BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 8/31/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 9.47% | 28.93% | 1.11% | 9.77% | -16.62% | 3.73% | -4.43% | -2.92% | 14.03% | 04/07/2010 |
| BIB NAV | 9.35% | 28.93% | 1.18% | 9.85% | -16.62% | 3.78% | -4.40% | -2.92% | 14.03% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 6.88% | -4.57% | -9.00% | -9.00% | -21.42% | -1.05% | -8.38% | -6.36% | 12.80% | 04/07/2010 |
| BIB NAV | 6.82% | -4.48% | -9.00% | -9.00% | -21.46% | -1.12% | -8.40% | -6.35% | 12.79% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 10/01/2025- NAV $62.66
- NAV Change $+3.11
- Market Price $62.64
- Market Price Change $+3.07
- Trading Volume (M) 23,343
- 30-Day Median Bid Ask Spread 0.24%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 10/01/2025- NAV $62.66
- NAV Change $+3.11
- Market Price $62.64
- Market Price Change $+3.07
- Trading Volume (M) 23,343
- 30-Day Median Bid Ask Spread 0.24%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 6/30/2025
Holdings
as of 10/01/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.03% | AMGN | AMGEN INC | -- | $3,058,431.00 | 10,246 | 2023607 |
| 5.01% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $3,047,339.19 | 7,539 | 2931034 |
| 4.77% | GILD | GILEAD SCIENCES INC | -- | $2,900,459.25 | 26,095 | 2369174 |
| 3.63% | REGN | REGENERON PHARMACEUTICALS | -- | $2,207,779.20 | 3,680 | 2730190 |
| 3.51% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,133,270.15 | 4,631 | B00FWN1 |
| 2.56% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $1,556,273.28 | 18,448 | 2989044 |
| 1.82% | INSM | INSMED INC | -- | $1,109,018.40 | 7,530 | 2614487 |
| 1.38% | ARGX | ARGENX SE - ADR | -- | $837,157.03 | 1,091 | BDVLM39 |
| 1.33% | BIIB | BIOGEN INC | -- | $805,491.06 | 5,223 | 2455965 |
| 1.16% | UTHR | UNITED THERAPEUTICS CORP | -- | $705,907.98 | 1,611 | 2430412 |
| 0.99% | INCY | INCYTE CORP | -- | $603,085.20 | 6,956 | 2471950 |
| 0.92% | ILMN | ILLUMINA INC | -- | $559,873.50 | 5,475 | 2613990 |
| 0.92% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $559,654.88 | 15,409 | BMVP7Y0 |
| 0.90% | MEDP | MEDPACE HOLDINGS INC | -- | $544,443.90 | 1,001 | BDCBC61 |
| 0.89% | SMMT | SUMMIT THERAPEUTICS INC | -- | $542,226.87 | 26,463 | BMTVQS7 |
| 0.87% | TEM | TEMPUS AI INC | -- | $528,731.91 | 6,009 | BSLSJJ0 |
| 0.80% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $484,021.00 | 3,533 | 2623911 |
| 0.78% | SNY | SANOFI-ADR | -- | $475,655.84 | 9,559 | 2964557 |
| 0.73% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $442,510.48 | 2,168 | BV9G6B8 |
| 0.69% | VTRS | VIATRIS INC | -- | $419,067.97 | 41,533 | BMWS3X9 |
| 0.66% | ONC | BEONE MEDICINES LTD-ADR | -- | $401,186.52 | 1,197 | BYYWPW6 |
| 0.65% | EXEL | EXELIXIS INC | -- | $395,108.00 | 9,590 | 2576941 |
| 0.63% | ROIV | ROIVANT SCIENCES LTD | -- | $383,150.25 | 24,327 | BMW4NZ9 |
| 0.63% | MRNA | MODERNA INC | -- | $382,536.00 | 13,860 | BGSXTS3 |
| 0.62% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $375,242.40 | 6,840 | 2437071 |
| 0.61% | IONS | IONIS PHARMACEUTICALS INC | -- | $373,612.40 | 5,678 | BDJ0LS6 |
