BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 12/31/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 1/14/2026- NAV $83.22
- NAV Change $+1.85
- Market Price $83.18
- Market Price Change $+1.82
- Trading Volume (M) 5,938
- 30-Day Median Bid Ask Spread 0.26%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 1/14/2026- NAV $83.22
- NAV Change $+1.85
- Market Price $83.18
- Market Price Change $+1.82
- Trading Volume (M) 5,938
- 30-Day Median Bid Ask Spread 0.26%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 12/31/2025
Holdings
as of 1/14/2026
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.72% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,049,570.49 | 11,233 | 2931034 |
| 5.44% | GILD | GILEAD SCIENCES INC | -- | $4,800,516.44 | 38,692 | 2369174 |
| 5.26% | AMGN | AMGEN INC | -- | $4,637,161.12 | 14,096 | 2023607 |
| 3.95% | REGN | REGENERON PHARMACEUTICALS | -- | $3,487,143.36 | 4,624 | 2730190 |
| 2.86% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $2,518,423.94 | 26,141 | 2989044 |
| 2.46% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,169,976.90 | 5,915 | B00FWN1 |
| 1.77% | INSM | INSMED INC | -- | $1,560,879.54 | 9,549 | 2614487 |
| 1.26% | BIIB | BIOGEN INC | -- | $1,112,197.39 | 6,569 | 2455965 |
| 1.19% | RVMD | REVOLUTION MEDICINES INC | -- | $1,049,280.32 | 8,656 | BL71K91 |
| 1.18% | ARGX | ARGENX SE - ADR | -- | $1,042,326.32 | 1,304 | BDVLM39 |
| 1.12% | ILMN | ILLUMINA INC | -- | $984,898.77 | 6,841 | 2613990 |
| 1.06% | INCY | INCYTE CORP | -- | $931,300.50 | 8,790 | 2471950 |
| 1.04% | UTHR | UNITED THERAPEUTICS CORP | -- | $917,207.44 | 1,928 | 2430412 |
| 0.88% | MEDP | MEDPACE HOLDINGS INC | -- | $777,343.45 | 1,261 | BDCBC61 |
| 0.87% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $769,177.09 | 19,129 | BMVP7Y0 |
| 0.84% | ROIV | ROIVANT SCIENCES LTD | -- | $741,419.59 | 31,139 | BMW4NZ9 |
| 0.80% | MRNA | MODERNA INC | -- | $709,622.46 | 17,487 | BGSXTS3 |
| 0.77% | VTRS | VIATRIS INC | -- | $677,856.20 | 51,548 | BMWS3X9 |
| 0.76% | BBIO | BRIDGEBIO PHARMA INC | -- | $672,121.20 | 8,628 | BK1KWG8 |
| 0.71% | GH | GUARDANT HEALTH INC | -- | $629,011.20 | 5,792 | BFXC911 |
| 0.68% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $604,113.12 | 4,464 | 2623911 |
| 0.68% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $597,412.68 | 2,749 | BV9G6B8 |
| 0.67% | SMMT | SUMMIT THERAPEUTICS INC | -- | $588,292.15 | 33,331 | BMTVQS7 |
| 0.65% | IONS | IONIS PHARMACEUTICALS INC | -- | $571,965.24 | 7,252 | BDJ0LS6 |
| 0.64% | SNY | SANOFI-ADR | -- | $567,400.72 | 11,848 | 2964557 |
| 0.62% | EXEL | EXELIXIS INC | -- | $542,940.92 | 12,004 | 2576941 |
| 0.61% | TEM | TEMPUS AI INC | -- | $536,157.92 | 7,739 | BSLSJJ0 |
| 0.58% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $513,818.91 | 1,017 | BD59BS7 |
| 0.56% | BNTX | BIONTECH SE-ADR | -- | $493,768.00 | 4,525 | BK6H543 |
| 0.55% | RNA | AVIDITY BIOSCIENCES INC | -- | $489,354.84 | 6,746 | BMWHPY1 |
| 0.55% | ONC | BEONE MEDICINES LTD-ADR | -- | $488,570.75 | 1,409 | BYYWPW6 |
| 0.55% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $481,895.44 | 8,593 | 2437071 |
| 0.53% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $464,774.01 | 2,721 | B4Q5ZN4 |
