BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 9/30/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 11/11/2025- NAV $75.50
- NAV Change $+4.19
- Market Price $75.40
- Market Price Change $+3.95
- Trading Volume (M) 30,293
- 30-Day Median Bid Ask Spread 0.29%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 11/11/2025- NAV $75.50
- NAV Change $+4.19
- Market Price $75.40
- Market Price Change $+3.95
- Trading Volume (M) 30,293
- 30-Day Median Bid Ask Spread 0.29%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 11/11/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.20% | AMGN | AMGEN INC | -- | $3,923,312.40 | 11,592 | 2023607 |
| 4.85% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $3,661,246.60 | 8,530 | 2931034 |
| 4.79% | GILD | GILEAD SCIENCES INC | -- | $3,618,584.00 | 29,525 | 2369174 |
| 3.72% | REGN | REGENERON PHARMACEUTICALS | -- | $2,808,826.20 | 4,164 | 2730190 |
| 3.14% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,368,218.00 | 5,240 | B00FWN1 |
| 2.46% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $1,859,575.57 | 20,873 | 2989044 |
| 2.19% | INSM | INSMED INC | -- | $1,650,238.80 | 8,520 | 2614487 |
| 1.45% | ARGX | ARGENX SE - ADR | -- | $1,096,926.12 | 1,233 | BDVLM39 |
| 1.25% | BIIB | BIOGEN INC | -- | $942,999.60 | 5,910 | 2455965 |
| 1.13% | INCY | INCYTE CORP | -- | $851,327.36 | 7,871 | 2471950 |
| 1.11% | UTHR | UNITED THERAPEUTICS CORP | -- | $837,139.83 | 1,823 | 2430412 |
| 1.01% | ILMN | ILLUMINA INC | -- | $759,507.00 | 6,195 | 2613990 |
| 0.90% | MEDP | MEDPACE HOLDINGS INC | -- | $682,938.41 | 1,133 | BDCBC61 |
| 0.90% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $678,839.04 | 17,424 | BMVP7Y0 |
| 0.78% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $588,718.13 | 3,997 | 2623911 |
| 0.76% | ROIV | ROIVANT SCIENCES LTD | -- | $575,251.60 | 27,524 | BMW4NZ9 |
| 0.76% | SMMT | SUMMIT THERAPEUTICS INC | -- | $573,669.56 | 29,941 | BMTVQS7 |
| 0.74% | SNY | SANOFI-ADR | -- | $559,027.35 | 10,815 | 2964557 |
| 0.70% | VTRS | VIATRIS INC | -- | $526,288.00 | 46,990 | BMWS3X9 |
| 0.68% | BBIO | BRIDGEBIO PHARMA INC | -- | $512,932.32 | 7,704 | BK1KWG8 |
| 0.65% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $493,244.32 | 2,452 | BV9G6B8 |
| 0.65% | GH | GUARDANT HEALTH INC | -- | $491,188.17 | 5,027 | BFXC911 |
| 0.64% | TEM | TEMPUS AI INC | -- | $486,536.44 | 6,799 | BSLSJJ0 |
| 0.64% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $486,267.00 | 898 | BD59BS7 |
| 0.64% | RVMD | REVOLUTION MEDICINES INC | -- | $482,778.72 | 7,534 | BL71K91 |
| 0.62% | EXEL | EXELIXIS INC | -- | $466,278.75 | 10,850 | 2576941 |
| 0.62% | ONC | BEONE MEDICINES LTD-ADR | -- | $465,645.75 | 1,355 | BYYWPW6 |
| 0.62% | IONS | IONIS PHARMACEUTICALS INC | -- | $465,346.35 | 6,423 | BDJ0LS6 |
| 0.58% | BNTX | BIONTECH SE-ADR | -- | $440,467.10 | 4,054 | BK6H543 |
| 0.56% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $425,103.27 | 7,739 | 2437071 |
