BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 9/30/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 10/17/2025- NAV $67.02
- NAV Change $+0.73
- Market Price $67.02
- Market Price Change $+0.80
- Trading Volume (M) 12,679
- 30-Day Median Bid Ask Spread 0.26%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 10/17/2025- NAV $67.02
- NAV Change $+0.73
- Market Price $67.02
- Market Price Change $+0.80
- Trading Volume (M) 12,679
- 30-Day Median Bid Ask Spread 0.26%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 10/17/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.12% | GILD | GILEAD SCIENCES INC | -- | $3,360,941.27 | 27,367 | 2369174 |
| 5.02% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $3,295,716.67 | 7,907 | 2931034 |
| 4.89% | AMGN | AMGEN INC | -- | $3,211,012.26 | 10,746 | 2023607 |
| 3.56% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,339,471.19 | 4,857 | B00FWN1 |
| 3.40% | REGN | REGENERON PHARMACEUTICALS | -- | $2,231,273.00 | 3,860 | 2730190 |
| 2.50% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $1,638,582.12 | 19,348 | 2989044 |
| 1.99% | INSM | INSMED INC | -- | $1,309,006.72 | 7,897 | 2614487 |
| 1.47% | ARGX | ARGENX SE - ADR | -- | $965,147.04 | 1,144 | BDVLM39 |
| 1.19% | BIIB | BIOGEN INC | -- | $783,354.00 | 5,478 | 2455965 |
| 1.12% | UTHR | UNITED THERAPEUTICS CORP | -- | $732,344.60 | 1,690 | 2430412 |
| 0.97% | INCY | INCYTE CORP | -- | $638,910.72 | 7,296 | 2471950 |
| 0.91% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $597,748.51 | 16,151 | BMVP7Y0 |
| 0.89% | SMMT | SUMMIT THERAPEUTICS INC | -- | $582,535.47 | 27,753 | BMTVQS7 |
| 0.84% | MEDP | MEDPACE HOLDINGS INC | -- | $553,945.43 | 1,049 | BDCBC61 |
| 0.84% | TEM | TEMPUS AI INC | -- | $553,277.34 | 6,303 | BSLSJJ0 |
| 0.83% | ILMN | ILLUMINA INC | -- | $548,131.32 | 5,742 | 2613990 |
| 0.79% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $519,033.45 | 3,705 | 2623911 |
| 0.77% | SNY | SANOFI-ADR | -- | $507,414.88 | 10,024 | 2964557 |
| 0.73% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $478,466.50 | 2,273 | BV9G6B8 |
| 0.67% | VTRS | VIATRIS INC | -- | $442,984.86 | 43,558 | BMWS3X9 |
| 0.67% | ROIV | ROIVANT SCIENCES LTD | -- | $440,354.38 | 25,513 | BMW4NZ9 |
| 0.66% | IONS | IONIS PHARMACEUTICALS INC | -- | $435,250.95 | 5,955 | BDJ0LS6 |
| 0.60% | ONC | BEONE MEDICINES LTD-ADR | -- | $397,107.10 | 1,255 | BYYWPW6 |
| 0.60% | BNTX | BIONTECH SE-ADR | -- | $395,116.12 | 3,758 | BK6H543 |
| 0.60% | EXEL | EXELIXIS INC | -- | $394,776.50 | 10,058 | 2576941 |
| 0.60% | BBIO | BRIDGEBIO PHARMA INC | -- | $392,293.56 | 7,143 | BK1KWG8 |
| 0.58% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $382,302.46 | 7,174 | 2437071 |
| 0.58% | MRNA | MODERNA INC | -- | $378,081.36 | 14,536 | BGSXTS3 |
| 0.58% | RVMD | REVOLUTION MEDICINES INC | -- | $377,834.40 | 6,984 | BL71K91 |
| 0.56% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $365,603.70 | 833 | BD59BS7 |
| 0.47% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $308,311.96 | 2,266 | B4Q5ZN4 |
