BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 9/30/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 11/12/2025- NAV $75.79
- NAV Change $+0.29
- Market Price $76.07
- Market Price Change $+0.67
- Trading Volume (M) 37,117
- 30-Day Median Bid Ask Spread 0.29%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 11/12/2025- NAV $75.79
- NAV Change $+0.29
- Market Price $76.07
- Market Price Change $+0.67
- Trading Volume (M) 37,117
- 30-Day Median Bid Ask Spread 0.29%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 11/12/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.17% | AMGN | AMGEN INC | -- | $3,955,997.92 | 11,764 | 2023607 |
| 4.91% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $3,758,782.83 | 8,657 | 2931034 |
| 4.83% | GILD | GILEAD SCIENCES INC | -- | $3,697,557.60 | 29,964 | 2369174 |
| 3.76% | REGN | REGENERON PHARMACEUTICALS | -- | $2,880,948.72 | 4,226 | 2730190 |
| 3.15% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,407,671.32 | 5,318 | B00FWN1 |
| 2.43% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $1,857,325.44 | 21,183 | 2989044 |
| 2.20% | INSM | INSMED INC | -- | $1,680,890.33 | 8,647 | 2614487 |
| 1.45% | ARGX | ARGENX SE - ADR | -- | $1,113,252.39 | 1,251 | BDVLM39 |
| 1.27% | BIIB | BIOGEN INC | -- | $968,557.04 | 5,998 | 2455965 |
| 1.13% | INCY | INCYTE CORP | -- | $864,780.88 | 7,988 | 2471950 |
| 1.12% | UTHR | UNITED THERAPEUTICS CORP | -- | $853,849.00 | 1,850 | 2430412 |
| 1.00% | ILMN | ILLUMINA INC | -- | $766,888.26 | 6,287 | 2613990 |
| 0.91% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $700,069.97 | 17,683 | BMVP7Y0 |
| 0.90% | MEDP | MEDPACE HOLDINGS INC | -- | $687,240.00 | 1,150 | BDCBC61 |
| 0.78% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $595,623.60 | 4,056 | 2623911 |
| 0.78% | ROIV | ROIVANT SCIENCES LTD | -- | $595,531.56 | 27,933 | BMW4NZ9 |
| 0.75% | SMMT | SUMMIT THERAPEUTICS INC | -- | $572,168.38 | 30,386 | BMTVQS7 |
| 0.74% | SNY | SANOFI-ADR | -- | $569,873.92 | 10,976 | 2964557 |
| 0.69% | VTRS | VIATRIS INC | -- | $525,044.88 | 47,688 | BMWS3X9 |
| 0.68% | ONC | BEONE MEDICINES LTD-ADR | -- | $519,021.25 | 1,375 | BYYWPW6 |
| 0.68% | BBIO | BRIDGEBIO PHARMA INC | -- | $517,707.96 | 7,818 | BK1KWG8 |
| 0.66% | RVMD | REVOLUTION MEDICINES INC | -- | $503,336.18 | 7,646 | BL71K91 |
| 0.65% | GH | GUARDANT HEALTH INC | -- | $499,179.68 | 5,102 | BFXC911 |
| 0.65% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $495,659.36 | 2,488 | BV9G6B8 |
| 0.64% | TEM | TEMPUS AI INC | -- | $490,590.00 | 6,900 | BSLSJJ0 |
| 0.63% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $481,864.34 | 911 | BD59BS7 |
| 0.63% | EXEL | EXELIXIS INC | -- | $479,969.49 | 11,011 | 2576941 |
| 0.62% | IONS | IONIS PHARMACEUTICALS INC | -- | $473,663.06 | 6,518 | BDJ0LS6 |
| 0.60% | BNTX | BIONTECH SE-ADR | -- | $459,533.80 | 4,114 | BK6H543 |
| 0.57% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $434,483.28 | 7,854 | 2437071 |
