BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 12/31/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 1/28/2026- NAV $84.43
- NAV Change $-2.94
- Market Price $84.46
- Market Price Change $-2.91
- Trading Volume (M) 8,859
- 30-Day Median Bid Ask Spread 0.27%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 1/28/2026- NAV $84.43
- NAV Change $-2.94
- Market Price $84.46
- Market Price Change $-2.91
- Trading Volume (M) 8,859
- 30-Day Median Bid Ask Spread 0.27%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 12/31/2025
Holdings
as of 1/28/2026
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 6.38% | GILD | GILEAD SCIENCES INC | -- | $5,653,490.36 | 40,463 | 2369174 |
| 6.33% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,612,097.13 | 11,743 | 2931034 |
| 5.69% | AMGN | AMGEN INC | -- | $5,043,980.58 | 14,739 | 2023607 |
| 4.10% | REGN | REGENERON PHARMACEUTICALS | -- | $3,632,464.68 | 4,836 | 2730190 |
| 2.44% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,162,501.88 | 6,186 | B00FWN1 |
| 1.76% | INSM | INSMED INC | -- | $1,556,717.54 | 9,986 | 2614487 |
| 1.35% | BIIB | BIOGEN INC | -- | $1,200,907.27 | 6,869 | 2455965 |
| 1.30% | ARGX | ARGENX SE - ADR | -- | $1,154,127.07 | 1,363 | BDVLM39 |
| 1.21% | ILMN | ILLUMINA INC | -- | $1,072,098.44 | 7,154 | 2613990 |
| 1.06% | UTHR | UNITED THERAPEUTICS CORP | -- | $942,076.80 | 2,016 | 2430412 |
| 1.05% | INCY | INCYTE CORP | -- | $930,046.56 | 9,192 | 2471950 |
| 0.99% | RVMD | REVOLUTION MEDICINES INC | -- | $881,031.16 | 9,052 | BL71K91 |
| 0.93% | MRNA | MODERNA INC | -- | $828,627.60 | 18,292 | BGSXTS3 |
| 0.91% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $808,402.05 | 20,005 | BMVP7Y0 |
| 0.89% | MEDP | MEDPACE HOLDINGS INC | -- | $788,643.29 | 1,319 | BDCBC61 |
| 0.80% | ROIV | ROIVANT SCIENCES LTD | -- | $713,477.24 | 32,564 | BMW4NZ9 |
| 0.79% | VTRS | VIATRIS INC | -- | $699,446.16 | 53,928 | BMWS3X9 |
| 0.79% | BBIO | BRIDGEBIO PHARMA INC | -- | $699,114.78 | 9,022 | BK1KWG8 |
| 0.75% | GH | GUARDANT HEALTH INC | -- | $664,744.34 | 6,058 | BFXC911 |
| 0.72% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $639,543.75 | 2,875 | BV9G6B8 |
| 0.71% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $628,592.88 | 4,668 | 2623911 |
| 0.70% | IONS | IONIS PHARMACEUTICALS INC | -- | $621,281.28 | 7,584 | BDJ0LS6 |
| 0.64% | SNY | SANOFI-ADR | -- | $567,090.30 | 12,390 | 2964557 |
| 0.62% | BNTX | BIONTECH SE-ADR | -- | $549,901.44 | 4,734 | BK6H543 |
| 0.61% | SMMT | SUMMIT THERAPEUTICS INC | -- | $545,147.84 | 34,856 | BMTVQS7 |
| 0.60% | EXEL | EXELIXIS INC | -- | $535,553.64 | 12,554 | 2576941 |
| 0.60% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $527,822.02 | 1,063 | BD59BS7 |
| 0.59% | TEM | TEMPUS AI INC | -- | $522,629.58 | 8,094 | BSLSJJ0 |
| 0.58% | ONC | BEONE MEDICINES LTD-ADR | -- | $515,900.00 | 1,474 | BYYWPW6 |
| 0.58% | RNA | AVIDITY BIOSCIENCES INC | -- | $511,205.30 | 7,055 | BMWHPY1 |
| 0.58% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $509,836.60 | 8,995 | 2437071 |
| 0.53% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $470,591.45 | 2,845 | B4Q5ZN4 |