| 0.46% | GH | GUARDANT HEALTH INC | -- | $304,978.14 | 4,659 | BFXC911 |
| 0.45% | HALO | HALOZYME THERAPEUTICS INC | -- | $292,921.10 | 4,370 | 2975098 |
| 0.42% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $273,604.68 | 2,481 | BF2YWG4 |
| 0.41% | MRUS | MERUS NV | -- | $268,159.14 | 2,826 | BZBY005 |
| 0.40% | CYTK | CYTOKINETICS INC | -- | $261,226.80 | 4,470 | BBBSBJ5 |
| 0.36% | AXSM | AXSOME THERAPEUTICS INC | -- | $238,480.16 | 1,864 | BYZR4X4 |
| 0.36% | CRSP | CRISPR THERAPEUTICS AG | -- | $234,971.70 | 3,398 | BDHF4K6 |
| 0.35% | NUVL | NUVALENT INC-A | -- | $230,467.32 | 2,491 | BMVBZD3 |
| 0.35% | RNA | AVIDITY BIOSCIENCES INC | -- | $230,159.34 | 4,806 | BMWHPY1 |
| 0.31% | KRYS | KRYSTAL BIOTECH INC | -- | $205,828.86 | 1,082 | BD6JX35 |
| 0.31% | PCVX | VAXCYTE INC | -- | $205,591.50 | 4,850 | BKPVGH6 |
| 0.30% | PTCT | PTC THERAPEUTICS INC | -- | $195,739.60 | 2,968 | B17VCN9 |
| 0.29% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $190,123.65 | 5,165 | BYQBFJ8 |
| 0.28% | ALKS | ALKERMES PLC | -- | $186,643.68 | 6,168 | B3P6D26 |
| 0.27% | ACLX | ARCELLX INC | -- | $180,243.28 | 2,072 | BPCJ1Q2 |
| 0.27% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $180,110.00 | 2,324 | BDCBCD8 |
| 0.24% | AKRO | AKERO THERAPEUTICS INC | -- | $160,873.92 | 2,988 | BK7Y2V9 |
| 0.24% | KYMR | KYMERA THERAPEUTICS INC | -- | $159,805.93 | 2,671 | BMPRZV5 |
| 0.23% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $153,171.20 | 4,208 | BP8JSP4 |
| 0.23% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $149,332.14 | 786 | BQ721R4 |
| 0.22% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $146,451.11 | 3,523 | BDD19F8 |
| 0.21% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $138,015.81 | 1,877 | BJDX8Y8 |
| 0.20% | LGND | LIGAND PHARMACEUTICALS | -- | $132,967.80 | 732 | 2501578 |
| 0.20% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $131,690.56 | 6,304 | 2713317 |
| 0.19% | ADMA | ADMA BIOLOGICS INC | -- | $128,019.40 | 8,915 | B9NSBM2 |
| 0.18% | XENE | XENON PHARMACEUTICALS INC | -- | $119,936.03 | 2,881 | BRJ3GY4 |
| 0.18% | QURE | UNIQURE NV | -- | $118,900.00 | 2,050 | BJFSR88 |
| 0.18% | CGON | CG ONCOLOGY INC | -- | $118,119.54 | 2,849 | BRBCSP4 |
| 0.18% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $117,518.64 | 3,601 | BJ62Z18 |
| 0.18% | IRON | DISC MEDICINE INC | -- | $116,832.06 | 1,299 | BMGJZJ8 |
| 0.18% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $116,401.28 | 11,734 | BFNF1D6 |
| 0.18% | APLS | APELLIS PHARMACEUTICALS INC | -- | $115,685.36 | 4,718 | BYTQ6X1 |
| 0.18% | TARS | TARSUS PHARMACEUTICALS INC | -- | $115,010.61 | 1,577 | BMH5RL1 |
| 0.17% | INDV | INDIVIOR PLC | -- | $114,101.28 | 4,661 | BP0BQQ5 |
| 0.17% | IMVT | IMMUNOVANT INC | -- | $114,042.63 | 6,513 | BJRFSB7 |
| 0.16% | MLYS | MINERALYS THERAPEUTICS INC | -- | $107,854.56 | 2,476 | BP9N0G0 |
| 0.16% | VCYT | VERACYTE INC | -- | $105,340.20 | 2,940 | BFTWZY0 |
