BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 12/31/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 1/30/2026- NAV $83.17
- NAV Change $-1.73
- Market Price $83.12
- Market Price Change $-1.77
- Trading Volume (M) 10,422
- 30-Day Median Bid Ask Spread 0.28%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 1/30/2026- NAV $83.17
- NAV Change $-1.73
- Market Price $83.12
- Market Price Change $-1.77
- Trading Volume (M) 10,422
- 30-Day Median Bid Ask Spread 0.28%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 12/31/2025
Holdings
as of 1/30/2026
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 6.58% | GILD | GILEAD SCIENCES INC | -- | $5,743,722.85 | 40,463 | 2369174 |
| 6.32% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,518,035.70 | 11,743 | 2931034 |
| 5.77% | AMGN | AMGEN INC | -- | $5,038,969.32 | 14,739 | 2023607 |
| 4.11% | REGN | REGENERON PHARMACEUTICALS | -- | $3,585,652.20 | 4,836 | 2730190 |
| 2.39% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,091,239.16 | 6,186 | B00FWN1 |
| 1.79% | INSM | INSMED INC | -- | $1,566,503.82 | 9,986 | 2614487 |
| 1.42% | BIIB | BIOGEN INC | -- | $1,235,664.41 | 6,869 | 2455965 |
| 1.31% | ARGX | ARGENX SE - ADR | -- | $1,145,601.50 | 1,363 | BDVLM39 |
| 1.19% | ILMN | ILLUMINA INC | -- | $1,035,970.74 | 7,154 | 2613990 |
| 1.08% | UTHR | UNITED THERAPEUTICS CORP | -- | $946,491.84 | 2,016 | 2430412 |
| 1.05% | INCY | INCYTE CORP | -- | $919,843.44 | 9,192 | 2471950 |
| 1.01% | RVMD | REVOLUTION MEDICINES INC | -- | $877,591.40 | 9,052 | BL71K91 |
| 0.95% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $833,808.40 | 20,005 | BMVP7Y0 |
| 0.92% | MRNA | MODERNA INC | -- | $806,128.44 | 18,292 | BGSXTS3 |
| 0.88% | MEDP | MEDPACE HOLDINGS INC | -- | $768,291.12 | 1,319 | BDCBC61 |
| 0.81% | VTRS | VIATRIS INC | -- | $705,917.52 | 53,928 | BMWS3X9 |
| 0.81% | ROIV | ROIVANT SCIENCES LTD | -- | $704,033.68 | 32,564 | BMW4NZ9 |
| 0.80% | BBIO | BRIDGEBIO PHARMA INC | -- | $697,129.94 | 9,022 | BK1KWG8 |
| 0.79% | GH | GUARDANT HEALTH INC | -- | $690,854.32 | 6,058 | BFXC911 |
| 0.74% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $650,037.50 | 2,875 | BV9G6B8 |
| 0.73% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $635,128.08 | 4,668 | 2623911 |
| 0.72% | IONS | IONIS PHARMACEUTICALS INC | -- | $626,969.28 | 7,584 | BDJ0LS6 |
| 0.67% | SNY | SANOFI-ADR | -- | $582,825.60 | 12,390 | 2964557 |
| 0.62% | BNTX | BIONTECH SE-ADR | -- | $538,492.50 | 4,734 | BK6H543 |
| 0.60% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $520,136.53 | 1,063 | BD59BS7 |
| 0.59% | EXEL | EXELIXIS INC | -- | $519,233.44 | 12,554 | 2576941 |
| 0.59% | RNA | AVIDITY BIOSCIENCES INC | -- | $511,981.35 | 7,055 | BMWHPY1 |
| 0.58% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $508,577.30 | 8,995 | 2437071 |
| 0.58% | SMMT | SUMMIT THERAPEUTICS INC | -- | $504,714.88 | 34,856 | BMTVQS7 |
| 0.57% | ONC | BEONE MEDICINES LTD-ADR | -- | $501,720.12 | 1,474 | BYYWPW6 |
| 0.55% | TEM | TEMPUS AI INC | -- | $484,183.08 | 8,094 | BSLSJJ0 |
| 0.54% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $467,974.05 | 2,845 | B4Q5ZN4 |
