BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 12/31/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 1/22/2026- NAV $88.21
- NAV Change $+2.75
- Market Price $88.17
- Market Price Change $+2.74
- Trading Volume (M) 16,391
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 1/22/2026- NAV $88.21
- NAV Change $+2.75
- Market Price $88.17
- Market Price Change $+2.74
- Trading Volume (M) 16,391
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 12/31/2025
Holdings
as of 1/21/2026
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.96% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,400,871.68 | 11,712 | 2931034 |
| 5.75% | GILD | GILEAD SCIENCES INC | -- | $5,210,363.16 | 40,356 | 2369174 |
| 5.58% | AMGN | AMGEN INC | -- | $5,050,920.00 | 14,700 | 2023607 |
| 3.99% | REGN | REGENERON PHARMACEUTICALS | -- | $3,614,018.59 | 4,823 | 2730190 |
| 2.49% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,256,715.50 | 6,175 | B00FWN1 |
| 1.72% | INSM | INSMED INC | -- | $1,556,947.20 | 9,960 | 2614487 |
| 1.31% | BIIB | BIOGEN INC | -- | $1,182,619.62 | 6,851 | 2455965 |
| 1.22% | ARGX | ARGENX SE - ADR | -- | $1,109,446.83 | 1,359 | BDVLM39 |
| 1.20% | ILMN | ILLUMINA INC | -- | $1,088,097.28 | 7,136 | 2613990 |
| 1.17% | RVMD | REVOLUTION MEDICINES INC | -- | $1,061,060.84 | 9,028 | BL71K91 |
| 1.06% | INCY | INCYTE CORP | -- | $959,614.56 | 9,168 | 2471950 |
| 1.04% | UTHR | UNITED THERAPEUTICS CORP | -- | $944,707.47 | 2,011 | 2430412 |
| 1.00% | MRNA | MODERNA INC | -- | $908,733.64 | 18,244 | BGSXTS3 |
| 0.90% | MEDP | MEDPACE HOLDINGS INC | -- | $817,317.03 | 1,317 | BDCBC61 |
| 0.87% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $792,374.28 | 19,949 | BMVP7Y0 |
| 0.82% | ROIV | ROIVANT SCIENCES LTD | -- | $746,528.28 | 32,486 | BMW4NZ9 |
| 0.78% | BBIO | BRIDGEBIO PHARMA INC | -- | $703,271.85 | 8,999 | BK1KWG8 |
| 0.77% | VTRS | VIATRIS INC | -- | $701,907.30 | 53,786 | BMWS3X9 |
| 0.77% | GH | GUARDANT HEALTH INC | -- | $699,361.50 | 6,042 | BFXC911 |
| 0.70% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $630,468.96 | 4,656 | 2623911 |
| 0.69% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $621,164.22 | 2,867 | BV9G6B8 |
| 0.66% | IONS | IONIS PHARMACEUTICALS INC | -- | $600,884.16 | 7,564 | BDJ0LS6 |
| 0.65% | SMMT | SUMMIT THERAPEUTICS INC | -- | $585,790.25 | 34,765 | BMTVQS7 |
| 0.63% | SNY | SANOFI-ADR | -- | $570,692.44 | 12,358 | 2964557 |
| 0.62% | EXEL | EXELIXIS INC | -- | $561,155.63 | 12,523 | 2576941 |
| 0.61% | BNTX | BIONTECH SE-ADR | -- | $557,078.00 | 4,721 | BK6H543 |
| 0.58% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $527,782.14 | 1,062 | BD59BS7 |
| 0.58% | TEM | TEMPUS AI INC | -- | $527,328.36 | 8,073 | BSLSJJ0 |
| 0.56% | RNA | AVIDITY BIOSCIENCES INC | -- | $511,165.40 | 7,036 | BMWHPY1 |
| 0.56% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $509,340.44 | 8,972 | 2437071 |
| 0.55% | ONC | BEONE MEDICINES LTD-ADR | -- | $502,210.80 | 1,470 | BYYWPW6 |
| 0.53% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $480,076.08 | 2,838 | B4Q5ZN4 |
| 0.49% | AXSM | AXSOME THERAPEUTICS INC | -- | $445,141.40 | 2,354 | BYZR4X4 |
