BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 9/30/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 10/16/2025- NAV $66.28
- NAV Change $-0.42
- Market Price $66.21
- Market Price Change $-0.46
- Trading Volume (M) 25,592
- 30-Day Median Bid Ask Spread 0.25%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 10/16/2025- NAV $66.28
- NAV Change $-0.42
- Market Price $66.21
- Market Price Change $-0.46
- Trading Volume (M) 25,592
- 30-Day Median Bid Ask Spread 0.25%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2026. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 10/16/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 7.67% | -- | B 11/20/25 | -- | $4,981,049.70 | 5,000,000 | -- |
| 4.97% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $3,230,879.27 | 7,907 | 2931034 |
| 4.97% | GILD | GILEAD SCIENCES INC | -- | $3,225,200.95 | 27,367 | 2369174 |
| 4.89% | AMGN | AMGEN INC | -- | $3,178,774.26 | 10,746 | 2023607 |
| 3.60% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,336,556.99 | 4,857 | B00FWN1 |
| 3.38% | REGN | REGENERON PHARMACEUTICALS | -- | $2,196,996.20 | 3,860 | 2730190 |
| 2.50% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $1,621,942.84 | 19,348 | 2989044 |
| 1.98% | INSM | INSMED INC | -- | $1,288,711.43 | 7,897 | 2614487 |
| 1.47% | ARGX | ARGENX SE - ADR | -- | $957,848.32 | 1,144 | BDVLM39 |
| 1.20% | BIIB | BIOGEN INC | -- | $779,300.28 | 5,478 | 2455965 |
| 1.13% | UTHR | UNITED THERAPEUTICS CORP | -- | $731,246.10 | 1,690 | 2430412 |
| 0.98% | INCY | INCYTE CORP | -- | $637,013.76 | 7,296 | 2471950 |
| 0.94% | SMMT | SUMMIT THERAPEUTICS INC | -- | $609,733.41 | 27,753 | BMTVQS7 |
| 0.90% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $586,927.34 | 16,151 | BMVP7Y0 |
| 0.88% | TEM | TEMPUS AI INC | -- | $573,699.06 | 6,303 | BSLSJJ0 |
| 0.85% | ILMN | ILLUMINA INC | -- | $550,715.22 | 5,742 | 2613990 |
| 0.84% | MEDP | MEDPACE HOLDINGS INC | -- | $546,749.29 | 1,049 | BDCBC61 |
| 0.78% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $509,511.60 | 3,705 | 2623911 |
| 0.77% | SNY | SANOFI-ADR | -- | $501,400.48 | 10,024 | 2964557 |
| 0.72% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $470,579.19 | 2,273 | BV9G6B8 |
| 0.68% | VTRS | VIATRIS INC | -- | $439,935.80 | 43,558 | BMWS3X9 |
| 0.67% | ROIV | ROIVANT SCIENCES LTD | -- | $436,527.43 | 25,513 | BMW4NZ9 |
| 0.67% | IONS | IONIS PHARMACEUTICALS INC | -- | $435,131.85 | 5,955 | BDJ0LS6 |
| 0.61% | ONC | BEONE MEDICINES LTD-ADR | -- | $399,115.10 | 1,255 | BYYWPW6 |
| 0.61% | BNTX | BIONTECH SE-ADR | -- | $394,890.64 | 3,758 | BK6H543 |
| 0.61% | MRNA | MODERNA INC | -- | $394,507.04 | 14,536 | BGSXTS3 |
| 0.61% | EXEL | EXELIXIS INC | -- | $394,374.18 | 10,058 | 2576941 |
| 0.61% | BBIO | BRIDGEBIO PHARMA INC | -- | $393,079.29 | 7,143 | BK1KWG8 |
| 0.58% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $379,863.30 | 7,174 | 2437071 |
| 0.57% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $368,294.29 | 833 | BD59BS7 |