| 0.50% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $440,869.47 | 6,359 | BYQBFJ8 |
| 0.50% | AXSM | AXSOME THERAPEUTICS INC | -- | $434,830.00 | 2,360 | BYZR4X4 |
| 0.45% | HALO | HALOZYME THERAPEUTICS INC | -- | $394,835.26 | 5,506 | 2975098 |
| 0.43% | KRYS | KRYSTAL BIOTECH INC | -- | $379,207.92 | 1,358 | BD6JX35 |
| 0.42% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $367,694.00 | 1,171 | BQ721R4 |
| 0.41% | CYTK | CYTOKINETICS INC | -- | $361,762.75 | 5,725 | BBBSBJ5 |
| 0.40% | NUVL | NUVALENT INC-A | -- | $347,973.98 | 3,382 | BMVBZD3 |
| 0.38% | PCVX | VAXCYTE INC | -- | $328,330.53 | 6,129 | BKPVGH6 |
| 0.37% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $320,375.00 | 3,125 | BF2YWG4 |
| 0.35% | ABVX | ABIVAX SA-ADR | -- | $307,218.60 | 2,764 | BLC89B2 |
| 0.35% | CAI | CARIS LIFE SCIENCES INC | -- | $305,966.76 | 13,211 | BT18HP9 |
| 0.33% | IBRX | IMMUNITYBIO INC | -- | $288,237.50 | 46,118 | BNSP0B8 |
| 0.33% | PTCT | PTC THERAPEUTICS INC | -- | $283,917.27 | 3,759 | B17VCN9 |
| 0.32% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $276,760.05 | 3,129 | BQS9486 |
| 0.30% | ALKS | ALKERMES PLC | -- | $262,003.59 | 7,731 | B3P6D26 |
| 0.30% | COGT | COGENT BIOSCIENCES INC | -- | $258,085.17 | 7,187 | BLR6XK8 |
| 0.28% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $248,347.32 | 2,406 | BJDX8Y8 |
| 0.28% | KYMR | KYMERA THERAPEUTICS INC | -- | $244,892.61 | 3,369 | BMPRZV5 |
| 0.27% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $239,428.60 | 2,927 | BDCBCD8 |
| 0.26% | CRSP | CRISPR THERAPEUTICS AG | -- | $222,921.52 | 4,462 | BDHF4K6 |
| 0.25% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $221,883.42 | 4,443 | BDD19F8 |
| 0.24% | IMVT | IMMUNOVANT INC | -- | $213,382.00 | 8,207 | BJRFSB7 |
| 0.24% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $211,767.84 | 4,776 | BFZQ0L8 |
| 0.24% | -- | INDIVIOR PHARMACEUTICALS INC COMMON STOCK USD 0.001 | -- | $206,760.72 | 5,844 | -- |
| 0.24% | FOLD | AMICUS THERAPEUTICS INC | -- | $206,433.34 | 14,446 | B19FQ48 |
| 0.23% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $201,355.92 | 14,719 | BFNF1D6 |
| 0.23% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $199,054.73 | 7,921 | 2713317 |
| 0.23% | CGON | CG ONCOLOGY INC | -- | $196,592.85 | 3,777 | BRBCSP4 |
| 0.22% | ADMA | ADMA BIOLOGICS INC | -- | $192,791.20 | 11,144 | B9NSBM2 |
| 0.21% | ACLX | ARCELLX INC | -- | $184,915.17 | 2,707 | BPCJ1Q2 |
| 0.20% | GRAL | GRAIL INC | -- | $178,521.50 | 1,825 | BSLSSX7 |
| 0.20% | LGND | LIGAND PHARMACEUTICALS | -- | $177,116.20 | 922 | 2501578 |
| 0.19% | APGE | APOGEE THERAPEUTICS INC | -- | $168,164.17 | 2,567 | BM9HHL5 |
| 0.19% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $165,216.08 | 5,309 | BP8JSP4 |
| 0.17% | DNLI | DENALI THERAPEUTICS INC | -- | $149,288.58 | 6,867 | BD2B4V0 |
| 0.17% | XENE | XENON PHARMACEUTICALS INC | -- | $148,374.18 | 3,618 | BRJ3GY4 |
| 0.17% | TERN | TERNS PHARMACEUTICALS INC | -- | $145,942.80 | 4,218 | BMDJ0C9 |
| 0.17% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $145,496.95 | 5,735 | BKX9VD3 |
| 0.16% | VCYT | VERACYTE INC | -- | $140,934.08 | 3,701 | BFTWZY0 |
| 0.16% | ERAS | ERASCA INC | -- | $139,614.84 | 13,284 | BNLYBF3 |