| 0.49% | AXSM | AXSOME THERAPEUTICS INC | -- | $437,001.20 | 2,360 | BYZR4X4 |
| 0.47% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $417,023.22 | 6,359 | BYQBFJ8 |
| 0.45% | HALO | HALOZYME THERAPEUTICS INC | -- | $401,001.98 | 5,506 | 2975098 |
| 0.42% | CYTK | CYTOKINETICS INC | -- | $372,926.50 | 5,725 | BBBSBJ5 |
| 0.42% | KRYS | KRYSTAL BIOTECH INC | -- | $370,611.78 | 1,358 | BD6JX35 |
| 0.41% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $362,916.32 | 1,171 | BQ721R4 |
| 0.39% | CAI | CARIS LIFE SCIENCES INC | -- | $350,091.50 | 13,211 | BT18HP9 |
| 0.38% | NUVL | NUVALENT INC-A | -- | $339,113.14 | 3,382 | BMVBZD3 |
| 0.36% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $320,843.75 | 3,125 | BF2YWG4 |
| 0.36% | ABVX | ABIVAX SA-ADR | -- | $315,040.72 | 2,764 | BLC89B2 |
| 0.36% | PCVX | VAXCYTE INC | -- | $314,846.73 | 6,129 | BKPVGH6 |
| 0.32% | PTCT | PTC THERAPEUTICS INC | -- | $284,180.40 | 3,759 | B17VCN9 |
| 0.32% | IBRX | IMMUNITYBIO INC | -- | $283,625.70 | 46,118 | BNSP0B8 |
| 0.31% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $278,637.45 | 3,129 | BQS9486 |
| 0.31% | COGT | COGENT BIOSCIENCES INC | -- | $275,693.32 | 7,187 | BLR6XK8 |
| 0.30% | ALKS | ALKERMES PLC | -- | $262,080.90 | 7,731 | B3P6D26 |
| 0.27% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $242,645.10 | 2,406 | BJDX8Y8 |
| 0.27% | KYMR | KYMERA THERAPEUTICS INC | -- | $239,738.04 | 3,369 | BMPRZV5 |
| 0.27% | CRSP | CRISPR THERAPEUTICS AG | -- | $239,564.78 | 4,462 | BDHF4K6 |
| 0.27% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $239,311.52 | 2,927 | BDCBCD8 |
| 0.26% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $228,014.76 | 4,443 | BDD19F8 |
| 0.24% | IMVT | IMMUNOVANT INC | -- | $213,874.42 | 8,207 | BJRFSB7 |
| 0.23% | FOLD | AMICUS THERAPEUTICS INC | -- | $206,288.88 | 14,446 | B19FQ48 |
| 0.23% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $205,988.88 | 4,776 | BFZQ0L8 |
| 0.23% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $205,330.05 | 14,719 | BFNF1D6 |
| 0.23% | -- | INDIVIOR PHARMACEUTICALS INC COMMON STOCK USD 0.001 | -- | $204,130.92 | 5,844 | -- |
| 0.23% | CGON | CG ONCOLOGY INC | -- | $203,353.68 | 3,777 | BRBCSP4 |
| 0.23% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $202,936.02 | 7,921 | 2713317 |
| 0.21% | ACLX | ARCELLX INC | -- | $184,454.98 | 2,707 | BPCJ1Q2 |
| 0.21% | GRAL | GRAIL INC | -- | $184,325.00 | 1,825 | BSLSSX7 |
| 0.21% | ADMA | ADMA BIOLOGICS INC | -- | $181,981.52 | 11,144 | B9NSBM2 |
| 0.20% | APGE | APOGEE THERAPEUTICS INC | -- | $181,461.23 | 2,567 | BM9HHL5 |
| 0.20% | LGND | LIGAND PHARMACEUTICALS | -- | $175,382.84 | 922 | 2501578 |
| 0.19% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $169,250.92 | 5,309 | BP8JSP4 |
| 0.17% | XENE | XENON PHARMACEUTICALS INC | -- | $151,775.10 | 3,618 | BRJ3GY4 |
| 0.16% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $145,955.75 | 5,735 | BKX9VD3 |
| 0.16% | TERN | TERNS PHARMACEUTICALS INC | -- | $144,508.68 | 4,218 | BMDJ0C9 |
| 0.16% | DNLI | DENALI THERAPEUTICS INC | -- | $143,108.28 | 6,867 | BD2B4V0 |
| 0.16% | VCYT | VERACYTE INC | -- | $142,414.48 | 3,701 | BFTWZY0 |
| 0.16% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $142,166.76 | 4,957 | BKY5JZ8 |