| 0.60% | BNTX | BIONTECH SE-ADR | -- | $366,320.64 | 3,584 | BK6H543 |
| 0.60% | BBIO | BRIDGEBIO PHARMA INC | -- | $364,198.80 | 6,810 | BK1KWG8 |
| 0.59% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $356,617.16 | 794 | BD59BS7 |
| 0.53% | VRNA | VERONA PHARMA PLC - ADR | -- | $322,916.86 | 3,023 | BYWPZK5 |
| 0.51% | HALO | HALOZYME THERAPEUTICS INC | -- | $312,274.98 | 4,167 | 2975098 |
| 0.50% | RVMD | REVOLUTION MEDICINES INC | -- | $305,473.46 | 6,661 | BL71K91 |
| 0.49% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $295,840.90 | 2,161 | B4Q5ZN4 |
| 0.46% | GH | GUARDANT HEALTH INC | -- | $278,291.30 | 4,442 | BFXC911 |
| 0.42% | MRUS | MERUS NV | -- | $253,640.10 | 2,694 | BZBY005 |
| 0.39% | CYTK | CYTOKINETICS INC | -- | $238,045.92 | 4,263 | BBBSBJ5 |
| 0.39% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $236,623.66 | 2,366 | BF2YWG4 |
| 0.35% | CRSP | CRISPR THERAPEUTICS AG | -- | $214,358.40 | 3,240 | BDHF4K6 |
| 0.35% | AXSM | AXSOME THERAPEUTICS INC | -- | $210,817.46 | 1,778 | BYZR4X4 |
| 0.32% | RNA | AVIDITY BIOSCIENCES INC | -- | $197,069.00 | 4,583 | BMWHPY1 |
| 0.32% | NUVL | NUVALENT INC-A | -- | $196,127.50 | 2,375 | BMVBZD3 |
| 0.30% | KRYS | KRYSTAL BIOTECH INC | -- | $185,177.91 | 1,031 | BD6JX35 |
| 0.30% | ALKS | ALKERMES PLC | -- | $180,252.65 | 5,881 | B3P6D26 |
| 0.29% | PCVX | VAXCYTE INC | -- | $175,888.75 | 4,625 | BKPVGH6 |
| 0.29% | PTCT | PTC THERAPEUTICS INC | -- | $175,488.30 | 2,830 | B17VCN9 |
| 0.28% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $172,424.25 | 4,925 | BYQBFJ8 |
| 0.27% | ACLX | ARCELLX INC | -- | $162,091.28 | 1,976 | BPCJ1Q2 |
| 0.23% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $141,824.00 | 2,216 | BDCBCD8 |
| 0.23% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $139,601.55 | 3,355 | BDD19F8 |
| 0.23% | KYMR | KYMERA THERAPEUTICS INC | -- | $139,219.02 | 2,547 | BMPRZV5 |
| 0.22% | AKRO | AKERO THERAPEUTICS INC | -- | $132,667.50 | 2,850 | BK7Y2V9 |
| 0.22% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $130,670.00 | 1,790 | BJDX8Y8 |
| 0.21% | ADMA | ADMA BIOLOGICS INC | -- | $127,940.05 | 8,501 | B9NSBM2 |
| 0.21% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $127,652.40 | 6,010 | 2713317 |
| 0.21% | LGND | LIGAND PHARMACEUTICALS | -- | $124,994.35 | 698 | 2501578 |
| 0.20% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $118,848.36 | 3,427 | BFZQ0L8 |
| 0.19% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $117,792.32 | 4,012 | BP8JSP4 |
| 0.19% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $116,141.82 | 11,189 | BFNF1D6 |
| 0.18% | QURE | UNIQURE NV | -- | $107,505.45 | 1,955 | BJFSR88 |
| 0.18% | XENE | XENON PHARMACEUTICALS INC | -- | $107,462.64 | 2,747 | BRJ3GY4 |
| 0.18% | CGON | CG ONCOLOGY INC | -- | $107,173.36 | 2,716 | BRBCSP4 |
| 0.17% | INDV | INDIVIOR PLC | -- | $104,279.70 | 4,445 | BP0BQQ5 |
| 0.17% | APLS | APELLIS PHARMACEUTICALS INC | -- | $103,926.90 | 4,499 | BYTQ6X1 |
| 0.17% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $102,955.67 | 3,433 | BJ62Z18 |
| 0.17% | VCYT | VERACYTE INC | -- | $101,496.63 | 2,803 | BFTWZY0 |
