BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 9/30/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 11/10/2025- NAV $71.31
- NAV Change $+1.75
- Market Price $71.45
- Market Price Change $+1.92
- Trading Volume (M) 29,877
- 30-Day Median Bid Ask Spread 0.29%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 11/10/2025- NAV $71.31
- NAV Change $+1.75
- Market Price $71.45
- Market Price Change $+1.92
- Trading Volume (M) 29,877
- 30-Day Median Bid Ask Spread 0.29%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 11/10/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.21% | AMGN | AMGEN INC | -- | $3,640,527.68 | 11,248 | 2023607 |
| 4.99% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $3,485,851.20 | 8,276 | 2931034 |
| 4.84% | GILD | GILEAD SCIENCES INC | -- | $3,384,643.05 | 28,647 | 2369174 |
| 3.79% | REGN | REGENERON PHARMACEUTICALS | -- | $2,645,149.60 | 4,040 | 2730190 |
| 3.21% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,245,602.80 | 5,084 | B00FWN1 |
| 2.54% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $1,771,732.44 | 20,253 | 2989044 |
| 2.27% | INSM | INSMED INC | -- | $1,586,410.72 | 8,266 | 2614487 |
| 1.49% | ARGX | ARGENX SE - ADR | -- | $1,041,186.51 | 1,197 | BDVLM39 |
| 1.28% | BIIB | BIOGEN INC | -- | $895,994.84 | 5,734 | 2455965 |
| 1.16% | INCY | INCYTE CORP | -- | $809,369.26 | 7,637 | 2471950 |
| 1.15% | UTHR | UNITED THERAPEUTICS CORP | -- | $803,002.17 | 1,769 | 2430412 |
| 1.05% | ILMN | ILLUMINA INC | -- | $731,658.92 | 6,011 | 2613990 |
| 0.94% | MEDP | MEDPACE HOLDINGS INC | -- | $659,883.56 | 1,099 | BDCBC61 |
| 0.93% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $651,557.24 | 16,906 | BMVP7Y0 |
| 0.83% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $581,927.58 | 3,879 | 2623911 |
| 0.81% | ROIV | ROIVANT SCIENCES LTD | -- | $565,366.02 | 26,706 | BMW4NZ9 |
| 0.76% | SMMT | SUMMIT THERAPEUTICS INC | -- | $531,633.30 | 29,051 | BMTVQS7 |
| 0.76% | SNY | SANOFI-ADR | -- | $531,575.38 | 10,493 | 2964557 |
| 0.68% | GH | GUARDANT HEALTH INC | -- | $477,555.84 | 4,877 | BFXC911 |
| 0.68% | TEM | TEMPUS AI INC | -- | $473,532.66 | 6,597 | BSLSJJ0 |
| 0.67% | BBIO | BRIDGEBIO PHARMA INC | -- | $469,567.56 | 7,476 | BK1KWG8 |
| 0.67% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $466,503.80 | 2,380 | BV9G6B8 |
| 0.66% | VTRS | VIATRIS INC | -- | $463,690.98 | 45,594 | BMWS3X9 |
| 0.66% | RVMD | REVOLUTION MEDICINES INC | -- | $458,556.30 | 7,310 | BL71K91 |
| 0.62% | EXEL | EXELIXIS INC | -- | $435,964.48 | 10,528 | 2576941 |
| 0.62% | IONS | IONIS PHARMACEUTICALS INC | -- | $433,442.82 | 6,233 | BDJ0LS6 |
| 0.62% | ONC | BEONE MEDICINES LTD-ADR | -- | $432,898.00 | 1,315 | BYYWPW6 |
| 0.62% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $432,407.36 | 872 | BD59BS7 |
| 0.59% | BNTX | BIONTECH SE-ADR | -- | $413,345.38 | 3,934 | BK6H543 |
| 0.57% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $395,499.03 | 7,509 | 2437071 |
