BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 2/28/2026
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 6.03% | 5.70% | 60.37% | 10.56% | 62.26% | 19.25% | -0.31% | 8.72% | 16.98% | 04/07/2010 |
| BIB Market Price | 6.05% | 5.51% | 60.28% | 10.49% | 62.05% | 19.26% | -0.28% | 8.72% | 16.98% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | -4.51% | 34.14% | 74.98% | 59.23% | 59.23% | 12.41% | -1.02% | 1.38% | 16.43% | 04/07/2010 |
| BIB NAV | -4.39% | 34.17% | 75.09% | 59.34% | 59.34% | 12.29% | -1.01% | 1.39% | 16.43% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 3/06/2026- NAV $80.74
- NAV Change $-1.11
- Market Price $80.74
- Market Price Change $-1.04
- Trading Volume (M) 10,135
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 3/06/2026- NAV $80.74
- NAV Change $-1.11
- Market Price $80.74
- Market Price Change $-1.04
- Trading Volume (M) 10,135
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 12/31/2025
Holdings
as of 3/06/2026
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 6.78% | GILD | GILEAD SCIENCES INC | -- | $5,584,196.14 | 38,798 | 2369174 |
| 6.34% | AMGN | AMGEN INC | -- | $5,222,937.02 | 14,134 | 2023607 |
| 6.24% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $5,141,872.71 | 11,259 | 2931034 |
| 4.28% | REGN | REGENERON PHARMACEUTICALS | -- | $3,523,470.82 | 4,637 | 2730190 |
| 2.31% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $1,901,834.46 | 5,931 | B00FWN1 |
| 1.63% | INSM | INSMED INC | -- | $1,341,604.62 | 9,574 | 2614487 |
| 1.48% | BIIB | BIOGEN INC | -- | $1,217,553.82 | 6,586 | 2455965 |
| 1.14% | ARGX | ARGENX SE - ADR | -- | $937,446.80 | 1,306 | BDVLM39 |
| 1.12% | UTHR | UNITED THERAPEUTICS CORP | -- | $923,805.12 | 1,932 | 2430412 |
| 1.12% | MRNA | MODERNA INC | -- | $921,148.28 | 17,539 | BGSXTS3 |
| 1.09% | ROIV | ROIVANT SCIENCES LTD | -- | $898,626.72 | 31,224 | BMW4NZ9 |
| 1.06% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $871,100.03 | 19,183 | BMVP7Y0 |
| 1.04% | ILMN | ILLUMINA INC | -- | $854,768.58 | 6,859 | 2613990 |
| 1.04% | RVMD | REVOLUTION MEDICINES INC | -- | $854,013.60 | 8,679 | BL71K91 |
| 1.03% | INCY | INCYTE CORP | -- | $845,519.22 | 8,813 | 2471950 |
| 0.88% | VTRS | VIATRIS INC | -- | $725,994.36 | 51,709 | BMWS3X9 |
| 0.81% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $663,472.05 | 2,757 | BV9G6B8 |
| 0.72% | MEDP | MEDPACE HOLDINGS INC | -- | $595,296.35 | 1,265 | BDCBC61 |
| 0.70% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $573,509.88 | 4,476 | 2623911 |
| 0.69% | BBIO | BRIDGEBIO PHARMA INC | -- | $565,429.36 | 8,651 | BK1KWG8 |
| 0.65% | IONS | IONIS PHARMACEUTICALS INC | -- | $538,344.84 | 7,271 | BDJ0LS6 |
| 0.64% | GH | GUARDANT HEALTH INC | -- | $529,689.60 | 5,808 | BFXC911 |
| 0.64% | SNY | SANOFI-ADR | -- | $529,298.55 | 11,881 | 2964557 |
| 0.64% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $527,160.00 | 8,625 | 2437071 |
| 0.61% | SMMT | SUMMIT THERAPEUTICS INC | -- | $505,021.53 | 33,423 | BMTVQS7 |
| 0.61% | EXEL | EXELIXIS INC | -- | $500,077.17 | 12,037 | 2576941 |
| 0.60% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $496,523.28 | 2,728 | B4Q5ZN4 |
