BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 9/30/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 11/07/2025- NAV $69.56
- NAV Change $-0.70
- Market Price $69.53
- Market Price Change $-0.72
- Trading Volume (M) 57,977
- 30-Day Median Bid Ask Spread 0.30%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 11/07/2025- NAV $69.56
- NAV Change $-0.70
- Market Price $69.53
- Market Price Change $-0.72
- Trading Volume (M) 57,977
- 30-Day Median Bid Ask Spread 0.30%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 11/07/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.17% | AMGN | AMGEN INC | -- | $3,522,520.20 | 11,001 | 2023607 |
| 4.88% | GILD | GILEAD SCIENCES INC | -- | $3,329,777.96 | 28,019 | 2369174 |
| 4.86% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $3,314,659.65 | 8,095 | 2931034 |
| 3.81% | REGN | REGENERON PHARMACEUTICALS | -- | $2,598,558.56 | 3,952 | 2730190 |
| 3.23% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,201,547.10 | 4,973 | B00FWN1 |
| 2.46% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $1,675,360.64 | 19,808 | 2989044 |
| 2.25% | INSM | INSMED INC | -- | $1,533,914.20 | 8,086 | 2614487 |
| 1.47% | ARGX | ARGENX SE - ADR | -- | $1,000,795.15 | 1,171 | BDVLM39 |
| 1.28% | BIIB | BIOGEN INC | -- | $872,100.08 | 5,608 | 2455965 |
| 1.16% | INCY | INCYTE CORP | -- | $791,670.60 | 7,470 | 2471950 |
| 1.14% | UTHR | UNITED THERAPEUTICS CORP | -- | $776,614.30 | 1,730 | 2430412 |
| 1.05% | ILMN | ILLUMINA INC | -- | $716,650.10 | 5,879 | 2613990 |
| 0.94% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $637,628.16 | 16,536 | BMVP7Y0 |
| 0.93% | MEDP | MEDPACE HOLDINGS INC | -- | $632,747.10 | 1,074 | BDCBC61 |
| 0.85% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $577,939.41 | 3,793 | 2623911 |
| 0.79% | ROIV | ROIVANT SCIENCES LTD | -- | $538,615.02 | 26,121 | BMW4NZ9 |
| 0.76% | SMMT | SUMMIT THERAPEUTICS INC | -- | $516,566.52 | 28,414 | BMTVQS7 |
| 0.75% | SNY | SANOFI-ADR | -- | $509,660.58 | 10,263 | 2964557 |
| 0.68% | TEM | TEMPUS AI INC | -- | $461,776.68 | 6,453 | BSLSJJ0 |
| 0.68% | GH | GUARDANT HEALTH INC | -- | $461,354.40 | 4,770 | BFXC911 |
| 0.68% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $460,140.98 | 2,327 | BV9G6B8 |
| 0.66% | BBIO | BRIDGEBIO PHARMA INC | -- | $451,881.60 | 7,312 | BK1KWG8 |
| 0.66% | VTRS | VIATRIS INC | -- | $451,301.40 | 44,595 | BMWS3X9 |
| 0.66% | IONS | IONIS PHARMACEUTICALS INC | -- | $448,434.35 | 6,097 | BDJ0LS6 |
| 0.64% | RVMD | REVOLUTION MEDICINES INC | -- | $436,282.51 | 7,151 | BL71K91 |
| 0.62% | EXEL | EXELIXIS INC | -- | $420,220.57 | 10,297 | 2576941 |
| 0.61% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $416,849.52 | 852 | BD59BS7 |
| 0.60% | ONC | BEONE MEDICINES LTD-ADR | -- | $411,161.45 | 1,285 | BYYWPW6 |
| 0.58% | BNTX | BIONTECH SE-ADR | -- | $396,779.58 | 3,847 | BK6H543 |
| 0.55% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $377,973.70 | 7,345 | 2437071 |
