BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 9/30/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 11/05/2025- NAV $70.23
- NAV Change $+1.93
- Market Price $70.19
- Market Price Change $+1.90
- Trading Volume (M) 4,190
- 30-Day Median Bid Ask Spread 0.29%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 11/05/2025- NAV $70.23
- NAV Change $+1.93
- Market Price $70.19
- Market Price Change $+1.90
- Trading Volume (M) 4,190
- 30-Day Median Bid Ask Spread 0.29%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 11/05/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.08% | AMGN | AMGEN INC | -- | $3,463,763.94 | 10,829 | 2023607 |
| 4.96% | GILD | GILEAD SCIENCES INC | -- | $3,380,756.40 | 27,580 | 2369174 |
| 4.88% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $3,322,656.00 | 7,968 | 2931034 |
| 3.68% | REGN | REGENERON PHARMACEUTICALS | -- | $2,505,899.10 | 3,890 | 2730190 |
| 3.12% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,127,171.20 | 4,895 | B00FWN1 |
| 2.32% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $1,582,262.70 | 19,498 | 2989044 |
| 2.18% | INSM | INSMED INC | -- | $1,487,377.92 | 7,959 | 2614487 |
| 1.41% | ARGX | ARGENX SE - ADR | -- | $959,699.55 | 1,153 | BDVLM39 |
| 1.24% | BIIB | BIOGEN INC | -- | $846,933.60 | 5,520 | 2455965 |
| 1.14% | INCY | INCYTE CORP | -- | $777,212.10 | 7,353 | 2471950 |
| 1.12% | UTHR | UNITED THERAPEUTICS CORP | -- | $762,007.35 | 1,703 | 2430412 |
| 1.04% | ILMN | ILLUMINA INC | -- | $708,560.28 | 5,787 | 2613990 |
| 0.97% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $657,916.34 | 16,277 | BMVP7Y0 |
| 0.93% | MEDP | MEDPACE HOLDINGS INC | -- | $632,942.17 | 1,057 | BDCBC61 |
| 0.84% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $574,102.50 | 3,734 | 2623911 |
| 0.77% | TEM | TEMPUS AI INC | -- | $522,515.52 | 6,352 | BSLSJJ0 |
| 0.76% | ROIV | ROIVANT SCIENCES LTD | -- | $520,153.76 | 25,712 | BMW4NZ9 |
| 0.74% | SMMT | SUMMIT THERAPEUTICS INC | -- | $505,399.83 | 27,969 | BMTVQS7 |
| 0.73% | SNY | SANOFI-ADR | -- | $494,998.00 | 10,102 | 2964557 |
| 0.69% | VTRS | VIATRIS INC | -- | $471,892.75 | 43,897 | BMWS3X9 |
| 0.67% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $453,045.25 | 2,291 | BV9G6B8 |
| 0.66% | BBIO | BRIDGEBIO PHARMA INC | -- | $451,026.68 | 7,198 | BK1KWG8 |
| 0.66% | IONS | IONIS PHARMACEUTICALS INC | -- | $448,229.36 | 6,002 | BDJ0LS6 |
| 0.66% | GH | GUARDANT HEALTH INC | -- | $446,259.75 | 4,695 | BFXC911 |
| 0.61% | RVMD | REVOLUTION MEDICINES INC | -- | $417,694.26 | 7,039 | BL71K91 |
| 0.60% | EXEL | EXELIXIS INC | -- | $409,190.32 | 10,136 | 2576941 |
| 0.60% | ONC | BEONE MEDICINES LTD-ADR | -- | $406,558.35 | 1,265 | BYYWPW6 |
| 0.59% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $399,254.93 | 839 | BD59BS7 |
| 0.58% | BNTX | BIONTECH SE-ADR | -- | $391,689.41 | 3,787 | BK6H543 |
| 0.56% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $381,744.00 | 7,230 | 2437071 |
