BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 3/31/2026
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | -7.55% | 2.21% | 37.13% | 2.21% | 70.94% | 15.59% | 0.06% | 7.43% | 16.31% | 04/07/2010 |
| BIB Market Price | -7.52% | 2.18% | 37.06% | 2.18% | 70.63% | 15.62% | 0.04% | 7.44% | 16.31% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | -7.52% | 2.18% | 37.06% | 2.18% | 70.63% | 15.62% | 0.04% | 7.44% | 16.31% | 04/07/2010 |
| BIB NAV | -7.55% | 2.21% | 37.13% | 2.21% | 70.94% | 15.59% | 0.06% | 7.43% | 16.31% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Net Assets $80,272,391
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time
- Distributions Quarterly
- Options Available Yes
Price
as of 4/06/2026- NAV
- NAV Change
- Market Price $81.04
- Market Price Change $-0.73
- Trading Volume (M) 5,946
- 30-Day Median Bid Ask Spread 0.25%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Net Assets $80,272,391
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time
- Distributions Quarterly
- Options Available Yes
Price
as of 4/06/2026- NAV
- NAV Change
- Market Price $81.04
- Market Price Change $-0.73
- Trading Volume (M) 5,946
- 30-Day Median Bid Ask Spread 0.25%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 12/31/2025
Holdings
as of 4/06/2026
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.40% | GILD | GILEAD SCIENCES INC | -- | $4,330,717.65 | 30,905 | 2369174 |
| 5.06% | AMGN | AMGEN INC | -- | $4,062,880.20 | 11,860 | 2023607 |
| 5.01% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $4,023,789.50 | 9,265 | 2931034 |
| 4.42% | REGN | REGENERON PHARMACEUTICALS | -- | $3,545,846.88 | 4,647 | 2730190 |
| 2.44% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $1,959,576.88 | 5,932 | B00FWN1 |
| 1.97% | INSM | INSMED INC | -- | $1,579,456.02 | 9,642 | 2614487 |
| 1.41% | BIIB | BIOGEN INC | -- | $1,131,239.76 | 6,564 | 2455965 |
| 1.37% | UTHR | UNITED THERAPEUTICS CORP | -- | $1,096,914.00 | 1,960 | 2430412 |
| 1.18% | ARGX | ARGENX SE - ADR | -- | $949,529.25 | 1,269 | BDVLM39 |
| 1.13% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $906,887.80 | 19,165 | BMVP7Y0 |
| 1.11% | ROIV | ROIVANT SCIENCES LTD | -- | $892,633.96 | 32,017 | BMW4NZ9 |
| 1.09% | ILMN | ILLUMINA INC | -- | $873,869.34 | 6,841 | 2613990 |
| 1.07% | MRNA | MODERNA INC | -- | $861,619.59 | 17,667 | BGSXTS3 |
| 1.05% | RVMD | REVOLUTION MEDICINES INC | -- | $845,366.40 | 8,865 | BL71K91 |
| 1.05% | INCY | INCYTE CORP | -- | $844,443.72 | 8,902 | 2471950 |
| 0.86% | VTRS | VIATRIS INC | -- | $690,708.87 | 51,507 | BMWS3X9 |
| 0.81% | SMMT | SUMMIT THERAPEUTICS INC | -- | $648,281.34 | 34,686 | BMTVQS7 |
| 0.78% | MEDP | MEDPACE HOLDINGS INC | -- | $629,424.00 | 1,269 | BDCBC61 |
| 0.78% | BBIO | BRIDGEBIO PHARMA INC | -- | $626,884.44 | 8,673 | BK1KWG8 |
| 0.78% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $624,304.26 | 2,754 | BV9G6B8 |
| 0.74% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $594,835.20 | 4,490 | 2623911 |
| 0.68% | IONS | IONIS PHARMACEUTICALS INC | -- | $549,298.70 | 7,390 | BDJ0LS6 |
| 0.68% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $548,294.76 | 1,027 | BD59BS7 |
| 0.66% | GH | GUARDANT HEALTH INC | -- | $526,035.22 | 5,867 | BFXC911 |