| 0.16% | IRON | DISC MEDICINE INC | -- | $141,457.68 | 1,768 | BMGJZJ8 |
| 0.16% | IDYA | IDEAYA BIOSCIENCES INC | -- | $138,133.25 | 4,105 | BK0VHF6 |
| 0.16% | BEAM | BEAM THERAPEUTICS INC | -- | $137,874.02 | 4,751 | BK6L288 |
| 0.15% | APLS | APELLIS PHARMACEUTICALS INC | -- | $136,597.47 | 5,921 | BYTQ6X1 |
| 0.15% | VERA | VERA THERAPEUTICS INC | -- | $134,924.01 | 2,991 | BL55460 |
| 0.15% | ERAS | ERASCA INC | -- | $134,566.92 | 13,284 | BNLYBF3 |
| 0.15% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $132,238.00 | 7,148 | BJ5FZ74 |
| 0.15% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $131,403.90 | 2,685 | B72ZBG4 |
| 0.14% | TARS | TARSUS PHARMACEUTICALS INC | -- | $127,589.84 | 1,988 | BMH5RL1 |
| 0.14% | TVTX | TRAVERE THERAPEUTICS INC | -- | $126,842.92 | 4,189 | BLFGJD5 |
| 0.14% | ALMS | ALUMIS INC | -- | $126,135.92 | 4,552 | BPLQG36 |
| 0.14% | SYRE | SPYRE THERAPEUTICS INC | -- | $120,397.62 | 3,633 | BQBBDY8 |
| 0.14% | TWST | TWIST BIOSCIENCE CORP | -- | $120,274.63 | 2,863 | BGKG6G7 |
| 0.14% | MLYS | MINERALYS THERAPEUTICS INC | -- | $119,819.70 | 3,705 | BP9N0G0 |
| 0.13% | DYN | DYNE THERAPEUTICS INC | -- | $118,359.90 | 6,687 | BN15WD1 |
| 0.13% | TXG | 10X GENOMICS INC-CLASS A | -- | $114,970.32 | 5,454 | BKS3RS7 |
| 0.13% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $114,009.08 | 4,517 | BLB0YQ9 |
| 0.12% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $110,395.48 | 4,517 | BJ62Z18 |
| 0.12% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $107,615.25 | 24,075 | BM9FJ13 |
| 0.12% | SRPT | SAREPTA THERAPEUTICS INC | -- | $104,546.86 | 4,906 | B8DPDT7 |
| 0.12% | OCUL | OCULAR THERAPEUTIX INC | -- | $102,543.00 | 9,975 | BNZB1X8 |
| 0.11% | WVE | WAVE LIFE SCIENCES LTD | -- | $99,688.63 | 7,831 | BYZG9R0 |
| 0.11% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $99,357.48 | 2,697 | BKSGZN7 |
| 0.11% | MAZE | MAZE THERAPEUTICS INC | -- | $97,690.08 | 2,253 | BSRK699 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $91,537.20 | 2,115 | BRXB0C0 |
| 0.10% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $90,491.31 | 3,683 | BMZ4LN0 |
| 0.10% | GMAB | GENMAB A/S -SP ADR | -- | $90,129.41 | 2,737 | BBC9WC7 |
| 0.10% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $89,940.61 | 6,173 | BFWLC09 |
| 0.10% | ARDX | ARDELYX INC | -- | $89,423.22 | 11,377 | BN89V40 |
| 0.10% | SION | SIONNA THERAPEUTICS INC | -- | $88,051.70 | 2,090 | BQKXDX4 |
| 0.10% | VCEL | VERICEL CORP | -- | $85,721.60 | 2,368 | BSBMN89 |
| 0.10% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $85,109.04 | 5,498 | BRJZSK0 |
| 0.10% | NRIX | NURIX THERAPEUTICS INC | -- | $84,811.02 | 4,746 | BMVLGP2 |
| 0.09% | ANIP | ANI PHARMACEUTICALS INC | -- | $83,644.52 | 1,052 | BCDWBX6 |
| 0.09% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $83,638.50 | 4,070 | BN7Q7R7 |
| 0.09% | PHVS | PHARVARIS NV | -- | $83,552.14 | 2,999 | BMZ2X38 |
| 0.09% | MNKD | MANNKIND CORP | -- | $81,091.92 | 14,378 | BF081J4 |
| 0.09% | ORKA | ORUKA THERAPEUTICS INC | -- | $79,707.72 | 2,267 | BKVF0J2 |
| 0.09% | STOK | STOKE THERAPEUTICS INC | -- | $78,645.00 | 2,675 | BJQ05Z6 |
