BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
View fund details
Documents & Downloads
ETF & Index
Prospectus & Regulatory
You may order paper copies by contacting ProShares Client Services at 866-PRO-5125 (866-776-5125)
Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 11/30/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 16.90% | 51.72% | 95.62% | 66.67% | 42.59% | 11.36% | 1.61% | 2.01% | 16.86% | 04/07/2010 |
| BIB Market Price | 17.00% | 51.90% | 95.85% | 66.74% | 42.98% | 11.47% | 1.66% | 2.03% | 16.87% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/16/2025- NAV $79.31
- NAV Change $-0.92
- Market Price $79.32
- Market Price Change $-0.89
- Trading Volume (M) 8,520
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/16/2025- NAV $79.31
- NAV Change $-0.92
- Market Price $79.32
- Market Price Change $-0.89
- Trading Volume (M) 8,520
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 12/16/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.52% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $4,597,370.80 | 10,105 | 2931034 |
| 5.39% | AMGN | AMGEN INC | -- | $4,487,120.42 | 13,733 | 2023607 |
| 4.99% | GILD | GILEAD SCIENCES INC | -- | $4,154,330.50 | 34,975 | 2369174 |
| 4.42% | REGN | REGENERON PHARMACEUTICALS | -- | $3,681,793.88 | 4,933 | 2730190 |
| 2.92% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,427,992.19 | 6,207 | B00FWN1 |
| 2.71% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $2,258,720.10 | 24,726 | 2989044 |
| 2.43% | INSM | INSMED INC | -- | $2,024,960.97 | 10,091 | 2614487 |
| 1.49% | ARGX | ARGENX SE - ADR | -- | $1,244,776.04 | 1,462 | BDVLM39 |
| 1.44% | BIIB | BIOGEN INC | -- | $1,200,500.00 | 7,000 | 2455965 |
| 1.30% | UTHR | UNITED THERAPEUTICS CORP | -- | $1,079,500.00 | 2,159 | 2430412 |
| 1.16% | ILMN | ILLUMINA INC | -- | $965,518.84 | 7,339 | 2613990 |
| 1.09% | INCY | INCYTE CORP | -- | $904,707.72 | 9,324 | 2471950 |
| 0.95% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $792,201.58 | 20,641 | BMVP7Y0 |
| 0.90% | MEDP | MEDPACE HOLDINGS INC | -- | $749,270.34 | 1,341 | BDCBC61 |
| 0.90% | ROIV | ROIVANT SCIENCES LTD | -- | $747,958.70 | 32,605 | BMW4NZ9 |
| 0.85% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $704,432.64 | 4,736 | 2623911 |
| 0.83% | RVMD | REVOLUTION MEDICINES INC | -- | $692,223.00 | 8,925 | BL71K91 |
| 0.83% | BBIO | BRIDGEBIO PHARMA INC | -- | $690,898.32 | 9,128 | BK1KWG8 |
| 0.77% | VTRS | VIATRIS INC | -- | $637,932.36 | 55,666 | BMWS3X9 |
| 0.74% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $616,179.55 | 2,905 | BV9G6B8 |
| 0.73% | SMMT | SUMMIT THERAPEUTICS INC | -- | $611,113.64 | 35,468 | BMTVQS7 |
| 0.73% | SNY | SANOFI-ADR | -- | $607,753.84 | 12,811 | 2964557 |
| 0.72% | IONS | IONIS PHARMACEUTICALS INC | -- | $596,395.70 | 7,610 | BDJ0LS6 |
| 0.71% | GH | GUARDANT HEALTH INC | -- | $595,400.00 | 5,954 | BFXC911 |
| 0.71% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $590,062.48 | 1,064 | BD59BS7 |
