BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 10/31/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 20.05% | 41.93% | 51.59% | 42.58% | 20.67% | 9.55% | 2.60% | 0.91% | 15.79% | 04/07/2010 |
| BIB Market Price | 20.06% | 42.12% | 51.73% | 42.51% | 20.92% | 9.51% | 2.55% | 0.91% | 15.79% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 11/21/2025- NAV $77.63
- NAV Change $+2.67
- Market Price $77.61
- Market Price Change $+2.63
- Trading Volume (M) 20,200
- 30-Day Median Bid Ask Spread 0.29%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 11/21/2025- NAV $77.63
- NAV Change $+2.67
- Market Price $77.61
- Market Price Change $+2.63
- Trading Volume (M) 20,200
- 30-Day Median Bid Ask Spread 0.29%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 11/21/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.32% | AMGN | AMGEN INC | -- | $4,295,534.04 | 12,726 | 2023607 |
| 5.08% | GILD | GILEAD SCIENCES INC | -- | $4,104,529.04 | 32,411 | 2369174 |
| 4.95% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $3,996,180.64 | 9,364 | 2931034 |
| 4.28% | REGN | REGENERON PHARMACEUTICALS | -- | $3,455,218.90 | 4,571 | 2730190 |
| 3.11% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,510,057.76 | 5,752 | B00FWN1 |
| 2.58% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $2,085,083.00 | 22,913 | 2989044 |
| 2.30% | INSM | INSMED INC | -- | $1,858,803.52 | 9,352 | 2614487 |
| 1.54% | ARGX | ARGENX SE - ADR | -- | $1,245,136.60 | 1,355 | BDVLM39 |
| 1.41% | BIIB | BIOGEN INC | -- | $1,137,171.10 | 6,487 | 2455965 |
| 1.18% | UTHR | UNITED THERAPEUTICS CORP | -- | $950,114.82 | 2,001 | 2430412 |
| 1.09% | INCY | INCYTE CORP | -- | $881,798.40 | 8,640 | 2471950 |
| 1.04% | ILMN | ILLUMINA INC | -- | $842,303.85 | 6,801 | 2613990 |
| 0.92% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $744,422.84 | 19,127 | BMVP7Y0 |
| 0.91% | MEDP | MEDPACE HOLDINGS INC | -- | $735,632.26 | 1,243 | BDCBC61 |
| 0.77% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $622,350.04 | 4,388 | 2623911 |
| 0.76% | ROIV | ROIVANT SCIENCES LTD | -- | $610,947.30 | 30,215 | BMW4NZ9 |
| 0.73% | SNY | SANOFI-ADR | -- | $589,207.36 | 11,872 | 2964557 |
| 0.73% | RVMD | REVOLUTION MEDICINES INC | -- | $586,165.77 | 8,271 | BL71K91 |
| 0.72% | GH | GUARDANT HEALTH INC | -- | $581,707.56 | 5,518 | BFXC911 |
| 0.71% | BBIO | BRIDGEBIO PHARMA INC | -- | $576,074.38 | 8,458 | BK1KWG8 |
| 0.70% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $566,639.08 | 2,692 | BV9G6B8 |
| 0.67% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $540,288.56 | 986 | BD59BS7 |
| 0.66% | IONS | IONIS PHARMACEUTICALS INC | -- | $536,586.68 | 7,052 | BDJ0LS6 |
| 0.66% | VTRS | VIATRIS INC | -- | $533,388.90 | 51,585 | BMWS3X9 |
| 0.66% | SMMT | SUMMIT THERAPEUTICS INC | -- | $532,132.92 | 32,868 | BMTVQS7 |
| 0.65% | TEM | TEMPUS AI INC | -- | $524,644.56 | 7,464 | BSLSJJ0 |
| 0.64% | ONC | BEONE MEDICINES LTD-ADR | -- | $517,059.64 | 1,487 | BYYWPW6 |
| 0.63% | EXEL | EXELIXIS INC | -- | $506,336.61 | 11,911 | 2576941 |