| 0.16% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $139,539.55 | 4,957 | BKY5JZ8 |
| 0.16% | IRON | DISC MEDICINE INC | -- | $136,701.76 | 1,768 | BMGJZJ8 |
| 0.15% | APLS | APELLIS PHARMACEUTICALS INC | -- | $133,696.18 | 5,921 | BYTQ6X1 |
| 0.15% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $132,238.00 | 7,148 | BJ5FZ74 |
| 0.15% | IDYA | IDEAYA BIOSCIENCES INC | -- | $132,139.95 | 4,105 | BK0VHF6 |
| 0.15% | BEAM | BEAM THERAPEUTICS INC | -- | $131,222.62 | 4,751 | BK6L288 |
| 0.15% | TVTX | TRAVERE THERAPEUTICS INC | -- | $130,236.01 | 4,189 | BLFGJD5 |
| 0.15% | VERA | VERA THERAPEUTICS INC | -- | $129,390.66 | 2,991 | BL55460 |
| 0.15% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $129,309.60 | 2,685 | B72ZBG4 |
| 0.15% | TARS | TARSUS PHARMACEUTICALS INC | -- | $128,305.52 | 1,988 | BMH5RL1 |
| 0.14% | DYN | DYNE THERAPEUTICS INC | -- | $119,630.43 | 6,687 | BN15WD1 |
| 0.13% | TWST | TWIST BIOSCIENCE CORP | -- | $117,583.41 | 2,863 | BGKG6G7 |
| 0.13% | SYRE | SPYRE THERAPEUTICS INC | -- | $116,183.34 | 3,633 | BQBBDY8 |
| 0.13% | MLYS | MINERALYS THERAPEUTICS INC | -- | $114,447.45 | 3,705 | BP9N0G0 |
| 0.13% | ALMS | ALUMIS INC | -- | $111,569.52 | 4,552 | BPLQG36 |
| 0.13% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $110,982.69 | 4,517 | BLB0YQ9 |
| 0.13% | TXG | 10X GENOMICS INC-CLASS A | -- | $110,170.80 | 5,454 | BKS3RS7 |
| 0.12% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $108,724.19 | 4,517 | BJ62Z18 |
| 0.12% | WVE | WAVE LIFE SCIENCES LTD | -- | $101,333.14 | 7,831 | BYZG9R0 |
| 0.12% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $100,874.25 | 24,075 | BM9FJ13 |
| 0.11% | SRPT | SAREPTA THERAPEUTICS INC | -- | $99,788.04 | 4,906 | B8DPDT7 |
| 0.11% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $98,494.44 | 2,697 | BKSGZN7 |
| 0.11% | MAZE | MAZE THERAPEUTICS INC | -- | $98,185.74 | 2,253 | BSRK699 |
| 0.11% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $94,726.76 | 3,683 | BMZ4LN0 |
| 0.11% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $92,890.80 | 2,115 | BRXB0C0 |
| 0.10% | OCUL | OCULAR THERAPEUTIX INC | -- | $91,171.50 | 9,975 | BNZB1X8 |
| 0.10% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $89,693.69 | 6,173 | BFWLC09 |
| 0.10% | GMAB | GENMAB A/S -SP ADR | -- | $89,308.31 | 2,737 | BBC9WC7 |
| 0.10% | SION | SIONNA THERAPEUTICS INC | -- | $88,323.40 | 2,090 | BQKXDX4 |
| 0.10% | ARDX | ARDELYX INC | -- | $87,489.13 | 11,377 | BN89V40 |
| 0.10% | ANIP | ANI PHARMACEUTICALS INC | -- | $86,106.20 | 1,052 | BCDWBX6 |
| 0.10% | VCEL | VERICEL CORP | -- | $85,200.64 | 2,368 | BSBMN89 |
| 0.10% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $85,136.53 | 5,498 | BRJZSK0 |
| 0.10% | MNKD | MANNKIND CORP | -- | $83,104.84 | 14,378 | BF081J4 |
| 0.09% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $82,661.70 | 4,070 | BN7Q7R7 |
| 0.09% | STOK | STOKE THERAPEUTICS INC | -- | $81,159.50 | 2,675 | BJQ05Z6 |
| 0.09% | PHVS | PHARVARIS NV | -- | $81,122.95 | 2,999 | BMZ2X38 |
| 0.09% | ZYME | ZYMEWORKS INC | -- | $78,945.12 | 3,504 | BPCQZY9 |
| 0.09% | ALVO | ALVOTECH SA | -- | $78,702.72 | 14,656 | BPNTJ34 |
