BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 11/30/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 16.90% | 51.72% | 95.62% | 66.67% | 42.59% | 11.36% | 1.61% | 2.01% | 16.86% | 04/07/2010 |
| BIB Market Price | 17.00% | 51.90% | 95.85% | 66.74% | 42.98% | 11.47% | 1.66% | 2.03% | 16.87% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/24/2025- NAV $83.73
- NAV Change $+0.99
- Market Price $83.86
- Market Price Change $+1.23
- Trading Volume (M) 6,082
- 30-Day Median Bid Ask Spread 0.25%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/24/2025- NAV $83.73
- NAV Change $+0.99
- Market Price $83.86
- Market Price Change $+1.23
- Trading Volume (M) 6,082
- 30-Day Median Bid Ask Spread 0.25%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 12/24/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.84% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,130,855.18 | 11,082 | 2931034 |
| 5.46% | GILD | GILEAD SCIENCES INC | -- | $4,796,823.90 | 38,170 | 2369174 |
| 5.28% | AMGN | AMGEN INC | -- | $4,644,047.76 | 13,906 | 2023607 |
| 4.07% | REGN | REGENERON PHARMACEUTICALS | -- | $3,575,285.02 | 4,562 | 2730190 |
| 2.71% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $2,384,100.60 | 25,788 | 2989044 |
| 2.66% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,338,026.15 | 5,835 | B00FWN1 |
| 1.90% | INSM | INSMED INC | -- | $1,671,296.40 | 9,420 | 2614487 |
| 1.30% | BIIB | BIOGEN INC | -- | $1,142,618.40 | 6,480 | 2455965 |
| 1.24% | ARGX | ARGENX SE - ADR | -- | $1,093,035.70 | 1,286 | BDVLM39 |
| 1.11% | UTHR | UNITED THERAPEUTICS CORP | -- | $978,845.28 | 1,902 | 2430412 |
| 1.04% | ILMN | ILLUMINA INC | -- | $913,274.68 | 6,749 | 2613990 |
| 0.99% | INCY | INCYTE CORP | -- | $870,915.24 | 8,671 | 2471950 |
| 0.84% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $740,686.75 | 18,871 | BMVP7Y0 |
| 0.81% | MEDP | MEDPACE HOLDINGS INC | -- | $711,393.84 | 1,244 | BDCBC61 |
| 0.79% | RVMD | REVOLUTION MEDICINES INC | -- | $693,281.41 | 8,539 | BL71K91 |
| 0.79% | ROIV | ROIVANT SCIENCES LTD | -- | $691,177.50 | 30,719 | BMW4NZ9 |
| 0.74% | BBIO | BRIDGEBIO PHARMA INC | -- | $651,423.36 | 8,512 | BK1KWG8 |
| 0.74% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $647,079.72 | 4,404 | 2623911 |
| 0.71% | VTRS | VIATRIS INC | -- | $622,428.48 | 50,852 | BMWS3X9 |
| 0.69% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $604,628.46 | 1,003 | BD59BS7 |
| 0.69% | SMMT | SUMMIT THERAPEUTICS INC | -- | $604,352.78 | 32,881 | BMTVQS7 |
| 0.67% | GH | GUARDANT HEALTH INC | -- | $584,999.32 | 5,714 | BFXC911 |
| 0.66% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $577,140.72 | 2,712 | BV9G6B8 |
| 0.66% | IONS | IONIS PHARMACEUTICALS INC | -- | $576,970.10 | 7,154 | BDJ0LS6 |
| 0.64% | SNY | SANOFI-ADR | -- | $565,231.68 | 11,688 | 2964557 |
| 0.64% | MRNA | MODERNA INC | -- | $564,970.25 | 17,251 | BGSXTS3 |
| 0.63% | EXEL | EXELIXIS INC | -- | $550,771.42 | 11,842 | 2576941 |
| 0.58% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $509,976.32 | 8,477 | 2437071 |
| 0.56% | TEM | TEMPUS AI INC | -- | $490,625.10 | 7,635 | BSLSJJ0 |
| 0.55% | RNA | AVIDITY BIOSCIENCES INC | -- | $480,357.90 | 6,655 | BMWHPY1 |