| 0.47% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $428,313.60 | 6,336 | BYQBFJ8 |
| 0.43% | HALO | HALOZYME THERAPEUTICS INC | -- | $393,831.32 | 5,492 | 2975098 |
| 0.43% | KRYS | KRYSTAL BIOTECH INC | -- | $387,244.00 | 1,354 | BD6JX35 |
| 0.41% | NUVL | NUVALENT INC-A | -- | $367,900.96 | 3,374 | BMVBZD3 |
| 0.40% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $365,116.80 | 1,168 | BQ721R4 |
| 0.40% | CYTK | CYTOKINETICS INC | -- | $359,958.40 | 5,710 | BBBSBJ5 |
| 0.37% | CAI | CARIS LIFE SCIENCES INC | -- | $335,724.48 | 13,176 | BT18HP9 |
| 0.37% | ABVX | ABIVAX SA-ADR | -- | $330,747.56 | 2,756 | BLC89B2 |
| 0.36% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $330,140.20 | 3,116 | BF2YWG4 |
| 0.35% | IBRX | IMMUNITYBIO INC | -- | $318,299.24 | 45,997 | BNSP0B8 |
| 0.34% | PCVX | VAXCYTE INC | -- | $306,994.86 | 6,113 | BKPVGH6 |
| 0.32% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $292,624.80 | 3,120 | BQS9486 |
| 0.32% | COGT | COGENT BIOSCIENCES INC | -- | $286,122.90 | 7,171 | BLR6XK8 |
| 0.31% | PTCT | PTC THERAPEUTICS INC | -- | $283,274.44 | 3,749 | B17VCN9 |
| 0.29% | ALKS | ALKERMES PLC | -- | $261,017.35 | 7,711 | B3P6D26 |
| 0.27% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $245,632.53 | 4,433 | BDD19F8 |
| 0.27% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $244,874.91 | 2,919 | BDCBCD8 |
| 0.27% | CRSP | CRISPR THERAPEUTICS AG | -- | $243,822.15 | 4,455 | BDHF4K6 |
| 0.26% | KYMR | KYMERA THERAPEUTICS INC | -- | $237,686.40 | 3,360 | BMPRZV5 |
| 0.25% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $223,848.00 | 2,400 | BJDX8Y8 |
| 0.24% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $219,474.30 | 4,766 | BFZQ0L8 |
| 0.24% | CGON | CG ONCOLOGY INC | -- | $215,208.71 | 3,767 | BRBCSP4 |
| 0.24% | IMVT | IMMUNOVANT INC | -- | $213,051.76 | 8,188 | BJRFSB7 |
| 0.23% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $211,430.76 | 7,901 | 2713317 |
| 0.23% | APGE | APOGEE THERAPEUTICS INC | -- | $209,771.51 | 2,561 | BM9HHL5 |
| 0.23% | FOLD | AMICUS THERAPEUTICS INC | -- | $206,754.80 | 14,408 | B19FQ48 |
| 0.22% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $201,262.80 | 14,680 | BFNF1D6 |
| 0.21% | ADMA | ADMA BIOLOGICS INC | -- | $192,939.04 | 11,114 | B9NSBM2 |
| 0.21% | INDV | INDIVIOR PLC | -- | $192,339.36 | 5,832 | BP0BQQ5 |
| 0.21% | ACLX | ARCELLX INC | -- | $185,949.00 | 2,700 | BPCJ1Q2 |
| 0.20% | GRAL | GRAIL INC | -- | $183,947.40 | 1,820 | BSLSSX7 |
| 0.20% | LGND | LIGAND PHARMACEUTICALS | -- | $183,349.69 | 919 | 2501578 |
| 0.20% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $179,712.30 | 5,295 | BP8JSP4 |
| 0.18% | VCYT | VERACYTE INC | -- | $159,863.60 | 3,692 | BFTWZY0 |
| 0.17% | TERN | TERNS PHARMACEUTICALS INC | -- | $154,228.62 | 4,207 | BMDJ0C9 |
| 0.17% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $152,724.00 | 5,720 | BKX9VD3 |
| 0.16% | XENE | XENON PHARMACEUTICALS INC | -- | $148,010.00 | 3,610 | BRJ3GY4 |
| 0.16% | BEAM | BEAM THERAPEUTICS INC | -- | $147,477.68 | 4,739 | BK6L288 |
| 0.16% | IDYA | IDEAYA BIOSCIENCES INC | -- | $147,424.94 | 4,094 | BK0VHF6 |
| 0.16% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $144,562.56 | 4,944 | BKY5JZ8 |
