BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 11/30/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 16.90% | 51.72% | 95.62% | 66.67% | 42.59% | 11.36% | 1.61% | 2.01% | 16.86% | 04/07/2010 |
| BIB Market Price | 17.00% | 51.90% | 95.85% | 66.74% | 42.98% | 11.47% | 1.66% | 2.03% | 16.87% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/26/2025- NAV $82.70
- NAV Change $-1.03
- Market Price $82.74
- Market Price Change $-1.12
- Trading Volume (M) 6,664
- 30-Day Median Bid Ask Spread 0.25%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 12/26/2025- NAV $82.70
- NAV Change $-1.03
- Market Price $82.74
- Market Price Change $-1.12
- Trading Volume (M) 6,664
- 30-Day Median Bid Ask Spread 0.25%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 12/26/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.91% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,129,857.80 | 11,082 | 2931034 |
| 5.48% | GILD | GILEAD SCIENCES INC | -- | $4,759,799.00 | 38,170 | 2369174 |
| 5.33% | AMGN | AMGEN INC | -- | $4,629,724.58 | 13,906 | 2023607 |
| 4.12% | REGN | REGENERON PHARMACEUTICALS | -- | $3,581,033.14 | 4,562 | 2730190 |
| 2.76% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $2,395,705.20 | 25,788 | 2989044 |
| 2.69% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,337,442.65 | 5,835 | B00FWN1 |
| 1.93% | INSM | INSMED INC | -- | $1,675,629.60 | 9,420 | 2614487 |
| 1.32% | BIIB | BIOGEN INC | -- | $1,147,478.40 | 6,480 | 2455965 |
| 1.25% | ARGX | ARGENX SE - ADR | -- | $1,086,567.12 | 1,286 | BDVLM39 |
| 1.11% | UTHR | UNITED THERAPEUTICS CORP | -- | $964,618.32 | 1,902 | 2430412 |
| 1.05% | ILMN | ILLUMINA INC | -- | $910,777.55 | 6,749 | 2613990 |
| 1.00% | INCY | INCYTE CORP | -- | $868,053.81 | 8,671 | 2471950 |
| 0.85% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $740,120.62 | 18,871 | BMVP7Y0 |
| 0.81% | MEDP | MEDPACE HOLDINGS INC | -- | $706,044.64 | 1,244 | BDCBC61 |
| 0.79% | RVMD | REVOLUTION MEDICINES INC | -- | $689,524.25 | 8,539 | BL71K91 |
| 0.79% | ROIV | ROIVANT SCIENCES LTD | -- | $682,883.37 | 30,719 | BMW4NZ9 |
| 0.74% | BBIO | BRIDGEBIO PHARMA INC | -- | $645,209.60 | 8,512 | BK1KWG8 |
| 0.74% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $639,725.04 | 4,404 | 2623911 |
| 0.72% | VTRS | VIATRIS INC | -- | $626,496.64 | 50,852 | BMWS3X9 |
| 0.69% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $600,706.73 | 1,003 | BD59BS7 |
| 0.69% | SMMT | SUMMIT THERAPEUTICS INC | -- | $596,461.34 | 32,881 | BMTVQS7 |
| 0.68% | GH | GUARDANT HEALTH INC | -- | $588,427.72 | 5,714 | BFXC911 |
| 0.66% | IONS | IONIS PHARMACEUTICALS INC | -- | $571,819.22 | 7,154 | BDJ0LS6 |
| 0.65% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $566,753.76 | 2,712 | BV9G6B8 |
| 0.65% | SNY | SANOFI-ADR | -- | $566,517.36 | 11,688 | 2964557 |
| 0.63% | EXEL | EXELIXIS INC | -- | $547,574.08 | 11,842 | 2576941 |
| 0.62% | MRNA | MODERNA INC | -- | $538,231.20 | 17,251 | BGSXTS3 |
| 0.59% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $508,196.15 | 8,477 | 2437071 |
| 0.55% | RNA | AVIDITY BIOSCIENCES INC | -- | $480,025.15 | 6,655 | BMWHPY1 |
| 0.55% | TEM | TEMPUS AI INC | -- | $478,714.50 | 7,635 | BSLSJJ0 |