| 0.67% | MRNA | MODERNA INC | -- | $555,266.53 | 18,577 | BGSXTS3 |
| 0.66% | TEM | TEMPUS AI INC | -- | $548,626.05 | 8,055 | BSLSJJ0 |
| 0.64% | EXEL | EXELIXIS INC | -- | $534,684.80 | 12,853 | 2576941 |
| 0.59% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $491,538.08 | 2,896 | B4Q5ZN4 |
| 0.59% | ONC | BEONE MEDICINES LTD-ADR | -- | $488,417.55 | 1,605 | BYYWPW6 |
| 0.57% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $474,886.21 | 9,173 | 2437071 |
| 0.53% | BNTX | BIONTECH SE-ADR | -- | $442,980.69 | 4,803 | BK6H543 |
| 0.53% | RNA | AVIDITY BIOSCIENCES INC | -- | $442,111.71 | 6,143 | BMWHPY1 |
| 0.51% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $426,820.66 | 6,601 | BYQBFJ8 |
| 0.43% | HALO | HALOZYME THERAPEUTICS INC | -- | $360,064.95 | 5,585 | 2975098 |
| 0.43% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $356,803.85 | 3,173 | BF2YWG4 |
| 0.43% | CYTK | CYTOKINETICS INC | -- | $354,320.26 | 5,713 | BBBSBJ5 |
| 0.42% | AXSM | AXSOME THERAPEUTICS INC | -- | $349,991.21 | 2,383 | BYZR4X4 |
| 0.40% | KRYS | KRYSTAL BIOTECH INC | -- | $329,676.10 | 1,382 | BD6JX35 |
| 0.39% | NUVL | NUVALENT INC-A | -- | $326,671.29 | 3,183 | BMVBZD3 |
| 0.35% | KYMR | KYMERA THERAPEUTICS INC | -- | $287,424.66 | 3,414 | BMPRZV5 |
| 0.34% | PTCT | PTC THERAPEUTICS INC | -- | $286,068.06 | 3,793 | B17VCN9 |
| 0.33% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $275,882.55 | 1,005 | BQ721R4 |
| 0.33% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $271,873.80 | 2,970 | BDCBCD8 |
| 0.33% | PCVX | VAXCYTE INC | -- | $270,710.33 | 6,199 | BKPVGH6 |
| 0.32% | COGT | COGENT BIOSCIENCES INC | -- | $266,733.30 | 6,670 | BLR6XK8 |
| 0.29% | CRSP | CRISPR THERAPEUTICS AG | -- | $243,077.71 | 4,343 | BDHF4K6 |
| 0.27% | IMVT | IMMUNOVANT INC | -- | $221,475.03 | 8,323 | BJRFSB7 |
| 0.27% | ALKS | ALKERMES PLC | -- | $221,168.92 | 7,882 | B3P6D26 |
| 0.26% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $218,599.17 | 4,497 | BDD19F8 |
| 0.26% | ADMA | ADMA BIOLOGICS INC | -- | $218,422.98 | 11,394 | B9NSBM2 |
| 0.26% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $215,874.00 | 8,055 | 2713317 |
| 0.25% | INDV | INDIVIOR PLC | -- | $210,758.66 | 5,957 | BP0BQQ5 |
| 0.24% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $203,428.80 | 4,590 | BFZQ0L8 |
| 0.22% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $184,035.16 | 5,378 | BP8JSP4 |
| 0.22% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $182,501.32 | 14,996 | BFNF1D6 |
| 0.22% | LGND | LIGAND PHARMACEUTICALS | -- | $180,301.68 | 936 | 2501578 |
| 0.22% | TERN | TERNS PHARMACEUTICALS INC | -- | $179,319.76 | 4,178 | BMDJ0C9 |
| 0.21% | ACLX | ARCELLX INC | -- | $175,641.84 | 2,648 | BPCJ1Q2 |
| 0.21% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $175,132.98 | 2,838 | BQS9486 |
| 0.20% | APGE | APOGEE THERAPEUTICS INC | -- | $164,665.56 | 2,202 | BM9HHL5 |
| 0.20% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $163,334.25 | 5,725 | BKX9VD3 |