| 0.65% | SNY | SANOFI-ADR | -- | $521,172.40 | 10,949 | 2964557 |
| 0.64% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $514,584.90 | 2,754 | B4Q5ZN4 |
| 0.64% | EXEL | EXELIXIS INC | -- | $510,915.66 | 11,617 | 2576941 |
| 0.60% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $483,630.84 | 8,604 | 2437071 |
| 0.58% | BNTX | BIONTECH SE-ADR | -- | $465,162.88 | 5,096 | BK6H543 |
| 0.54% | ONC | BEONE MEDICINES LTD-ADR | -- | $432,560.70 | 1,430 | BYYWPW6 |
| 0.48% | AXSM | AXSOME THERAPEUTICS INC | -- | $388,534.86 | 2,289 | BYZR4X4 |
| 0.48% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $386,086.95 | 1,245 | BQ721R4 |
| 0.48% | PCVX | VAXCYTE INC | -- | $385,121.16 | 6,438 | BKPVGH6 |
| 0.48% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $382,916.80 | 6,265 | BYQBFJ8 |
| 0.46% | TEM | TEMPUS AI INC-CL A | -- | $367,568.30 | 7,771 | BSLSJJ0 |
| 0.45% | CYTK | CYTOKINETICS INC | -- | $357,754.46 | 5,509 | BBBSBJ5 |
| 0.43% | KRYS | KRYSTAL BIOTECH INC | -- | $342,696.20 | 1,309 | BD6JX35 |
| 0.42% | NUVL | NUVALENT INC-A | -- | $339,546.54 | 3,274 | BMVBZD3 |
| 0.41% | HALO | HALOZYME THERAPEUTICS INC | -- | $333,062.40 | 5,280 | 2975098 |
| 0.41% | ABVX | ABIVAX SA-ADR | -- | $328,303.56 | 2,748 | BLC89B2 |
| 0.41% | IBRX | IMMUNITYBIO INC | -- | $325,616.28 | 45,991 | BNSP0B8 |
| 0.39% | KYMR | KYMERA THERAPEUTICS INC | -- | $311,320.77 | 3,651 | BMPRZV5 |
| 0.37% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $293,750.95 | 2,855 | BDCBCD8 |
| 0.33% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $265,662.80 | 3,055 | BF2YWG4 |
| 0.32% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $259,751.76 | 2,699 | BJDX8Y8 |
| 0.32% | COGT | COGENT BIOSCIENCES INC | -- | $257,184.62 | 7,261 | BLR6XK8 |
| 0.32% | CGON | CG ONCOLOGY INC | -- | $255,203.90 | 3,778 | BRBCSP4 |
| 0.32% | PTCT | PTC THERAPEUTICS INC | -- | $255,136.70 | 3,703 | B17VCN9 |
| 0.32% | ALKS | ALKERMES PLC | -- | $254,066.40 | 7,455 | B3P6D26 |
| 0.31% | TERN | TERNS PHARMACEUTICALS INC | -- | $251,074.46 | 4,757 | BMDJ0C9 |
| 0.30% | CAI | CARIS LIFE SCIENCES INC | -- | $239,944.22 | 12,622 | BT18HP9 |
| 0.30% | ERAS | ERASCA INC | -- | $237,112.00 | 13,850 | BNLYBF3 |
| 0.29% | APLS | APELLIS PHARMACEUTICALS INC | -- | $232,322.34 | 5,718 | BYTQ6X1 |
| 0.28% | IMVT | IMMUNOVANT INC | -- | $226,648.34 | 9,106 | BJRFSB7 |
| 0.28% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $222,768.84 | 4,564 | BFZQ0L8 |
| 0.26% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $212,274.17 | 5,351 | BLB0YQ9 |
| 0.26% | XENE | XENON PHARMACEUTICALS INC | -- | $211,558.48 | 3,722 | BRJ3GY4 |
| 0.26% | CRSP | CRISPR THERAPEUTICS AG | -- | $211,000.95 | 4,293 | BDHF4K6 |
| 0.26% | APGE | APOGEE THERAPEUTICS INC | -- | $205,992.52 | 2,452 | BM9HHL5 |
| 0.23% | LGND | LIGAND PHARMACEUTICALS | -- | $181,416.51 | 891 | 2501578 |
| 0.22% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $180,418.45 | 3,485 | BQS9486 |
| 0.22% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $176,586.80 | 4,684 | BDD19F8 |
| 0.22% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $175,445.04 | 5,142 | BP8JSP4 |
| 0.22% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $173,838.60 | 14,076 | BFNF1D6 |