| 0.55% | MRNA | MODERNA INC | -- | $414,161.62 | 15,682 | BGSXTS3 |
| 0.49% | RNA | AVIDITY BIOSCIENCES INC | -- | $366,579.50 | 5,185 | BMWHPY1 |
| 0.44% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $335,096.84 | 2,444 | B4Q5ZN4 |
| 0.44% | HALO | HALOZYME THERAPEUTICS INC | -- | $330,592.82 | 4,714 | 2975098 |
| 0.42% | CYTK | CYTOKINETICS INC | -- | $320,729.50 | 4,823 | BBBSBJ5 |
| 0.39% | MRUS | MERUS NV | -- | $291,023.04 | 3,048 | BZBY005 |
| 0.37% | AXSM | AXSOME THERAPEUTICS INC | -- | $280,895.32 | 2,012 | BYZR4X4 |
| 0.35% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $267,425.08 | 2,678 | BF2YWG4 |
| 0.34% | NUVL | NUVALENT INC-A | -- | $258,368.49 | 2,687 | BMVBZD3 |
| 0.32% | PCVX | VAXCYTE INC | -- | $238,893.12 | 5,232 | BKPVGH6 |
| 0.31% | KRYS | KRYSTAL BIOTECH INC | -- | $236,698.00 | 1,166 | BD6JX35 |
| 0.31% | PTCT | PTC THERAPEUTICS INC | -- | $236,445.46 | 3,203 | B17VCN9 |
| 0.31% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $231,279.50 | 5,573 | BYQBFJ8 |
| 0.30% | ALKS | ALKERMES PLC | -- | $224,971.74 | 6,654 | B3P6D26 |
| 0.28% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $214,498.92 | 2,507 | BDCBCD8 |
| 0.27% | CRSP | CRISPR THERAPEUTICS AG | -- | $202,344.65 | 3,665 | BDHF4K6 |
| 0.27% | ACLX | ARCELLX INC | -- | $201,664.05 | 2,235 | BPCJ1Q2 |
| 0.25% | COGT | COGENT BIOSCIENCES INC | -- | $188,188.02 | 5,631 | BLR6XK8 |
| 0.24% | KYMR | KYMERA THERAPEUTICS INC | -- | $182,632.34 | 2,882 | BMPRZV5 |
| 0.24% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $181,060.71 | 4,539 | BP8JSP4 |
| 0.23% | AKRO | AKERO THERAPEUTICS INC | -- | $174,902.00 | 3,224 | BK7Y2V9 |
| 0.22% | LGND | LIGAND PHARMACEUTICALS | -- | $164,873.00 | 790 | 2501578 |
| 0.22% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $162,957.30 | 3,795 | BDD19F8 |
| 0.21% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $161,296.00 | 6,800 | 2713317 |
| 0.21% | IMVT | IMMUNOVANT INC | -- | $160,802.25 | 7,025 | BJRFSB7 |
| 0.21% | INDV | INDIVIOR PLC | -- | $156,251.03 | 5,029 | BP0BQQ5 |
| 0.21% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $155,842.44 | 849 | BQ721R4 |
| 0.20% | ADMA | ADMA BIOLOGICS INC | -- | $154,176.54 | 9,618 | B9NSBM2 |
| 0.20% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $151,275.05 | 12,659 | BFNF1D6 |
| 0.19% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $144,423.00 | 2,025 | BJDX8Y8 |
| 0.18% | VCYT | VERACYTE INC | -- | $135,274.86 | 3,171 | BFTWZY0 |
| 0.17% | TVTX | TRAVERE THERAPEUTICS INC | -- | $129,707.12 | 3,592 | BLFGJD5 |
| 0.17% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $129,176.25 | 3,885 | BJ62Z18 |
| 0.17% | TARS | TARSUS PHARMACEUTICALS INC | -- | $128,663.64 | 1,701 | BMH5RL1 |
| 0.17% | MLYS | MINERALYS THERAPEUTICS INC | -- | $125,925.03 | 2,673 | BP9N0G0 |
| 0.16% | XENE | XENON PHARMACEUTICALS INC | -- | $124,031.44 | 3,107 | BRJ3GY4 |
| 0.16% | GRAL | GRAIL INC | -- | $121,249.06 | 1,454 | BSLSSX7 |
| 0.16% | IRON | DISC MEDICINE INC | -- | $120,670.14 | 1,402 | BMGJZJ8 |