| 0.45% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $400,798.71 | 6,081 | BYQBFJ8 |
| 0.45% | AXSM | AXSOME THERAPEUTICS INC | -- | $399,511.57 | 2,257 | BYZR4X4 |
| 0.44% | HALO | HALOZYME THERAPEUTICS INC | -- | $384,134.40 | 5,265 | 2975098 |
| 0.43% | KRYS | KRYSTAL BIOTECH INC | -- | $379,035.21 | 1,299 | BD6JX35 |
| 0.42% | CYTK | CYTOKINETICS INC | -- | $373,840.20 | 5,787 | BBBSBJ5 |
| 0.40% | NUVL | NUVALENT INC-A | -- | $348,754.56 | 3,234 | BMVBZD3 |
| 0.38% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $338,659.92 | 2,988 | BF2YWG4 |
| 0.38% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $334,275.20 | 1,120 | BQ721R4 |
| 0.38% | CAI | CARIS LIFE SCIENCES INC | -- | $333,737.44 | 12,632 | BT18HP9 |
| 0.37% | ABVX | ABIVAX SA-ADR | -- | $330,401.43 | 2,643 | BLC89B2 |
| 0.32% | PCVX | VAXCYTE INC | -- | $284,511.15 | 5,865 | BKPVGH6 |
| 0.31% | PTCT | PTC THERAPEUTICS INC | -- | $277,780.26 | 3,594 | B17VCN9 |
| 0.29% | COGT | COGENT BIOSCIENCES INC | -- | $259,617.30 | 6,870 | BLR6XK8 |
| 0.29% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $252,737.01 | 2,997 | BQS9486 |
| 0.27% | CRSP | CRISPR THERAPEUTICS AG | -- | $242,294.51 | 4,259 | BDHF4K6 |
| 0.27% | KYMR | KYMERA THERAPEUTICS INC | -- | $242,251.41 | 3,221 | BMPRZV5 |
| 0.27% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $238,558.77 | 2,799 | BDCBCD8 |
| 0.27% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $235,424.16 | 4,248 | BDD19F8 |
| 0.26% | ALKS | ALKERMES PLC | -- | $226,465.52 | 7,396 | B3P6D26 |
| 0.24% | IMVT | IMMUNOVANT INC | -- | $214,588.10 | 7,846 | BJRFSB7 |
| 0.24% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $208,585.65 | 2,301 | BJDX8Y8 |
| 0.24% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $208,209.44 | 4,568 | BFZQ0L8 |
| 0.23% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $203,464.50 | 7,575 | 2713317 |
| 0.23% | APGE | APOGEE THERAPEUTICS INC | -- | $202,365.65 | 2,455 | BM9HHL5 |
| 0.23% | CGON | CG ONCOLOGY INC | -- | $200,280.08 | 3,608 | BRBCSP4 |
| 0.23% | FOLD | AMICUS THERAPEUTICS INC | -- | $198,645.32 | 13,814 | B19FQ48 |
| 0.22% | ADMA | ADMA BIOLOGICS INC | -- | $194,791.68 | 10,656 | B9NSBM2 |
| 0.21% | INDV | INDIVIOR PLC | -- | $187,991.70 | 5,590 | BP0BQQ5 |
| 0.21% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $186,427.50 | 14,070 | BFNF1D6 |
| 0.21% | GRAL | GRAIL INC | -- | $182,893.50 | 1,746 | BSLSSX7 |
| 0.21% | ACLX | ARCELLX INC | -- | $180,867.54 | 2,589 | BPCJ1Q2 |
| 0.20% | LGND | LIGAND PHARMACEUTICALS | -- | $173,151.74 | 881 | 2501578 |
| 0.18% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $162,025.92 | 5,076 | BP8JSP4 |
| 0.18% | BEAM | BEAM THERAPEUTICS INC | -- | $160,867.63 | 4,543 | BK6L288 |
| 0.17% | VCYT | VERACYTE INC | -- | $150,485.25 | 3,545 | BFTWZY0 |
| 0.17% | TERN | TERNS PHARMACEUTICALS INC | -- | $149,946.94 | 4,033 | BMDJ0C9 |
| 0.17% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $146,587.32 | 5,484 | BKX9VD3 |
| 0.16% | IDYA | IDEAYA BIOSCIENCES INC | -- | $145,342.75 | 3,925 | BK0VHF6 |
| 0.16% | XENE | XENON PHARMACEUTICALS INC | -- | $143,866.80 | 3,460 | BRJ3GY4 |
