BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 10/31/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 20.05% | 41.93% | 51.59% | 42.58% | 20.67% | 9.55% | 2.60% | 0.91% | 15.79% | 04/07/2010 |
| BIB Market Price | 20.06% | 42.12% | 51.73% | 42.51% | 20.92% | 9.51% | 2.55% | 0.91% | 15.79% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 11/14/2025- NAV $75.39
- NAV Change $+0.91
- Market Price $75.48
- Market Price Change $+1.01
- Trading Volume (M) 17,513
- 30-Day Median Bid Ask Spread 0.29%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 11/14/2025- NAV $75.39
- NAV Change $+0.91
- Market Price $75.48
- Market Price Change $+1.01
- Trading Volume (M) 17,513
- 30-Day Median Bid Ask Spread 0.29%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 11/14/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.23% | AMGN | AMGEN INC | -- | $4,019,328.64 | 11,936 | 2023607 |
| 4.99% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $3,839,925.60 | 8,784 | 2931034 |
| 4.94% | GILD | GILEAD SCIENCES INC | -- | $3,800,983.06 | 30,403 | 2369174 |
| 3.87% | REGN | REGENERON PHARMACEUTICALS | -- | $2,973,728.00 | 4,288 | 2730190 |
| 3.15% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,423,667.36 | 5,396 | B00FWN1 |
| 2.49% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $1,915,026.30 | 21,493 | 2989044 |
| 2.20% | INSM | INSMED INC | -- | $1,695,312.28 | 8,774 | 2614487 |
| 1.50% | ARGX | ARGENX SE - ADR | -- | $1,152,226.62 | 1,269 | BDVLM39 |
| 1.33% | BIIB | BIOGEN INC | -- | $1,019,709.30 | 6,086 | 2455965 |
| 1.14% | UTHR | UNITED THERAPEUTICS CORP | -- | $875,432.80 | 1,877 | 2430412 |
| 1.10% | INCY | INCYTE CORP | -- | $844,135.75 | 8,105 | 2471950 |
| 1.00% | ILMN | ILLUMINA INC | -- | $769,753.93 | 6,379 | 2613990 |
| 0.91% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $702,608.72 | 17,942 | BMVP7Y0 |
| 0.90% | MEDP | MEDPACE HOLDINGS INC | -- | $688,635.03 | 1,167 | BDCBC61 |
| 0.78% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $596,098.90 | 4,115 | 2623911 |
| 0.76% | SNY | SANOFI-ADR | -- | $580,683.18 | 11,137 | 2964557 |
| 0.75% | ROIV | ROIVANT SCIENCES LTD | -- | $575,059.18 | 28,342 | BMW4NZ9 |
| 0.72% | SMMT | SUMMIT THERAPEUTICS INC | -- | $555,882.93 | 30,831 | BMTVQS7 |
| 0.68% | BBIO | BRIDGEBIO PHARMA INC | -- | $526,605.48 | 7,932 | BK1KWG8 |
| 0.68% | RVMD | REVOLUTION MEDICINES INC | -- | $525,604.50 | 7,758 | BL71K91 |
| 0.67% | VTRS | VIATRIS INC | -- | $518,697.92 | 48,386 | BMWS3X9 |
| 0.67% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $515,905.60 | 2,524 | BV9G6B8 |
| 0.66% | ONC | BEONE MEDICINES LTD-ADR | -- | $510,318.90 | 1,395 | BYYWPW6 |
| 0.64% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $488,990.04 | 924 | BD59BS7 |
| 0.64% | GH | GUARDANT HEALTH INC | -- | $488,553.49 | 5,177 | BFXC911 |
| 0.62% | TEM | TEMPUS AI INC | -- | $479,428.48 | 7,001 | BSLSJJ0 |
| 0.62% | IONS | IONIS PHARMACEUTICALS INC | -- | $473,160.15 | 6,613 | BDJ0LS6 |
| 0.61% | EXEL | EXELIXIS INC | -- | $465,313.80 | 11,172 | 2576941 |