| 0.19% | VCYT | VERACYTE INC | -- | $162,334.32 | 3,756 | BFTWZY0 |
| 0.19% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $160,852.95 | 2,399 | BJDX8Y8 |
| 0.19% | FOLD | AMICUS THERAPEUTICS INC | -- | $160,268.13 | 14,717 | B19FQ48 |
| 0.19% | XENE | XENON PHARMACEUTICALS INC | -- | $158,326.00 | 3,682 | BRJ3GY4 |
| 0.19% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $157,998.34 | 4,601 | BJ62Z18 |
| 0.19% | TARS | TARSUS PHARMACEUTICALS INC | -- | $157,812.48 | 2,016 | BMH5RL1 |
| 0.18% | APLS | APELLIS PHARMACEUTICALS INC | -- | $152,619.30 | 6,030 | BYTQ6X1 |
| 0.18% | TVTX | TRAVERE THERAPEUTICS INC | -- | $152,577.60 | 4,256 | BLFGJD5 |
| 0.18% | IRON | DISC MEDICINE INC | -- | $151,840.20 | 1,660 | BMGJZJ8 |
| 0.18% | GRAL | GRAIL INC | -- | $149,761.42 | 1,721 | BSLSSX7 |
| 0.18% | VERA | VERA THERAPEUTICS INC | -- | $147,170.10 | 3,047 | BL55460 |
| 0.17% | IDYA | IDEAYA BIOSCIENCES INC | -- | $141,494.85 | 4,185 | BK0VHF6 |
| 0.17% | CGON | CG ONCOLOGY INC | -- | $137,811.85 | 3,641 | BRBCSP4 |
| 0.16% | DYN | DYNE THERAPEUTICS INC | -- | $132,803.15 | 6,793 | BN15WD1 |
| 0.16% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $129,352.64 | 2,677 | B72ZBG4 |
| 0.16% | BEAM | BEAM THERAPEUTICS INC | -- | $129,250.80 | 4,830 | BK6L288 |
| 0.15% | WVE | WAVE LIFE SCIENCES LTD | -- | $124,683.18 | 7,598 | BYZG9R0 |
| 0.14% | OCUL | OCULAR THERAPEUTIX INC | -- | $119,552.12 | 8,308 | BNZB1X8 |
| 0.14% | DNLI | DENALI THERAPEUTICS INC | -- | $118,816.62 | 6,981 | BD2B4V0 |
| 0.14% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $117,823.32 | 4,581 | BLB0YQ9 |
| 0.14% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $115,827.03 | 7,271 | BJ5FZ74 |
| 0.14% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $114,533.10 | 5,030 | BKY5JZ8 |
| 0.14% | MLYS | MINERALYS THERAPEUTICS INC | -- | $114,066.60 | 3,165 | BP9N0G0 |
| 0.13% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $112,335.56 | 3,277 | BMZ4LN0 |
| 0.13% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $106,666.01 | 2,747 | BKSGZN7 |
| 0.12% | SRPT | SAREPTA THERAPEUTICS INC | -- | $104,076.15 | 4,665 | B8DPDT7 |
| 0.12% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $99,490.45 | 6,277 | BFWLC09 |
| 0.12% | AVDL | AVADEL PHARMACEUTICALS | -- | $99,071.32 | 4,636 | BDGMC59 |
| 0.12% | IBRX | IMMUNITYBIO INC | -- | $97,487.28 | 45,133 | BNSP0B8 |
| 0.11% | SYRE | SPYRE THERAPEUTICS INC | -- | $95,085.48 | 2,884 | BQBBDY8 |
| 0.11% | ZYME | ZYMEWORKS INC | -- | $92,775.65 | 3,589 | BPCQZY9 |
| 0.11% | TWST | TWIST BIOSCIENCE CORP | -- | $89,747.79 | 2,883 | BGKG6G7 |
| 0.11% | STOK | STOKE THERAPEUTICS INC | -- | $87,923.76 | 2,616 | BJQ05Z6 |
| 0.10% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $87,033.00 | 4,020 | BMX9K07 |
| 0.10% | MNKD | MANNKIND CORP | -- | $86,581.50 | 14,650 | BF081J4 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $85,884.12 | 2,076 | BRXB0C0 |
| 0.10% | TXG | 10X GENOMICS INC-CLASS A | -- | $85,823.73 | 5,463 | BKS3RS7 |