| 0.56% | MRNA | MODERNA INC | -- | $425,089.65 | 15,915 | BGSXTS3 |
| 0.49% | RNA | AVIDITY BIOSCIENCES INC | -- | $372,654.84 | 5,262 | BMWHPY1 |
| 0.44% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $339,040.80 | 2,480 | B4Q5ZN4 |
| 0.44% | HALO | HALOZYME THERAPEUTICS INC | -- | $337,893.92 | 4,784 | 2975098 |
| 0.42% | CYTK | CYTOKINETICS INC | -- | $322,776.30 | 4,895 | BBBSBJ5 |
| 0.39% | MRUS | MERUS NV | -- | $297,051.72 | 3,093 | BZBY005 |
| 0.38% | AXSM | AXSOME THERAPEUTICS INC | -- | $287,636.12 | 2,042 | BYZR4X4 |
| 0.35% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $266,146.56 | 2,718 | BF2YWG4 |
| 0.35% | NUVL | NUVALENT INC-A | -- | $264,600.81 | 2,727 | BMVBZD3 |
| 0.32% | PCVX | VAXCYTE INC | -- | $244,791.00 | 5,310 | BKPVGH6 |
| 0.32% | PTCT | PTC THERAPEUTICS INC | -- | $243,662.45 | 3,251 | B17VCN9 |
| 0.31% | KRYS | KRYSTAL BIOTECH INC | -- | $240,184.49 | 1,183 | BD6JX35 |
| 0.31% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $234,271.52 | 5,656 | BYQBFJ8 |
| 0.28% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $215,858.40 | 2,544 | BDCBCD8 |
| 0.28% | ALKS | ALKERMES PLC | -- | $212,077.97 | 6,753 | B3P6D26 |
| 0.27% | ACLX | ARCELLX INC | -- | $204,448.86 | 2,268 | BPCJ1Q2 |
| 0.26% | COGT | COGENT BIOSCIENCES INC | -- | $201,510.90 | 5,715 | BLR6XK8 |
| 0.25% | CRSP | CRISPR THERAPEUTICS AG | -- | $194,094.61 | 3,719 | BDHF4K6 |
| 0.24% | KYMR | KYMERA THERAPEUTICS INC | -- | $185,825.25 | 2,925 | BMPRZV5 |
| 0.23% | AKRO | AKERO THERAPEUTICS INC | -- | $177,669.60 | 3,272 | BK7Y2V9 |
| 0.23% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $176,455.86 | 4,606 | BP8JSP4 |
| 0.22% | IMVT | IMMUNOVANT INC | -- | $167,103.76 | 7,129 | BJRFSB7 |
| 0.22% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $166,521.13 | 6,901 | 2713317 |
| 0.22% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $164,899.82 | 3,851 | BDD19F8 |
| 0.22% | LGND | LIGAND PHARMACEUTICALS | -- | $164,899.22 | 802 | 2501578 |
| 0.21% | ADMA | ADMA BIOLOGICS INC | -- | $160,666.06 | 9,761 | B9NSBM2 |
| 0.21% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $158,271.82 | 862 | BQ721R4 |
| 0.20% | INDV | INDIVIOR PLC | -- | $153,630.40 | 5,104 | BP0BQQ5 |
| 0.20% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $152,879.30 | 12,847 | BFNF1D6 |
| 0.19% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $145,452.90 | 2,055 | BJDX8Y8 |
| 0.18% | VCYT | VERACYTE INC | -- | $136,121.40 | 3,218 | BFTWZY0 |
| 0.17% | TVTX | TRAVERE THERAPEUTICS INC | -- | $132,933.15 | 3,645 | BLFGJD5 |
| 0.17% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $132,208.79 | 3,943 | BJ62Z18 |
| 0.17% | TARS | TARSUS PHARMACEUTICALS INC | -- | $129,122.06 | 1,726 | BMH5RL1 |
| 0.17% | MLYS | MINERALYS THERAPEUTICS INC | -- | $128,406.29 | 2,713 | BP9N0G0 |
| 0.16% | GRAL | GRAIL INC | -- | $125,120.52 | 1,476 | BSLSSX7 |
| 0.16% | XENE | XENON PHARMACEUTICALS INC | -- | $125,111.04 | 3,153 | BRJ3GY4 |
| 0.16% | CGON | CG ONCOLOGY INC | -- | $122,959.20 | 3,120 | BRBCSP4 |