| 0.57% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $436,143.37 | 7,969 | 2437071 |
| 0.56% | BNTX | BIONTECH SE-ADR | -- | $430,297.66 | 4,174 | BK6H543 |
| 0.52% | MRNA | MODERNA INC | -- | $399,985.96 | 16,148 | BGSXTS3 |
| 0.49% | RNA | AVIDITY BIOSCIENCES INC | -- | $378,001.20 | 5,339 | BMWHPY1 |
| 0.46% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $354,932.12 | 2,516 | B4Q5ZN4 |
| 0.44% | HALO | HALOZYME THERAPEUTICS INC | -- | $339,925.62 | 4,854 | 2975098 |
| 0.43% | CYTK | CYTOKINETICS INC | -- | $330,007.48 | 4,967 | BBBSBJ5 |
| 0.39% | MRUS | MERUS NV | -- | $301,091.10 | 3,138 | BZBY005 |
| 0.38% | AXSM | AXSOME THERAPEUTICS INC | -- | $289,437.68 | 2,072 | BYZR4X4 |
| 0.36% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $274,172.78 | 2,758 | BF2YWG4 |
| 0.35% | NUVL | NUVALENT INC-A | -- | $267,015.50 | 2,767 | BMVBZD3 |
| 0.34% | PCVX | VAXCYTE INC | -- | $262,341.72 | 5,388 | BKPVGH6 |
| 0.32% | PTCT | PTC THERAPEUTICS INC | -- | $248,414.70 | 3,299 | B17VCN9 |
| 0.32% | KRYS | KRYSTAL BIOTECH INC | -- | $247,392.00 | 1,200 | BD6JX35 |
| 0.31% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $236,791.14 | 5,739 | BYQBFJ8 |
| 0.28% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $218,378.41 | 2,581 | BDCBCD8 |
| 0.27% | ACLX | ARCELLX INC | -- | $207,043.98 | 2,301 | BPCJ1Q2 |
| 0.26% | ALKS | ALKERMES PLC | -- | $198,982.08 | 6,852 | B3P6D26 |
| 0.26% | CRSP | CRISPR THERAPEUTICS AG | -- | $198,195.69 | 3,773 | BDHF4K6 |
| 0.25% | COGT | COGENT BIOSCIENCES INC | -- | $194,498.46 | 5,799 | BLR6XK8 |
| 0.25% | KYMR | KYMERA THERAPEUTICS INC | -- | $192,741.92 | 2,968 | BMPRZV5 |
| 0.23% | AKRO | AKERO THERAPEUTICS INC | -- | $180,110.00 | 3,320 | BK7Y2V9 |
| 0.23% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $179,209.55 | 4,673 | BP8JSP4 |
| 0.22% | IMVT | IMMUNOVANT INC | -- | $171,711.42 | 7,233 | BJRFSB7 |
| 0.22% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $168,188.04 | 7,002 | 2713317 |
| 0.22% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $166,711.69 | 3,907 | BDD19F8 |
| 0.21% | LGND | LIGAND PHARMACEUTICALS | -- | $163,500.04 | 814 | 2501578 |
| 0.21% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $163,117.50 | 875 | BQ721R4 |
| 0.21% | INDV | INDIVIOR PLC | -- | $157,907.71 | 5,179 | BP0BQQ5 |
| 0.20% | ADMA | ADMA BIOLOGICS INC | -- | $154,106.24 | 9,904 | B9NSBM2 |
| 0.20% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $151,727.40 | 13,035 | BFNF1D6 |
| 0.19% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $149,303.31 | 3,991 | BFZQ0L8 |
| 0.19% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $148,952.40 | 2,085 | BJDX8Y8 |
| 0.17% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $132,353.08 | 4,001 | BJ62Z18 |
| 0.17% | XENE | XENON PHARMACEUTICALS INC | -- | $130,391.24 | 3,199 | BRJ3GY4 |
| 0.17% | IRON | DISC MEDICINE INC | -- | $129,887.80 | 1,444 | BMGJZJ8 |
| 0.17% | CGON | CG ONCOLOGY INC | -- | $129,837.66 | 3,166 | BRBCSP4 |