| 0.56% | BNTX | BIONTECH SE-ADR | -- | $460,708.50 | 4,539 | BK6H543 |
| 0.54% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $440,620.94 | 1,018 | BD59BS7 |
| 0.52% | ONC | BEONE MEDICINES LTD-ADR | -- | $425,783.68 | 1,414 | BYYWPW6 |
| 0.49% | TEM | TEMPUS AI INC-CL A | -- | $405,537.60 | 7,760 | BSLSJJ0 |
| 0.47% | IBRX | IMMUNITYBIO INC | -- | $383,396.07 | 44,221 | BNSP0B8 |
| 0.45% | AXSM | AXSOME THERAPEUTICS INC | -- | $367,352.79 | 2,263 | BYZR4X4 |
| 0.44% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $364,722.54 | 6,097 | BYQBFJ8 |
| 0.43% | HALO | HALOZYME THERAPEUTICS INC | -- | $355,713.60 | 5,280 | 2975098 |
| 0.42% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $348,927.33 | 1,123 | BQ721R4 |
| 0.42% | PCVX | VAXCYTE INC | -- | $348,388.04 | 5,876 | BKPVGH6 |
| 0.40% | CYTK | CYTOKINETICS INC | -- | $331,650.90 | 5,490 | BBBSBJ5 |
| 0.40% | KRYS | KRYSTAL BIOTECH INC | -- | $330,050.69 | 1,301 | BD6JX35 |
| 0.39% | NUVL | NUVALENT INC-A | -- | $322,386.63 | 3,243 | BMVBZD3 |
| 0.36% | ACLX | ARCELLX INC | -- | $296,800.68 | 2,596 | BPCJ1Q2 |
| 0.35% | ABVX | ABIVAX SA-ADR | -- | $289,724.50 | 2,650 | BLC89B2 |
| 0.34% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $280,185.92 | 2,996 | BF2YWG4 |
| 0.33% | KYMR | KYMERA THERAPEUTICS INC | -- | $269,672.70 | 3,230 | BMPRZV5 |
| 0.31% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $258,496.63 | 2,807 | BDCBCD8 |
| 0.31% | COGT | COGENT BIOSCIENCES INC | -- | $255,555.36 | 6,892 | BLR6XK8 |
| 0.29% | CRSP | CRISPR THERAPEUTICS AG | -- | $241,707.00 | 4,278 | BDHF4K6 |
| 0.29% | CAI | CARIS LIFE SCIENCES INC | -- | $235,479.53 | 12,667 | BT18HP9 |
| 0.27% | PTCT | PTC THERAPEUTICS INC | -- | $226,466.10 | 3,605 | B17VCN9 |
| 0.27% | CGON | CG ONCOLOGY INC | -- | $224,067.48 | 3,621 | BRBCSP4 |
| 0.26% | ALKS | ALKERMES PLC | -- | $212,205.56 | 7,412 | B3P6D26 |
| 0.25% | IMVT | IMMUNOVANT INC | -- | $209,814.20 | 7,870 | BJRFSB7 |
| 0.25% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $207,428.20 | 4,580 | BFZQ0L8 |
| 0.24% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $199,094.10 | 2,307 | BJDX8Y8 |
| 0.24% | FOLD | AMICUS THERAPEUTICS INC | -- | $198,652.02 | 13,853 | B19FQ48 |
| 0.24% | ERAS | ERASCA INC | -- | $197,041.39 | 12,737 | BNLYBF3 |
| 0.23% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $186,869.36 | 14,114 | BFNF1D6 |
| 0.22% | INDV | INDIVIOR PHARMACEUTICALS INC | -- | $180,808.81 | 5,603 | BTZRLN8 |
| 0.22% | APGE | APOGEE THERAPEUTICS INC | -- | $179,849.10 | 2,462 | BM9HHL5 |
| 0.22% | LGND | LIGAND PHARMACEUTICALS | -- | $178,277.70 | 883 | 2501578 |
| 0.21% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $173,190.00 | 3,000 | BQS9486 |
| 0.21% | TERN | TERNS PHARMACEUTICALS INC | -- | $173,164.08 | 4,044 | BMDJ0C9 |
| 0.20% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $168,327.36 | 7,596 | 2713317 |
| 0.20% | ADMA | ADMA BIOLOGICS INC | -- | $164,457.54 | 10,686 | B9NSBM2 |
| 0.20% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $162,859.80 | 4,260 | BDD19F8 |
| 0.18% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $151,987.40 | 5,090 | BP8JSP4 |
| 0.18% | XENE | XENON PHARMACEUTICALS INC | -- | $145,531.80 | 3,470 | BRJ3GY4 |