| 0.59% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $474,880.12 | 2,684 | B4Q5ZN4 |
| 0.58% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $464,646.24 | 8,496 | 2437071 |
| 0.53% | BNTX | BIONTECH SE-ADR | -- | $425,471.09 | 4,451 | BK6H543 |
| 0.51% | MRNA | MODERNA INC | -- | $408,339.80 | 17,215 | BGSXTS3 |
| 0.50% | RNA | AVIDITY BIOSCIENCES INC | -- | $401,627.52 | 5,692 | BMWHPY1 |
| 0.45% | HALO | HALOZYME THERAPEUTICS INC | -- | $364,009.50 | 5,175 | 2975098 |
| 0.43% | CYTK | CYTOKINETICS INC | -- | $346,439.36 | 5,294 | BBBSBJ5 |
| 0.41% | AXSM | AXSOME THERAPEUTICS INC | -- | $329,963.52 | 2,208 | BYZR4X4 |
| 0.40% | MRUS | MERUS NV | -- | $320,412.96 | 3,346 | BZBY005 |
| 0.39% | NUVL | NUVALENT INC-A | -- | $312,346.00 | 2,950 | BMVBZD3 |
| 0.37% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $299,013.86 | 2,939 | BF2YWG4 |
| 0.34% | PTCT | PTC THERAPEUTICS INC | -- | $275,822.05 | 3,515 | B17VCN9 |
| 0.34% | PCVX | VAXCYTE INC | -- | $274,448.32 | 5,744 | BKPVGH6 |
| 0.34% | KRYS | KRYSTAL BIOTECH INC | -- | $271,597.62 | 1,281 | BD6JX35 |
| 0.31% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $247,432.65 | 6,117 | BYQBFJ8 |
| 0.29% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $235,106.20 | 2,753 | BDCBCD8 |
| 0.28% | COGT | COGENT BIOSCIENCES INC | -- | $227,213.56 | 6,181 | BLR6XK8 |
| 0.27% | ACLX | ARCELLX INC | -- | $221,326.26 | 2,454 | BPCJ1Q2 |
| 0.26% | ALKS | ALKERMES PLC | -- | $208,967.44 | 7,304 | B3P6D26 |
| 0.26% | KYMR | KYMERA THERAPEUTICS INC | -- | $208,884.52 | 3,163 | BMPRZV5 |
| 0.25% | CRSP | CRISPR THERAPEUTICS AG | -- | $202,125.52 | 4,024 | BDHF4K6 |
| 0.24% | AKRO | AKERO THERAPEUTICS INC | -- | $192,203.09 | 3,539 | BK7Y2V9 |
| 0.24% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $190,699.41 | 4,983 | BP8JSP4 |
| 0.22% | ADMA | ADMA BIOLOGICS INC | -- | $181,386.44 | 10,558 | B9NSBM2 |
| 0.22% | INDV | INDIVIOR PLC | -- | $180,812.75 | 5,521 | BP0BQQ5 |
| 0.22% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $178,597.62 | 4,167 | BDD19F8 |
| 0.22% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $175,875.40 | 7,465 | 2713317 |
| 0.22% | IMVT | IMMUNOVANT INC | -- | $174,236.67 | 7,713 | BJRFSB7 |
| 0.21% | LGND | LIGAND PHARMACEUTICALS | -- | $172,732.41 | 867 | 2501578 |
| 0.21% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $171,013.13 | 4,253 | BFZQ0L8 |
| 0.21% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $166,069.15 | 13,897 | BFNF1D6 |
| 0.20% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $158,083.80 | 931 | BQ721R4 |
| 0.20% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $157,766.31 | 2,223 | BJDX8Y8 |
| 0.19% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $156,444.45 | 5,305 | BKX9VD3 |
| 0.19% | VCYT | VERACYTE INC | -- | $153,198.81 | 3,481 | BFTWZY0 |
| 0.18% | GRAL | GRAIL INC | -- | $149,212.25 | 1,595 | BSLSSX7 |
| 0.18% | TARS | TARSUS PHARMACEUTICALS INC | -- | $148,804.88 | 1,868 | BMH5RL1 |