| 0.51% | MRNA | MODERNA INC | -- | $345,130.44 | 14,649 | BGSXTS3 |
| 0.50% | RNA | AVIDITY BIOSCIENCES INC | -- | $338,111.20 | 4,844 | BMWHPY1 |
| 0.46% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $313,410.48 | 2,284 | B4Q5ZN4 |
| 0.44% | HALO | HALOZYME THERAPEUTICS INC | -- | $300,793.20 | 4,404 | 2975098 |
| 0.40% | MRUS | MERUS NV | -- | $271,072.64 | 2,848 | BZBY005 |
| 0.39% | CYTK | CYTOKINETICS INC | -- | $266,650.95 | 4,505 | BBBSBJ5 |
| 0.37% | AXSM | AXSOME THERAPEUTICS INC | -- | $254,825.82 | 1,878 | BYZR4X4 |
| 0.37% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $248,774.47 | 2,501 | BF2YWG4 |
| 0.34% | NUVL | NUVALENT INC-A | -- | $231,145.90 | 2,510 | BMVBZD3 |
| 0.32% | KRYS | KRYSTAL BIOTECH INC | -- | $217,869.20 | 1,090 | BD6JX35 |
| 0.32% | PTCT | PTC THERAPEUTICS INC | -- | $214,664.07 | 2,991 | B17VCN9 |
| 0.31% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $209,813.55 | 5,205 | BYQBFJ8 |
| 0.29% | PCVX | VAXCYTE INC | -- | $197,084.16 | 4,888 | BKPVGH6 |
| 0.29% | CRSP | CRISPR THERAPEUTICS AG | -- | $195,133.76 | 3,424 | BDHF4K6 |
| 0.28% | ALKS | ALKERMES PLC | -- | $193,131.12 | 6,216 | B3P6D26 |
| 0.27% | ACLX | ARCELLX INC | -- | $182,720.88 | 2,088 | BPCJ1Q2 |
| 0.27% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $182,394.96 | 2,342 | BDCBCD8 |
| 0.24% | AKRO | AKERO THERAPEUTICS INC | -- | $162,798.60 | 3,012 | BK7Y2V9 |
| 0.24% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $161,688.13 | 4,241 | BP8JSP4 |
| 0.24% | KYMR | KYMERA THERAPEUTICS INC | -- | $161,223.88 | 2,692 | BMPRZV5 |
| 0.23% | IMVT | IMMUNOVANT INC | -- | $154,910.40 | 6,564 | BJRFSB7 |
| 0.22% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $150,981.50 | 3,550 | BDD19F8 |
| 0.22% | INDV | INDIVIOR PLC | -- | $150,538.85 | 4,697 | BP0BQQ5 |
| 0.21% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $141,862.49 | 6,353 | 2713317 |
| 0.21% | LGND | LIGAND PHARMACEUTICALS | -- | $140,500.44 | 738 | 2501578 |
| 0.20% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $138,234.25 | 11,825 | BFNF1D6 |
| 0.20% | ADMA | ADMA BIOLOGICS INC | -- | $138,084.08 | 8,984 | B9NSBM2 |
| 0.20% | VCYT | VERACYTE INC | -- | $136,370.48 | 2,962 | BFTWZY0 |
| 0.19% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $132,610.28 | 1,892 | BJDX8Y8 |
| 0.19% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $130,394.88 | 792 | BQ721R4 |
| 0.17% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $115,656.23 | 3,629 | BJ62Z18 |
| 0.17% | IRON | DISC MEDICINE INC | -- | $115,597.79 | 1,309 | BMGJZJ8 |
| 0.17% | GRAL | GRAIL INC | -- | $114,856.48 | 1,357 | BSLSSX7 |
| 0.17% | TVTX | TRAVERE THERAPEUTICS INC | -- | $113,198.04 | 3,357 | BLFGJD5 |
| 0.16% | XENE | XENON PHARMACEUTICALS INC | -- | $112,229.98 | 2,903 | BRJ3GY4 |
| 0.16% | DYN | DYNE THERAPEUTICS INC | -- | $111,961.30 | 5,357 | BN15WD1 |
| 0.16% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $110,051.32 | 4,514 | BKX9VD3 |
| 0.16% | CGON | CG ONCOLOGY INC | -- | $108,983.16 | 2,871 | BRBCSP4 |
