BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 10/31/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 20.05% | 41.93% | 51.59% | 42.58% | 20.67% | 9.55% | 2.60% | 0.91% | 15.79% | 04/07/2010 |
| BIB Market Price | 20.06% | 42.12% | 51.73% | 42.51% | 20.92% | 9.51% | 2.55% | 0.91% | 15.79% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/08/2025- NAV $80.64
- NAV Change $-0.50
- Market Price $80.60
- Market Price Change $-0.56
- Trading Volume (M) 10,429
- 30-Day Median Bid Ask Spread 0.26%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/08/2025- NAV $80.64
- NAV Change $-0.50
- Market Price $80.60
- Market Price Change $-0.56
- Trading Volume (M) 10,429
- 30-Day Median Bid Ask Spread 0.26%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 12/08/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.18% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $4,424,820.40 | 10,010 | 2931034 |
| 5.11% | AMGN | AMGEN INC | -- | $4,370,012.92 | 13,604 | 2023607 |
| 4.91% | GILD | GILEAD SCIENCES INC | -- | $4,199,233.50 | 34,650 | 2369174 |
| 4.02% | REGN | REGENERON PHARMACEUTICALS | -- | $3,436,831.62 | 4,887 | 2730190 |
| 3.09% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,644,192.98 | 6,149 | B00FWN1 |
| 2.62% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $2,235,721.04 | 24,493 | 2989044 |
| 2.30% | INSM | INSMED INC | -- | $1,965,303.45 | 9,999 | 2614487 |
| 1.52% | ARGX | ARGENX SE - ADR | -- | $1,303,399.72 | 1,447 | BDVLM39 |
| 1.46% | BIIB | BIOGEN INC | -- | $1,251,351.40 | 6,935 | 2455965 |
| 1.20% | UTHR | UNITED THERAPEUTICS CORP | -- | $1,025,671.89 | 2,139 | 2430412 |
| 1.08% | ILMN | ILLUMINA INC | -- | $925,107.50 | 7,270 | 2613990 |
| 1.04% | INCY | INCYTE CORP | -- | $893,121.20 | 9,236 | 2471950 |
| 0.92% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $790,685.49 | 20,447 | BMVP7Y0 |
| 0.85% | MEDP | MEDPACE HOLDINGS INC | -- | $729,846.93 | 1,329 | BDCBC61 |
| 0.85% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $726,903.10 | 4,690 | 2623911 |
| 0.83% | RVMD | REVOLUTION MEDICINES INC | -- | $707,890.52 | 8,842 | BL71K91 |
| 0.79% | ROIV | ROIVANT SCIENCES LTD | -- | $677,977.00 | 32,300 | BMW4NZ9 |
| 0.79% | BBIO | BRIDGEBIO PHARMA INC | -- | $671,203.84 | 9,041 | BK1KWG8 |
| 0.77% | SMMT | SUMMIT THERAPEUTICS INC | -- | $654,408.00 | 35,136 | BMTVQS7 |
| 0.72% | SNY | SANOFI-ADR | -- | $614,848.92 | 12,693 | 2964557 |
| 0.72% | TEM | TEMPUS AI INC | -- | $614,625.12 | 7,978 | BSLSJJ0 |
| 0.72% | GH | GUARDANT HEALTH INC | -- | $614,498.83 | 5,899 | BFXC911 |
| 0.72% | IONS | IONIS PHARMACEUTICALS INC | -- | $614,422.38 | 7,538 | BDJ0LS6 |
| 0.72% | VTRS | VIATRIS INC | -- | $611,546.96 | 55,144 | BMWS3X9 |
| 0.70% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $600,978.49 | 1,057 | BD59BS7 |
| 0.70% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $594,641.52 | 2,871 | BV9G6B8 |
| 0.63% | EXEL | EXELIXIS INC | -- | $536,908.44 | 12,732 | 2576941 |