| 0.18% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $143,227.76 | 4,264 | BJ62Z18 |
| 0.18% | CGON | CG ONCOLOGY INC | -- | $143,192.56 | 3,374 | BRBCSP4 |
| 0.18% | IRON | DISC MEDICINE INC | -- | $142,418.80 | 1,538 | BMGJZJ8 |
| 0.17% | XENE | XENON PHARMACEUTICALS INC | -- | $140,437.92 | 3,412 | BRJ3GY4 |
| 0.17% | TVTX | TRAVERE THERAPEUTICS INC | -- | $136,852.05 | 3,945 | BLFGJD5 |
| 0.17% | APGE | APOGEE THERAPEUTICS INC | -- | $135,170.40 | 2,040 | BM9HHL5 |
| 0.17% | DYN | DYNE THERAPEUTICS INC | -- | $133,328.10 | 6,295 | BN15WD1 |
| 0.16% | IDYA | IDEAYA BIOSCIENCES INC | -- | $131,813.22 | 3,878 | BK0VHF6 |
| 0.16% | FOLD | AMICUS THERAPEUTICS INC | -- | $130,379.28 | 13,638 | B19FQ48 |
| 0.16% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $125,375.57 | 6,737 | BJ5FZ74 |
| 0.15% | MLYS | MINERALYS THERAPEUTICS INC | -- | $122,804.71 | 2,933 | BP9N0G0 |
| 0.15% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $118,775.10 | 4,245 | BLB0YQ9 |
| 0.14% | DNLI | DENALI THERAPEUTICS INC | -- | $116,442.00 | 6,469 | BD2B4V0 |
| 0.14% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $112,438.92 | 2,481 | B72ZBG4 |
| 0.14% | APLS | APELLIS PHARMACEUTICALS INC | -- | $109,580.68 | 5,588 | BYTQ6X1 |
| 0.13% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $105,664.87 | 4,661 | BKY5JZ8 |
| 0.13% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $104,961.42 | 3,726 | BMX9K07 |
| 0.13% | TERN | TERNS PHARMACEUTICALS INC | -- | $101,891.68 | 3,872 | BMDJ0C9 |
| 0.12% | BEAM | BEAM THERAPEUTICS INC | -- | $99,411.96 | 4,476 | BK6L288 |
| 0.12% | AVDL | AVADEL PHARMACEUTICALS | -- | $98,936.88 | 4,296 | BDGMC59 |
| 0.12% | OCUL | OCULAR THERAPEUTIX INC | -- | $94,235.76 | 7,699 | BNZB1X8 |
| 0.11% | TXG | 10X GENOMICS INC-CLASS A | -- | $92,837.08 | 5,062 | BKS3RS7 |
| 0.11% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $91,320.32 | 5,824 | BFWLC09 |
| 0.11% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $90,467.52 | 2,636 | BQS9486 |
| 0.11% | VCEL | VERICEL CORP | -- | $88,382.14 | 2,233 | BSBMN89 |
| 0.11% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $87,353.26 | 2,546 | BKSGZN7 |
| 0.11% | IBRX | IMMUNITYBIO INC | -- | $86,991.84 | 41,823 | BNSP0B8 |
| 0.10% | VERA | VERA THERAPEUTICS INC | -- | $80,371.04 | 2,824 | BL55460 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $79,958.34 | 1,923 | BRXB0C0 |
| 0.10% | ZYME | ZYMEWORKS INC | -- | $79,890.52 | 3,326 | BPCQZY9 |
| 0.10% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $78,842.19 | 18,907 | BM9FJ13 |
| 0.09% | JANX | JANUX THERAPEUTICS INC | -- | $76,579.20 | 2,659 | BMFX8Y7 |
| 0.09% | ANIP | ANI PHARMACEUTICALS INC | -- | $76,531.20 | 960 | BCDWBX6 |
| 0.09% | SRPT | SAREPTA THERAPEUTICS INC | -- | $76,473.87 | 4,323 | B8DPDT7 |
| 0.09% | TWST | TWIST BIOSCIENCE CORP | -- | $76,283.76 | 2,671 | BGKG6G7 |
| 0.09% | ALVO | ALVOTECH SA | -- | $71,189.00 | 13,850 | BPNTJ34 |
| 0.09% | STOK | STOKE THERAPEUTICS INC | -- | $71,149.50 | 2,425 | BJQ05Z6 |