| 0.09% | UPB | UPSTREAM BIO INC | -- | $78,632.40 | 2,530 | BRCFFK6 |
| 0.09% | NRIX | NURIX THERAPEUTICS INC | -- | $78,403.92 | 4,746 | BMVLGP2 |
| 0.09% | -- | DEFINIUM THERAPEUTICS INC COMMON STOCK USD 0 | -- | $77,850.56 | 4,612 | -- |
| 0.09% | ORKA | ORUKA THERAPEUTICS INC | -- | $77,599.41 | 2,267 | BKVF0J2 |
| 0.09% | MBX | MBX BIOSCIENCES INC | -- | $77,458.70 | 2,102 | BQXJKH2 |
| 0.09% | TYRA | TYRA BIOSCIENCES INC | -- | $77,019.18 | 2,499 | BMVNDH9 |
| 0.09% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $74,911.20 | 2,730 | BCBVTX1 |
| 0.09% | RAPT | RAPT THERAPEUTICS INC | -- | $74,810.96 | 1,297 | BTJZB49 |
| 0.09% | PGEN | PRECIGEN INC | -- | $74,385.83 | 16,567 | BKM5C84 |
| 0.08% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $73,504.55 | 2,779 | BMFD115 |
| 0.08% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $73,479.18 | 5,142 | BPCK358 |
| 0.08% | TNGX | TANGO THERAPEUTICS INC | -- | $73,212.66 | 6,306 | BP2P6L0 |
| 0.08% | FTRE | FORTREA HOLDINGS INC | -- | $72,720.06 | 4,326 | BRXYZ57 |
| 0.08% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $72,387.90 | 3,497 | BYP80F1 |
| 0.08% | NTLA | INTELLIA THERAPEUTICS INC | -- | $71,312.45 | 5,423 | BYZM6C2 |
| 0.08% | HROW | HARROW INC | -- | $70,989.96 | 1,734 | BHNDW86 |
| 0.08% | INVA | INNOVIVA INC | -- | $70,020.00 | 3,501 | BDDXF67 |
| 0.08% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $68,985.00 | 3,942 | BMX9K07 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $67,961.60 | 1,480 | BX7RSN3 |
| 0.08% | NVAX | NOVAVAX INC | -- | $67,301.61 | 7,609 | BJDQXG4 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $66,499.65 | 2,043 | BLCD809 |
| 0.08% | QURE | UNIQURE NV | -- | $66,274.24 | 2,917 | BJFSR88 |
| 0.07% | NVCR | NOVOCURE LTD | -- | $65,013.20 | 5,243 | BYSS4X4 |
| 0.07% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $64,865.64 | 9,858 | 2100362 |
| 0.07% | ATAI | ATAIBECKLEY INC | -- | $63,938.80 | 17,005 | BWJDYK1 |
| 0.07% | TRVI | TREVI THERAPEUTICS INC | -- | $62,861.88 | 6,004 | BJH9ZN0 |
| 0.07% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $62,565.48 | 3,049 | BP7KZP7 |
| 0.07% | RLAY | RELAY THERAPEUTICS INC | -- | $62,160.90 | 8,115 | BN2R582 |
| 0.07% | ANAB | ANAPTYSBIO INC | -- | $61,443.36 | 1,296 | BDRW1L7 |
| 0.07% | RAPP | RAPPORT THERAPEUTICS INC | -- | $59,393.52 | 2,232 | BR3T9B6 |
| 0.07% | TSHA | TAYSHA GENE THERAPIES INC | -- | $57,840.75 | 12,825 | BNC1BX1 |
| 0.07% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $57,179.84 | 7,769 | BLR7H87 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $57,006.48 | 2,152 | BNFWZS4 |
| 0.06% | KOD | KODIAK SCIENCES INC | -- | $56,560.68 | 2,484 | BFXC933 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $55,250.96 | 12,472 | BMFJJ97 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $53,846.13 | 1,367 | BKLCWZ3 |
| 0.06% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $53,646.12 | 4,807 | BLB0YH0 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $52,836.00 | 5,712 | B8K7T65 |
| 0.06% | EYPT | EYEPOINT INC | -- | $52,403.52 | 3,876 | BMGS7L1 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $51,939.87 | 681 | BNSP8K3 |