| 0.09% | ZYME | ZYMEWORKS INC | -- | $78,174.24 | 3,504 | BPCQZY9 |
| 0.09% | TYRA | TYRA BIOSCIENCES INC | -- | $77,668.92 | 2,499 | BMVNDH9 |
| 0.09% | -- | DEFINIUM THERAPEUTICS INC COMMON STOCK USD 0 | -- | $77,666.08 | 4,612 | -- |
| 0.09% | ALVO | ALVOTECH SA | -- | $77,530.24 | 14,656 | BPNTJ34 |
| 0.09% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $77,286.30 | 2,730 | BCBVTX1 |
| 0.09% | UPB | UPSTREAM BIO INC | -- | $76,987.90 | 2,530 | BRCFFK6 |
| 0.08% | MBX | MBX BIOSCIENCES INC | -- | $75,314.66 | 2,102 | BQXJKH2 |
| 0.08% | NTLA | INTELLIA THERAPEUTICS INC | -- | $74,945.86 | 5,423 | BYZM6C2 |
| 0.08% | RAPT | RAPT THERAPEUTICS INC | -- | $74,772.05 | 1,297 | BTJZB49 |
| 0.08% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $74,584.71 | 5,142 | BPCK358 |
| 0.08% | PGEN | PRECIGEN INC | -- | $73,888.82 | 16,567 | BKM5C84 |
| 0.08% | HROW | HARROW INC | -- | $73,851.06 | 1,734 | BHNDW86 |
| 0.08% | FTRE | FORTREA HOLDINGS INC | -- | $72,373.98 | 4,326 | BRXYZ57 |
| 0.08% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $71,828.38 | 3,497 | BYP80F1 |
| 0.08% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $70,531.02 | 2,779 | BMFD115 |
| 0.08% | TNGX | TANGO THERAPEUTICS INC | -- | $70,501.08 | 6,306 | BP2P6L0 |
| 0.08% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $70,364.70 | 3,942 | BMX9K07 |
| 0.08% | NVAX | NOVAVAX INC | -- | $70,231.07 | 7,609 | BJDQXG4 |
| 0.08% | INVA | INNOVIVA INC | -- | $68,444.55 | 3,501 | BDDXF67 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $67,684.59 | 2,043 | BLCD809 |
| 0.08% | QURE | UNIQURE NV | -- | $67,149.34 | 2,917 | BJFSR88 |
| 0.07% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $66,333.60 | 1,480 | BX7RSN3 |
| 0.07% | NVCR | NOVOCURE LTD | -- | $65,956.94 | 5,243 | BYSS4X4 |
| 0.07% | ATAI | ATAIBECKLEY INC | -- | $65,809.35 | 17,005 | BWJDYK1 |
| 0.07% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $65,654.28 | 9,858 | 2100362 |
| 0.07% | KOD | KODIAK SCIENCES INC | -- | $64,757.88 | 2,484 | BFXC933 |
| 0.07% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $64,425.37 | 3,049 | BP7KZP7 |
| 0.07% | TRVI | TREVI THERAPEUTICS INC | -- | $63,102.04 | 6,004 | BJH9ZN0 |
| 0.07% | RLAY | RELAY THERAPEUTICS INC | -- | $62,079.75 | 8,115 | BN2R582 |
| 0.07% | ANAB | ANAPTYSBIO INC | -- | $61,495.20 | 1,296 | BDRW1L7 |
| 0.07% | SANA | SANA BIOTECHNOLOGY INC | -- | $59,242.00 | 12,472 | BMFJJ97 |
| 0.07% | RAPP | RAPPORT THERAPEUTICS INC | -- | $59,014.08 | 2,232 | BR3T9B6 |
| 0.07% | EYPT | EYEPOINT INC | -- | $58,295.04 | 3,876 | BMGS7L1 |
| 0.06% | TSHA | TAYSHA GENE THERAPIES INC | -- | $57,456.00 | 12,825 | BNC1BX1 |
| 0.06% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $56,626.46 | 4,807 | BLB0YH0 |
| 0.06% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $56,210.24 | 2,152 | BNFWZS4 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $55,626.04 | 7,769 | BLR7H87 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $54,658.50 | 14,015 | BL53SR3 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $54,010.17 | 1,367 | BKLCWZ3 |
| 0.06% | ZBIO | ZENAS BIOPHARMA INC | -- | $53,954.11 | 2,513 | BQB42H3 |