| 0.10% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $85,692.60 | 20,403 | BM9FJ13 |
| 0.10% | VCEL | VERICEL CORP | -- | $85,519.50 | 2,409 | BSBMN89 |
| 0.10% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $85,221.36 | 4,113 | BN7Q7R7 |
| 0.10% | ANIP | ANI PHARMACEUTICALS INC | -- | $84,019.60 | 1,036 | BCDWBX6 |
| 0.09% | HROW | HARROW INC | -- | $79,108.59 | 1,767 | BHNDW86 |
| 0.09% | TSHA | TAYSHA GENE THERAPIES INC | -- | $75,805.50 | 13,025 | BNC1BX1 |
| 0.09% | ALVO | ALVOTECH SA | -- | $75,327.84 | 14,946 | BPNTJ34 |
| 0.09% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $74,871.81 | 10,023 | 2100362 |
| 0.09% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $73,259.84 | 1,504 | BX7RSN3 |
| 0.09% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $72,373.66 | 2,774 | BCBVTX1 |
| 0.09% | TRVI | TREVI THERAPEUTICS INC | -- | $72,151.74 | 5,814 | BJH9ZN0 |
| 0.08% | RLAY | RELAY THERAPEUTICS INC | -- | $69,807.36 | 8,232 | BN2R582 |
| 0.08% | FTRE | FORTREA HOLDINGS INC | -- | $69,316.65 | 4,335 | BRXYZ57 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $69,233.52 | 1,912 | BLCD809 |
| 0.08% | ARDX | ARDELYX INC | -- | $69,036.00 | 11,506 | BN89V40 |
| 0.08% | NVCR | NOVOCURE LTD | -- | $69,020.34 | 5,338 | BYSS4X4 |
| 0.08% | NRIX | NURIX THERAPEUTICS INC | -- | $68,766.00 | 3,650 | BMVLGP2 |
| 0.08% | GMAB | GENMAB A/S -SP ADR | -- | $62,762.70 | 2,002 | BBC9WC7 |
| 0.07% | SANA | SANA BIOTECHNOLOGY INC | -- | $61,760.00 | 12,352 | BMFJJ97 |
| 0.07% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $60,357.22 | 5,599 | BRJZSK0 |
| 0.07% | ANAB | ANAPTYSBIO INC | -- | $60,205.11 | 1,337 | BDRW1L7 |
| 0.07% | INVA | INNOVIVA INC | -- | $59,939.28 | 3,009 | BDDXF67 |
| 0.07% | TYRA | TYRA BIOSCIENCES INC | -- | $58,458.65 | 2,545 | BMVNDH9 |
| 0.07% | QURE | UNIQURE NV | -- | $57,351.80 | 2,620 | BJFSR88 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $56,854.20 | 2,220 | BNFWZS4 |
| 0.07% | INBX | INHIBRX BIOSCIENCES INC | -- | $56,446.44 | 692 | BNSP8K3 |
| 0.07% | XNCR | XENCOR INC | -- | $56,352.75 | 3,405 | BGCYWN8 |
| 0.07% | PCRX | PACIRA BIOSCIENCES INC | -- | $56,156.10 | 2,145 | B3X26D8 |
| 0.07% | EYPT | EYEPOINT PHARMACEUTICALS INC | -- | $55,716.63 | 3,291 | BMGS7L1 |
| 0.07% | PGEN | PRECIGEN INC | -- | $55,058.49 | 14,227 | BKM5C84 |
| 0.07% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $55,028.34 | 2,949 | BP7KZP7 |
| 0.07% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $54,741.00 | 7,710 | BLR7H87 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $54,084.25 | 1,385 | BKLCWZ3 |
| 0.06% | RAPP | RAPPORT THERAPEUTICS INC | -- | $53,614.68 | 1,743 | BR3T9B6 |
| 0.06% | SVRA | SAVARA INC | -- | $53,060.36 | 8,252 | BYXGN81 |
| 0.06% | ALMS | ALUMIS INC | -- | $52,736.40 | 4,626 | BPLQG36 |
| 0.06% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $52,403.67 | 4,257 | BPCK358 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $52,192.00 | 5,825 | B8K7T65 |