| 0.16% | IRON | DISC MEDICINE INC | -- | $122,406.46 | 1,423 | BMGJZJ8 |
| 0.16% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $121,215.06 | 3,933 | BFZQ0L8 |
| 0.16% | APGE | APOGEE THERAPEUTICS INC | -- | $119,069.70 | 1,887 | BM9HHL5 |
| 0.16% | FOLD | AMICUS THERAPEUTICS INC | -- | $118,776.78 | 12,609 | B19FQ48 |
| 0.15% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $115,022.25 | 4,905 | BKX9VD3 |
| 0.15% | IDYA | IDEAYA BIOSCIENCES INC | -- | $114,508.80 | 3,584 | BK0VHF6 |
| 0.14% | DYN | DYNE THERAPEUTICS INC | -- | $108,291.59 | 5,819 | BN15WD1 |
| 0.14% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $107,335.53 | 3,443 | BMX9K07 |
| 0.14% | DNLI | DENALI THERAPEUTICS INC | -- | $104,804.64 | 5,982 | BD2B4V0 |
| 0.14% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $104,744.10 | 3,923 | BLB0YQ9 |
| 0.14% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $103,708.51 | 2,377 | BCBVTX1 |
| 0.14% | APLS | APELLIS PHARMACEUTICALS INC | -- | $103,443.34 | 5,167 | BYTQ6X1 |
| 0.13% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $102,402.90 | 2,295 | B72ZBG4 |
| 0.12% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $91,221.53 | 4,309 | BKY5JZ8 |
| 0.12% | BEAM | BEAM THERAPEUTICS INC | -- | $90,519.93 | 4,139 | BK6L288 |
| 0.12% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $90,306.00 | 6,228 | BJ5FZ74 |
| 0.11% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $87,572.96 | 2,438 | BQS9486 |
| 0.11% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $83,682.90 | 5,385 | BFWLC09 |
| 0.11% | VCEL | VERICEL CORP | -- | $83,427.72 | 2,063 | BSBMN89 |
| 0.11% | OCUL | OCULAR THERAPEUTIX INC | -- | $81,774.33 | 7,117 | BNZB1X8 |
| 0.11% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $81,277.35 | 17,479 | BM9FJ13 |
| 0.11% | VERA | VERA THERAPEUTICS INC | -- | $81,118.80 | 2,610 | BL55460 |
| 0.10% | IBRX | IMMUNITYBIO INC | -- | $79,649.90 | 38,665 | BNSP0B8 |
| 0.10% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $78,886.08 | 2,352 | BKSGZN7 |
| 0.10% | TWST | TWIST BIOSCIENCE CORP | -- | $78,687.03 | 2,469 | BGKG6G7 |
| 0.10% | TXG | 10X GENOMICS INC-CLASS A | -- | $78,125.89 | 4,681 | BKS3RS7 |
| 0.10% | ANIP | ANI PHARMACEUTICALS INC | -- | $77,408.49 | 887 | BCDWBX6 |
| 0.10% | AVDL | AVADEL PHARMACEUTICALS | -- | $76,044.65 | 3,971 | BDGMC59 |
| 0.09% | TERN | TERNS PHARMACEUTICALS INC | -- | $72,633.40 | 3,578 | BMDJ0C9 |
| 0.09% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $72,151.24 | 1,778 | BRXB0C0 |
| 0.09% | SRPT | SAREPTA THERAPEUTICS INC | -- | $71,964.00 | 3,998 | B8DPDT7 |
| 0.09% | ALVO | ALVOTECH SA | -- | $71,691.20 | 12,802 | BPNTJ34 |
| 0.09% | JANX | JANUX THERAPEUTICS INC | -- | $70,102.16 | 2,458 | BMFX8Y7 |
| 0.09% | QURE | UNIQURE NV | -- | $67,770.00 | 2,250 | BJFSR88 |
| 0.09% | MNKD | MANNKIND CORP | -- | $65,892.75 | 12,551 | BF081J4 |
| 0.08% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $61,654.66 | 8,587 | 2100362 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $61,034.15 | 1,289 | BX7RSN3 |