| 0.16% | TARS | TARSUS PHARMACEUTICALS INC | -- | $108,438.00 | 1,590 | BMH5RL1 |
| 0.16% | FOLD | AMICUS THERAPEUTICS INC | -- | $106,659.14 | 11,606 | B19FQ48 |
| 0.15% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $101,471.70 | 3,170 | BMX9K07 |
| 0.15% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $101,323.80 | 3,620 | BFZQ0L8 |
| 0.15% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $100,843.47 | 5,733 | BJ5FZ74 |
| 0.15% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $99,449.21 | 2,111 | B72ZBG4 |
| 0.15% | MLYS | MINERALYS THERAPEUTICS INC | -- | $98,966.40 | 2,496 | BP9N0G0 |
| 0.14% | IDYA | IDEAYA BIOSCIENCES INC | -- | $97,878.00 | 3,300 | BK0VHF6 |
| 0.14% | APGE | APOGEE THERAPEUTICS INC | -- | $96,261.20 | 1,736 | BM9HHL5 |
| 0.14% | APLS | APELLIS PHARMACEUTICALS INC | -- | $94,862.25 | 4,755 | BYTQ6X1 |
| 0.13% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $88,635.88 | 2,188 | BCBVTX1 |
| 0.13% | BEAM | BEAM THERAPEUTICS INC | -- | $87,873.63 | 3,809 | BK6L288 |
| 0.12% | DNLI | DENALI THERAPEUTICS INC | -- | $81,969.45 | 5,505 | BD2B4V0 |
| 0.12% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $81,342.24 | 3,612 | BLB0YQ9 |
| 0.12% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $79,801.44 | 16,089 | BM9FJ13 |
| 0.11% | IBRX | IMMUNITYBIO INC | -- | $76,520.65 | 35,591 | BNSP0B8 |
| 0.11% | COGT | COGENT BIOSCIENCES INC | -- | $75,834.78 | 5,259 | BLR6XK8 |
| 0.11% | ANIP | ANI PHARMACEUTICALS INC | -- | $75,670.54 | 817 | BCDWBX6 |
| 0.11% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $72,279.24 | 2,244 | BQS9486 |
| 0.11% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $71,628.65 | 4,957 | BFWLC09 |
| 0.11% | TWST | TWIST BIOSCIENCE CORP | -- | $71,613.44 | 2,272 | BGKG6G7 |
| 0.10% | OCUL | OCULAR THERAPEUTIX INC | -- | $70,816.31 | 6,551 | BNZB1X8 |
| 0.10% | VCEL | VERICEL CORP | -- | $70,680.00 | 1,900 | BSBMN89 |
| 0.10% | MNKD | MANNKIND CORP | -- | $70,017.24 | 11,554 | BF081J4 |
| 0.10% | AVDL | AVADEL PHARMACEUTICALS | -- | $69,298.80 | 3,655 | BDGMC59 |
| 0.10% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $69,063.12 | 3,976 | BKY5JZ8 |
| 0.10% | SRPT | SAREPTA THERAPEUTICS INC | -- | $68,686.93 | 3,679 | B8DPDT7 |
| 0.10% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $67,904.10 | 2,166 | BKSGZN7 |
| 0.09% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $64,072.18 | 1,637 | BRXB0C0 |
| 0.09% | JANX | JANUX THERAPEUTICS INC | -- | $62,295.48 | 2,262 | BMFX8Y7 |
| 0.09% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $60,019.47 | 6,081 | BLR7H87 |
| 0.09% | TERN | TERNS PHARMACEUTICALS INC | -- | $59,936.05 | 3,295 | BMDJ0C9 |
| 0.09% | TXG | 10X GENOMICS INC-CLASS A | -- | $58,114.92 | 4,308 | BKS3RS7 |
| 0.09% | VERA | VERA THERAPEUTICS INC | -- | $57,936.40 | 2,404 | BL55460 |
| 0.08% | ALVO | ALVOTECH SA | -- | $57,510.80 | 11,785 | BPNTJ34 |
| 0.08% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $56,671.68 | 7,904 | 2100362 |