| 0.16% | TARS | TARSUS PHARMACEUTICALS INC | -- | $143,012.23 | 1,901 | BMH5RL1 |
| 0.16% | VERA | VERA THERAPEUTICS INC | -- | $138,597.83 | 2,863 | BL55460 |
| 0.15% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $133,525.80 | 4,740 | BKY5JZ8 |
| 0.15% | IBRX | IMMUNITYBIO INC | -- | $133,182.00 | 44,100 | BNSP0B8 |
| 0.15% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $133,022.40 | 2,568 | B72ZBG4 |
| 0.15% | IRON | DISC MEDICINE INC | -- | $130,265.20 | 1,690 | BMGJZJ8 |
| 0.14% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $123,303.40 | 6,835 | BJ5FZ74 |
| 0.14% | DNLI | DENALI THERAPEUTICS INC | -- | $119,979.09 | 6,567 | BD2B4V0 |
| 0.13% | MLYS | MINERALYS THERAPEUTICS INC | -- | $118,422.76 | 3,544 | BP9N0G0 |
| 0.13% | TVTX | TRAVERE THERAPEUTICS INC | -- | $115,893.58 | 4,006 | BLFGJD5 |
| 0.13% | SYRE | SPYRE THERAPEUTICS INC | -- | $115,197.84 | 3,474 | BQBBDY8 |
| 0.13% | APLS | APELLIS PHARMACEUTICALS INC | -- | $115,149.12 | 5,664 | BYTQ6X1 |
| 0.13% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $111,656.70 | 23,022 | BM9FJ13 |
| 0.13% | DYN | DYNE THERAPEUTICS INC | -- | $111,575.30 | 6,394 | BN15WD1 |
| 0.12% | TWST | TWIST BIOSCIENCE CORP | -- | $109,522.08 | 2,736 | BGKG6G7 |
| 0.12% | TXG | 10X GENOMICS INC-CLASS A | -- | $109,118.72 | 5,216 | BKS3RS7 |
| 0.12% | WVE | WAVE LIFE SCIENCES LTD | -- | $108,607.35 | 7,485 | BYZG9R0 |
| 0.12% | SRPT | SAREPTA THERAPEUTICS INC | -- | $106,704.00 | 4,680 | B8DPDT7 |
| 0.12% | ALMS | ALUMIS INC | -- | $105,952.02 | 4,353 | BPLQG36 |
| 0.12% | ERAS | ERASCA INC | -- | $105,553.62 | 12,702 | BNLYBF3 |
| 0.12% | OCUL | OCULAR THERAPEUTIX INC | -- | $105,552.45 | 9,535 | BNZB1X8 |
| 0.12% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $103,958.33 | 4,319 | BJ62Z18 |
| 0.11% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $101,327.94 | 3,522 | BMZ4LN0 |
| 0.11% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $95,406.71 | 4,319 | BLB0YQ9 |
| 0.11% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $92,947.16 | 2,579 | BKSGZN7 |
| 0.10% | GMAB | GENMAB A/S -SP ADR | -- | $92,484.78 | 2,617 | BBC9WC7 |
| 0.10% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $89,902.69 | 5,903 | BFWLC09 |
| 0.10% | MAZE | MAZE THERAPEUTICS INC | -- | $88,550.94 | 2,154 | BSRK699 |
| 0.10% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $87,765.60 | 3,770 | BMX9K07 |
| 0.10% | MBX | MBX BIOSCIENCES INC | -- | $86,409.90 | 2,010 | BQXJKH2 |
| 0.10% | NRIX | NURIX THERAPEUTICS INC | -- | $86,403.52 | 4,538 | BMVLGP2 |
| 0.10% | ANIP | ANI PHARMACEUTICALS INC | -- | $85,540.18 | 1,006 | BCDWBX6 |
| 0.10% | VCEL | VERICEL CORP | -- | $84,552.45 | 2,265 | BSBMN89 |
| 0.09% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $83,423.04 | 3,891 | BN7Q7R7 |
| 0.09% | ZYME | ZYMEWORKS INC | -- | $82,477.00 | 3,350 | BPCQZY9 |
| 0.09% | SION | SIONNA THERAPEUTICS INC | -- | $82,277.64 | 1,998 | BQKXDX4 |
| 0.09% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $82,024.80 | 5,258 | BRJZSK0 |
| 0.09% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $79,990.32 | 2,022 | BRXB0C0 |
| 0.09% | HROW | HARROW INC | -- | $79,849.28 | 1,658 | BHNDW86 |
