BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 12/31/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 1/09/2026- NAV $82.58
- NAV Change $+0.25
- Market Price $82.62
- Market Price Change $+0.27
- Trading Volume (M) 8,912
- 30-Day Median Bid Ask Spread 0.25%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 1/09/2026- NAV $82.58
- NAV Change $+0.25
- Market Price $82.62
- Market Price Change $+0.27
- Trading Volume (M) 8,912
- 30-Day Median Bid Ask Spread 0.25%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 1/09/2026
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.95% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,210,539.38 | 11,233 | 2931034 |
| 5.35% | GILD | GILEAD SCIENCES INC | -- | $4,685,601.20 | 38,692 | 2369174 |
| 5.25% | AMGN | AMGEN INC | -- | $4,596,705.60 | 14,096 | 2023607 |
| 4.21% | REGN | REGENERON PHARMACEUTICALS | -- | $3,683,247.20 | 4,624 | 2730190 |
| 2.83% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $2,474,245.65 | 26,141 | 2989044 |
| 2.69% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,355,885.35 | 5,915 | B00FWN1 |
| 1.92% | INSM | INSMED INC | -- | $1,680,337.53 | 9,549 | 2614487 |
| 1.41% | BIIB | BIOGEN INC | -- | $1,232,475.78 | 6,569 | 2455965 |
| 1.17% | ARGX | ARGENX SE - ADR | -- | $1,028,190.96 | 1,304 | BDVLM39 |
| 1.17% | RVMD | REVOLUTION MEDICINES INC | -- | $1,026,947.84 | 8,656 | BL71K91 |
| 1.10% | ILMN | ILLUMINA INC | -- | $965,059.87 | 6,841 | 2613990 |
| 1.07% | INCY | INCYTE CORP | -- | $939,387.30 | 8,790 | 2471950 |
| 1.06% | UTHR | UNITED THERAPEUTICS CORP | -- | $931,667.44 | 1,928 | 2430412 |
| 0.88% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $768,411.93 | 19,129 | BMVP7Y0 |
| 0.86% | MEDP | MEDPACE HOLDINGS INC | -- | $750,295.00 | 1,261 | BDCBC61 |
| 0.78% | ROIV | ROIVANT SCIENCES LTD | -- | $684,435.22 | 31,139 | BMW4NZ9 |
| 0.76% | BBIO | BRIDGEBIO PHARMA INC | -- | $666,513.00 | 8,628 | BK1KWG8 |
| 0.75% | VTRS | VIATRIS INC | -- | $657,752.48 | 51,548 | BMWS3X9 |
| 0.75% | SMMT | SUMMIT THERAPEUTICS INC | -- | $655,954.08 | 33,331 | BMTVQS7 |
| 0.73% | GH | GUARDANT HEALTH INC | -- | $638,104.64 | 5,792 | BFXC911 |
| 0.69% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $606,166.56 | 4,464 | 2623911 |
| 0.69% | MRNA | MODERNA INC | -- | $599,804.10 | 17,487 | BGSXTS3 |
| 0.67% | IONS | IONIS PHARMACEUTICALS INC | -- | $582,335.60 | 7,252 | BDJ0LS6 |
| 0.66% | SNY | SANOFI-ADR | -- | $580,907.44 | 11,848 | 2964557 |
| 0.64% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $558,019.51 | 2,749 | BV9G6B8 |
| 0.60% | EXEL | EXELIXIS INC | -- | $528,656.16 | 12,004 | 2576941 |
| 0.60% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $522,799.02 | 1,017 | BD59BS7 |
| 0.59% | TEM | TEMPUS AI INC | -- | $512,863.53 | 7,739 | BSLSJJ0 |
| 0.58% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $506,557.35 | 8,593 | 2437071 |
| 0.56% | RNA | AVIDITY BIOSCIENCES INC | -- | $488,208.02 | 6,746 | BMWHPY1 |
| 0.54% | ONC | BEONE MEDICINES LTD-ADR | -- | $476,087.01 | 1,409 | BYYWPW6 |
| 0.52% | BNTX | BIONTECH SE-ADR | -- | $451,821.25 | 4,525 | BK6H543 |
| 0.50% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $438,434.73 | 2,721 | B4Q5ZN4 |