| 0.54% | MRNA | MODERNA INC | -- | $376,748.16 | 15,216 | BGSXTS3 |
| 0.50% | RNA | AVIDITY BIOSCIENCES INC | -- | $351,365.04 | 5,031 | BMWHPY1 |
| 0.45% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $315,926.68 | 2,372 | B4Q5ZN4 |
| 0.45% | HALO | HALOZYME THERAPEUTICS INC | -- | $311,077.74 | 4,574 | 2975098 |
| 0.42% | CYTK | CYTOKINETICS INC | -- | $291,033.80 | 4,679 | BBBSBJ5 |
| 0.40% | MRUS | MERUS NV | -- | $282,252.36 | 2,958 | BZBY005 |
| 0.38% | AXSM | AXSOME THERAPEUTICS INC | -- | $268,985.60 | 1,952 | BYZR4X4 |
| 0.36% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $253,642.74 | 2,598 | BF2YWG4 |
| 0.35% | NUVL | NUVALENT INC-A | -- | $242,398.86 | 2,607 | BMVBZD3 |
| 0.32% | KRYS | KRYSTAL BIOTECH INC | -- | $225,867.96 | 1,132 | BD6JX35 |
| 0.32% | PTCT | PTC THERAPEUTICS INC | -- | $225,195.36 | 3,107 | B17VCN9 |
| 0.31% | PCVX | VAXCYTE INC | -- | $217,861.92 | 5,076 | BKPVGH6 |
| 0.31% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $215,468.95 | 5,407 | BYQBFJ8 |
| 0.30% | ALKS | ALKERMES PLC | -- | $210,788.40 | 6,456 | B3P6D26 |
| 0.29% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $202,498.59 | 2,433 | BDCBCD8 |
| 0.28% | CRSP | CRISPR THERAPEUTICS AG | -- | $194,141.06 | 3,557 | BDHF4K6 |
| 0.27% | ACLX | ARCELLX INC | -- | $185,861.61 | 2,169 | BPCJ1Q2 |
| 0.25% | COGT | COGENT BIOSCIENCES INC | -- | $177,328.98 | 5,463 | BLR6XK8 |
| 0.25% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $171,662.85 | 4,405 | BP8JSP4 |
| 0.25% | KYMR | KYMERA THERAPEUTICS INC | -- | $171,282.96 | 2,796 | BMPRZV5 |
| 0.24% | AKRO | AKERO THERAPEUTICS INC | -- | $169,349.92 | 3,128 | BK7Y2V9 |
| 0.23% | LGND | LIGAND PHARMACEUTICALS | -- | $160,316.14 | 766 | 2501578 |
| 0.23% | IMVT | IMMUNOVANT INC | -- | $159,313.29 | 6,817 | BJRFSB7 |
| 0.22% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $152,660.35 | 3,683 | BDD19F8 |
| 0.22% | INDV | INDIVIOR PLC | -- | $150,663.52 | 4,879 | BP0BQQ5 |
| 0.21% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $146,475.60 | 6,598 | 2713317 |
| 0.20% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $141,008.84 | 12,283 | BFNF1D6 |
| 0.20% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $138,173.47 | 823 | BQ721R4 |
| 0.20% | ADMA | ADMA BIOLOGICS INC | -- | $137,273.72 | 9,332 | B9NSBM2 |
| 0.20% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $136,980.15 | 1,965 | BJDX8Y8 |
| 0.19% | VCYT | VERACYTE INC | -- | $130,310.95 | 3,077 | BFTWZY0 |
| 0.17% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $120,381.86 | 3,769 | BJ62Z18 |
| 0.17% | TARS | TARSUS PHARMACEUTICALS INC | -- | $120,176.29 | 1,651 | BMH5RL1 |
| 0.17% | GRAL | GRAIL INC | -- | $120,005.10 | 1,410 | BSLSSX7 |
| 0.17% | CGON | CG ONCOLOGY INC | -- | $119,936.04 | 2,982 | BRBCSP4 |
| 0.17% | TVTX | TRAVERE THERAPEUTICS INC | -- | $119,848.68 | 3,486 | BLFGJD5 |
| 0.17% | XENE | XENON PHARMACEUTICALS INC | -- | $115,806.15 | 3,015 | BRJ3GY4 |
| 0.17% | MLYS | MINERALYS THERAPEUTICS INC | -- | $115,388.50 | 2,593 | BP9N0G0 |