| 0.54% | MRNA | MODERNA INC | -- | $365,204.28 | 14,882 | BGSXTS3 |
| 0.50% | RNA | AVIDITY BIOSCIENCES INC | -- | $343,682.64 | 4,921 | BMWHPY1 |
| 0.45% | HALO | HALOZYME THERAPEUTICS INC | -- | $305,305.76 | 4,474 | 2975098 |
| 0.45% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $304,291.20 | 2,320 | B4Q5ZN4 |
| 0.40% | MRUS | MERUS NV | -- | $275,500.39 | 2,893 | BZBY005 |
| 0.40% | CYTK | CYTOKINETICS INC | -- | $275,352.32 | 4,577 | BBBSBJ5 |
| 0.39% | AXSM | AXSOME THERAPEUTICS INC | -- | $263,590.20 | 1,908 | BYZR4X4 |
| 0.37% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $254,862.30 | 2,541 | BF2YWG4 |
| 0.35% | NUVL | NUVALENT INC-A | -- | $238,042.50 | 2,550 | BMVBZD3 |
| 0.32% | KRYS | KRYSTAL BIOTECH INC | -- | $219,108.51 | 1,107 | BD6JX35 |
| 0.32% | PTCT | PTC THERAPEUTICS INC | -- | $218,139.42 | 3,039 | B17VCN9 |
| 0.30% | ALKS | ALKERMES PLC | -- | $207,700.35 | 6,315 | B3P6D26 |
| 0.30% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $207,448.24 | 5,288 | BYQBFJ8 |
| 0.30% | PCVX | VAXCYTE INC | -- | $206,833.90 | 4,966 | BKPVGH6 |
| 0.28% | CRSP | CRISPR THERAPEUTICS AG | -- | $191,707.36 | 3,478 | BDHF4K6 |
| 0.28% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $189,225.66 | 2,379 | BDCBCD8 |
| 0.27% | ACLX | ARCELLX INC | -- | $183,572.55 | 2,121 | BPCJ1Q2 |
| 0.24% | AKRO | AKERO THERAPEUTICS INC | -- | $165,362.40 | 3,060 | BK7Y2V9 |
| 0.24% | KYMR | KYMERA THERAPEUTICS INC | -- | $160,435.10 | 2,735 | BMPRZV5 |
| 0.23% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $158,362.08 | 4,308 | BP8JSP4 |
| 0.23% | IMVT | IMMUNOVANT INC | -- | $155,697.80 | 6,668 | BJRFSB7 |
| 0.22% | LGND | LIGAND PHARMACEUTICALS | -- | $151,860.00 | 750 | 2501578 |
| 0.22% | INDV | INDIVIOR PLC | -- | $149,554.48 | 4,772 | BP0BQQ5 |
| 0.21% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $145,666.78 | 6,454 | 2713317 |
| 0.21% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $144,240.00 | 3,606 | BDD19F8 |
| 0.20% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $136,587.81 | 12,013 | BFNF1D6 |
| 0.20% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $135,417.10 | 805 | BQ721R4 |
| 0.19% | ADMA | ADMA BIOLOGICS INC | -- | $132,524.04 | 9,127 | B9NSBM2 |
| 0.19% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $130,907.42 | 1,922 | BJDX8Y8 |
| 0.18% | VCYT | VERACYTE INC | -- | $125,475.30 | 3,009 | BFTWZY0 |
| 0.17% | CGON | CG ONCOLOGY INC | -- | $115,746.56 | 2,917 | BRBCSP4 |
| 0.17% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $112,932.81 | 3,687 | BJ62Z18 |
| 0.17% | XENE | XENON PHARMACEUTICALS INC | -- | $112,799.25 | 2,949 | BRJ3GY4 |
| 0.16% | IRON | DISC MEDICINE INC | -- | $111,520.50 | 1,330 | BMGJZJ8 |
| 0.16% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $111,118.78 | 4,586 | BKX9VD3 |
| 0.16% | TVTX | TRAVERE THERAPEUTICS INC | -- | $110,279.40 | 3,410 | BLFGJD5 |
| 0.16% | TARS | TARSUS PHARMACEUTICALS INC | -- | $110,223.75 | 1,615 | BMH5RL1 |
| 0.16% | GRAL | GRAIL INC | -- | $109,492.60 | 1,379 | BSLSSX7 |