| 0.06% | SVRA | SAVARA INC | -- | $51,445.80 | 9,527 | BYXGN81 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $50,734.30 | 14,015 | BL53SR3 |
| 0.06% | SEPN | SEPTERNA INC | -- | $48,920.64 | 2,096 | BQNKXX2 |
| 0.06% | VIR | VIR BIOTECHNOLOGY INC | -- | $48,464.16 | 6,514 | BK4PZ38 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $47,396.85 | 18,587 | BF0DMK7 |
| 0.05% | ORIC | ORIC PHARMACEUTICALS INC | -- | $46,785.60 | 4,560 | BKVDFF7 |
| 0.05% | VTYX | VENTYX BIOSCIENCES INC | -- | $46,606.95 | 3,341 | BMG99Y1 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $46,233.72 | 4,628 | BMCR7V2 |
| 0.05% | ZBIO | ZENAS BIOPHARMA INC | -- | $46,163.81 | 2,513 | BQB42H3 |
| 0.05% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $45,534.77 | 3,331 | BJLKVS6 |
| 0.05% | GHRS | GH RESEARCH PLC | -- | $45,476.64 | 2,904 | BP6C0S2 |
| 0.05% | CTMX | CYTOMX THERAPEUTICS INC | -- | $45,138.77 | 7,933 | BYWVTY5 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $44,944.62 | 2,373 | BMNDK09 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $43,473.17 | 1,933 | BMGTLY5 |
| 0.05% | BCAX | BICARA THERAPEUTICS INC | -- | $43,092.00 | 2,565 | BQB42F1 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $42,985.12 | 2,192 | BZ7PJQ1 |
| 0.05% | ANNX | ANNEXON INC | -- | $42,288.48 | 6,777 | BMVV9R5 |
| 0.05% | PCRX | PACIRA BIOSCIENCES INC | -- | $41,367.56 | 2,014 | B3X26D8 |
| 0.05% | GERN | GERON CORP | -- | $40,947.93 | 29,889 | 2370381 |
| 0.05% | XNCR | XENCOR INC | -- | $40,428.96 | 3,344 | BGCYWN8 |
| 0.05% | ARVN | ARVINAS INC | -- | $40,233.66 | 3,007 | BDZ30Q0 |
| 0.05% | MESO | MESOBLAST LTD- SPON ADR | -- | $39,606.00 | 2,296 | BQS7491 |
| 0.04% | PSNL | PERSONALIS INC | -- | $38,960.46 | 4,158 | BJQ0608 |
| 0.04% | OMER | OMEROS CORP | -- | $38,810.80 | 3,320 | B4NB858 |
| 0.04% | JANX | JANUX THERAPEUTICS INC | -- | $38,607.36 | 2,816 | BMFX8Y7 |
| 0.04% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $38,503.85 | 959 | BL95N25 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $37,944.27 | 11,193 | BBNBTD2 |
| 0.04% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $37,247.13 | 7,617 | B3MZ6K5 |
| 0.04% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $37,190.65 | 9,005 | BZ0QMB7 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $36,948.87 | 2,367 | BD06CS0 |
| 0.04% | CGEM | CULLINAN THERAPEUTICS INC | -- | $33,081.36 | 2,766 | BM90J52 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $33,080.88 | 4,074 | BYZD465 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $32,202.12 | 8,452 | BPBJFM7 |
| 0.04% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $31,947.36 | 14,136 | B4N8MH9 |
| 0.04% | BIOA | BIOAGE LABS INC | -- | $31,884.21 | 1,679 | BT9K6D8 |
| 0.03% | ZLAB | ZAI LAB LTD-ADR | -- | $30,427.80 | 1,833 | BD9GVY0 |
| 0.03% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $29,631.00 | 850 | BQD3J33 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $29,516.28 | 4,412 | BMC3HS7 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $28,682.09 | 3,769 | BFYQFJ2 |
| 0.03% | CRMD | CORMEDIX INC | -- | $28,626.64 | 3,689 | BJ0LT31 |
| 0.03% | ALT | ALTIMMUNE INC | -- | $27,361.60 | 4,886 | BFY7DC4 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $27,230.07 | 2,667 | BMFK3H6 |