| 0.17% | SYRE | SPYRE THERAPEUTICS INC | -- | $139,842.45 | 3,483 | BQBBDY8 |
| 0.17% | TARS | TARSUS PHARMACEUTICALS INC | -- | $139,706.82 | 1,907 | BMH5RL1 |
| 0.17% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $138,661.38 | 2,574 | B72ZBG4 |
| 0.16% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $132,228.46 | 4,753 | BKY5JZ8 |
| 0.16% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $132,000.00 | 5,500 | BKX9VD3 |
| 0.16% | IDYA | IDEAYA BIOSCIENCES INC | -- | $130,635.84 | 3,936 | BK0VHF6 |
| 0.16% | DNLI | DENALI THERAPEUTICS INC | -- | $129,638.96 | 6,584 | BD2B4V0 |
| 0.16% | TWST | TWIST BIOSCIENCE CORP | -- | $128,850.30 | 2,745 | BGKG6G7 |
| 0.15% | BEAM | BEAM THERAPEUTICS INC | -- | $120,889.70 | 4,555 | BK6L288 |
| 0.15% | VCYT | VERACYTE INC | -- | $120,099.80 | 3,548 | BFTWZY0 |
| 0.14% | ALMS | ALUMIS INC | -- | $117,418.50 | 4,365 | BPLQG36 |
| 0.14% | APLS | APELLIS PHARMACEUTICALS INC | -- | $113,937.39 | 5,677 | BYTQ6X1 |
| 0.14% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $112,389.45 | 4,331 | BLB0YQ9 |
| 0.14% | VERA | VERA THERAPEUTICS INC | -- | $112,052.76 | 2,868 | BL55460 |
| 0.13% | TVTX | TRAVERE THERAPEUTICS INC | -- | $109,423.08 | 4,017 | BLFGJD5 |
| 0.13% | TXG | 10X GENOMICS INC-CLASS A | -- | $108,815.49 | 5,229 | BKS3RS7 |
| 0.13% | IRON | DISC MEDICINE INC | -- | $103,761.28 | 1,696 | BMGJZJ8 |
| 0.12% | TNGX | TANGO THERAPEUTICS INC | -- | $102,496.65 | 6,047 | BP2P6L0 |
| 0.12% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $101,835.58 | 6,853 | BJ5FZ74 |
| 0.12% | WVE | WAVE LIFE SCIENCES LTD | -- | $98,518.08 | 7,509 | BYZG9R0 |
| 0.12% | OCUL | OCULAR THERAPEUTIX INC | -- | $98,232.55 | 9,565 | BNZB1X8 |
| 0.12% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $97,710.80 | 4,609 | BLB0YH0 |
| 0.12% | MAZE | MAZE THERAPEUTICS INC | -- | $96,832.80 | 2,160 | BSRK699 |
| 0.12% | DYN | DYNE THERAPEUTICS INC | -- | $95,297.18 | 6,413 | BN15WD1 |
| 0.11% | MLYS | MINERALYS THERAPEUTICS INC | -- | $94,447.68 | 3,552 | BP9N0G0 |
| 0.11% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $93,612.48 | 2,028 | BRXB0C0 |
| 0.11% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $92,033.75 | 4,331 | BJ62Z18 |
| 0.11% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $91,426.86 | 17,822 | BF0DMK7 |
| 0.11% | STOK | STOKE THERAPEUTICS INC | -- | $90,970.72 | 2,564 | BJQ05Z6 |
| 0.11% | GRAL | GRAIL INC | -- | $87,902.50 | 1,750 | BSLSSX7 |
| 0.10% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $86,117.14 | 3,902 | BN7Q7R7 |
| 0.10% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $84,774.40 | 5,920 | BFWLC09 |
| 0.10% | TYRA | TYRA BIOSCIENCES INC | -- | $83,955.84 | 2,396 | BMVNDH9 |
| 0.10% | ZYME | ZYMEWORKS INC | -- | $80,908.80 | 3,360 | BPCQZY9 |
| 0.10% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $80,152.96 | 9,452 | 2100362 |
| 0.10% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $79,874.10 | 23,085 | BM9FJ13 |
| 0.10% | SRPT | SAREPTA THERAPEUTICS INC | -- | $78,603.84 | 4,704 | B8DPDT7 |
| 0.10% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $78,457.60 | 2,665 | BMFD115 |
| 0.09% | DFTX | DEFINIUM THERAPEUTICS INC | -- | $78,092.52 | 4,422 | BV2DHY6 |