| 0.16% | TARS | TARSUS PHARMACEUTICALS INC | -- | $141,058.94 | 1,982 | BMH5RL1 |
| 0.15% | VERA | VERA THERAPEUTICS INC | -- | $136,623.45 | 2,985 | BL55460 |
| 0.15% | ERAS | ERASCA INC | -- | $133,152.45 | 13,249 | BNLYBF3 |
| 0.15% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $132,614.56 | 2,678 | B72ZBG4 |
| 0.15% | IRON | DISC MEDICINE INC | -- | $132,105.96 | 1,764 | BMGJZJ8 |
| 0.14% | DNLI | DENALI THERAPEUTICS INC | -- | $127,391.40 | 6,849 | BD2B4V0 |
| 0.14% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $125,186.25 | 7,125 | BJ5FZ74 |
| 0.14% | TWST | TWIST BIOSCIENCE CORP | -- | $124,664.40 | 2,856 | BGKG6G7 |
| 0.14% | APLS | APELLIS PHARMACEUTICALS INC | -- | $123,793.55 | 5,909 | BYTQ6X1 |
| 0.14% | TXG | 10X GENOMICS INC-CLASS A | -- | $123,424.56 | 5,442 | BKS3RS7 |
| 0.14% | SYRE | SPYRE THERAPEUTICS INC | -- | $123,145.77 | 3,623 | BQBBDY8 |
| 0.13% | ALMS | ALUMIS INC | -- | $121,127.20 | 4,540 | BPLQG36 |
| 0.13% | TVTX | TRAVERE THERAPEUTICS INC | -- | $118,028.50 | 4,178 | BLFGJD5 |
| 0.13% | DYN | DYNE THERAPEUTICS INC | -- | $116,725.00 | 6,670 | BN15WD1 |
| 0.13% | MLYS | MINERALYS THERAPEUTICS INC | -- | $115,721.76 | 3,696 | BP9N0G0 |
| 0.13% | OCUL | OCULAR THERAPEUTIX INC | -- | $113,674.68 | 9,954 | BNZB1X8 |
| 0.12% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $110,695.32 | 24,012 | BM9FJ13 |
| 0.12% | WVE | WAVE LIFE SCIENCES LTD | -- | $108,829.58 | 7,807 | BYZG9R0 |
| 0.12% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $104,651.15 | 4,505 | BLB0YQ9 |
| 0.12% | SRPT | SAREPTA THERAPEUTICS INC | -- | $104,563.41 | 4,893 | B8DPDT7 |
| 0.11% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $102,488.75 | 4,505 | BJ62Z18 |
| 0.11% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $98,696.10 | 2,690 | BKSGZN7 |
| 0.11% | MAZE | MAZE THERAPEUTICS INC | -- | $98,193.90 | 2,247 | BSRK699 |
| 0.11% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $96,510.59 | 3,671 | BMZ4LN0 |
| 0.10% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $91,177.82 | 6,169 | BFWLC09 |
| 0.10% | ARDX | ARDELYX INC | -- | $90,662.53 | 11,347 | BN89V40 |
| 0.10% | NRIX | NURIX THERAPEUTICS INC | -- | $90,040.68 | 4,734 | BMVLGP2 |
| 0.10% | GMAB | GENMAB A/S -SP ADR | -- | $89,953.50 | 2,730 | BBC9WC7 |
| 0.10% | ANIP | ANI PHARMACEUTICALS INC | -- | $89,710.48 | 1,049 | BCDWBX6 |
| 0.10% | VCEL | VERICEL CORP | -- | $89,094.64 | 2,362 | BSBMN89 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $88,219.47 | 2,109 | BRXB0C0 |
| 0.10% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $86,765.76 | 5,128 | BPCK358 |
| 0.10% | MBX | MBX BIOSCIENCES INC | -- | $86,165.73 | 2,097 | BQXJKH2 |
| 0.09% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $85,989.12 | 5,484 | BRJZSK0 |
| 0.09% | SION | SIONNA THERAPEUTICS INC | -- | $85,006.36 | 2,084 | BQKXDX4 |
| 0.09% | ZYME | ZYMEWORKS INC | -- | $83,705.25 | 3,495 | BPCQZY9 |
| 0.09% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $83,290.68 | 4,059 | BN7Q7R7 |
| 0.09% | PHVS | PHARVARIS NV | -- | $82,282.41 | 2,991 | BMZ2X38 |
| 0.09% | MNKD | MANNKIND CORP | -- | $81,961.34 | 14,354 | BF081J4 |