| 0.16% | IRON | DISC MEDICINE INC | -- | $113,668.80 | 1,360 | BMGJZJ8 |
| 0.16% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $111,363.75 | 4,689 | BKX9VD3 |
| 0.16% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $110,401.83 | 3,759 | BFZQ0L8 |
| 0.16% | FOLD | AMICUS THERAPEUTICS INC | -- | $108,486.00 | 12,054 | B19FQ48 |
| 0.15% | IDYA | IDEAYA BIOSCIENCES INC | -- | $105,890.92 | 3,428 | BK0VHF6 |
| 0.15% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $104,025.87 | 3,293 | BMX9K07 |
| 0.15% | DYN | DYNE THERAPEUTICS INC | -- | $102,989.64 | 5,564 | BN15WD1 |
| 0.15% | APGE | APOGEE THERAPEUTICS INC | -- | $102,356.31 | 1,803 | BM9HHL5 |
| 0.14% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $99,562.20 | 2,193 | B72ZBG4 |
| 0.13% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $94,015.36 | 2,272 | BCBVTX1 |
| 0.13% | APLS | APELLIS PHARMACEUTICALS INC | -- | $93,841.00 | 4,939 | BYTQ6X1 |
| 0.13% | DNLI | DENALI THERAPEUTICS INC | -- | $89,200.80 | 5,718 | BD2B4V0 |
| 0.13% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $87,598.05 | 5,955 | BJ5FZ74 |
| 0.12% | BEAM | BEAM THERAPEUTICS INC | -- | $85,647.40 | 3,956 | BK6L288 |
| 0.12% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $83,782.16 | 3,752 | BLB0YQ9 |
| 0.11% | IBRX | IMMUNITYBIO INC | -- | $79,848.72 | 36,967 | BNSP0B8 |
| 0.11% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $78,987.00 | 2,330 | BQS9486 |
| 0.11% | VCEL | VERICEL CORP | -- | $76,927.27 | 1,973 | BSBMN89 |
| 0.11% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $76,653.72 | 5,148 | BFWLC09 |
| 0.11% | TXG | 10X GENOMICS INC-CLASS A | -- | $76,415.92 | 4,474 | BKS3RS7 |
| 0.11% | ANIP | ANI PHARMACEUTICALS INC | -- | $75,412.64 | 848 | BCDWBX6 |
| 0.11% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $75,366.61 | 16,711 | BM9FJ13 |
| 0.11% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $75,313.60 | 4,120 | BKY5JZ8 |
| 0.11% | OCUL | OCULAR THERAPEUTIX INC | -- | $73,698.15 | 6,805 | BNZB1X8 |
| 0.10% | TWST | TWIST BIOSCIENCE CORP | -- | $73,096.56 | 2,361 | BGKG6G7 |
| 0.10% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $71,595.00 | 2,250 | BKSGZN7 |
| 0.10% | AVDL | AVADEL PHARMACEUTICALS | -- | $71,003.90 | 3,797 | BDGMC59 |
| 0.10% | VERA | VERA THERAPEUTICS INC | -- | $69,264.00 | 2,496 | BL55460 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $67,150.00 | 1,700 | BRXB0C0 |
| 0.10% | ALVO | ALVOTECH SA | -- | $67,080.68 | 12,241 | BPNTJ34 |
| 0.09% | SRPT | SAREPTA THERAPEUTICS INC | -- | $65,988.67 | 3,821 | B8DPDT7 |
| 0.09% | TERN | TERNS PHARMACEUTICALS INC | -- | $65,428.64 | 3,422 | BMDJ0C9 |
| 0.09% | MNKD | MANNKIND CORP | -- | $65,034.58 | 11,999 | BF081J4 |
| 0.09% | JANX | JANUX THERAPEUTICS INC | -- | $64,836.50 | 2,350 | BMFX8Y7 |
| 0.08% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $59,104.80 | 8,209 | 2100362 |
| 0.08% | QURE | UNIQURE NV | -- | $56,248.65 | 2,151 | BJFSR88 |