| 0.09% | RLAY | RELAY THERAPEUTICS INC | -- | $76,954.09 | 7,781 | BN2R582 |
| 0.09% | TRVI | TREVI THERAPEUTICS INC | -- | $76,568.10 | 5,757 | BJH9ZN0 |
| 0.09% | VCEL | VERICEL CORP | -- | $76,555.41 | 2,271 | BSBMN89 |
| 0.09% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $76,114.60 | 3,532 | BMZ4LN0 |
| 0.09% | ANIP | ANI PHARMACEUTICALS INC | -- | $74,706.36 | 1,009 | BCDWBX6 |
| 0.09% | PHVS | PHARVARIS NV | -- | $74,517.16 | 2,876 | BMZ2X38 |
| 0.09% | INVA | INNOVIVA INC | -- | $73,954.71 | 3,357 | BDDXF67 |
| 0.09% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $73,261.38 | 2,586 | BKSGZN7 |
| 0.09% | NVAX | NOVAVAX INC | -- | $72,814.08 | 7,296 | BJDQXG4 |
| 0.09% | SION | SIONNA THERAPEUTICS INC | -- | $71,967.79 | 2,003 | BQKXDX4 |
| 0.09% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $71,916.46 | 2,618 | BCBVTX1 |
| 0.09% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $71,706.60 | 3,780 | BMX9K07 |
| 0.09% | ORKA | ORUKA THERAPEUTICS INC | -- | $71,676.78 | 2,174 | BKVF0J2 |
| 0.09% | GMAB | GENMAB A/S -SP ADR | -- | $71,032.50 | 2,625 | BBC9WC7 |
| 0.08% | NTLA | INTELLIA THERAPEUTICS INC | -- | $69,888.00 | 5,200 | BYZM6C2 |
| 0.08% | ANAB | ANAPTYSBIO INC | -- | $68,819.22 | 1,242 | BDRW1L7 |
| 0.08% | NRIX | NURIX THERAPEUTICS INC | -- | $68,705.00 | 4,550 | BMVLGP2 |
| 0.08% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $68,294.35 | 4,931 | BPCK358 |
| 0.08% | ARDX | ARDELYX INC | -- | $67,520.52 | 10,908 | BN89V40 |
| 0.08% | NVCR | NOVOCURE LTD | -- | $65,552.08 | 5,027 | BYSS4X4 |
| 0.08% | RAPP | RAPPORT THERAPEUTICS INC | -- | $64,683.36 | 2,139 | BR3T9B6 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $64,529.46 | 1,959 | BLCD809 |
| 0.07% | MBX | MBX BIOSCIENCES INC | -- | $61,558.25 | 2,015 | BQXJKH2 |
| 0.07% | ZBIO | ZENAS BIOPHARMA INC | -- | $60,924.80 | 2,410 | BQB42H3 |
| 0.07% | HROW | HARROW INC | -- | $60,413.70 | 1,662 | BHNDW86 |
| 0.07% | ORIC | ORIC PHARMACEUTICALS INC | -- | $59,953.83 | 4,373 | BKVDFF7 |
| 0.07% | VIR | VIR BIOTECHNOLOGY INC | -- | $59,649.30 | 6,246 | BK4PZ38 |
| 0.07% | KOD | KODIAK SCIENCES INC | -- | $59,216.52 | 2,382 | BFXC933 |
| 0.07% | EYPT | EYEPOINT INC | -- | $58,527.00 | 3,716 | BMGS7L1 |
| 0.07% | SEPN | SEPTERNA INC | -- | $57,819.02 | 2,009 | BQNKXX2 |
| 0.07% | ALVO | ALVOTECH SA | -- | $56,356.54 | 14,054 | BPNTJ34 |
| 0.07% | TSHA | TAYSHA GENE THERAPIES INC | -- | $56,201.86 | 12,298 | BNC1BX1 |
| 0.07% | ATAI | ATAIBECKLEY INC | -- | $55,277.34 | 16,306 | BWJDYK1 |
| 0.06% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $52,960.64 | 3,353 | BYP80F1 |
| 0.06% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $52,951.80 | 1,420 | BX7RSN3 |
| 0.06% | PGEN | PRECIGEN INC | -- | $52,741.52 | 15,886 | BKM5C84 |
| 0.06% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $52,029.40 | 2,923 | BP7KZP7 |
| 0.06% | SVRA | SAVARA INC | -- | $48,141.45 | 9,135 | BYXGN81 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $47,047.43 | 5,477 | B8K7T65 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $46,361.10 | 13,438 | BL53SR3 |
| 0.06% | BCAX | BICARA THERAPEUTICS INC | -- | $45,436.20 | 2,460 | BQB42F1 |