| 0.09% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $81,628.32 | 3,932 | BMX9K07 |
| 0.09% | HROW | HARROW INC | -- | $81,517.60 | 1,730 | BHNDW86 |
| 0.09% | UPB | UPSTREAM BIO INC | -- | $79,733.16 | 2,524 | BRCFFK6 |
| 0.09% | -- | DEFINIUM THERAPEUTICS INC COMMON STOCK USD 0 | -- | $78,890.00 | 4,600 | -- |
| 0.09% | STOK | STOKE THERAPEUTICS INC | -- | $78,676.50 | 2,667 | BJQ05Z6 |
| 0.09% | TNGX | TANGO THERAPEUTICS INC | -- | $78,675.39 | 6,289 | BP2P6L0 |
| 0.09% | ORKA | ORUKA THERAPEUTICS INC | -- | $77,914.06 | 2,261 | BKVF0J2 |
| 0.09% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $77,259.20 | 3,488 | BYP80F1 |
| 0.08% | NTLA | INTELLIA THERAPEUTICS INC | -- | $75,944.39 | 5,413 | BYZM6C2 |
| 0.08% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $75,385.06 | 2,771 | BMFD115 |
| 0.08% | NVAX | NOVAVAX INC | -- | $75,131.10 | 7,589 | BJDQXG4 |
| 0.08% | RAPT | RAPT THERAPEUTICS INC | -- | $74,547.34 | 1,294 | BTJZB49 |
| 0.08% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $73,983.91 | 2,723 | BCBVTX1 |
| 0.08% | PGEN | PRECIGEN INC | -- | $73,862.06 | 16,561 | BKM5C84 |
| 0.08% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $73,683.43 | 3,041 | BP7KZP7 |
| 0.08% | ALVO | ALVOTECH SA | -- | $73,674.72 | 14,618 | BPNTJ34 |
| 0.08% | FTRE | FORTREA HOLDINGS INC | -- | $73,398.15 | 4,315 | BRXYZ57 |
| 0.08% | TYRA | TYRA BIOSCIENCES INC | -- | $73,339.56 | 2,492 | BMVNDH9 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $71,885.73 | 2,037 | BLCD809 |
| 0.08% | NVCR | NOVOCURE LTD | -- | $70,905.24 | 5,229 | BYSS4X4 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $69,386.76 | 1,476 | BX7RSN3 |
| 0.08% | INVA | INNOVIVA INC | -- | $68,443.20 | 3,492 | BDDXF67 |
| 0.07% | KOD | KODIAK SCIENCES INC | -- | $66,160.67 | 2,477 | BFXC933 |
| 0.07% | ATAI | ATAIBECKLEY INC | -- | $66,147.90 | 16,961 | BWJDYK1 |
| 0.07% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $66,071.04 | 9,832 | 2100362 |
| 0.07% | QURE | UNIQURE NV | -- | $63,241.66 | 2,909 | BJFSR88 |
| 0.07% | TRVI | TREVI THERAPEUTICS INC | -- | $61,676.40 | 5,988 | BJH9ZN0 |
| 0.07% | TSHA | TAYSHA GENE THERAPIES INC | -- | $61,145.76 | 12,792 | BNC1BX1 |
| 0.07% | RLAY | RELAY THERAPEUTICS INC | -- | $61,066.46 | 8,099 | BN2R582 |
| 0.07% | ANAB | ANAPTYSBIO INC | -- | $60,357.24 | 1,293 | BDRW1L7 |
| 0.07% | EYPT | EYEPOINT INC | -- | $60,116.63 | 3,871 | BMGS7L1 |
| 0.07% | ABCL | ABCELLERA BIOLOGICS INC | -- | $59,830.12 | 13,979 | BL53SR3 |
| 0.07% | SANA | SANA BIOTECHNOLOGY INC | -- | $59,209.64 | 12,439 | BMFJJ97 |
| 0.07% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $59,039.76 | 7,748 | BLR7H87 |
| 0.06% | SVRA | SAVARA INC | -- | $58,817.38 | 9,502 | BYXGN81 |
| 0.06% | RAPP | RAPPORT THERAPEUTICS INC | -- | $58,687.20 | 2,223 | BR3T9B6 |
| 0.06% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $57,875.65 | 4,795 | BLB0YH0 |
| 0.06% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $56,268.12 | 2,146 | BNFWZS4 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $55,855.74 | 1,363 | BKLCWZ3 |
| 0.06% | ORIC | ORIC PHARMACEUTICALS INC | -- | $55,713.00 | 4,548 | BKVDFF7 |