| 0.09% | STOK | STOKE THERAPEUTICS INC | -- | $79,190.29 | 2,557 | BJQ05Z6 |
| 0.09% | UPB | UPSTREAM BIO INC | -- | $78,166.00 | 2,420 | BRCFFK6 |
| 0.09% | MNKD | MANNKIND CORP | -- | $77,126.28 | 13,748 | BF081J4 |
| 0.09% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $75,014.03 | 2,611 | BCBVTX1 |
| 0.08% | ARDX | ARDELYX INC | -- | $74,956.31 | 10,879 | BN89V40 |
| 0.08% | TNGX | TANGO THERAPEUTICS INC | -- | $74,711.70 | 6,030 | BP2P6L0 |
| 0.08% | PHVS | PHARVARIS NV | -- | $73,506.84 | 2,868 | BMZ2X38 |
| 0.08% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $70,134.90 | 2,915 | BP7KZP7 |
| 0.08% | ALVO | ALVOTECH SA | -- | $70,075.00 | 14,015 | BPNTJ34 |
| 0.08% | TYRA | TYRA BIOSCIENCES INC | -- | $69,758.80 | 2,389 | BMVNDH9 |
| 0.08% | PGEN | PRECIGEN INC | -- | $69,708.87 | 15,807 | BKM5C84 |
| 0.08% | FTRE | FORTREA HOLDINGS INC | -- | $69,377.49 | 4,137 | BRXYZ57 |
| 0.08% | ORKA | ORUKA THERAPEUTICS INC | -- | $69,344.00 | 2,167 | BKVF0J2 |
| 0.08% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $69,214.85 | 2,657 | BMFD115 |
| 0.08% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $69,182.19 | 4,917 | BPCK358 |
| 0.08% | NVCR | NOVOCURE LTD | -- | $69,042.78 | 5,014 | BYSS4X4 |
| 0.08% | KOD | KODIAK SCIENCES INC | -- | $68,091.25 | 2,375 | BFXC933 |
| 0.08% | -- | MIND MEDICINE (MINDMED) INC | -- | $66,238.20 | 4,410 | -- |
| 0.07% | INVA | INNOVIVA INC | -- | $66,089.52 | 3,348 | BDDXF67 |
| 0.07% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $65,896.55 | 1,415 | BX7RSN3 |
| 0.07% | TRVI | TREVI THERAPEUTICS INC | -- | $65,677.04 | 5,741 | BJH9ZN0 |
| 0.07% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $64,702.89 | 1,953 | BLCD809 |
| 0.07% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $63,908.28 | 9,426 | 2100362 |
| 0.07% | RLAY | RELAY THERAPEUTICS INC | -- | $62,623.20 | 7,760 | BN2R582 |
| 0.07% | QURE | UNIQURE NV | -- | $62,334.15 | 2,789 | BJFSR88 |
| 0.07% | ANAB | ANAPTYSBIO INC | -- | $62,322.40 | 1,240 | BDRW1L7 |
| 0.07% | NTLA | INTELLIA THERAPEUTICS INC | -- | $62,275.62 | 5,181 | BYZM6C2 |
| 0.07% | TSHA | TAYSHA GENE THERAPIES INC | -- | $61,810.56 | 12,264 | BNC1BX1 |
| 0.07% | ATAI | ATAIBECKLEY INC | -- | $60,490.92 | 16,261 | BWJDYK1 |
| 0.07% | NVAX | NOVAVAX INC | -- | $59,582.25 | 7,275 | BJDQXG4 |
| 0.07% | EYPT | EYEPOINT INC | -- | $59,015.44 | 3,707 | BMGS7L1 |
| 0.07% | RAPP | RAPPORT THERAPEUTICS INC | -- | $58,569.12 | 2,136 | BR3T9B6 |
| 0.07% | ABCL | ABCELLERA BIOLOGICS INC | -- | $57,576.09 | 13,421 | BL53SR3 |
| 0.06% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $57,130.08 | 2,058 | BNFWZS4 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $56,529.24 | 11,926 | BMFJJ97 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $56,311.82 | 7,429 | BLR7H87 |
| 0.06% | SVRA | SAVARA INC | -- | $54,660.00 | 9,110 | BYXGN81 |
| 0.06% | ZBIO | ZENAS BIOPHARMA INC | -- | $54,211.68 | 2,403 | BQB42H3 |
| 0.06% | SEPN | SEPTERNA INC | -- | $53,593.65 | 2,005 | BQNKXX2 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $53,286.39 | 1,307 | BKLCWZ3 |
| 0.06% | SPRY | ARS PHARMACEUTICALS INC | -- | $52,182.54 | 4,426 | BMCR7V2 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $50,468.88 | 5,462 | B8K7T65 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $49,430.43 | 651 | BNSP8K3 |