| 0.53% | RVMD | REVOLUTION MEDICINES INC | -- | $346,965.12 | 6,984 | BL71K91 |
| 0.48% | GH | GUARDANT HEALTH INC | -- | $314,342.73 | 4,659 | BFXC911 |
| 0.47% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $304,210.50 | 2,266 | B4Q5ZN4 |
| 0.45% | HALO | HALOZYME THERAPEUTICS INC | -- | $292,265.60 | 4,370 | 2975098 |
| 0.42% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $275,837.58 | 2,481 | BF2YWG4 |
| 0.41% | MRUS | MERUS NV | -- | $268,130.88 | 2,826 | BZBY005 |
| 0.41% | CYTK | CYTOKINETICS INC | -- | $263,551.20 | 4,470 | BBBSBJ5 |
| 0.36% | RNA | AVIDITY BIOSCIENCES INC | -- | $234,436.68 | 4,806 | BMWHPY1 |
| 0.36% | AXSM | AXSOME THERAPEUTICS INC | -- | $233,000.00 | 1,864 | BYZR4X4 |
| 0.36% | CRSP | CRISPR THERAPEUTICS AG | -- | $232,525.14 | 3,398 | BDHF4K6 |
| 0.35% | NUVL | NUVALENT INC-A | -- | $225,236.22 | 2,491 | BMVBZD3 |
| 0.33% | PCVX | VAXCYTE INC | -- | $211,411.50 | 4,850 | BKPVGH6 |
| 0.31% | KRYS | KRYSTAL BIOTECH INC | -- | $203,773.06 | 1,082 | BD6JX35 |
| 0.31% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $201,280.05 | 5,165 | BYQBFJ8 |
| 0.31% | PTCT | PTC THERAPEUTICS INC | -- | $198,321.76 | 2,968 | B17VCN9 |
| 0.29% | ALKS | ALKERMES PLC | -- | $189,974.40 | 6,168 | B3P6D26 |
| 0.28% | ACLX | ARCELLX INC | -- | $184,097.20 | 2,072 | BPCJ1Q2 |
| 0.27% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $175,996.52 | 2,324 | BDCBCD8 |
| 0.25% | KYMR | KYMERA THERAPEUTICS INC | -- | $161,488.66 | 2,671 | BMPRZV5 |
| 0.25% | AKRO | AKERO THERAPEUTICS INC | -- | $160,336.08 | 2,988 | BK7Y2V9 |
| 0.24% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $153,465.76 | 4,208 | BP8JSP4 |
| 0.23% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $149,058.13 | 3,523 | BDD19F8 |
| 0.22% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $139,686.34 | 1,877 | BJDX8Y8 |
| 0.20% | LGND | LIGAND PHARMACEUTICALS | -- | $132,323.64 | 732 | 2501578 |
| 0.20% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $129,988.48 | 6,304 | 2713317 |
| 0.20% | ADMA | ADMA BIOLOGICS INC | -- | $129,802.40 | 8,915 | B9NSBM2 |
| 0.20% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $127,890.06 | 786 | BQ721R4 |
| 0.19% | QURE | UNIQURE NV | -- | $122,979.50 | 2,050 | BJFSR88 |
| 0.19% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $122,325.97 | 3,601 | BJ62Z18 |
| 0.19% | XENE | XENON PHARMACEUTICALS INC | -- | $121,491.77 | 2,881 | BRJ3GY4 |
| 0.18% | CGON | CG ONCOLOGY INC | -- | $119,230.65 | 2,849 | BRBCSP4 |
| 0.18% | TARS | TARSUS PHARMACEUTICALS INC | -- | $118,227.69 | 1,577 | BMH5RL1 |
| 0.18% | GRAL | GRAIL INC | -- | $116,394.27 | 1,347 | BSLSSX7 |
| 0.18% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $115,814.58 | 11,734 | BFNF1D6 |
| 0.18% | INDV | INDIVIOR PLC | -- | $115,080.09 | 4,661 | BP0BQQ5 |
| 0.18% | APLS | APELLIS PHARMACEUTICALS INC | -- | $113,939.70 | 4,718 | BYTQ6X1 |
| 0.17% | IMVT | IMMUNOVANT INC | -- | $113,391.33 | 6,513 | BJRFSB7 |
| 0.16% | MLYS | MINERALYS THERAPEUTICS INC | -- | $106,393.72 | 2,476 | BP9N0G0 |