| 0.16% | GRAL | GRAIL INC | -- | $105,066.00 | 1,347 | BSLSSX7 |
| 0.16% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $105,055.98 | 2,094 | B72ZBG4 |
| 0.16% | ALVO | ALVOTECH SA | -- | $101,971.68 | 11,694 | BPNTJ34 |
| 0.15% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $100,546.16 | 3,146 | BMX9K07 |
| 0.15% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $100,360.48 | 3,592 | BFZQ0L8 |
| 0.15% | NTLA | INTELLIA THERAPEUTICS INC | -- | $99,247.50 | 4,010 | BYZM6C2 |
| 0.15% | BEAM | BEAM THERAPEUTICS INC | -- | $98,204.40 | 3,780 | BK6L288 |
| 0.15% | IDYA | IDEAYA BIOSCIENCES INC | -- | $95,826.50 | 3,275 | BK0VHF6 |
| 0.14% | APGE | APOGEE THERAPEUTICS INC | -- | $95,023.45 | 1,723 | BM9HHL5 |
| 0.14% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $93,549.04 | 15,964 | BM9FJ13 |
| 0.14% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $93,521.52 | 4,479 | BKX9VD3 |
| 0.14% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $92,730.70 | 5,689 | BJ5FZ74 |
| 0.14% | FOLD | AMICUS THERAPEUTICS INC | -- | $92,588.64 | 11,516 | B19FQ48 |
| 0.14% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $91,898.43 | 2,171 | BCBVTX1 |
| 0.14% | DNLI | DENALI THERAPEUTICS INC | -- | $91,013.58 | 5,463 | BD2B4V0 |
| 0.14% | TVTX | TRAVERE THERAPEUTICS INC | -- | $91,002.92 | 3,331 | BLFGJD5 |
| 0.13% | DYN | DYNE THERAPEUTICS INC | -- | $87,059.70 | 5,315 | BN15WD1 |
| 0.13% | COGT | COGENT BIOSCIENCES INC | -- | $85,539.41 | 5,219 | BLR6XK8 |
| 0.13% | IBRX | IMMUNITYBIO INC | -- | $84,756.00 | 35,315 | BNSP0B8 |
| 0.13% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $82,526.70 | 3,585 | BLB0YQ9 |
| 0.13% | SRPT | SAREPTA THERAPEUTICS INC | -- | $82,184.01 | 3,651 | B8DPDT7 |
| 0.12% | ETNB | 89BIO INC | -- | $81,785.16 | 5,541 | BK1K484 |
| 0.12% | OCUL | OCULAR THERAPEUTIX INC | -- | $76,971.84 | 6,501 | BNZB1X8 |
| 0.12% | ANIP | ANI PHARMACEUTICALS INC | -- | $76,874.69 | 811 | BCDWBX6 |
| 0.11% | VERA | VERA THERAPEUTICS INC | -- | $74,483.55 | 2,385 | BL55460 |
| 0.10% | STOK | STOKE THERAPEUTICS INC | -- | $68,669.44 | 2,048 | BJQ05Z6 |
| 0.10% | VCEL | VERICEL CORP | -- | $66,578.20 | 1,885 | BSBMN89 |
| 0.10% | TWST | TWIST BIOSCIENCE CORP | -- | $63,500.80 | 2,255 | BGKG6G7 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $62,751.36 | 1,624 | BRXB0C0 |
| 0.10% | MNKD | MANNKIND CORP | -- | $62,708.08 | 11,464 | BF081J4 |
| 0.10% | ABCL | ABCELLERA BIOLOGICS INC | -- | $62,412.35 | 11,165 | BL53SR3 |
| 0.09% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $60,947.88 | 2,226 | BQS9486 |
| 0.09% | JANX | JANUX THERAPEUTICS INC | -- | $60,076.20 | 2,245 | BMFX8Y7 |
| 0.09% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $59,411.70 | 3,945 | BKY5JZ8 |
| 0.09% | NVCR | NOVOCURE LTD | -- | $57,559.06 | 4,177 | BYSS4X4 |
| 0.09% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $56,802.90 | 4,918 | BFWLC09 |
| 0.08% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $55,744.92 | 6,033 | BLR7H87 |
| 0.08% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $55,659.10 | 2,149 | BKSGZN7 |