| 0.08% | ZYME | ZYMEWORKS INC | -- | $59,562.75 | 3,075 | BPCQZY9 |
| 0.08% | ARDX | ARDELYX INC | -- | $59,530.24 | 9,856 | BN89V40 |
| 0.08% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $59,184.75 | 3,525 | BN7Q7R7 |
| 0.08% | TRVI | TREVI THERAPEUTICS INC | -- | $59,024.85 | 4,981 | BJH9ZN0 |
| 0.08% | HROW | HARROW INC | -- | $58,159.72 | 1,513 | BHNDW86 |
| 0.08% | SYRE | SPYRE THERAPEUTICS INC | -- | $57,872.10 | 2,470 | BQBBDY8 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $57,805.02 | 1,638 | BLCD809 |
| 0.08% | INVA | INNOVIVA INC | -- | $57,460.12 | 2,579 | BDDXF67 |
| 0.07% | STOK | STOKE THERAPEUTICS INC | -- | $56,341.46 | 2,242 | BJQ05Z6 |
| 0.07% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $54,002.96 | 4,796 | BRJZSK0 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $52,904.83 | 1,901 | BNFWZS4 |
| 0.07% | GMAB | GENMAB A/S -SP ADR | -- | $52,256.05 | 1,715 | BBC9WC7 |
| 0.07% | NVCR | NOVOCURE LTD | -- | $51,949.28 | 4,573 | BYSS4X4 |
| 0.07% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $50,139.54 | 6,606 | BLR7H87 |
| 0.06% | ORIC | ORIC PHARMACEUTICALS INC | -- | $49,570.56 | 3,972 | BKVDFF7 |
| 0.06% | CVAC | CUREVAC NV | -- | $49,181.40 | 9,210 | BN4RD42 |
| 0.06% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $49,166.60 | 2,422 | BMFD115 |
| 0.06% | PGEN | PRECIGEN INC | -- | $48,991.74 | 12,187 | BKM5C84 |
| 0.06% | TSHA | TAYSHA GENE THERAPIES INC | -- | $48,644.52 | 11,157 | BNC1BX1 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $48,529.28 | 12,224 | BL53SR3 |
| 0.06% | NVAX | NOVAVAX INC | -- | $47,829.60 | 6,643 | BJDQXG4 |
| 0.06% | URGN | UROGEN PHARMA LTD | -- | $47,590.02 | 1,893 | BZ7PJQ1 |
| 0.06% | WVE | WAVE LIFE SCIENCES LTD | -- | $45,270.10 | 6,509 | BYZG9R0 |
| 0.06% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $44,955.18 | 3,646 | BPCK358 |
| 0.06% | PCRX | PACIRA BIOSCIENCES INC | -- | $43,854.68 | 1,838 | B3X26D8 |
| 0.06% | RLAY | RELAY THERAPEUTICS INC | -- | $43,510.84 | 7,052 | BN2R582 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $43,478.76 | 593 | BNSP8K3 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $43,363.10 | 4,990 | B8K7T65 |
| 0.06% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $43,314.26 | 4,189 | BLB0YH0 |
| 0.06% | ORKA | ORUKA THERAPEUTICS INC | -- | $43,299.00 | 1,530 | BKVF0J2 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $42,962.92 | 10,582 | BMFJJ97 |
| 0.06% | ZLAB | ZAI LAB LTD-ADR | -- | $42,819.16 | 1,957 | BD9GVY0 |
| 0.06% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $42,398.00 | 2,900 | BJLKVS6 |
| 0.06% | FTRE | FORTREA HOLDINGS INC | -- | $42,105.42 | 3,713 | BRXYZ57 |
| 0.05% | XNCR | XENCOR INC | -- | $41,990.02 | 2,918 | BGCYWN8 |
| 0.05% | NTLA | INTELLIA THERAPEUTICS INC | -- | $41,661.10 | 4,390 | BYZM6C2 |
| 0.05% | CSTL | CASTLE BIOSCIENCES INC | -- | $41,261.70 | 1,185 | BKLCWZ3 |