| 0.16% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $105,748.48 | 3,592 | BFZQ0L8 |
| 0.16% | VCYT | VERACYTE INC | -- | $105,281.40 | 2,940 | BFTWZY0 |
| 0.16% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $104,197.44 | 2,094 | B72ZBG4 |
| 0.16% | ALVO | ALVOTECH SA | -- | $102,322.50 | 11,694 | BPNTJ34 |
| 0.16% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $101,804.56 | 3,146 | BMX9K07 |
| 0.16% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $101,531.04 | 15,964 | BM9FJ13 |
| 0.15% | NTLA | INTELLIA THERAPEUTICS INC | -- | $99,889.10 | 4,010 | BYZM6C2 |
| 0.15% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $98,249.03 | 5,689 | BJ5FZ74 |
| 0.15% | BEAM | BEAM THERAPEUTICS INC | -- | $97,486.20 | 3,780 | BK6L288 |
| 0.15% | IRON | DISC MEDICINE INC | -- | $96,593.64 | 1,299 | BMGJZJ8 |
| 0.14% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $93,655.89 | 4,479 | BKX9VD3 |
| 0.14% | FOLD | AMICUS THERAPEUTICS INC | -- | $93,394.76 | 11,516 | B19FQ48 |
| 0.14% | APGE | APOGEE THERAPEUTICS INC | -- | $92,008.20 | 1,723 | BM9HHL5 |
| 0.14% | TVTX | TRAVERE THERAPEUTICS INC | -- | $91,635.81 | 3,331 | BLFGJD5 |
| 0.14% | DNLI | DENALI THERAPEUTICS INC | -- | $91,341.36 | 5,463 | BD2B4V0 |
| 0.14% | IDYA | IDEAYA BIOSCIENCES INC | -- | $90,684.75 | 3,275 | BK0VHF6 |
| 0.14% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $90,139.92 | 2,171 | BCBVTX1 |
| 0.14% | IBRX | IMMUNITYBIO INC | -- | $89,346.95 | 35,315 | BNSP0B8 |
| 0.13% | DYN | DYNE THERAPEUTICS INC | -- | $87,272.30 | 5,315 | BN15WD1 |
| 0.13% | COGT | COGENT BIOSCIENCES INC | -- | $85,382.84 | 5,219 | BLR6XK8 |
| 0.13% | SRPT | SAREPTA THERAPEUTICS INC | -- | $85,214.34 | 3,651 | B8DPDT7 |
| 0.13% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $81,953.10 | 3,585 | BLB0YQ9 |
| 0.13% | ETNB | 89BIO INC | -- | $81,840.57 | 5,541 | BK1K484 |
| 0.12% | OCUL | OCULAR THERAPEUTIX INC | -- | $79,312.20 | 6,501 | BNZB1X8 |
| 0.11% | ANIP | ANI PHARMACEUTICALS INC | -- | $74,571.45 | 811 | BCDWBX6 |
| 0.11% | VERA | VERA THERAPEUTICS INC | -- | $72,766.35 | 2,385 | BL55460 |
| 0.11% | STOK | STOKE THERAPEUTICS INC | -- | $69,980.16 | 2,048 | BJQ05Z6 |
| 0.11% | TWST | TWIST BIOSCIENCE CORP | -- | $69,341.25 | 2,255 | BGKG6G7 |
| 0.10% | VCEL | VERICEL CORP | -- | $65,503.75 | 1,885 | BSBMN89 |
| 0.10% | ABCL | ABCELLERA BIOLOGICS INC | -- | $65,203.60 | 11,165 | BL53SR3 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $63,206.08 | 1,624 | BRXB0C0 |
| 0.09% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $61,348.56 | 2,226 | BQS9486 |
| 0.09% | MNKD | MANNKIND CORP | -- | $61,332.40 | 11,464 | BF081J4 |
| 0.09% | JANX | JANUX THERAPEUTICS INC | -- | $61,064.00 | 2,245 | BMFX8Y7 |
| 0.09% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $60,437.40 | 3,945 | BKY5JZ8 |
| 0.09% | NVCR | NOVOCURE LTD | -- | $58,603.31 | 4,177 | BYSS4X4 |
| 0.09% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $56,802.90 | 4,918 | BFWLC09 |