| 0.03% | FULC | FULCRUM THERAPEUTICS INC | -- | $27,189.82 | 2,534 | BJDX8Z9 |
| 0.03% | RGNX | REGENXBIO INC | -- | $26,449.20 | 2,370 | BZ0G875 |
| 0.03% | REPL | REPLIMUNE GROUP INC | -- | $25,821.19 | 3,673 | BDDVW37 |
| 0.03% | KROS | KEROS THERAPEUTICS INC | -- | $25,539.66 | 1,426 | BM7V485 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $25,319.97 | 3,417 | BQ6C357 |
| 0.03% | GOSS | GOSSAMER BIO INC | -- | $24,708.36 | 10,837 | BJ0CK86 |
| 0.03% | LYEL | LYELL IMMUNOPHARMA INC | -- | $23,832.00 | 993 | BTNMG41 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $23,724.00 | 2,636 | BLFBZ32 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $23,700.50 | 2,675 | BKLXFX5 |
| 0.03% | SLDB | SOLID BIOSCIENCES INC | -- | $23,566.08 | 3,648 | BQHN6C7 |
| 0.03% | LENZ | LENZ THERAPEUTICS INC | -- | $23,176.30 | 1,465 | BQV0J03 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $22,936.76 | 677 | B292NQ7 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $22,814.40 | 6,790 | BMCWKZ2 |
| 0.03% | IVVD | INVIVYD INC | -- | $22,576.50 | 12,975 | BM8NHS1 |
| 0.03% | KMDA | KAMADA LTD | -- | $22,472.32 | 2,701 | B2Q9833 |
| 0.03% | SIGA | SIGA TECHNOLOGIES INC | -- | $22,465.10 | 3,353 | 2107437 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $22,201.20 | 2,520 | B91XRN2 |
| 0.02% | ABSI | ABSCI CORP | -- | $21,052.59 | 7,041 | BN94K69 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $20,863.18 | 2,767 | B12W3P6 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $20,477.60 | 1,790 | BP81RK8 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $19,660.10 | 4,183 | BYTYP72 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $19,360.48 | 10,522 | BFZNYB7 |
| 0.02% | ETON | ETON PHARMACEUTICALS INC | -- | $18,852.56 | 1,256 | BGL0JK3 |
| 0.02% | ACRS | ACLARIS THERAPEUTICS INC | -- | $17,806.23 | 5,073 | BYV2W40 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $17,608.80 | 5,060 | BDFKQ07 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $17,511.24 | 876 | BPBPCG8 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $17,427.90 | 1,351 | B9L5200 |
| 0.02% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $16,850.40 | 5,712 | BYVQJ96 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $16,648.80 | 2,973 | BP81R42 |
| 0.02% | PEPG | PEPGEN INC | -- | $16,513.47 | 3,219 | BMTX3D7 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $16,428.51 | 2,051 | BSMLR16 |
| 0.02% | NBP | NOVABRIDGE BIOSCIENCES | -- | $16,113.08 | 4,868 | BKRRKY7 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $15,567.77 | 7,823 | BN4JN37 |
| 0.02% | AVIR | ATEA PHARMACEUTICALS INC | -- | $15,509.92 | 3,658 | BLN9Z50 |
| 0.02% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $15,429.32 | 1,082 | BPRBTY7 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $15,286.32 | 2,359 | B7F2TY6 |
| 0.02% | LFCR | LIFECORE BIOMEDICAL INC | -- | $15,242.26 | 1,754 | 2517058 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $15,120.08 | 2,648 | BMF7DT9 |
| 0.02% | CADL | CANDEL THERAPEUTICS INC | -- | $15,008.80 | 2,570 | BP0TQC5 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $14,996.19 | 4,701 | BZC0D70 |