| 0.08% | HROW | HARROW INC | -- | $55,293.82 | 1,382 | BHNDW86 |
| 0.08% | AVDL | AVADEL PHARMACEUTICALS | -- | $55,202.94 | 3,627 | BDGMC59 |
| 0.08% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $51,999.09 | 7,843 | 2100362 |
| 0.08% | GMAB | GENMAB A/S -SP ADR | -- | $51,944.22 | 1,566 | BBC9WC7 |
| 0.08% | ZYME | ZYMEWORKS INC | -- | $51,685.60 | 2,809 | BPCQZY9 |
| 0.08% | SYRE | SPYRE THERAPEUTICS INC | -- | $50,714.79 | 2,257 | BQBBDY8 |
| 0.08% | TXG | 10X GENOMICS INC-CLASS A | -- | $50,561.42 | 4,274 | BKS3RS7 |
| 0.08% | ZLAB | ZAI LAB LTD-ADR | -- | $50,554.23 | 1,787 | BD9GVY0 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $50,205.76 | 1,496 | BLCD809 |
| 0.08% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $49,813.40 | 3,332 | BPCK358 |
| 0.07% | NVAX | NOVAVAX INC | -- | $49,150.80 | 6,068 | BJDQXG4 |
| 0.07% | SANA | SANA BIOTECHNOLOGY INC | -- | $48,619.98 | 9,666 | BMFJJ97 |
| 0.07% | TSHA | TAYSHA GENE THERAPIES INC | -- | $48,106.24 | 10,192 | BNC1BX1 |
| 0.07% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $47,380.33 | 2,213 | BMFD115 |
| 0.07% | TRVI | TREVI THERAPEUTICS INC | -- | $47,138.00 | 4,550 | BJH9ZN0 |
| 0.07% | WVE | WAVE LIFE SCIENCES LTD | -- | $46,430.45 | 5,945 | BYZG9R0 |
| 0.07% | ORIC | ORIC PHARMACEUTICALS INC | -- | $46,365.84 | 3,628 | BKVDFF7 |
| 0.07% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $46,017.40 | 3,218 | BN7Q7R7 |
| 0.07% | TRML | TOURMALINE BIO INC | -- | $45,984.00 | 960 | BQ80NC6 |
| 0.07% | ARDX | ARDELYX INC | -- | $45,290.12 | 9,004 | BN89V40 |
| 0.07% | CVAC | CUREVAC NV | -- | $45,088.32 | 8,412 | BN4RD42 |
| 0.07% | PGEN | PRECIGEN INC | -- | $44,532.00 | 11,133 | BKM5C84 |
| 0.07% | GRFS | GRIFOLS SA-ADR | -- | $43,984.70 | 4,558 | B8K7T65 |
| 0.07% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $43,065.23 | 4,381 | BRJZSK0 |
| 0.06% | RLAY | RELAY THERAPEUTICS INC | -- | $41,808.58 | 6,442 | BN2R582 |
| 0.06% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $41,305.86 | 1,737 | BNFWZS4 |
| 0.06% | LENZ | LENZ THERAPEUTICS INC | -- | $40,785.16 | 1,066 | BQV0J03 |
| 0.06% | INVA | INNOVIVA INC | -- | $40,653.58 | 2,354 | BDDXF67 |
| 0.06% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $39,947.38 | 1,177 | BX7RSN3 |
| 0.06% | XNCR | XENCOR INC | -- | $39,347.28 | 2,664 | BGCYWN8 |
| 0.06% | MNMD | MIND MEDICINE MINDMED INC | -- | $38,806.95 | 2,843 | BPQYY97 |
| 0.06% | ORKA | ORUKA THERAPEUTICS INC | -- | $38,472.00 | 1,400 | BKVF0J2 |
| 0.06% | PCRX | PACIRA BIOSCIENCES INC | -- | $38,398.73 | 1,679 | B3X26D8 |
| 0.06% | TNGX | TANGO THERAPEUTICS INC | -- | $37,528.68 | 4,156 | BP2P6L0 |
| 0.06% | SPRY | ARS PHARMACEUTICALS INC | -- | $37,104.60 | 3,692 | BMCR7V2 |
| 0.06% | ANAB | ANAPTYSBIO INC | -- | $36,222.98 | 1,046 | BDRW1L7 |
| 0.05% | PRME | PRIME MEDICINE INC | -- | $35,604.85 | 6,533 | BPBJFM7 |
| 0.05% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $34,344.00 | 2,650 | BJLKVS6 |