| 0.06% | SVRA | SAVARA INC | -- | $53,446.47 | 9,527 | BYXGN81 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $52,493.28 | 5,712 | B8K7T65 |
| 0.06% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $51,114.25 | 18,587 | BF0DMK7 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $50,380.38 | 681 | BNSP8K3 |
| 0.06% | ORIC | ORIC PHARMACEUTICALS INC | -- | $50,068.80 | 4,560 | BKVDFF7 |
| 0.06% | SEPN | SEPTERNA INC | -- | $49,591.36 | 2,096 | BQNKXX2 |
| 0.06% | VIR | VIR BIOTECHNOLOGY INC | -- | $49,310.98 | 6,514 | BK4PZ38 |
| 0.05% | CTMX | CYTOMX THERAPEUTICS INC | -- | $46,804.70 | 7,933 | BYWVTY5 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $46,733.44 | 2,192 | BZ7PJQ1 |
| 0.05% | VTYX | VENTYX BIOSCIENCES INC | -- | $46,673.77 | 3,341 | BMG99Y1 |
| 0.05% | GHRS | GH RESEARCH PLC | -- | $46,638.24 | 2,904 | BP6C0S2 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $46,557.68 | 4,628 | BMCR7V2 |
| 0.05% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $46,101.04 | 3,331 | BJLKVS6 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $45,158.19 | 2,373 | BMNDK09 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $43,627.81 | 1,933 | BMGTLY5 |
| 0.05% | MESO | MESOBLAST LTD- SPON ADR | -- | $42,935.20 | 2,296 | BQS7491 |
| 0.05% | ANNX | ANNEXON INC | -- | $42,627.33 | 6,777 | BMVV9R5 |
| 0.05% | BCAX | BICARA THERAPEUTICS INC | -- | $42,553.35 | 2,565 | BQB42F1 |
| 0.05% | PSNL | PERSONALIS INC | -- | $41,538.42 | 4,158 | BJQ0608 |
| 0.05% | XNCR | XENCOR INC | -- | $41,298.40 | 3,344 | BGCYWN8 |
| 0.05% | PCRX | PACIRA BIOSCIENCES INC | -- | $41,045.32 | 2,014 | B3X26D8 |
| 0.04% | GERN | GERON CORP | -- | $39,752.37 | 29,889 | 2370381 |
| 0.04% | JANX | JANUX THERAPEUTICS INC | -- | $39,283.20 | 2,816 | BMFX8Y7 |
| 0.04% | OMER | OMEROS CORP | -- | $39,209.20 | 3,320 | B4NB858 |
| 0.04% | ARVN | ARVINAS INC | -- | $38,880.51 | 3,007 | BDZ30Q0 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $38,727.78 | 11,193 | BBNBTD2 |
| 0.04% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $37,280.70 | 9,005 | BZ0QMB7 |
| 0.04% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $37,209.20 | 959 | BL95N25 |
| 0.04% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $36,485.43 | 7,617 | B3MZ6K5 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $35,836.38 | 2,367 | BD06CS0 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $34,061.56 | 8,452 | BPBJFM7 |
| 0.04% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $33,643.68 | 14,136 | B4N8MH9 |
| 0.04% | CGEM | CULLINAN THERAPEUTICS INC | -- | $32,777.10 | 2,766 | BM90J52 |
| 0.04% | BIOA | BIOAGE LABS INC | -- | $32,757.29 | 1,679 | BT9K6D8 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $32,754.96 | 4,074 | BYZD465 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $31,527.60 | 1,833 | BD9GVY0 |
| 0.03% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $29,962.50 | 850 | BQD3J33 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $29,604.52 | 4,412 | BMC3HS7 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $29,247.44 | 3,769 | BFYQFJ2 |
| 0.03% | CRMD | CORMEDIX INC | -- | $28,589.75 | 3,689 | BJ0LT31 |
| 0.03% | GOSS | GOSSAMER BIO INC | -- | $27,634.35 | 10,837 | BJ0CK86 |