| 0.08% | NTLA | INTELLIA THERAPEUTICS INC | -- | $54,836.37 | 4,041 | BYZM6C2 |
| 0.08% | ARDX | ARDELYX INC | -- | $53,990.30 | 9,074 | BN89V40 |
| 0.08% | QURE | UNIQURE NV | -- | $53,839.96 | 2,066 | BJFSR88 |
| 0.08% | ABCL | ABCELLERA BIOLOGICS INC | -- | $52,776.57 | 11,253 | BL53SR3 |
| 0.08% | SYRE | SPYRE THERAPEUTICS INC | -- | $51,983.75 | 2,275 | BQBBDY8 |
| 0.07% | ZYME | ZYMEWORKS INC | -- | $51,081.50 | 2,830 | BPCQZY9 |
| 0.07% | HROW | HARROW INC | -- | $49,340.06 | 1,393 | BHNDW86 |
| 0.07% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $48,969.30 | 3,243 | BN7Q7R7 |
| 0.07% | NVCR | NOVOCURE LTD | -- | $48,866.49 | 4,209 | BYSS4X4 |
| 0.07% | TRVI | TREVI THERAPEUTICS INC | -- | $48,784.40 | 4,585 | BJH9ZN0 |
| 0.07% | WVE | WAVE LIFE SCIENCES LTD | -- | $48,175.68 | 5,992 | BYZG9R0 |
| 0.07% | STOK | STOKE THERAPEUTICS INC | -- | $47,100.48 | 2,064 | BJQ05Z6 |
| 0.07% | NVAX | NOVAVAX INC | -- | $47,032.04 | 6,116 | BJDQXG4 |
| 0.07% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $46,446.40 | 1,508 | BLCD809 |
| 0.07% | GMAB | GENMAB A/S -SP ADR | -- | $46,061.82 | 1,578 | BBC9WC7 |
| 0.07% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $45,474.50 | 4,415 | BRJZSK0 |
| 0.07% | ORIC | ORIC PHARMACEUTICALS INC | -- | $45,261.28 | 3,656 | BKVDFF7 |
| 0.07% | INBX | INHIBRX BIOSCIENCES INC | -- | $44,919.42 | 546 | BNSP8K3 |
| 0.07% | PGEN | PRECIGEN INC | -- | $44,767.80 | 11,220 | BKM5C84 |
| 0.07% | CVAC | CUREVAC NV | -- | $44,684.33 | 8,479 | BN4RD42 |
| 0.07% | ZLAB | ZAI LAB LTD-ADR | -- | $44,664.80 | 1,801 | BD9GVY0 |
| 0.07% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $44,459.92 | 3,358 | BPCK358 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $44,292.50 | 1,750 | BNFWZS4 |
| 0.06% | INVA | INNOVIVA INC | -- | $43,259.79 | 2,373 | BDDXF67 |
| 0.06% | RLAY | RELAY THERAPEUTICS INC | -- | $42,522.60 | 6,492 | BN2R582 |
| 0.06% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $42,518.10 | 1,186 | BX7RSN3 |
| 0.06% | TSHA | TAYSHA GENE THERAPIES INC | -- | $41,396.16 | 10,272 | BNC1BX1 |
| 0.06% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $41,273.50 | 2,231 | BMFD115 |
| 0.06% | FTRE | FORTREA HOLDINGS INC | -- | $40,809.25 | 3,415 | BRXYZ57 |
| 0.06% | SANA | SANA BIOTECHNOLOGY INC | -- | $39,747.36 | 9,742 | BMFJJ97 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $39,637.59 | 4,593 | B8K7T65 |
| 0.06% | XNCR | XENCOR INC | -- | $38,583.45 | 2,685 | BGCYWN8 |
| 0.06% | ORKA | ORUKA THERAPEUTICS INC | -- | $38,534.41 | 1,411 | BKVF0J2 |
| 0.06% | ANAB | ANAPTYSBIO INC | -- | $37,944.00 | 1,054 | BDRW1L7 |
| 0.05% | PCRX | PACIRA BIOSCIENCES INC | -- | $36,970.20 | 1,692 | B3X26D8 |
| 0.05% | CSTL | CASTLE BIOSCIENCES INC | -- | $36,658.44 | 1,092 | BKLCWZ3 |
| 0.05% | RAPP | RAPPORT THERAPEUTICS INC | -- | $35,957.58 | 1,374 | BR3T9B6 |
| 0.05% | NRIX | NURIX THERAPEUTICS INC | -- | $35,857.95 | 2,879 | BMVLGP2 |