| 0.06% | URGN | UROGEN PHARMA LTD | -- | $51,845.23 | 2,209 | BZ7PJQ1 |
| 0.06% | ORKA | ORUKA THERAPEUTICS INC | -- | $51,744.72 | 1,788 | BKVF0J2 |
| 0.06% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $51,617.88 | 3,387 | BJLKVS6 |
| 0.06% | NVAX | NOVAVAX INC | -- | $50,717.70 | 7,755 | BJDQXG4 |
| 0.06% | SPRY | ARS PHARMACEUTICALS INC | -- | $50,304.54 | 4,719 | BMCR7V2 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $49,367.28 | 14,268 | BL53SR3 |
| 0.06% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $47,821.48 | 2,828 | BMFD115 |
| 0.06% | ERAS | ERASCA INC | -- | $47,674.88 | 13,544 | BNLYBF3 |
| 0.06% | TNGX | TANGO THERAPEUTICS INC | -- | $47,595.52 | 5,312 | BP2P6L0 |
| 0.06% | NTLA | INTELLIA THERAPEUTICS INC | -- | $46,740.00 | 5,125 | BYZM6C2 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $44,764.07 | 1,937 | BMGTLY5 |
| 0.05% | MNMD | MIND MEDICINE MINDMED INC | -- | $44,540.58 | 3,633 | BPQYY97 |
| 0.05% | KURA | KURA ONCOLOGY INC | -- | $44,050.72 | 4,144 | BYZD465 |
| 0.05% | VIR | VIR BIOTECHNOLOGY INC | -- | $42,981.84 | 6,633 | BK4PZ38 |
| 0.05% | ORIC | ORIC PHARMACEUTICALS INC | -- | $42,289.44 | 4,637 | BKVDFF7 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $42,159.65 | 2,405 | BMNDK09 |
| 0.05% | JANX | JANUX THERAPEUTICS INC | -- | $42,030.85 | 2,869 | BMFX8Y7 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $42,012.27 | 9,153 | BZ0QMB7 |
| 0.05% | KROS | KEROS THERAPEUTICS INC | -- | $41,746.67 | 1,939 | BM7V485 |
| 0.05% | ARVN | ARVINAS INC | -- | $41,745.20 | 3,508 | BDZ30Q0 |
| 0.05% | MESO | MESOBLAST LTD- SPON ADR | -- | $41,225.66 | 2,254 | BQS7491 |
| 0.05% | GERN | GERON CORP | -- | $40,820.42 | 30,463 | 2370381 |
| 0.05% | CRMD | CORMEDIX INC | -- | $40,772.16 | 3,564 | BJ0LT31 |
| 0.05% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $40,350.75 | 4,891 | BLB0YH0 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $39,268.80 | 972 | BL95N25 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $38,873.25 | 17,277 | BF0DMK7 |
| 0.05% | ZLAB | ZAI LAB LTD-ADR | -- | $38,811.00 | 2,283 | BD9GVY0 |
| 0.05% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $38,255.40 | 2,406 | BD06CS0 |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $35,969.12 | 856 | BQD3J33 |
| 0.04% | REPL | REPLIMUNE GROUP INC | -- | $35,816.47 | 3,727 | BDDVW37 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $35,716.17 | 9,627 | BBNBTD2 |
| 0.04% | ATXS | ASTRIA THERAPEUTICS INC | -- | $34,684.65 | 2,695 | BMYRFN8 |
| 0.04% | RGNX | REGENXBIO INC | -- | $34,033.32 | 2,412 | BZ0G875 |
| 0.04% | PSNL | PERSONALIS INC | -- | $33,787.32 | 4,234 | BJQ0608 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $33,616.32 | 5,776 | BYVQJ96 |
| 0.04% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $33,032.60 | 3,841 | BFYQFJ2 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $32,394.12 | 8,349 | BPBJFM7 |
| 0.04% | LYEL | LYELL IMMUNOPHARMA INC | -- | $29,930.88 | 917 | BTNMG41 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $28,970.84 | 14,342 | B4N8MH9 |