| 0.53% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $457,568.32 | 2,684 | B4Q5ZN4 |
| 0.50% | ONC | BEONE MEDICINES LTD-ADR | -- | $434,222.10 | 1,390 | BYYWPW6 |
| 0.49% | BNTX | BIONTECH SE-ADR | -- | $421,937.28 | 4,464 | BK6H543 |
| 0.48% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $420,889.84 | 5,999 | BYQBFJ8 |
| 0.43% | -- | ABIVAX SA ADR USD 0.01 | -- | $371,002.17 | 2,607 | -- |
| 0.42% | CYTK | CYTOKINETICS INC | -- | $360,547.43 | 5,713 | BBBSBJ5 |
| 0.41% | HALO | HALOZYME THERAPEUTICS INC | -- | $357,710.78 | 5,194 | 2975098 |
| 0.41% | -- | CARIS LIFE SCIENCES INC COMMON STOCK USD 0.001 | -- | $351,864.57 | 12,462 | -- |
| 0.39% | AXSM | AXSOME THERAPEUTICS INC | -- | $338,615.35 | 2,227 | BYZR4X4 |
| 0.38% | NUVL | NUVALENT INC-A | -- | $332,063.05 | 3,190 | BMVBZD3 |
| 0.37% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $324,280.00 | 2,948 | BF2YWG4 |
| 0.37% | KRYS | KRYSTAL BIOTECH INC | -- | $323,029.77 | 1,281 | BD6JX35 |
| 0.34% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $297,189.75 | 1,105 | BQ721R4 |
| 0.32% | PTCT | PTC THERAPEUTICS INC | -- | $278,573.76 | 3,546 | B17VCN9 |
| 0.31% | PCVX | VAXCYTE INC | -- | $271,768.42 | 5,786 | BKPVGH6 |
| 0.30% | COGT | COGENT BIOSCIENCES INC | -- | $263,489.76 | 6,777 | BLR6XK8 |
| 0.30% | KYMR | KYMERA THERAPEUTICS INC | -- | $258,434.96 | 3,178 | BMPRZV5 |
| 0.28% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $245,121.58 | 2,761 | BDCBCD8 |
| 0.27% | CRSP | CRISPR THERAPEUTICS AG | -- | $231,391.08 | 4,201 | BDHF4K6 |
| 0.24% | ALKS | ALKERMES PLC | -- | $207,863.04 | 7,296 | B3P6D26 |
| 0.24% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $206,404.26 | 7,473 | 2713317 |
| 0.24% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $205,789.02 | 4,506 | BFZQ0L8 |
| 0.23% | ADMA | ADMA BIOLOGICS INC | -- | $202,671.36 | 10,512 | B9NSBM2 |
| 0.23% | IMVT | IMMUNOVANT INC | -- | $202,478.40 | 7,740 | BJRFSB7 |
| 0.23% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $202,081.38 | 2,957 | BQS9486 |
| 0.23% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $201,000.36 | 4,191 | BDD19F8 |
| 0.23% | INDV | INDIVIOR PLC | -- | $199,698.15 | 5,515 | BP0BQQ5 |
| 0.22% | FOLD | AMICUS THERAPEUTICS INC | -- | $194,199.00 | 13,628 | B19FQ48 |
| 0.22% | APGE | APOGEE THERAPEUTICS INC | -- | $187,269.04 | 2,422 | BM9HHL5 |
| 0.21% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $179,920.20 | 2,270 | BJDX8Y8 |
| 0.21% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $179,746.00 | 13,880 | BFNF1D6 |
| 0.20% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $176,632.16 | 5,008 | BP8JSP4 |
| 0.20% | LGND | LIGAND PHARMACEUTICALS | -- | $170,176.27 | 869 | 2501578 |
| 0.19% | ACLX | ARCELLX INC | -- | $167,823.34 | 2,554 | BPCJ1Q2 |
| 0.19% | TERN | TERNS PHARMACEUTICALS INC | -- | $165,208.08 | 3,979 | BMDJ0C9 |
| 0.18% | GRAL | GRAIL INC | -- | $157,717.98 | 1,722 | BSLSSX7 |
| 0.18% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $156,727.70 | 5,410 | BKX9VD3 |
| 0.18% | TVTX | TRAVERE THERAPEUTICS INC | -- | $156,657.28 | 3,952 | BLFGJD5 |
| 0.18% | TARS | TARSUS PHARMACEUTICALS INC | -- | $153,337.50 | 1,875 | BMH5RL1 |