| 0.05% | NRIX | NURIX THERAPEUTICS INC | -- | $38,067.76 | 3,128 | BMVLGP2 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $37,955.28 | 7,842 | BZ0QMB7 |
| 0.05% | ANAB | ANAPTYSBIO INC | -- | $37,921.14 | 1,146 | BDRW1L7 |
| 0.05% | KURA | KURA ONCOLOGY INC | -- | $37,914.00 | 3,550 | BYZD465 |
| 0.05% | MNMD | MIND MEDICINE MINDMED INC | -- | $37,803.96 | 3,114 | BPQYY97 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $37,751.56 | 833 | BL95N25 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $37,597.08 | 14,802 | BF0DMK7 |
| 0.05% | RAPP | RAPPORT THERAPEUTICS INC | -- | $37,578.81 | 1,493 | BR3T9B6 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $36,626.80 | 2,060 | BMNDK09 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $36,155.69 | 4,042 | BMCR7V2 |
| 0.05% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $35,768.16 | 2,526 | BP7KZP7 |
| 0.05% | TNGX | TANGO THERAPEUTICS INC | -- | $34,913.84 | 4,552 | BP2P6L0 |
| 0.05% | CRMD | CORMEDIX INC | -- | $34,876.68 | 3,054 | BJ0LT31 |
| 0.04% | EYPT | EYEPOINT PHARMACEUTICALS INC | -- | $33,823.79 | 2,821 | BMGS7L1 |
| 0.04% | TYRA | TYRA BIOSCIENCES INC | -- | $33,792.84 | 2,183 | BMVNDH9 |
| 0.04% | AVBP | ARRIVENT BIOPHARMA INC | -- | $33,511.80 | 1,659 | BMGTLY5 |
| 0.04% | VIR | VIR BIOTECHNOLOGY INC | -- | $32,444.22 | 5,682 | BK4PZ38 |
| 0.04% | GERN | GERON CORP | -- | $32,360.28 | 26,097 | 2370381 |
| 0.04% | ARVN | ARVINAS INC | -- | $31,261.23 | 3,003 | BDZ30Q0 |
| 0.04% | ERAS | ERASCA INC | -- | $30,750.60 | 11,604 | BNLYBF3 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $30,301.00 | 1,930 | BQS7491 |
| 0.04% | LENZ | LENZ THERAPEUTICS INC | -- | $29,733.00 | 1,166 | BQV0J03 |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $29,315.96 | 734 | BQD3J33 |
| 0.04% | SVRA | SAVARA INC | -- | $29,132.52 | 7,071 | BYXGN81 |
| 0.04% | PSNL | PERSONALIS INC | -- | $29,052.27 | 3,627 | BJQ0608 |
| 0.04% | KROS | KEROS THERAPEUTICS INC | -- | $29,000.20 | 1,660 | BM7V485 |
| 0.04% | ATXS | ASTRIA THERAPEUTICS INC | -- | $28,977.95 | 2,309 | BMYRFN8 |
| 0.04% | REPL | REPLIMUNE GROUP INC | -- | $28,873.76 | 3,194 | BDDVW37 |
| 0.04% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $28,491.40 | 3,290 | BFYQFJ2 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $27,604.26 | 4,947 | BYVQJ96 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $27,467.06 | 2,059 | BD06CS0 |
| 0.03% | PRME | PRIME MEDICINE INC | -- | $25,393.15 | 7,153 | BPBJFM7 |
| 0.03% | ESPR | ESPERION THERAPEUTICS INC | -- | $24,991.44 | 8,248 | BBNBTD2 |
| 0.03% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $24,940.82 | 3,049 | BYP80F1 |
| 0.03% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $24,232.80 | 3,512 | BYTYP72 |
| 0.03% | RGNX | REGENXBIO INC | -- | $23,954.00 | 2,065 | BZ0G875 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $23,880.85 | 2,201 | B91XRN2 |
| 0.03% | LXRX | LEXICON PHARMACEUTICALS INC | -- | $22,893.64 | 14,866 | BWFZX59 |