| 0.08% | TRVI | TREVI THERAPEUTICS INC | -- | $55,572.54 | 4,762 | BJH9ZN0 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $54,810.00 | 1,566 | BLCD809 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $53,628.96 | 1,232 | BX7RSN3 |
| 0.08% | ARDX | ARDELYX INC | -- | $53,245.60 | 9,424 | BN89V40 |
| 0.08% | ZYME | ZYMEWORKS INC | -- | $53,067.00 | 2,940 | BPCQZY9 |
| 0.08% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $52,960.68 | 3,369 | BN7Q7R7 |
| 0.07% | SYRE | SPYRE THERAPEUTICS INC | -- | $52,389.16 | 2,362 | BQBBDY8 |
| 0.07% | INVA | INNOVIVA INC | -- | $51,444.55 | 2,465 | BDDXF67 |
| 0.07% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $50,629.44 | 4,586 | BRJZSK0 |
| 0.07% | HROW | HARROW INC | -- | $49,400.58 | 1,447 | BHNDW86 |
| 0.07% | NVCR | NOVOCURE LTD | -- | $49,272.44 | 4,372 | BYSS4X4 |
| 0.07% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $48,751.80 | 6,315 | BLR7H87 |
| 0.07% | STOK | STOKE THERAPEUTICS INC | -- | $47,938.91 | 2,143 | BJQ05Z6 |
| 0.07% | GMAB | GENMAB A/S -SP ADR | -- | $47,658.40 | 1,640 | BBC9WC7 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $47,460.04 | 1,817 | BNFWZS4 |
| 0.07% | ORIC | ORIC PHARMACEUTICALS INC | -- | $47,323.08 | 3,798 | BKVDFF7 |
| 0.07% | ABCL | ABCELLERA BIOLOGICS INC | -- | $47,098.61 | 11,687 | BL53SR3 |
| 0.07% | PGEN | PRECIGEN INC | -- | $46,612.00 | 11,653 | BKM5C84 |
| 0.07% | CVAC | CUREVAC NV | -- | $46,050.15 | 8,805 | BN4RD42 |
| 0.06% | NVAX | NOVAVAX INC | -- | $45,162.72 | 6,352 | BJDQXG4 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $44,714.00 | 566 | BNSP8K3 |
| 0.06% | WVE | WAVE LIFE SCIENCES LTD | -- | $43,879.20 | 6,224 | BYZG9R0 |
| 0.06% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $43,351.07 | 2,317 | BMFD115 |
| 0.06% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $42,471.66 | 3,487 | BPCK358 |
| 0.06% | URGN | UROGEN PHARMA LTD | -- | $41,842.17 | 1,809 | BZ7PJQ1 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $41,682.04 | 10,117 | BMFJJ97 |
| 0.06% | RLAY | RELAY THERAPEUTICS INC | -- | $41,604.31 | 6,743 | BN2R582 |
| 0.06% | TSHA | TAYSHA GENE THERAPIES INC | -- | $41,498.52 | 10,668 | BNC1BX1 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $41,030.60 | 4,771 | B8K7T65 |
| 0.06% | ZLAB | ZAI LAB LTD-ADR | -- | $40,934.30 | 1,870 | BD9GVY0 |
| 0.06% | ORKA | ORUKA THERAPEUTICS INC | -- | $40,933.44 | 1,464 | BKVF0J2 |
| 0.06% | NTLA | INTELLIA THERAPEUTICS INC | -- | $40,846.54 | 4,198 | BYZM6C2 |
| 0.06% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $40,700.96 | 4,006 | BLB0YH0 |
| 0.06% | PCRX | PACIRA BIOSCIENCES INC | -- | $40,533.99 | 1,757 | B3X26D8 |
| 0.06% | FTRE | FORTREA HOLDINGS INC | -- | $39,700.18 | 3,551 | BRXYZ57 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $39,395.16 | 1,134 | BKLCWZ3 |
| 0.05% | XNCR | XENCOR INC | -- | $38,320.86 | 2,789 | BGCYWN8 |
| 0.05% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $38,087.02 | 2,774 | BJLKVS6 |