| 0.16% | CGON | CG ONCOLOGY INC | -- | $119,394.16 | 3,074 | BRBCSP4 |
| 0.16% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $119,311.25 | 3,875 | BFZQ0L8 |
| 0.15% | APGE | APOGEE THERAPEUTICS INC | -- | $117,024.05 | 1,859 | BM9HHL5 |
| 0.15% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $116,136.99 | 4,833 | BKX9VD3 |
| 0.15% | FOLD | AMICUS THERAPEUTICS INC | -- | $115,791.68 | 12,424 | B19FQ48 |
| 0.15% | IDYA | IDEAYA BIOSCIENCES INC | -- | $113,059.32 | 3,532 | BK0VHF6 |
| 0.15% | DYN | DYNE THERAPEUTICS INC | -- | $112,787.78 | 5,734 | BN15WD1 |
| 0.14% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $108,677.79 | 3,393 | BMX9K07 |
| 0.14% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $104,254.71 | 2,261 | B72ZBG4 |
| 0.14% | DNLI | DENALI THERAPEUTICS INC | -- | $103,616.52 | 5,894 | BD2B4V0 |
| 0.14% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $102,720.12 | 2,342 | BCBVTX1 |
| 0.13% | APLS | APELLIS PHARMACEUTICALS INC | -- | $99,325.41 | 5,091 | BYTQ6X1 |
| 0.12% | BEAM | BEAM THERAPEUTICS INC | -- | $91,673.44 | 4,078 | BK6L288 |
| 0.12% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $91,204.08 | 4,246 | BKY5JZ8 |
| 0.12% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $89,170.61 | 6,137 | BJ5FZ74 |
| 0.12% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $87,139.64 | 3,866 | BLB0YQ9 |
| 0.11% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $83,745.73 | 2,402 | BQS9486 |
| 0.11% | VCEL | VERICEL CORP | -- | $83,454.65 | 2,033 | BSBMN89 |
| 0.11% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $83,198.08 | 5,306 | BFWLC09 |
| 0.11% | IBRX | IMMUNITYBIO INC | -- | $81,531.86 | 38,099 | BNSP0B8 |
| 0.11% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $81,120.33 | 17,223 | BM9FJ13 |
| 0.10% | OCUL | OCULAR THERAPEUTIX INC | -- | $78,685.86 | 7,013 | BNZB1X8 |
| 0.10% | ANIP | ANI PHARMACEUTICALS INC | -- | $77,383.96 | 874 | BCDWBX6 |
| 0.10% | TXG | 10X GENOMICS INC-CLASS A | -- | $76,513.08 | 4,612 | BKS3RS7 |
| 0.10% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $76,447.64 | 2,318 | BKSGZN7 |
| 0.10% | VERA | VERA THERAPEUTICS INC | -- | $76,414.12 | 2,572 | BL55460 |
| 0.10% | TWST | TWIST BIOSCIENCE CORP | -- | $76,201.56 | 2,433 | BGKG6G7 |
| 0.10% | AVDL | AVADEL PHARMACEUTICALS | -- | $73,681.79 | 3,913 | BDGMC59 |
| 0.10% | TERN | TERNS PHARMACEUTICALS INC | -- | $72,565.08 | 3,526 | BMDJ0C9 |
| 0.09% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $71,078.64 | 1,752 | BRXB0C0 |
| 0.09% | SRPT | SAREPTA THERAPEUTICS INC | -- | $70,823.22 | 3,939 | B8DPDT7 |
| 0.09% | ALVO | ALVOTECH SA | -- | $70,391.70 | 12,615 | BPNTJ34 |
| 0.09% | JANX | JANUX THERAPEUTICS INC | -- | $69,923.14 | 2,422 | BMFX8Y7 |
| 0.09% | QURE | UNIQURE NV | -- | $68,372.28 | 2,217 | BJFSR88 |
| 0.09% | MNKD | MANNKIND CORP | -- | $64,926.75 | 12,367 | BF081J4 |
| 0.08% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $61,576.29 | 3,473 | BN7Q7R7 |