| 0.05% | RAPP | RAPPORT THERAPEUTICS INC | -- | $34,061.37 | 1,363 | BR3T9B6 |
| 0.05% | FTRE | FORTREA HOLDINGS INC | -- | $32,026.05 | 3,389 | BRXYZ57 |
| 0.05% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $32,001.60 | 4,520 | BYVQJ96 |
| 0.05% | KURA | KURA ONCOLOGY INC | -- | $31,911.12 | 3,243 | BYZD465 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $31,584.42 | 7,162 | BZ0QMB7 |
| 0.05% | PSNL | PERSONALIS INC | -- | $30,247.69 | 3,313 | BJQ0608 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $30,226.92 | 761 | BL95N25 |
| 0.05% | MESO | MESOBLAST LTD- SPON ADR | -- | $30,111.48 | 1,764 | BQS7491 |
| 0.05% | VIR | VIR BIOTECHNOLOGY INC | -- | $29,998.20 | 5,190 | BK4PZ38 |
| 0.05% | EYPT | EYEPOINT PHARMACEUTICALS INC | -- | $29,947.25 | 2,575 | BMGS7L1 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $29,557.65 | 1,515 | BMGTLY5 |
| 0.04% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $29,473.60 | 13,520 | BF0DMK7 |
| 0.04% | URGN | UROGEN PHARMA LTD | -- | $29,306.55 | 1,729 | BZ7PJQ1 |
| 0.04% | TYRA | TYRA BIOSCIENCES INC | -- | $28,869.50 | 1,991 | BMVNDH9 |
| 0.04% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $28,816.82 | 3,209 | BYTYP72 |
| 0.04% | GERN | GERON CORP | -- | $28,603.20 | 23,836 | 2370381 |
| 0.04% | CRMD | CORMEDIX INC | -- | $28,392.02 | 2,789 | BJ0LT31 |
| 0.04% | NRIX | NURIX THERAPEUTICS INC | -- | $28,103.04 | 2,856 | BMVLGP2 |
| 0.04% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $27,554.40 | 3,827 | BLB0YH0 |
| 0.04% | TERN | TERNS PHARMACEUTICALS INC | -- | $27,500.70 | 3,270 | BMDJ0C9 |
| 0.04% | TBPH | THERAVANCE BIOPHARMA INC | -- | $26,823.06 | 1,881 | BMNDK09 |
| 0.04% | ARVN | ARVINAS INC | -- | $26,113.36 | 2,743 | BDZ30Q0 |
| 0.04% | ERAS | ERASCA INC | -- | $25,647.16 | 10,598 | BNLYBF3 |
| 0.04% | ABSI | ABSCI CORP | -- | $25,309.11 | 5,587 | BN94K69 |
| 0.04% | ATXS | ASTRIA THERAPEUTICS INC | -- | $25,265.82 | 2,109 | BMYRFN8 |
| 0.04% | CSTL | CASTLE BIOSCIENCES INC | -- | $23,999.76 | 1,084 | BKLCWZ3 |
| 0.04% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $23,999.04 | 2,564 | BMZ4LN0 |
| 0.04% | SVRA | SAVARA INC | -- | $23,309.77 | 6,457 | BYXGN81 |
| 0.04% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $23,296.50 | 3,006 | BFYQFJ2 |
| 0.04% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $23,195.40 | 2,308 | BP7KZP7 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $22,668.89 | 2,098 | BLFBZ32 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $22,337.52 | 3,426 | BMC3HS7 |
| 0.03% | SIGA | SIGA TECHNOLOGIES INC | -- | $22,210.80 | 2,676 | 2107437 |
| 0.03% | RGNX | REGENXBIO INC | -- | $22,134.51 | 1,887 | BZ0G875 |
| 0.03% | KROS | KEROS THERAPEUTICS INC | -- | $20,993.94 | 1,518 | BM7V485 |
| 0.03% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $20,969.90 | 1,015 | BKC9SX3 |
| 0.03% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $20,879.10 | 1,881 | BD06CS0 |
| 0.03% | ESPR | ESPERION THERAPEUTICS INC | -- | $20,715.75 | 7,533 | BBNBTD2 |