| 0.03% | LENZ | LENZ THERAPEUTICS INC | -- | $27,322.25 | 1,465 | BQV0J03 |
| 0.03% | REPL | REPLIMUNE GROUP INC | -- | $27,033.28 | 3,673 | BDDVW37 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $27,016.71 | 2,667 | BMFK3H6 |
| 0.03% | FULC | FULCRUM THERAPEUTICS INC | -- | $26,556.32 | 2,534 | BJDX8Z9 |
| 0.03% | RGNX | REGENXBIO INC | -- | $26,093.70 | 2,370 | BZ0G875 |
| 0.03% | KROS | KEROS THERAPEUTICS INC | -- | $25,425.58 | 1,426 | BM7V485 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $25,422.48 | 3,417 | BQ6C357 |
| 0.03% | ALT | ALTIMMUNE INC | -- | $25,016.32 | 4,886 | BFY7DC4 |
| 0.03% | IVVD | INVIVYD INC | -- | $24,912.00 | 12,975 | BM8NHS1 |
| 0.03% | SLDB | SOLID BIOSCIENCES INC | -- | $23,894.40 | 3,648 | BQHN6C7 |
| 0.03% | LYEL | LYELL IMMUNOPHARMA INC | -- | $23,861.79 | 993 | BTNMG41 |
| 0.03% | KMDA | KAMADA LTD | -- | $23,336.64 | 2,701 | B2Q9833 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $23,221.80 | 6,790 | BMCWKZ2 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $23,085.70 | 677 | B292NQ7 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $23,032.80 | 2,520 | B91XRN2 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $23,005.00 | 2,675 | BKLXFX5 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $22,748.68 | 2,636 | BLFBZ32 |
| 0.03% | SIGA | SIGA TECHNOLOGIES INC | -- | $22,364.51 | 3,353 | 2107437 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $21,278.23 | 2,767 | B12W3P6 |
| 0.02% | ABSI | ABSCI CORP | -- | $20,700.54 | 7,041 | BN94K69 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $20,371.21 | 4,183 | BYTYP72 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $19,958.50 | 1,790 | BP81RK8 |
| 0.02% | NBP | NOVABRIDGE BIOSCIENCES | -- | $18,839.16 | 4,868 | BKRRKY7 |
| 0.02% | ETON | ETON PHARMACEUTICALS INC | -- | $18,538.56 | 1,256 | BGL0JK3 |
| 0.02% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $18,506.88 | 5,712 | BYVQJ96 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $18,114.80 | 5,060 | BDFKQ07 |
| 0.02% | ACRS | ACLARIS THERAPEUTICS INC | -- | $17,806.23 | 5,073 | BYV2W40 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $17,336.04 | 876 | BPBPCG8 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $17,187.38 | 2,051 | BSMLR16 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $17,090.15 | 1,351 | B9L5200 |
| 0.02% | PEPG | PEPGEN INC | -- | $16,803.18 | 3,219 | BMTX3D7 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $16,312.47 | 4,701 | BZC0D70 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $16,113.66 | 2,973 | BP81R42 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $15,958.92 | 7,823 | BN4JN37 |
| 0.02% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $15,613.26 | 1,082 | BPRBTY7 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $15,543.76 | 2,648 | BMF7DT9 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $15,256.90 | 10,522 | BFZNYB7 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $15,115.00 | 3,023 | BMVBZF5 |
| 0.02% | LFCR | LIFECORE BIOMEDICAL INC | -- | $15,014.24 | 1,754 | 2517058 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $14,908.88 | 2,359 | B7F2TY6 |