| 0.09% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $70,367.29 | 3,037 | BMZ4LN0 |
| 0.09% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $69,728.20 | 1,772 | BLCD809 |
| 0.08% | MNKD | MANNKIND CORP | -- | $68,287.28 | 13,576 | BF081J4 |
| 0.08% | QURE | UNIQURE NV | -- | $67,522.68 | 2,428 | BJFSR88 |
| 0.08% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $66,463.84 | 3,811 | BN7Q7R7 |
| 0.08% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $64,892.04 | 2,571 | BCBVTX1 |
| 0.08% | SYRE | SPYRE THERAPEUTICS INC | -- | $64,822.72 | 2,672 | BQBBDY8 |
| 0.08% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $64,737.36 | 9,288 | 2100362 |
| 0.08% | HROW | HARROW INC | -- | $63,695.67 | 1,637 | BHNDW86 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $62,925.16 | 1,394 | BX7RSN3 |
| 0.07% | TRVI | TREVI THERAPEUTICS INC | -- | $59,214.12 | 5,388 | BJH9ZN0 |
| 0.07% | NVCR | NOVOCURE LTD | -- | $59,116.65 | 4,947 | BYSS4X4 |
| 0.07% | INVA | INNOVIVA INC | -- | $58,436.48 | 2,788 | BDDXF67 |
| 0.07% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $58,013.02 | 5,189 | BRJZSK0 |
| 0.07% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $57,873.15 | 3,945 | BPCK358 |
| 0.07% | ARDX | ARDELYX INC | -- | $57,788.04 | 10,662 | BN89V40 |
| 0.07% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $57,006.75 | 2,621 | BMFD115 |
| 0.07% | NRIX | NURIX THERAPEUTICS INC | -- | $56,699.08 | 3,383 | BMVLGP2 |
| 0.07% | GMAB | GENMAB A/S -SP ADR | -- | $56,484.75 | 1,855 | BBC9WC7 |
| 0.07% | INBX | INHIBRX BIOSCIENCES INC | -- | $53,799.13 | 641 | BNSP8K3 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $53,502.57 | 2,057 | BNFWZS4 |
| 0.07% | URGN | UROGEN PHARMA LTD | -- | $52,955.89 | 2,047 | BZ7PJQ1 |
| 0.06% | RLAY | RELAY THERAPEUTICS INC | -- | $51,641.56 | 7,628 | BN2R582 |
| 0.06% | PGEN | PRECIGEN INC | -- | $51,153.92 | 13,184 | BKM5C84 |
| 0.06% | TSHA | TAYSHA GENE THERAPIES INC | -- | $50,573.30 | 12,070 | BNC1BX1 |
| 0.06% | CVAC | CUREVAC NV | -- | $50,108.86 | 9,962 | BN4RD42 |
| 0.06% | XNCR | XENCOR INC | -- | $50,085.72 | 3,156 | BGCYWN8 |
| 0.06% | ORIC | ORIC PHARMACEUTICALS INC | -- | $49,931.14 | 4,297 | BKVDFF7 |
| 0.06% | TYRA | TYRA BIOSCIENCES INC | -- | $49,800.96 | 2,358 | BMVNDH9 |
| 0.06% | WVE | WAVE LIFE SCIENCES LTD | -- | $49,639.05 | 7,041 | BYZG9R0 |
| 0.06% | TNGX | TANGO THERAPEUTICS INC | -- | $49,377.69 | 4,923 | BP2P6L0 |
| 0.06% | ANAB | ANAPTYSBIO INC | -- | $49,076.79 | 1,239 | BDRW1L7 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $48,800.35 | 7,145 | BLR7H87 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $48,600.04 | 1,283 | BKLCWZ3 |
| 0.06% | ORKA | ORUKA THERAPEUTICS INC | -- | $48,533.53 | 1,657 | BKVF0J2 |
| 0.06% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $47,085.00 | 3,139 | BJLKVS6 |
| 0.06% | NVAX | NOVAVAX INC | -- | $46,493.42 | 7,186 | BJDQXG4 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $46,409.22 | 13,222 | BL53SR3 |