| 0.17% | VCYT | VERACYTE INC | -- | $128,477.75 | 3,265 | BFTWZY0 |
| 0.17% | TARS | TARSUS PHARMACEUTICALS INC | -- | $127,682.92 | 1,751 | BMH5RL1 |
| 0.17% | TVTX | TRAVERE THERAPEUTICS INC | -- | $127,581.00 | 3,698 | BLFGJD5 |
| 0.16% | APGE | APOGEE THERAPEUTICS INC | -- | $125,432.50 | 1,915 | BM9HHL5 |
| 0.16% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $124,425.00 | 4,977 | BKX9VD3 |
| 0.16% | FOLD | AMICUS THERAPEUTICS INC | -- | $121,287.12 | 12,794 | B19FQ48 |
| 0.16% | GRAL | GRAIL INC | -- | $119,285.74 | 1,498 | BSLSSX7 |
| 0.15% | IDYA | IDEAYA BIOSCIENCES INC | -- | $116,861.04 | 3,636 | BK0VHF6 |
| 0.15% | MLYS | MINERALYS THERAPEUTICS INC | -- | $112,460.05 | 2,753 | BP9N0G0 |
| 0.14% | DYN | DYNE THERAPEUTICS INC | -- | $110,936.16 | 5,904 | BN15WD1 |
| 0.14% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $109,887.80 | 3,980 | BLB0YQ9 |
| 0.14% | APLS | APELLIS PHARMACEUTICALS INC | -- | $106,590.19 | 5,243 | BYTQ6X1 |
| 0.14% | DNLI | DENALI THERAPEUTICS INC | -- | $105,860.80 | 6,070 | BD2B4V0 |
| 0.14% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $105,802.97 | 3,493 | BMX9K07 |
| 0.14% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $105,283.80 | 2,412 | BCBVTX1 |
| 0.14% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $104,805.00 | 2,329 | B72ZBG4 |
| 0.13% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $99,463.00 | 4,372 | BKY5JZ8 |
| 0.12% | AVDL | AVADEL PHARMACEUTICALS | -- | $94,923.24 | 4,029 | BDGMC59 |
| 0.12% | BEAM | BEAM THERAPEUTICS INC | -- | $91,224.00 | 4,200 | BK6L288 |
| 0.12% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $91,092.68 | 2,474 | BQS9486 |
| 0.12% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $89,097.90 | 6,319 | BJ5FZ74 |
| 0.11% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $83,872.40 | 5,464 | BFWLC09 |
| 0.11% | VCEL | VERICEL CORP | -- | $83,426.98 | 2,093 | BSBMN89 |
| 0.11% | TERN | TERNS PHARMACEUTICALS INC | -- | $81,892.80 | 3,630 | BMDJ0C9 |
| 0.11% | IBRX | IMMUNITYBIO INC | -- | $81,600.48 | 39,231 | BNSP0B8 |
| 0.11% | OCUL | OCULAR THERAPEUTIX INC | -- | $81,597.30 | 7,221 | BNZB1X8 |
| 0.11% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $81,195.58 | 2,386 | BKSGZN7 |
| 0.10% | SRPT | SAREPTA THERAPEUTICS INC | -- | $76,312.17 | 4,057 | B8DPDT7 |
| 0.10% | ANIP | ANI PHARMACEUTICALS INC | -- | $75,618.00 | 900 | BCDWBX6 |
| 0.10% | TXG | 10X GENOMICS INC-CLASS A | -- | $75,477.50 | 4,750 | BKS3RS7 |
| 0.10% | VERA | VERA THERAPEUTICS INC | -- | $75,070.80 | 2,648 | BL55460 |
| 0.10% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $73,422.90 | 17,735 | BM9FJ13 |
| 0.09% | JANX | JANUX THERAPEUTICS INC | -- | $73,024.32 | 2,494 | BMFX8Y7 |
| 0.09% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $72,737.28 | 1,804 | BRXB0C0 |
| 0.09% | ALVO | ALVOTECH SA | -- | $71,309.61 | 12,989 | BPNTJ34 |
| 0.09% | QURE | UNIQURE NV | -- | $68,216.04 | 2,283 | BJFSR88 |
| 0.09% | TWST | TWIST BIOSCIENCE CORP | -- | $67,309.35 | 2,505 | BGKG6G7 |