| 0.21% | SYRE | SPYRE THERAPEUTICS INC | -- | $172,066.74 | 3,513 | BQBBDY8 |
| 0.21% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $170,212.32 | 7,626 | 2713317 |
| 0.21% | INDV | INDIVIOR PHARMACEUTICALS INC | -- | $170,169.48 | 5,594 | BTZRLN8 |
| 0.20% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $157,518.34 | 4,798 | BKY5JZ8 |
| 0.17% | TWST | TWIST BIOSCIENCE CORP | -- | $140,335.56 | 2,742 | BGKG6G7 |
| 0.17% | DNLI | DENALI THERAPEUTICS INC | -- | $137,501.10 | 7,095 | BD2B4V0 |
| 0.17% | DYN | DYNE THERAPEUTICS INC | -- | $135,147.75 | 7,365 | BN15WD1 |
| 0.17% | TARS | TARSUS PHARMACEUTICALS INC | -- | $133,571.57 | 1,903 | BMH5RL1 |
| 0.16% | TVTX | TRAVERE THERAPEUTICS INC | -- | $131,362.41 | 4,127 | BLFGJD5 |
| 0.16% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $131,143.32 | 5,544 | BKX9VD3 |
| 0.16% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $129,635.10 | 2,565 | B72ZBG4 |
| 0.16% | VERA | VERA THERAPEUTICS INC | -- | $129,100.44 | 3,192 | BL55460 |
| 0.16% | IDYA | IDEAYA BIOSCIENCES INC | -- | $127,063.86 | 3,929 | BK0VHF6 |
| 0.15% | ALMS | ALUMIS INC | -- | $124,070.70 | 5,655 | BPLQG36 |
| 0.15% | TNGX | TANGO THERAPEUTICS INC | -- | $122,247.25 | 6,025 | BP2P6L0 |
| 0.15% | ORKA | ORUKA THERAPEUTICS INC | -- | $122,041.05 | 2,165 | BKVF0J2 |
| 0.14% | TXG | 10X GENOMICS INC-CLASS A | -- | $115,228.96 | 5,264 | BKS3RS7 |
| 0.14% | VCYT | VERACYTE INC | -- | $114,897.60 | 3,555 | BFTWZY0 |
| 0.14% | IRON | DISC MEDICINE INC | -- | $112,354.74 | 1,707 | BMGJZJ8 |
| 0.14% | BEAM | BEAM THERAPEUTICS INC | -- | $110,416.11 | 4,557 | BK6L288 |
| 0.13% | SRPT | SAREPTA THERAPEUTICS INC | -- | $106,886.40 | 4,688 | B8DPDT7 |
| 0.13% | KOD | KODIAK SCIENCES INC | -- | $106,470.00 | 2,730 | BFXC933 |
| 0.13% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $106,253.40 | 11,220 | 2100362 |
| 0.13% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $103,424.64 | 2,656 | BMFD115 |
| 0.13% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $101,726.15 | 2,053 | BRXB0C0 |
| 0.12% | MLYS | MINERALYS THERAPEUTICS INC | -- | $99,934.20 | 3,540 | BP9N0G0 |
| 0.12% | RLAY | RELAY THERAPEUTICS INC | -- | $99,537.75 | 7,995 | BN2R582 |
| 0.12% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $99,166.66 | 4,621 | BLB0YH0 |
| 0.12% | ADMA | ADMA BIOLOGICS INC | -- | $98,869.12 | 10,654 | B9NSBM2 |
| 0.12% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $98,867.01 | 4,323 | BJ62Z18 |
| 0.12% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $96,983.04 | 6,888 | BJ5FZ74 |
| 0.12% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $95,824.05 | 3,945 | BN7Q7R7 |
| 0.12% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $95,168.00 | 5,948 | BFWLC09 |
| 0.12% | TYRA | TYRA BIOSCIENCES INC | -- | $92,925.91 | 2,387 | BMVNDH9 |
| 0.11% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $91,210.80 | 2,621 | BCBVTX1 |
| 0.11% | DFTX | DEFINIUM THERAPEUTICS INC | -- | $91,117.80 | 4,460 | BV2DHY6 |
| 0.11% | GRAL | GRAIL INC | -- | $90,182.82 | 1,743 | BSLSSX7 |
| 0.11% | ZYME | ZYMEWORKS INC | -- | $86,512.32 | 3,348 | BPCQZY9 |
| 0.10% | STOK | STOKE THERAPEUTICS INC | -- | $83,778.45 | 2,555 | BJQ05Z6 |