| 0.05% | INBX | INHIBRX BIOSCIENCES INC | -- | $45,243.72 | 654 | BNSP8K3 |
| 0.05% | GHRS | GH RESEARCH PLC | -- | $44,349.12 | 2,784 | BP6C0S2 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $44,086.40 | 920 | BL95N25 |
| 0.05% | GERN | GERON CORP | -- | $43,846.74 | 28,658 | 2370381 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $43,439.22 | 1,854 | BMGTLY5 |
| 0.05% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $43,284.50 | 7,450 | BLR7H87 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $43,006.92 | 2,102 | BZ7PJQ1 |
| 0.05% | PCRX | PACIRA BIOSCIENCES INC | -- | $42,460.00 | 1,930 | B3X26D8 |
| 0.05% | CGEM | CULLINAN THERAPEUTICS INC | -- | $41,742.48 | 2,652 | BM90J52 |
| 0.05% | SPRY | ARS PHARMACEUTICALS INC | -- | $40,208.28 | 4,438 | BMCR7V2 |
| 0.05% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $39,917.76 | 2,064 | BNFWZS4 |
| 0.05% | QURE | UNIQURE NV | -- | $39,913.19 | 2,797 | BJFSR88 |
| 0.05% | FTRE | FORTREA HOLDINGS INC | -- | $39,862.28 | 4,148 | BRXYZ57 |
| 0.05% | ARVN | ARVINAS INC | -- | $39,208.80 | 2,883 | BDZ30Q0 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $39,116.55 | 8,635 | BZ0QMB7 |
| 0.05% | SANA | SANA BIOTECHNOLOGY INC | -- | $37,674.00 | 11,960 | BMFJJ97 |
| 0.05% | JANX | JANUX THERAPEUTICS INC | -- | $37,381.84 | 2,701 | BMFX8Y7 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $36,842.10 | 2,270 | BD06CS0 |
| 0.04% | OMER | OMEROS CORP | -- | $36,743.36 | 3,184 | B4NB858 |
| 0.04% | XNCR | XENCOR INC | -- | $36,291.92 | 3,206 | BGCYWN8 |
| 0.04% | MNKD | MANNKIND CORP | -- | $35,981.46 | 13,786 | BF081J4 |
| 0.04% | CTMX | CYTOMX THERAPEUTICS INC | -- | $35,600.76 | 7,607 | BYWVTY5 |
| 0.04% | CSTL | CASTLE BIOSCIENCES INC | -- | $35,527.20 | 1,310 | BKLCWZ3 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $34,997.76 | 3,906 | BYZD465 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $34,901.70 | 2,202 | BQS7491 |
| 0.04% | ZLAB | ZAI LAB LTD-ADR | -- | $34,351.32 | 1,758 | BD9GVY0 |
| 0.04% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $34,069.31 | 3,193 | BJLKVS6 |
| 0.04% | ANNX | ANNEXON INC | -- | $33,524.52 | 6,497 | BMVV9R5 |
| 0.04% | BIOA | BIOAGE LABS INC | -- | $32,666.90 | 1,610 | BT9K6D8 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $32,493.03 | 8,103 | BPBJFM7 |
| 0.04% | PSNL | PERSONALIS INC | -- | $31,258.08 | 3,987 | BJQ0608 |
| 0.04% | TBPH | THERAVANCE BIOPHARMA INC | -- | $30,885.32 | 2,276 | BMNDK09 |
| 0.04% | TECX | TECTONIC THERAPEUTIC INC | -- | $30,130.80 | 840 | BPBPCG8 |
| 0.04% | ESPR | ESPERION THERAPEUTICS INC | -- | $29,191.04 | 10,732 | BBNBTD2 |
| 0.03% | REPL | REPLIMUNE GROUP INC | -- | $28,422.54 | 3,522 | BDDVW37 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $27,839.98 | 4,231 | BMC3HS7 |
| 0.03% | DSGN | DESIGN THERAPEUTICS INC | -- | $25,707.90 | 2,558 | BMFK3H6 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $25,564.00 | 7,304 | B3MZ6K5 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $25,291.00 | 3,613 | BFYQFJ2 |
| 0.03% | SLDB | SOLID BIOSCIENCES INC | -- | $23,611.50 | 3,498 | BQHN6C7 |
| 0.03% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $23,500.18 | 814 | BQD3J33 |