| 0.05% | ANAB | ANAPTYSBIO INC | -- | $37,208.10 | 1,095 | BDRW1L7 |
| 0.05% | NRIX | NURIX THERAPEUTICS INC | -- | $36,627.50 | 2,990 | BMVLGP2 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $36,526.51 | 797 | BL95N25 |
| 0.05% | RAPP | RAPPORT THERAPEUTICS INC | -- | $35,553.71 | 1,427 | BR3T9B6 |
| 0.05% | KURA | KURA ONCOLOGY INC | -- | $35,026.08 | 3,394 | BYZD465 |
| 0.05% | MNMD | MIND MEDICINE MINDMED INC | -- | $34,968.00 | 2,976 | BPQYY97 |
| 0.05% | TNGX | TANGO THERAPEUTICS INC | -- | $34,503.43 | 4,351 | BP2P6L0 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $34,411.23 | 7,497 | BZ0QMB7 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $34,321.20 | 3,865 | BMCR7V2 |
| 0.05% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $33,954.90 | 2,415 | BP7KZP7 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $33,537.87 | 14,151 | BF0DMK7 |
| 0.05% | CRMD | CORMEDIX INC | -- | $32,342.52 | 2,919 | BJ0LT31 |
| 0.05% | ARVN | ARVINAS INC | -- | $32,126.49 | 2,871 | BDZ30Q0 |
| 0.04% | EYPT | EYEPOINT PHARMACEUTICALS INC | -- | $30,622.30 | 2,698 | BMGS7L1 |
| 0.04% | TYRA | TYRA BIOSCIENCES INC | -- | $30,261.50 | 2,087 | BMVNDH9 |
| 0.04% | PSNL | PERSONALIS INC | -- | $29,928.84 | 3,468 | BJQ0608 |
| 0.04% | TBPH | THERAVANCE BIOPHARMA INC | -- | $29,707.60 | 1,970 | BMNDK09 |
| 0.04% | AVBP | ARRIVENT BIOPHARMA INC | -- | $29,518.20 | 1,587 | BMGTLY5 |
| 0.04% | VIR | VIR BIOTECHNOLOGY INC | -- | $29,175.21 | 5,433 | BK4PZ38 |
| 0.04% | GERN | GERON CORP | -- | $28,943.16 | 24,951 | 2370381 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $28,077.66 | 1,846 | BQS7491 |
| 0.04% | ATXS | ASTRIA THERAPEUTICS INC | -- | $27,830.27 | 2,207 | BMYRFN8 |
| 0.04% | KROS | KEROS THERAPEUTICS INC | -- | $27,059.52 | 1,588 | BM7V485 |
| 0.04% | SVRA | SAVARA INC | -- | $27,036.00 | 6,759 | BYXGN81 |
| 0.04% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $26,898.30 | 3,146 | BFYQFJ2 |
| 0.04% | REPL | REPLIMUNE GROUP INC | -- | $26,591.63 | 3,053 | BDDVW37 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $26,398.98 | 4,731 | BYVQJ96 |
| 0.04% | LENZ | LENZ THERAPEUTICS INC | -- | $25,856.85 | 1,115 | BQV0J03 |
| 0.04% | ERAS | ERASCA INC | -- | $25,405.26 | 11,094 | BNLYBF3 |
| 0.03% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $24,219.55 | 701 | BQD3J33 |
| 0.03% | PRME | PRIME MEDICINE INC | -- | $24,103.95 | 6,838 | BPBJFM7 |
| 0.03% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $23,350.80 | 2,684 | BMZ4LN0 |
| 0.03% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $23,049.74 | 2,914 | BYP80F1 |
| 0.03% | ESPR | ESPERION THERAPEUTICS INC | -- | $22,708.80 | 7,885 | BBNBTD2 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $22,165.65 | 2,105 | B91XRN2 |
| 0.03% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $21,799.91 | 3,359 | BYTYP72 |
| 0.03% | RGNX | REGENXBIO INC | -- | $21,764.50 | 1,975 | BZ0G875 |