| 0.10% | PHVS | PHARVARIS NV | -- | $81,308.42 | 2,866 | BMZ2X38 |
| 0.10% | GMAB | GENMAB A/S -SP ADR | -- | $79,892.25 | 2,879 | BBC9WC7 |
| 0.10% | OCUL | OCULAR THERAPEUTIX INC | -- | $78,593.73 | 9,739 | BNZB1X8 |
| 0.10% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $77,723.66 | 4,913 | BPCK358 |
| 0.10% | ANIP | ANI PHARMACEUTICALS INC | -- | $77,431.60 | 1,003 | BCDWBX6 |
| 0.10% | ANAB | ANAPTYSBIO INC | -- | $77,413.20 | 1,240 | BDRW1L7 |
| 0.10% | VCEL | VERICEL CORP | -- | $77,395.68 | 2,271 | BSBMN89 |
| 0.10% | INVA | INNOVIVA INC | -- | $76,265.26 | 3,313 | BDDXF67 |
| 0.09% | SION | SIONNA THERAPEUTICS INC | -- | $74,647.86 | 1,997 | BQKXDX4 |
| 0.09% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $73,549.35 | 23,349 | BM9FJ13 |
| 0.09% | TRVI | TREVI THERAPEUTICS INC | -- | $73,478.16 | 5,736 | BJH9ZN0 |
| 0.09% | NRIX | NURIX THERAPEUTICS INC | -- | $72,634.00 | 4,600 | BMVLGP2 |
| 0.09% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $71,713.48 | 2,588 | BKSGZN7 |
| 0.09% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $70,535.68 | 3,776 | BMX9K07 |
| 0.09% | NTLA | INTELLIA THERAPEUTICS INC | -- | $70,277.20 | 5,284 | BYZM6C2 |
| 0.09% | RAPP | RAPPORT THERAPEUTICS INC | -- | $69,034.16 | 2,132 | BR3T9B6 |
| 0.08% | PGEN | PRECIGEN INC | -- | $66,319.32 | 15,828 | BKM5C84 |
| 0.08% | ARDX | ARDELYX INC | -- | $65,490.90 | 10,970 | BN89V40 |
| 0.08% | VIR | VIR BIOTECHNOLOGY INC | -- | $63,700.86 | 7,031 | BK4PZ38 |
| 0.08% | MBX | MBX BIOSCIENCES INC | -- | $62,881.70 | 2,009 | BQXJKH2 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $62,634.34 | 1,961 | BLCD809 |
| 0.08% | ATAI | ATAIBECKLEY INC | -- | $62,554.80 | 16,248 | BWJDYK1 |
| 0.08% | MAZE | MAZE THERAPEUTICS INC | -- | $62,437.00 | 2,153 | BSRK699 |
| 0.08% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $60,812.40 | 18,428 | BF0DMK7 |
| 0.07% | WVE | WAVE LIFE SCIENCES LTD | -- | $59,704.89 | 8,421 | BYZG9R0 |
| 0.07% | BCAX | BICARA THERAPEUTICS INC | -- | $59,088.90 | 2,834 | BQB42F1 |
| 0.07% | HROW | HARROW INC | -- | $58,245.54 | 1,658 | BHNDW86 |
| 0.07% | NVAX | NOVAVAX INC | -- | $58,085.36 | 7,288 | BJDQXG4 |
| 0.07% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $57,748.23 | 3,411 | BP7KZP7 |
| 0.07% | TSHA | TAYSHA GENE THERAPIES INC | -- | $56,976.45 | 12,253 | BNC1BX1 |
| 0.07% | ALVO | ALVOTECH SA | -- | $56,001.04 | 14,776 | BPNTJ34 |
| 0.07% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $54,384.45 | 3,585 | BMZ4LN0 |
| 0.07% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $54,338.74 | 3,694 | BYP80F1 |
| 0.07% | ZBIO | ZENAS BIOPHARMA INC | -- | $54,203.10 | 2,435 | BQB42H3 |
| 0.07% | NVCR | NOVOCURE LTD | -- | $53,699.50 | 5,090 | BYSS4X4 |
| 0.06% | SVRA | SAVARA INC | -- | $50,976.80 | 9,103 | BYXGN81 |
| 0.06% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $50,709.62 | 923 | BL95N25 |
| 0.06% | GERN | GERON CORP | -- | $49,973.00 | 28,556 | 2370381 |
| 0.06% | SEPN | SEPTERNA INC | -- | $49,634.34 | 2,003 | BQNKXX2 |
| 0.06% | EYPT | EYEPOINT INC | -- | $48,559.44 | 3,704 | BMGS7L1 |
| 0.06% | QURE | UNIQURE NV | -- | $48,465.93 | 2,787 | BJFSR88 |
| 0.06% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $46,310.39 | 1,421 | BX7RSN3 |