| 0.18% | XENE | XENON PHARMACEUTICALS INC | -- | $153,038.92 | 3,413 | BRJ3GY4 |
| 0.17% | VERA | VERA THERAPEUTICS INC | -- | $151,309.92 | 2,824 | BL55460 |
| 0.17% | VCYT | VERACYTE INC | -- | $148,587.53 | 3,497 | BFTWZY0 |
| 0.17% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $145,683.59 | 4,261 | BJ62Z18 |
| 0.16% | CGON | CG ONCOLOGY INC | -- | $141,790.56 | 3,559 | BRBCSP4 |
| 0.16% | APLS | APELLIS PHARMACEUTICALS INC | -- | $139,532.36 | 5,588 | BYTQ6X1 |
| 0.16% | IDYA | IDEAYA BIOSCIENCES INC | -- | $136,294.40 | 3,872 | BK0VHF6 |
| 0.15% | IRON | DISC MEDICINE INC | -- | $133,910.11 | 1,667 | BMGJZJ8 |
| 0.15% | WVE | WAVE LIFE SCIENCES LTD | -- | $131,213.68 | 7,384 | BYZG9R0 |
| 0.15% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $130,626.81 | 2,533 | B72ZBG4 |
| 0.15% | MLYS | MINERALYS THERAPEUTICS INC | -- | $129,841.44 | 3,496 | BP9N0G0 |
| 0.15% | DYN | DYNE THERAPEUTICS INC | -- | $126,412.32 | 6,308 | BN15WD1 |
| 0.14% | BEAM | BEAM THERAPEUTICS INC | -- | $125,406.36 | 4,482 | BK6L288 |
| 0.14% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $123,212.60 | 4,676 | BKY5JZ8 |
| 0.14% | OCUL | OCULAR THERAPEUTIX INC | -- | $118,139.36 | 9,406 | BNZB1X8 |
| 0.13% | SYRE | SPYRE THERAPEUTICS INC | -- | $112,885.38 | 3,427 | BQBBDY8 |
| 0.13% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $112,608.10 | 6,743 | BJ5FZ74 |
| 0.13% | DNLI | DENALI THERAPEUTICS INC | -- | $109,283.86 | 6,478 | BD2B4V0 |
| 0.12% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $107,931.13 | 4,261 | BLB0YQ9 |
| 0.12% | SRPT | SAREPTA THERAPEUTICS INC | -- | $102,128.04 | 4,617 | B8DPDT7 |
| 0.12% | ZBIO | ZENAS BIOPHARMA INC | -- | $100,743.79 | 2,371 | BQB42H3 |
| 0.11% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $97,002.72 | 2,544 | BKSGZN7 |
| 0.11% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $96,521.75 | 22,711 | BM9FJ13 |
| 0.11% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $94,623.75 | 5,823 | BFWLC09 |
| 0.11% | IBRX | IMMUNITYBIO INC | -- | $93,100.70 | 43,505 | BNSP0B8 |
| 0.10% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $91,123.02 | 3,474 | BMZ4LN0 |
| 0.10% | MAZE | MAZE THERAPEUTICS INC | -- | $89,462.50 | 2,125 | BSRK699 |
| 0.10% | TWST | TWIST BIOSCIENCE CORP | -- | $89,201.95 | 2,699 | BGKG6G7 |
| 0.10% | ZYME | ZYMEWORKS INC | -- | $88,805.35 | 3,305 | BPCQZY9 |
| 0.10% | NRIX | NURIX THERAPEUTICS INC | -- | $86,406.10 | 4,477 | BMVLGP2 |
| 0.10% | GMAB | GENMAB A/S -SP ADR | -- | $86,290.44 | 2,582 | BBC9WC7 |
| 0.10% | SION | SIONNA THERAPEUTICS INC | -- | $86,132.70 | 1,971 | BQKXDX4 |
| 0.10% | TXG | 10X GENOMICS INC-CLASS A | -- | $84,857.54 | 5,146 | BKS3RS7 |
| 0.10% | VCEL | VERICEL CORP | -- | $84,132.44 | 2,234 | BSBMN89 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $83,790.00 | 1,995 | BRXB0C0 |
| 0.10% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $83,789.07 | 3,719 | BMX9K07 |
| 0.09% | HROW | HARROW INC | -- | $81,947.24 | 1,636 | BHNDW86 |
| 0.09% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $81,770.70 | 3,839 | BN7Q7R7 |
| 0.09% | ANIP | ANI PHARMACEUTICALS INC | -- | $81,750.72 | 992 | BCDWBX6 |
| 0.09% | STOK | STOKE THERAPEUTICS INC | -- | $80,534.16 | 2,523 | BJQ05Z6 |