| 0.16% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $106,478.10 | 3,678 | BFZQ0L8 |
| 0.15% | FOLD | AMICUS THERAPEUTICS INC | -- | $104,586.17 | 11,791 | B19FQ48 |
| 0.15% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $102,396.00 | 3,220 | BMX9K07 |
| 0.15% | IDYA | IDEAYA BIOSCIENCES INC | -- | $101,364.48 | 3,352 | BK0VHF6 |
| 0.15% | DYN | DYNE THERAPEUTICS INC | -- | $99,915.12 | 5,442 | BN15WD1 |
| 0.14% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $98,712.90 | 2,145 | B72ZBG4 |
| 0.14% | APGE | APOGEE THERAPEUTICS INC | -- | $96,508.44 | 1,764 | BM9HHL5 |
| 0.14% | MLYS | MINERALYS THERAPEUTICS INC | -- | $96,418.72 | 2,536 | BP9N0G0 |
| 0.14% | APLS | APELLIS PHARMACEUTICALS INC | -- | $93,045.06 | 4,831 | BYTQ6X1 |
| 0.13% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $90,409.41 | 2,223 | BCBVTX1 |
| 0.13% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $86,136.96 | 5,824 | BJ5FZ74 |
| 0.13% | BEAM | BEAM THERAPEUTICS INC | -- | $85,952.70 | 3,870 | BK6L288 |
| 0.12% | DNLI | DENALI THERAPEUTICS INC | -- | $84,006.86 | 5,593 | BD2B4V0 |
| 0.12% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $81,158.28 | 3,669 | BLB0YQ9 |
| 0.12% | COGT | COGENT BIOSCIENCES INC | -- | $79,183.26 | 5,343 | BLR6XK8 |
| 0.11% | IBRX | IMMUNITYBIO INC | -- | $77,014.41 | 36,157 | BNSP0B8 |
| 0.11% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $75,513.90 | 16,345 | BM9FJ13 |
| 0.11% | VCEL | VERICEL CORP | -- | $75,154.20 | 1,930 | BSBMN89 |
| 0.11% | ANIP | ANI PHARMACEUTICALS INC | -- | $75,056.90 | 830 | BCDWBX6 |
| 0.11% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $74,875.20 | 2,280 | BQS9486 |
| 0.11% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $73,575.96 | 5,036 | BFWLC09 |
| 0.11% | OCUL | OCULAR THERAPEUTIX INC | -- | $72,206.75 | 6,655 | BNZB1X8 |
| 0.10% | TWST | TWIST BIOSCIENCE CORP | -- | $69,863.16 | 2,308 | BGKG6G7 |
| 0.10% | AVDL | AVADEL PHARMACEUTICALS | -- | $69,395.97 | 3,713 | BDGMC59 |
| 0.10% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $69,309.24 | 4,039 | BKY5JZ8 |
| 0.10% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $69,146.00 | 2,200 | BKSGZN7 |
| 0.10% | ALVO | ALVOTECH SA | -- | $68,360.12 | 11,972 | BPNTJ34 |
| 0.10% | TXG | 10X GENOMICS INC-CLASS A | -- | $66,749.25 | 4,377 | BKS3RS7 |
| 0.10% | MNKD | MANNKIND CORP | -- | $66,084.94 | 11,738 | BF081J4 |
| 0.10% | SRPT | SAREPTA THERAPEUTICS INC | -- | $65,900.94 | 3,738 | B8DPDT7 |
| 0.09% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $63,809.31 | 1,663 | BRXB0C0 |
| 0.09% | TERN | TERNS PHARMACEUTICALS INC | -- | $61,819.09 | 3,347 | BMDJ0C9 |
| 0.09% | JANX | JANUX THERAPEUTICS INC | -- | $60,851.04 | 2,298 | BMFX8Y7 |
| 0.09% | VERA | VERA THERAPEUTICS INC | -- | $59,071.98 | 2,442 | BL55460 |
| 0.09% | QURE | UNIQURE NV | -- | $58,331.21 | 2,099 | BJFSR88 |
| 0.08% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $56,932.70 | 8,030 | 2100362 |