| 0.61% | ONC | BEONE MEDICINES LTD-ADR | -- | $519,119.10 | 1,590 | BYYWPW6 |
| 0.60% | MRNA | MODERNA INC | -- | $514,731.91 | 18,403 | BGSXTS3 |
| 0.57% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $484,519.92 | 2,868 | B4Q5ZN4 |
| 0.57% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $483,964.00 | 9,080 | 2437071 |
| 0.54% | BNTX | BIONTECH SE-ADR | -- | $462,858.24 | 4,758 | BK6H543 |
| 0.52% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $448,644.00 | 6,540 | BYQBFJ8 |
| 0.51% | RNA | AVIDITY BIOSCIENCES INC | -- | $433,617.10 | 6,085 | BMWHPY1 |
| 0.42% | CYTK | CYTOKINETICS INC | -- | $362,975.80 | 5,660 | BBBSBJ5 |
| 0.41% | AXSM | AXSOME THERAPEUTICS INC | -- | $348,389.16 | 2,361 | BYZR4X4 |
| 0.41% | HALO | HALOZYME THERAPEUTICS INC | -- | $347,852.16 | 5,532 | 2975098 |
| 0.40% | MRUS | MERUS NV | -- | $344,357.79 | 3,577 | BZBY005 |
| 0.40% | NUVL | NUVALENT INC-A | -- | $340,221.98 | 3,154 | BMVBZD3 |
| 0.39% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $330,475.56 | 3,142 | BF2YWG4 |
| 0.37% | KRYS | KRYSTAL BIOTECH INC | -- | $320,180.40 | 1,368 | BD6JX35 |
| 0.37% | KYMR | KYMERA THERAPEUTICS INC | -- | $318,922.60 | 3,382 | BMPRZV5 |
| 0.34% | PTCT | PTC THERAPEUTICS INC | -- | $289,027.78 | 3,758 | B17VCN9 |
| 0.33% | PCVX | VAXCYTE INC | -- | $283,591.38 | 6,141 | BKPVGH6 |
| 0.32% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $269,896.08 | 996 | BQ721R4 |
| 0.31% | COGT | COGENT BIOSCIENCES INC | -- | $266,302.40 | 6,608 | BLR6XK8 |
| 0.31% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $265,515.50 | 2,942 | BDCBCD8 |
| 0.29% | CRSP | CRISPR THERAPEUTICS AG | -- | $246,303.84 | 4,294 | BDHF4K6 |
| 0.27% | ALKS | ALKERMES PLC | -- | $229,633.28 | 7,808 | B3P6D26 |
| 0.26% | ADMA | ADMA BIOLOGICS INC | -- | $218,854.93 | 11,287 | B9NSBM2 |
| 0.25% | INDV | INDIVIOR PLC | -- | $216,013.20 | 5,902 | BP0BQQ5 |
| 0.25% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $213,544.80 | 7,980 | 2713317 |
| 0.25% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $211,119.60 | 4,454 | BDD19F8 |
| 0.24% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $205,797.00 | 4,548 | BFZQ0L8 |
| 0.23% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $197,273.62 | 2,819 | BQS9486 |
| 0.23% | ACLX | ARCELLX INC | -- | $194,311.84 | 2,623 | BPCJ1Q2 |
| 0.22% | IMVT | IMMUNOVANT INC | -- | $191,013.48 | 8,244 | BJRFSB7 |
| 0.22% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $190,404.50 | 5,326 | BP8JSP4 |
| 0.21% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $176,328.85 | 14,855 | BFNF1D6 |
| 0.21% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $175,878.04 | 5,668 | BKX9VD3 |
| 0.20% | LGND | LIGAND PHARMACEUTICALS | -- | $171,189.09 | 927 | 2501578 |
| 0.20% | GRAL | GRAIL INC | -- | $170,258.80 | 1,706 | BSLSSX7 |
| 0.19% | TERN | TERNS PHARMACEUTICALS INC | -- | $166,270.59 | 4,133 | BMDJ0C9 |
| 0.19% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $166,175.55 | 4,559 | BJ62Z18 |