| 0.03% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $21,442.41 | 1,969 | BD06CS0 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $20,674.72 | 11,747 | B4N8MH9 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $20,589.38 | 3,587 | BMC3HS7 |
| 0.03% | LXRX | LEXICON PHARMACEUTICALS INC | -- | $20,181.04 | 14,212 | BWFZX59 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $19,974.50 | 2,195 | BLFBZ32 |
| 0.03% | ABSI | ABSCI CORP | -- | $19,412.04 | 5,847 | BN94K69 |
| 0.03% | ALMS | ALUMIS INC | -- | $19,134.45 | 3,789 | BPLQG36 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $18,570.42 | 1,826 | BKLXFX5 |
| 0.03% | HCM | HUTCHMED CHINA-ADR | -- | $18,298.11 | 1,213 | BYXV9H7 |
| 0.03% | SIGA | SIGA TECHNOLOGIES INC | -- | $18,228.00 | 2,800 | 2107437 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $18,172.00 | 560 | B292NQ7 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $17,994.24 | 2,112 | BQ6C357 |
| 0.03% | EOLS | EVOLUS INC | -- | $17,836.50 | 2,530 | BDRJH21 |
| 0.03% | NMRA | NEUMORA THERAPEUTICS INC | -- | $17,795.73 | 6,333 | BN4JN37 |
| 0.03% | OMER | OMEROS CORP | -- | $17,562.60 | 2,661 | B4NB858 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $17,539.80 | 5,658 | BMCWKZ2 |
| 0.02% | CGEM | CULLINAN THERAPEUTICS INC | -- | $17,186.40 | 2,310 | BM90J52 |
| 0.02% | DSGN | DESIGN THERAPEUTICS INC | -- | $16,546.61 | 2,227 | BMFK3H6 |
| 0.02% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $16,070.56 | 6,352 | B3MZ6K5 |
| 0.02% | NGNE | NEUROGENE INC | -- | $15,791.40 | 558 | BS2F741 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $14,705.52 | 3,452 | BFY7DC4 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $13,820.16 | 732 | BPBPCG8 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $13,408.08 | 2,429 | BP81R42 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $13,293.00 | 4,220 | BDFKQ07 |
| 0.02% | LYEL | LYELL IMMUNOPHARMA INC | -- | $13,277.68 | 751 | BTNMG41 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $13,155.45 | 3,927 | BZC0D70 |
| 0.02% | ANNX | ANNEXON INC | -- | $12,805.06 | 4,297 | BMVV9R5 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $12,636.75 | 3,045 | BQHN6C7 |
| 0.02% | AMRN | AMARIN CORP PLC -ADR | -- | $12,489.80 | 788 | BN72KB0 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $11,896.64 | 1,808 | BKDQKM6 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $11,881.85 | 3,347 | BMXNGZ6 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $11,664.95 | 1,837 | BL5B6Z1 |
| 0.02% | PYXS | PYXIS ONCOLOGY INC | -- | $11,567.25 | 2,425 | BLBR8D5 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $10,805.49 | 1,691 | BSMLR16 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $10,802.88 | 1,488 | BP81RK8 |
| 0.01% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $10,354.08 | 7,844 | BFMLGR4 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $10,332.99 | 3,103 | BLN9Z50 |
| 0.01% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $10,238.86 | 8,677 | BFZNYB7 |
| 0.01% | VNDA | VANDA PHARMACEUTICALS INC | -- | $10,214.62 | 2,311 | B12W3P6 |