| 0.08% | MNKD | MANNKIND CORP | -- | $64,439.10 | 12,735 | BF081J4 |
| 0.08% | HROW | HARROW INC | -- | $62,612.65 | 1,535 | BHNDW86 |
| 0.08% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $61,688.04 | 8,713 | 2100362 |
| 0.08% | STOK | STOKE THERAPEUTICS INC | -- | $60,310.25 | 2,275 | BJQ05Z6 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $60,141.84 | 1,308 | BX7RSN3 |
| 0.08% | PGEN | PRECIGEN INC | -- | $59,970.25 | 12,365 | BKM5C84 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $59,748.90 | 1,662 | BLCD809 |
| 0.08% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $59,449.74 | 3,577 | BN7Q7R7 |
| 0.08% | SYRE | SPYRE THERAPEUTICS INC | -- | $58,891.00 | 2,506 | BQBBDY8 |
| 0.08% | ARDX | ARDELYX INC | -- | $58,600.00 | 10,000 | BN89V40 |
| 0.08% | INVA | INNOVIVA INC | -- | $58,228.25 | 2,617 | BDDXF67 |
| 0.08% | ZYME | ZYMEWORKS INC | -- | $57,782.40 | 3,120 | BPCQZY9 |
| 0.07% | TRVI | TREVI THERAPEUTICS INC | -- | $57,463.98 | 5,054 | BJH9ZN0 |
| 0.07% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $54,225.99 | 2,457 | BMFD115 |
| 0.07% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $53,817.96 | 4,866 | BRJZSK0 |
| 0.07% | GMAB | GENMAB A/S -SP ADR | -- | $52,652.40 | 1,740 | BBC9WC7 |
| 0.07% | NVCR | NOVOCURE LTD | -- | $52,524.80 | 4,640 | BYSS4X4 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $50,269.74 | 1,929 | BNFWZS4 |
| 0.06% | ORIC | ORIC PHARMACEUTICALS INC | -- | $49,367.50 | 4,030 | BKVDFF7 |
| 0.06% | CVAC | CUREVAC NV | -- | $49,341.60 | 9,345 | BN4RD42 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $48,127.54 | 6,703 | BLR7H87 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $47,636.26 | 602 | BNSP8K3 |
| 0.06% | NVAX | NOVAVAX INC | -- | $46,977.80 | 6,740 | BJDQXG4 |
| 0.06% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $46,940.31 | 3,699 | BPCK358 |
| 0.06% | WVE | WAVE LIFE SCIENCES LTD | -- | $46,756.32 | 6,604 | BYZG9R0 |
| 0.06% | TSHA | TAYSHA GENE THERAPIES INC | -- | $46,751.60 | 11,320 | BNC1BX1 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $45,767.07 | 12,403 | BL53SR3 |
| 0.06% | URGN | UROGEN PHARMA LTD | -- | $45,642.96 | 1,921 | BZ7PJQ1 |
| 0.06% | RLAY | RELAY THERAPEUTICS INC | -- | $45,004.95 | 7,155 | BN2R582 |
| 0.06% | PCRX | PACIRA BIOSCIENCES INC | -- | $44,349.70 | 1,865 | B3X26D8 |
| 0.06% | XNCR | XENCOR INC | -- | $44,207.73 | 2,961 | BGCYWN8 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $44,098.73 | 5,063 | B8K7T65 |
| 0.06% | ZLAB | ZAI LAB LTD-ADR | -- | $43,195.50 | 1,986 | BD9GVY0 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $42,840.63 | 10,737 | BMFJJ97 |
| 0.06% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $42,835.52 | 2,942 | BJLKVS6 |
| 0.05% | ORKA | ORUKA THERAPEUTICS INC | -- | $42,028.16 | 1,552 | BKVF0J2 |
| 0.05% | NRIX | NURIX THERAPEUTICS INC | -- | $40,627.20 | 3,174 | BMVLGP2 |
| 0.05% | KURA | KURA ONCOLOGY INC | -- | $40,360.41 | 3,602 | BYZD465 |
| 0.05% | CSTL | CASTLE BIOSCIENCES INC | -- | $40,206.90 | 1,202 | BKLCWZ3 |