| 0.08% | SYRE | SPYRE THERAPEUTICS INC | -- | $52,043.72 | 2,311 | BQBBDY8 |
| 0.08% | ARDX | ARDELYX INC | -- | $51,528.62 | 9,218 | BN89V40 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $51,322.00 | 1,532 | BLCD809 |
| 0.08% | TRVI | TREVI THERAPEUTICS INC | -- | $51,284.58 | 4,658 | BJH9ZN0 |
| 0.07% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $50,971.50 | 1,205 | BX7RSN3 |
| 0.07% | INVA | INNOVIVA INC | -- | $50,293.46 | 2,411 | BDDXF67 |
| 0.07% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $49,556.80 | 3,295 | BN7Q7R7 |
| 0.07% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $48,572.55 | 4,485 | BRJZSK0 |
| 0.07% | HROW | HARROW INC | -- | $48,010.95 | 1,415 | BHNDW86 |
| 0.07% | STOK | STOKE THERAPEUTICS INC | -- | $47,937.42 | 2,097 | BJQ05Z6 |
| 0.07% | WVE | WAVE LIFE SCIENCES LTD | -- | $47,843.82 | 6,087 | BYZG9R0 |
| 0.07% | ZYME | ZYMEWORKS INC | -- | $47,322.50 | 2,875 | BPCQZY9 |
| 0.07% | NVCR | NOVOCURE LTD | -- | $46,693.92 | 4,276 | BYSS4X4 |
| 0.07% | NVAX | NOVAVAX INC | -- | $46,224.72 | 6,213 | BJDQXG4 |
| 0.07% | GMAB | GENMAB A/S -SP ADR | -- | $45,941.98 | 1,603 | BBC9WC7 |
| 0.07% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $45,902.54 | 6,178 | BLR7H87 |
| 0.07% | ORIC | ORIC PHARMACEUTICALS INC | -- | $45,867.90 | 3,714 | BKVDFF7 |
| 0.07% | CVAC | CUREVAC NV | -- | $44,878.94 | 8,614 | BN4RD42 |
| 0.07% | INBX | INHIBRX BIOSCIENCES INC | -- | $44,782.95 | 555 | BNSP8K3 |
| 0.07% | ABCL | ABCELLERA BIOLOGICS INC | -- | $44,699.12 | 11,432 | BL53SR3 |
| 0.07% | PGEN | PRECIGEN INC | -- | $44,452.20 | 11,398 | BKM5C84 |
| 0.06% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $42,725.34 | 1,778 | BNFWZS4 |
| 0.06% | ANAB | ANAPTYSBIO INC | -- | $42,465.15 | 1,071 | BDRW1L7 |
| 0.06% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $41,989.41 | 3,411 | BPCK358 |
| 0.06% | URGN | UROGEN PHARMA LTD | -- | $41,134.80 | 1,770 | BZ7PJQ1 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $40,478.73 | 9,897 | BMFJJ97 |
| 0.06% | ZLAB | ZAI LAB LTD-ADR | -- | $40,077.00 | 1,830 | BD9GVY0 |
| 0.06% | TSHA | TAYSHA GENE THERAPIES INC | -- | $39,966.05 | 10,435 | BNC1BX1 |
| 0.06% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $39,949.58 | 2,266 | BMFD115 |
| 0.06% | RLAY | RELAY THERAPEUTICS INC | -- | $39,899.75 | 6,595 | BN2R582 |
| 0.06% | ORKA | ORUKA THERAPEUTICS INC | -- | $39,765.75 | 1,433 | BKVF0J2 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $39,381.04 | 4,666 | B8K7T65 |
| 0.06% | NTLA | INTELLIA THERAPEUTICS INC | -- | $39,079.60 | 4,105 | BYZM6C2 |
| 0.06% | FTRE | FORTREA HOLDINGS INC | -- | $39,026.25 | 3,469 | BRXYZ57 |
| 0.06% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $38,131.87 | 3,919 | BLB0YH0 |
| 0.06% | XNCR | XENCOR INC | -- | $37,919.20 | 2,728 | BGCYWN8 |
| 0.06% | PCRX | PACIRA BIOSCIENCES INC | -- | $37,903.95 | 1,719 | B3X26D8 |
| 0.05% | CSTL | CASTLE BIOSCIENCES INC | -- | $36,641.36 | 1,109 | BKLCWZ3 |