| 0.45% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $392,589.36 | 6,081 | BYQBFJ8 |
| 0.44% | AXSM | AXSOME THERAPEUTICS INC | -- | $382,290.66 | 2,257 | BYZR4X4 |
| 0.44% | HALO | HALOZYME THERAPEUTICS INC | -- | $381,554.55 | 5,265 | 2975098 |
| 0.41% | CYTK | CYTOKINETICS INC | -- | $361,745.37 | 5,787 | BBBSBJ5 |
| 0.41% | CAI | CARIS LIFE SCIENCES INC | -- | $360,138.32 | 12,632 | BT18HP9 |
| 0.39% | NUVL | NUVALENT INC-A | -- | $339,731.70 | 3,234 | BMVBZD3 |
| 0.39% | KRYS | KRYSTAL BIOTECH INC | -- | $339,571.59 | 1,299 | BD6JX35 |
| 0.37% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $323,064.00 | 1,120 | BQ721R4 |
| 0.35% | ABVX | ABIVAX SA-ADR | -- | $302,359.20 | 2,643 | BLC89B2 |
| 0.34% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $301,847.76 | 2,988 | BF2YWG4 |
| 0.32% | PTCT | PTC THERAPEUTICS INC | -- | $278,642.82 | 3,594 | B17VCN9 |
| 0.31% | PCVX | VAXCYTE INC | -- | $270,083.25 | 5,865 | BKPVGH6 |
| 0.28% | COGT | COGENT BIOSCIENCES INC | -- | $242,854.50 | 6,870 | BLR6XK8 |
| 0.28% | KYMR | KYMERA THERAPEUTICS INC | -- | $240,834.17 | 3,221 | BMPRZV5 |
| 0.26% | CRSP | CRISPR THERAPEUTICS AG | -- | $229,304.56 | 4,259 | BDHF4K6 |
| 0.26% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $226,206.00 | 4,248 | BDD19F8 |
| 0.26% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $224,535.78 | 2,799 | BDCBCD8 |
| 0.25% | ALKS | ALKERMES PLC | -- | $219,365.36 | 7,396 | B3P6D26 |
| 0.23% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $205,624.17 | 2,997 | BQS9486 |
| 0.23% | IMVT | IMMUNOVANT INC | -- | $204,231.38 | 7,846 | BJRFSB7 |
| 0.23% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $202,858.50 | 7,575 | 2713317 |
| 0.23% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $199,197.57 | 2,301 | BJDX8Y8 |
| 0.23% | INDV | INDIVIOR PLC | -- | $198,109.60 | 5,590 | BP0BQQ5 |
| 0.23% | FOLD | AMICUS THERAPEUTICS INC | -- | $197,263.92 | 13,814 | B19FQ48 |
| 0.22% | CGON | CG ONCOLOGY INC | -- | $195,553.60 | 3,608 | BRBCSP4 |
| 0.22% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $192,678.24 | 4,568 | BFZQ0L8 |
| 0.22% | APGE | APOGEE THERAPEUTICS INC | -- | $191,465.45 | 2,455 | BM9HHL5 |
| 0.22% | ADMA | ADMA BIOLOGICS INC | -- | $191,275.20 | 10,656 | B9NSBM2 |
| 0.21% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $182,347.20 | 14,070 | BFNF1D6 |
| 0.21% | LGND | LIGAND PHARMACEUTICALS | -- | $182,058.65 | 881 | 2501578 |
| 0.20% | GRAL | GRAIL INC | -- | $174,774.60 | 1,746 | BSLSSX7 |
| 0.20% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $174,462.12 | 5,076 | BP8JSP4 |
| 0.20% | ACLX | ARCELLX INC | -- | $171,573.03 | 2,589 | BPCJ1Q2 |
| 0.18% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $154,758.48 | 5,484 | BKX9VD3 |
| 0.18% | APLS | APELLIS PHARMACEUTICALS INC | -- | $154,627.20 | 5,664 | BYTQ6X1 |
| 0.17% | VCYT | VERACYTE INC | -- | $149,031.80 | 3,545 | BFTWZY0 |
| 0.17% | IDYA | IDEAYA BIOSCIENCES INC | -- | $146,716.50 | 3,925 | BK0VHF6 |
| 0.17% | TARS | TARSUS PHARMACEUTICALS INC | -- | $146,129.87 | 1,901 | BMH5RL1 |
| 0.17% | XENE | XENON PHARMACEUTICALS INC | -- | $145,839.00 | 3,460 | BRJ3GY4 |