| 0.09% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $79,776.06 | 5,187 | BRJZSK0 |
| 0.09% | MNKD | MANNKIND CORP | -- | $78,529.77 | 13,563 | BF081J4 |
| 0.08% | -- | PHARVARIS NV COMMON STOCK USD 0.12 | -- | $72,875.04 | 2,829 | -- |
| 0.08% | TRVI | TREVI THERAPEUTICS INC | -- | $72,782.40 | 5,664 | BJH9ZN0 |
| 0.08% | ALVO | ALVOTECH SA | -- | $72,724.76 | 13,826 | BPNTJ34 |
| 0.08% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $72,179.52 | 2,576 | BCBVTX1 |
| 0.08% | FTRE | FORTREA HOLDINGS INC | -- | $71,009.40 | 4,081 | BRXYZ57 |
| 0.08% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $70,951.37 | 9,299 | 2100362 |
| 0.08% | TSHA | TAYSHA GENE THERAPIES INC | -- | $70,537.17 | 12,099 | BNC1BX1 |
| 0.08% | UPB | UPSTREAM BIO INC | -- | $70,368.76 | 2,387 | BRCFFK6 |
| 0.08% | KOD | KODIAK SCIENCES INC | -- | $70,032.27 | 2,343 | BFXC933 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $69,622.51 | 1,927 | BLCD809 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $69,576.64 | 1,396 | BX7RSN3 |
| 0.08% | QURE | UNIQURE NV | -- | $68,252.31 | 2,751 | BJFSR88 |
| 0.08% | ORKA | ORUKA THERAPEUTICS INC | -- | $67,774.60 | 2,138 | BKVF0J2 |
| 0.08% | EYPT | EYEPOINT INC | -- | $66,886.53 | 3,657 | BMGS7L1 |
| 0.08% | NVCR | NOVOCURE LTD | -- | $66,672.08 | 4,946 | BYSS4X4 |
| 0.08% | RLAY | RELAY THERAPEUTICS INC | -- | $65,526.80 | 7,655 | BN2R582 |
| 0.08% | INVA | INNOVIVA INC | -- | $65,399.40 | 3,303 | BDDXF67 |
| 0.08% | ATAI | ATAI LIFE SCIENCES NV | -- | $65,290.94 | 16,042 | BN6M8F1 |
| 0.07% | PGEN | PRECIGEN INC | -- | $64,866.88 | 15,593 | BKM5C84 |
| 0.07% | RAPP | RAPPORT THERAPEUTICS INC | -- | $63,631.40 | 2,107 | BR3T9B6 |
| 0.07% | ARDX | ARDELYX INC | -- | $61,601.68 | 10,732 | BN89V40 |
| 0.07% | MBX | MBX BIOSCIENCES INC | -- | $61,274.70 | 1,983 | BQXJKH2 |
| 0.07% | ANAB | ANAPTYSBIO INC | -- | $61,272.30 | 1,223 | BDRW1L7 |
| 0.07% | TYRA | TYRA BIOSCIENCES INC | -- | $61,187.72 | 2,357 | BMVNDH9 |
| 0.07% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $59,812.83 | 4,851 | BPCK358 |
| 0.07% | SVRA | SAVARA INC | -- | $57,966.15 | 8,987 | BYXGN81 |
| 0.07% | MNMD | MIND MEDICINE MINDMED INC | -- | $56,824.06 | 4,351 | BPQYY97 |
| 0.07% | SEPN | SEPTERNA INC | -- | $56,610.36 | 1,978 | BQNKXX2 |
| 0.06% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $55,173.52 | 3,142 | BJLKVS6 |
| 0.06% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $55,053.60 | 2,030 | BNFWZS4 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $54,014.73 | 7,329 | BLR7H87 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $51,883.65 | 11,765 | BMFJJ97 |
| 0.06% | TNGX | TANGO THERAPEUTICS INC | -- | $51,577.83 | 5,949 | BP2P6L0 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $51,494.82 | 642 | BNSP8K3 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $50,780.16 | 1,289 | BKLCWZ3 |
| 0.06% | PCRX | PACIRA BIOSCIENCES INC | -- | $50,369.00 | 1,900 | B3X26D8 |
| 0.06% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $49,971.90 | 17,534 | BF0DMK7 |
| 0.06% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $49,726.04 | 2,876 | BP7KZP7 |
| 0.06% | SPRY | ARS PHARMACEUTICALS INC | -- | $49,685.08 | 4,366 | BMCR7V2 |