| 0.05% | NRIX | NURIX THERAPEUTICS INC | -- | $36,006.75 | 2,925 | BMVLGP2 |
| 0.05% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $35,947.25 | 2,713 | BJLKVS6 |
| 0.05% | RAPP | RAPPORT THERAPEUTICS INC | -- | $35,821.36 | 1,396 | BR3T9B6 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $34,089.04 | 779 | BL95N25 |
| 0.05% | MNMD | MIND MEDICINE MINDMED INC | -- | $34,058.70 | 2,911 | BPQYY97 |
| 0.05% | TNGX | TANGO THERAPEUTICS INC | -- | $33,494.72 | 4,256 | BP2P6L0 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $33,453.00 | 3,780 | BMCR7V2 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $33,003.00 | 7,334 | BZ0QMB7 |
| 0.05% | KURA | KURA ONCOLOGY INC | -- | $32,745.06 | 3,321 | BYZD465 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $31,838.90 | 13,843 | BF0DMK7 |
| 0.05% | CRMD | CORMEDIX INC | -- | $30,730.56 | 2,856 | BJ0LT31 |
| 0.04% | ARVN | ARVINAS INC | -- | $29,849.04 | 2,808 | BDZ30Q0 |
| 0.04% | EYPT | EYEPOINT PHARMACEUTICALS INC | -- | $29,549.56 | 2,636 | BMGS7L1 |
| 0.04% | TYRA | TYRA BIOSCIENCES INC | -- | $29,184.16 | 2,038 | BMVNDH9 |
| 0.04% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $29,088.53 | 2,363 | BP7KZP7 |
| 0.04% | TBPH | THERAVANCE BIOPHARMA INC | -- | $28,408.50 | 1,926 | BMNDK09 |
| 0.04% | AVBP | ARRIVENT BIOPHARMA INC | -- | $27,987.80 | 1,551 | BMGTLY5 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $27,953.12 | 4,628 | BYVQJ96 |
| 0.04% | VIR | VIR BIOTECHNOLOGY INC | -- | $27,260.82 | 5,314 | BK4PZ38 |
| 0.04% | ATXS | ASTRIA THERAPEUTICS INC | -- | $27,009.09 | 2,159 | BMYRFN8 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $26,385.66 | 1,806 | BQS7491 |
| 0.04% | SVRA | SAVARA INC | -- | $26,117.40 | 6,612 | BYXGN81 |
| 0.04% | GERN | GERON CORP | -- | $26,113.35 | 24,405 | 2370381 |
| 0.04% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $26,062.19 | 3,077 | BFYQFJ2 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $25,488.90 | 6,690 | BPBJFM7 |
| 0.04% | KROS | KEROS THERAPEUTICS INC | -- | $25,158.60 | 1,553 | BM7V485 |
| 0.04% | LENZ | LENZ THERAPEUTICS INC | -- | $25,060.27 | 1,091 | BQV0J03 |
| 0.04% | REPL | REPLIMUNE GROUP INC | -- | $24,813.66 | 2,986 | BDDVW37 |
| 0.04% | ERAS | ERASCA INC | -- | $24,634.04 | 10,852 | BNLYBF3 |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $24,175.53 | 687 | BQD3J33 |
| 0.04% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $23,947.65 | 3,285 | BYTYP72 |
| 0.03% | PSNL | PERSONALIS INC | -- | $23,506.56 | 3,392 | BJQ0608 |
| 0.03% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $21,918.75 | 2,625 | BMZ4LN0 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $21,743.04 | 2,059 | B91XRN2 |
| 0.03% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $21,667.60 | 2,851 | BYP80F1 |
| 0.03% | RGNX | REGENXBIO INC | -- | $21,657.72 | 1,932 | BZ0G875 |
| 0.03% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $20,762.28 | 1,926 | BD06CS0 |