| 0.16% | TERN | TERNS PHARMACEUTICALS INC | -- | $143,090.84 | 4,033 | BMDJ0C9 |
| 0.16% | VERA | VERA THERAPEUTICS INC | -- | $139,456.73 | 2,863 | BL55460 |
| 0.16% | TVTX | TRAVERE THERAPEUTICS INC | -- | $138,527.48 | 4,006 | BLFGJD5 |
| 0.15% | IRON | DISC MEDICINE INC | -- | $132,056.60 | 1,690 | BMGJZJ8 |
| 0.15% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $131,250.48 | 2,568 | B72ZBG4 |
| 0.14% | BEAM | BEAM THERAPEUTICS INC | -- | $125,159.65 | 4,543 | BK6L288 |
| 0.14% | MLYS | MINERALYS THERAPEUTICS INC | -- | $118,263.28 | 3,544 | BP9N0G0 |
| 0.13% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $118,026.00 | 4,740 | BKY5JZ8 |
| 0.13% | DYN | DYNE THERAPEUTICS INC | -- | $113,621.38 | 6,394 | BN15WD1 |
| 0.13% | DNLI | DENALI THERAPEUTICS INC | -- | $112,164.36 | 6,567 | BD2B4V0 |
| 0.13% | SRPT | SAREPTA THERAPEUTICS INC | -- | $111,524.40 | 4,680 | B8DPDT7 |
| 0.12% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $107,719.60 | 6,835 | BJ5FZ74 |
| 0.12% | OCUL | OCULAR THERAPEUTIX INC | -- | $107,364.10 | 9,535 | BNZB1X8 |
| 0.12% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $107,282.52 | 23,022 | BM9FJ13 |
| 0.12% | TXG | 10X GENOMICS INC-CLASS A | -- | $106,719.36 | 5,216 | BKS3RS7 |
| 0.12% | SYRE | SPYRE THERAPEUTICS INC | -- | $106,339.14 | 3,474 | BQBBDY8 |
| 0.12% | WVE | WAVE LIFE SCIENCES LTD | -- | $103,592.40 | 7,485 | BYZG9R0 |
| 0.12% | IBRX | IMMUNITYBIO INC | -- | $102,753.00 | 44,100 | BNSP0B8 |
| 0.11% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $99,420.45 | 2,579 | BKSGZN7 |
| 0.11% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $98,897.76 | 3,522 | BMZ4LN0 |
| 0.11% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $97,220.69 | 4,319 | BJ62Z18 |
| 0.11% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $96,831.98 | 4,319 | BLB0YQ9 |
| 0.11% | TWST | TWIST BIOSCIENCE CORP | -- | $96,635.52 | 2,736 | BGKG6G7 |
| 0.10% | GMAB | GENMAB A/S -SP ADR | -- | $89,658.42 | 2,617 | BBC9WC7 |
| 0.10% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $89,430.45 | 5,903 | BFWLC09 |
| 0.10% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $88,972.00 | 3,770 | BMX9K07 |
| 0.10% | NRIX | NURIX THERAPEUTICS INC | -- | $87,583.40 | 4,538 | BMVLGP2 |
| 0.10% | VCEL | VERICEL CORP | -- | $87,338.40 | 2,265 | BSBMN89 |
| 0.10% | MAZE | MAZE THERAPEUTICS INC | -- | $86,849.28 | 2,154 | BSRK699 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $86,278.74 | 2,022 | BRXB0C0 |
| 0.10% | ERAS | ERASCA INC | -- | $85,865.52 | 12,702 | BNLYBF3 |
| 0.10% | ALMS | ALUMIS INC | -- | $85,144.68 | 4,353 | BPLQG36 |
| 0.10% | ARDX | ARDELYX INC | -- | $84,203.46 | 10,879 | BN89V40 |
| 0.10% | STOK | STOKE THERAPEUTICS INC | -- | $83,997.45 | 2,557 | BJQ05Z6 |
| 0.09% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $81,711.00 | 3,891 | BN7Q7R7 |
| 0.09% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $81,025.78 | 5,258 | BRJZSK0 |
| 0.09% | MNKD | MANNKIND CORP | -- | $80,425.80 | 13,748 | BF081J4 |
| 0.09% | SION | SIONNA THERAPEUTICS INC | -- | $78,421.50 | 1,998 | BQKXDX4 |
| 0.09% | ZYME | ZYMEWORKS INC | -- | $77,619.50 | 3,350 | BPCQZY9 |