| 0.17% | IMVT | IMMUNOVANT INC | -- | $101,471.40 | 6,210 | BJRFSB7 |
| 0.16% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $97,980.00 | 3,000 | BMX9K07 |
| 0.16% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $95,983.92 | 1,998 | B72ZBG4 |
| 0.15% | MLYS | MINERALYS THERAPEUTICS INC | -- | $94,031.22 | 2,362 | BP9N0G0 |
| 0.15% | ALVO | ALVOTECH SA | -- | $91,326.69 | 11,151 | BPNTJ34 |
| 0.14% | BEAM | BEAM THERAPEUTICS INC | -- | $86,964.52 | 3,604 | BK6L288 |
| 0.14% | TARS | TARSUS PHARMACEUTICALS INC | -- | $86,239.36 | 1,504 | BMH5RL1 |
| 0.14% | IDYA | IDEAYA BIOSCIENCES INC | -- | $85,417.92 | 3,122 | BK0VHF6 |
| 0.14% | FOLD | AMICUS THERAPEUTICS INC | -- | $84,663.51 | 10,981 | B19FQ48 |
| 0.14% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $84,394.96 | 4,271 | BKX9VD3 |
| 0.14% | IBRX | IMMUNITYBIO INC | -- | $83,509.04 | 33,673 | BNSP0B8 |
| 0.14% | IRON | DISC MEDICINE INC | -- | $82,995.52 | 1,238 | BMGJZJ8 |
| 0.14% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $82,944.90 | 2,070 | BCBVTX1 |
| 0.13% | GRAL | GRAIL INC | -- | $79,685.04 | 1,284 | BSLSSX7 |
| 0.13% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $78,988.00 | 5,425 | BJ5FZ74 |
| 0.13% | TVTX | TRAVERE THERAPEUTICS INC | -- | $78,708.25 | 3,175 | BLFGJD5 |
| 0.13% | DNLI | DENALI THERAPEUTICS INC | -- | $77,666.19 | 5,209 | BD2B4V0 |
| 0.13% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $77,632.20 | 15,222 | BM9FJ13 |
| 0.13% | ETNB | 89BIO INC | -- | $77,607.27 | 5,283 | BK1K484 |
| 0.13% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $77,315.16 | 3,418 | BLB0YQ9 |
| 0.12% | NTLA | INTELLIA THERAPEUTICS INC | -- | $71,738.24 | 3,824 | BYZM6C2 |
| 0.12% | COGT | COGENT BIOSCIENCES INC | -- | $70,325.01 | 4,977 | BLR6XK8 |
| 0.11% | ANIP | ANI PHARMACEUTICALS INC | -- | $69,705.28 | 773 | BCDWBX6 |
| 0.11% | OCUL | OCULAR THERAPEUTIX INC | -- | $68,425.92 | 6,198 | BNZB1X8 |
| 0.11% | SRPT | SAREPTA THERAPEUTICS INC | -- | $67,252.92 | 3,481 | B8DPDT7 |
| 0.11% | VERA | VERA THERAPEUTICS INC | -- | $65,468.46 | 2,274 | BL55460 |
| 0.11% | APGE | APOGEE THERAPEUTICS INC | -- | $64,701.34 | 1,643 | BM9HHL5 |
| 0.10% | HROW | HARROW INC | -- | $63,751.66 | 1,318 | BHNDW86 |
| 0.10% | ABCL | ABCELLERA BIOLOGICS INC | -- | $63,450.16 | 10,646 | BL53SR3 |
| 0.10% | DYN | DYNE THERAPEUTICS INC | -- | $63,350.00 | 5,068 | BN15WD1 |
| 0.10% | TWST | TWIST BIOSCIENCE CORP | -- | $62,909.00 | 2,150 | BGKG6G7 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $59,853.36 | 1,549 | BRXB0C0 |
| 0.10% | MNKD | MANNKIND CORP | -- | $58,803.40 | 10,930 | BF081J4 |
| 0.10% | ZLAB | ZAI LAB LTD-ADR | -- | $58,651.32 | 1,703 | BD9GVY0 |
| 0.10% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $57,946.32 | 3,753 | BKY5JZ8 |
| 0.09% | NVCR | NOVOCURE LTD | -- | $55,682.34 | 3,983 | BYSS4X4 |
| 0.09% | VCEL | VERICEL CORP | -- | $55,576.18 | 1,798 | BSBMN89 |
| 0.09% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $55,282.92 | 2,123 | BQS9486 |
| 0.09% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $55,186.00 | 2,050 | BKSGZN7 |