| 0.52% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $458,427.20 | 2,684 | B4Q5ZN4 |
| 0.49% | ONC | BEONE MEDICINES LTD-ADR | -- | $433,304.70 | 1,390 | BYYWPW6 |
| 0.48% | BNTX | BIONTECH SE-ADR | -- | $424,213.92 | 4,464 | BK6H543 |
| 0.48% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $420,589.89 | 5,999 | BYQBFJ8 |
| 0.43% | -- | ABIVAX SA ADR USD 0.01 | -- | $378,823.17 | 2,607 | -- |
| 0.42% | CYTK | CYTOKINETICS INC | -- | $366,660.34 | 5,713 | BBBSBJ5 |
| 0.40% | HALO | HALOZYME THERAPEUTICS INC | -- | $355,321.54 | 5,194 | 2975098 |
| 0.40% | -- | CARIS LIFE SCIENCES INC COMMON STOCK USD 0.001 | -- | $351,926.88 | 12,462 | -- |
| 0.39% | AXSM | AXSOME THERAPEUTICS INC | -- | $342,156.28 | 2,227 | BYZR4X4 |
| 0.38% | NUVL | NUVALENT INC-A | -- | $337,374.40 | 3,190 | BMVBZD3 |
| 0.38% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $330,971.96 | 2,948 | BF2YWG4 |
| 0.37% | KRYS | KRYSTAL BIOTECH INC | -- | $321,902.49 | 1,281 | BD6JX35 |
| 0.35% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $303,609.80 | 1,105 | BQ721R4 |
| 0.32% | PTCT | PTC THERAPEUTICS INC | -- | $277,900.02 | 3,546 | B17VCN9 |
| 0.31% | PCVX | VAXCYTE INC | -- | $275,702.90 | 5,786 | BKPVGH6 |
| 0.31% | COGT | COGENT BIOSCIENCES INC | -- | $269,250.21 | 6,777 | BLR6XK8 |
| 0.30% | KYMR | KYMERA THERAPEUTICS INC | -- | $264,187.14 | 3,178 | BMPRZV5 |
| 0.28% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $245,287.24 | 2,761 | BDCBCD8 |
| 0.27% | CRSP | CRISPR THERAPEUTICS AG | -- | $238,238.71 | 4,201 | BDHF4K6 |
| 0.24% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $208,272.51 | 7,473 | 2713317 |
| 0.24% | ALKS | ALKERMES PLC | -- | $208,081.92 | 7,296 | B3P6D26 |
| 0.24% | IMVT | IMMUNOVANT INC | -- | $208,051.20 | 7,740 | BJRFSB7 |
| 0.24% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $206,645.16 | 4,506 | BFZQ0L8 |
| 0.23% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $206,073.33 | 2,957 | BQS9486 |
| 0.23% | ADMA | ADMA BIOLOGICS INC | -- | $205,404.48 | 10,512 | B9NSBM2 |
| 0.23% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $204,143.61 | 4,191 | BDD19F8 |
| 0.23% | INDV | INDIVIOR PLC | -- | $199,422.40 | 5,515 | BP0BQQ5 |
| 0.22% | FOLD | AMICUS THERAPEUTICS INC | -- | $194,199.00 | 13,628 | B19FQ48 |
| 0.22% | APGE | APOGEE THERAPEUTICS INC | -- | $189,133.98 | 2,422 | BM9HHL5 |
| 0.21% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $183,302.50 | 2,270 | BJDX8Y8 |
| 0.20% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $178,635.60 | 13,880 | BFNF1D6 |
| 0.20% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $178,535.20 | 5,008 | BP8JSP4 |
| 0.19% | LGND | LIGAND PHARMACEUTICALS | -- | $171,314.66 | 869 | 2501578 |
| 0.19% | TERN | TERNS PHARMACEUTICALS INC | -- | $168,630.02 | 3,979 | BMDJ0C9 |
| 0.19% | ACLX | ARCELLX INC | -- | $168,564.00 | 2,554 | BPCJ1Q2 |
| 0.18% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $159,324.50 | 5,410 | BKX9VD3 |
| 0.18% | TVTX | TRAVERE THERAPEUTICS INC | -- | $159,186.56 | 3,952 | BLFGJD5 |
| 0.18% | GRAL | GRAIL INC | -- | $158,182.92 | 1,722 | BSLSSX7 |
| 0.18% | VERA | VERA THERAPEUTICS INC | -- | $157,212.08 | 2,824 | BL55460 |