| 0.09% | HROW | HARROW INC | -- | $77,561.24 | 1,658 | BHNDW86 |
| 0.09% | ANIP | ANI PHARMACEUTICALS INC | -- | $76,737.68 | 1,006 | BCDWBX6 |
| 0.08% | PHVS | PHARVARIS NV | -- | $74,252.52 | 2,868 | BMZ2X38 |
| 0.08% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $74,178.51 | 2,611 | BCBVTX1 |
| 0.08% | PGEN | PRECIGEN INC | -- | $72,554.13 | 15,807 | BKM5C84 |
| 0.08% | UPB | UPSTREAM BIO INC | -- | $71,995.00 | 2,420 | BRCFFK6 |
| 0.08% | NVCR | NOVOCURE LTD | -- | $71,950.90 | 5,014 | BYSS4X4 |
| 0.08% | FTRE | FORTREA HOLDINGS INC | -- | $71,942.43 | 4,137 | BRXYZ57 |
| 0.08% | TNGX | TANGO THERAPEUTICS INC | -- | $70,852.50 | 6,030 | BP2P6L0 |
| 0.08% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $70,776.20 | 2,915 | BP7KZP7 |
| 0.08% | QURE | UNIQURE NV | -- | $70,617.48 | 2,789 | BJFSR88 |
| 0.08% | TYRA | TYRA BIOSCIENCES INC | -- | $70,021.59 | 2,389 | BMVNDH9 |
| 0.08% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $69,752.40 | 9,426 | 2100362 |
| 0.08% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $69,082.00 | 2,657 | BMFD115 |
| 0.08% | KOD | KODIAK SCIENCES INC | -- | $65,835.00 | 2,375 | BFXC933 |
| 0.07% | INVA | INNOVIVA INC | -- | $65,553.84 | 3,348 | BDDXF67 |
| 0.07% | ALVO | ALVOTECH SA | -- | $65,029.60 | 14,015 | BPNTJ34 |
| 0.07% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $64,449.00 | 1,953 | BLCD809 |
| 0.07% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $64,439.10 | 1,415 | BX7RSN3 |
| 0.07% | TRVI | TREVI THERAPEUTICS INC | -- | $64,184.38 | 5,741 | BJH9ZN0 |
| 0.07% | MBX | MBX BIOSCIENCES INC | -- | $63,636.60 | 2,010 | BQXJKH2 |
| 0.07% | RLAY | RELAY THERAPEUTICS INC | -- | $62,002.40 | 7,760 | BN2R582 |
| 0.07% | RAPP | RAPPORT THERAPEUTICS INC | -- | $61,858.56 | 2,136 | BR3T9B6 |
| 0.07% | TSHA | TAYSHA GENE THERAPIES INC | -- | $61,074.72 | 12,264 | BNC1BX1 |
| 0.07% | MNMD | MIND MEDICINE MINDMED INC | -- | $61,034.40 | 4,410 | BPQYY97 |
| 0.07% | ATAI | ATAIBECKLEY INC | -- | $60,978.75 | 16,261 | BWJDYK1 |
| 0.07% | ORKA | ORUKA THERAPEUTICS INC | -- | $60,372.62 | 2,167 | BKVF0J2 |
| 0.07% | EYPT | EYEPOINT INC | -- | $60,164.61 | 3,707 | BMGS7L1 |
| 0.07% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $60,036.57 | 4,917 | BPCK358 |
| 0.07% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $58,911.97 | 7,429 | BLR7H87 |
| 0.07% | ABCL | ABCELLERA BIOLOGICS INC | -- | $58,649.77 | 13,421 | BL53SR3 |
| 0.07% | SPRY | ARS PHARMACEUTICALS INC | -- | $57,803.56 | 4,426 | BMCR7V2 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $57,088.92 | 2,058 | BNFWZS4 |
| 0.06% | ANAB | ANAPTYSBIO INC | -- | $55,390.80 | 1,240 | BDRW1L7 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $54,382.56 | 11,926 | BMFJJ97 |
| 0.06% | NTLA | INTELLIA THERAPEUTICS INC | -- | $53,778.78 | 5,181 | BYZM6C2 |
| 0.06% | SVRA | SAVARA INC | -- | $52,929.10 | 9,110 | BYXGN81 |
| 0.06% | NVAX | NOVAVAX INC | -- | $52,889.25 | 7,275 | BJDQXG4 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $51,417.38 | 1,307 | BKLCWZ3 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $51,178.94 | 5,462 | B8K7T65 |
| 0.06% | SEPN | SEPTERNA INC | -- | $50,726.50 | 2,005 | BQNKXX2 |