| 0.06% | OMER | OMEROS CORP | -- | $49,203.72 | 3,132 | B4NB858 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $49,030.80 | 5,388 | B8K7T65 |
| 0.06% | NVAX | NOVAVAX INC | -- | $49,018.91 | 7,177 | BJDQXG4 |
| 0.06% | NTLA | INTELLIA THERAPEUTICS INC | -- | $48,247.84 | 5,111 | BYZM6C2 |
| 0.06% | XNCR | XENCOR INC | -- | $48,003.88 | 3,154 | BGCYWN8 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $47,626.04 | 2,068 | BZ7PJQ1 |
| 0.05% | ABCL | ABCELLERA BIOLOGICS INC | -- | $47,399.20 | 13,240 | BL53SR3 |
| 0.05% | ALMS | ALUMIS INC | -- | $47,105.18 | 4,294 | BPLQG36 |
| 0.05% | ERAS | ERASCA INC | -- | $43,607.88 | 12,531 | BNLYBF3 |
| 0.05% | CRMD | CORMEDIX INC | -- | $43,604.40 | 3,480 | BJ0LT31 |
| 0.05% | -- | RAPT THERAPEUTICS INC | -- | $43,354.08 | 1,224 | BTJZB49 |
| 0.05% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $42,722.30 | 2,621 | BMFD115 |
| 0.05% | ESPR | ESPERION THERAPEUTICS INC | -- | $42,658.36 | 10,559 | BBNBTD2 |
| 0.05% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $42,610.05 | 4,509 | BLB0YH0 |
| 0.05% | MESO | MESOBLAST LTD- SPON ADR | -- | $42,237.00 | 2,166 | BQS7491 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $42,182.76 | 2,239 | BMNDK09 |
| 0.05% | KURA | KURA ONCOLOGY INC | -- | $40,776.68 | 3,836 | BYZD465 |
| 0.05% | BCAX | BICARA THERAPEUTICS INC | -- | $40,656.00 | 2,420 | BQB42F1 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $40,606.10 | 8,495 | BZ0QMB7 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $40,051.31 | 1,823 | BMGTLY5 |
| 0.04% | GERN | GERON CORP | -- | $38,628.52 | 28,196 | 2370381 |
| 0.04% | JANX | JANUX THERAPEUTICS INC | -- | $37,862.25 | 2,657 | BMFX8Y7 |
| 0.04% | VIR | VIR BIOTECHNOLOGY INC | -- | $36,870.00 | 6,145 | BK4PZ38 |
| 0.04% | ORIC | ORIC PHARMACEUTICALS INC | -- | $35,491.50 | 4,302 | BKVDFF7 |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $35,296.02 | 802 | BQD3J33 |
| 0.04% | -- | GH RESEARCH PLC COMMON STOCK USD 0.01 | -- | $34,524.00 | 2,740 | -- |
| 0.04% | REPL | REPLIMUNE GROUP INC | -- | $34,511.40 | 3,465 | BDDVW37 |
| 0.04% | ARVN | ARVINAS INC | -- | $34,497.92 | 2,837 | BDZ30Q0 |
| 0.04% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $34,467.51 | 903 | BL95N25 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $33,874.61 | 2,233 | BD06CS0 |
| 0.04% | LXEO | LEXEO THERAPEUTICS INC | -- | $33,046.00 | 3,224 | BQ6C357 |
| 0.04% | GOSS | GOSSAMER BIO INC | -- | $33,020.29 | 10,223 | BJ0CK86 |
| 0.04% | IVVD | INVIVYD INC | -- | $32,925.60 | 12,240 | BM8NHS1 |
| 0.04% | LYEL | LYELL IMMUNOPHARMA INC | -- | $32,879.33 | 937 | BTNMG41 |
| 0.04% | CTMX | CYTOMX THERAPEUTICS INC | -- | $32,854.76 | 7,484 | BYWVTY5 |
| 0.04% | ANNX | ANNEXON INC | -- | $32,668.23 | 6,393 | BMVV9R5 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $32,280.11 | 5,389 | BYVQJ96 |
| 0.04% | PSNL | PERSONALIS INC | -- | $31,892.52 | 3,918 | BJQ0608 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $31,692.57 | 1,729 | BD9GVY0 |
| 0.04% | RGNX | REGENXBIO INC | -- | $31,661.76 | 2,236 | BZ0G875 |
| 0.03% | VTYX | VENTYX BIOSCIENCES INC | -- | $29,187.52 | 3,152 | BMG99Y1 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $28,333.35 | 3,555 | BFYQFJ2 |