| 0.06% | AVBP | ARRIVENT BIOPHARMA INC | -- | $46,119.59 | 1,847 | BMGTLY5 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $45,975.18 | 13,562 | BL53SR3 |
| 0.06% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $45,649.59 | 2,261 | BD06CS0 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $44,911.11 | 5,457 | B8K7T65 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $44,903.10 | 7,422 | BLR7H87 |
| 0.05% | GHRS | GH RESEARCH PLC | -- | $42,013.50 | 2,775 | BP6C0S2 |
| 0.05% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $41,756.82 | 2,029 | BNFWZS4 |
| 0.05% | INBX | INHIBRX BIOSCIENCES INC | -- | $41,481.72 | 651 | BNSP8K3 |
| 0.05% | XNCR | XENCOR INC | -- | $40,815.64 | 3,281 | BGCYWN8 |
| 0.05% | JANX | JANUX THERAPEUTICS INC | -- | $40,666.68 | 2,722 | BMFX8Y7 |
| 0.05% | PCRX | PACIRA BIOSCIENCES INC | -- | $40,308.70 | 1,810 | B3X26D8 |
| 0.05% | ORIC | ORIC PHARMACEUTICALS INC | -- | $40,005.90 | 4,490 | BKVDFF7 |
| 0.05% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $39,645.00 | 3,524 | BJLKVS6 |
| 0.05% | CGEM | CULLINAN THERAPEUTICS INC | -- | $39,433.56 | 2,643 | BM90J52 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $38,950.73 | 2,093 | BZ7PJQ1 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $38,373.84 | 8,604 | BZ0QMB7 |
| 0.05% | SANA | SANA BIOTECHNOLOGY INC | -- | $38,369.52 | 11,916 | BMFJJ97 |
| 0.05% | FTRE | FORTREA HOLDINGS INC | -- | $37,688.83 | 4,183 | BRXYZ57 |
| 0.05% | ANNX | ANNEXON INC | -- | $37,555.00 | 6,475 | BMVV9R5 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $37,108.97 | 4,423 | BMCR7V2 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $36,498.70 | 2,267 | BMNDK09 |
| 0.04% | MNKD | MANNKIND CORP | -- | $35,284.48 | 13,783 | BF081J4 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $34,825.54 | 2,342 | BQS7491 |
| 0.04% | OMER | OMEROS CORP | -- | $34,516.34 | 3,171 | B4NB858 |
| 0.04% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $34,272.00 | 3,600 | BFYQFJ2 |
| 0.04% | BIOA | BIOAGE LABS INC | -- | $34,078.32 | 1,944 | BT9K6D8 |
| 0.04% | CTMX | CYTOMX THERAPEUTICS INC | -- | $33,347.60 | 7,579 | BYWVTY5 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $33,043.08 | 3,892 | BYZD465 |
| 0.04% | CSTL | CASTLE BIOSCIENCES INC | -- | $32,890.90 | 1,330 | BKLCWZ3 |
| 0.04% | ARVN | ARVINAS INC | -- | $32,111.64 | 2,862 | BDZ30Q0 |
| 0.04% | DSGN | DESIGN THERAPEUTICS INC | -- | $31,926.44 | 2,548 | BMFK3H6 |
| 0.04% | REPL | REPLIMUNE GROUP INC | -- | $31,546.76 | 3,694 | BDDVW37 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $31,426.50 | 1,533 | BD9GVY0 |
| 0.04% | PSNL | PERSONALIS INC | -- | $30,800.98 | 4,681 | BJQ0608 |
| 0.04% | VOR | VOR BIOPHARMA INC | -- | $30,229.66 | 1,858 | BRJJYT3 |
| 0.04% | ETON | ETON PHARMACEUTICALS INC | -- | $29,975.00 | 1,199 | BGL0JK3 |
| 0.03% | ESPR | ESPERION THERAPEUTICS INC | -- | $27,269.70 | 10,694 | BBNBTD2 |
| 0.03% | SLDB | SOLID BIOSCIENCES INC | -- | $26,981.64 | 3,486 | BQHN6C7 |
| 0.03% | PRME | PRIME MEDICINE INC | -- | $26,970.50 | 8,075 | BPBJFM7 |
| 0.03% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $26,137.80 | 10,053 | BFZNYB7 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $25,705.46 | 7,282 | B3MZ6K5 |