| 0.19% | APGE | APOGEE THERAPEUTICS INC | -- | $166,028.38 | 2,182 | BM9HHL5 |
| 0.19% | VCYT | VERACYTE INC | -- | $165,063.56 | 3,721 | BFTWZY0 |
| 0.19% | TARS | TARSUS PHARMACEUTICALS INC | -- | $164,131.08 | 1,996 | BMH5RL1 |
| 0.19% | XENE | XENON PHARMACEUTICALS INC | -- | $162,400.91 | 3,647 | BRJ3GY4 |
| 0.19% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $161,330.40 | 2,376 | BJDX8Y8 |
| 0.18% | CGON | CG ONCOLOGY INC | -- | $154,379.60 | 3,607 | BRBCSP4 |
| 0.18% | IRON | DISC MEDICINE INC | -- | $151,550.32 | 1,643 | BMGJZJ8 |
| 0.17% | DYN | DYNE THERAPEUTICS INC | -- | $149,361.60 | 6,728 | BN15WD1 |
| 0.17% | IDYA | IDEAYA BIOSCIENCES INC | -- | $146,448.96 | 4,144 | BK0VHF6 |
| 0.17% | TVTX | TRAVERE THERAPEUTICS INC | -- | $144,532.35 | 4,215 | BLFGJD5 |
| 0.17% | FOLD | AMICUS THERAPEUTICS INC | -- | $143,613.00 | 14,580 | B19FQ48 |
| 0.17% | APLS | APELLIS PHARMACEUTICALS INC | -- | $142,121.46 | 5,974 | BYTQ6X1 |
| 0.16% | WVE | WAVE LIFE SCIENCES LTD | -- | $139,400.04 | 7,527 | BYZG9R0 |
| 0.16% | DNLI | DENALI THERAPEUTICS INC | -- | $136,195.73 | 6,917 | BD2B4V0 |
| 0.16% | VERA | VERA THERAPEUTICS INC | -- | $135,900.54 | 3,018 | BL55460 |
| 0.16% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $133,782.50 | 4,535 | BLB0YQ9 |
| 0.16% | OCUL | OCULAR THERAPEUTIX INC | -- | $132,569.19 | 8,229 | BNZB1X8 |
| 0.15% | BEAM | BEAM THERAPEUTICS INC | -- | $129,700.60 | 4,786 | BK6L288 |
| 0.15% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $125,115.48 | 2,653 | B72ZBG4 |
| 0.14% | MLYS | MINERALYS THERAPEUTICS INC | -- | $119,795.20 | 3,136 | BP9N0G0 |
| 0.14% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $117,399.48 | 4,983 | BKY5JZ8 |
| 0.13% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $107,669.90 | 7,202 | BJ5FZ74 |
| 0.12% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $105,862.40 | 2,720 | BKSGZN7 |
| 0.12% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $104,009.84 | 3,982 | BMX9K07 |
| 0.12% | SRPT | SAREPTA THERAPEUTICS INC | -- | $101,058.78 | 4,623 | B8DPDT7 |
| 0.12% | IBRX | IMMUNITYBIO INC | -- | $101,042.34 | 44,709 | BNSP0B8 |
| 0.12% | SYRE | SPYRE THERAPEUTICS INC | -- | $98,937.91 | 2,857 | BQBBDY8 |
| 0.11% | AVDL | AVADEL PHARMACEUTICALS | -- | $97,901.44 | 4,592 | BDGMC59 |
| 0.11% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $97,623.68 | 6,226 | BFWLC09 |
| 0.11% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $97,421.84 | 20,212 | BM9FJ13 |
| 0.11% | TXG | 10X GENOMICS INC-CLASS A | -- | $94,547.64 | 5,412 | BKS3RS7 |
| 0.11% | ZYME | ZYMEWORKS INC | -- | $93,887.55 | 3,555 | BPCQZY9 |
| 0.11% | TWST | TWIST BIOSCIENCE CORP | -- | $91,988.10 | 2,855 | BGKG6G7 |
| 0.11% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $90,823.08 | 3,246 | BMZ4LN0 |
| 0.10% | VCEL | VERICEL CORP | -- | $88,997.80 | 2,386 | BSBMN89 |
| 0.10% | STOK | STOKE THERAPEUTICS INC | -- | $85,536.00 | 2,592 | BJQ05Z6 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $85,426.80 | 2,056 | BRXB0C0 |
