BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 10/31/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 20.05% | 41.93% | 51.59% | 42.58% | 20.67% | 9.55% | 2.60% | 0.91% | 15.79% | 04/07/2010 |
| BIB Market Price | 20.06% | 42.12% | 51.73% | 42.51% | 20.92% | 9.51% | 2.55% | 0.91% | 15.79% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 11/28/2025- NAV $83.56
- NAV Change $+0.09
- Market Price $83.68
- Market Price Change $+0.10
- Trading Volume (M) 10,005
- 30-Day Median Bid Ask Spread 0.28%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 11/28/2025- NAV $83.56
- NAV Change $+0.09
- Market Price $83.68
- Market Price Change $+0.10
- Trading Volume (M) 10,005
- 30-Day Median Bid Ask Spread 0.28%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 11/28/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.29% | AMGN | AMGEN INC | -- | $4,640,218.72 | 13,432 | 2023607 |
| 4.91% | GILD | GILEAD SCIENCES INC | -- | $4,305,112.24 | 34,211 | 2369174 |
| 4.88% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $4,285,367.63 | 9,883 | 2931034 |
| 4.29% | REGN | REGENERON PHARMACEUTICALS | -- | $3,764,416.75 | 4,825 | 2730190 |
| 3.12% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,739,417.33 | 6,071 | B00FWN1 |
| 2.56% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $2,242,247.76 | 24,183 | 2989044 |
| 2.34% | INSM | INSMED INC | -- | $2,051,105.44 | 9,872 | 2614487 |
| 1.49% | ARGX | ARGENX SE - ADR | -- | $1,303,219.42 | 1,429 | BDVLM39 |
| 1.42% | BIIB | BIOGEN INC | -- | $1,246,770.23 | 6,847 | 2455965 |
| 1.17% | UTHR | UNITED THERAPEUTICS CORP | -- | $1,026,432.00 | 2,112 | 2430412 |
| 1.09% | INCY | INCYTE CORP | -- | $952,570.74 | 9,119 | 2471950 |
| 1.08% | ILMN | ILLUMINA INC | -- | $943,548.10 | 7,178 | 2613990 |
| 0.92% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $807,923.76 | 20,188 | BMVP7Y0 |
| 0.89% | MEDP | MEDPACE HOLDINGS INC | -- | $777,307.52 | 1,312 | BDCBC61 |
| 0.80% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $704,652.96 | 4,631 | 2623911 |
| 0.77% | RVMD | REVOLUTION MEDICINES INC | -- | $678,844.80 | 8,730 | BL71K91 |
| 0.76% | ROIV | ROIVANT SCIENCES LTD | -- | $663,651.71 | 31,891 | BMW4NZ9 |
| 0.73% | BBIO | BRIDGEBIO PHARMA INC | -- | $642,833.27 | 8,927 | BK1KWG8 |
| 0.72% | GH | GUARDANT HEALTH INC | -- | $631,438.08 | 5,824 | BFXC911 |
| 0.71% | SNY | SANOFI-ADR | -- | $625,096.16 | 12,532 | 2964557 |
| 0.71% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $623,247.12 | 1,044 | BD59BS7 |
| 0.71% | SMMT | SUMMIT THERAPEUTICS INC | -- | $620,621.99 | 34,691 | BMTVQS7 |
| 0.70% | IONS | IONIS PHARMACEUTICALS INC | -- | $615,759.39 | 7,443 | BDJ0LS6 |
| 0.70% | TEM | TEMPUS AI INC | -- | $613,854.61 | 7,877 | BSLSJJ0 |
| 0.69% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $601,955.55 | 2,835 | BV9G6B8 |
| 0.66% | VTRS | VIATRIS INC | -- | $582,027.74 | 54,446 | BMWS3X9 |
| 0.63% | EXEL | EXELIXIS INC | -- | $555,261.07 | 12,571 | 2576941 |
| 0.61% | ONC | BEONE MEDICINES LTD-ADR | -- | $534,757.70 | 1,570 | BYYWPW6 |
| 0.57% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $501,412.45 | 8,965 | 2437071 |
| 0.57% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $499,932.96 | 2,832 | B4Q5ZN4 |
| 0.55% | BNTX | BIONTECH SE-ADR | -- | $484,598.70 | 4,698 | BK6H543 |
| 0.54% | MRNA | MODERNA INC | -- | $472,056.60 | 18,170 | BGSXTS3 |
| 0.49% | RNA | AVIDITY BIOSCIENCES INC | -- | $430,773.60 | 6,008 | BMWHPY1 |
| 0.44% | HALO | HALOZYME THERAPEUTICS INC | -- | $389,986.80 | 5,462 | 2975098 |