| 0.03% | TECX | TECTONIC THERAPEUTIC INC | -- | $25,183.20 | 840 | BPBPCG8 |
| 0.03% | CRMD | CORMEDIX INC | -- | $24,949.92 | 3,524 | BJ0LT31 |
| 0.03% | LRMR | LARIMAR THERAPEUTICS INC | -- | $24,527.85 | 4,857 | BMXNGZ6 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $24,515.58 | 2,517 | BLFBZ32 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $24,265.00 | 4,220 | BMC3HS7 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $24,176.32 | 2,408 | B91XRN2 |
| 0.03% | TRDA | ENTRADA THERAPEUTICS INC | -- | $23,776.44 | 1,713 | BP81RK8 |
| 0.03% | UPB | UPSTREAM BIO INC | -- | $23,502.96 | 2,418 | BRCFFK6 |
| 0.03% | FULC | FULCRUM THERAPEUTICS INC | -- | $23,325.57 | 2,979 | BJDX8Z9 |
| 0.03% | KYTX | KYVERNA THERAPEUTICS INC | -- | $22,952.88 | 2,556 | BSMLR16 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $22,683.08 | 2,282 | BKLXFX5 |
| 0.03% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $22,323.22 | 5,458 | BYVQJ96 |
| 0.03% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $22,243.68 | 813 | BQD3J33 |
| 0.03% | KMDA | KAMADA LTD | -- | $21,370.68 | 2,581 | B2Q9833 |
| 0.03% | LYEL | LYELL IMMUNOPHARMA INC | -- | $20,627.19 | 951 | BTNMG41 |
| 0.03% | AVIR | ATEA PHARMACEUTICALS INC | -- | $20,515.65 | 3,495 | BLN9Z50 |
| 0.03% | ACRS | ACLARIS THERAPEUTICS INC | -- | $20,501.00 | 5,395 | BYV2W40 |
| 0.02% | RGNX | REGENXBIO INC | -- | $19,923.20 | 2,264 | BZ0G875 |
| 0.02% | ABSI | ABSCI CORP | -- | $19,908.96 | 6,726 | BN94K69 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $19,521.60 | 664 | B292NQ7 |
| 0.02% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $19,319.55 | 6,549 | BMCWKZ2 |
| 0.02% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $19,182.78 | 13,509 | B4N8MH9 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $18,977.88 | 2,841 | BP81R42 |
| 0.02% | LXEO | LEXEO THERAPEUTICS INC | -- | $18,839.05 | 3,265 | BQ6C357 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $18,654.66 | 5,602 | BFY7DC4 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $18,498.38 | 2,654 | B12W3P6 |
| 0.02% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $18,305.28 | 1,362 | BPRBTY7 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $17,211.75 | 1,299 | B9L5200 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $16,808.68 | 4,858 | BDFKQ07 |
| 0.02% | CADL | CANDEL THERAPEUTICS INC | -- | $16,415.40 | 3,270 | BP0TQC5 |
| 0.02% | KROS | KEROS THERAPEUTICS INC | -- | $16,178.81 | 1,363 | BM7V485 |
| 0.02% | IVVD | INVIVYD INC | -- | $16,114.80 | 12,396 | BM8NHS1 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $15,847.00 | 7,475 | BN4JN37 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $15,681.64 | 2,276 | B7F2TY6 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $15,498.00 | 2,870 | BMVBZF5 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $14,738.40 | 3,204 | 2107437 |
| 0.02% | NGNE | NEUROGENE INC | -- | $14,165.24 | 692 | BS2F741 |
| 0.02% | LENZ | LENZ THERAPEUTICS INC | -- | $13,444.39 | 1,399 | BQV0J03 |
| 0.02% | CABA | CABALETTA BIO INC | -- | $12,961.06 | 4,306 | BK5MWR1 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $12,785.60 | 2,620 | BMF7DT9 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $12,472.47 | 8,973 | BFMLGR4 |