| 0.03% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $23,204.70 | 10,089 | BFZNYB7 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $23,179.03 | 2,417 | B91XRN2 |
| 0.03% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $23,112.94 | 5,477 | BYVQJ96 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $23,110.50 | 6,510 | BMCWKZ2 |
| 0.03% | KMDA | KAMADA LTD | -- | $22,947.40 | 2,590 | B2Q9833 |
| 0.03% | CRMD | CORMEDIX INC | -- | $22,855.48 | 3,538 | BJ0LT31 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $22,701.44 | 2,528 | BLFBZ32 |
| 0.03% | NMRA | NEUMORA THERAPEUTICS INC | -- | $22,653.02 | 7,501 | BN4JN37 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $22,440.60 | 3,276 | BQ6C357 |
| 0.03% | IVVD | INVIVYD INC | -- | $22,395.60 | 12,442 | BM8NHS1 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $21,742.72 | 2,564 | BKLXFX5 |
| 0.03% | TRDA | ENTRADA THERAPEUTICS INC | -- | $21,599.86 | 1,717 | BP81RK8 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $21,398.00 | 650 | B292NQ7 |
| 0.03% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $21,397.32 | 4,852 | BDFKQ07 |
| 0.03% | LYEL | LYELL IMMUNOPHARMA INC | -- | $21,359.46 | 951 | BTNMG41 |
| 0.03% | VNDA | VANDA PHARMACEUTICALS INC | -- | $20,932.17 | 2,653 | B12W3P6 |
| 0.03% | AVIR | ATEA PHARMACEUTICALS INC | -- | $20,656.23 | 3,507 | BLN9Z50 |
| 0.02% | ETON | ETON PHARMACEUTICALS INC | -- | $20,244.00 | 1,205 | BGL0JK3 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $20,060.46 | 3,843 | BMXNGZ6 |
| 0.02% | FULC | FULCRUM THERAPEUTICS INC | -- | $19,844.93 | 2,429 | BJDX8Z9 |
| 0.02% | RGNX | REGENXBIO INC | -- | $19,661.45 | 2,273 | BZ0G875 |
| 0.02% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $18,705.90 | 13,555 | B4N8MH9 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $18,651.15 | 4,011 | BYTYP72 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $18,647.00 | 3,215 | 2107437 |
| 0.02% | UPB | UPSTREAM BIO INC | -- | $18,575.50 | 2,425 | BRCFFK6 |
| 0.02% | PEPG | PEPGEN INC | -- | $17,549.60 | 3,087 | BMTX3D7 |
| 0.02% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $17,547.84 | 1,296 | B9L5200 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $16,584.90 | 4,685 | BFY7DC4 |
| 0.02% | LENZ | LENZ THERAPEUTICS INC | -- | $16,396.35 | 1,405 | BQV0J03 |
| 0.02% | NBP | NOVABRIDGE BIOSCIENCES | -- | $16,334.50 | 4,667 | BKRRKY7 |
| 0.02% | EOLS | EVOLUS INC | -- | $16,097.83 | 2,911 | BDRJH21 |
| 0.02% | ABSI | ABSCI CORP | -- | $16,069.76 | 6,752 | BN94K69 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $15,960.00 | 2,850 | BP81R42 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $15,932.70 | 1,967 | BSMLR16 |
| 0.02% | KROS | KEROS THERAPEUTICS INC | -- | $15,458.40 | 1,368 | BM7V485 |
| 0.02% | IMRX | IMMUNEERING CORP - CLASS A | -- | $15,451.67 | 2,899 | BMVBZF5 |
| 0.02% | NGNE | NEUROGENE INC | -- | $15,408.15 | 695 | BS2F741 |
| 0.02% | ACRS | ACLARIS THERAPEUTICS INC | -- | $14,886.90 | 4,865 | BYV2W40 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $14,675.42 | 2,539 | BMF7DT9 |
| 0.02% | CTNM | CONTINEUM THERAPEUTICS INC-A | -- | $14,393.56 | 1,037 | BPRBTY7 |
| 0.02% | CABA | CABALETTA BIO INC | -- | $13,697.57 | 4,321 | BK5MWR1 |