| 0.03% | KROS | KEROS THERAPEUTICS INC | -- | $28,306.38 | 1,346 | BM7V485 |
| 0.03% | PRME | PRIME MEDICINE INC | -- | $27,905.50 | 7,973 | BPBJFM7 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $27,802.16 | 4,162 | BMC3HS7 |
| 0.03% | FULC | FULCRUM THERAPEUTICS INC | -- | $27,676.20 | 2,390 | BJDX8Z9 |
| 0.03% | CGEM | CULLINAN THERAPEUTICS INC | -- | $27,055.33 | 2,609 | BM90J52 |
| 0.03% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $25,402.30 | 3,299 | BYP80F1 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $24,229.08 | 2,516 | BMFK3H6 |
| 0.03% | ABSI | ABSCI CORP | -- | $23,711.94 | 6,642 | BN94K69 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $23,602.95 | 13,335 | B4N8MH9 |
| 0.03% | LENZ | LENZ THERAPEUTICS INC | -- | $23,314.34 | 1,382 | BQV0J03 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $22,992.00 | 7,185 | B3MZ6K5 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $22,686.12 | 2,378 | B91XRN2 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $22,059.69 | 2,487 | BLFBZ32 |
| 0.03% | BIOA | BIOAGE LABS INC | -- | $21,985.92 | 1,584 | BT9K6D8 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $21,483.75 | 1,275 | B9L5200 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $21,106.17 | 639 | B292NQ7 |
| 0.02% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $20,947.62 | 6,406 | BMCWKZ2 |
| 0.02% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $20,116.28 | 2,524 | BKLXFX5 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $20,095.44 | 3,441 | BQHN6C7 |
| 0.02% | ETON | ETON PHARMACEUTICALS INC | -- | $19,943.55 | 1,185 | BGL0JK3 |
| 0.02% | IMAB | I-MAB-SPONSORED ADR | -- | $19,929.28 | 4,592 | BKRRKY7 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $19,832.01 | 3,163 | 2107437 |
| 0.02% | EOLS | EVOLUS INC | -- | $19,754.70 | 2,863 | BDRJH21 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $19,193.96 | 2,852 | BMVBZF5 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $18,374.40 | 2,610 | B12W3P6 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $18,226.60 | 1,939 | BSMLR16 |
| 0.02% | KMDA | KAMADA LTD | -- | $18,014.36 | 2,548 | B2Q9833 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $17,790.74 | 4,609 | BFY7DC4 |
| 0.02% | PEPG | PEPGEN INC | -- | $17,644.97 | 3,037 | BMTX3D7 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $17,572.08 | 1,688 | BP81RK8 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $17,267.76 | 827 | BPBPCG8 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $16,634.40 | 4,780 | BDFKQ07 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $16,465.35 | 2,805 | BP81R42 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $14,855.40 | 3,780 | BMXNGZ6 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $14,796.20 | 8,860 | BFMLGR4 |
| 0.02% | CADL | CANDEL THERAPEUTICS INC | -- | $14,574.25 | 2,425 | BP0TQC5 |
| 0.02% | ACRS | ACLARIS THERAPEUTICS INC | -- | $14,501.58 | 4,786 | BYV2W40 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $14,363.44 | 3,946 | BYTYP72 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $13,940.08 | 2,044 | BKDQKM6 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $13,881.55 | 4,435 | BZC0D70 |