| 0.06% | PCRX | PACIRA BIOSCIENCES INC | -- | $45,823.40 | 1,988 | B3X26D8 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $45,343.20 | 5,398 | B8K7T65 |
| 0.05% | RAPP | RAPPORT THERAPEUTICS INC | -- | $44,008.75 | 1,615 | BR3T9B6 |
| 0.05% | FTRE | FORTREA HOLDINGS INC | -- | $43,796.20 | 4,018 | BRXYZ57 |
| 0.05% | KURA | KURA ONCOLOGY INC | -- | $42,892.80 | 3,840 | BYZD465 |
| 0.05% | ZLAB | ZAI LAB LTD-ADR | -- | $42,342.30 | 2,115 | BD9GVY0 |
| 0.05% | EYPT | EYEPOINT PHARMACEUTICALS INC | -- | $41,724.00 | 3,050 | BMGS7L1 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $41,173.44 | 2,228 | BMNDK09 |
| 0.05% | NTLA | INTELLIA THERAPEUTICS INC | -- | $38,997.50 | 4,750 | BYZM6C2 |
| 0.05% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $38,863.26 | 2,733 | BP7KZP7 |
| 0.05% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $38,612.64 | 4,532 | BLB0YH0 |
| 0.05% | PSNL | PERSONALIS INC | -- | $38,180.52 | 3,924 | BJQ0608 |
| 0.05% | SANA | SANA BIOTECHNOLOGY INC | -- | $37,657.34 | 11,446 | BMFJJ97 |
| 0.05% | SVRA | SAVARA INC | -- | $37,623.24 | 7,647 | BYXGN81 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $37,508.63 | 901 | BL95N25 |
| 0.05% | ARVN | ARVINAS INC | -- | $37,451.52 | 3,251 | BDZ30Q0 |
| 0.05% | LENZ | LENZ THERAPEUTICS INC | -- | $37,304.72 | 1,262 | BQV0J03 |
| 0.05% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $36,694.71 | 794 | BQD3J33 |
| 0.05% | ERAS | ERASCA INC | -- | $36,648.92 | 12,551 | BNLYBF3 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $36,557.42 | 8,482 | BZ0QMB7 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $36,528.25 | 1,795 | BMGTLY5 |
| 0.04% | MNMD | MIND MEDICINE MINDMED INC | -- | $35,959.56 | 3,367 | BPQYY97 |
| 0.04% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $35,862.40 | 16,010 | BF0DMK7 |
| 0.04% | VIR | VIR BIOTECHNOLOGY INC | -- | $34,909.28 | 6,146 | BK4PZ38 |
| 0.04% | SPRY | ARS PHARMACEUTICALS INC | -- | $33,191.07 | 4,373 | BMCR7V2 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $32,107.93 | 2,089 | BQS7491 |
| 0.04% | CRMD | CORMEDIX INC | -- | $31,973.04 | 3,303 | BJ0LT31 |
| 0.04% | REPL | REPLIMUNE GROUP INC | -- | $31,776.80 | 3,454 | BDDVW37 |
| 0.04% | GERN | GERON CORP | -- | $31,616.48 | 28,229 | 2370381 |
| 0.04% | ALMS | ALUMIS INC | -- | $31,287.80 | 4,286 | BPLQG36 |
| 0.04% | KROS | KEROS THERAPEUTICS INC | -- | $31,249.83 | 1,797 | BM7V485 |
| 0.04% | ATXS | ASTRIA THERAPEUTICS INC | -- | $31,237.47 | 2,497 | BMYRFN8 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $30,619.16 | 5,353 | BYVQJ96 |
| 0.04% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $29,503.80 | 13,290 | B4N8MH9 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $29,173.70 | 2,227 | BD06CS0 |
| 0.03% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $28,255.29 | 3,297 | BYP80F1 |
| 0.03% | PRME | PRIME MEDICINE INC | -- | $28,085.31 | 7,737 | BPBJFM7 |
| 0.03% | ESPR | ESPERION THERAPEUTICS INC | -- | $27,476.68 | 8,921 | BBNBTD2 |
| 0.03% | OMER | OMEROS CORP | -- | $26,707.57 | 3,011 | B4NB858 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $26,550.14 | 3,559 | BFYQFJ2 |