| 0.02% | PBYI | PUMA BIOTECHNOLOGY INC | -- | $13,685.10 | 2,262 | B7F2TY6 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $13,599.06 | 9,006 | BFMLGR4 |
| 0.02% | CCCC | C4 THERAPEUTICS INC | -- | $13,227.04 | 4,351 | BKX9NQ0 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $13,139.07 | 2,109 | BL5B6Z1 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $12,577.32 | 4,508 | BZC0D70 |
| 0.01% | OABI | OMNIAB INC | -- | $12,215.07 | 6,463 | BN13S71 |
| 0.01% | CADL | CANDEL THERAPEUTICS INC | -- | $12,177.10 | 2,465 | BP0TQC5 |
| 0.01% | LFCR | LIFECORE BIOMEDICAL INC | -- | $11,706.72 | 1,682 | 2517058 |
| 0.01% | VOR | VOR BIOPHARMA INC | -- | $11,430.72 | 756 | BRJJYT3 |
| 0.01% | OBIO | ORCHESTRA BIOMED HOLDINGS IN | -- | $10,951.20 | 2,535 | BPRB2N7 |
| 0.01% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $10,795.20 | 2,076 | BKDQKM6 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $10,315.50 | 2,645 | BY7RB53 |
| 0.01% | CHRS | COHERUS ONCOLOGY INC | -- | $9,877.14 | 5,427 | BRK0149 |
| 0.01% | HUMA | HUMACYTE INC | -- | $9,331.77 | 8,407 | BMYTJP4 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $9,072.36 | 1,276 | BKC9SX3 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $8,768.00 | 4,384 | BZ8FPH3 |
| 0.01% | CRBU | CARIBOU BIOSCIENCES INC | -- | $7,636.72 | 4,196 | BNYJR68 |
| 0.01% | QSI | QUANTUM-SI INC | -- | $7,566.60 | 8,780 | BNR5QT9 |
| 0.01% | SGMT | SAGIMET BIOSCIENCES INC-A | -- | $7,530.72 | 1,392 | BP2NYN2 |
| 0.01% | MENS | JYONG BIOTECH LTD | -- | $7,372.08 | 3,413 | BPTK6Z2 |
| 0.01% | TNYA | TENAYA THERAPEUTICS INC | -- | $6,636.91 | 7,474 | BNNXX52 |
| 0.01% | AARD | AARDVARK THERAPEUTICS INC | -- | $5,715.45 | 977 | BTXQTX3 |
| 0.01% | RANI | RANI THERAPEUTICS HOLDINGS-A | -- | $5,694.00 | 4,380 | BNNXX18 |
| 0.01% | BDTX | BLACK DIAMOND THERAPEUTICS I | -- | $5,501.85 | 2,559 | BKTV702 |
| 0.01% | GOSS | GOSSAMER BIO INC | -- | $5,202.77 | 10,391 | BJ0CK86 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $5,070.33 | 2,403 | BP7L561 |
| 0.01% | CDXS | CODEXIS INC | -- | $4,987.65 | 4,055 | B5LL2C2 |
| -- | PYXS | PYXIS ONCOLOGY INC | -- | $3,829.15 | 2,795 | BLBR8D5 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $25.29 | 01 | BTFHQP5 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 32.38% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 26,667,067 | -- | 4,607 | -- |
| 30.16% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 24,837,939 | -- | 4,291 | -- |
| 26.89% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 22,146,342 | -- | 3,826 | -- |
| 18.55% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 15,275,535 | -- | 2,639 | -- |
| 17.46% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 14,378,336 | -- | 2,484 | -- |
| 4.45% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 3,664,045 | -- | 633 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $24,832,022.93 | 24,832,023 | -- |
Index
as of 12/31/2025
- Total Number of Companies262
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$7.32 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2026
- 2026
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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