| 0.05% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $35,470.88 | 2,671 | BJLKVS6 |
| 0.05% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $35,262.12 | 3,858 | BLB0YH0 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $33,675.05 | 3,721 | BMCR7V2 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $33,638.02 | 1,742 | BZ7PJQ1 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $33,279.59 | 7,219 | BZ0QMB7 |
| 0.05% | MNMD | MIND MEDICINE MINDMED INC | -- | $33,033.45 | 2,865 | BPQYY97 |
| 0.05% | KURA | KURA ONCOLOGY INC | -- | $32,493.86 | 3,269 | BYZD465 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $31,562.05 | 767 | BL95N25 |
| 0.05% | TNGX | TANGO THERAPEUTICS INC | -- | $31,459.39 | 4,189 | BP2P6L0 |
| 0.05% | CRMD | CORMEDIX INC | -- | $31,370.76 | 2,811 | BJ0LT31 |
| 0.04% | TYRA | TYRA BIOSCIENCES INC | -- | $29,728.92 | 2,006 | BMVNDH9 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $28,974.00 | 6,585 | BPBJFM7 |
| 0.04% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $28,633.06 | 2,326 | BP7KZP7 |
| 0.04% | EYPT | EYEPOINT PHARMACEUTICALS INC | -- | $28,583.93 | 2,595 | BMGS7L1 |
| 0.04% | TBPH | THERAVANCE BIOPHARMA INC | -- | $28,345.20 | 1,896 | BMNDK09 |
| 0.04% | VIR | VIR BIOTECHNOLOGY INC | -- | $28,247.40 | 5,231 | BK4PZ38 |
| 0.04% | AVBP | ARRIVENT BIOPHARMA INC | -- | $27,989.91 | 1,527 | BMGTLY5 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $27,630.12 | 1,778 | BQS7491 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $27,336.00 | 4,556 | BYVQJ96 |
| 0.04% | ATXS | ASTRIA THERAPEUTICS INC | -- | $26,817.50 | 2,125 | BMYRFN8 |
| 0.04% | ARVN | ARVINAS INC | -- | $26,451.48 | 2,764 | BDZ30Q0 |
| 0.04% | SVRA | SAVARA INC | -- | $26,227.24 | 6,508 | BYXGN81 |
| 0.04% | GERN | GERON CORP | -- | $26,185.07 | 24,023 | 2370381 |
| 0.04% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $25,988.82 | 3,029 | BFYQFJ2 |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $25,586.60 | 676 | BQD3J33 |
| 0.04% | PSNL | PERSONALIS INC | -- | $25,576.74 | 3,339 | BJQ0608 |
| 0.04% | REPL | REPLIMUNE GROUP INC | -- | $25,216.62 | 2,939 | BDDVW37 |
| 0.04% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $24,663.06 | 13,626 | BF0DMK7 |
| 0.04% | KROS | KEROS THERAPEUTICS INC | -- | $23,928.85 | 1,529 | BM7V485 |
| 0.03% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $23,640.54 | 3,234 | BYTYP72 |
| 0.03% | ERAS | ERASCA INC | -- | $23,500.40 | 10,682 | BNLYBF3 |
| 0.03% | LENZ | LENZ THERAPEUTICS INC | -- | $23,058.78 | 1,074 | BQV0J03 |
| 0.03% | SIGA | SIGA TECHNOLOGIES INC | -- | $22,744.14 | 2,698 | 2107437 |
| 0.03% | ESPR | ESPERION THERAPEUTICS INC | -- | $22,320.48 | 7,592 | BBNBTD2 |
| 0.03% | RGNX | REGENXBIO INC | -- | $22,082.22 | 1,902 | BZ0G875 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $21,658.65 | 11,310 | B4N8MH9 |
| 0.03% | ABSI | ABSCI CORP | -- | $21,454.11 | 5,631 | BN94K69 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $21,287.98 | 2,114 | BLFBZ32 |