| 0.06% | ORIC | ORIC PHARMACEUTICALS INC | -- | $49,061.25 | 4,361 | BKVDFF7 |
| 0.06% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $49,046.83 | 4,571 | BLB0YH0 |
| 0.05% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $48,220.90 | 3,185 | BJLKVS6 |
| 0.05% | GHRS | GH RESEARCH PLC | -- | $46,959.07 | 2,777 | BP6C0S2 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $46,784.70 | 2,270 | BMNDK09 |
| 0.05% | XNCR | XENCOR INC | -- | $46,196.65 | 3,197 | BGCYWN8 |
| 0.05% | VTYX | VENTYX BIOSCIENCES INC | -- | $44,282.70 | 3,195 | BMG99Y1 |
| 0.05% | BCAX | BICARA THERAPEUTICS INC | -- | $44,203.06 | 2,453 | BQB42F1 |
| 0.05% | ANNX | ANNEXON INC | -- | $43,286.40 | 6,480 | BMVV9R5 |
| 0.05% | RAPT | RAPT THERAPEUTICS INC | -- | $43,099.93 | 1,241 | BTJZB49 |
| 0.05% | PCRX | PACIRA BIOSCIENCES INC | -- | $42,834.24 | 1,926 | B3X26D8 |
| 0.05% | VIR | VIR BIOTECHNOLOGY INC | -- | $42,481.78 | 6,229 | BK4PZ38 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $42,302.12 | 17,774 | BF0DMK7 |
| 0.05% | OMER | OMEROS CORP | -- | $41,529.00 | 3,175 | B4NB858 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $41,524.56 | 1,848 | BMGTLY5 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $41,160.58 | 8,611 | BZ0QMB7 |
| 0.04% | URGN | UROGEN PHARMA LTD | -- | $39,279.04 | 2,096 | BZ7PJQ1 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $38,737.44 | 2,196 | BQS7491 |
| 0.04% | GERN | GERON CORP | -- | $38,585.70 | 28,582 | 2370381 |
| 0.04% | JANX | JANUX THERAPEUTICS INC | -- | $38,025.16 | 2,693 | BMFX8Y7 |
| 0.04% | PSNL | PERSONALIS INC | -- | $36,939.60 | 3,972 | BJQ0608 |
| 0.04% | BIOA | BIOAGE LABS INC | -- | $36,809.52 | 1,606 | BT9K6D8 |
| 0.04% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $36,481.05 | 915 | BL95N25 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $36,401.04 | 3,889 | BYZD465 |
| 0.04% | ARVN | ARVINAS INC | -- | $35,087.20 | 2,876 | BDZ30Q0 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $34,833.42 | 8,082 | BPBJFM7 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $34,570.69 | 10,703 | BBNBTD2 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $34,503.36 | 2,264 | BD06CS0 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $34,376.33 | 1,753 | BD9GVY0 |
| 0.04% | RGNX | REGENXBIO INC | -- | $33,891.65 | 2,267 | BZ0G875 |
| 0.04% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $33,064.82 | 7,283 | B3MZ6K5 |
| 0.04% | CTMX | CYTOMX THERAPEUTICS INC | -- | $32,619.80 | 7,586 | BYWVTY5 |
| 0.04% | IVVD | INVIVYD INC | -- | $32,258.20 | 12,407 | BM8NHS1 |
| 0.04% | CMPS | COMPASS PATHWAYS PLC | -- | $32,190.97 | 4,219 | BMC3HS7 |
| 0.04% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $31,900.12 | 13,517 | B4N8MH9 |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $31,804.56 | 813 | BQD3J33 |
| 0.03% | CGEM | CULLINAN THERAPEUTICS INC | -- | $28,751.15 | 2,645 | BM90J52 |
| 0.03% | REPL | REPLIMUNE GROUP INC | -- | $27,077.52 | 3,512 | BDDVW37 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $26,849.80 | 3,604 | BFYQFJ2 |