| 0.06% | SEPN | SEPTERNA INC | -- | $55,097.85 | 2,091 | BQNKXX2 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $51,386.94 | 5,697 | B8K7T65 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $50,992.90 | 679 | BNSP8K3 |
| 0.05% | ZBIO | ZENAS BIOPHARMA INC | -- | $49,229.67 | 2,513 | BQB42H3 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $48,195.42 | 2,366 | BMNDK09 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $48,191.04 | 4,616 | BMCR7V2 |
| 0.05% | GHRS | GH RESEARCH PLC | -- | $47,423.89 | 2,897 | BP6C0S2 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $46,731.18 | 18,618 | BF0DMK7 |
| 0.05% | ANNX | ANNEXON INC | -- | $46,408.75 | 6,775 | BMVV9R5 |
| 0.05% | VTYX | VENTYX BIOSCIENCES INC | -- | $46,214.84 | 3,332 | BMG99Y1 |
| 0.05% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $45,307.69 | 3,329 | BJLKVS6 |
| 0.05% | VIR | VIR BIOTECHNOLOGY INC | -- | $45,089.18 | 6,497 | BK4PZ38 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $44,112.64 | 1,928 | BMGTLY5 |
| 0.05% | BCAX | BICARA THERAPEUTICS INC | -- | $43,443.20 | 2,560 | BQB42F1 |
| 0.05% | XNCR | XENCOR INC | -- | $43,355.00 | 3,335 | BGCYWN8 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $42,036.78 | 2,186 | BZ7PJQ1 |
| 0.05% | CTMX | CYTOMX THERAPEUTICS INC | -- | $41,933.83 | 7,927 | BYWVTY5 |
| 0.04% | PCRX | PACIRA BIOSCIENCES INC | -- | $40,662.16 | 2,009 | B3X26D8 |
| 0.04% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $40,249.80 | 7,580 | B3MZ6K5 |
| 0.04% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $40,062.25 | 955 | BL95N25 |
| 0.04% | PSNL | PERSONALIS INC | -- | $40,018.55 | 4,147 | BJQ0608 |
| 0.04% | OMER | OMEROS CORP | -- | $39,996.88 | 3,311 | B4NB858 |
| 0.04% | GERN | GERON CORP | -- | $39,945.40 | 29,810 | 2370381 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $39,754.40 | 2,290 | BQS7491 |
| 0.04% | ARVN | ARVINAS INC | -- | $37,787.40 | 2,999 | BDZ30Q0 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $37,579.42 | 2,362 | BD06CS0 |
| 0.04% | JANX | JANUX THERAPEUTICS INC | -- | $37,275.43 | 2,809 | BMFX8Y7 |
| 0.04% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $37,272.42 | 9,003 | BZ0QMB7 |
| 0.04% | RGNX | REGENXBIO INC | -- | $35,507.28 | 2,364 | BZ0G875 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $35,438.08 | 4,064 | BYZD465 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $34,439.52 | 1,828 | BD9GVY0 |
| 0.04% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $34,119.58 | 14,099 | B4N8MH9 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $33,844.40 | 8,440 | BPBJFM7 |
| 0.04% | BIOA | BIOAGE LABS INC | -- | $33,680.88 | 1,674 | BT9K6D8 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $33,268.72 | 11,164 | BBNBTD2 |
| 0.04% | CGEM | CULLINAN THERAPEUTICS INC | -- | $32,004.40 | 2,759 | BM90J52 |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $31,918.72 | 848 | BQD3J33 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $30,800.00 | 4,400 | BMC3HS7 |
| 0.03% | GOSS | GOSSAMER BIO INC | -- | $29,674.20 | 10,830 | BJ0CK86 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $28,681.17 | 3,759 | BFYQFJ2 |
| 0.03% | IVVD | INVIVYD INC | -- | $28,599.61 | 12,941 | BM8NHS1 |