| 0.09% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $55,766.55 | 2,149 | BKSGZN7 |
| 0.08% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $55,141.62 | 6,033 | BLR7H87 |
| 0.08% | AVDL | AVADEL PHARMACEUTICALS | -- | $54,405.00 | 3,627 | BDGMC59 |
| 0.08% | TXG | 10X GENOMICS INC-CLASS A | -- | $52,912.12 | 4,274 | BKS3RS7 |
| 0.08% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $52,704.96 | 7,843 | 2100362 |
| 0.08% | HROW | HARROW INC | -- | $52,405.44 | 1,382 | BHNDW86 |
| 0.08% | ZYME | ZYMEWORKS INC | -- | $52,106.95 | 2,809 | BPCQZY9 |
| 0.08% | TSHA | TAYSHA GENE THERAPIES INC | -- | $51,775.36 | 10,192 | BNC1BX1 |
| 0.08% | ZLAB | ZAI LAB LTD-ADR | -- | $51,537.08 | 1,787 | BD9GVY0 |
| 0.08% | NVAX | NOVAVAX INC | -- | $51,456.64 | 6,068 | BJDQXG4 |
| 0.08% | GMAB | GENMAB A/S -SP ADR | -- | $51,286.50 | 1,566 | BBC9WC7 |
| 0.08% | SANA | SANA BIOTECHNOLOGY INC | -- | $51,278.13 | 9,666 | BMFJJ97 |
| 0.08% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $50,546.44 | 3,332 | BPCK358 |
| 0.08% | SYRE | SPYRE THERAPEUTICS INC | -- | $50,195.68 | 2,257 | BQBBDY8 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $50,160.88 | 1,496 | BLCD809 |
| 0.07% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $48,430.90 | 3,218 | BN7Q7R7 |
| 0.07% | TRVI | TREVI THERAPEUTICS INC | -- | $48,366.50 | 4,550 | BJH9ZN0 |
| 0.07% | ORIC | ORIC PHARMACEUTICALS INC | -- | $48,252.40 | 3,628 | BKVDFF7 |
| 0.07% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $48,132.75 | 2,213 | BMFD115 |
| 0.07% | WVE | WAVE LIFE SCIENCES LTD | -- | $46,787.15 | 5,945 | BYZG9R0 |
| 0.07% | TRML | TOURMALINE BIO INC | -- | $45,984.00 | 960 | BQ80NC6 |
| 0.07% | ARDX | ARDELYX INC | -- | $45,470.20 | 9,004 | BN89V40 |
| 0.07% | CVAC | CUREVAC NV | -- | $45,172.44 | 8,412 | BN4RD42 |
| 0.07% | GRFS | GRIFOLS SA-ADR | -- | $44,440.50 | 4,558 | B8K7T65 |
| 0.07% | LENZ | LENZ THERAPEUTICS INC | -- | $43,119.70 | 1,066 | BQV0J03 |
| 0.07% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $42,933.80 | 4,381 | BRJZSK0 |
| 0.06% | RLAY | RELAY THERAPEUTICS INC | -- | $41,937.42 | 6,442 | BN2R582 |
| 0.06% | INVA | INNOVIVA INC | -- | $40,606.50 | 2,354 | BDDXF67 |
| 0.06% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $40,333.14 | 1,737 | BNFWZS4 |
| 0.06% | XNCR | XENCOR INC | -- | $39,826.80 | 2,664 | BGCYWN8 |
| 0.06% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $39,088.17 | 1,177 | BX7RSN3 |
| 0.06% | PGEN | PRECIGEN INC | -- | $38,854.17 | 11,133 | BKM5C84 |
| 0.06% | PCRX | PACIRA BIOSCIENCES INC | -- | $38,230.83 | 1,679 | B3X26D8 |
| 0.06% | TNGX | TANGO THERAPEUTICS INC | -- | $38,110.52 | 4,156 | BP2P6L0 |
| 0.06% | PRME | PRIME MEDICINE INC | -- | $37,891.40 | 6,533 | BPBJFM7 |
| 0.06% | SPRY | ARS PHARMACEUTICALS INC | -- | $37,326.12 | 3,692 | BMCR7V2 |
| 0.06% | ORKA | ORUKA THERAPEUTICS INC | -- | $37,184.00 | 1,400 | BKVF0J2 |
| 0.06% | ANAB | ANAPTYSBIO INC | -- | $35,982.40 | 1,046 | BDRW1L7 |
| 0.05% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $35,271.50 | 2,650 | BJLKVS6 |