| 0.18% | TARS | TARSUS PHARMACEUTICALS INC | -- | $154,706.25 | 1,875 | BMH5RL1 |
| 0.17% | XENE | XENON PHARMACEUTICALS INC | -- | $153,619.13 | 3,413 | BRJ3GY4 |
| 0.17% | VCYT | VERACYTE INC | -- | $149,566.69 | 3,497 | BFTWZY0 |
| 0.17% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $147,345.38 | 4,261 | BJ62Z18 |
| 0.16% | CGON | CG ONCOLOGY INC | -- | $142,858.26 | 3,559 | BRBCSP4 |
| 0.16% | APLS | APELLIS PHARMACEUTICALS INC | -- | $140,594.08 | 5,588 | BYTQ6X1 |
| 0.16% | IDYA | IDEAYA BIOSCIENCES INC | -- | $138,152.96 | 3,872 | BK0VHF6 |
| 0.15% | WVE | WAVE LIFE SCIENCES LTD | -- | $134,758.00 | 7,384 | BYZG9R0 |
| 0.15% | IRON | DISC MEDICINE INC | -- | $134,076.81 | 1,667 | BMGJZJ8 |
| 0.15% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $131,133.41 | 2,533 | B72ZBG4 |
| 0.15% | MLYS | MINERALYS THERAPEUTICS INC | -- | $130,855.28 | 3,496 | BP9N0G0 |
| 0.15% | DYN | DYNE THERAPEUTICS INC | -- | $128,367.80 | 6,308 | BN15WD1 |
| 0.15% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $127,608.04 | 4,676 | BKY5JZ8 |
| 0.14% | BEAM | BEAM THERAPEUTICS INC | -- | $126,123.48 | 4,482 | BK6L288 |
| 0.14% | OCUL | OCULAR THERAPEUTIX INC | -- | $119,550.26 | 9,406 | BNZB1X8 |
| 0.13% | SYRE | SPYRE THERAPEUTICS INC | -- | $113,262.35 | 3,427 | BQBBDY8 |
| 0.13% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $112,473.24 | 6,743 | BJ5FZ74 |
| 0.13% | DNLI | DENALI THERAPEUTICS INC | -- | $110,061.22 | 6,478 | BD2B4V0 |
| 0.12% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $109,422.48 | 4,261 | BLB0YQ9 |
| 0.12% | SRPT | SAREPTA THERAPEUTICS INC | -- | $103,051.44 | 4,617 | B8DPDT7 |
| 0.12% | ZBIO | ZENAS BIOPHARMA INC | -- | $102,356.07 | 2,371 | BQB42H3 |
| 0.11% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $99,928.40 | 22,711 | BM9FJ13 |
| 0.11% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $97,918.56 | 2,544 | BKSGZN7 |
| 0.11% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $95,361.30 | 3,474 | BMZ4LN0 |
| 0.11% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $94,769.33 | 5,823 | BFWLC09 |
| 0.11% | IBRX | IMMUNITYBIO INC | -- | $93,100.70 | 43,505 | BNSP0B8 |
| 0.10% | TWST | TWIST BIOSCIENCE CORP | -- | $90,632.42 | 2,699 | BGKG6G7 |
| 0.10% | MAZE | MAZE THERAPEUTICS INC | -- | $89,420.00 | 2,125 | BSRK699 |
| 0.10% | ZYME | ZYMEWORKS INC | -- | $88,772.30 | 3,305 | BPCQZY9 |
| 0.10% | GMAB | GENMAB A/S -SP ADR | -- | $87,065.04 | 2,582 | BBC9WC7 |
| 0.10% | SION | SIONNA THERAPEUTICS INC | -- | $86,773.28 | 1,971 | BQKXDX4 |
| 0.10% | NRIX | NURIX THERAPEUTICS INC | -- | $86,674.72 | 4,477 | BMVLGP2 |
| 0.10% | TXG | 10X GENOMICS INC-CLASS A | -- | $85,886.74 | 5,146 | BKS3RS7 |
| 0.10% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $85,462.62 | 3,719 | BMX9K07 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $84,767.55 | 1,995 | BRXB0C0 |
| 0.10% | VCEL | VERICEL CORP | -- | $83,909.04 | 2,234 | BSBMN89 |
| 0.09% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $82,922.40 | 3,839 | BN7Q7R7 |
| 0.09% | HROW | HARROW INC | -- | $82,061.76 | 1,636 | BHNDW86 |
| 0.09% | ANIP | ANI PHARMACEUTICALS INC | -- | $81,522.56 | 992 | BCDWBX6 |
| 0.09% | STOK | STOKE THERAPEUTICS INC | -- | $81,164.91 | 2,523 | BJQ05Z6 |