| 0.03% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $21,129.18 | 2,806 | BYP80F1 |
| 0.03% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $20,837.04 | 1,896 | BD06CS0 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $20,817.29 | 2,027 | B91XRN2 |
| 0.03% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $20,542.80 | 2,584 | BMZ4LN0 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $18,956.97 | 3,453 | BMC3HS7 |
| 0.03% | LXRX | LEXICON PHARMACEUTICALS INC | -- | $18,882.54 | 13,683 | BWFZX59 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $18,487.09 | 1,759 | BKLXFX5 |
| 0.03% | HCM | HUTCHMED CHINA-ADR | -- | $18,185.76 | 1,168 | BYXV9H7 |
| 0.03% | OMER | OMEROS CORP | -- | $17,915.37 | 2,563 | B4NB858 |
| 0.02% | ALMS | ALUMIS INC | -- | $16,671.36 | 3,648 | BPLQG36 |
| 0.02% | LXEO | LEXEO THERAPEUTICS INC | -- | $16,670.60 | 2,033 | BQ6C357 |
| 0.02% | EOLS | EVOLUS INC | -- | $16,589.16 | 2,436 | BDRJH21 |
| 0.02% | CGEM | CULLINAN THERAPEUTICS INC | -- | $16,264.75 | 2,225 | BM90J52 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $16,110.71 | 539 | B292NQ7 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $15,979.38 | 6,099 | BN4JN37 |
| 0.02% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $15,638.63 | 5,449 | BMCWKZ2 |
| 0.02% | NGNE | NEUROGENE INC | -- | $14,885.64 | 537 | BS2F741 |
| 0.02% | DSGN | DESIGN THERAPEUTICS INC | -- | $14,049.75 | 2,145 | BMFK3H6 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $13,492.48 | 4,064 | BDFKQ07 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $12,968.83 | 3,781 | BZC0D70 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $12,729.60 | 2,340 | BP81R42 |
| 0.02% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $12,601.02 | 6,117 | B3MZ6K5 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $12,465.00 | 3,324 | BFY7DC4 |
| 0.02% | ANNX | ANNEXON INC | -- | $12,458.39 | 4,139 | BMVV9R5 |
| 0.02% | LYEL | LYELL IMMUNOPHARMA INC | -- | $11,974.96 | 724 | BTNMG41 |
| 0.02% | AMRN | AMARIN CORP PLC -ADR | -- | $11,620.29 | 759 | BN72KB0 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $11,573.76 | 704 | BPBPCG8 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $11,522.76 | 2,932 | BQHN6C7 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $11,321.55 | 1,629 | BSMLR16 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $11,032.32 | 1,768 | BL5B6Z1 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $10,741.97 | 1,741 | BKDQKM6 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $10,459.52 | 7,552 | BFMLGR4 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $10,378.06 | 3,223 | BMXNGZ6 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $9,974.25 | 2,015 | BP7L561 |
| 0.01% | TRDA | ENTRADA THERAPEUTICS INC | -- | $9,945.02 | 1,433 | BP81RK8 |
| 0.01% | VNDA | VANDA PHARMACEUTICALS INC | -- | $9,879.00 | 2,225 | B12W3P6 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $9,681.12 | 2,988 | BLN9Z50 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $9,413.08 | 3,386 | BZ8FPH3 |