| 0.10% | ANIP | ANI PHARMACEUTICALS INC | -- | $83,454.84 | 1,026 | BCDWBX6 |
| 0.10% | HROW | HARROW INC | -- | $83,072.50 | 1,750 | BHNDW86 |
| 0.10% | MNKD | MANNKIND CORP | -- | $81,708.19 | 14,513 | BF081J4 |
| 0.10% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $81,418.50 | 4,075 | BN7Q7R7 |
| 0.09% | ALVO | ALVOTECH SA | -- | $80,681.80 | 14,804 | BPNTJ34 |
| 0.09% | NRIX | NURIX THERAPEUTICS INC | -- | $77,592.58 | 3,614 | BMVLGP2 |
| 0.09% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $76,461.00 | 9,930 | 2100362 |
| 0.09% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $75,129.12 | 2,754 | BCBVTX1 |
| 0.09% | TRVI | TREVI THERAPEUTICS INC | -- | $74,764.80 | 5,760 | BJH9ZN0 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $72,180.34 | 1,894 | BLCD809 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $71,385.90 | 1,490 | BX7RSN3 |
| 0.08% | TSHA | TAYSHA GENE THERAPIES INC | -- | $70,315.90 | 12,902 | BNC1BX1 |
| 0.08% | ARDX | ARDELYX INC | -- | $67,020.24 | 11,398 | BN89V40 |
| 0.08% | INBX | INHIBRX BIOSCIENCES INC | -- | $64,147.86 | 686 | BNSP8K3 |
| 0.07% | NVCR | NOVOCURE LTD | -- | $63,773.28 | 5,288 | BYSS4X4 |
| 0.07% | FTRE | FORTREA HOLDINGS INC | -- | $63,465.32 | 4,294 | BRXYZ57 |
| 0.07% | GMAB | GENMAB A/S -SP ADR | -- | $63,337.02 | 1,983 | BBC9WC7 |
| 0.07% | INVA | INNOVIVA INC | -- | $62,601.00 | 2,981 | BDDXF67 |
| 0.07% | RLAY | RELAY THERAPEUTICS INC | -- | $62,215.02 | 8,154 | BN2R582 |
| 0.07% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $60,839.62 | 5,546 | BRJZSK0 |
| 0.07% | XNCR | XENCOR INC | -- | $59,652.32 | 3,374 | BGCYWN8 |
| 0.07% | ANAB | ANAPTYSBIO INC | -- | $58,975.75 | 1,325 | BDRW1L7 |
| 0.07% | EYPT | EYEPOINT PHARMACEUTICALS INC | -- | $58,093.20 | 3,260 | BMGS7L1 |
| 0.07% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $57,605.38 | 4,214 | BPCK358 |
| 0.07% | TYRA | TYRA BIOSCIENCES INC | -- | $57,478.80 | 2,521 | BMVNDH9 |
| 0.07% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $57,476.52 | 2,801 | BMFD115 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $57,195.99 | 2,199 | BNFWZS4 |
| 0.07% | SANA | SANA BIOTECHNOLOGY INC | -- | $56,652.68 | 12,236 | BMFJJ97 |
| 0.07% | QURE | UNIQURE NV | -- | $56,493.15 | 2,595 | BJFSR88 |
| 0.07% | ORKA | ORUKA THERAPEUTICS INC | -- | $55,689.10 | 1,771 | BKVF0J2 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $53,389.62 | 7,638 | BLR7H87 |
| 0.06% | SVRA | SAVARA INC | -- | $52,898.72 | 8,176 | BYXGN81 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $52,235.10 | 1,371 | BKLCWZ3 |
| 0.06% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $52,139.85 | 2,921 | BP7KZP7 |
| 0.06% | RAPP | RAPPORT THERAPEUTICS INC | -- | $52,086.32 | 1,727 | BR3T9B6 |
| 0.06% | NVAX | NOVAVAX INC | -- | $52,083.96 | 7,682 | BJDQXG4 |
| 0.06% | PGEN | PRECIGEN INC | -- | $52,003.17 | 14,093 | BKM5C84 |
| 0.06% | PCRX | PACIRA BIOSCIENCES INC | -- | $51,892.50 | 2,125 | B3X26D8 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $51,814.60 | 5,770 | B8K7T65 |