| 0.09% | MNKD | MANNKIND CORP | -- | $80,428.59 | 13,563 | BF081J4 |
| 0.09% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $79,776.06 | 5,187 | BRJZSK0 |
| 0.09% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $75,141.92 | 2,576 | BCBVTX1 |
| 0.08% | TRVI | TREVI THERAPEUTICS INC | -- | $73,462.08 | 5,664 | BJH9ZN0 |
| 0.08% | -- | PHARVARIS NV COMMON STOCK USD 0.12 | -- | $73,355.97 | 2,829 | -- |
| 0.08% | ALVO | ALVOTECH SA | -- | $73,139.54 | 13,826 | BPNTJ34 |
| 0.08% | KOD | KODIAK SCIENCES INC | -- | $72,820.44 | 2,343 | BFXC933 |
| 0.08% | UPB | UPSTREAM BIO INC | -- | $72,254.49 | 2,387 | BRCFFK6 |
| 0.08% | FTRE | FORTREA HOLDINGS INC | -- | $72,233.70 | 4,081 | BRXYZ57 |
| 0.08% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $71,602.30 | 9,299 | 2100362 |
| 0.08% | TSHA | TAYSHA GENE THERAPIES INC | -- | $71,505.09 | 12,099 | BNC1BX1 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $70,470.39 | 1,927 | BLCD809 |
| 0.08% | QURE | UNIQURE NV | -- | $69,297.69 | 2,751 | BJFSR88 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $69,213.68 | 1,396 | BX7RSN3 |
| 0.08% | ORKA | ORUKA THERAPEUTICS INC | -- | $68,672.56 | 2,138 | BKVF0J2 |
| 0.08% | ATAI | ATAI LIFE SCIENCES NV | -- | $67,215.98 | 16,042 | BN6M8F1 |
| 0.08% | EYPT | EYEPOINT INC | -- | $66,776.82 | 3,657 | BMGS7L1 |
| 0.08% | NVCR | NOVOCURE LTD | -- | $66,474.24 | 4,946 | BYSS4X4 |
| 0.08% | RLAY | RELAY THERAPEUTICS INC | -- | $66,215.75 | 7,655 | BN2R582 |
| 0.07% | PGEN | PRECIGEN INC | -- | $65,334.67 | 15,593 | BKM5C84 |
| 0.07% | INVA | INNOVIVA INC | -- | $65,300.31 | 3,303 | BDDXF67 |
| 0.07% | RAPP | RAPPORT THERAPEUTICS INC | -- | $65,169.51 | 2,107 | BR3T9B6 |
| 0.07% | ARDX | ARDELYX INC | -- | $64,284.68 | 10,732 | BN89V40 |
| 0.07% | MBX | MBX BIOSCIENCES INC | -- | $63,674.13 | 1,983 | BQXJKH2 |
| 0.07% | TYRA | TYRA BIOSCIENCES INC | -- | $61,376.28 | 2,357 | BMVNDH9 |
| 0.07% | ANAB | ANAPTYSBIO INC | -- | $61,162.23 | 1,223 | BDRW1L7 |
| 0.07% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $60,588.99 | 4,851 | BPCK358 |
| 0.07% | MNMD | MIND MEDICINE MINDMED INC | -- | $58,433.93 | 4,351 | BPQYY97 |
| 0.07% | SEPN | SEPTERNA INC | -- | $58,291.66 | 1,978 | BQNKXX2 |
| 0.07% | SVRA | SAVARA INC | -- | $57,516.80 | 8,987 | BYXGN81 |
| 0.06% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $55,487.72 | 3,142 | BJLKVS6 |
| 0.06% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $54,424.30 | 2,030 | BNFWZS4 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $53,295.45 | 11,765 | BMFJJ97 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $52,842.09 | 7,329 | BLR7H87 |
| 0.06% | TNGX | TANGO THERAPEUTICS INC | -- | $51,756.30 | 5,949 | BP2P6L0 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $51,676.01 | 1,289 | BKLCWZ3 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $51,591.12 | 642 | BNSP8K3 |
| 0.06% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $50,732.64 | 2,876 | BP7KZP7 |
| 0.06% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $50,322.58 | 17,534 | BF0DMK7 |
| 0.06% | SPRY | ARS PHARMACEUTICALS INC | -- | $50,121.68 | 4,366 | BMCR7V2 |
| 0.06% | NVAX | NOVAVAX INC | -- | $49,808.38 | 7,177 | BJDQXG4 |