| 0.05% | PSNL | PERSONALIS INC | -- | $34,057.64 | 3,313 | BJQ0608 |
| 0.05% | RAPP | RAPPORT THERAPEUTICS INC | -- | $33,897.81 | 1,363 | BR3T9B6 |
| 0.05% | MNMD | MIND MEDICINE MINDMED INC | -- | $33,860.13 | 2,843 | BPQYY97 |
| 0.05% | KURA | KURA ONCOLOGY INC | -- | $32,851.59 | 3,243 | BYZD465 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $32,300.62 | 7,162 | BZ0QMB7 |
| 0.05% | FTRE | FORTREA HOLDINGS INC | -- | $32,263.28 | 3,389 | BRXYZ57 |
| 0.05% | MESO | MESOBLAST LTD- SPON ADR | -- | $31,910.76 | 1,764 | BQS7491 |
| 0.05% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $31,685.20 | 4,520 | BYVQJ96 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $30,284.80 | 13,520 | BF0DMK7 |
| 0.05% | VIR | VIR BIOTECHNOLOGY INC | -- | $30,102.00 | 5,190 | BK4PZ38 |
| 0.05% | EYPT | EYEPOINT PHARMACEUTICALS INC | -- | $29,741.25 | 2,575 | BMGS7L1 |
| 0.05% | AVBP | ARRIVENT BIOPHARMA INC | -- | $29,731.88 | 1,515 | BMGTLY5 |
| 0.05% | TYRA | TYRA BIOSCIENCES INC | -- | $29,546.44 | 1,991 | BMVNDH9 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $29,351.77 | 761 | BL95N25 |
| 0.05% | GERN | GERON CORP | -- | $29,318.28 | 23,836 | 2370381 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $29,271.97 | 1,729 | BZ7PJQ1 |
| 0.04% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $28,913.09 | 3,209 | BYTYP72 |
| 0.04% | NRIX | NURIX THERAPEUTICS INC | -- | $28,645.68 | 2,856 | BMVLGP2 |
| 0.04% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $28,587.69 | 3,827 | BLB0YH0 |
| 0.04% | TERN | TERNS PHARMACEUTICALS INC | -- | $28,154.70 | 3,270 | BMDJ0C9 |
| 0.04% | CRMD | CORMEDIX INC | -- | $28,113.12 | 2,789 | BJ0LT31 |
| 0.04% | ABSI | ABSCI CORP | -- | $27,208.69 | 5,587 | BN94K69 |
| 0.04% | ERAS | ERASCA INC | -- | $26,812.94 | 10,598 | BNLYBF3 |
| 0.04% | ARVN | ARVINAS INC | -- | $26,552.24 | 2,743 | BDZ30Q0 |
| 0.04% | TBPH | THERAVANCE BIOPHARMA INC | -- | $26,409.24 | 1,881 | BMNDK09 |
| 0.04% | ATXS | ASTRIA THERAPEUTICS INC | -- | $25,497.81 | 2,109 | BMYRFN8 |
| 0.04% | OMER | OMEROS CORP | -- | $24,987.86 | 2,542 | B4NB858 |
| 0.04% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $24,614.40 | 2,564 | BMZ4LN0 |
| 0.04% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $24,438.78 | 3,006 | BFYQFJ2 |
| 0.04% | CSTL | CASTLE BIOSCIENCES INC | -- | $24,422.52 | 1,084 | BKLCWZ3 |
| 0.04% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $23,875.24 | 2,098 | BLFBZ32 |
| 0.04% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $23,795.48 | 2,308 | BP7KZP7 |
| 0.04% | RGNX | REGENXBIO INC | -- | $23,285.58 | 1,887 | BZ0G875 |
| 0.04% | SVRA | SAVARA INC | -- | $23,116.06 | 6,457 | BYXGN81 |
| 0.03% | SIGA | SIGA TECHNOLOGIES INC | -- | $22,344.60 | 2,676 | 2107437 |
| 0.03% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $22,055.95 | 1,015 | BKC9SX3 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $21,960.66 | 3,426 | BMC3HS7 |
| 0.03% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $21,297.60 | 2,784 | BYP80F1 |