| 0.06% | ALMS | ALUMIS INC | -- | $51,135.12 | 4,582 | BPLQG36 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $50,741.06 | 14,134 | BL53SR3 |
| 0.06% | TNGX | TANGO THERAPEUTICS INC | -- | $50,524.80 | 5,263 | BP2P6L0 |
| 0.06% | URGN | UROGEN PHARMA LTD | -- | $50,522.12 | 2,189 | BZ7PJQ1 |
| 0.06% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $49,989.50 | 3,355 | BJLKVS6 |
| 0.06% | ORIC | ORIC PHARMACEUTICALS INC | -- | $48,318.36 | 4,593 | BKVDFF7 |
| 0.06% | NTLA | INTELLIA THERAPEUTICS INC | -- | $47,926.88 | 5,077 | BYZM6C2 |
| 0.06% | AVBP | ARRIVENT BIOPHARMA INC | -- | $47,911.64 | 1,918 | BMGTLY5 |
| 0.06% | KURA | KURA ONCOLOGY INC | -- | $47,782.20 | 4,105 | BYZD465 |
| 0.06% | JANX | JANUX THERAPEUTICS INC | -- | $47,120.36 | 2,842 | BMFX8Y7 |
| 0.05% | MNMD | MIND MEDICINE MINDMED INC | -- | $46,878.00 | 3,606 | BPQYY97 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $46,740.00 | 4,674 | BMCR7V2 |
| 0.05% | ARVN | ARVINAS INC | -- | $46,260.36 | 3,473 | BDZ30Q0 |
| 0.05% | ERAS | ERASCA INC | -- | $44,812.78 | 13,417 | BNLYBF3 |
| 0.05% | VIR | VIR BIOTECHNOLOGY INC | -- | $43,230.60 | 6,570 | BK4PZ38 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $43,161.84 | 2,382 | BMNDK09 |
| 0.05% | ZLAB | ZAI LAB LTD-ADR | -- | $43,091.10 | 2,262 | BD9GVY0 |
| 0.05% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $41,852.16 | 4,844 | BLB0YH0 |
| 0.05% | PSNL | PERSONALIS INC | -- | $41,185.08 | 4,194 | BJQ0608 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $40,982.84 | 9,067 | BZ0QMB7 |
| 0.05% | KROS | KEROS THERAPEUTICS INC | -- | $40,934.40 | 1,920 | BM7V485 |
| 0.05% | MESO | MESOBLAST LTD- SPON ADR | -- | $40,439.63 | 2,233 | BQS7491 |
| 0.05% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $40,143.66 | 2,381 | BD06CS0 |
| 0.05% | CRMD | CORMEDIX INC | -- | $39,759.06 | 3,531 | BJ0LT31 |
| 0.05% | REPL | REPLIMUNE GROUP INC | -- | $39,615.16 | 3,692 | BDDVW37 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $39,537.96 | 17,116 | BF0DMK7 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $38,597.04 | 963 | BL95N25 |
| 0.04% | GERN | GERON CORP | -- | $38,324.79 | 30,177 | 2370381 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $37,873.02 | 5,721 | BYVQJ96 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $37,289.67 | 9,537 | BBNBTD2 |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $36,846.60 | 849 | BQD3J33 |
| 0.04% | OMER | OMEROS CORP | -- | $36,696.60 | 3,219 | B4NB858 |
| 0.04% | LENZ | LENZ THERAPEUTICS INC | -- | $36,031.79 | 1,349 | BQV0J03 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $34,820.91 | 8,271 | BPBJFM7 |
| 0.04% | CGEM | CULLINAN THERAPEUTICS INC | -- | $34,744.92 | 2,793 | BM90J52 |
| 0.04% | ATXS | ASTRIA THERAPEUTICS INC | -- | $34,710.00 | 2,670 | BMYRFN8 |
| 0.04% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $32,960.24 | 14,207 | B4N8MH9 |