| 0.03% | OMER | OMEROS CORP | -- | $20,602.91 | 2,542 | B4NB858 |
| 0.03% | INBX | INHIBRX BIOSCIENCES INC | -- | $20,152.25 | 541 | BNSP8K3 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $19,949.12 | 2,011 | B91XRN2 |
| 0.03% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $19,599.36 | 2,784 | BYP80F1 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $19,322.86 | 2,017 | BQ6C357 |
| 0.03% | LXRX | LEXICON PHARMACEUTICALS INC | -- | $19,277.92 | 13,576 | BWFZX59 |
| 0.03% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $18,719.80 | 670 | BQD3J33 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $18,462.85 | 535 | B292NQ7 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $18,404.08 | 11,222 | B4N8MH9 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $17,839.80 | 5,406 | BMCWKZ2 |
| 0.03% | HCM | HUTCHMED CHINA-ADR | -- | $17,547.26 | 1,159 | BYXV9H7 |
| 0.03% | CGEM | CULLINAN THERAPEUTICS INC | -- | $17,335.99 | 2,207 | BM90J52 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $17,170.80 | 1,745 | BKLXFX5 |
| 0.03% | SLDB | SOLID BIOSCIENCES INC | -- | $17,104.92 | 2,909 | BQHN6C7 |
| 0.02% | ALMS | ALUMIS INC | -- | $16,249.31 | 3,619 | BPLQG36 |
| 0.02% | NGNE | NEUROGENE INC | -- | $15,472.99 | 533 | BS2F741 |
| 0.02% | EOLS | EVOLUS INC | -- | $15,462.40 | 2,416 | BDRJH21 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $14,955.01 | 4,031 | BDFKQ07 |
| 0.02% | AMRN | AMARIN CORP PLC -ADR | -- | $14,788.92 | 753 | BN72KB0 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $14,109.59 | 1,727 | BKDQKM6 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $13,431.60 | 3,198 | BMXNGZ6 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $13,160.07 | 2,321 | BP81R42 |
| 0.02% | REPL | REPLIMUNE GROUP INC | -- | $13,122.00 | 2,916 | BDDVW37 |
| 0.02% | ANNX | ANNEXON INC | -- | $12,933.90 | 4,106 | BMVV9R5 |
| 0.02% | EDIT | EDITAS MEDICINE INC | -- | $12,663.43 | 3,359 | BZ8FPH3 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $12,627.51 | 3,297 | BFY7DC4 |
| 0.02% | DSGN | DESIGN THERAPEUTICS INC | -- | $12,214.72 | 2,128 | BMFK3H6 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $12,138.66 | 7,493 | BFMLGR4 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $12,064.74 | 699 | BPBPCG8 |
| 0.02% | LYEL | LYELL IMMUNOPHARMA INC | -- | $11,847.00 | 718 | BTNMG41 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $11,630.89 | 2,207 | B12W3P6 |
| 0.02% | ALEC | ALECTOR INC | -- | $11,497.28 | 3,782 | BJ4LDC4 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $11,401.00 | 1,754 | BL5B6Z1 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $10,877.90 | 3,751 | BZC0D70 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $10,714.08 | 1,616 | BSMLR16 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $10,468.23 | 6,051 | BN4JN37 |
| 0.02% | VYGR | VOYAGER THERAPEUTICS INC | -- | $10,256.40 | 2,072 | BY7RB53 |
| 0.02% | TKNO | ALPHA TEKNOVA INC | -- | $10,254.87 | 1,999 | BP7L561 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $10,195.47 | 8,289 | BFZNYB7 |