| 0.43% | CYTK | CYTOKINETICS INC | -- | $380,710.44 | 5,588 | BBBSBJ5 |
| 0.40% | AXSM | AXSOME THERAPEUTICS INC | -- | $353,146.50 | 2,331 | BYZR4X4 |
| 0.39% | NUVL | NUVALENT INC-A | -- | $340,515.90 | 3,114 | BMVBZD3 |
| 0.39% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $340,283.90 | 6,457 | BYQBFJ8 |
| 0.39% | MRUS | MERUS NV | -- | $339,566.48 | 3,532 | BZBY005 |
| 0.39% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $338,397.18 | 3,102 | BF2YWG4 |
| 0.36% | PTCT | PTC THERAPEUTICS INC | -- | $319,022.90 | 3,710 | B17VCN9 |
| 0.34% | PCVX | VAXCYTE INC | -- | $300,785.43 | 6,063 | BKPVGH6 |
| 0.34% | KRYS | KRYSTAL BIOTECH INC | -- | $294,518.00 | 1,351 | BD6JX35 |
| 0.30% | COGT | COGENT BIOSCIENCES INC | -- | $262,395.28 | 6,524 | BLR6XK8 |
| 0.30% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $261,450.00 | 2,905 | BDCBCD8 |
| 0.26% | ALKS | ALKERMES PLC | -- | $228,032.22 | 7,709 | B3P6D26 |
| 0.26% | CRSP | CRISPR THERAPEUTICS AG | -- | $226,712.80 | 4,240 | BDHF4K6 |
| 0.26% | KYMR | KYMERA THERAPEUTICS INC | -- | $226,651.32 | 3,339 | BMPRZV5 |
| 0.25% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $217,196.70 | 5,259 | BP8JSP4 |
| 0.24% | ADMA | ADMA BIOLOGICS INC | -- | $213,741.92 | 11,144 | B9NSBM2 |
| 0.23% | AKRO | AKERO THERAPEUTICS INC | -- | $203,088.96 | 3,736 | BK7Y2V9 |
| 0.23% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $200,372.88 | 4,398 | BDD19F8 |
| 0.23% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $197,829.40 | 4,490 | BFZQ0L8 |
| 0.22% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $197,290.16 | 7,879 | 2713317 |
| 0.22% | IMVT | IMMUNOVANT INC | -- | $196,581.00 | 8,140 | BJRFSB7 |
| 0.22% | INDV | INDIVIOR PLC | -- | $195,787.20 | 5,827 | BP0BQQ5 |
| 0.22% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $193,120.18 | 983 | BQ721R4 |
| 0.21% | ACLX | ARCELLX INC | -- | $188,318.90 | 2,590 | BPCJ1Q2 |
| 0.21% | LGND | LIGAND PHARMACEUTICALS | -- | $185,909.70 | 915 | 2501578 |
| 0.21% | GRAL | GRAIL INC | -- | $185,896.76 | 1,684 | BSLSSX7 |
| 0.21% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $183,630.84 | 14,667 | BFNF1D6 |
| 0.20% | VCYT | VERACYTE INC | -- | $173,927.16 | 3,674 | BFTWZY0 |
| 0.20% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $171,517.40 | 5,596 | BKX9VD3 |
| 0.20% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $171,375.30 | 2,346 | BJDX8Y8 |
| 0.18% | XENE | XENON PHARMACEUTICALS INC | -- | $161,036.72 | 3,601 | BRJ3GY4 |
| 0.18% | CGON | CG ONCOLOGY INC | -- | $159,675.24 | 3,561 | BRBCSP4 |
| 0.18% | TARS | TARSUS PHARMACEUTICALS INC | -- | $157,601.16 | 1,971 | BMH5RL1 |
| 0.18% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $156,409.75 | 4,501 | BJ62Z18 |
| 0.18% | APGE | APOGEE THERAPEUTICS INC | -- | $155,023.38 | 2,154 | BM9HHL5 |
| 0.17% | IRON | DISC MEDICINE INC | -- | $151,429.92 | 1,622 | BMGJZJ8 |
| 0.17% | TVTX | TRAVERE THERAPEUTICS INC | -- | $147,376.42 | 4,162 | BLFGJD5 |
| 0.17% | IDYA | IDEAYA BIOSCIENCES INC | -- | $145,757.04 | 4,092 | BK0VHF6 |
| 0.17% | DYN | DYNE THERAPEUTICS INC | -- | $145,481.70 | 6,643 | BN15WD1 |
| 0.16% | FOLD | AMICUS THERAPEUTICS INC | -- | $142,942.35 | 14,395 | B19FQ48 |
| 0.16% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $139,802.26 | 7,111 | BJ5FZ74 |
| 0.15% | MLYS | MINERALYS THERAPEUTICS INC | -- | $133,499.52 | 3,096 | BP9N0G0 |
| 0.15% | DNLI | DENALI THERAPEUTICS INC | -- | $132,960.63 | 6,829 | BD2B4V0 |