| 0.08% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $61,173.03 | 8,461 | 2100362 |
| 0.08% | ZYME | ZYMEWORKS INC | -- | $59,630.40 | 3,030 | BPCQZY9 |
| 0.08% | ARDX | ARDELYX INC | -- | $59,534.56 | 9,712 | BN89V40 |
| 0.08% | TRVI | TREVI THERAPEUTICS INC | -- | $59,386.80 | 4,908 | BJH9ZN0 |
| 0.08% | HROW | HARROW INC | -- | $57,761.34 | 1,491 | BHNDW86 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $56,946.80 | 1,270 | BX7RSN3 |
| 0.08% | SYRE | SPYRE THERAPEUTICS INC | -- | $56,833.90 | 2,434 | BQBBDY8 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $56,812.80 | 1,614 | BLCD809 |
| 0.07% | INVA | INNOVIVA INC | -- | $55,647.90 | 2,541 | BDDXF67 |
| 0.07% | STOK | STOKE THERAPEUTICS INC | -- | $55,467.99 | 2,209 | BJQ05Z6 |
| 0.07% | NVCR | NOVOCURE LTD | -- | $53,441.16 | 4,506 | BYSS4X4 |
| 0.07% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $53,262.02 | 4,726 | BRJZSK0 |
| 0.07% | GMAB | GENMAB A/S -SP ADR | -- | $51,223.90 | 1,690 | BBC9WC7 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $50,870.68 | 1,873 | BNFWZS4 |
| 0.07% | ORIC | ORIC PHARMACEUTICALS INC | -- | $50,412.32 | 3,914 | BKVDFF7 |
| 0.06% | NVAX | NOVAVAX INC | -- | $48,702.24 | 6,546 | BJDQXG4 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $48,426.96 | 6,509 | BLR7H87 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $48,300.45 | 12,045 | BL53SR3 |
| 0.06% | CVAC | CUREVAC NV | -- | $47,916.00 | 9,075 | BN4RD42 |
| 0.06% | PGEN | PRECIGEN INC | -- | $47,555.64 | 12,009 | BKM5C84 |
| 0.06% | TSHA | TAYSHA GENE THERAPIES INC | -- | $47,054.32 | 10,994 | BNC1BX1 |
| 0.06% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $46,880.68 | 2,387 | BMFD115 |
| 0.06% | WVE | WAVE LIFE SCIENCES LTD | -- | $46,565.64 | 6,414 | BYZG9R0 |
| 0.06% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $45,559.24 | 3,593 | BPCK358 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $45,458.56 | 584 | BNSP8K3 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $44,210.48 | 10,427 | BMFJJ97 |
| 0.06% | URGN | UROGEN PHARMA LTD | -- | $44,069.95 | 1,865 | BZ7PJQ1 |
| 0.06% | NTLA | INTELLIA THERAPEUTICS INC | -- | $44,038.68 | 4,326 | BYZM6C2 |
| 0.06% | RLAY | RELAY THERAPEUTICS INC | -- | $43,709.21 | 6,949 | BN2R582 |
| 0.06% | PCRX | PACIRA BIOSCIENCES INC | -- | $43,681.32 | 1,811 | B3X26D8 |
| 0.06% | FTRE | FORTREA HOLDINGS INC | -- | $43,139.61 | 3,659 | BRXYZ57 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $42,925.41 | 4,917 | B8K7T65 |
| 0.06% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $42,766.08 | 4,128 | BLB0YH0 |
| 0.06% | XNCR | XENCOR INC | -- | $42,751.25 | 2,875 | BGCYWN8 |
| 0.06% | ORKA | ORUKA THERAPEUTICS INC | -- | $42,525.60 | 1,508 | BKVF0J2 |
| 0.06% | ZLAB | ZAI LAB LTD-ADR | -- | $42,416.00 | 1,928 | BD9GVY0 |
| 0.05% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $41,040.88 | 2,858 | BJLKVS6 |
| 0.05% | CSTL | CASTLE BIOSCIENCES INC | -- | $40,844.96 | 1,168 | BKLCWZ3 |