| 0.03% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $22,624.42 | 2,807 | BMZ4LN0 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $21,986.72 | 3,752 | BMC3HS7 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $21,591.80 | 2,297 | BLFBZ32 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $21,379.38 | 12,287 | B4N8MH9 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $20,952.70 | 1,910 | BKLXFX5 |
| 0.03% | ABSI | ABSCI CORP | -- | $20,797.80 | 6,117 | BN94K69 |
| 0.03% | ALMS | ALUMIS INC | -- | $20,766.12 | 3,963 | BPLQG36 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $20,659.73 | 6,643 | B3MZ6K5 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $20,335.68 | 2,208 | BQ6C357 |
| 0.03% | CGEM | CULLINAN THERAPEUTICS INC | -- | $20,165.25 | 2,415 | BM90J52 |
| 0.03% | HCM | HUTCHMED CHINA-ADR | -- | $19,405.60 | 1,270 | BYXV9H7 |
| 0.03% | EOLS | EVOLUS INC | -- | $19,323.10 | 2,647 | BDRJH21 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $19,236.75 | 5,919 | BMCWKZ2 |
| 0.03% | OMER | OMEROS CORP | -- | $19,181.76 | 2,784 | B4NB858 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $18,965.97 | 587 | B292NQ7 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $18,944.64 | 6,624 | BN4JN37 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $18,189.09 | 2,929 | 2107437 |
| 0.02% | NGNE | NEUROGENE INC | -- | $18,181.80 | 585 | BS2F741 |
| 0.02% | DSGN | DESIGN THERAPEUTICS INC | -- | $17,723.69 | 2,329 | BMFK3H6 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $15,274.53 | 3,611 | BFY7DC4 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $15,101.64 | 3,186 | BQHN6C7 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $14,569.50 | 4,415 | BDFKQ07 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $14,427.90 | 765 | BPBPCG8 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $14,147.80 | 2,540 | BP81R42 |
| 0.02% | LYEL | LYELL IMMUNOPHARMA INC | -- | $13,874.81 | 787 | BTNMG41 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $13,470.96 | 4,107 | BZC0D70 |
| 0.02% | AMRN | AMARIN CORP PLC -ADR | -- | $13,357.04 | 824 | BN72KB0 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $12,966.77 | 1,769 | BSMLR16 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $12,928.33 | 1,921 | BL5B6Z1 |
| 0.02% | ANNX | ANNEXON INC | -- | $12,765.80 | 4,495 | BMVV9R5 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $12,471.57 | 1,557 | BP81RK8 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $12,411.52 | 1,892 | BKDQKM6 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $11,795.00 | 3,500 | BMXNGZ6 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $11,364.50 | 3,247 | BLN9Z50 |
| 0.01% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $11,163.48 | 9,076 | BFZNYB7 |
| 0.01% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $11,157.44 | 8,204 | BFMLGR4 |
| 0.01% | PYXS | PYXIS ONCOLOGY INC | -- | $11,082.32 | 2,536 | BLBR8D5 |
| 0.01% | VNDA | VANDA PHARMACEUTICALS INC | -- | $10,654.56 | 2,416 | B12W3P6 |