| 0.03% | CGEM | CULLINAN THERAPEUTICS INC | -- | $28,830.62 | 2,821 | BM90J52 |
| 0.03% | OMER | OMEROS CORP | -- | $28,477.49 | 3,249 | B4NB858 |
| 0.03% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $28,266.40 | 3,560 | BYP80F1 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $27,981.81 | 4,379 | BMC3HS7 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $27,456.24 | 7,756 | B3MZ6K5 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $26,156.78 | 2,719 | BMFK3H6 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $25,689.60 | 2,230 | BKLXFX5 |
| 0.03% | ABSI | ABSCI CORP | -- | $25,343.45 | 7,139 | BN94K69 |
| 0.03% | ANNX | ANNEXON INC | -- | $25,185.60 | 5,247 | BMVV9R5 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $25,083.94 | 2,578 | BQ6C357 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $25,057.50 | 2,570 | B91XRN2 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $24,799.72 | 6,908 | BMCWKZ2 |
| 0.03% | LENZ | LENZ THERAPEUTICS INC | -- | $22,745.40 | 1,362 | BQV0J03 |
| 0.03% | EOLS | EVOLUS INC | -- | $22,302.58 | 3,089 | BDRJH21 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $21,761.60 | 2,680 | BLFBZ32 |
| 0.03% | SLDB | SOLID BIOSCIENCES INC | -- | $21,638.76 | 3,718 | BQHN6C7 |
| 0.03% | SIGA | SIGA TECHNOLOGIES INC | -- | $21,471.32 | 3,419 | 2107437 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $21,258.72 | 684 | B292NQ7 |
| 0.03% | ALT | ALTIMMUNE INC | -- | $21,196.42 | 4,214 | BFY7DC4 |
| 0.03% | KYTX | KYVERNA THERAPEUTICS INC | -- | $21,145.60 | 2,065 | BSMLR16 |
| 0.03% | LXRX | LEXICON PHARMACEUTICALS INC | -- | $20,821.20 | 17,351 | BWFZX59 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $20,647.92 | 1,816 | BP81RK8 |
| 0.02% | HCM | HUTCHMED CHINA-ADR | -- | $19,534.39 | 1,481 | BYXV9H7 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $18,759.65 | 2,821 | B12W3P6 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $18,329.88 | 2,966 | BP81R42 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $17,671.36 | 5,152 | BDFKQ07 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $16,690.17 | 893 | BPBPCG8 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $16,486.02 | 4,101 | BYTYP72 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $16,314.76 | 10,594 | BFZNYB7 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $16,133.17 | 2,207 | BKDQKM6 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $15,772.26 | 4,794 | BZC0D70 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $15,323.20 | 9,577 | BFMLGR4 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $15,285.38 | 4,087 | BMXNGZ6 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $15,161.85 | 1,021 | B9L5200 |
| 0.02% | CLYM | CLIMB BIO INC | -- | $14,950.32 | 3,236 | BMW5LX6 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $14,304.20 | 7,732 | BN4JN37 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $14,057.34 | 2,242 | BL5B6Z1 |