| 0.05% | NRIX | NURIX THERAPEUTICS INC | -- | $39,634.52 | 3,082 | BMVLGP2 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $38,650.25 | 14,585 | BF0DMK7 |
| 0.05% | MNMD | MIND MEDICINE MINDMED INC | -- | $38,288.64 | 3,068 | BPQYY97 |
| 0.05% | ANAB | ANAPTYSBIO INC | -- | $37,889.24 | 1,129 | BDRW1L7 |
| 0.05% | TNGX | TANGO THERAPEUTICS INC | -- | $37,584.30 | 4,485 | BP2P6L0 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $37,555.00 | 2,030 | BMNDK09 |
| 0.05% | RAPP | RAPPORT THERAPEUTICS INC | -- | $37,510.50 | 1,471 | BR3T9B6 |
| 0.05% | KURA | KURA ONCOLOGY INC | -- | $37,393.62 | 3,498 | BYZD465 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $37,215.93 | 821 | BL95N25 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $36,394.17 | 7,727 | BZ0QMB7 |
| 0.05% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $35,642.48 | 2,489 | BP7KZP7 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $34,930.91 | 3,983 | BMCR7V2 |
| 0.04% | CRMD | CORMEDIX INC | -- | $33,670.71 | 3,009 | BJ0LT31 |
| 0.04% | ARVN | ARVINAS INC | -- | $33,170.39 | 2,959 | BDZ30Q0 |
| 0.04% | TYRA | TYRA BIOSCIENCES INC | -- | $32,544.63 | 2,151 | BMVNDH9 |
| 0.04% | EYPT | EYEPOINT PHARMACEUTICALS INC | -- | $32,373.10 | 2,780 | BMGS7L1 |
| 0.04% | GERN | GERON CORP | -- | $32,143.75 | 25,715 | 2370381 |
| 0.04% | VIR | VIR BIOTECHNOLOGY INC | -- | $31,970.29 | 5,599 | BK4PZ38 |
| 0.04% | AVBP | ARRIVENT BIOPHARMA INC | -- | $31,686.30 | 1,635 | BMGTLY5 |
| 0.04% | LENZ | LENZ THERAPEUTICS INC | -- | $30,391.05 | 1,149 | BQV0J03 |
| 0.04% | SVRA | SAVARA INC | -- | $30,167.11 | 6,967 | BYXGN81 |
| 0.04% | PSNL | PERSONALIS INC | -- | $30,164.56 | 3,574 | BJQ0608 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $29,538.06 | 1,902 | BQS7491 |
| 0.04% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $28,853.80 | 3,242 | BFYQFJ2 |
| 0.04% | REPL | REPLIMUNE GROUP INC | -- | $28,732.11 | 3,147 | BDDVW37 |
| 0.04% | ATXS | ASTRIA THERAPEUTICS INC | -- | $28,460.25 | 2,275 | BMYRFN8 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $27,738.75 | 4,875 | BYVQJ96 |
| 0.04% | KROS | KEROS THERAPEUTICS INC | -- | $27,648.40 | 1,636 | BM7V485 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $27,628.16 | 7,048 | BPBJFM7 |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $27,437.85 | 723 | BQD3J33 |
| 0.04% | ERAS | ERASCA INC | -- | $26,984.24 | 11,434 | BNLYBF3 |
| 0.03% | ESPR | ESPERION THERAPEUTICS INC | -- | $25,193.70 | 8,127 | BBNBTD2 |
| 0.03% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $24,542.68 | 3,004 | BYP80F1 |
| 0.03% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $23,707.85 | 3,461 | BYTYP72 |
| 0.03% | RGNX | REGENXBIO INC | -- | $23,504.25 | 2,035 | BZ0G875 |
| 0.03% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $23,272.63 | 2,029 | BD06CS0 |
| 0.03% | LXRX | LEXICON PHARMACEUTICALS INC | -- | $22,850.88 | 14,648 | BWFZX59 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $22,731.12 | 2,169 | B91XRN2 |