| 0.05% | ANAB | ANAPTYSBIO INC | -- | $39,332.66 | 1,163 | BDRW1L7 |
| 0.05% | FTRE | FORTREA HOLDINGS INC | -- | $39,214.47 | 3,767 | BRXYZ57 |
| 0.05% | NTLA | INTELLIA THERAPEUTICS INC | -- | $38,749.80 | 4,454 | BYZM6C2 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $38,109.50 | 845 | BL95N25 |
| 0.05% | TNGX | TANGO THERAPEUTICS INC | -- | $37,737.23 | 4,619 | BP2P6L0 |
| 0.05% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $37,400.00 | 4,250 | BLB0YH0 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $37,096.93 | 15,019 | BF0DMK7 |
| 0.05% | RAPP | RAPPORT THERAPEUTICS INC | -- | $36,920.55 | 1,515 | BR3T9B6 |
| 0.05% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $36,804.68 | 2,563 | BP7KZP7 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $36,345.10 | 2,090 | BMNDK09 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $35,965.64 | 7,957 | BZ0QMB7 |
| 0.05% | MNMD | MIND MEDICINE MINDMED INC | -- | $35,866.00 | 3,160 | BPQYY97 |
| 0.05% | TYRA | TYRA BIOSCIENCES INC | -- | $34,841.95 | 2,215 | BMVNDH9 |
| 0.05% | CRMD | CORMEDIX INC | -- | $34,832.76 | 3,099 | BJ0LT31 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $34,821.27 | 1,683 | BMGTLY5 |
| 0.04% | SPRY | ARS PHARMACEUTICALS INC | -- | $33,669.21 | 4,101 | BMCR7V2 |
| 0.04% | EYPT | EYEPOINT PHARMACEUTICALS INC | -- | $33,141.96 | 2,862 | BMGS7L1 |
| 0.04% | VIR | VIR BIOTECHNOLOGY INC | -- | $32,456.95 | 5,765 | BK4PZ38 |
| 0.04% | ARVN | ARVINAS INC | -- | $32,206.79 | 3,047 | BDZ30Q0 |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $31,245.30 | 745 | BQD3J33 |
| 0.04% | SVRA | SAVARA INC | -- | $30,852.50 | 7,175 | BYXGN81 |
| 0.04% | ERAS | ERASCA INC | -- | $30,376.92 | 11,774 | BNLYBF3 |
| 0.04% | LENZ | LENZ THERAPEUTICS INC | -- | $30,284.80 | 1,183 | BQV0J03 |
| 0.04% | GERN | GERON CORP | -- | $29,656.48 | 26,479 | 2370381 |
| 0.04% | ATXS | ASTRIA THERAPEUTICS INC | -- | $29,451.51 | 2,343 | BMYRFN8 |
| 0.04% | REPL | REPLIMUNE GROUP INC | -- | $29,136.59 | 3,241 | BDDVW37 |
| 0.04% | KROS | KEROS THERAPEUTICS INC | -- | $29,065.84 | 1,684 | BM7V485 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $28,919.66 | 1,958 | BQS7491 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $28,452.18 | 2,089 | BD06CS0 |
| 0.04% | PSNL | PERSONALIS INC | -- | $27,636.80 | 3,680 | BJQ0608 |
| 0.04% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $27,338.22 | 3,338 | BFYQFJ2 |
| 0.04% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $27,134.38 | 3,094 | BYP80F1 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $27,052.41 | 5,019 | BYVQJ96 |
| 0.03% | PRME | PRIME MEDICINE INC | -- | $24,459.46 | 7,258 | BPBJFM7 |
| 0.03% | ESPR | ESPERION THERAPEUTICS INC | -- | $24,270.10 | 8,369 | BBNBTD2 |
| 0.03% | RGNX | REGENXBIO INC | -- | $24,113.45 | 2,095 | BZ0G875 |
| 0.03% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $23,923.20 | 2,848 | BMZ4LN0 |
| 0.03% | LXRX | LEXICON PHARMACEUTICALS INC | -- | $22,475.16 | 15,084 | BWFZX59 |