| 0.09% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $55,112.86 | 7,478 | 2100362 |
| 0.09% | NVAX | NOVAVAX INC | -- | $54,910.00 | 5,780 | BJDQXG4 |
| 0.09% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $53,454.60 | 4,689 | BFWLC09 |
| 0.09% | AVDL | AVADEL PHARMACEUTICALS | -- | $51,885.00 | 3,459 | BDGMC59 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $51,272.11 | 1,427 | BLCD809 |
| 0.08% | JANX | JANUX THERAPEUTICS INC | -- | $50,741.70 | 2,141 | BMFX8Y7 |
| 0.08% | TXG | 10X GENOMICS INC-CLASS A | -- | $50,501.64 | 4,076 | BKS3RS7 |
| 0.08% | LENZ | LENZ THERAPEUTICS INC | -- | $49,834.80 | 1,016 | BQV0J03 |
| 0.08% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $48,121.92 | 3,069 | BN7Q7R7 |
| 0.08% | GMAB | GENMAB A/S -SP ADR | -- | $47,496.15 | 1,495 | BBC9WC7 |
| 0.08% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $46,081.53 | 5,753 | BLR7H87 |
| 0.08% | STOK | STOKE THERAPEUTICS INC | -- | $46,047.68 | 1,952 | BJQ05Z6 |
| 0.08% | ARDX | ARDELYX INC | -- | $46,015.60 | 8,585 | BN89V40 |
| 0.07% | ZYME | ZYMEWORKS INC | -- | $45,365.32 | 2,678 | BPCQZY9 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $44,695.44 | 1,656 | BNFWZS4 |
| 0.07% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $44,506.00 | 3,179 | BPCK358 |
| 0.07% | TRML | TOURMALINE BIO INC | -- | $43,791.90 | 915 | BQ80NC6 |
| 0.07% | GRFS | GRIFOLS SA-ADR | -- | $43,329.62 | 4,346 | B8K7T65 |
| 0.07% | CVAC | CUREVAC NV | -- | $43,313.40 | 8,021 | BN4RD42 |
| 0.07% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $42,949.84 | 4,178 | BRJZSK0 |
| 0.07% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $41,830.75 | 2,110 | BMFD115 |
| 0.07% | INVA | INNOVIVA INC | -- | $40,791.65 | 2,245 | BDDXF67 |
| 0.07% | TRVI | TREVI THERAPEUTICS INC | -- | $40,777.20 | 4,338 | BJH9ZN0 |
| 0.07% | ORIC | ORIC PHARMACEUTICALS INC | -- | $40,481.47 | 3,457 | BKVDFF7 |
| 0.07% | PCRX | PACIRA BIOSCIENCES INC | -- | $40,457.27 | 1,601 | B3X26D8 |
| 0.07% | WVE | WAVE LIFE SCIENCES LTD | -- | $39,853.07 | 5,669 | BYZG9R0 |
| 0.07% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $39,765.00 | 750 | BQ721R4 |
| 0.06% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $39,460.74 | 1,122 | BX7RSN3 |
| 0.06% | RAPP | RAPPORT THERAPEUTICS INC | -- | $37,271.00 | 1,300 | BR3T9B6 |
| 0.06% | SPRY | ARS PHARMACEUTICALS INC | -- | $35,526.89 | 3,521 | BMCR7V2 |
| 0.06% | PGEN | PRECIGEN INC | -- | $35,454.10 | 10,615 | BKM5C84 |
| 0.06% | SYRE | SPYRE THERAPEUTICS INC | -- | $35,421.92 | 2,152 | BQBBDY8 |
| 0.06% | PRME | PRIME MEDICINE INC | -- | $34,820.11 | 6,229 | BPBJFM7 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $34,099.20 | 9,216 | BMFJJ97 |
| 0.05% | MNMD | MIND MEDICINE MINDMED INC | -- | $33,426.63 | 2,711 | BPQYY97 |
| 0.05% | RLAY | RELAY THERAPEUTICS INC | -- | $32,675.44 | 6,142 | BN2R582 |
| 0.05% | GERN | GERON CORP | -- | $32,047.89 | 22,729 | 2370381 |
| 0.05% | ANAB | ANAPTYSBIO INC | -- | $31,874.09 | 997 | BDRW1L7 |
| 0.05% | EYPT | EYEPOINT PHARMACEUTICALS INC | -- | $31,706.33 | 2,455 | BMGS7L1 |