| 0.05% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $47,822.78 | 3,185 | BJLKVS6 |
| 0.05% | INBX | INHIBRX BIOSCIENCES INC | -- | $47,431.86 | 651 | BNSP8K3 |
| 0.05% | MESO | MESOBLAST LTD- SPON ADR | -- | $46,028.16 | 2,196 | BQS7491 |
| 0.05% | PCRX | PACIRA BIOSCIENCES INC | -- | $45,318.78 | 1,926 | B3X26D8 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $44,540.00 | 2,096 | BZ7PJQ1 |
| 0.05% | XNCR | XENCOR INC | -- | $44,406.33 | 3,197 | BGCYWN8 |
| 0.05% | VTYX | VENTYX BIOSCIENCES INC | -- | $44,122.95 | 3,195 | BMG99Y1 |
| 0.05% | BCAX | BICARA THERAPEUTICS INC | -- | $44,031.35 | 2,453 | BQB42F1 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $43,546.30 | 17,774 | BF0DMK7 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $43,220.80 | 2,270 | BMNDK09 |
| 0.05% | RAPT | RAPT THERAPEUTICS INC | -- | $41,722.42 | 1,241 | BTJZB49 |
| 0.05% | GHRS | GH RESEARCH PLC | -- | $41,682.77 | 2,777 | BP6C0S2 |
| 0.05% | ESPR | ESPERION THERAPEUTICS INC | -- | $41,527.64 | 10,703 | BBNBTD2 |
| 0.05% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $40,864.74 | 4,571 | BLB0YH0 |
| 0.05% | ORIC | ORIC PHARMACEUTICALS INC | -- | $39,903.15 | 4,361 | BKVDFF7 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $39,782.82 | 8,611 | BZ0QMB7 |
| 0.05% | OMER | OMEROS CORP | -- | $39,655.75 | 3,175 | B4NB858 |
| 0.04% | ZBIO | ZENAS BIOPHARMA INC | -- | $38,640.24 | 2,403 | BQB42H3 |
| 0.04% | GERN | GERON CORP | -- | $38,299.88 | 28,582 | 2370381 |
| 0.04% | JANX | JANUX THERAPEUTICS INC | -- | $38,132.88 | 2,693 | BMFX8Y7 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $38,035.20 | 2,264 | BD06CS0 |
| 0.04% | AVBP | ARRIVENT BIOPHARMA INC | -- | $37,920.96 | 1,848 | BMGTLY5 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $36,595.49 | 3,889 | BYZD465 |
| 0.04% | VIR | VIR BIOTECHNOLOGY INC | -- | $36,439.65 | 6,229 | BK4PZ38 |
| 0.04% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $36,087.60 | 915 | BL95N25 |
| 0.04% | ARVN | ARVINAS INC | -- | $34,713.32 | 2,876 | BDZ30Q0 |
| 0.04% | LXEO | LEXEO THERAPEUTICS INC | -- | $34,444.72 | 3,268 | BQ6C357 |
| 0.04% | ANNX | ANNEXON INC | -- | $34,020.00 | 6,480 | BMVV9R5 |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $33,202.92 | 813 | BQD3J33 |
| 0.04% | RGNX | REGENXBIO INC | -- | $33,075.53 | 2,267 | BZ0G875 |
| 0.04% | CTMX | CYTOMX THERAPEUTICS INC | -- | $32,999.10 | 7,586 | BYWVTY5 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $32,518.15 | 1,753 | BD9GVY0 |
| 0.04% | PSNL | PERSONALIS INC | -- | $32,173.20 | 3,972 | BJQ0608 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $31,843.08 | 8,082 | BPBJFM7 |
| 0.04% | IVVD | INVIVYD INC | -- | $31,265.64 | 12,407 | BM8NHS1 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $30,461.18 | 4,219 | BMC3HS7 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $29,568.98 | 7,283 | B3MZ6K5 |
| 0.03% | CGEM | CULLINAN THERAPEUTICS INC | -- | $28,830.50 | 2,645 | BM90J52 |
| 0.03% | REPL | REPLIMUNE GROUP INC | -- | $28,201.36 | 3,512 | BDDVW37 |
| 0.03% | CRMD | CORMEDIX INC | -- | $26,918.64 | 3,528 | BJ0LT31 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $26,705.64 | 3,604 | BFYQFJ2 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $26,222.98 | 13,517 | B4N8MH9 |