| 0.03% | RGNX | REGENXBIO INC | -- | $26,373.00 | 2,235 | BZ0G875 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $24,963.36 | 2,382 | B91XRN2 |
| 0.03% | CGEM | CULLINAN THERAPEUTICS INC | -- | $24,754.58 | 2,614 | BM90J52 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $24,003.75 | 6,401 | BMCWKZ2 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $22,710.92 | 7,187 | B3MZ6K5 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $22,395.44 | 2,066 | BKLXFX5 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $21,644.34 | 2,389 | BQ6C357 |
| 0.03% | LXRX | LEXICON PHARMACEUTICALS INC | -- | $21,545.86 | 16,079 | BWFZX59 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $21,362.40 | 2,484 | BLFBZ32 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $21,042.00 | 2,520 | BMFK3H6 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $20,979.86 | 4,058 | BMC3HS7 |
| 0.03% | ANNX | ANNEXON INC | -- | $20,760.74 | 4,862 | BMVV9R5 |
| 0.02% | EOLS | EVOLUS INC | -- | $19,604.70 | 2,862 | BDRJH21 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $19,438.44 | 634 | B292NQ7 |
| 0.02% | ABSI | ABSCI CORP | -- | $19,384.88 | 6,616 | BN94K69 |
| 0.02% | HCM | HUTCHMED CHINA-ADR | -- | $19,208.00 | 1,372 | BYXV9H7 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $18,783.05 | 3,905 | BFY7DC4 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $18,501.12 | 3,168 | 2107437 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $17,015.13 | 1,683 | BP81RK8 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $16,694.45 | 7,165 | BN4JN37 |
| 0.02% | LYEL | LYELL IMMUNOPHARMA INC | -- | $16,260.50 | 850 | BTNMG41 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $16,191.50 | 3,445 | BQHN6C7 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $15,881.04 | 828 | BPBPCG8 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $14,954.56 | 2,749 | BP81R42 |
| 0.02% | AMRN | AMARIN CORP PLC -ADR | -- | $14,610.96 | 892 | BN72KB0 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $13,987.82 | 4,774 | BDFKQ07 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $13,563.17 | 1,913 | BSMLR16 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $13,481.72 | 3,787 | BMXNGZ6 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $13,329.00 | 4,443 | BZC0D70 |
| 0.02% | PYXS | PYXIS ONCOLOGY INC | -- | $13,171.20 | 2,744 | BLBR8D5 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $13,112.18 | 2,078 | BL5B6Z1 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $12,930.72 | 2,046 | BKDQKM6 |
| 0.02% | NGNE | NEUROGENE INC | -- | $12,657.86 | 631 | BS2F741 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $12,547.20 | 2,614 | B12W3P6 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $12,388.00 | 3,800 | BYTYP72 |
| 0.01% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $12,074.91 | 9,817 | BFZNYB7 |
| 0.01% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $12,042.58 | 946 | B9L5200 |