| 0.05% | TNGX | TANGO THERAPEUTICS INC | -- | $31,612.90 | 3,964 | BP2P6L0 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $31,345.11 | 6,829 | BZ0QMB7 |
| 0.05% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $31,056.83 | 2,527 | BJLKVS6 |
| 0.05% | TSHA | TAYSHA GENE THERAPIES INC | -- | $30,903.24 | 9,718 | BNC1BX1 |
| 0.05% | FTRE | FORTREA HOLDINGS INC | -- | $30,797.20 | 3,235 | BRXYZ57 |
| 0.05% | XNCR | XENCOR INC | -- | $30,060.03 | 2,541 | BGCYWN8 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $29,620.80 | 726 | BL95N25 |
| 0.05% | CRMD | CORMEDIX INC | -- | $29,381.95 | 2,659 | BJ0LT31 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $29,359.12 | 1,648 | BZ7PJQ1 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $28,489.11 | 12,891 | BF0DMK7 |
| 0.05% | KURA | KURA ONCOLOGY INC | -- | $28,446.40 | 3,092 | BYZD465 |
| 0.05% | VIR | VIR BIOTECHNOLOGY INC | -- | $28,209.30 | 4,949 | BK4PZ38 |
| 0.05% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $27,570.60 | 3,060 | BYTYP72 |
| 0.05% | MESO | MESOBLAST LTD- SPON ADR | -- | $27,366.14 | 1,682 | BQS7491 |
| 0.04% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $26,992.80 | 2,445 | BMZ4LN0 |
| 0.04% | AVBP | ARRIVENT BIOPHARMA INC | -- | $26,674.70 | 1,445 | BMGTLY5 |
| 0.04% | TBPH | THERAVANCE BIOPHARMA INC | -- | $25,869.48 | 1,794 | BMNDK09 |
| 0.04% | NRIX | NURIX THERAPEUTICS INC | -- | $25,596.20 | 2,723 | BMVLGP2 |
| 0.04% | TYRA | TYRA BIOSCIENCES INC | -- | $25,484.58 | 1,899 | BMVNDH9 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $25,342.80 | 4,310 | BYVQJ96 |
| 0.04% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $25,105.12 | 3,649 | BLB0YH0 |
| 0.04% | ORKA | ORUKA THERAPEUTICS INC | -- | $24,839.08 | 1,334 | BKVF0J2 |
| 0.04% | TERN | TERNS PHARMACEUTICALS INC | -- | $24,343.77 | 3,117 | BMDJ0C9 |
| 0.04% | ARVN | ARVINAS INC | -- | $23,874.95 | 2,615 | BDZ30Q0 |
| 0.04% | CSTL | CASTLE BIOSCIENCES INC | -- | $23,779.66 | 1,033 | BKLCWZ3 |
| 0.04% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $23,701.82 | 2,866 | BFYQFJ2 |
| 0.04% | SIGA | SIGA TECHNOLOGIES INC | -- | $23,545.73 | 2,551 | 2107437 |
| 0.04% | ERAS | ERASCA INC | -- | $22,332.05 | 10,105 | BNLYBF3 |
| 0.04% | KROS | KEROS THERAPEUTICS INC | -- | $22,110.16 | 1,447 | BM7V485 |
| 0.04% | PSNL | PERSONALIS INC | -- | $21,828.69 | 3,159 | BJQ0608 |
| 0.04% | SVRA | SAVARA INC | -- | $21,795.78 | 6,157 | BYXGN81 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $21,605.65 | 1,793 | BD06CS0 |
| 0.03% | ESPR | ESPERION THERAPEUTICS INC | -- | $20,830.70 | 7,183 | BBNBTD2 |
| 0.03% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $19,804.16 | 967 | BKC9SX3 |
| 0.03% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $19,268.04 | 2,654 | BYP80F1 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $19,026.56 | 1,918 | B91XRN2 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $18,860.00 | 2,000 | BLFBZ32 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $18,850.59 | 3,267 | BMC3HS7 |
| 0.03% | LXRX | LEXICON PHARMACEUTICALS INC | -- | $18,253.86 | 12,946 | BWFZX59 |