| 0.03% | LENZ | LENZ THERAPEUTICS INC | -- | $28,460.28 | 1,461 | BQV0J03 |
| 0.03% | KROS | KEROS THERAPEUTICS INC | -- | $27,065.46 | 1,423 | BM7V485 |
| 0.03% | CRMD | CORMEDIX INC | -- | $26,967.07 | 3,679 | BJ0LT31 |
| 0.03% | REPL | REPLIMUNE GROUP INC | -- | $26,593.38 | 3,663 | BDDVW37 |
| 0.03% | FULC | FULCRUM THERAPEUTICS INC | -- | $26,331.34 | 2,527 | BJDX8Z9 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $25,936.76 | 6,772 | BMCWKZ2 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $25,403.00 | 2,660 | BMFK3H6 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $24,639.84 | 3,408 | BQ6C357 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $24,335.52 | 2,514 | B91XRN2 |
| 0.03% | LYEL | LYELL IMMUNOPHARMA INC | -- | $23,902.92 | 991 | BTNMG41 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $23,739.87 | 2,629 | BLFBZ32 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $22,599.00 | 675 | B292NQ7 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $22,513.26 | 4,873 | BFY7DC4 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $22,410.08 | 3,638 | BQHN6C7 |
| 0.02% | ACRS | ACLARIS THERAPEUTICS INC | -- | $22,365.20 | 5,060 | BYV2W40 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $22,271.04 | 3,344 | 2107437 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $22,138.10 | 4,177 | BYTYP72 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $21,886.80 | 2,760 | B12W3P6 |
| 0.02% | ABSI | ABSCI CORP | -- | $21,206.44 | 7,022 | BN94K69 |
| 0.02% | KMDA | KAMADA LTD | -- | $20,986.26 | 2,694 | B2Q9833 |
| 0.02% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $20,516.92 | 2,668 | BKLXFX5 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $20,170.50 | 1,785 | BP81RK8 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $19,386.60 | 2,045 | BSMLR16 |
| 0.02% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $19,141.92 | 5,697 | BYVQJ96 |
| 0.02% | ETON | ETON PHARMACEUTICALS INC | -- | $18,992.84 | 1,252 | BGL0JK3 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $18,649.26 | 5,054 | BDFKQ07 |
| 0.02% | NBP | NOVABRIDGE BIOSCIENCES | -- | $18,400.45 | 4,855 | BKRRKY7 |
| 0.02% | PEPG | PEPGEN INC | -- | $17,366.10 | 3,210 | BMTX3D7 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $16,944.36 | 1,348 | B9L5200 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $16,792.00 | 10,495 | BFZNYB7 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $16,466.16 | 874 | BPBPCG8 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $16,253.68 | 2,966 | BP81R42 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $16,212.17 | 2,353 | B7F2TY6 |
| 0.02% | CADL | CANDEL THERAPEUTICS INC | -- | $16,153.20 | 2,564 | BP0TQC5 |
| 0.02% | AARD | AARDVARK THERAPEUTICS INC | -- | $16,088.94 | 1,017 | BTXQTX3 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $16,057.28 | 2,641 | BMF7DT9 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $15,942.60 | 4,689 | BZC0D70 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $15,215.85 | 7,803 | BN4JN37 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $14,910.90 | 2,161 | BKDQKM6 |
| 0.02% | EOLS | EVOLUS INC | -- | $14,832.30 | 3,027 | BDRJH21 |