| 0.01% | FHTX | FOGHORN THERAPEUTICS INC | -- | $9,772.62 | 2,211 | BMF7DT9 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $9,648.73 | 2,093 | BP7L561 |
| 0.01% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $9,622.36 | 836 | B9L5200 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $9,324.36 | 1,062 | BKC9SX3 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $9,239.94 | 2,169 | BY7RB53 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $8,862.84 | 3,517 | BZ8FPH3 |
| 0.01% | HUMA | HUMACYTE INC | -- | $8,361.90 | 6,194 | BMYTJP4 |
| 0.01% | RNAC | CARTESIAN THERAPEUTICS INC | -- | $7,363.08 | 1,017 | BQB9HM8 |
| 0.01% | OABI | OMNIAB INC | -- | $7,150.51 | 4,799 | BN13S71 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $6,512.22 | 2,783 | BKX9NQ0 |
| 0.01% | CDXS | CODEXIS INC | -- | $6,177.50 | 3,530 | B5LL2C2 |
| 0.01% | MXCT | MAXCYTE INC | -- | $6,128.43 | 4,169 | BKMQF66 |
| 0.01% | PEPG | PEPGEN INC | -- | $5,465.58 | 1,283 | BMTX3D7 |
| 0.01% | NKTX | NKARTA INC | -- | $5,444.88 | 2,778 | BK80YJ8 |
| 0.01% | ALEC | ALECTOR INC | -- | $5,184.98 | 3,958 | BJ4LDC4 |
| 0.01% | FATE | FATE THERAPEUTICS INC | -- | $4,915.90 | 4,510 | BCZS820 |
| 0.01% | CLYM | CLIMB BIO INC | -- | $4,770.00 | 2,650 | BMW5LX6 |
| 0.01% | APLT | APPLIED THERAPEUTICS INC | -- | $4,717.44 | 5,616 | BJL38Z1 |
| 0.01% | PLRX | PLIANT THERAPEUTICS INC | -- | $3,889.62 | 2,401 | BMDWW66 |
| 0.01% | TVGN | TEVOGEN BIO HOLDINGS INC | -- | $3,691.87 | 7,693 | BPG5P75 |
| 0.01% | MGNX | MACROGENICS INC | -- | $3,534.96 | 2,472 | BFDV8K0 |
| 0.01% | ARTV | ARTIVA BIOTHERAPEUTICS INC | -- | $3,495.30 | 955 | BMF1LJ7 |
| -- | BMEA | BIOMEA FUSION INC | -- | $3,187.99 | 2,327 | BNKF6N0 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $2,672.22 | 3,315 | BF12XC2 |
| -- | ACRV | ACRIVON THERAPEUTICS INC | -- | $2,496.90 | 1,230 | BP2TPK4 |
| -- | TCRX | TSCAN THERAPEUTICS INC | -- | $2,236.68 | 2,052 | BNLYBJ7 |
| -- | MRSN | MERSANA THERAPEUTICS INC | -- | $1,678.95 | 195 | BVPKH99 |
| -- | OKUR | ONKURE THERAPEUTICS INC-A | -- | $1,541.14 | 502 | BT7KGT6 |
| -- | QTTB | Q32 BIO INC | -- | $1,159.11 | 477 | BS2FKQ4 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| 36.37% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 25,415,900 | -- | 4,737 | -- |
| 28.98% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 20,254,385 | -- | 3,775 | -- |
| 23.61% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 16,498,605 | -- | 3,075 | -- |
| 19.07% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 13,327,654 | -- | 2,484 | -- |
| 17.65% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 12,335,055 | -- | 2,299 | -- |
| 8.87% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 6,197,037 | -- | 1,155 | -- |
| -- | -- | TREASURY BILL | -- | $4,995,741.95 | 5,000,000 | BMGHP58 |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $19,066,263.18 | 19,066,263 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
Read More