13 | 3,709 | BFYQFJ2 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $25,812.80 | 2,482 | B91XRN2 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $24,875.10 | 2,490 | BQ6C357 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $24,860.16 | 7,488 | B3MZ6K5 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $24,545.60 | 6,670 | BMCWKZ2 |
| 0.03% | LXRX | LEXICON PHARMACEUTICALS INC | -- | $23,789.26 | 16,753 | BWFZX59 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $23,446.17 | 2,153 | BKLXFX5 |
| 0.03% | ANNX | ANNEXON INC | -- | $22,820.60 | 5,060 | BMVV9R5 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $22,680.00 | 2,625 | BMFK3H6 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $22,386.20 | 2,588 | BLFBZ32 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $21,901.04 | 4,228 | BMC3HS7 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $20,751.90 | 4,069 | BFY7DC4 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $20,493.00 | 660 | B292NQ7 |
| 0.02% | ABSI | ABSCI CORP | -- | $20,403.28 | 6,893 | BN94K69 |
| 0.02% | HCM | HUTCHMED CHINA-ADR | -- | $20,334.60 | 1,430 | BYXV9H7 |
| 0.02% | LYEL | LYELL IMMUNOPHARMA INC | -- | $20,129.92 | 886 | BTNMG41 |
| 0.02% | EOLS | EVOLUS INC | -- | $20,098.68 | 2,982 | BDRJH21 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $19,607.94 | 3,301 | 2107437 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $17,626.90 | 3,590 | BQHN6C7 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $17,347.06 | 1,754 | BP81RK8 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $16,966.58 | 863 | BPBPCG8 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $16,126.56 | 7,466 | BN4JN37 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $15,752.00 | 2,864 | BP81R42 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $15,071.22 | 4,974 | BDFKQ07 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $14,935.06 | 1,994 | BSMLR16 |
| 0.02% | AMRN | AMARIN CORP PLC -ADR | -- | $14,864.00 | 929 | BN72KB0 |
| 0.02% | PYXS | PYXIS ONCOLOGY INC | -- | $14,723.85 | 2,859 | BLBR8D5 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $14,442.36 | 3,946 | BMXNGZ6 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $14,342.72 | 2,128 | BKDQKM6 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $14,164.92 | 4,599 | BZC0D70 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $13,809.15 | 10,229 | BFZNYB7 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $13,727.70 | 2,179 | BL5B6Z1 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $13,458.90 | 986 | B9L5200 |
| 0.02% | NGNE | NEUROGENE INC | -- | $13,449.52 | 658 | BS2F741 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $13,320.36 | 2,724 | B12W3P6 |
| 0.01% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $12,196.80 | 3,960 | BYTYP72 |
| 0.01% | FHTX | FOGHORN THERAPEUTICS INC | -- | $11,883.36 | 2,606 | BMF7DT9 |
| 0.01% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $11,465.04 | 9,246 | BFMLGR4 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $11,422.21 | 2,467 | BP7L561 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $10,900.84 | 3,658 | BLN9Z50 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $10,483.70 | 2,557 | BY7RB53 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $10,362.50 | 4,145 | BZ8FPH3 |
| 0.01% | OABI | OMNIAB INC | -- | $9,786.61 | 5,657 | BN13S71 |
| 0.01% | HUMA | HUMACYTE INC | -- | $9,345.28 | 7,301 | BMYTJP4 |
| 0.01% | RNAC | CARTESIAN THERAPEUTICS INC | -- | $8,908.57 | 1,199 | BQB9HM8 |
| 0.01% | PEPG | PEPGEN INC | -- | $8,754.48 | 1,512 | BMTX3D7 |
| 0.01% | MXCT | MAXCYTE INC | -- | $8,208.05 | 4,915 | BKMQF66 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $8,071.26 | 3,281 | BKX9NQ0 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $7,925.16 | 1,252 | BKC9SX3 |
| 0.01% | CDXS | CODEXIS INC | -- | $6,615.99 | 4,161 | B5LL2C2 |
| 0.01% | MRSN | MERSANA THERAPEUTICS INC | -- | $6,299.70 | 230 | BVPKH99 |
| 0.01% | ALEC | ALECTOR INC | -- | $5,972.48 | 4,666 | BJ4LDC4 |
| 0.01% | NKTX | NKARTA INC | -- | $5,860.46 | 3,274 | BK80YJ8 |
| 0.01% | FATE | FATE THERAPEUTICS INC | -- | $5,742.36 | 5,317 | BCZS820 |
| 0.01% | CLYM | CLIMB BIO INC | -- | $5,498.24 | 3,124 | BMW5LX6 |
| 0.01% | PLRX | PLIANT THERAPEUTICS INC | -- | $4,443.10 | 2,830 | BMDWW66 |
| -- | MGNX | MACROGENICS INC | -- | $4,137.88 | 2,914 | BFDV8K0 |
| -- | TVGN | TEVOGEN BIO HOLDINGS INC | -- | $3,844.83 | 9,068 | BPG5P75 |
| -- | ARTV | ARTIVA BIOTHERAPEUTICS INC | -- | $3,727.06 | 1,126 | BMF1LJ7 |
| -- | ACRV | ACRIVON THERAPEUTICS INC | -- | $3,422.00 | 1,450 | BP2TPK4 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $3,419.50 | 3,908 | BF12XC2 |
| -- | BMEA | BIOMEA FUSION INC | -- | $2,770.43 | 2,743 | BNKF6N0 |
| -- | TCRX | TSCAN THERAPEUTICS INC | -- | $2,395.29 | 2,419 | BNLYBJ7 |
| -- | APLT | APPLIED THERAPEUTICS INC | -- | $1,714.85 | 6,639 | BJL38Z1 |
| -- | OKUR | ONKURE THERAPEUTICS INC-A | -- | $1,628.00 | 592 | BT7KGT6 |
| -- | QTTB | Q32 BIO INC | -- | $1,146.48 | 562 | BS2FKQ4 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| 34.87% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 28,973,002 | -- | 5,096 | -- |
| 34.33% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 28,523,852 | -- | 5,017 | -- |
| 21.04% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 17,482,728 | -- | 3,075 | -- |
| 17.00% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,122,633 | -- | 2,484 | -- |
| 15.73% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 13,070,827 | -- | 2,299 | -- |
| 7.90% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 6,566,683 | -- | 1,155 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $25,856,025.93 | 25,856,026 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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