| 0.03% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $17,994.24 | 639 | BQD3J33 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $17,870.40 | 510 | B292NQ7 |
| 0.03% | HCM | HUTCHMED CHINA-ADR | -- | $17,635.80 | 1,105 | BYXV9H7 |
| 0.03% | RGNX | REGENXBIO INC | -- | $17,586.00 | 1,800 | BZ0G875 |
| 0.03% | INBX | INHIBRX BIOSCIENCES INC | -- | $17,533.68 | 516 | BNSP8K3 |
| 0.03% | ABSI | ABSCI CORP | -- | $16,673.51 | 5,327 | BN94K69 |
| 0.03% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $16,500.00 | 2,200 | BP7KZP7 |
| 0.03% | SLDB | SOLID BIOSCIENCES INC | -- | $16,283.38 | 2,774 | BQHN6C7 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $16,183.56 | 5,154 | BMCWKZ2 |
| 0.02% | ATXS | ASTRIA THERAPEUTICS INC | -- | $15,155.40 | 2,010 | BMYRFN8 |
| 0.02% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $14,766.00 | 10,700 | B4N8MH9 |
| 0.02% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $14,526.72 | 1,664 | BKLXFX5 |
| 0.02% | EOLS | EVOLUS INC | -- | $14,169.60 | 2,304 | BDRJH21 |
| 0.02% | ALMS | ALUMIS INC | -- | $14,011.06 | 3,451 | BPLQG36 |
| 0.02% | DSGN | DESIGN THERAPEUTICS INC | -- | $13,776.91 | 2,029 | BMFK3H6 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $13,719.51 | 1,647 | BKDQKM6 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $13,609.95 | 2,213 | BP81R42 |
| 0.02% | LXEO | LEXEO THERAPEUTICS INC | -- | $12,775.36 | 1,924 | BQ6C357 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $12,653.35 | 3,049 | BMXNGZ6 |
| 0.02% | CGEM | CULLINAN THERAPEUTICS INC | -- | $12,624.00 | 2,104 | BM90J52 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $12,167.28 | 3,144 | BFY7DC4 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $12,147.04 | 3,844 | BDFKQ07 |
| 0.02% | TKNO | ALPHA TEKNOVA INC | -- | $12,141.22 | 1,906 | BP7L561 |
| 0.02% | AMRN | AMARIN CORP PLC -ADR | -- | $11,947.52 | 718 | BN72KB0 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $11,932.15 | 7,145 | BFMLGR4 |
| 0.02% | ANNX | ANNEXON INC | -- | $11,862.45 | 3,915 | BMVV9R5 |
| 0.02% | REPL | REPLIMUNE GROUP INC | -- | $11,708.01 | 2,781 | BDDVW37 |
| 0.02% | EDIT | EDITAS MEDICINE INC | -- | $11,370.65 | 3,203 | BZ8FPH3 |
| 0.02% | LYEL | LYELL IMMUNOPHARMA INC | -- | $11,320.20 | 684 | BTNMG41 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $10,874.08 | 3,577 | BZC0D70 |
| 0.02% | ALEC | ALECTOR INC | -- | $10,818.00 | 3,606 | BJ4LDC4 |
| 0.02% | SCPH | SCPHARMACEUTICALS INC | -- | $10,748.34 | 1,899 | BYX2Z16 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $10,735.50 | 2,105 | B12W3P6 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $10,445.22 | 667 | BPBPCG8 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $10,268.82 | 5,769 | BN4JN37 |
| 0.02% | OMER | OMEROS CORP | -- | $10,035.36 | 2,424 | B4NB858 |
| 0.02% | HUMA | HUMACYTE INC | -- | $9,929.92 | 5,642 | BMYTJP4 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $9,929.02 | 2,014 | BMF7DT9 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $9,800.96 | 7,904 | BFZNYB7 |
| 0.02% | RNAC | CARTESIAN THERAPEUTICS INC | -- | $9,482.24 | 926 | BQB9HM8 |