| 0.03% | KROS | KEROS THERAPEUTICS INC | -- | $26,638.92 | 1,364 | BM7V485 |
| 0.03% | GOSS | GOSSAMER BIO INC | -- | $26,425.65 | 10,363 | BJ0CK86 |
| 0.03% | LENZ | LENZ THERAPEUTICS INC | -- | $26,044.59 | 1,401 | BQV0J03 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $25,586.36 | 6,494 | BMCWKZ2 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $25,228.96 | 3,268 | BQ6C357 |
| 0.03% | FULC | FULCRUM THERAPEUTICS INC | -- | $25,102.28 | 2,423 | BJDX8Z9 |
| 0.03% | CRMD | CORMEDIX INC | -- | $25,013.52 | 3,528 | BJ0LT31 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $24,990.00 | 2,550 | BMFK3H6 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $23,117.57 | 2,521 | BLFBZ32 |
| 0.03% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $22,806.08 | 3,344 | BYP80F1 |
| 0.03% | ABSI | ABSCI CORP | -- | $22,555.55 | 6,733 | BN94K69 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $22,416.84 | 2,559 | BKLXFX5 |
| 0.03% | LYEL | LYELL IMMUNOPHARMA INC | -- | $22,287.00 | 950 | BTNMG41 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $22,181.20 | 2,411 | B91XRN2 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $22,109.76 | 648 | B292NQ7 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $21,544.32 | 3,206 | 2107437 |
| 0.02% | KMDA | KAMADA LTD | -- | $20,560.68 | 2,583 | B2Q9833 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $20,374.20 | 2,646 | B12W3P6 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $20,265.28 | 3,488 | BQHN6C7 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $19,528.96 | 4,672 | BFY7DC4 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $19,280.00 | 4,000 | BYTYP72 |
| 0.02% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $19,229.76 | 5,463 | BYVQJ96 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $19,186.20 | 4,845 | BDFKQ07 |
| 0.02% | ETON | ETON PHARMACEUTICALS INC | -- | $18,819.67 | 1,201 | BGL0JK3 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $18,102.38 | 1,711 | BP81RK8 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $17,999.40 | 1,965 | BSMLR16 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $17,881.28 | 1,292 | B9L5200 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $17,105.40 | 10,062 | BFZNYB7 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $16,500.32 | 4,496 | BZC0D70 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $16,483.46 | 838 | BPBPCG8 |
| 0.02% | NBP | NOVABRIDGE BIOSCIENCES | -- | $16,432.15 | 4,655 | BKRRKY7 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $16,084.15 | 7,481 | BN4JN37 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $15,976.92 | 2,532 | BMF7DT9 |
| 0.02% | PEPG | PEPGEN INC | -- | $15,856.85 | 3,079 | BMTX3D7 |
| 0.02% | CADL | CANDEL THERAPEUTICS INC | -- | $15,264.18 | 2,458 | BP0TQC5 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $14,954.18 | 2,843 | BP81R42 |
| 0.02% | AARD | AARDVARK THERAPEUTICS INC | -- | $14,605.50 | 975 | BTXQTX3 |
| 0.02% | EOLS | EVOLUS INC | -- | $14,568.04 | 2,902 | BDRJH21 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $14,483.52 | 2,256 | B7F2TY6 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $13,716.64 | 2,072 | BKDQKM6 |
| 0.02% | ACRS | ACLARIS THERAPEUTICS INC | -- | $13,291.74 | 4,851 | BYV2W40 |