| 0.06% | PCRX | PACIRA BIOSCIENCES INC | -- | $49,438.00 | 1,900 | B3X26D8 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $49,252.80 | 13,240 | BL53SR3 |
| 0.06% | URGN | UROGEN PHARMA LTD | -- | $49,135.68 | 2,068 | BZ7PJQ1 |
| 0.06% | NTLA | INTELLIA THERAPEUTICS INC | -- | $49,014.49 | 5,111 | BYZM6C2 |
| 0.06% | ALMS | ALUMIS INC | -- | $48,951.60 | 4,294 | BPLQG36 |
| 0.06% | XNCR | XENCOR INC | -- | $48,729.30 | 3,154 | BGCYWN8 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $48,653.64 | 5,388 | B8K7T65 |
| 0.05% | OMER | OMEROS CORP | -- | $48,107.52 | 3,132 | B4NB858 |
| 0.05% | -- | RAPT THERAPEUTICS INC | -- | $43,868.16 | 1,224 | BTJZB49 |
| 0.05% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $43,849.33 | 2,621 | BMFD115 |
| 0.05% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $43,286.40 | 4,509 | BLB0YH0 |
| 0.05% | ERAS | ERASCA INC | -- | $42,981.33 | 12,531 | BNLYBF3 |
| 0.05% | KURA | KURA ONCOLOGY INC | -- | $42,426.16 | 3,836 | BYZD465 |
| 0.05% | CRMD | CORMEDIX INC | -- | $42,421.20 | 3,480 | BJ0LT31 |
| 0.05% | MESO | MESOBLAST LTD- SPON ADR | -- | $42,020.40 | 2,166 | BQS7491 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $41,936.47 | 2,239 | BMNDK09 |
| 0.05% | BCAX | BICARA THERAPEUTICS INC | -- | $41,793.40 | 2,420 | BQB42F1 |
| 0.05% | ESPR | ESPERION THERAPEUTICS INC | -- | $41,708.05 | 10,559 | BBNBTD2 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $40,691.05 | 8,495 | BZ0QMB7 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $40,634.67 | 1,823 | BMGTLY5 |
| 0.04% | GERN | GERON CORP | -- | $39,474.40 | 28,196 | 2370381 |
| 0.04% | JANX | JANUX THERAPEUTICS INC | -- | $38,021.67 | 2,657 | BMFX8Y7 |
| 0.04% | VIR | VIR BIOTECHNOLOGY INC | -- | $37,545.95 | 6,145 | BK4PZ38 |
| 0.04% | ORIC | ORIC PHARMACEUTICALS INC | -- | $36,265.86 | 4,302 | BKVDFF7 |
| 0.04% | LYEL | LYELL IMMUNOPHARMA INC | -- | $36,168.20 | 937 | BTNMG41 |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $35,801.28 | 802 | BQD3J33 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $35,259.07 | 2,233 | BD06CS0 |
| 0.04% | GOSS | GOSSAMER BIO INC | -- | $35,167.12 | 10,223 | BJ0CK86 |
| 0.04% | -- | GH RESEARCH PLC COMMON STOCK USD 0.01 | -- | $35,030.90 | 2,740 | -- |
| 0.04% | REPL | REPLIMUNE GROUP INC | -- | $34,961.85 | 3,465 | BDDVW37 |
| 0.04% | ARVN | ARVINAS INC | -- | $34,526.29 | 2,837 | BDZ30Q0 |
| 0.04% | IVVD | INVIVYD INC | -- | $34,394.40 | 12,240 | BM8NHS1 |
| 0.04% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $34,079.22 | 903 | BL95N25 |
| 0.04% | LXEO | LEXEO THERAPEUTICS INC | -- | $34,045.44 | 3,224 | BQ6C357 |
| 0.04% | ANNX | ANNEXON INC | -- | $33,115.74 | 6,393 | BMVV9R5 |
| 0.04% | PSNL | PERSONALIS INC | -- | $32,950.38 | 3,918 | BJQ0608 |
| 0.04% | CTMX | CYTOMX THERAPEUTICS INC | -- | $32,929.60 | 7,484 | BYWVTY5 |
| 0.04% | RGNX | REGENXBIO INC | -- | $32,332.56 | 2,236 | BZ0G875 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $32,172.33 | 5,389 | BYVQJ96 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $32,124.82 | 1,729 | BD9GVY0 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $29,399.85 | 3,555 | BFYQFJ2 |
| 0.03% | VTYX | VENTYX BIOSCIENCES INC | -- | $28,935.36 | 3,152 | BMG99Y1 |