| 0.03% | KROS | KEROS THERAPEUTICS INC | -- | $20,857.32 | 1,518 | BM7V485 |
| 0.03% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $20,766.24 | 1,881 | BD06CS0 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $20,290.99 | 2,011 | B91XRN2 |
| 0.03% | ESPR | ESPERION THERAPEUTICS INC | -- | $19,962.45 | 7,533 | BBNBTD2 |
| 0.03% | LXRX | LEXICON PHARMACEUTICALS INC | -- | $19,956.72 | 13,576 | BWFZX59 |
| 0.03% | INBX | INHIBRX BIOSCIENCES INC | -- | $19,797.90 | 541 | BNSP8K3 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $19,750.72 | 11,222 | B4N8MH9 |
| 0.03% | CGEM | CULLINAN THERAPEUTICS INC | -- | $19,289.18 | 2,207 | BM90J52 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $18,866.94 | 5,406 | BMCWKZ2 |
| 0.03% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $18,833.70 | 670 | BQD3J33 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $18,238.15 | 535 | B292NQ7 |
| 0.03% | NGNE | NEUROGENE INC | -- | $18,116.67 | 533 | BS2F741 |
| 0.03% | SLDB | SOLID BIOSCIENCES INC | -- | $17,919.44 | 2,909 | BQHN6C7 |
| 0.03% | HCM | HUTCHMED CHINA-ADR | -- | $17,848.60 | 1,159 | BYXV9H7 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $17,689.09 | 2,017 | BQ6C357 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $17,607.05 | 1,745 | BKLXFX5 |
| 0.03% | ALMS | ALUMIS INC | -- | $16,683.59 | 3,619 | BPLQG36 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $16,124.00 | 4,031 | BDFKQ07 |
| 0.02% | EOLS | EVOLUS INC | -- | $15,220.80 | 2,416 | BDRJH21 |
| 0.02% | AMRN | AMARIN CORP PLC -ADR | -- | $15,112.71 | 753 | BN72KB0 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $14,938.55 | 1,727 | BKDQKM6 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $14,366.99 | 2,321 | BP81R42 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $13,623.48 | 3,198 | BMXNGZ6 |
| 0.02% | REPL | REPLIMUNE GROUP INC | -- | $13,617.72 | 2,916 | BDDVW37 |
| 0.02% | EDIT | EDITAS MEDICINE INC | -- | $13,301.64 | 3,359 | BZ8FPH3 |
| 0.02% | DSGN | DESIGN THERAPEUTICS INC | -- | $13,129.76 | 2,128 | BMFK3H6 |
| 0.02% | ANNX | ANNEXON INC | -- | $13,016.02 | 4,106 | BMVV9R5 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $12,825.33 | 3,297 | BFY7DC4 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $12,588.24 | 7,493 | BFMLGR4 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $12,337.35 | 699 | BPBPCG8 |
| 0.02% | LYEL | LYELL IMMUNOPHARMA INC | -- | $12,206.00 | 718 | BTNMG41 |
| 0.02% | ALEC | ALECTOR INC | -- | $12,178.04 | 3,782 | BJ4LDC4 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $11,630.89 | 2,207 | B12W3P6 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $11,558.86 | 1,754 | BL5B6Z1 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $11,328.16 | 1,616 | BSMLR16 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $11,102.96 | 3,751 | BZC0D70 |
| 0.02% | VYGR | VOYAGER THERAPEUTICS INC | -- | $11,043.76 | 2,072 | BY7RB53 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $10,770.78 | 6,051 | BN4JN37 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $10,527.03 | 8,289 | BFZNYB7 |