| 0.02% | LFCR | LIFECORE BIOMEDICAL INC | -- | $14,752.50 | 1,750 | 2517058 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $14,642.15 | 3,019 | BMVBZF5 |
| 0.02% | VOR | VOR BIOPHARMA INC | -- | $14,228.96 | 787 | BRJJYT3 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $13,770.96 | 9,368 | BFMLGR4 |
| 0.01% | OABI | OMNIAB INC | -- | $13,513.23 | 6,723 | BN13S71 |
| 0.01% | LRMR | LARIMAR THERAPEUTICS INC | -- | $13,270.04 | 3,997 | BMXNGZ6 |
| 0.01% | NGNE | NEUROGENE INC | -- | $13,238.13 | 723 | BS2F741 |
| 0.01% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $13,163.80 | 1,079 | BPRBTY7 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $12,840.96 | 3,648 | BLN9Z50 |
| 0.01% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $12,456.24 | 2,193 | BL5B6Z1 |
| 0.01% | MENS | JYONG BIOTECH LTD | -- | $11,324.50 | 3,550 | BPTK6Z2 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $11,232.36 | 9,132 | BNR5QT9 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $10,785.33 | 2,637 | BPRB2N7 |
| 0.01% | CABA | CABALETTA BIO INC | -- | $10,518.30 | 4,495 | BK5MWR1 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $10,390.12 | 2,756 | BY7RB53 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $9,665.08 | 4,559 | BZ8FPH3 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $9,647.29 | 1,327 | BKC9SX3 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $9,595.12 | 4,526 | BKX9NQ0 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $9,257.80 | 5,645 | BRK0149 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $9,207.50 | 1,450 | BP2NYN2 |
| 0.01% | HUMA | HUMACYTE INC | -- | $8,570.10 | 8,745 | BMYTJP4 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $8,225.00 | 2,500 | BP7L561 |
| 0.01% | CDXS | CODEXIS INC | -- | $7,212.78 | 4,218 | B5LL2C2 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $6,838.77 | 2,661 | BKTV702 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $6,503.85 | 4,365 | BNYJR68 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $6,149.25 | 4,555 | BNNXX18 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $5,566.84 | 7,776 | BNNXX52 |
| 0.01% | PYXS | PYXIS ONCOLOGY INC | -- | $4,827.28 | 2,908 | BLBR8D5 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $15.80 | 01 | BTFHQP5 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 43.24% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 39,174,075 | -- | 6,611 | -- |
| 29.23% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 26,475,536 | -- | 4,468 | -- |
| 23.40% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 21,195,835 | -- | 3,577 | -- |
| 16.25% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,719,166 | -- | 2,484 | -- |
| 15.04% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 13,622,931 | -- | 2,299 | -- |
| 4.14% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,750,898 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $28,611,261.76 | 28,611,262 | -- |
Index
as of 12/31/2025
- Total Number of Companies262
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$7.32 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
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