| 0.03% | OMER | OMEROS CORP | -- | $22,232.75 | 2,825 | B4NB858 |
| 0.03% | ALMS | ALUMIS INC | -- | $22,195.92 | 4,021 | BPLQG36 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $22,173.69 | 2,233 | B91XRN2 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $21,861.84 | 6,006 | BMCWKZ2 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $21,163.60 | 6,740 | B3MZ6K5 |
| 0.03% | CGEM | CULLINAN THERAPEUTICS INC | -- | $20,947.50 | 2,450 | BM90J52 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $20,911.02 | 1,938 | BKLXFX5 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $20,699.28 | 2,331 | BLFBZ32 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $20,249.60 | 2,240 | BQ6C357 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $20,071.87 | 12,467 | B4N8MH9 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $19,815.44 | 3,807 | BMC3HS7 |
| 0.03% | HCM | HUTCHMED CHINA-ADR | -- | $19,438.12 | 1,289 | BYXV9H7 |
| 0.03% | EOLS | EVOLUS INC | -- | $19,392.92 | 2,686 | BDRJH21 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $18,648.84 | 596 | B292NQ7 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $17,832.00 | 2,972 | 2107437 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $17,810.65 | 6,721 | BN4JN37 |
| 0.02% | ABSI | ABSCI CORP | -- | $17,503.74 | 6,207 | BN94K69 |
| 0.02% | DSGN | DESIGN THERAPEUTICS INC | -- | $17,415.31 | 2,363 | BMFK3H6 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $15,278.88 | 3,664 | BFY7DC4 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $14,387.04 | 776 | BPBPCG8 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $14,250.81 | 2,577 | BP81R42 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $13,825.00 | 1,580 | BP81RK8 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $13,709.43 | 4,167 | BZC0D70 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $13,707.92 | 3,233 | BQHN6C7 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $13,664.00 | 4,480 | BDFKQ07 |
| 0.02% | AMRN | AMARIN CORP PLC -ADR | -- | $13,660.24 | 836 | BN72KB0 |
| 0.02% | LYEL | LYELL IMMUNOPHARMA INC | -- | $13,527.07 | 799 | BTNMG41 |
| 0.02% | NGNE | NEUROGENE INC | -- | $13,525.38 | 594 | BS2F741 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $13,311.67 | 1,949 | BL5B6Z1 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $12,987.14 | 3,563 | BYTYP72 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $12,441.60 | 1,920 | BKDQKM6 |
| 0.02% | ANNX | ANNEXON INC | -- | $12,360.31 | 4,561 | BMVV9R5 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $12,349.60 | 1,795 | BSMLR16 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $12,002.38 | 3,551 | BMXNGZ6 |
| 0.01% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $11,403.88 | 8,324 | BFMLGR4 |
| 0.01% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $11,327.07 | 9,209 | BFZNYB7 |
| 0.01% | PYXS | PYXIS ONCOLOGY INC | -- | $11,218.28 | 2,573 | BLBR8D5 |
| 0.01% | FHTX | FOGHORN THERAPEUTICS INC | -- | $11,007.43 | 2,347 | BMF7DT9 |