| 0.15% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $129,996.34 | 4,478 | BLB0YQ9 |
| 0.15% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $128,116.80 | 4,920 | BKY5JZ8 |
| 0.14% | APLS | APELLIS PHARMACEUTICALS INC | -- | $125,627.40 | 5,898 | BYTQ6X1 |
| 0.14% | BEAM | BEAM THERAPEUTICS INC | -- | $119,684.25 | 4,725 | BK6L288 |
| 0.14% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $119,400.21 | 2,619 | B72ZBG4 |
| 0.13% | TERN | TERNS PHARMACEUTICALS INC | -- | $114,716.91 | 4,081 | BMDJ0C9 |
| 0.12% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $108,955.72 | 3,932 | BMX9K07 |
| 0.12% | IBRX | IMMUNITYBIO INC | -- | $104,177.48 | 44,143 | BNSP0B8 |
| 0.11% | VERA | VERA THERAPEUTICS INC | -- | $100,575.00 | 2,980 | BL55460 |
| 0.11% | TXG | 10X GENOMICS INC-CLASS A | -- | $100,501.83 | 5,343 | BKS3RS7 |
| 0.11% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $99,659.23 | 2,783 | BQS9486 |
| 0.11% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $99,089.64 | 6,147 | BFWLC09 |
| 0.11% | OCUL | OCULAR THERAPEUTIX INC | -- | $98,718.75 | 8,125 | BNZB1X8 |
| 0.11% | AVDL | AVADEL PHARMACEUTICALS | -- | $97,435.66 | 4,534 | BDGMC59 |
| 0.11% | SRPT | SAREPTA THERAPEUTICS INC | -- | $97,395.76 | 4,564 | B8DPDT7 |
| 0.11% | JANX | JANUX THERAPEUTICS INC | -- | $95,656.54 | 2,806 | BMFX8Y7 |
| 0.11% | VCEL | VERICEL CORP | -- | $94,829.00 | 2,356 | BSBMN89 |
| 0.11% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $94,788.94 | 2,686 | BKSGZN7 |
| 0.11% | ZYME | ZYMEWORKS INC | -- | $93,752.10 | 3,510 | BPCQZY9 |
| 0.11% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $92,396.28 | 19,956 | BM9FJ13 |
| 0.10% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $90,765.60 | 3,205 | BMZ4LN0 |
| 0.10% | TWST | TWIST BIOSCIENCE CORP | -- | $90,236.19 | 2,819 | BGKG6G7 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $86,315.60 | 2,030 | BRXB0C0 |
| 0.10% | ANIP | ANI PHARMACEUTICALS INC | -- | $85,953.05 | 1,013 | BCDWBX6 |
| 0.10% | SYRE | SPYRE THERAPEUTICS INC | -- | $84,630.00 | 2,821 | BQBBDY8 |
| 0.09% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $79,735.86 | 4,023 | BN7Q7R7 |
| 0.09% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $79,394.80 | 2,719 | BCBVTX1 |
| 0.09% | STOK | STOKE THERAPEUTICS INC | -- | $79,098.69 | 2,559 | BJQ05Z6 |
| 0.09% | MNKD | MANNKIND CORP | -- | $76,660.15 | 14,329 | BF081J4 |
| 0.09% | TRVI | TREVI THERAPEUTICS INC | -- | $75,011.53 | 5,687 | BJH9ZN0 |
| 0.08% | ALVO | ALVOTECH SA | -- | $74,546.70 | 14,617 | BPNTJ34 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $73,865.00 | 1,870 | BLCD809 |
| 0.08% | HROW | HARROW INC | -- | $72,195.84 | 1,728 | BHNDW86 |
| 0.08% | QURE | UNIQURE NV | -- | $70,480.62 | 2,562 | BJFSR88 |
| 0.08% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $70,392.72 | 9,804 | 2100362 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $68,666.28 | 1,471 | BX7RSN3 |
| 0.08% | NVCR | NOVOCURE LTD | -- | $66,881.01 | 5,221 | BYSS4X4 |
| 0.07% | ARDX | ARDELYX INC | -- | $65,273.20 | 11,254 | BN89V40 |
| 0.07% | INVA | INNOVIVA INC | -- | $63,951.39 | 2,943 | BDDXF67 |
| 0.07% | RLAY | RELAY THERAPEUTICS INC | -- | $63,763.92 | 8,051 | BN2R582 |
| 0.07% | GMAB | GENMAB A/S -SP ADR | -- | $63,360.88 | 1,958 | BBC9WC7 |
| 0.07% | NRIX | NURIX THERAPEUTICS INC | -- | $63,082.24 | 3,568 | BMVLGP2 |
| 0.07% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $62,331.78 | 4,161 | BPCK358 |
| 0.07% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $62,262.12 | 5,476 | BRJZSK0 |