| 0.03% | KROS | KEROS THERAPEUTICS INC | -- | $26,188.80 | 1,364 | BM7V485 |
| 0.03% | GOSS | GOSSAMER BIO INC | -- | $25,907.50 | 10,363 | BJ0CK86 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $25,521.42 | 6,494 | BMCWKZ2 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $23,944.50 | 2,550 | BMFK3H6 |
| 0.03% | FULC | FULCRUM THERAPEUTICS INC | -- | $23,866.55 | 2,423 | BJDX8Z9 |
| 0.03% | LYEL | LYELL IMMUNOPHARMA INC | -- | $23,322.50 | 950 | BTNMG41 |
| 0.03% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $22,705.76 | 3,344 | BYP80F1 |
| 0.03% | BIOA | BIOAGE LABS INC | -- | $22,532.18 | 1,606 | BT9K6D8 |
| 0.03% | ABSI | ABSCI CORP | -- | $22,454.56 | 6,733 | BN94K69 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $22,157.09 | 2,411 | B91XRN2 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $21,455.28 | 648 | B292NQ7 |
| 0.02% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $21,403.29 | 2,521 | BLFBZ32 |
| 0.02% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $21,360.33 | 5,463 | BYVQJ96 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $21,191.66 | 3,206 | 2107437 |
| 0.02% | LENZ | LENZ THERAPEUTICS INC | -- | $20,832.87 | 1,401 | BQV0J03 |
| 0.02% | KMDA | KAMADA LTD | -- | $20,767.32 | 2,583 | B2Q9833 |
| 0.02% | PEPG | PEPGEN INC | -- | $19,921.13 | 3,079 | BMTX3D7 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $19,395.18 | 2,646 | B12W3P6 |
| 0.02% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $19,192.50 | 2,559 | BKLXFX5 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $18,781.44 | 4,672 | BFY7DC4 |
| 0.02% | ETON | ETON PHARMACEUTICALS INC | -- | $18,567.46 | 1,201 | BGL0JK3 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $18,451.52 | 3,488 | BQHN6C7 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $18,071.85 | 4,845 | BDFKQ07 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $17,229.28 | 838 | BPBPCG8 |
| 0.02% | NBP | NOVABRIDGE BIOSCIENCES | -- | $17,223.50 | 4,655 | BKRRKY7 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $17,206.02 | 10,062 | BFZNYB7 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $17,144.22 | 1,711 | BP81RK8 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $17,120.00 | 4,000 | BYTYP72 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $16,938.12 | 1,292 | B9L5200 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $16,607.82 | 7,481 | BN4JN37 |
| 0.02% | EOLS | EVOLUS INC | -- | $16,396.30 | 2,902 | BDRJH21 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $16,348.80 | 1,965 | BSMLR16 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $16,255.61 | 8,981 | BFMLGR4 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $15,331.36 | 4,496 | BZC0D70 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $14,470.87 | 2,843 | BP81R42 |
| 0.02% | CADL | CANDEL THERAPEUTICS INC | -- | $14,035.18 | 2,458 | BP0TQC5 |
| 0.02% | AARD | AARDVARK THERAPEUTICS INC | -- | $13,913.25 | 975 | BTXQTX3 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $13,784.16 | 2,256 | B7F2TY6 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $13,758.08 | 2,072 | BKDQKM6 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $13,457.61 | 2,891 | BMVBZF5 |