| 0.03% | KROS | KEROS THERAPEUTICS INC | -- | $28,750.56 | 1,346 | BM7V485 |
| 0.03% | FULC | FULCRUM THERAPEUTICS INC | -- | $28,703.90 | 2,390 | BJDX8Z9 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $28,488.89 | 4,162 | BMC3HS7 |
| 0.03% | PRME | PRIME MEDICINE INC | -- | $28,463.61 | 7,973 | BPBJFM7 |
| 0.03% | CGEM | CULLINAN THERAPEUTICS INC | -- | $26,768.34 | 2,609 | BM90J52 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $25,069.80 | 13,335 | B4N8MH9 |
| 0.03% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $24,676.52 | 3,299 | BYP80F1 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $24,505.84 | 2,516 | BMFK3H6 |
| 0.03% | LENZ | LENZ THERAPEUTICS INC | -- | $23,687.48 | 1,382 | BQV0J03 |
| 0.03% | ABSI | ABSCI CORP | -- | $23,645.52 | 6,642 | BN94K69 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $23,423.10 | 7,185 | B3MZ6K5 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $23,042.82 | 2,378 | B91XRN2 |
| 0.03% | BIOA | BIOAGE LABS INC | -- | $22,302.72 | 1,584 | BT9K6D8 |
| 0.02% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $21,487.68 | 2,487 | BLFBZ32 |
| 0.02% | IMAB | I-MAB-SPONSORED ADR | -- | $21,260.96 | 4,592 | BKRRKY7 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $21,165.00 | 1,275 | B9L5200 |
| 0.02% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $21,139.80 | 6,406 | BMCWKZ2 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $21,080.61 | 639 | B292NQ7 |
| 0.02% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $20,444.40 | 2,524 | BKLXFX5 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $20,301.90 | 3,441 | BQHN6C7 |
| 0.02% | ETON | ETON PHARMACEUTICALS INC | -- | $20,133.15 | 1,185 | BGL0JK3 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $19,832.01 | 3,163 | 2107437 |
| 0.02% | EOLS | EVOLUS INC | -- | $19,611.55 | 2,863 | BDRJH21 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $19,422.12 | 2,852 | BMVBZF5 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $18,343.82 | 4,609 | BFY7DC4 |
| 0.02% | KMDA | KAMADA LTD | -- | $18,065.32 | 2,548 | B2Q9833 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $18,035.10 | 2,610 | B12W3P6 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $18,028.60 | 827 | BPBPCG8 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $17,859.04 | 1,688 | BP81RK8 |
| 0.02% | PEPG | PEPGEN INC | -- | $17,553.86 | 3,037 | BMTX3D7 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $17,431.61 | 1,939 | BSMLR16 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $16,777.80 | 4,780 | BDFKQ07 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $16,493.40 | 2,805 | BP81R42 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $15,006.60 | 3,780 | BMXNGZ6 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $14,884.80 | 8,860 | BFMLGR4 |
| 0.02% | CADL | CANDEL THERAPEUTICS INC | -- | $14,744.00 | 2,425 | BP0TQC5 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $14,679.12 | 3,946 | BYTYP72 |
| 0.02% | ACRS | ACLARIS THERAPEUTICS INC | -- | $14,549.44 | 4,786 | BYV2W40 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $14,287.56 | 2,044 | BKDQKM6 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $13,896.40 | 9,926 | BFZNYB7 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $13,881.55 | 4,435 | BZC0D70 |