| 0.03% | ESPR | ESPERION THERAPEUTICS INC | -- | $20,516.58 | 7,713 | BBNBTD2 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $20,222.40 | 11,490 | B4N8MH9 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $19,118.60 | 3,508 | BMC3HS7 |
| 0.03% | ABSI | ABSCI CORP | -- | $19,079.54 | 5,721 | BN94K69 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $18,923.88 | 2,148 | BLFBZ32 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $18,763.50 | 1,787 | BKLXFX5 |
| 0.03% | SIGA | SIGA TECHNOLOGIES INC | -- | $17,926.14 | 2,741 | 2107437 |
| 0.03% | HCM | HUTCHMED CHINA-ADR | -- | $17,745.65 | 1,187 | BYXV9H7 |
| 0.03% | ALMS | ALUMIS INC | -- | $17,492.32 | 3,706 | BPLQG36 |
| 0.03% | LXRX | LEXICON PHARMACEUTICALS INC | -- | $17,376.25 | 13,901 | BWFZX59 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $17,278.44 | 548 | B292NQ7 |
| 0.03% | OMER | OMEROS CORP | -- | $17,160.36 | 2,604 | B4NB858 |
| 0.02% | LXEO | LEXEO THERAPEUTICS INC | -- | $16,912.35 | 2,065 | BQ6C357 |
| 0.02% | DSGN | DESIGN THERAPEUTICS INC | -- | $16,473.24 | 2,179 | BMFK3H6 |
| 0.02% | CGEM | CULLINAN THERAPEUTICS INC | -- | $16,249.40 | 2,260 | BM90J52 |
| 0.02% | EOLS | EVOLUS INC | -- | $16,236.00 | 2,475 | BDRJH21 |
| 0.02% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $15,888.32 | 5,536 | BMCWKZ2 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $15,861.76 | 6,196 | BN4JN37 |
| 0.02% | NGNE | NEUROGENE INC | -- | $14,605.50 | 546 | BS2F741 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $13,879.47 | 3,377 | BFY7DC4 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $13,813.80 | 715 | BPBPCG8 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $13,088.93 | 4,129 | BDFKQ07 |
| 0.02% | LYEL | LYELL IMMUNOPHARMA INC | -- | $12,887.36 | 736 | BTNMG41 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $12,716.95 | 2,377 | BP81R42 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $12,675.30 | 3,841 | BZC0D70 |
| 0.02% | AMRN | AMARIN CORP PLC -ADR | -- | $12,112.41 | 771 | BN72KB0 |
| 0.02% | ANNX | ANNEXON INC | -- | $12,110.40 | 4,205 | BMVV9R5 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $12,094.74 | 2,979 | BQHN6C7 |
| 0.02% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $11,930.88 | 6,214 | B3MZ6K5 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $11,817.68 | 1,796 | BL5B6Z1 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $11,392.36 | 1,769 | BKDQKM6 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $11,328.04 | 3,274 | BMXNGZ6 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $10,889.90 | 1,655 | BSMLR16 |
| 0.01% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $10,203.76 | 7,672 | BFMLGR4 |
| 0.01% | TRDA | ENTRADA THERAPEUTICS INC | -- | $10,060.96 | 1,456 | BP81RK8 |
| 0.01% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $10,015.84 | 8,488 | BFZNYB7 |
| 0.01% | VNDA | VANDA PHARMACEUTICALS INC | -- | $9,944.00 | 2,260 | B12W3P6 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $9,927.72 | 3,036 | BLN9Z50 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $9,641.37 | 2,047 | BP7L561 |