| 0.02% | VYGR | VOYAGER THERAPEUTICS INC | -- | $9,247.68 | 1,976 | BY7RB53 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $9,199.77 | 1,541 | BSMLR16 |
| 0.02% | NGNE | NEUROGENE INC | -- | $9,131.30 | 508 | BS2F741 |
| 0.01% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $8,532.30 | 1,673 | BL5B6Z1 |
| 0.01% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $8,449.02 | 5,787 | B3MZ6K5 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $8,141.76 | 2,827 | BLN9Z50 |
| 0.01% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $8,084.82 | 762 | B9L5200 |
| 0.01% | CDXS | CODEXIS INC | -- | $8,040.00 | 3,216 | B5LL2C2 |
| 0.01% | TRDA | ENTRADA THERAPEUTICS INC | -- | $7,967.40 | 1,355 | BP81RK8 |
| 0.01% | OABI | OMNIAB INC | -- | $7,037.31 | 4,371 | BN13S71 |
| 0.01% | MXCT | MAXCYTE INC | -- | $6,076.80 | 3,798 | BKMQF66 |
| 0.01% | TVGN | TEVOGEN BIO HOLDINGS INC | -- | $5,584.58 | 7,007 | BPG5P75 |
| 0.01% | PEPG | PEPGEN INC | -- | $5,501.28 | 1,168 | BMTX3D7 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $5,450.25 | 2,535 | BKX9NQ0 |
| 0.01% | NKTX | NKARTA INC | -- | $5,388.90 | 2,530 | BK80YJ8 |
| 0.01% | FATE | FATE THERAPEUTICS INC | -- | $5,135.00 | 4,108 | BCZS820 |
| 0.01% | PYXS | PYXIS ONCOLOGY INC | -- | $4,837.71 | 2,209 | BLBR8D5 |
| 0.01% | CLYM | CLIMB BIO INC | -- | $4,755.58 | 2,414 | BMW5LX6 |
| 0.01% | BMEA | BIOMEA FUSION INC | -- | $4,430.80 | 2,120 | BNKF6N0 |
| 0.01% | TCRX | TSCAN THERAPEUTICS INC | -- | $3,906.21 | 1,869 | BNLYBJ7 |
| 0.01% | MGNX | MACROGENICS INC | -- | $3,828.40 | 2,252 | BFDV8K0 |
| 0.01% | APLT | APPLIED THERAPEUTICS INC | -- | $3,591.51 | 5,130 | BJL38Z1 |
| 0.01% | PLRX | PLIANT THERAPEUTICS INC | -- | $3,171.15 | 2,187 | BMDWW66 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $2,727.06 | 3,020 | BF12XC2 |
| -- | ARTV | ARTIVA BIOTHERAPEUTICS INC | -- | $2,540.40 | 870 | BMF1LJ7 |
| -- | ACRV | ACRIVON THERAPEUTICS INC | -- | $2,029.01 | 1,121 | BP2TPK4 |
| -- | MRSN | MERSANA THERAPEUTICS INC | -- | $1,413.32 | 178 | BVPKH99 |
| -- | OKUR | ONKURE THERAPEUTICS INC-A | -- | $1,222.86 | 458 | BT7KGT6 |
| -- | QTTB | Q32 BIO INC | -- | $904.80 | 435 | BS2FKQ4 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 30.28% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 18,402,232 | -- | 3,675 | -- |
| 25.10% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 15,257,578 | -- | 3,047 | -- |
| 22.94% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 13,940,629 | -- | 2,784 | -- |
| 20.68% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 12,568,599 | -- | 2,510 | -- |
| 20.47% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 12,438,406 | -- | 2,484 | -- |
| 15.81% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 9,609,220 | -- | 1,919 | -- |
| -- | -- | TREASURY BILL | -- | $4,996,079.05 | 5,000,000 | BRF3QJ3 |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $16,379,695.45 | 16,379,695 | -- |
Index
as of 6/30/2025
- Total Number of Companies260
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$5.68 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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