| 0.01% | LFCR | LIFECORE BIOMEDICAL INC | -- | $13,222.64 | 1,678 | 2517058 |
| 0.01% | LRMR | LARIMAR THERAPEUTICS INC | -- | $13,067.12 | 3,832 | BMXNGZ6 |
| 0.01% | NGNE | NEUROGENE INC | -- | $13,028.40 | 693 | BS2F741 |
| 0.01% | IMRX | IMMUNEERING CORP - CLASS A | -- | $12,807.13 | 2,891 | BMVBZF5 |
| 0.01% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $12,753.02 | 8,981 | BFMLGR4 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $12,382.92 | 3,498 | BLN9Z50 |
| 0.01% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $12,338.74 | 2,102 | BL5B6Z1 |
| 0.01% | OABI | OMNIAB INC | -- | $12,309.95 | 6,445 | BN13S71 |
| 0.01% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $12,159.84 | 1,034 | BPRBTY7 |
| 0.01% | MENS | JYONG BIOTECH LTD | -- | $11,675.72 | 3,404 | BPTK6Z2 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $11,274.88 | 2,528 | BPRB2N7 |
| 0.01% | VOR | VOR BIOPHARMA INC | -- | $11,136.58 | 754 | BRJJYT3 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $11,118.85 | 8,755 | BNR5QT9 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $10,911.46 | 2,642 | BY7RB53 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $10,112.20 | 4,340 | BKX9NQ0 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $9,832.56 | 1,272 | BKC9SX3 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $9,703.62 | 4,371 | BZ8FPH3 |
| 0.01% | HUMA | HUMACYTE INC | -- | $9,558.90 | 8,385 | BMYTJP4 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $9,272.52 | 2,396 | BP7L561 |
| 0.01% | CABA | CABALETTA BIO INC | -- | $9,266.50 | 4,310 | BK5MWR1 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $8,841.56 | 1,388 | BP2NYN2 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $8,659.20 | 5,412 | BRK0149 |
| 0.01% | CDXS | CODEXIS INC | -- | $7,200.10 | 4,045 | B5LL2C2 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $7,117.29 | 2,551 | BKTV702 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $6,736.24 | 4,184 | BNYJR68 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $6,113.80 | 4,367 | BNNXX18 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $5,646.42 | 7,455 | BNNXX52 |
| 0.01% | PYXS | PYXIS ONCOLOGY INC | -- | $5,548.12 | 2,788 | BLBR8D5 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $12.66 | 01 | BTFHQP5 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| 38.38% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 33,852,304 | -- | 5,795 | -- |
| 32.30% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 28,495,520 | -- | 4,878 | -- |
| 23.69% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 20,895,546 | -- | 3,577 | -- |
| 16.45% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,510,634 | -- | 2,484 | -- |
| 15.23% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 13,429,930 | -- | 2,299 | -- |
| 4.19% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,697,758 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $27,111,340.07 | 27,111,340 | -- |
Index
as of 12/31/2025
- Total Number of Companies262
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$7.32 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
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