| 0.02% | TKNO | ALPHA TEKNOVA INC | -- | $10,514.74 | 1,999 | BP7L561 |
| 0.02% | HUMA | HUMACYTE INC | -- | $10,058.90 | 5,917 | BMYTJP4 |
| 0.01% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $9,406.95 | 6,069 | B3MZ6K5 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $9,250.80 | 2,965 | BLN9Z50 |
| 0.01% | RNAC | CARTESIAN THERAPEUTICS INC | -- | $9,146.82 | 971 | BQB9HM8 |
| 0.01% | FHTX | FOGHORN THERAPEUTICS INC | -- | $9,102.72 | 2,112 | BMF7DT9 |
| 0.01% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $9,081.24 | 798 | B9L5200 |
| 0.01% | CDXS | CODEXIS INC | -- | $8,902.08 | 3,372 | B5LL2C2 |
| 0.01% | TRDA | ENTRADA THERAPEUTICS INC | -- | $8,781.78 | 1,421 | BP81RK8 |
| 0.01% | OABI | OMNIAB INC | -- | $7,792.80 | 4,584 | BN13S71 |
| 0.01% | PYXS | PYXIS ONCOLOGY INC | -- | $7,761.95 | 2,317 | BLBR8D5 |
| 0.01% | MXCT | MAXCYTE INC | -- | $7,049.91 | 3,983 | BKMQF66 |
| 0.01% | APLT | APPLIED THERAPEUTICS INC | -- | $6,725.00 | 5,380 | BJL38Z1 |
| 0.01% | FATE | FATE THERAPEUTICS INC | -- | $6,635.86 | 4,309 | BCZS820 |
| 0.01% | NKTX | NKARTA INC | -- | $6,605.97 | 2,653 | BK80YJ8 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $6,594.32 | 2,659 | BKX9NQ0 |
| 0.01% | PEPG | PEPGEN INC | -- | $5,880.00 | 1,225 | BMTX3D7 |
| 0.01% | TVGN | TEVOGEN BIO HOLDINGS INC | -- | $5,304.51 | 7,349 | BPG5P75 |
| 0.01% | CLYM | CLIMB BIO INC | -- | $4,935.45 | 2,531 | BMW5LX6 |
| 0.01% | TCRX | TSCAN THERAPEUTICS INC | -- | $4,860.80 | 1,960 | BNLYBJ7 |
| 0.01% | MGNX | MACROGENICS INC | -- | $3,991.78 | 2,362 | BFDV8K0 |
| 0.01% | PLRX | PLIANT THERAPEUTICS INC | -- | $3,785.10 | 2,294 | BMDWW66 |
| 0.01% | BMEA | BIOMEA FUSION INC | -- | $3,534.57 | 2,223 | BNKF6N0 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $2,789.18 | 3,167 | BF12XC2 |
| -- | ARTV | ARTIVA BIOTHERAPEUTICS INC | -- | $2,526.24 | 912 | BMF1LJ7 |
| -- | ACRV | ACRIVON THERAPEUTICS INC | -- | $2,197.25 | 1,175 | BP2TPK4 |
| -- | MRSN | MERSANA THERAPEUTICS INC | -- | $1,970.05 | 187 | BVPKH99 |
| -- | QTTB | Q32 BIO INC | -- | $1,641.60 | 456 | BS2FKQ4 |
| -- | OKUR | ONKURE THERAPEUTICS INC-A | -- | $1,379.52 | 479 | BT7KGT6 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 29.18% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 18,956,753 | -- | 3,675 | -- |
| 26.77% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 17,388,629 | -- | 3,371 | -- |
| 23.56% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 15,304,676 | -- | 2,967 | -- |
| 20.26% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 13,158,823 | -- | 2,551 | -- |
| 19.73% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 12,813,217 | -- | 2,484 | -- |
| 15.24% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 9,898,778 | -- | 1,919 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $17,766,544.28 | 17,766,544 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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