| 0.02% | HUMA | HUMACYTE INC | -- | $10,177.24 | 5,917 | BMYTJP4 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $9,072.90 | 2,965 | BLN9Z50 |
| 0.01% | CDXS | CODEXIS INC | -- | $8,935.80 | 3,372 | B5LL2C2 |
| 0.01% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $8,785.98 | 798 | B9L5200 |
| 0.01% | RNAC | CARTESIAN THERAPEUTICS INC | -- | $8,748.71 | 971 | BQB9HM8 |
| 0.01% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $8,678.67 | 6,069 | B3MZ6K5 |
| 0.01% | FHTX | FOGHORN THERAPEUTICS INC | -- | $8,426.88 | 2,112 | BMF7DT9 |
| 0.01% | TRDA | ENTRADA THERAPEUTICS INC | -- | $8,341.27 | 1,421 | BP81RK8 |
| 0.01% | PYXS | PYXIS ONCOLOGY INC | -- | $7,785.12 | 2,317 | BLBR8D5 |
| 0.01% | OABI | OMNIAB INC | -- | $7,609.44 | 4,584 | BN13S71 |
| 0.01% | APLT | APPLIED THERAPEUTICS INC | -- | $6,886.40 | 5,380 | BJL38Z1 |
| 0.01% | MXCT | MAXCYTE INC | -- | $6,412.63 | 3,983 | BKMQF66 |
| 0.01% | FATE | FATE THERAPEUTICS INC | -- | $6,334.23 | 4,309 | BCZS820 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $6,301.83 | 2,659 | BKX9NQ0 |
| 0.01% | NKTX | NKARTA INC | -- | $6,101.90 | 2,653 | BK80YJ8 |
| 0.01% | PEPG | PEPGEN INC | -- | $5,990.25 | 1,225 | BMTX3D7 |
| 0.01% | ARTV | ARTIVA BIOTHERAPEUTICS INC | -- | $5,481.12 | 912 | BMF1LJ7 |
| 0.01% | TVGN | TEVOGEN BIO HOLDINGS INC | -- | $5,156.06 | 7,349 | BPG5P75 |
| 0.01% | CLYM | CLIMB BIO INC | -- | $4,884.83 | 2,531 | BMW5LX6 |
| 0.01% | TCRX | TSCAN THERAPEUTICS INC | -- | $4,860.80 | 1,960 | BNLYBJ7 |
| 0.01% | MGNX | MACROGENICS INC | -- | $3,897.30 | 2,362 | BFDV8K0 |
| 0.01% | PLRX | PLIANT THERAPEUTICS INC | -- | $3,601.58 | 2,294 | BMDWW66 |
| 0.01% | BMEA | BIOMEA FUSION INC | -- | $3,356.73 | 2,223 | BNKF6N0 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $3,198.67 | 3,167 | BF12XC2 |
| -- | ACRV | ACRIVON THERAPEUTICS INC | -- | $2,126.75 | 1,175 | BP2TPK4 |
| -- | MRSN | MERSANA THERAPEUTICS INC | -- | $1,847.56 | 187 | BVPKH99 |
| -- | QTTB | Q32 BIO INC | -- | $1,445.52 | 456 | BS2FKQ4 |
| -- | OKUR | ONKURE THERAPEUTICS INC-A | -- | $1,331.62 | 479 | BT7KGT6 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| 29.03% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 19,065,937 | -- | 3,675 | -- |
| 26.63% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 17,488,782 | -- | 3,371 | -- |
| 23.44% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 15,392,826 | -- | 2,967 | -- |
| 21.68% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 14,241,087 | -- | 2,745 | -- |
| 19.62% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 12,887,017 | -- | 2,484 | -- |
| 15.16% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 9,955,791 | -- | 1,919 | -- |
| -- | -- | UNITED STATES OF AMERICA BILL ZERO CPN 20/NOV/2025 | -- | $4,982,832.40 | 5,000,000 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $18,236,018.52 | 18,236,019 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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