| 0.07% | URGN | UROGEN PHARMA LTD | -- | $62,258.41 | 2,161 | BZ7PJQ1 |
| 0.07% | TSHA | TAYSHA GENE THERAPIES INC | -- | $60,382.86 | 12,739 | BNC1BX1 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $60,136.70 | 2,171 | BNFWZS4 |
| 0.07% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $59,745.60 | 2,766 | BMFD115 |
| 0.07% | CVAC | CUREVAC NV | -- | $57,727.35 | 10,515 | BN4RD42 |
| 0.07% | XNCR | XENCOR INC | -- | $57,692.92 | 3,331 | BGCYWN8 |
| 0.07% | WVE | WAVE LIFE SCIENCES LTD | -- | $57,672.32 | 7,432 | BYZG9R0 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $56,949.24 | 677 | BNSP8K3 |
| 0.06% | TNGX | TANGO THERAPEUTICS INC | -- | $56,688.36 | 5,196 | BP2P6L0 |
| 0.06% | TYRA | TYRA BIOSCIENCES INC | -- | $56,151.84 | 2,489 | BMVNDH9 |
| 0.06% | ANAB | ANAPTYSBIO INC | -- | $54,478.20 | 1,308 | BDRW1L7 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $54,144.38 | 7,541 | BLR7H87 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $54,092.30 | 1,354 | BKLCWZ3 |
| 0.06% | FTRE | FORTREA HOLDINGS INC | -- | $53,890.40 | 4,240 | BRXYZ57 |
| 0.06% | ORIC | ORIC PHARMACEUTICALS INC | -- | $53,875.80 | 4,535 | BKVDFF7 |
| 0.06% | NVAX | NOVAVAX INC | -- | $53,474.25 | 7,585 | BJDQXG4 |
| 0.06% | PGEN | PRECIGEN INC | -- | $53,294.45 | 13,915 | BKM5C84 |
| 0.06% | ORKA | ORUKA THERAPEUTICS INC | -- | $52,644.90 | 1,749 | BKVF0J2 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $52,052.15 | 13,955 | BL53SR3 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $51,948.30 | 12,081 | BMFJJ97 |
| 0.06% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $51,749.06 | 3,313 | BJLKVS6 |
| 0.06% | SVRA | SAVARA INC | -- | $50,772.88 | 8,072 | BYXGN81 |
| 0.06% | RAPP | RAPPORT THERAPEUTICS INC | -- | $50,655.55 | 1,705 | BR3T9B6 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $50,418.45 | 5,697 | B8K7T65 |
| 0.06% | PCRX | PACIRA BIOSCIENCES INC | -- | $49,449.86 | 2,098 | B3X26D8 |
| 0.06% | KURA | KURA ONCOLOGY INC | -- | $49,203.42 | 4,053 | BYZD465 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $47,745.60 | 2,352 | BMNDK09 |
| 0.05% | EYPT | EYEPOINT PHARMACEUTICALS INC | -- | $47,737.77 | 3,219 | BMGS7L1 |
| 0.05% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $46,634.28 | 2,884 | BP7KZP7 |
| 0.05% | ZLAB | ZAI LAB LTD-ADR | -- | $45,575.53 | 2,233 | BD9GVY0 |
| 0.05% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $45,390.67 | 4,783 | BLB0YH0 |
| 0.05% | NTLA | INTELLIA THERAPEUTICS INC | -- | $45,066.87 | 5,013 | BYZM6C2 |
| 0.05% | MNMD | MIND MEDICINE MINDMED INC | -- | $45,034.00 | 3,560 | BPQYY97 |
| 0.05% | PSNL | PERSONALIS INC | -- | $44,432.93 | 4,141 | BJQ0608 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $44,027.10 | 4,615 | BMCR7V2 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $43,448.36 | 1,894 | BMGTLY5 |
| 0.05% | ARVN | ARVINAS INC | -- | $43,153.97 | 3,429 | BDZ30Q0 |
| 0.05% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $42,310.62 | 838 | BQD3J33 |
| 0.05% | ERAS | ERASCA INC | -- | $41,992.99 | 13,247 | BNLYBF3 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $41,740.53 | 16,899 | BF0DMK7 |
| 0.05% | VIR | VIR BIOTECHNOLOGY INC | -- | $41,646.54 | 6,487 | BK4PZ38 |
| 0.05% | LENZ | LENZ THERAPEUTICS INC | -- | $40,652.64 | 1,332 | BQV0J03 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $39,827.88 | 951 | BL95N25 |
| 0.04% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $39,478.32 | 8,952 | BZ0QMB7 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $37,992.15 | 2,205 | BQS7491 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $37,758.16 | 9,416 | BBNBTD2 |