| 0.01% | FHTX | FOGHORN THERAPEUTICS INC | -- | $13,065.12 | 2,532 | BMF7DT9 |
| 0.01% | MENS | JYONG BIOTECH LTD | -- | $12,969.24 | 3,404 | BPTK6Z2 |
| 0.01% | ACRS | ACLARIS THERAPEUTICS INC | -- | $12,806.64 | 4,851 | BYV2W40 |
| 0.01% | LRMR | LARIMAR THERAPEUTICS INC | -- | $12,760.56 | 3,832 | BMXNGZ6 |
| 0.01% | LFCR | LIFECORE BIOMEDICAL INC | -- | $12,685.68 | 1,678 | 2517058 |
| 0.01% | NGNE | NEUROGENE INC | -- | $12,418.56 | 693 | BS2F741 |
| 0.01% | OABI | OMNIAB INC | -- | $12,309.95 | 6,445 | BN13S71 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $12,134.40 | 2,528 | BPRB2N7 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $12,068.10 | 3,498 | BLN9Z50 |
| 0.01% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $11,603.04 | 2,102 | BL5B6Z1 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $10,681.10 | 8,755 | BNR5QT9 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $10,620.84 | 2,642 | BY7RB53 |
| 0.01% | VOR | VOR BIOPHARMA INC | -- | $10,194.08 | 754 | BRJJYT3 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $10,039.24 | 2,396 | BP7L561 |
| 0.01% | HUMA | HUMACYTE INC | -- | $9,810.45 | 8,385 | BMYTJP4 |
| 0.01% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $9,626.54 | 1,034 | BPRBTY7 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $9,287.60 | 4,340 | BKX9NQ0 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $9,146.28 | 5,412 | BRK0149 |
| 0.01% | CABA | CABALETTA BIO INC | -- | $9,051.00 | 4,310 | BK5MWR1 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $9,047.97 | 4,371 | BZ8FPH3 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $8,624.16 | 1,272 | BKC9SX3 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $8,619.48 | 1,388 | BP2NYN2 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $7,168.31 | 2,551 | BKTV702 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $6,945.44 | 4,184 | BNYJR68 |
| 0.01% | CDXS | CODEXIS INC | -- | $6,633.80 | 4,045 | B5LL2C2 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $6,113.80 | 4,367 | BNNXX18 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $5,700.09 | 7,455 | BNNXX52 |
| 0.01% | PYXS | PYXIS ONCOLOGY INC | -- | $4,906.88 | 2,788 | BLBR8D5 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $12.23 | 01 | BTFHQP5 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| 38.51% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 33,712,065 | -- | 5,795 | -- |
| 32.42% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 28,377,472 | -- | 4,878 | -- |
| 23.43% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 20,506,476 | -- | 3,525 | -- |
| 16.51% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,450,521 | -- | 2,484 | -- |
| 15.28% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 13,374,295 | -- | 2,299 | -- |
| 4.21% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,682,440 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $26,689,554.85 | 26,689,555 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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