| 0.03% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $22,653.54 | 2,766 | BMZ4LN0 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $22,519.02 | 12,107 | B4N8MH9 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $21,340.09 | 2,263 | BLFBZ32 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $21,072.90 | 3,697 | BMC3HS7 |
| 0.03% | ABSI | ABSCI CORP | -- | $20,793.15 | 6,027 | BN94K69 |
| 0.03% | ALMS | ALUMIS INC | -- | $20,696.50 | 3,905 | BPLQG36 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $20,325.60 | 1,882 | BKLXFX5 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $19,845.12 | 2,176 | BQ6C357 |
| 0.03% | HCM | HUTCHMED CHINA-ADR | -- | $19,065.24 | 1,251 | BYXV9H7 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $18,987.30 | 578 | B292NQ7 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $18,954.00 | 5,832 | BMCWKZ2 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $18,917.94 | 6,546 | B3MZ6K5 |
| 0.03% | OMER | OMEROS CORP | -- | $18,899.27 | 2,743 | B4NB858 |
| 0.02% | CGEM | CULLINAN THERAPEUTICS INC | -- | $18,564.00 | 2,380 | BM90J52 |
| 0.02% | EOLS | EVOLUS INC | -- | $18,229.92 | 2,608 | BDRJH21 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $18,152.94 | 2,886 | 2107437 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $17,949.25 | 6,527 | BN4JN37 |
| 0.02% | DSGN | DESIGN THERAPEUTICS INC | -- | $17,809.20 | 2,295 | BMFK3H6 |
| 0.02% | NGNE | NEUROGENE INC | -- | $17,781.12 | 576 | BS2F741 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $15,228.24 | 3,558 | BFY7DC4 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $14,310.92 | 754 | BPBPCG8 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $14,219.67 | 3,139 | BQHN6C7 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $14,181.00 | 4,350 | BDFKQ07 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $14,166.98 | 2,503 | BP81R42 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $13,719.33 | 4,047 | BZC0D70 |
| 0.02% | LYEL | LYELL IMMUNOPHARMA INC | -- | $13,368.75 | 775 | BTNMG41 |
| 0.02% | ANNX | ANNEXON INC | -- | $13,154.13 | 4,429 | BMVV9R5 |
| 0.02% | AMRN | AMARIN CORP PLC -ADR | -- | $13,065.08 | 812 | BN72KB0 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $12,731.12 | 1,864 | BKDQKM6 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $12,720.96 | 1,893 | BL5B6Z1 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $12,519.87 | 3,449 | BMXNGZ6 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $12,201.00 | 1,743 | BSMLR16 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $12,126.00 | 8,084 | BFMLGR4 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $11,811.80 | 1,534 | BP81RK8 |
| 0.02% | PYXS | PYXIS ONCOLOGY INC | -- | $11,420.43 | 2,499 | BLBR8D5 |
| 0.01% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $11,089.32 | 8,943 | BFZNYB7 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $10,812.62 | 3,199 | BLN9Z50 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $10,569.30 | 2,157 | BP7L561 |