| 0.01% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $10,709.28 | 888 | B9L5200 |
| 0.01% | VNDA | VANDA PHARMACEUTICALS INC | -- | $10,661.85 | 2,451 | B12W3P6 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $9,883.45 | 2,221 | BP7L561 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $9,753.20 | 3,295 | BLN9Z50 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $9,705.80 | 3,733 | BZ8FPH3 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $9,042.93 | 2,301 | BY7RB53 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $8,186.02 | 1,126 | BKC9SX3 |
| 0.01% | HUMA | HUMACYTE INC | -- | $8,086.02 | 6,574 | BMYTJP4 |
| 0.01% | RNAC | CARTESIAN THERAPEUTICS INC | -- | $8,064.26 | 1,081 | BQB9HM8 |
| 0.01% | OABI | OMNIAB INC | -- | $7,941.96 | 5,091 | BN13S71 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $7,298.85 | 2,955 | BKX9NQ0 |
| 0.01% | MXCT | MAXCYTE INC | -- | $6,991.50 | 4,425 | BKMQF66 |
| 0.01% | PEPG | PEPGEN INC | -- | $6,460.62 | 1,363 | BMTX3D7 |
| 0.01% | CDXS | CODEXIS INC | -- | $6,162.17 | 3,746 | B5LL2C2 |
| 0.01% | MRSN | MERSANA THERAPEUTICS INC | -- | $5,779.44 | 207 | BVPKH99 |
| 0.01% | NKTX | NKARTA INC | -- | $5,516.50 | 2,950 | BK80YJ8 |
| 0.01% | CLYM | CLIMB BIO INC | -- | $5,346.60 | 2,814 | BMW5LX6 |
| 0.01% | ALEC | ALECTOR INC | -- | $5,210.48 | 4,202 | BJ4LDC4 |
| 0.01% | FATE | FATE THERAPEUTICS INC | -- | $4,613.70 | 4,786 | BCZS820 |
| 0.01% | PLRX | PLIANT THERAPEUTICS INC | -- | $4,282.32 | 2,549 | BMDWW66 |
| 0.01% | MGNX | MACROGENICS INC | -- | $3,936.00 | 2,624 | BFDV8K0 |
| -- | TVGN | TEVOGEN BIO HOLDINGS INC | -- | $3,405.62 | 8,165 | BPG5P75 |
| -- | ARTV | ARTIVA BIOTHERAPEUTICS INC | -- | $3,298.75 | 1,015 | BMF1LJ7 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $3,183.99 | 3,519 | BF12XC2 |
| -- | BMEA | BIOMEA FUSION INC | -- | $3,162.88 | 2,471 | BNKF6N0 |
| -- | ACRV | ACRIVON THERAPEUTICS INC | -- | $2,925.44 | 1,306 | BP2TPK4 |
| -- | TCRX | TSCAN THERAPEUTICS INC | -- | $2,393.60 | 2,176 | BNLYBJ7 |
| -- | OKUR | ONKURE THERAPEUTICS INC-A | -- | $1,671.42 | 534 | BT7KGT6 |
| -- | APLT | APPLIED THERAPEUTICS INC | -- | $1,301.07 | 5,960 | BJL38Z1 |
| -- | QTTB | Q32 BIO INC | -- | $1,090.80 | 505 | BS2FKQ4 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 35.22% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 27,080,848 | -- | 4,905 | -- |
| 35.17% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 27,047,722 | -- | 4,899 | -- |
| 22.08% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 16,977,290 | -- | 3,075 | -- |
| 17.83% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 13,714,338 | -- | 2,484 | -- |
| 16.51% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 12,692,940 | -- | 2,299 | -- |
| 8.29% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 6,376,836 | -- | 1,155 | -- |
| -- | -- | TREASURY BILL | -- | $4,998,409.15 | 5,000,000 | BMGHP58 |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $21,860,398.12 | 21,860,398 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
Read More