| 0.04% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $32,951.30 | 3,805 | BFYQFJ2 |
| 0.04% | RGNX | REGENXBIO INC | -- | $31,749.52 | 2,398 | BZ0G875 |
| 0.04% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $30,174.00 | 3,525 | BYP80F1 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $27,329.40 | 4,338 | BMC3HS7 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $27,318.58 | 2,546 | B91XRN2 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $26,656.54 | 7,682 | B3MZ6K5 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $26,552.98 | 2,693 | BMFK3H6 |
| 0.03% | LYEL | LYELL IMMUNOPHARMA INC | -- | $25,807.60 | 910 | BTNMG41 |
| 0.03% | ANNX | ANNEXON INC | -- | $25,233.12 | 5,192 | BMVV9R5 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $24,706.84 | 6,844 | BMCWKZ2 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $24,475.72 | 2,209 | BKLXFX5 |
| 0.03% | ABSI | ABSCI CORP | -- | $24,401.85 | 7,073 | BN94K69 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $24,135.30 | 2,554 | BQ6C357 |
| 0.03% | LXRX | LEXICON PHARMACEUTICALS INC | -- | $23,892.71 | 17,189 | BWFZX59 |
| 0.03% | ALT | ALTIMMUNE INC | -- | $23,421.75 | 4,175 | BFY7DC4 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $23,319.68 | 2,656 | BLFBZ32 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $21,350.22 | 678 | B292NQ7 |
| 0.02% | EOLS | EVOLUS INC | -- | $21,328.20 | 3,060 | BDRJH21 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $21,035.64 | 3,684 | BQHN6C7 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $20,830.05 | 3,387 | 2107437 |
| 0.02% | HCM | HUTCHMED CHINA-ADR | -- | $20,610.72 | 1,468 | BYXV9H7 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $19,872.00 | 1,800 | BP81RK8 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $18,803.20 | 2,938 | BP81R42 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $17,864.00 | 5,104 | BDFKQ07 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $17,708.85 | 885 | BPBPCG8 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $17,629.08 | 4,062 | BYTYP72 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $17,155.16 | 2,794 | B12W3P6 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $16,920.42 | 2,046 | BSMLR16 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $16,775.40 | 7,660 | BN4JN37 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $16,161.60 | 2,184 | BKDQKM6 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $15,463.36 | 4,048 | BMXNGZ6 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $15,443.85 | 2,235 | BL5B6Z1 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $15,217.75 | 10,495 | BFZNYB7 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $15,082.74 | 9,486 | BFMLGR4 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $14,350.16 | 1,012 | B9L5200 |
| 0.02% | AMRN | AMARIN CORP PLC -ADR | -- | $14,218.76 | 953 | BN72KB0 |
| 0.02% | NGNE | NEUROGENE INC | -- | $13,918.84 | 676 | BS2F741 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $13,118.82 | 4,719 | BZC0D70 |