| 0.04% | REPL | REPLIMUNE GROUP INC | -- | $36,450.00 | 3,645 | BDDVW37 |
| 0.04% | GERN | GERON CORP | -- | $35,158.10 | 29,795 | 2370381 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $34,967.31 | 5,649 | BYVQJ96 |
| 0.04% | ALMS | ALUMIS INC | -- | $34,699.08 | 4,524 | BPLQG36 |
| 0.04% | CRMD | CORMEDIX INC | -- | $34,197.66 | 3,486 | BJ0LT31 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $34,018.97 | 2,351 | BD06CS0 |
| 0.04% | ATXS | ASTRIA THERAPEUTICS INC | -- | $33,345.40 | 2,636 | BMYRFN8 |
| 0.04% | KROS | KEROS THERAPEUTICS INC | -- | $33,142.08 | 1,896 | BM7V485 |
| 0.04% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $32,542.64 | 14,027 | B4N8MH9 |
| 0.04% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $31,911.60 | 3,480 | BYP80F1 |
| 0.04% | RGNX | REGENXBIO INC | -- | $31,707.52 | 2,368 | BZ0G875 |
| 0.04% | CGEM | CULLINAN THERAPEUTICS INC | -- | $31,358.46 | 2,758 | BM90J52 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $31,194.12 | 8,166 | BPBJFM7 |
| 0.04% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $31,183.10 | 3,757 | BFYQFJ2 |
| 0.04% | OMER | OMEROS CORP | -- | $30,794.82 | 3,178 | B4NB858 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $27,025.50 | 2,514 | B91XRN2 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $26,547.50 | 7,585 | B3MZ6K5 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $25,430.46 | 2,181 | BKLXFX5 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $24,968.01 | 2,659 | BMFK3H6 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $24,866.92 | 2,522 | BQ6C357 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $24,460.34 | 6,757 | BMCWKZ2 |
| 0.03% | LXRX | LEXICON PHARMACEUTICALS INC | -- | $24,268.53 | 16,971 | BWFZX59 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $23,770.65 | 4,283 | BMC3HS7 |
| 0.03% | ANNX | ANNEXON INC | -- | $23,067.00 | 5,126 | BMVV9R5 |
| 0.03% | ABSI | ABSCI CORP | -- | $22,136.11 | 6,983 | BN94K69 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $22,103.46 | 2,622 | BLFBZ32 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $21,681.72 | 4,122 | BFY7DC4 |
| 0.02% | EOLS | EVOLUS INC | -- | $21,630.36 | 3,021 | BDRJH21 |
| 0.02% | LYEL | LYELL IMMUNOPHARMA INC | -- | $21,552.00 | 898 | BTNMG41 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $20,953.08 | 669 | B292NQ7 |
| 0.02% | HCM | HUTCHMED CHINA-ADR | -- | $20,894.58 | 1,449 | BYXV9H7 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $20,264.64 | 3,344 | 2107437 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $19,748.91 | 3,637 | BQHN6C7 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $19,146.60 | 2,901 | BP81R42 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $18,738.56 | 874 | BPBPCG8 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $18,249.79 | 1,777 | BP81RK8 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $17,233.38 | 5,039 | BDFKQ07 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $16,941.12 | 7,563 | BN4JN37 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $16,126.88 | 2,156 | BKDQKM6 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $15,493.40 | 2,020 | BSMLR16 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $15,362.13 | 4,011 | BYTYP72 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $15,128.52 | 10,362 | BFZNYB7 |
| 0.02% | PYXS | PYXIS ONCOLOGY INC | -- | $15,030.24 | 2,896 | BLBR8D5 |