| 0.01% | FHTX | FOGHORN THERAPEUTICS INC | -- | $10,477.89 | 2,313 | BMF7DT9 |
| 0.01% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $10,438.75 | 875 | B9L5200 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $9,933.30 | 3,679 | BZ8FPH3 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $9,762.94 | 2,189 | BP7L561 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $9,639.00 | 2,268 | BY7RB53 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $9,024.30 | 1,110 | BKC9SX3 |
| 0.01% | HUMA | HUMACYTE INC | -- | $8,098.75 | 6,479 | BMYTJP4 |
| 0.01% | RNAC | CARTESIAN THERAPEUTICS INC | -- | $8,072.70 | 1,065 | BQB9HM8 |
| 0.01% | OABI | OMNIAB INC | -- | $7,878.26 | 5,018 | BN13S71 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $7,221.76 | 2,912 | BKX9NQ0 |
| 0.01% | CDXS | CODEXIS INC | -- | $7,125.56 | 3,692 | B5LL2C2 |
| 0.01% | MXCT | MAXCYTE INC | -- | $6,890.38 | 4,361 | BKMQF66 |
| 0.01% | PEPG | PEPGEN INC | -- | $6,889.59 | 1,343 | BMTX3D7 |
| 0.01% | NKTX | NKARTA INC | -- | $5,697.72 | 2,907 | BK80YJ8 |
| 0.01% | ALEC | ALECTOR INC | -- | $5,548.94 | 4,141 | BJ4LDC4 |
| 0.01% | APLT | APPLIED THERAPEUTICS INC | -- | $5,345.93 | 5,874 | BJL38Z1 |
| 0.01% | CLYM | CLIMB BIO INC | -- | $5,324.16 | 2,773 | BMW5LX6 |
| 0.01% | FATE | FATE THERAPEUTICS INC | -- | $4,905.68 | 4,717 | BCZS820 |
| 0.01% | PLRX | PLIANT THERAPEUTICS INC | -- | $4,521.60 | 2,512 | BMDWW66 |
| 0.01% | ARTV | ARTIVA BIOTHERAPEUTICS INC | -- | $3,980.00 | 1,000 | BMF1LJ7 |
| -- | MGNX | MACROGENICS INC | -- | $3,801.42 | 2,586 | BFDV8K0 |
| -- | TVGN | TEVOGEN BIO HOLDINGS INC | -- | $3,747.49 | 8,047 | BPG5P75 |
| -- | BMEA | BIOMEA FUSION INC | -- | $3,335.95 | 2,435 | BNKF6N0 |
| -- | ACRV | ACRIVON THERAPEUTICS INC | -- | $2,934.36 | 1,287 | BP2TPK4 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $2,812.20 | 3,468 | BF12XC2 |
| -- | TCRX | TSCAN THERAPEUTICS INC | -- | $2,552.55 | 2,145 | BNLYBJ7 |
| -- | MRSN | MERSANA THERAPEUTICS INC | -- | $1,809.48 | 204 | BVPKH99 |
| -- | OKUR | ONKURE THERAPEUTICS INC-A | -- | $1,620.08 | 526 | BT7KGT6 |
| -- | QTTB | Q32 BIO INC | -- | $1,210.14 | 498 | BS2FKQ4 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 36.26% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 27,753,612 | -- | 5,015 | -- |
| 34.25% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 26,215,126 | -- | 4,737 | -- |
| 22.23% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 17,017,419 | -- | 3,075 | -- |
| 17.96% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 13,746,754 | -- | 2,484 | -- |
| 16.62% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 12,722,942 | -- | 2,299 | -- |
| 8.35% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 6,391,909 | -- | 1,155 | -- |
| -- | -- | TREASURY BILL | -- | $4,996,336.65 | 5,000,000 | BMGHP58 |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $22,122,105.98 | 22,122,106 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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