| 0.02% | NGNE | NEUROGENE INC | -- | $13,727.88 | 684 | BS2F741 |
| 0.02% | AARD | AARDVARK THERAPEUTICS INC | -- | $13,718.12 | 962 | BTXQTX3 |
| 0.02% | LFCR | LIFECORE BIOMEDICAL INC | -- | $13,653.75 | 1,655 | 2517058 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $13,489.20 | 2,498 | BMF7DT9 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $13,357.80 | 7,380 | BN4JN37 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $13,266.96 | 2,226 | B7F2TY6 |
| 0.01% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $12,933.60 | 1,020 | BPRBTY7 |
| 0.01% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $12,734.36 | 2,074 | BL5B6Z1 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $12,492.62 | 3,451 | BLN9Z50 |
| 0.01% | OABI | OMNIAB INC | -- | $12,461.68 | 6,358 | BN13S71 |
| 0.01% | -- | JYONG BIOTECH LTD COMMON STOCK USD 0.00001 | -- | $11,954.48 | 3,358 | -- |
| 0.01% | QSI | QUANTUM-SI INC | -- | $11,314.47 | 8,637 | BNR5QT9 |
| 0.01% | -- | VOR BIOPHARMA INC COMMON STOCK USD 0.0001 | -- | $10,810.32 | 744 | -- |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $10,799.02 | 2,494 | BPRB2N7 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $10,606.42 | 2,606 | BY7RB53 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $9,716.04 | 2,364 | BP7L561 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $9,529.52 | 4,312 | BZ8FPH3 |
| 0.01% | CABA | CABALETTA BIO INC | -- | $9,311.88 | 4,252 | BK5MWR1 |
| 0.01% | HUMA | HUMACYTE INC | -- | $8,933.76 | 8,272 | BMYTJP4 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $8,904.48 | 4,281 | BKX9NQ0 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $8,296.14 | 1,369 | BP2NYN2 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $8,157.50 | 1,255 | BKC9SX3 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $7,154.26 | 5,339 | BRK0149 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $7,100.16 | 4,128 | BNYJR68 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $6,720.39 | 2,517 | BKTV702 |
| 0.01% | CDXS | CODEXIS INC | -- | $6,703.20 | 3,990 | B5LL2C2 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $6,375.84 | 4,308 | BNNXX18 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $5,478.73 | 7,354 | BNNXX52 |
| -- | PYXS | PYXIS ONCOLOGY INC | -- | $3,052.50 | 2,750 | BLBR8D5 |
| -- | -- | SUTRO BIOPHARMA INC COMMON STOCK USD 0.001 | -- | $10.75 | 01 | -- |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 36.63% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 32,204,851 | -- | 5,511 | -- |
| 32.43% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 28,505,764 | -- | 4,878 | -- |
| 26.34% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 23,152,898 | -- | 3,962 | -- |
| 16.51% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,515,850 | -- | 2,484 | -- |
| 15.28% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 13,434,758 | -- | 2,299 | -- |
| 4.21% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,699,087 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $27,618,291.31 | 27,618,291 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
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