| 0.02% | CADL | CANDEL THERAPEUTICS INC | -- | $14,751.80 | 2,570 | BP0TQC5 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $14,749.44 | 4,008 | BMXNGZ6 |
| 0.02% | EOLS | EVOLUS INC | -- | $14,568.00 | 3,035 | BDRJH21 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $14,252.28 | 2,166 | BKDQKM6 |
| 0.02% | AVIR | ATEA PHARMACEUTICALS INC | -- | $14,156.46 | 3,658 | BLN9Z50 |
| 0.02% | NGNE | NEUROGENE INC | -- | $13,970.75 | 725 | BS2F741 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $13,618.40 | 9,392 | BFMLGR4 |
| 0.02% | AARD | AARDVARK THERAPEUTICS INC | -- | $13,501.75 | 1,019 | BTXQTX3 |
| 0.01% | CABA | CABALETTA BIO INC | -- | $12,844.95 | 4,507 | BK5MWR1 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $12,534.69 | 5,659 | BRK0149 |
| 0.01% | OABI | OMNIAB INC | -- | $12,469.00 | 6,740 | BN13S71 |
| 0.01% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $11,016.99 | 2,199 | BL5B6Z1 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $10,987.20 | 9,156 | BNR5QT9 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $10,953.23 | 2,759 | BY7RB53 |
| 0.01% | VOR | VOR BIOPHARMA INC | -- | $10,840.86 | 789 | BRJJYT3 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $10,390.92 | 2,644 | BPRB2N7 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $9,802.10 | 1,330 | BKC9SX3 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $9,416.26 | 4,571 | BZ8FPH3 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $9,212.14 | 4,538 | BKX9NQ0 |
| 0.01% | MENS | JYONG BIOTECH LTD | -- | $9,006.80 | 3,560 | BPTK6Z2 |
| 0.01% | HUMA | HUMACYTE INC | -- | $8,768.00 | 8,768 | BMYTJP4 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $8,501.46 | 1,452 | BP2NYN2 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $7,442.82 | 2,506 | BP7L561 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $6,856.76 | 2,668 | BKTV702 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $6,651.52 | 4,376 | BNYJR68 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $6,119.78 | 4,567 | BNNXX18 |
| 0.01% | CDXS | CODEXIS INC | -- | $5,455.41 | 4,229 | B5LL2C2 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $5,145.36 | 7,796 | BNNXX52 |
| -- | PYXS | PYXIS ONCOLOGY INC | -- | $4,401.65 | 2,915 | BLBR8D5 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $15.61 | 01 | BTFHQP5 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 39.34% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 34,874,347 | -- | 5,916 | -- |
| 29.36% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 26,026,072 | -- | 4,415 | -- |
| 23.79% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 21,086,129 | -- | 3,577 | -- |
| 17.55% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 15,556,694 | -- | 2,639 | -- |
| 16.52% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,642,981 | -- | 2,484 | -- |
| 4.21% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,731,484 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $26,836,608.89 | 26,836,609 | -- |
Index
as of 12/31/2025
- Total Number of Companies262
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$7.32 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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