| 0.02% | AMRN | AMARIN CORP PLC -ADR | -- | $13,453.11 | 963 | BN72KB0 |
| 0.02% | NGNE | NEUROGENE INC | -- | $13,299.93 | 681 | BS2F741 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $12,200.58 | 3,789 | BLN9Z50 |
| 0.01% | FHTX | FOGHORN THERAPEUTICS INC | -- | $12,091.52 | 2,699 | BMF7DT9 |
| 0.01% | OABI | OMNIAB INC | -- | $12,010.95 | 5,859 | BN13S71 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $11,855.20 | 2,555 | BP7L561 |
| 0.01% | PYXS | PYXIS ONCOLOGY INC | -- | $11,844.00 | 2,961 | BLBR8D5 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $11,704.16 | 2,648 | BY7RB53 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $10,775.43 | 4,293 | BZ8FPH3 |
| 0.01% | RNAC | CARTESIAN THERAPEUTICS INC | -- | $10,296.18 | 1,242 | BQB9HM8 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $9,247.61 | 1,297 | BKC9SX3 |
| 0.01% | PEPG | PEPGEN INC | -- | $8,644.32 | 1,566 | BMTX3D7 |
| 0.01% | HUMA | HUMACYTE INC | -- | $8,469.44 | 7,562 | BMYTJP4 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $7,679.48 | 3,398 | BKX9NQ0 |
| 0.01% | MXCT | MAXCYTE INC | -- | $7,482.30 | 5,090 | BKMQF66 |
| 0.01% | CDXS | CODEXIS INC | -- | $7,240.80 | 4,310 | B5LL2C2 |
| 0.01% | MRSN | MERSANA THERAPEUTICS INC | -- | $6,912.71 | 238 | BVPKH99 |
| 0.01% | ALEC | ALECTOR INC | -- | $6,717.87 | 4,833 | BJ4LDC4 |
| 0.01% | NKTX | NKARTA INC | -- | $6,171.62 | 3,391 | BK80YJ8 |
| 0.01% | FATE | FATE THERAPEUTICS INC | -- | $6,002.63 | 5,507 | BCZS820 |
| 0.01% | ARTV | ARTIVA BIOTHERAPEUTICS INC | -- | $5,305.30 | 1,166 | BMF1LJ7 |
| -- | MGNX | MACROGENICS INC | -- | $4,074.30 | 3,018 | BFDV8K0 |
| -- | -- | SUTRO BIOPHARMA INC COMMON STOCK USD 0.001 | -- | $3,973.05 | 405 | -- |
| -- | BMEA | BIOMEA FUSION INC | -- | $3,892.17 | 2,841 | BNKF6N0 |
| -- | PLRX | PLIANT THERAPEUTICS INC | -- | $3,663.75 | 2,931 | BMDWW66 |
| -- | ACRV | ACRIVON THERAPEUTICS INC | -- | $3,634.84 | 1,502 | BP2TPK4 |
| -- | TVGN | TEVOGEN BIO HOLDINGS INC | -- | $3,606.53 | 9,392 | BPG5P75 |
| -- | TCRX | TSCAN THERAPEUTICS INC | -- | $2,384.51 | 2,505 | BNLYBJ7 |
| -- | OKUR | ONKURE THERAPEUTICS INC-A | -- | $1,851.26 | 613 | BT7KGT6 |
| -- | QTTB | Q32 BIO INC | -- | $1,676.16 | 582 | BS2FKQ4 |
| -- | APLT | APPLIED THERAPEUTICS INC | -- | $829.93 | 6,876 | BJL38Z1 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| 34.14% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 28,428,813 | -- | 5,008 | -- |
| 32.99% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 27,475,131 | -- | 4,840 | -- |
| 25.94% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 21,605,444 | -- | 3,806 | -- |
| 16.93% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,100,873 | -- | 2,484 | -- |
| 15.67% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 13,050,687 | -- | 2,299 | -- |
| 4.32% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,593,338 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $24,697,426.97 | 24,697,427 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
Read More