| 0.01% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $9,274.05 | 8,355 | BFZNYB7 |
| 0.01% | PYXS | PYXIS ONCOLOGY INC | -- | $9,133.76 | 2,336 | BLBR8D5 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $8,920.03 | 2,089 | BY7RB53 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $8,838.72 | 1,023 | BKC9SX3 |
| 0.01% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $8,790.60 | 805 | B9L5200 |
| 0.01% | HUMA | HUMACYTE INC | -- | $8,647.80 | 5,964 | BMYTJP4 |
| 0.01% | FHTX | FOGHORN THERAPEUTICS INC | -- | $8,516.00 | 2,129 | BMF7DT9 |
| 0.01% | RNAC | CARTESIAN THERAPEUTICS INC | -- | $7,508.93 | 979 | BQB9HM8 |
| 0.01% | CDXS | CODEXIS INC | -- | $7,307.85 | 3,399 | B5LL2C2 |
| 0.01% | MXCT | MAXCYTE INC | -- | $6,705.05 | 4,015 | BKMQF66 |
| 0.01% | OABI | OMNIAB INC | -- | $6,584.93 | 4,621 | BN13S71 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $6,353.97 | 2,681 | BKX9NQ0 |
| 0.01% | PEPG | PEPGEN INC | -- | $5,606.90 | 1,235 | BMTX3D7 |
| 0.01% | NKTX | NKARTA INC | -- | $5,216.25 | 2,675 | BK80YJ8 |
| 0.01% | CLYM | CLIMB BIO INC | -- | $4,899.84 | 2,552 | BMW5LX6 |
| 0.01% | APLT | APPLIED THERAPEUTICS INC | -- | $4,827.01 | 5,423 | BJL38Z1 |
| 0.01% | ALEC | ALECTOR INC | -- | $4,784.06 | 3,812 | BJ4LDC4 |
| 0.01% | FATE | FATE THERAPEUTICS INC | -- | $4,733.87 | 4,343 | BCZS820 |
| 0.01% | TVGN | TEVOGEN BIO HOLDINGS INC | -- | $3,888.68 | 7,407 | BPG5P75 |
| 0.01% | PLRX | PLIANT THERAPEUTICS INC | -- | $3,791.68 | 2,312 | BMDWW66 |
| 0.01% | MGNX | MACROGENICS INC | -- | $3,428.64 | 2,381 | BFDV8K0 |
| -- | ARTV | ARTIVA BIOTHERAPEUTICS INC | -- | $3,164.80 | 920 | BMF1LJ7 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $3,143.22 | 3,194 | BF12XC2 |
| -- | BMEA | BIOMEA FUSION INC | -- | $3,004.28 | 2,242 | BNKF6N0 |
| -- | ACRV | ACRIVON THERAPEUTICS INC | -- | $2,405.55 | 1,185 | BP2TPK4 |
| -- | TCRX | TSCAN THERAPEUTICS INC | -- | $2,243.90 | 1,977 | BNLYBJ7 |
| -- | MRSN | MERSANA THERAPEUTICS INC | -- | $1,598.94 | 189 | BVPKH99 |
| -- | OKUR | ONKURE THERAPEUTICS INC-A | -- | $1,452.00 | 484 | BT7KGT6 |
| -- | QTTB | Q32 BIO INC | -- | $1,101.79 | 461 | BS2FKQ4 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 37.00% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 25,206,761 | -- | 4,737 | -- |
| 28.19% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 19,204,391 | -- | 3,609 | -- |
| 24.62% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 16,772,580 | -- | 3,152 | -- |
| 19.40% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 13,217,985 | -- | 2,484 | -- |
| 17.96% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 12,233,554 | -- | 2,299 | -- |
| 9.02% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 6,146,044 | -- | 1,155 | -- |
| -- | -- | TREASURY BILL | -- | $4,992,613.05 | 5,000,000 | BMGHP58 |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $19,373,119.40 | 19,373,119 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
Read More