| 0.02% | LFCR | LIFECORE BIOMEDICAL INC | -- | $13,736.50 | 1,655 | 2517058 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $13,712.16 | 2,226 | B7F2TY6 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $13,697.88 | 9,926 | BFZNYB7 |
| 0.02% | NGNE | NEUROGENE INC | -- | $13,686.84 | 684 | BS2F741 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $13,489.20 | 2,498 | BMF7DT9 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $13,136.40 | 7,380 | BN4JN37 |
| 0.02% | AARD | AARDVARK THERAPEUTICS INC | -- | $13,131.30 | 962 | BTXQTX3 |
| 0.01% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $12,858.80 | 2,074 | BL5B6Z1 |
| 0.01% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $12,658.20 | 1,020 | BPRBTY7 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $12,596.15 | 3,451 | BLN9Z50 |
| 0.01% | OABI | OMNIAB INC | -- | $12,270.94 | 6,358 | BN13S71 |
| 0.01% | -- | VOR BIOPHARMA INC COMMON STOCK USD 0.0001 | -- | $10,951.68 | 744 | -- |
| 0.01% | -- | JYONG BIOTECH LTD COMMON STOCK USD 0.00001 | -- | $10,812.76 | 3,358 | -- |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $10,774.08 | 2,494 | BPRB2N7 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $10,632.48 | 2,606 | BY7RB53 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $10,623.51 | 8,637 | BNR5QT9 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $9,550.56 | 2,364 | BP7L561 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $9,357.04 | 4,312 | BZ8FPH3 |
| 0.01% | CABA | CABALETTA BIO INC | -- | $9,311.88 | 4,252 | BK5MWR1 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $9,075.72 | 4,281 | BKX9NQ0 |
| 0.01% | HUMA | HUMACYTE INC | -- | $8,851.04 | 8,272 | BMYTJP4 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $8,159.24 | 1,369 | BP2NYN2 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $7,730.80 | 1,255 | BKC9SX3 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $7,100.87 | 5,339 | BRK0149 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $7,017.60 | 4,128 | BNYJR68 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $6,519.03 | 2,517 | BKTV702 |
| 0.01% | CDXS | CODEXIS INC | -- | $6,503.70 | 3,990 | B5LL2C2 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $6,031.20 | 4,308 | BNNXX18 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $5,545.65 | 7,354 | BNNXX52 |
| -- | PYXS | PYXIS ONCOLOGY INC | -- | $3,052.50 | 2,750 | BLBR8D5 |
| -- | -- | SUTRO BIOPHARMA INC COMMON STOCK USD 0.001 | -- | $11.49 | 01 | -- |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| 36.87% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 32,014,777 | -- | 5,511 | -- |
| 32.63% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 28,337,522 | -- | 4,878 | -- |
| 25.12% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 21,813,734 | -- | 3,755 | -- |
| 16.62% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,430,177 | -- | 2,484 | -- |
| 15.38% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 13,355,466 | -- | 2,299 | -- |
| 4.23% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,677,255 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $26,896,085.94 | 26,896,086 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
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