| 0.01% | FHTX | FOGHORN THERAPEUTICS INC | -- | $11,554.62 | 2,501 | BMF7DT9 |
| 0.01% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $10,915.02 | 8,874 | BFMLGR4 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $10,427.67 | 3,511 | BLN9Z50 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $10,257.72 | 2,454 | BY7RB53 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $10,182.40 | 2,368 | BP7L561 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $9,629.18 | 3,979 | BZ8FPH3 |
| 0.01% | OABI | OMNIAB INC | -- | $9,609.33 | 5,429 | BN13S71 |
| 0.01% | HUMA | HUMACYTE INC | -- | $8,548.54 | 7,007 | BMYTJP4 |
| 0.01% | RNAC | CARTESIAN THERAPEUTICS INC | -- | $8,326.00 | 1,150 | BQB9HM8 |
| 0.01% | PEPG | PEPGEN INC | -- | $8,067.56 | 1,451 | BMTX3D7 |
| 0.01% | MXCT | MAXCYTE INC | -- | $7,877.39 | 4,717 | BKMQF66 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $7,683.56 | 3,149 | BKX9NQ0 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $7,518.26 | 1,201 | BKC9SX3 |
| 0.01% | CDXS | CODEXIS INC | -- | $6,150.76 | 3,994 | B5LL2C2 |
| 0.01% | MRSN | MERSANA THERAPEUTICS INC | -- | $6,033.30 | 221 | BVPKH99 |
| 0.01% | NKTX | NKARTA INC | -- | $5,657.40 | 3,143 | BK80YJ8 |
| 0.01% | ALEC | ALECTOR INC | -- | $5,552.72 | 4,478 | BJ4LDC4 |
| 0.01% | FATE | FATE THERAPEUTICS INC | -- | $5,256.09 | 5,103 | BCZS820 |
| 0.01% | CLYM | CLIMB BIO INC | -- | $5,096.60 | 2,998 | BMW5LX6 |
| 0.01% | PLRX | PLIANT THERAPEUTICS INC | -- | $4,209.80 | 2,716 | BMDWW66 |
| -- | MGNX | MACROGENICS INC | -- | $3,971.80 | 2,837 | BFDV8K0 |
| -- | TVGN | TEVOGEN BIO HOLDINGS INC | -- | $3,924.18 | 8,703 | BPG5P75 |
| -- | ARTV | ARTIVA BIOTHERAPEUTICS INC | -- | $3,383.53 | 1,081 | BMF1LJ7 |
| -- | ACRV | ACRIVON THERAPEUTICS INC | -- | $3,201.60 | 1,392 | BP2TPK4 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $3,163.22 | 3,751 | BF12XC2 |
| -- | BMEA | BIOMEA FUSION INC | -- | $2,585.61 | 2,633 | BNKF6N0 |
| -- | TCRX | TSCAN THERAPEUTICS INC | -- | $2,235.62 | 2,322 | BNLYBJ7 |
| -- | APLT | APPLIED THERAPEUTICS INC | -- | $1,648.44 | 6,372 | BJL38Z1 |
| -- | OKUR | ONKURE THERAPEUTICS INC-A | -- | $1,465.44 | 568 | BT7KGT6 |
| -- | QTTB | Q32 BIO INC | -- | $1,080.00 | 540 | BS2FKQ4 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 35.37% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 28,557,322 | -- | 5,096 | -- |
| 35.09% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 28,333,167 | -- | 5,056 | -- |
| 21.34% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 17,231,900 | -- | 3,075 | -- |
| 17.24% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 13,920,013 | -- | 2,484 | -- |
| 15.96% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 12,883,297 | -- | 2,299 | -- |
| 8.02% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 6,472,470 | -- | 1,155 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $26,596,733.70 | 26,596,734 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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