| 0.02% | EOLS | EVOLUS INC | -- | $14,234.15 | 3,035 | BDRJH21 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $14,188.32 | 4,008 | BMXNGZ6 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $13,996.49 | 3,023 | BMVBZF5 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $13,905.72 | 2,166 | BKDQKM6 |
| 0.02% | AARD | AARDVARK THERAPEUTICS INC | -- | $13,236.81 | 1,019 | BTXQTX3 |
| 0.01% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $12,867.04 | 9,392 | BFMLGR4 |
| 0.01% | NGNE | NEUROGENE INC | -- | $12,803.50 | 725 | BS2F741 |
| 0.01% | OABI | OMNIAB INC | -- | $12,266.80 | 6,740 | BN13S71 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $12,223.44 | 5,659 | BRK0149 |
| 0.01% | CABA | CABALETTA BIO INC | -- | $11,582.99 | 4,507 | BK5MWR1 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $10,760.10 | 2,759 | BY7RB53 |
| 0.01% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $10,599.18 | 2,199 | BL5B6Z1 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $10,346.28 | 9,156 | BNR5QT9 |
| 0.01% | VOR | VOR BIOPHARMA INC | -- | $10,257.00 | 789 | BRJJYT3 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $9,935.10 | 1,330 | BKC9SX3 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $9,227.56 | 2,644 | BPRB2N7 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $9,096.29 | 4,571 | BZ8FPH3 |
| 0.01% | HUMA | HUMACYTE INC | -- | $8,747.83 | 8,768 | BMYTJP4 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $8,622.20 | 4,538 | BKX9NQ0 |
| 0.01% | MENS | JYONG BIOTECH LTD | -- | $8,401.60 | 3,560 | BPTK6Z2 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $8,232.84 | 1,452 | BP2NYN2 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $6,643.32 | 2,668 | BKTV702 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $6,170.16 | 4,376 | BNYJR68 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $6,064.52 | 2,506 | BP7L561 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $6,039.56 | 7,796 | BNNXX52 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $5,526.07 | 4,567 | BNNXX18 |
| 0.01% | CDXS | CODEXIS INC | -- | $5,243.96 | 4,229 | B5LL2C2 |
| -- | PYXS | PYXIS ONCOLOGY INC | -- | $4,226.75 | 2,915 | BLBR8D5 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $14.95 | 01 | BTFHQP5 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 37.79% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 32,997,353 | -- | 5,638 | -- |
| 29.59% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 25,839,538 | -- | 4,415 | -- |
| 23.75% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 20,736,010 | -- | 3,543 | -- |
| 17.69% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 15,445,196 | -- | 2,639 | -- |
| 16.65% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,538,032 | -- | 2,484 | -- |
| 4.24% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,704,740 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $25,952,827.73 | 25,952,828 | -- |
Index
as of 12/31/2025
- Total Number of Companies262
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$7.32 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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