| 0.01% | PYXS | PYXIS ONCOLOGY INC | -- | $12,259.94 | 2,933 | BLBR8D5 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $12,012.80 | 3,754 | BLN9Z50 |
| 0.01% | FHTX | FOGHORN THERAPEUTICS INC | -- | $11,899.30 | 2,674 | BMF7DT9 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $11,591.98 | 2,531 | BP7L561 |
| 0.01% | OABI | OMNIAB INC | -- | $11,547.97 | 5,803 | BN13S71 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $11,331.36 | 2,623 | BY7RB53 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $10,292.26 | 4,253 | BZ8FPH3 |
| 0.01% | HUMA | HUMACYTE INC | -- | $9,663.39 | 7,491 | BMYTJP4 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $9,565.80 | 1,284 | BKC9SX3 |
| 0.01% | PEPG | PEPGEN INC | -- | $8,675.68 | 1,552 | BMTX3D7 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $8,552.18 | 3,367 | BKX9NQ0 |
| 0.01% | RNAC | CARTESIAN THERAPEUTICS INC | -- | $8,272.32 | 1,231 | BQB9HM8 |
| 0.01% | CDXS | CODEXIS INC | -- | $8,196.48 | 4,269 | B5LL2C2 |
| 0.01% | MXCT | MAXCYTE INC | -- | $7,816.65 | 5,043 | BKMQF66 |
| 0.01% | MRSN | MERSANA THERAPEUTICS INC | -- | $6,589.12 | 236 | BVPKH99 |
| 0.01% | NKTX | NKARTA INC | -- | $6,148.80 | 3,360 | BK80YJ8 |
| 0.01% | ALEC | ALECTOR INC | -- | $5,841.36 | 4,788 | BJ4LDC4 |
| 0.01% | FATE | FATE THERAPEUTICS INC | -- | $5,836.85 | 5,455 | BCZS820 |
| 0.01% | CLYM | CLIMB BIO INC | -- | $5,802.86 | 3,206 | BMW5LX6 |
| -- | TVGN | TEVOGEN BIO HOLDINGS INC | -- | $4,055.61 | 9,304 | BPG5P75 |
| -- | MGNX | MACROGENICS INC | -- | $3,976.70 | 2,990 | BFDV8K0 |
| -- | BMEA | BIOMEA FUSION INC | -- | $3,800.25 | 2,815 | BNKF6N0 |
| -- | ACRV | ACRIVON THERAPEUTICS INC | -- | $3,749.76 | 1,488 | BP2TPK4 |
| -- | PLRX | PLIANT THERAPEUTICS INC | -- | $3,717.12 | 2,904 | BMDWW66 |
| -- | ARTV | ARTIVA BIOTHERAPEUTICS INC | -- | $3,560.48 | 1,156 | BMF1LJ7 |
| -- | -- | SUTRO BIOPHARMA INC COMMON STOCK USD 0.001 | -- | $3,398.00 | 400 | -- |
| -- | TCRX | TSCAN THERAPEUTICS INC | -- | $2,481.00 | 2,481 | BNLYBJ7 |
| -- | OKUR | ONKURE THERAPEUTICS INC-A | -- | $2,079.36 | 608 | BT7KGT6 |
| -- | QTTB | Q32 BIO INC | -- | $1,992.96 | 576 | BS2FKQ4 |
| -- | APLT | APPLIED THERAPEUTICS INC | -- | $1,498.42 | 6,811 | BJL38Z1 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 35.76% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 30,570,562 | -- | 5,343 | -- |
| 33.52% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 28,653,823 | -- | 5,008 | -- |
| 26.08% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 22,297,114 | -- | 3,897 | -- |
| 16.63% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,212,479 | -- | 2,484 | -- |
| 15.39% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 13,153,981 | -- | 2,299 | -- |
| 4.24% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,621,779 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $26,645,154.19 | 26,645,154 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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