| 0.02% | AMRN | AMARIN CORP PLC -ADR | -- | $15,027.77 | 941 | BN72KB0 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $14,875.18 | 2,207 | BL5B6Z1 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $14,788.24 | 2,759 | B12W3P6 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $14,149.38 | 3,997 | BMXNGZ6 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $14,105.88 | 999 | B9L5200 |
| 0.02% | NGNE | NEUROGENE INC | -- | $14,060.36 | 667 | BS2F741 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $13,930.41 | 4,659 | BZC0D70 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $13,206.06 | 9,366 | BFMLGR4 |
| 0.01% | FHTX | FOGHORN THERAPEUTICS INC | -- | $12,540.00 | 2,640 | BMF7DT9 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $11,695.32 | 2,499 | BP7L561 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $11,488.60 | 3,706 | BLN9Z50 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $10,593.10 | 2,590 | BY7RB53 |
| 0.01% | OABI | OMNIAB INC | -- | $10,371.30 | 5,730 | BN13S71 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $10,119.59 | 4,199 | BZ8FPH3 |
| 0.01% | HUMA | HUMACYTE INC | -- | $9,984.60 | 7,396 | BMYTJP4 |
| 0.01% | PEPG | PEPGEN INC | -- | $9,866.08 | 1,532 | BMTX3D7 |
| 0.01% | RNAC | CARTESIAN THERAPEUTICS INC | -- | $9,100.35 | 1,215 | BQB9HM8 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $9,008.04 | 3,324 | BKX9NQ0 |
| 0.01% | MXCT | MAXCYTE INC | -- | $8,763.04 | 4,979 | BKMQF66 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $8,609.72 | 1,268 | BKC9SX3 |
| 0.01% | CDXS | CODEXIS INC | -- | $7,291.95 | 4,215 | B5LL2C2 |
| 0.01% | MRSN | MERSANA THERAPEUTICS INC | -- | $6,391.19 | 233 | BVPKH99 |
| 0.01% | ALEC | ALECTOR INC | -- | $6,286.91 | 4,727 | BJ4LDC4 |
| 0.01% | NKTX | NKARTA INC | -- | $6,269.13 | 3,317 | BK80YJ8 |
| 0.01% | FATE | FATE THERAPEUTICS INC | -- | $6,140.04 | 5,386 | BCZS820 |
| 0.01% | CLYM | CLIMB BIO INC | -- | $5,981.85 | 3,165 | BMW5LX6 |
| 0.01% | PLRX | PLIANT THERAPEUTICS INC | -- | $4,615.87 | 2,867 | BMDWW66 |
| 0.01% | MGNX | MACROGENICS INC | -- | $4,516.56 | 2,952 | BFDV8K0 |
| -- | ARTV | ARTIVA BIOTHERAPEUTICS INC | -- | $4,290.16 | 1,141 | BMF1LJ7 |
| -- | TVGN | TEVOGEN BIO HOLDINGS INC | -- | $4,052.86 | 9,186 | BPG5P75 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $3,639.90 | 3,959 | BF12XC2 |
| -- | ACRV | ACRIVON THERAPEUTICS INC | -- | $3,466.84 | 1,469 | BP2TPK4 |
| -- | BMEA | BIOMEA FUSION INC | -- | $3,029.11 | 2,779 | BNKF6N0 |
| -- | TCRX | TSCAN THERAPEUTICS INC | -- | $2,719.50 | 2,450 | BNLYBJ7 |
| -- | OKUR | ONKURE THERAPEUTICS INC-A | -- | $1,806.00 | 600 | BT7KGT6 |
| -- | APLT | APPLIED THERAPEUTICS INC | -- | $1,748.50 | 6,725 | BJL38Z1 |
| -- | QTTB | Q32 BIO INC | -- | $1,246.11 | 569 | BS2FKQ4 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| 40.07% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 35,152,537 | -- | 6,042 | -- |
| 33.79% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 29,648,681 | -- | 5,096 | -- |
| 22.27% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 19,542,763 | -- | 3,359 | -- |
| 16.47% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,451,987 | -- | 2,484 | -- |
| 15.25% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 13,375,651 | -- | 2,299 | -- |
| 4.20% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,682,813 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $28,405,090.10 | 28,405,090 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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