| 0.01% | FHTX | FOGHORN THERAPEUTICS INC | -- | $9,430.68 | 2,163 | BMF7DT9 |
| 0.01% | PYXS | PYXIS ONCOLOGY INC | -- | $9,278.43 | 2,373 | BLBR8D5 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $9,060.08 | 1,039 | BKC9SX3 |
| 0.01% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $8,989.82 | 818 | B9L5200 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $8,976.06 | 2,122 | BY7RB53 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $8,496.80 | 3,440 | BZ8FPH3 |
| 0.01% | HUMA | HUMACYTE INC | -- | $8,058.47 | 6,059 | BMYTJP4 |
| 0.01% | RNAC | CARTESIAN THERAPEUTICS INC | -- | $7,830.65 | 995 | BQB9HM8 |
| 0.01% | OABI | OMNIAB INC | -- | $6,477.72 | 4,694 | BN13S71 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $6,374.16 | 2,724 | BKX9NQ0 |
| 0.01% | MXCT | MAXCYTE INC | -- | $5,873.76 | 4,079 | BKMQF66 |
| 0.01% | CDXS | CODEXIS INC | -- | $5,835.57 | 3,453 | B5LL2C2 |
| 0.01% | PEPG | PEPGEN INC | -- | $5,798.10 | 1,255 | BMTX3D7 |
| 0.01% | NKTX | NKARTA INC | -- | $5,327.28 | 2,718 | BK80YJ8 |
| 0.01% | ALEC | ALECTOR INC | -- | $4,957.44 | 3,873 | BJ4LDC4 |
| 0.01% | CLYM | CLIMB BIO INC | -- | $4,745.19 | 2,593 | BMW5LX6 |
| 0.01% | FATE | FATE THERAPEUTICS INC | -- | $4,720.84 | 4,412 | BCZS820 |
| 0.01% | APLT | APPLIED THERAPEUTICS INC | -- | $4,682.65 | 5,509 | BJL38Z1 |
| 0.01% | PLRX | PLIANT THERAPEUTICS INC | -- | $3,758.40 | 2,349 | BMDWW66 |
| 0.01% | TVGN | TEVOGEN BIO HOLDINGS INC | -- | $3,755.73 | 7,525 | BPG5P75 |
| -- | MGNX | MACROGENICS INC | -- | $3,314.03 | 2,419 | BFDV8K0 |
| -- | ARTV | ARTIVA BIOTHERAPEUTICS INC | -- | $3,235.10 | 935 | BMF1LJ7 |
| -- | BMEA | BIOMEA FUSION INC | -- | $3,120.86 | 2,278 | BNKF6N0 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $2,648.89 | 3,245 | BF12XC2 |
| -- | ACRV | ACRIVON THERAPEUTICS INC | -- | $2,263.52 | 1,204 | BP2TPK4 |
| -- | TCRX | TSCAN THERAPEUTICS INC | -- | $2,188.72 | 2,008 | BNLYBJ7 |
| -- | MRSN | MERSANA THERAPEUTICS INC | -- | $1,614.72 | 192 | BVPKH99 |
| -- | OKUR | ONKURE THERAPEUTICS INC-A | -- | $1,446.48 | 492 | BT7KGT6 |
| -- | QTTB | Q32 BIO INC | -- | $1,057.68 | 468 | BS2FKQ4 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 36.82% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 25,095,489 | -- | 4,737 | -- |
| 28.05% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 19,119,616 | -- | 3,609 | -- |
| 23.90% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 16,290,612 | -- | 3,075 | -- |
| 19.31% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 13,159,636 | -- | 2,484 | -- |
| 17.87% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 12,179,550 | -- | 2,299 | -- |
| 8.98% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 6,118,913 | -- | 1,155 | -- |
| -- | -- | TREASURY BILL | -- | $4,994,770.85 | 5,000,000 | BMGHP58 |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $18,919,321.72 | 18,919,322 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
Read More