| 0.01% | VNDA | VANDA PHARMACEUTICALS INC | -- | $10,428.78 | 2,381 | B12W3P6 |
| 0.01% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $10,378.48 | 862 | B9L5200 |
| 0.01% | FHTX | FOGHORN THERAPEUTICS INC | -- | $10,118.76 | 2,279 | BMF7DT9 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $9,642.50 | 3,625 | BZ8FPH3 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $9,521.10 | 2,235 | BY7RB53 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $9,484.98 | 1,094 | BKC9SX3 |
| 0.01% | HUMA | HUMACYTE INC | -- | $8,171.52 | 6,384 | BMYTJP4 |
| 0.01% | OABI | OMNIAB INC | -- | $7,961.45 | 4,945 | BN13S71 |
| 0.01% | RNAC | CARTESIAN THERAPEUTICS INC | -- | $7,657.70 | 1,049 | BQB9HM8 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $7,115.12 | 2,869 | BKX9NQ0 |
| 0.01% | MXCT | MAXCYTE INC | -- | $6,660.35 | 4,297 | BKMQF66 |
| 0.01% | CDXS | CODEXIS INC | -- | $6,548.40 | 3,638 | B5LL2C2 |
| 0.01% | PEPG | PEPGEN INC | -- | $6,151.95 | 1,323 | BMTX3D7 |
| 0.01% | NKTX | NKARTA INC | -- | $5,756.64 | 2,864 | BK80YJ8 |
| 0.01% | ALEC | ALECTOR INC | -- | $5,548.80 | 4,080 | BJ4LDC4 |
| 0.01% | APLT | APPLIED THERAPEUTICS INC | -- | $5,325.54 | 5,788 | BJL38Z1 |
| 0.01% | FATE | FATE THERAPEUTICS INC | -- | $5,205.76 | 4,648 | BCZS820 |
| 0.01% | CLYM | CLIMB BIO INC | -- | $5,190.80 | 2,732 | BMW5LX6 |
| 0.01% | PLRX | PLIANT THERAPEUTICS INC | -- | $4,133.25 | 2,475 | BMDWW66 |
| 0.01% | MGNX | MACROGENICS INC | -- | $3,872.96 | 2,548 | BFDV8K0 |
| -- | TVGN | TEVOGEN BIO HOLDINGS INC | -- | $3,726.63 | 7,929 | BPG5P75 |
| -- | ARTV | ARTIVA BIOTHERAPEUTICS INC | -- | $3,536.15 | 985 | BMF1LJ7 |
| -- | BMEA | BIOMEA FUSION INC | -- | $3,358.60 | 2,399 | BNKF6N0 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $2,778.36 | 3,417 | BF12XC2 |
| -- | ACRV | ACRIVON THERAPEUTICS INC | -- | $2,624.76 | 1,268 | BP2TPK4 |
| -- | TCRX | TSCAN THERAPEUTICS INC | -- | $2,579.08 | 2,114 | BNLYBJ7 |
| -- | MRSN | MERSANA THERAPEUTICS INC | -- | $1,790.91 | 201 | BVPKH99 |
| -- | OKUR | ONKURE THERAPEUTICS INC-A | -- | $1,642.06 | 518 | BT7KGT6 |
| -- | QTTB | Q32 BIO INC | -- | $1,237.32 | 491 | BS2FKQ4 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 35.08% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 26,488,596 | -- | 4,796 | -- |
| 34.65% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 26,162,735 | -- | 4,737 | -- |
| 22.49% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 16,983,410 | -- | 3,075 | -- |
| 18.17% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 13,719,281 | -- | 2,484 | -- |
| 16.82% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 12,697,515 | -- | 2,299 | -- |
| 8.45% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 6,379,134 | -- | 1,155 | -- |
| -- | -- | TREASURY BILL | -- | $4,995,735.05 | 5,000,000 | BMGHP58 |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $21,896,049.11 | 21,896,049 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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