| 0.02% | CCCC | C4 THERAPEUTICS INC | -- | $12,393.76 | 4,364 | BKX9NQ0 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $12,272.16 | 4,146 | BYTYP72 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $12,180.00 | 2,100 | BL5B6Z1 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $12,152.70 | 4,501 | BZC0D70 |
| 0.02% | NBP | NOVABRIDGE BIOSCIENCES | -- | $12,150.82 | 5,021 | BKRRKY7 |
| 0.02% | EOLS | EVOLUS INC | -- | $12,059.84 | 2,899 | BDRJH21 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $11,875.52 | 4,366 | BZ8FPH3 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $11,167.29 | 6,687 | BRK0149 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $10,706.00 | 2,525 | BPRB2N7 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $10,468.89 | 2,637 | BY7RB53 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $10,447.62 | 1,271 | BKC9SX3 |
| 0.01% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $10,136.97 | 2,073 | BKDQKM6 |
| 0.01% | OABI | OMNIAB INC | -- | $9,916.06 | 6,439 | BN13S71 |
| 0.01% | MENS | JYONG BIOTECH LTD | -- | $8,200.40 | 3,320 | BPTK6Z2 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $8,152.95 | 4,181 | BNYJR68 |
| 0.01% | CDXS | CODEXIS INC | -- | $7,637.49 | 4,041 | B5LL2C2 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $7,469.28 | 2,394 | BP7L561 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $7,124.04 | 1,386 | BP2NYN2 |
| 0.01% | LFCR | LIFECORE BIOMEDICAL INC | -- | $6,817.25 | 1,675 | 2517058 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $6,399.36 | 9,696 | BNNXX52 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $6,373.79 | 8,742 | BNR5QT9 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $6,372.50 | 2,549 | BKTV702 |
| 0.01% | HUMA | HUMACYTE INC | -- | $5,611.45 | 8,633 | BMYTJP4 |
| 0.01% | PEPG | PEPGEN INC | -- | $5,598.32 | 3,076 | BMTX3D7 |
| 0.01% | PYXS | PYXIS ONCOLOGY INC | -- | $4,039.70 | 2,786 | BLBR8D5 |
| 0.01% | AARD | AARDVARK THERAPEUTICS INC | -- | $4,018.49 | 973 | BTXQTX3 |
| -- | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $3,621.73 | 4,363 | BNNXX18 |
| -- | GOSS | GOSSAMER BIO INC | -- | $3,581.45 | 10,354 | BJ0CK86 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $23.95 | 01 | BTFHQP5 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| 35.65% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 28,614,973 | -- | 4,911 | -- |
| 31.09% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 24,955,799 | -- | 4,283 | -- |
| 26.87% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 21,570,480 | -- | 3,702 | -- |
| 19.16% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 15,376,688 | -- | 2,639 | -- |
| 14.45% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 11,595,153 | -- | 1,990 | -- |
| 4.59% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,688,307 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $25,052,205.73 | 25,052,206 | -- |
Index
as of 12/31/2025
- Total Number of Companies262
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$7.32 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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